MAP2K2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.84519360
2L-phenylalanine metabolic process (GO:0006558)4.84519360
3negative regulation of erythrocyte differentiation (GO:0045647)4.56002837
4glycine metabolic process (GO:0006544)4.55876265
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.38446587
6L-phenylalanine catabolic process (GO:0006559)4.33424996
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.33424996
8protein localization to endosome (GO:0036010)4.27049259
9regulation of cholesterol esterification (GO:0010872)4.14948273
10DNA deamination (GO:0045006)4.07534688
11viral transcription (GO:0019083)4.03660472
12cysteine metabolic process (GO:0006534)3.95003779
13sulfur amino acid catabolic process (GO:0000098)3.93528529
14glyoxylate metabolic process (GO:0046487)3.90858615
15serine family amino acid biosynthetic process (GO:0009070)3.85312064
16lysine catabolic process (GO:0006554)3.81801385
17lysine metabolic process (GO:0006553)3.81801385
18translational termination (GO:0006415)3.81147936
19serine family amino acid metabolic process (GO:0009069)3.80032185
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.75128018
21serine family amino acid catabolic process (GO:0009071)3.71861062
22apoptotic process involved in morphogenesis (GO:0060561)3.69872000
23mannose metabolic process (GO:0006013)3.64639936
24positive regulation of Cdc42 GTPase activity (GO:0043089)3.60972724
25barbed-end actin filament capping (GO:0051016)3.58306525
26regulation of mammary gland epithelial cell proliferation (GO:0033599)3.57729476
27aromatic amino acid family catabolic process (GO:0009074)3.53486216
284-hydroxyproline metabolic process (GO:0019471)3.53153964
29translational elongation (GO:0006414)3.51126392
30folic acid-containing compound biosynthetic process (GO:0009396)3.45852567
31negative regulation of sterol transport (GO:0032372)3.43549454
32negative regulation of cholesterol transport (GO:0032375)3.43549454
33regulation of cholesterol homeostasis (GO:2000188)3.41898557
34activation of Rac GTPase activity (GO:0032863)3.41517139
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.41340147
36negative regulation of fibrinolysis (GO:0051918)3.37688248
37L-serine metabolic process (GO:0006563)3.37262055
38folic acid metabolic process (GO:0046655)3.36848581
39modulation by symbiont of host cellular process (GO:0044068)3.34150449
40protein targeting to ER (GO:0045047)3.33360540
41kynurenine metabolic process (GO:0070189)3.31699646
42cotranslational protein targeting to membrane (GO:0006613)3.28642290
43positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.27613551
44positive regulation of lipoprotein lipase activity (GO:0051006)3.24884681
45positive regulation of triglyceride lipase activity (GO:0061365)3.24884681
46intestinal cholesterol absorption (GO:0030299)3.24614718
47proline biosynthetic process (GO:0006561)3.24402706
48maternal placenta development (GO:0001893)3.23385359
49cell-substrate adherens junction assembly (GO:0007045)3.20782882
50focal adhesion assembly (GO:0048041)3.20782882
51heme biosynthetic process (GO:0006783)3.20498627
52positive regulation of histone deacetylation (GO:0031065)3.18226712
53adherens junction assembly (GO:0034333)3.17699278
54pentose-phosphate shunt (GO:0006098)3.17286365
55modulation by virus of host process (GO:0019054)3.17009745
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16510667
57* regulation of early endosome to late endosome transport (GO:2000641)3.15851334
58protein localization to endoplasmic reticulum (GO:0070972)3.15079613
59positive regulation of triglyceride metabolic process (GO:0090208)3.12557006
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10410794
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10318881
62positive regulation of fatty acid biosynthetic process (GO:0045723)3.10265569
63positive regulation of triglyceride biosynthetic process (GO:0010867)3.10126466
64pteridine-containing compound biosynthetic process (GO:0042559)3.09372370
65activation of MAPKKK activity (GO:0000185)3.08658311
66amino-acid betaine metabolic process (GO:0006577)3.05212684
67translational initiation (GO:0006413)3.04955605
68viral life cycle (GO:0019058)3.03544822
69proline metabolic process (GO:0006560)3.03052147
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02551754
71cell-cell junction maintenance (GO:0045217)3.02427624
72alpha-linolenic acid metabolic process (GO:0036109)3.02059181
73cellular ketone body metabolic process (GO:0046950)3.00008192
74aspartate family amino acid catabolic process (GO:0009068)2.98041850
75heme transport (GO:0015886)2.96445481
76regulation of fibrinolysis (GO:0051917)2.96174671
77regulation of triglyceride catabolic process (GO:0010896)2.96161682
78stress fiber assembly (GO:0043149)2.93971849
79NIK/NF-kappaB signaling (GO:0038061)2.92961702
80positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.92331985
81protein carboxylation (GO:0018214)2.91925206
82peptidyl-glutamic acid carboxylation (GO:0017187)2.91925206
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91406923
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.91406923
85modulation by symbiont of host immune response (GO:0052553)2.91406923
86positive regulation by symbiont of host defense response (GO:0052509)2.91406923
87modulation by symbiont of host defense response (GO:0052031)2.91406923
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91406923
892-oxoglutarate metabolic process (GO:0006103)2.91326806
90planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90997398
91intestinal absorption (GO:0050892)2.90129720
92COPI coating of Golgi vesicle (GO:0048205)2.89723129
93Golgi transport vesicle coating (GO:0048200)2.89723129
94cellular modified amino acid catabolic process (GO:0042219)2.89677779
95aromatic amino acid family metabolic process (GO:0009072)2.88954446
96protein retention in ER lumen (GO:0006621)2.87277836
97indole-containing compound catabolic process (GO:0042436)2.86590187
98indolalkylamine catabolic process (GO:0046218)2.86590187
99tryptophan catabolic process (GO:0006569)2.86590187
100nucleoside salvage (GO:0043174)2.86229695
101regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85907523
102regulation of glucose import in response to insulin stimulus (GO:2001273)2.85762692
103adhesion of symbiont to host (GO:0044406)2.85595596
