ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.36850403
2	signal peptide processing (GO:0006465)	6.32261089
3	negative regulation of response to food (GO:0032096)	6.22231720
4	negative regulation of appetite (GO:0032099)	6.22231720
5	histone H2A acetylation (GO:0043968)	5.91833612
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.52076270
7	ATP synthesis coupled proton transport (GO:0015986)	5.52076270
8	ribosomal large subunit biogenesis (GO:0042273)	5.46026996
9	urate metabolic process (GO:0046415)	5.43830045
10	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.19618079
11	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.19618079
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.12072004
13	respiratory electron transport chain (GO:0022904)	4.89609957
14	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.88862449
15	phosphate ion transport (GO:0006817)	4.87312562
16	electron transport chain (GO:0022900)	4.76697733
17	histone H4-K12 acetylation (GO:0043983)	4.73356333
18	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	4.65778365
19	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	4.65778365
20	regulation of transmission of nerve impulse (GO:0051969)	4.60540029
21	positive regulation of action potential (GO:0045760)	4.55456843
22	translational termination (GO:0006415)	4.53265789
23	viral transcription (GO:0019083)	4.44406924
24	adult feeding behavior (GO:0008343)	4.18578061
25	behavioral response to ethanol (GO:0048149)	4.06524474
26	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.05808148
27	cotranslational protein targeting to membrane (GO:0006613)	4.02250175
28	behavioral response to nicotine (GO:0035095)	4.02132087
29	positive regulation of catecholamine secretion (GO:0033605)	3.96087522
30	regulation of appetite (GO:0032098)	3.93584773
31	protein targeting to ER (GO:0045047)	3.93351376
32	negative regulation of heart rate (GO:0010459)	3.89945522
33	substrate-independent telencephalic tangential migration (GO:0021826)	3.88648385
34	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.88648385
35	ribosomal small subunit assembly (GO:0000028)	3.82313341
36	proteasome assembly (GO:0043248)	3.80741910
37	protein localization to endoplasmic reticulum (GO:0070972)	3.76975689
38	regulation of response to food (GO:0032095)	3.76585758
39	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.73345483
40	regulation of uterine smooth muscle contraction (GO:0070472)	3.66468657
41	phosphate ion transmembrane transport (GO:0035435)	3.65375335
42	auditory behavior (GO:0031223)	3.61172135
43	positive regulation of blood pressure (GO:0045777)	3.61086401
44	peptidyl-tyrosine autophosphorylation (GO:0038083)	3.58285729
45	peristalsis (GO:0030432)	3.50349080
46	translational elongation (GO:0006414)	3.44408309
47	regulation of neurotransmitter uptake (GO:0051580)	3.43996523
48	thalamus development (GO:0021794)	3.42459283
49	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.39819217
50	termination of RNA polymerase III transcription (GO:0006386)	3.37539704
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.37539704
52	behavioral response to cocaine (GO:0048148)	3.37381202
53	viral life cycle (GO:0019058)	3.37102962
54	protein complex biogenesis (GO:0070271)	3.34732015
55	cellular protein complex disassembly (GO:0043624)	3.34260570
56	heart process (GO:0003015)	3.30322181
57	heart contraction (GO:0060047)	3.30322181
58	rRNA modification (GO:0000154)	3.28041446
59	protein neddylation (GO:0045116)	3.23798363
60	regulation of cell communication by electrical coupling (GO:0010649)	3.22241956
61	transmission of nerve impulse (GO:0019226)	3.21274806
62	negative regulation of catecholamine secretion (GO:0033604)	3.20543568
63	regulation of action potential (GO:0098900)	3.19259275
64	fusion of sperm to egg plasma membrane (GO:0007342)	3.15640274
65	mitochondrial respiratory chain complex assembly (GO:0033108)	3.07904052
66	piRNA metabolic process (GO:0034587)	3.05324171
67	spliceosomal snRNP assembly (GO:0000387)	3.00725241
68	striatum development (GO:0021756)	2.94734821
69	histone mRNA metabolic process (GO:0008334)	2.94506653
70	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.94023635
71	rRNA methylation (GO:0031167)	2.93778712
72	negative regulation of macrophage differentiation (GO:0045650)	2.92218213