104cellular protein complex disassembly (GO:0043624)2.83965269
105NADPH regeneration (GO:0006740)2.83430401
106negative regulation of cell size (GO:0045792)2.82135297
107homocysteine metabolic process (GO:0050667)2.81747284
108high-density lipoprotein particle remodeling (GO:0034375)2.81734126
109UV protection (GO:0009650)2.81666017
110regulation of defense response to virus by virus (GO:0050690)2.81664010
111porphyrin-containing compound biosynthetic process (GO:0006779)2.81280798
112alpha-amino acid catabolic process (GO:1901606)2.81203864
113ribosomal small subunit biogenesis (GO:0042274)2.80625961
114intracellular estrogen receptor signaling pathway (GO:0030520)2.80564584
115positive regulation of protein dephosphorylation (GO:0035307)2.80313083
116urea cycle (GO:0000050)2.80250868
117urea metabolic process (GO:0019627)2.80250868
118plasma lipoprotein particle clearance (GO:0034381)2.79984048
119semaphorin-plexin signaling pathway (GO:0071526)2.79407411
120mitochondrial calcium ion transport (GO:0006851)2.78025193
121regulation of extracellular matrix disassembly (GO:0010715)2.77919768
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.76846691
123heme metabolic process (GO:0042168)2.76812081
124tooth mineralization (GO:0034505)2.74562172
125purine nucleotide salvage (GO:0032261)2.74130445
126cellular amino acid catabolic process (GO:0009063)2.73462159
127fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72483833
128cholesterol homeostasis (GO:0042632)2.72192723
129nitrogen cycle metabolic process (GO:0071941)2.72038725
130vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.70799366
131basement membrane organization (GO:0071711)2.70741975
132virion attachment to host cell (GO:0019062)2.70160866
133adhesion of symbiont to host cell (GO:0044650)2.70160866
134antigen processing and presentation of endogenous antigen (GO:0019883)2.70155456
135negative regulation of fatty acid transport (GO:2000192)2.69657033
136regulation of chromatin binding (GO:0035561)2.69083555
137cell-substrate junction assembly (GO:0007044)2.68970058
138maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68817542
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.67102562
140nucleotide salvage (GO:0043173)2.66244281
141cellular response to virus (GO:0098586)2.66205627
142regulation of protein activation cascade (GO:2000257)2.65642150
143tryptophan metabolic process (GO:0006568)2.65406410
144sterol homeostasis (GO:0055092)2.64970707
145tetrahydrofolate metabolic process (GO:0046653)2.64120925
146negative regulation of viral release from host cell (GO:1902187)2.62611321
147negative regulation of cell killing (GO:0031342)2.62391270
148negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62391270
149fatty acid beta-oxidation (GO:0006635)2.62356981
150folic acid-containing compound metabolic process (GO:0006760)2.62096941
151protein targeting to plasma membrane (GO:0072661)2.61856115
152tricarboxylic acid metabolic process (GO:0072350)2.61580956
153bile acid biosynthetic process (GO:0006699)2.61526591
154ketone body metabolic process (GO:1902224)2.61260179
155protein complex disassembly (GO:0043241)2.60691493
156glucose 6-phosphate metabolic process (GO:0051156)2.60595693
157acylglycerol homeostasis (GO:0055090)2.60129086
158triglyceride homeostasis (GO:0070328)2.60129086
159positive regulation of blood vessel endothelial cell migration (GO:0043536)2.59767114
160response to mercury ion (GO:0046689)2.59759370
1613-UTR-mediated mRNA stabilization (GO:0070935)2.58525117
162modulation by virus of host morphology or physiology (GO:0019048)2.57361159
163GDP-mannose metabolic process (GO:0019673)2.57007755
164endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.56859582
165regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53181797
166positive regulation of receptor recycling (GO:0001921)2.50817883
167pinocytosis (GO:0006907)2.49325077
168glucose catabolic process (GO:0006007)2.49180895
169positive regulation of myotube differentiation (GO:0010831)2.48814798
170positive thymic T cell selection (GO:0045059)2.48078348
171apoptotic process involved in development (GO:1902742)2.47953963
172negative regulation of necroptotic process (GO:0060546)2.45538228
173response to laminar fluid shear stress (GO:0034616)2.45513138
174regulation of ARF GTPase activity (GO:0032312)2.43916911
175regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.43417104
176regulation of NFAT protein import into nucleus (GO:0051532)2.41571819
177positive regulation of protein deacetylation (GO:0090312)2.41361519
178intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.40934943
179positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40096947
180regulation of type I interferon-mediated signaling pathway (GO:0060338)2.37389819
181response to peptidoglycan (GO:0032494)2.36758619
182regulation of necrotic cell death (GO:0010939)2.35030257
183NADH metabolic process (GO:0006734)2.34434085
184activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.34318130
185thymic T cell selection (GO:0045061)2.33955857
186signal complex assembly (GO:0007172)2.31555030
187activation of JUN kinase activity (GO:0007257)2.30958248
188embryonic process involved in female pregnancy (GO:0060136)2.30844958
189cortical actin cytoskeleton organization (GO:0030866)2.29633742
190epithelial cell-cell adhesion (GO:0090136)2.29474997
191skin morphogenesis (GO:0043589)2.26551238
192regulation of protein dephosphorylation (GO:0035304)2.25355198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.42531487
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49873346
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.48960540
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.02728554
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00744623
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.50886277
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30118212
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.07459751
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06994495
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06725188
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.04965882
12TCF7_22412390_ChIP-Seq_EML_Mouse1.99300054
13MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97773976
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94351797
15LXR_22292898_ChIP-Seq_THP-1_Human1.92009806
16LXR_22158963_ChIP-Seq_LIVER_Mouse1.91380336
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89727885
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.86429645
19KDM2B_26808549_Chip-Seq_K562_Human1.86208446
20* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83395841
21VDR_21846776_ChIP-Seq_THP-1_Human1.82351104
22SRY_22984422_ChIP-ChIP_TESTIS_Rat1.79123264
23XRN2_22483619_ChIP-Seq_HELA_Human1.76055681
24MYC_22102868_ChIP-Seq_BL_Human1.74280527
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72924666
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72630565
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72423985
28ZNF263_19887448_ChIP-Seq_K562_Human1.67457169
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65616525
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65357096
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63967455
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62201212
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61068547
34VDR_24763502_ChIP-Seq_THP-1_Human1.60639314
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.57439826
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54132346
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53059973
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.52956797
39RACK7_27058665_Chip-Seq_MCF-7_Human1.51161532
40* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49998321
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48887509
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.48529081
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.47155964
44SMC4_20622854_ChIP-Seq_HELA_Human1.46074249
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.45996423
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45110983
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43815924
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43724887
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43007198
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.42124465
51* MAF_26560356_Chip-Seq_TH1_Human1.41944515
52P68_20966046_ChIP-Seq_HELA_Human1.40955856
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40622541
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38379937
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37408777
56* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36826276
57ATF3_27146783_Chip-Seq_COLON_Human1.36241301
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35329746
59DCP1A_22483619_ChIP-Seq_HELA_Human1.35210102
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.34390500
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33079686
62BCOR_27268052_Chip-Seq_Bcells_Human1.32030486
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31899784
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31427143
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31336646
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31006179
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29277843
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29271762
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.28677586
70UTX_26944678_Chip-Seq_JUKART_Human1.27987144
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27185407
72BCL6_27268052_Chip-Seq_Bcells_Human1.27061242
73* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27006409
74CTCF_27219007_Chip-Seq_Bcells_Human1.25496844
75* GABP_19822575_ChIP-Seq_HepG2_Human1.25472133
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.25292336
77TP53_22127205_ChIP-Seq_IMR90_Human1.24425898
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24224325
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24108714
80CLOCK_20551151_ChIP-Seq_293T_Human1.23171816
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.23114903
82* RUNX1_22412390_ChIP-Seq_EML_Mouse1.22776537
83* NCOR1_26117541_ChIP-Seq_K562_Human1.22213824
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20502596
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20062713
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.18527518
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18297843
88* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17897471
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17468697
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17439688
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17439472
92CIITA_25753668_ChIP-Seq_RAJI_Human1.16873361
93CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15822921
94* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15408089
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14741846
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.13661011
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12262792
98* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12210787
99* KDM2B_26808549_Chip-Seq_DND41_Human1.11860423
100* PHF8_20622854_ChIP-Seq_HELA_Human1.11260163
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11103948
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.10916559
103CTCF_21964334_Chip-Seq_Bcells_Human1.10716501
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10055069
105MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10002609
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09643095
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09497536
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08888763
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08337291
110* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08260012
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07273998
112* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07143398
113* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06919696
114CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06746533
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06648603
116OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06257966
117* RARA_24833708_ChIP-Seq_LIVER_Mouse1.05571118
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05017449
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03945018
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03113355
121SA1_27219007_Chip-Seq_Bcells_Human1.02907938
122CTCF_26484167_Chip-Seq_Bcells_Mouse1.02806277
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02778177