73	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.88935986
74	hydrogen ion transmembrane transport (GO:1902600)	2.88106522
75	synaptic transmission, dopaminergic (GO:0001963)	2.86640964
76	dopamine transport (GO:0015872)	2.80595720
77	regulation of hexokinase activity (GO:1903299)	2.80187673
78	regulation of glucokinase activity (GO:0033131)	2.80187673
79	ATP biosynthetic process (GO:0006754)	2.79638539
80	translational initiation (GO:0006413)	2.78479119
81	protein targeting to membrane (GO:0006612)	2.78460382
82	positive regulation of neurological system process (GO:0031646)	2.73860607
83	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.73331761
84	sequestering of actin monomers (GO:0042989)	2.73267211
85	phasic smooth muscle contraction (GO:0014821)	2.71570049
86	detection of light stimulus involved in sensory perception (GO:0050962)	2.71327072
87	detection of light stimulus involved in visual perception (GO:0050908)	2.71327072
88	negative regulation of bone resorption (GO:0045779)	2.71295966
89	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.70337463
90	proton transport (GO:0015992)	2.69526811
91	translation (GO:0006412)	2.68516574
92	negative regulation of norepinephrine secretion (GO:0010700)	2.67356267
93	protein localization to cilium (GO:0061512)	2.67269280
94	hydrogen transport (GO:0006818)	2.66031063
95	polyamine biosynthetic process (GO:0006596)	2.65994595
96	protein complex disassembly (GO:0043241)	2.65301266
97	neuron remodeling (GO:0016322)	2.64487194
98	cullin deneddylation (GO:0010388)	2.64094429
99	regulation of catecholamine metabolic process (GO:0042069)	2.63745928
100	regulation of dopamine metabolic process (GO:0042053)	2.63745928

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	5.79482417
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.83032491
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.99532275
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.74063752
5	VDR_22108803_ChIP-Seq_LS180_Human	2.42469621
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40928918
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.40328067
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34942417
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34075437
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.32989508
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20715034
12	FUS_26573619_Chip-Seq_HEK293_Human	2.11004348
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.07799743
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04958069
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04062676
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00297717
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.98183257
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.93539089
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.92266032
20	P300_19829295_ChIP-Seq_ESCs_Human	1.88124418
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86887527
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.84673821
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84405677
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.81999578
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.80558869
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79607675
27	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.78480382
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70640988
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68447252
30	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.54710270
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50999101
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49005583
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45975773
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44471855
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42329663
36	EWS_26573619_Chip-Seq_HEK293_Human	1.40944893
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38669179
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.36841716
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33046889
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33007008
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31940685
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30903517
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29099662
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26282045