124* E2F1_20622854_ChIP-Seq_HELA_Human1.02768264
125* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01600427
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01287304
127TP63_22573176_ChIP-Seq_HFKS_Human1.01174150
128MAF_26560356_Chip-Seq_TH2_Human1.01120834
129* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99449057
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97457137
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97130965
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97087503
133ETS1_21867929_ChIP-Seq_TH2_Mouse0.97076715
134CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96623962
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96533259
136ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96000024
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95084646
138CREB1_26743006_Chip-Seq_LNCaP_Human0.94602416
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94442389
140STAT1_20625510_ChIP-Seq_HELA_Human0.94413088
141EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94382588
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94325655
143CTCF_20526341_ChIP-Seq_ESCs_Human0.94254900
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93786269
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92991595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.12233527
2MP0005360_urolithiasis5.01142823
3MP0009840_abnormal_foam_cell4.63226120
4MP0005365_abnormal_bile_salt3.51828269
5MP0003806_abnormal_nucleotide_metabolis3.48270669
6MP0004858_abnormal_nervous_system3.47164019
7MP0005085_abnormal_gallbladder_physiolo3.28922203
8MP0005083_abnormal_biliary_tract3.04236657
9MP0008875_abnormal_xenobiotic_pharmacok2.66399891
10MP0002877_abnormal_melanocyte_morpholog2.46104508
11MP0001666_abnormal_nutrient_absorption2.38668163
12MP0005076_abnormal_cell_differentiation2.27611078
13MP0003705_abnormal_hypodermis_morpholog2.24189878
14MP0003191_abnormal_cellular_cholesterol2.21581182
15MP0005332_abnormal_amino_acid2.20870201
16MP0003436_decreased_susceptibility_to2.20666271
17MP0003172_abnormal_lysosome_physiology2.10919380
18MP0010329_abnormal_lipoprotein_level2.07121668
19MP0005377_hearing/vestibular/ear_phenot2.02695947
20MP0003878_abnormal_ear_physiology2.02695947
21MP0003693_abnormal_embryo_hatching1.94260150
22MP0003656_abnormal_erythrocyte_physiolo1.88053669
23MP0004510_myositis1.84766333
24MP0003252_abnormal_bile_duct1.80799103
25MP0005409_darkened_coat_color1.80028802
26MP0003329_amyloid_beta_deposits1.73131713
27MP0003453_abnormal_keratinocyte_physiol1.72768791
28MP0000609_abnormal_liver_physiology1.68378796
29MP0003566_abnormal_cell_adhesion1.66335566
30MP0009643_abnormal_urine_homeostasis1.61089154
31MP0004233_abnormal_muscle_weight1.60249581
32MP0006036_abnormal_mitochondrial_physio1.58545465
33MP0003195_calcinosis1.56752797
34MP0010234_abnormal_vibrissa_follicle1.56258315
35MP0000685_abnormal_immune_system1.52529765
36MP0005451_abnormal_body_composition1.50232147
37MP0004947_skin_inflammation1.49969268
38MP0003279_aneurysm1.49913031
39MP0004019_abnormal_vitamin_homeostasis1.47231348
40MP0002249_abnormal_larynx_morphology1.47037543
41MP0000858_altered_metastatic_potential1.46033193
42MP0000750_abnormal_muscle_regeneration1.45306837
43MP0005319_abnormal_enzyme/_coenzyme1.45046686
44MP0003091_abnormal_cell_migration1.35697173
45MP0002118_abnormal_lipid_homeostasis1.33574269
46MP0002837_dystrophic_cardiac_calcinosis1.33286995
47MP0005220_abnormal_exocrine_pancreas1.29362702
48MP0003123_paternal_imprinting1.28084391
49MP0003283_abnormal_digestive_organ1.27086010
50MP0001958_emphysema1.26998828
51MP0010030_abnormal_orbit_morphology1.25914822
52MP0005636_abnormal_mineral_homeostasis1.24258995
53MP0000749_muscle_degeneration1.23294372
54MP0005623_abnormal_meninges_morphology1.22884321
55MP0003186_abnormal_redox_activity1.21166805
56MP0002269_muscular_atrophy1.16158839
57MP0000013_abnormal_adipose_tissue1.15484579
58MP0005058_abnormal_lysosome_morphology1.15339954
59MP0005387_immune_system_phenotype1.13436521
60MP0001790_abnormal_immune_system1.13436521
61MP0001873_stomach_inflammation1.13115843
62MP0005025_abnormal_response_to1.11955772
63MP0000604_amyloidosis1.11633103
64MP0005670_abnormal_white_adipose1.10684173
65MP0008438_abnormal_cutaneous_collagen1.10654937
66MP0003879_abnormal_hair_cell1.10463389
67MP0002998_abnormal_bone_remodeling1.09123235
68MP0000598_abnormal_liver_morphology1.07437814
69MP0005666_abnormal_adipose_tissue1.06113333
70MP0004130_abnormal_muscle_cell1.05063664
71MP0009053_abnormal_anal_canal1.04532412
72MP0001533_abnormal_skeleton_physiology1.04139811
73MP0004185_abnormal_adipocyte_glucose1.04087149
74MP0000747_muscle_weakness1.04076930
75MP0002419_abnormal_innate_immunity1.03901354
76MP0003075_altered_response_to1.03140996
77MP0004043_abnormal_pH_regulation1.02498743
78MP0002653_abnormal_ependyma_morphology1.02234603
79MP0003868_abnormal_feces_composition1.00972097
80MP0005501_abnormal_skin_physiology0.99005122
81MP0000681_abnormal_thyroid_gland0.98398518
82MP0003646_muscle_fatigue0.97834799
83MP0004957_abnormal_blastocyst_morpholog0.97715111
84MP0001849_ear_inflammation0.96358872
85MP0000462_abnormal_digestive_system0.95922567
86MP0005375_adipose_tissue_phenotype0.95261887
87MP0001756_abnormal_urination0.93920025
88MP0006035_abnormal_mitochondrial_morpho0.93693989
89MP0000358_abnormal_cell_content/0.92413214
90MP0005000_abnormal_immune_tolerance0.91472885
91MP0010155_abnormal_intestine_physiology0.90741704
92MP0000751_myopathy0.90146367
93MP0002060_abnormal_skin_morphology0.89957951
94MP0003111_abnormal_nucleus_morphology0.89584068
95MP0000767_abnormal_smooth_muscle0.87990744
96MP0000003_abnormal_adipose_tissue0.86722367
97MP0005464_abnormal_platelet_physiology0.86205250
98MP0005330_cardiomyopathy0.85628344
99MP0001663_abnormal_digestive_system0.85073985
100MP0003183_abnormal_peptide_metabolism0.84724172
101MP0005390_skeleton_phenotype0.84032726
102MP0003303_peritoneal_inflammation0.83599460
103MP0002138_abnormal_hepatobiliary_system0.83143066
104MP0001542_abnormal_bone_strength0.82780419
105MP0005584_abnormal_enzyme/coenzyme_acti0.81910870
106MP0003763_abnormal_thymus_physiology0.81762029
107MP0005084_abnormal_gallbladder_morpholo0.81413606
108MP0009672_abnormal_birth_weight0.80426647
109MP0005166_decreased_susceptibility_to0.79854250
110MP0000759_abnormal_skeletal_muscle0.79625283
111MP0002796_impaired_skin_barrier0.79311537
112MP0001730_embryonic_growth_arrest0.79028053
113MP0000490_abnormal_crypts_of0.78010045
114MP0009333_abnormal_splenocyte_physiolog0.77662478
115MP0001944_abnormal_pancreas_morphology0.77639528
116MP0002420_abnormal_adaptive_immunity0.75889617
117MP0001819_abnormal_immune_cell0.75854313
118MP0008874_decreased_physiological_sensi0.75817285
119MP0009931_abnormal_skin_appearance0.75781406
120MP0004859_abnormal_synaptic_plasticity0.74079608
121MP0000343_altered_response_to0.73478740
122MP0009278_abnormal_bone_marrow0.73309121
123MP0001835_abnormal_antigen_presentation0.73173806
124MP0002148_abnormal_hypersensitivity_rea0.72553954
125MP0002896_abnormal_bone_mineralization0.72294745
126MP0004087_abnormal_muscle_fiber0.71728268
127MP0002723_abnormal_immune_serum0.71514956
128MP0009642_abnormal_blood_homeostasis0.71452387
129MP0000537_abnormal_urethra_morphology0.71111849
130MP0005257_abnormal_intraocular_pressure0.71006991
131MP0002234_abnormal_pharynx_morphology0.70254810
132MP0003634_abnormal_glial_cell0.70137000
133MP0002452_abnormal_antigen_presenting0.68572523
134MP0003718_maternal_effect0.68272334
135MP0004381_abnormal_hair_follicle0.67774234
136MP0000467_abnormal_esophagus_morphology0.67632616
137MP0004272_abnormal_basement_membrane0.67391162
138MP0004808_abnormal_hematopoietic_stem0.66762341
139MP0002254_reproductive_system_inflammat0.65595812
140MP0000477_abnormal_intestine_morphology0.65109647
141MP0002398_abnormal_bone_marrow0.64951777
142MP0002971_abnormal_brown_adipose0.64699748
143MP0002078_abnormal_glucose_homeostasis0.64413511
144MP0002080_prenatal_lethality0.64156524
145MP0001800_abnormal_humoral_immune0.64119863
146MP0003119_abnormal_digestive_system0.63265632
147MP0003300_gastrointestinal_ulcer0.63047222
148MP0009379_abnormal_foot_pigmentation0.62287930
149MP0000733_abnormal_muscle_development0.62017142
150MP0005023_abnormal_wound_healing0.61356714
151MP0001348_abnormal_lacrimal_gland0.60352664
152MP0003315_abnormal_perineum_morphology0.59955441
153MP0005381_digestive/alimentary_phenotyp0.59669303
154MP0008469_abnormal_protein_level0.59066584
155MP0003011_delayed_dark_adaptation0.58342319
156MP0002089_abnormal_postnatal_growth/wei0.57494175
157MP0000678_abnormal_parathyroid_gland0.56724411
158MP0008260_abnormal_autophagy0.56181735
159MP0002136_abnormal_kidney_physiology0.56124489
160MP0001661_extended_life_span0.55866437
161MP0008932_abnormal_embryonic_tissue0.55015582
162MP0002111_abnormal_tail_morphology0.54702383

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.77761802
2Xanthomatosis (HP:0000991)4.12491488
3Abnormality of monocarboxylic acid metabolism (HP:0010996)3.79638588
4Hypobetalipoproteinemia (HP:0003563)3.72219951
5Deep venous thrombosis (HP:0002625)3.50997842
6Hyperglycinuria (HP:0003108)3.40643000
7Hypoglycemic coma (HP:0001325)3.38736533
8Hyperacusis (HP:0010780)3.38076851
9Late onset (HP:0003584)3.30569913
10Hyperglycinemia (HP:0002154)3.25521216
11Hyperammonemia (HP:0001987)3.22717585
12Ketosis (HP:0001946)3.18968370
13Abnormality of glycine metabolism (HP:0010895)3.18730713
14Abnormality of serine family amino acid metabolism (HP:0010894)3.18730713
15Intrahepatic cholestasis (HP:0001406)3.18339337
16Vertebral compression fractures (HP:0002953)3.18084810
17Abnormality of fatty-acid metabolism (HP:0004359)3.08506848
18Dicarboxylic aciduria (HP:0003215)3.00261769
19Abnormality of dicarboxylic acid metabolism (HP:0010995)3.00261769
20Hyperlipoproteinemia (HP:0010980)2.97988785
21Hypolipoproteinemia (HP:0010981)2.94943873
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91707239
23Progressive muscle weakness (HP:0003323)2.91376248
24Distal lower limb muscle weakness (HP:0009053)2.82210401
25Gout (HP:0001997)2.81400810
26Distal lower limb amyotrophy (HP:0008944)2.78248812
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.75427652
28Type 1 muscle fiber predominance (HP:0003803)2.71975412
29Abnormality of cells of the erythroid lineage (HP:0012130)2.71403382
30Cerebral aneurysm (HP:0004944)2.69871862
31Ileus (HP:0002595)2.69617537
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.67673161
33Increased variability in muscle fiber diameter (HP:0003557)2.67142168
34Prolonged partial thromboplastin time (HP:0003645)2.65478678
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.64018783
36Hepatic necrosis (HP:0002605)2.61921644
37Upper limb amyotrophy (HP:0009129)2.61497095
38Distal upper limb amyotrophy (HP:0007149)2.61497095
39Obstructive sleep apnea (HP:0002870)2.59020216
40Rhabdomyolysis (HP:0003201)2.58956168
41Hypoalphalipoproteinemia (HP:0003233)2.57761421
42Thin bony cortex (HP:0002753)2.54592007
43Myoglobinuria (HP:0002913)2.54226303
44Myopathic facies (HP:0002058)2.52805450
45Multiple enchondromatosis (HP:0005701)2.52619563
46Abnormality of the Achilles tendon (HP:0005109)2.52078290
47Generalized aminoaciduria (HP:0002909)2.51049691
48Macrocytic anemia (HP:0001972)2.51000325
49Ketoacidosis (HP:0001993)2.49322925
50Abnormality of skeletal muscle fiber size (HP:0012084)2.49287302
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.47031079
52Stridor (HP:0010307)2.46739520
53Disproportionate tall stature (HP:0001519)2.46203977
54Abnormal number of erythroid precursors (HP:0012131)2.45459836
55Fragile skin (HP:0001030)2.44806437
56Lethargy (HP:0001254)2.41892518
57Increased serum ferritin (HP:0003281)2.40844932
58Abnormal cartilage morphology (HP:0002763)2.38047921
59Broad face (HP:0000283)2.37112547
60Reticulocytosis (HP:0001923)2.36722555
61Ulnar bowing (HP:0003031)2.31934819
62Difficulty climbing stairs (HP:0003551)2.31424676
63Premature rupture of membranes (HP:0001788)2.30026811
64Cellulitis (HP:0100658)2.28759058
65Insomnia (HP:0100785)2.27189856
66Achilles tendon contracture (HP:0001771)2.26784047
67Protrusio acetabuli (HP:0003179)2.26568677
68Eczematoid dermatitis (HP:0000976)2.25558117
69Hyperbilirubinemia (HP:0002904)2.25396393
70Spinal rigidity (HP:0003306)2.25241246
71Hyperparathyroidism (HP:0000843)2.23654957
72Emphysema (HP:0002097)2.23318033
73Abnormality of pyrimidine metabolism (HP:0004353)2.22899552
74Brushfield spots (HP:0001088)2.20398107
75Mildly elevated creatine phosphokinase (HP:0008180)2.19518824
76Mitral regurgitation (HP:0001653)2.19384421