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.25848715
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.24609316
47	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.23527968
48	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.22685003
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22261218
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22261218
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20834423
52	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17050027
53	AR_25329375_ChIP-Seq_VCAP_Human	1.16723741
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15695284
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14677014
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14567539
57	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13182738
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13129661
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13104284
60	VDR_23849224_ChIP-Seq_CD4+_Human	1.12677574
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.11918309
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11030781
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11030781
64	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.10100204
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10041155
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09286979
67	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.08708993
68	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08599989
69	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.08406573
70	AR_20517297_ChIP-Seq_VCAP_Human	1.07370401
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06986671
72	NCOR_22424771_ChIP-Seq_293T_Human	1.05741582
73	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.05495912
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.05245045
75	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05174089
76	ERG_20517297_ChIP-Seq_VCAP_Human	1.03693636
77	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.03653479
78	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.03567618
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01278209
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00806829
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00742429
82	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.99908770
83	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98942033
84	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.98840664
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98770837
86	P300_18555785_Chip-Seq_ESCs_Mouse	0.98535895
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.98448806
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97551668
89	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.97124881
90	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.96295692
91	CDX2_22108803_ChIP-Seq_LS180_Human	0.96237443
92	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95009243
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.94235880
94	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.93765906
95	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.93609352
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93368176
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92630205
98	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.91728606
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.91566859
100	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.90974875

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.42736736
2	MP0002822_catalepsy	4.37874336
3	MP0005645_abnormal_hypothalamus_physiol	3.50254822
4	MP0001529_abnormal_vocalization	3.48545559
5	MP0006292_abnormal_olfactory_placode	3.33081324
6	MP0003878_abnormal_ear_physiology	2.93524564
7	MP0005377_hearing/vestibular/ear_phenot	2.93524564
8	MP0004147_increased_porphyrin_level	2.82836688
9	MP0002138_abnormal_hepatobiliary_system	2.61326984
10	MP0005085_abnormal_gallbladder_physiolo	2.38319843
11	MP0004510_myositis	2.07392914
12	MP0008877_abnormal_DNA_methylation	2.06358478
13	MP0001188_hyperpigmentation	2.06322983
14	MP0010386_abnormal_urinary_bladder	2.03303882
15	MP0005397_hematopoietic_system_phenotyp	1.81400741
16	MP0001545_abnormal_hematopoietic_system	1.81400741
17	MP0001486_abnormal_startle_reflex	1.79139262
18	MP0003136_yellow_coat_color	1.73037857
19	MP0001485_abnormal_pinna_reflex	1.71925921
20	MP0004142_abnormal_muscle_tone	1.69336418
21	MP0001905_abnormal_dopamine_level	1.65869881
22	MP0002736_abnormal_nociception_after	1.65422899
23	MP0006072_abnormal_retinal_apoptosis	1.63846090
24	MP0006276_abnormal_autonomic_nervous	1.60156104
25	MP0003252_abnormal_bile_duct	1.59579032
26	MP0002909_abnormal_adrenal_gland	1.54364523
27	MP0000372_irregular_coat_pigmentation	1.53897121
28	MP0003646_muscle_fatigue	1.51726623
29	MP0008789_abnormal_olfactory_epithelium	1.49846405
30	MP0003186_abnormal_redox_activity	1.49256421
31	MP0005075_abnormal_melanosome_morpholog	1.49106953
32	MP0001756_abnormal_urination	1.48404403
33	MP0004019_abnormal_vitamin_homeostasis	1.47602644
34	MP0004133_heterotaxia	1.46326899
35	MP0003137_abnormal_impulse_conducting	1.39943424
36	MP0003941_abnormal_skin_development	1.39711128
37	MP0009745_abnormal_behavioral_response	1.39165476
38	MP0002837_dystrophic_cardiac_calcinosis	1.38610083
39	MP0002332_abnormal_exercise_endurance	1.38409892
40	MP0003890_abnormal_embryonic-extraembry	1.37346213
41	MP0001968_abnormal_touch/_nociception	1.37148244
42	MP0005646_abnormal_pituitary_gland	1.35462970
43	MP0005409_darkened_coat_color	1.34236192
44	MP0009697_abnormal_copulation	1.32339326
45	MP0005360_urolithiasis	1.28712341
46	MP0000631_abnormal_neuroendocrine_gland	1.26667804
47	MP0002277_abnormal_respiratory_mucosa	1.25901718
48	MP0005551_abnormal_eye_electrophysiolog	1.23638350
49	MP0002735_abnormal_chemical_nociception	1.21870933
50	MP0002638_abnormal_pupillary_reflex	1.19765871
51	MP0009046_muscle_twitch	1.19685239
52	MP0008004_abnormal_stomach_pH	1.19144619
53	MP0003880_abnormal_central_pattern	1.17476786
54	MP0008872_abnormal_physiological_respon	1.16909048
55	MP0002272_abnormal_nervous_system	1.16440636
56	MP0005394_taste/olfaction_phenotype	1.13092449
57	MP0005499_abnormal_olfactory_system	1.13092449
58	MP0001664_abnormal_digestion	1.09584033
59	MP0002184_abnormal_innervation	1.09200945
60	MP0003283_abnormal_digestive_organ	1.07870171
61	MP0005365_abnormal_bile_salt	1.07557349
62	MP0003195_calcinosis	1.05435508
63	MP0002064_seizures	1.04958650
64	MP0005464_abnormal_platelet_physiology	1.04424012
65	MP0005636_abnormal_mineral_homeostasis	1.04123935
66	MP0008875_abnormal_xenobiotic_pharmacok	1.03749162
67	MP0002160_abnormal_reproductive_system	1.02662367
68	MP0004145_abnormal_muscle_electrophysio	1.02316949
69	MP0000538_abnormal_urinary_bladder	1.00230385
70	MP0004215_abnormal_myocardial_fiber	0.98917486
71	MP0005332_abnormal_amino_acid	0.94113706
72	MP0001970_abnormal_pain_threshold	0.93748475
73	MP0003718_maternal_effect	0.93238848
74	MP0009765_abnormal_xenobiotic_induced	0.92148805
75	MP0001873_stomach_inflammation	0.91115108
76	MP0005389_reproductive_system_phenotype	0.90779820
77	MP0002733_abnormal_thermal_nociception	0.90403070
78	MP0003011_delayed_dark_adaptation	0.88346470
79	MP0000015_abnormal_ear_pigmentation	0.87803469
80	MP0005083_abnormal_biliary_tract	0.87689941
81	MP0000465_gastrointestinal_hemorrhage	0.86952395
82	MP0001963_abnormal_hearing_physiology	0.85733751
83	MP0004085_abnormal_heartbeat	0.81748414
84	MP0001984_abnormal_olfaction	0.81561044
85	MP0002734_abnormal_mechanical_nocicepti	0.80543115
86	MP0005448_abnormal_energy_balance	0.80214992
87	MP0005670_abnormal_white_adipose	0.80079096
88	MP0002572_abnormal_emotion/affect_behav	0.79337222
89	MP0002229_neurodegeneration	0.78079141
90	MP0002067_abnormal_sensory_capabilities	0.75382123
91	MP0003724_increased_susceptibility_to	0.74395015
92	MP0004924_abnormal_behavior	0.74143057
93	MP0005386_behavior/neurological_phenoty	0.74143057
94	MP0001293_anophthalmia	0.71818908
95	MP0005174_abnormal_tail_pigmentation	0.71233657
96	MP0005253_abnormal_eye_physiology	0.70923110
97	MP0002751_abnormal_autonomic_nervous	0.70024648
98	MP0005319_abnormal_enzyme/_coenzyme	0.69734240
99	MP0000230_abnormal_systemic_arterial	0.69202833
100	MP0003635_abnormal_synaptic_transmissio	0.68984303

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Generalized aminoaciduria (HP:0002909)	6.49072820
2	Acute necrotizing encephalopathy (HP:0006965)	4.54827395
3	Severe visual impairment (HP:0001141)	4.54732037
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.28249920
5	Hepatic necrosis (HP:0002605)	4.17890527
6	Hepatocellular necrosis (HP:0001404)	4.16027884