77Abnormality of the thoracic spine (HP:0100711)2.19106530
78Polycythemia (HP:0001901)2.19042357
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17998132
80Abnormality of reticulocytes (HP:0004312)2.17596440
81Axonal loss (HP:0003447)2.16943578
82Opisthotonus (HP:0002179)2.15549341
83Hepatocellular necrosis (HP:0001404)2.14195755
84Abnormality of transition element cation homeostasis (HP:0011030)2.13429655
85Genu recurvatum (HP:0002816)2.12750978
86Abnormality of the intrinsic pathway (HP:0010989)2.12698683
87Abnormality of glycolipid metabolism (HP:0010969)2.11836765
88Abnormality of liposaccharide metabolism (HP:0010968)2.11836765
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.11836765
90Back pain (HP:0003418)2.11270017
91Malnutrition (HP:0004395)2.10974107
92Abnormality of serum amino acid levels (HP:0003112)2.09447392
93Dysostosis multiplex (HP:0000943)2.09266035
94Exercise-induced myalgia (HP:0003738)2.08851629
95Abnormality of nucleobase metabolism (HP:0010932)2.08329793
96Shallow orbits (HP:0000586)2.07702752
97Abnormality of the common coagulation pathway (HP:0010990)2.07500279
98Abnormality of iron homeostasis (HP:0011031)2.06408166
99Poikilocytosis (HP:0004447)2.06283167
100Cervical subluxation (HP:0003308)2.06282864
101Polygenic inheritance (HP:0010982)2.04707601
102Blue sclerae (HP:0000592)2.03689245
103Decreased subcutaneous fat (HP:0001002)2.03355212
104Increased cerebral lipofuscin (HP:0011813)2.03170876
105Hemorrhage of the eye (HP:0011885)2.02937397
106Hypercortisolism (HP:0001578)2.02786493
107Bulbar palsy (HP:0001283)2.02107268
108Trismus (HP:0000211)2.01331517
109Abnormality of purine metabolism (HP:0004352)2.01044913
110Acanthocytosis (HP:0001927)2.00805804
111Ankle contracture (HP:0006466)1.96851331
112Slender build (HP:0001533)1.96841790
113Round ear (HP:0100830)1.96523572
114CNS demyelination (HP:0007305)1.95955694
115Rectal prolapse (HP:0002035)1.95407286
116Cerebral inclusion bodies (HP:0100314)1.95247177
117Metabolic acidosis (HP:0001942)1.94726698
118Flat acetabular roof (HP:0003180)1.94498298
119Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94371710
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94371710
121J-shaped sella turcica (HP:0002680)1.93951420
122Biconcave vertebral bodies (HP:0004586)1.93906905
123Gastrointestinal stroma tumor (HP:0100723)1.93222701
124Cholelithiasis (HP:0001081)1.92529074
125Thoracic kyphosis (HP:0002942)1.92520767
126Irritability (HP:0000737)1.92268919
127Cerebral edema (HP:0002181)1.91736091
128Ventricular tachycardia (HP:0004756)1.91025667
129Bladder diverticulum (HP:0000015)1.90543440
130Supranuclear gaze palsy (HP:0000605)1.90031298
131Asymmetric septal hypertrophy (HP:0001670)1.89113141
132Easy fatigability (HP:0003388)1.88337047
133Abnormality of methionine metabolism (HP:0010901)1.88303569
134Obstructive lung disease (HP:0006536)1.88023706
135Chronic obstructive pulmonary disease (HP:0006510)1.88023706
136Lower limb amyotrophy (HP:0007210)1.87305890
137Abnormality of subcutaneous fat tissue (HP:0001001)1.87034984
138Broad distal phalanx of finger (HP:0009836)1.86299728
139Insulin resistance (HP:0000855)1.86144773
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.85288404
141Delayed CNS myelination (HP:0002188)1.85167155
142Generalized amyotrophy (HP:0003700)1.84960681
143Abnormality of urine glucose concentration (HP:0011016)1.84690275
144Glycosuria (HP:0003076)1.84690275
145Complement deficiency (HP:0004431)1.83989568
146Abnormality of macrophages (HP:0004311)1.83844012
147Reticulocytopenia (HP:0001896)1.83594456
148Microretrognathia (HP:0000308)1.83029212
149Cholecystitis (HP:0001082)1.82684791
150Abnormal gallbladder physiology (HP:0012438)1.82684791
151Testicular atrophy (HP:0000029)1.81605161
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81509686
153Fat malabsorption (HP:0002630)1.81388234
154Abnormality of the nasal mucosa (HP:0000433)1.81080277
155Hand muscle atrophy (HP:0009130)1.80944961
156Hepatocellular carcinoma (HP:0001402)1.80769030
157Ragged-red muscle fibers (HP:0003200)1.80729538
158Turricephaly (HP:0000262)1.80358736
159Elbow flexion contracture (HP:0002987)1.80036733
160Ulnar deviation of the wrist (HP:0003049)1.79846449
161Vomiting (HP:0002013)1.78525432
162Oral leukoplakia (HP:0002745)1.78409635
163Abnormal gallbladder morphology (HP:0012437)1.78105794
164Neonatal onset (HP:0003623)1.77855069
165Segmental peripheral demyelination/remyelination (HP:0003481)1.77194255
166Global brain atrophy (HP:0002283)1.77086183
167Abnormality of complement system (HP:0005339)1.76580639
168Upper motor neuron abnormality (HP:0002127)1.76569301
169Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74705978
170Hypercholesterolemia (HP:0003124)1.74481598
171Entropion (HP:0000621)1.74427901
172Aneurysm (HP:0002617)1.74284193
173Neurofibrillary tangles (HP:0002185)1.74246208
174Joint hemorrhage (HP:0005261)1.73801540
175Hyperinsulinemic hypoglycemia (HP:0000825)1.72998382
176Increased connective tissue (HP:0009025)1.72141823
177Hypertensive crisis (HP:0100735)1.71767243
178Abnormality of the distal phalanges of the toes (HP:0010182)1.70719817
179Dilatation of the ascending aorta (HP:0005111)1.69018316
180Hyperthyroidism (HP:0000836)1.68703623
181Premature skin wrinkling (HP:0100678)1.62478117
182Hypercalcemia (HP:0003072)1.62085019
183Visual hallucinations (HP:0002367)1.61764361
184Short nail (HP:0001799)1.61292268
185Truncus arteriosus (HP:0001660)1.60788342
186Coxa vara (HP:0002812)1.59997006
187Atrophic scars (HP:0001075)1.58783879
188Pathologic fracture (HP:0002756)1.58140920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.48206478
2ERN13.88925790
3BCKDK3.84272513
4NME23.75045097
5SMG13.44086584
6MAP3K103.34894436
7PRPF4B3.15338521
8TESK23.09922577
9BUB12.72723840
10PKN22.55103592
11TLK12.36399475
12MAP3K112.22591096
13BLK1.87770729
14RIPK11.84490695
15TESK11.82634132
16DYRK31.80241807
17PIM21.68574700
18TTN1.57716632
19MAP3K131.56817130
20STK161.53356381
21KDR1.53103792
22EEF2K1.50248960
23PTK61.50062295
24ICK1.46997041
25FGFR41.39119185
26LIMK11.38940000
27EPHA21.37646427
28SIK11.35872549
29KSR21.34109302
30TAOK11.27952524
31RPS6KA21.27495718
32PAK41.27486584
33LRRK21.26437499
34FLT31.24356281
35RIPK41.23875377
36DYRK1B1.22435795
37RPS6KA41.21715269
38NME11.21294738
39MARK21.21069803
40IRAK41.19038390
41MST1R1.17060292