7	3-Methylglutaconic aciduria (HP:0003535)	4.04265501
8	Proximal tubulopathy (HP:0000114)	4.03329379
9	Progressive macrocephaly (HP:0004481)	3.89690531
10	Reticulocytopenia (HP:0001896)	3.79265247
11	Mitochondrial inheritance (HP:0001427)	3.73421664
12	Acute encephalopathy (HP:0006846)	3.68706400
13	Pendular nystagmus (HP:0012043)	3.67475401
14	Optic nerve hypoplasia (HP:0000609)	3.61871584
15	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.38093025
16	Abnormality of placental membranes (HP:0011409)	3.37292242
17	Amniotic constriction ring (HP:0009775)	3.37292242
18	Increased CSF lactate (HP:0002490)	3.23680121
19	Congenital, generalized hypertrichosis (HP:0004540)	3.22655597
20	Septo-optic dysplasia (HP:0100842)	3.21466591
21	Pancreatic cysts (HP:0001737)	3.17450596
22	Abnormal number of erythroid precursors (HP:0012131)	3.12647022
23	Congenital stationary night blindness (HP:0007642)	3.11780172
24	Stenosis of the external auditory canal (HP:0000402)	3.07646218
25	Abnormality of cells of the erythroid lineage (HP:0012130)	3.02385579
26	Oral leukoplakia (HP:0002745)	3.00703616
27	Myokymia (HP:0002411)	2.98106375
28	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.90129395
29	Macrocytic anemia (HP:0001972)	2.85450568
30	Glycosuria (HP:0003076)	2.84042271
31	Abnormality of urine glucose concentration (HP:0011016)	2.84042271
32	Cerebral edema (HP:0002181)	2.82394882
33	Abnormality of macular pigmentation (HP:0008002)	2.76602807
34	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.71627545
35	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.71627545
36	Abnormality of methionine metabolism (HP:0010901)	2.53519630
37	Aplastic anemia (HP:0001915)	2.51382455
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.51218346
39	Optic disc pallor (HP:0000543)	2.49957805
40	True hermaphroditism (HP:0010459)	2.49892617
41	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.49549569
42	J-shaped sella turcica (HP:0002680)	2.45392425
43	Median cleft lip (HP:0000161)	2.43041750
44	Pancreatic fibrosis (HP:0100732)	2.42200231
45	Parakeratosis (HP:0001036)	2.41291069
46	Molar tooth sign on MRI (HP:0002419)	2.39188642
47	Abnormality of midbrain morphology (HP:0002418)	2.39188642
48	Hypothermia (HP:0002045)	2.37441127
49	Absent septum pellucidum (HP:0001331)	2.37212592
50	Nephronophthisis (HP:0000090)	2.36826113
51	Rickets (HP:0002748)	2.35634769
52	Respiratory failure (HP:0002878)	2.32805207
53	Abnormality of the renal collecting system (HP:0004742)	2.30732751
54	Pallor (HP:0000980)	2.28334262
55	Abolished electroretinogram (ERG) (HP:0000550)	2.24284412
56	Maternal diabetes (HP:0009800)	2.22287083
57	Intestinal atresia (HP:0011100)	2.19195467
58	Attenuation of retinal blood vessels (HP:0007843)	2.08531246
59	Sclerocornea (HP:0000647)	2.08131787
60	Renal Fanconi syndrome (HP:0001994)	2.07371723
61	Abnormality of serum amino acid levels (HP:0003112)	2.07284096
62	Abnormality of the renal medulla (HP:0100957)	2.03859128
63	Increased intramyocellular lipid droplets (HP:0012240)	2.02678631
64	Methylmalonic aciduria (HP:0012120)	2.02371497
65	Renal cortical cysts (HP:0000803)	1.99853785
66	Enlarged epiphyses (HP:0010580)	1.97813151
67	Popliteal pterygium (HP:0009756)	1.94659918
68	Respiratory difficulties (HP:0002880)	1.92979691
69	Homocystinuria (HP:0002156)	1.92583054
70	Abnormality of homocysteine metabolism (HP:0010919)	1.92583054
71	Hyperventilation (HP:0002883)	1.90948164
72	Decreased central vision (HP:0007663)	1.90793154
73	Abnormality of the renal cortex (HP:0011035)	1.90024768
74	Conjugated hyperbilirubinemia (HP:0002908)	1.88429370
75	Hyperphosphaturia (HP:0003109)	1.86280505
76	Pancreatic islet-cell hyperplasia (HP:0004510)	1.85197728
77	Increased hepatocellular lipid droplets (HP:0006565)	1.83131264
78	Split foot (HP:0001839)	1.82502645
79	Exertional dyspnea (HP:0002875)	1.81429599
80	Constricted visual fields (HP:0001133)	1.80531544
81	Abnormality of the labia minora (HP:0012880)	1.80089971
82	Progressive cerebellar ataxia (HP:0002073)	1.78197324
83	Cystic liver disease (HP:0006706)	1.75535777
84	Leukodystrophy (HP:0002415)	1.74267151
85	Retinal dysplasia (HP:0007973)	1.73651861
86	Recurrent corneal erosions (HP:0000495)	1.71463294
87	Lethargy (HP:0001254)	1.70096999
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.69946001
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68458253
90	Abnormality of the septum pellucidum (HP:0007375)	1.67438410
91	Hypophosphatemic rickets (HP:0004912)	1.67380469
92	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.66847843
93	Brushfield spots (HP:0001088)	1.66110912
94	Gliosis (HP:0002171)	1.65700485
95	Duplicated collecting system (HP:0000081)	1.65294015
96	Lactic acidosis (HP:0003128)	1.65031777
97	Triphalangeal thumb (HP:0001199)	1.63890079
98	Hypoglycemic coma (HP:0001325)	1.63387131
99	Medial flaring of the eyebrow (HP:0010747)	1.62444354
100	Abnormality of renal resorption (HP:0011038)	1.62395107

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	4.51289685
2	CASK	4.13465240
3	MAP3K12	4.00110589
4	CDK19	3.68281333
5	FRK	2.91060154
6	MAP3K9	2.45997744
7	MAP4K2	2.43274004
8	MYLK	2.33937775
9	MAP3K10	2.30440932
10	PIM2	2.04157987
11	BMPR1B	2.02094320
12	TLK1	2.01684511
13	PASK	1.96853442
14	ADRBK2	1.94765943
15	VRK2	1.90548524
16	TAOK3	1.75406127
17	WNK3	1.60201094
18	PDK2	1.49013043
19	DYRK2	1.45498320
20	TXK	1.44825693
21	TGFBR1	1.29524292
22	MOS	1.27706122
23	TEC	1.27473147
24	PAK4	1.25831154
25	MATK	1.23105187
26	DAPK3	1.22120116
27	NME1	1.22048875
28	VRK1	1.20800763
29	INSRR	1.17795195
30	PRKG2	1.16210228
31	GRK5	1.12610966
32	BRAF	1.10599333
33	NEK1	1.09902990
34	MST4	1.06532048
35	DAPK1	1.06492755
36	TIE1	1.04887040
37	NTRK3	1.03194201
38	TRIM28	1.01862200
39	ILK	0.99957727
40	ZAK	0.98877602
41	AURKA	0.98191517
42	GRK7	0.97535265
43	EIF2AK1	0.94469729
44	PBK	0.91651535
45	DAPK2	0.87592630
46	GRK1	0.85329052
47	RPS6KA5	0.82852096
48	NUAK1	0.81953021
49	FLT3	0.78089644
50	RAF1	0.74844836
51	FGFR2	0.74144830
52	FES	0.73423604
53	PRKCG	0.72550448
54	DDR2	0.70389366
55	PLK4	0.68697123
56	PTK2B	0.68051300
57	TNIK	0.63786490
58	EGFR	0.63338611
59	PLK3	0.60277238
60	OBSCN	0.58248722
61	PRKCE	0.56776480
62	ADRBK1	0.56488106
63	MAP3K4	0.54700444
64	KDR	0.54629543
65	NTRK2	0.53220545
66	CDC7	0.51618076
67	LMTK2	0.51150949
68	EIF2AK3	0.50096903
69	PLK1	0.49542539
70	PIK3CG	0.49045928
71	PRKACA	0.48921737
72	CSNK1G3	0.48409686
73	BCR	0.47320896
74	ALK	0.47279421
75	BMPR2	0.46665083
76	ACVR1B	0.46439614
77	BUB1	0.44085910
78	CSNK1G1	0.43673399
79	RPS6KA6	0.43467742
80	OXSR1	0.43407771
81	EPHA4	0.42818998
82	MAP2K7	0.40839755
83	CDK8	0.39828354
84	CSNK1G2	0.39343516
85	BMX	0.39091711
86	CSNK2A1	0.39014536
87	CSNK2A2	0.38000881
88	CSNK1A1	0.36074760
89	PRKCD	0.35210493
90	FGR	0.35184468
91	CSNK1E	0.35139265
92	AURKB	0.34475242
93	LYN	0.34220687
94	ERBB2	0.33172187
95	TYRO3	0.31282859
96	CAMK2A	0.30940059
97	PRKCA	0.30372161
98	IKBKB	0.29866292
99	SRPK1	0.29446423
100	PRKACG	0.27861171

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.41982531
2	Ribosome_Homo sapiens_hsa03010	4.22491790
3	Parkinsons disease_Homo sapiens_hsa05012	3.94987604
4	Proteasome_Homo sapiens_hsa03050	3.27686286
5	Protein export_Homo sapiens_hsa03060	2.94360542
6	Alzheimers disease_Homo sapiens_hsa05010	2.81097819
7	Huntingtons disease_Homo sapiens_hsa05016	2.62001439
8	Asthma_Homo sapiens_hsa05310	2.44998045
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.42603210
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.36705372
11	RNA polymerase_Homo sapiens_hsa03020	2.18476947
12	Renin-angiotensin system_Homo sapiens_hsa04614	1.94757788
13	Nicotine addiction_Homo sapiens_hsa05033	1.93825581
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.90968454
15	Phototransduction_Homo sapiens_hsa04744	1.74679195
16	Taste transduction_Homo sapiens_hsa04742	1.63789751
17	Allograft rejection_Homo sapiens_hsa05330	1.63430969
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.63048371
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.57836083
20	Homologous recombination_Homo sapiens_hsa03440	1.43911478
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.43360062
22	Retinol metabolism_Homo sapiens_hsa00830	1.43093746
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.35624890
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34648793
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.33212149
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.30579869
27	Caffeine metabolism_Homo sapiens_hsa00232	1.25110910
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.23844717
29	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.22929965