42NEK21.16788595
43* MAP2K21.16661297
44CDK121.15963768
45SCYL21.15495576
46EIF2AK11.14175297
47PRKD31.08267588
48CDC42BPA1.06261731
49MAPKAPK31.04483988
50ILK1.01100221
51DAPK30.99946950
52RPS6KC10.94995488
53RPS6KL10.94995488
54DDR20.92462011
55ABL20.92131938
56AURKA0.90880669
57LATS20.90638972
58MAP4K10.90266367
59MAPK110.89778082
60PDGFRA0.87794232
61BMX0.87536548
62IRAK20.86579548
63TAOK20.86338621
64PTK20.86124508
65MAP2K30.86100522
66MAP3K30.85592609
67EPHB10.85448911
68WEE10.85359460
69HIPK20.85312806
70* PDPK10.84343839
71SIK20.83001474
72PASK0.79444255
73PRKCI0.79280005
74EPHB20.78299960
75MOS0.77892624
76RPS6KA60.77700481
77PIK3CG0.76879411
78TBK10.76879029
79MET0.76283584
80PAK10.75344398
81PAK20.75000325
82MTOR0.74055276
83MAP3K90.73158519
84MAPK120.70697845
85ZAP700.67491787
86TYRO30.66205281
87MAPK150.65343866
88RPS6KB20.64364728
89GRK60.64031008
90NTRK10.63518622
91WNK40.63438464
92AKT20.63163870
93IRAK30.62942151
94LMTK20.62338453
95CDK70.62277190
96DYRK20.62153646
97MAP2K10.58520031
98CAMKK10.58132400
99TNK20.57436929
100PAK60.55695045
101CDK40.55647702
102NEK10.54623099
103PRKD10.54260406
104ARAF0.53338948
105DMPK0.49834975
106* MAP3K80.48828780
107CSK0.48630805
108PINK10.46478084
109TYK20.45924869
110ERBB20.44614707
111STK380.43931521
112MAP3K60.43815277
113AURKB0.43369885
114* PDK10.42612275
115PHKG20.42469016
116PHKG10.42469016
117JAK30.41125796
118CAMK1D0.40816798
119STK100.38426007
120RPS6KA10.37836440
121MAP3K140.35804737
122PRKG20.35785087
123PRKCH0.35632952
124MAPKAPK20.35544316
125SGK30.35190319
126CDK11A0.34040006
127PRKD20.34038729
128IRAK10.33900597
129TTK0.32081859
130SIK30.31122845
131BTK0.31010094
132PLK10.30893705
133RPS6KA50.30247902
134MAP3K10.30076633
135MAPK40.27675608
136MAP3K70.26917464
137PAK30.25814550
138CAMK2G0.25255883
139TAOK30.24954771
140GSK3A0.24250459
141CDK190.23716170

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.18250044
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62447273
3Folate biosynthesis_Homo sapiens_hsa007902.55683882
4Ribosome_Homo sapiens_hsa030102.45571927
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44791929
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40604585
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.33252269
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23297649
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.22403044
10Fatty acid degradation_Homo sapiens_hsa000712.17609939
11Fat digestion and absorption_Homo sapiens_hsa049752.16043189
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09327323
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.06640249
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06347313
15Tryptophan metabolism_Homo sapiens_hsa003802.04597653
16Selenocompound metabolism_Homo sapiens_hsa004502.01259457
17Notch signaling pathway_Homo sapiens_hsa043301.92882189
18Sulfur metabolism_Homo sapiens_hsa009201.90178319
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88053808
20* Acute myeloid leukemia_Homo sapiens_hsa052211.84279717
21Arginine biosynthesis_Homo sapiens_hsa002201.84089360
22Nitrogen metabolism_Homo sapiens_hsa009101.80352054
23* Chronic myeloid leukemia_Homo sapiens_hsa052201.79295018
24* VEGF signaling pathway_Homo sapiens_hsa043701.77964054
25* B cell receptor signaling pathway_Homo sapiens_hsa046621.68267136
26Butanoate metabolism_Homo sapiens_hsa006501.68102999
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64624537
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.64471504
29Carbon metabolism_Homo sapiens_hsa012001.63450877
30Biosynthesis of amino acids_Homo sapiens_hsa012301.62899461
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.59507661
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58345047
33Arginine and proline metabolism_Homo sapiens_hsa003301.56777307
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50001131
35Osteoclast differentiation_Homo sapiens_hsa043801.48830456
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.43985020
37* Non-small cell lung cancer_Homo sapiens_hsa052231.42707492
38Peroxisome_Homo sapiens_hsa041461.41674922
39Propanoate metabolism_Homo sapiens_hsa006401.39682864
40Pentose phosphate pathway_Homo sapiens_hsa000301.39130939
41* Central carbon metabolism in cancer_Homo sapiens_hsa052301.37974882
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37943715
43Pancreatic cancer_Homo sapiens_hsa052121.36408543
44PPAR signaling pathway_Homo sapiens_hsa033201.35723504
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35616563
46One carbon pool by folate_Homo sapiens_hsa006701.35206217
47Fatty acid metabolism_Homo sapiens_hsa012121.34126379
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33729683
49* Neurotrophin signaling pathway_Homo sapiens_hsa047221.32017226
50Histidine metabolism_Homo sapiens_hsa003401.29912392
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28679893
52Pyruvate metabolism_Homo sapiens_hsa006201.26964211
53beta-Alanine metabolism_Homo sapiens_hsa004101.23099948
54Vitamin B6 metabolism_Homo sapiens_hsa007501.22778695
55* Prion diseases_Homo sapiens_hsa050201.21945685
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20417355
57* Insulin signaling pathway_Homo sapiens_hsa049101.20179472
58* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18574898
59Complement and coagulation cascades_Homo sapiens_hsa046101.18508451
60Glutathione metabolism_Homo sapiens_hsa004801.17399799
61Leishmaniasis_Homo sapiens_hsa051401.15252897
62mTOR signaling pathway_Homo sapiens_hsa041501.14552458
63Proteasome_Homo sapiens_hsa030501.14045726
64* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12867936
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12656582
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12343818
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11538623
68Galactose metabolism_Homo sapiens_hsa000521.10955231
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10825382
70Lysosome_Homo sapiens_hsa041421.10616455
71Fructose and mannose metabolism_Homo sapiens_hsa000511.06618267
72Pyrimidine metabolism_Homo sapiens_hsa002401.05218352
73* Glioma_Homo sapiens_hsa052141.04883469
74* GnRH signaling pathway_Homo sapiens_hsa049121.04364554
75Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04295739
76TNF signaling pathway_Homo sapiens_hsa046681.04000215