30	Butanoate metabolism_Homo sapiens_hsa00650	1.20602484
31	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.18420078
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14936327
33	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.14347304
34	Arginine biosynthesis_Homo sapiens_hsa00220	1.07289669
35	Fatty acid degradation_Homo sapiens_hsa00071	1.05416711
36	Mismatch repair_Homo sapiens_hsa03430	1.04122187
37	Morphine addiction_Homo sapiens_hsa05032	1.03913749
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.03730058
39	Sulfur relay system_Homo sapiens_hsa04122	1.02115519
40	Circadian entrainment_Homo sapiens_hsa04713	1.00402334
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98764938
42	One carbon pool by folate_Homo sapiens_hsa00670	0.98438663
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98136734
44	Olfactory transduction_Homo sapiens_hsa04740	0.97321726
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.91027777
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84659791
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.83862380
48	Regulation of autophagy_Homo sapiens_hsa04140	0.83372140
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83102013
50	African trypanosomiasis_Homo sapiens_hsa05143	0.80226765
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79930708
52	Serotonergic synapse_Homo sapiens_hsa04726	0.77881945
53	GABAergic synapse_Homo sapiens_hsa04727	0.74328929
54	Alcoholism_Homo sapiens_hsa05034	0.73414711
55	RNA transport_Homo sapiens_hsa03013	0.72065187
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71724116
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.71039089
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70560836
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69488597
60	Cocaine addiction_Homo sapiens_hsa05030	0.67649121
61	Peroxisome_Homo sapiens_hsa04146	0.66817736
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66260733
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.65394034
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64731411
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63900816
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58922088
67	Salivary secretion_Homo sapiens_hsa04970	0.56964580
68	Viral myocarditis_Homo sapiens_hsa05416	0.55810734
69	Purine metabolism_Homo sapiens_hsa00230	0.55016489
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54987759
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51573713
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50153165
73	Metabolic pathways_Homo sapiens_hsa01100	0.50024006
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.48645381
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48397652
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.47463236
77	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.46665938
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.45222340
79	Gastric acid secretion_Homo sapiens_hsa04971	0.44827272
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.44798304
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43576062
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.40619097
83	Spliceosome_Homo sapiens_hsa03040	0.39337602
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37450734
85	Antigen processing and presentation_Homo sapiens_hsa04612	0.37114469
86	ABC transporters_Homo sapiens_hsa02010	0.37063839
87	Propanoate metabolism_Homo sapiens_hsa00640	0.36424003
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.35633502
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.34890884
90	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.34449722
91	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.29839360
92	Cholinergic synapse_Homo sapiens_hsa04725	0.27920300
93	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.26252030
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25860002
95	Insulin secretion_Homo sapiens_hsa04911	0.23728525
96	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23562611
97	RNA degradation_Homo sapiens_hsa03018	0.23446457
98	Amphetamine addiction_Homo sapiens_hsa05031	0.23100968
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.22322792
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.22120571

MAP2K1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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