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03832643
78DNA replication_Homo sapiens_hsa030301.03090885
79Hepatitis C_Homo sapiens_hsa051601.02818378
80Starch and sucrose metabolism_Homo sapiens_hsa005001.01842197
81Endocytosis_Homo sapiens_hsa041441.01079442
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00170059
83Focal adhesion_Homo sapiens_hsa045100.98679682
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97975439
85Toxoplasmosis_Homo sapiens_hsa051450.97753018
86Caffeine metabolism_Homo sapiens_hsa002320.97713756
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97510279
88* Endometrial cancer_Homo sapiens_hsa052130.97162472
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96856978
90Chemical carcinogenesis_Homo sapiens_hsa052040.96283615
91AMPK signaling pathway_Homo sapiens_hsa041520.95775599
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95578849
93Parkinsons disease_Homo sapiens_hsa050120.95293309
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.95114019
95* Renal cell carcinoma_Homo sapiens_hsa052110.94731162
96Amoebiasis_Homo sapiens_hsa051460.94458533
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94275615
98* ErbB signaling pathway_Homo sapiens_hsa040120.92462120
99Vibrio cholerae infection_Homo sapiens_hsa051100.91954077
100Salmonella infection_Homo sapiens_hsa051320.91783940
101Tuberculosis_Homo sapiens_hsa051520.91766807
102* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91464383
103* Apoptosis_Homo sapiens_hsa042100.91324446
104* Phospholipase D signaling pathway_Homo sapiens_hsa040720.87928533
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87587602
106Lysine degradation_Homo sapiens_hsa003100.87159245
107Oxidative phosphorylation_Homo sapiens_hsa001900.87025465
108Bile secretion_Homo sapiens_hsa049760.85768455
109Insulin resistance_Homo sapiens_hsa049310.84392659
110RNA polymerase_Homo sapiens_hsa030200.83378837
111Fatty acid elongation_Homo sapiens_hsa000620.83223779
112Synaptic vesicle cycle_Homo sapiens_hsa047210.83133601
113Vitamin digestion and absorption_Homo sapiens_hsa049770.82055585
114Shigellosis_Homo sapiens_hsa051310.80797485
115HTLV-I infection_Homo sapiens_hsa051660.80764921
116Phenylalanine metabolism_Homo sapiens_hsa003600.78405238
117Viral myocarditis_Homo sapiens_hsa054160.78354836
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77443687
119* Hepatitis B_Homo sapiens_hsa051610.77246503
120* Sphingolipid signaling pathway_Homo sapiens_hsa040710.76566247
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76469199
122* Proteoglycans in cancer_Homo sapiens_hsa052050.75798112
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75572236
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.74687468
125Chemokine signaling pathway_Homo sapiens_hsa040620.74603002
126* Estrogen signaling pathway_Homo sapiens_hsa049150.74457768
127Viral carcinogenesis_Homo sapiens_hsa052030.73638106
128* Influenza A_Homo sapiens_hsa051640.72628377
129Metabolic pathways_Homo sapiens_hsa011000.72327729
130Retinol metabolism_Homo sapiens_hsa008300.70103576
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.69273588
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69138514
133Small cell lung cancer_Homo sapiens_hsa052220.68789292
134* T cell receptor signaling pathway_Homo sapiens_hsa046600.68697455
135Malaria_Homo sapiens_hsa051440.67381846
136Glycerolipid metabolism_Homo sapiens_hsa005610.67340829
137* MAPK signaling pathway_Homo sapiens_hsa040100.66382078
138Protein export_Homo sapiens_hsa030600.64862338
139Tyrosine metabolism_Homo sapiens_hsa003500.64830463
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64005698
141ABC transporters_Homo sapiens_hsa020100.61931898
142Inositol phosphate metabolism_Homo sapiens_hsa005620.61449055
143Nucleotide excision repair_Homo sapiens_hsa034200.61424981
144Spliceosome_Homo sapiens_hsa030400.60740378
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60456121
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59412927
147* Long-term potentiation_Homo sapiens_hsa047200.59020023
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58350177
149Colorectal cancer_Homo sapiens_hsa052100.58227393
150* Prolactin signaling pathway_Homo sapiens_hsa049170.58113413
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57313590
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56802883
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56772080
154* HIF-1 signaling pathway_Homo sapiens_hsa040660.55247494
155Linoleic acid metabolism_Homo sapiens_hsa005910.54630236
156Base excision repair_Homo sapiens_hsa034100.54110115
157* Choline metabolism in cancer_Homo sapiens_hsa052310.54066602
158Huntingtons disease_Homo sapiens_hsa050160.52153984
159* Prostate cancer_Homo sapiens_hsa052150.50443151
160* Thyroid cancer_Homo sapiens_hsa052160.50120185
161Glucagon signaling pathway_Homo sapiens_hsa049220.49051327
162* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48786077
163Dilated cardiomyopathy_Homo sapiens_hsa054140.48567111
164Herpes simplex infection_Homo sapiens_hsa051680.47705623
165* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47031660
166Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46513042
167Staphylococcus aureus infection_Homo sapiens_hsa051500.46403061
168Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46375572
169Other glycan degradation_Homo sapiens_hsa005110.45520311
170* Rap1 signaling pathway_Homo sapiens_hsa040150.43931627
171* Bladder cancer_Homo sapiens_hsa052190.42827763
172Mismatch repair_Homo sapiens_hsa034300.42155821
173Glycosaminoglycan degradation_Homo sapiens_hsa005310.41388885
174Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39811388
175Glycerophospholipid metabolism_Homo sapiens_hsa005640.39276586
176Alzheimers disease_Homo sapiens_hsa050100.38399655
177Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37925061
178RNA transport_Homo sapiens_hsa030130.34530278
179Cardiac muscle contraction_Homo sapiens_hsa042600.33948759
180Steroid biosynthesis_Homo sapiens_hsa001000.32370984
181N-Glycan biosynthesis_Homo sapiens_hsa005100.31767602
182Adipocytokine signaling pathway_Homo sapiens_hsa049200.29078667
183Renin-angiotensin system_Homo sapiens_hsa046140.28461817
184Purine metabolism_Homo sapiens_hsa002300.28243655

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