MAP2K3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.15555639
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.15555639
3macrophage activation involved in immune response (GO:0002281)3.82205675
4lipopolysaccharide-mediated signaling pathway (GO:0031663)3.62745227
5detection of other organism (GO:0098543)3.58327353
6detection of bacterium (GO:0016045)3.46194924
7germinal center formation (GO:0002467)3.35021970
8granulocyte activation (GO:0036230)3.31349099
9negative regulation of cytokine production involved in immune response (GO:0002719)3.28898446
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15731800
11regulation of interleukin-12 biosynthetic process (GO:0045075)3.15063677
12cellular response to type I interferon (GO:0071357)3.14919336
13type I interferon signaling pathway (GO:0060337)3.14919336
14regulation of T-helper 2 cell differentiation (GO:0045628)3.14299335
15response to type I interferon (GO:0034340)3.10978749
16neutrophil activation (GO:0042119)3.10387377
17detection of external biotic stimulus (GO:0098581)3.09972041
18regulation of interferon-beta biosynthetic process (GO:0045357)3.07416542
19detection of molecule of bacterial origin (GO:0032490)3.04642045
20cellular extravasation (GO:0045123)3.02277844
21regulation of mast cell degranulation (GO:0043304)3.02159829
22defense response to protozoan (GO:0042832)2.98259540
23response to protozoan (GO:0001562)2.98155578
24myeloid dendritic cell differentiation (GO:0043011)2.94231469
25positive regulation of chemokine biosynthetic process (GO:0045080)2.92506994
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91761708
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91761708
28myeloid cell activation involved in immune response (GO:0002275)2.88593602
29positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86162696
30regulation of podosome assembly (GO:0071801)2.85284488
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83072592
32detection of biotic stimulus (GO:0009595)2.81636949
33regulation of chemokine biosynthetic process (GO:0045073)2.77065078
34positive regulation of gamma-delta T cell activation (GO:0046645)2.75834652
35response to host immune response (GO:0052572)2.75610814
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75610814
37macrophage activation (GO:0042116)2.75004420
38regulation of leukocyte degranulation (GO:0043300)2.74808374
39regulation of T-helper 1 cell differentiation (GO:0045625)2.73340107
40positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.72420189
41interferon-gamma-mediated signaling pathway (GO:0060333)2.72269630
42regulation of B cell receptor signaling pathway (GO:0050855)2.71303585
43cellular glucuronidation (GO:0052695)2.69634699
44regulation of mast cell activation involved in immune response (GO:0033006)2.69311973
45negative regulation of T cell mediated immunity (GO:0002710)2.69274464
46negative regulation of lymphocyte mediated immunity (GO:0002707)2.69115374
47negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.68394204
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.67816599
49valine metabolic process (GO:0006573)2.67387827
50positive regulation of type 2 immune response (GO:0002830)2.66655973
51myeloid dendritic cell activation (GO:0001773)2.65551283
52response to host (GO:0075136)2.65060111
53response to host defenses (GO:0052200)2.65060111
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65060111
55regulation of mononuclear cell migration (GO:0071675)2.63566953
56regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63108116
57respiratory burst (GO:0045730)2.62928645
58regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62867384
59Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62530542
60low-density lipoprotein particle clearance (GO:0034383)2.62268461
61negative regulation of interleukin-6 production (GO:0032715)2.61337969
62negative regulation of leukocyte mediated immunity (GO:0002704)2.60757939
63modulation by symbiont of host cellular process (GO:0044068)2.60413114
64regulation of type 2 immune response (GO:0002828)2.59828139
65protein localization to endosome (GO:0036010)2.57406182
66negative regulation of production of molecular mediator of immune response (GO:0002701)2.56869329
67regulation of necrotic cell death (GO:0010939)2.56760806
68regulation of T cell tolerance induction (GO:0002664)2.56677642
69T cell apoptotic process (GO:0070231)2.55147362
70antigen processing and presentation of endogenous antigen (GO:0019883)2.54694662
71ribosomal small subunit assembly (GO:0000028)2.54530916
72negative regulation of myeloid cell apoptotic process (GO:0033033)2.53541986
73regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.51439427
743-UTR-mediated mRNA stabilization (GO:0070935)2.49684624
75cellular response to thyroid hormone stimulus (GO:0097067)2.47966880
76purine nucleotide salvage (GO:0032261)2.47868034
77negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47031907
78positive regulation of NF-kappaB import into nucleus (GO:0042346)2.46735741
79uronic acid metabolic process (GO:0006063)2.46681933
80glucuronate metabolic process (GO:0019585)2.46681933
81regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44994794
82negative regulation of interleukin-12 production (GO:0032695)2.44603936
83negative regulation of necroptotic process (GO:0060546)2.44069487
84neutrophil mediated immunity (GO:0002446)2.43916769
85regulation of interleukin-6 production (GO:0032675)2.43839502
86positive regulation of Cdc42 GTPase activity (GO:0043089)2.43801780
87regulation of tolerance induction (GO:0002643)2.42080094
88NIK/NF-kappaB signaling (GO:0038061)2.40367548
89folic acid-containing compound biosynthetic process (GO:0009396)2.35514925
90positive regulation of B cell differentiation (GO:0045579)2.35481983
91peptidyl-glutamic acid carboxylation (GO:0017187)2.34919568
92protein carboxylation (GO:0018214)2.34919568
93positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.33692746
94regulation of vitamin D biosynthetic process (GO:0060556)2.33085040
95positive regulation of natural killer cell differentiation (GO:0032825)2.32119762
96negative regulation of fibrinolysis (GO:0051918)2.31347644
97positive regulation of lipid storage (GO:0010884)2.29795635
98triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.29077512
99pinocytosis (GO:0006907)2.28057881
100positive regulation of interferon-alpha production (GO:0032727)2.27456593
101regulation of gamma-delta T cell differentiation (GO:0045586)2.26384235
102immunoglobulin mediated immune response (GO:0016064)2.25721578
103regulation of gamma-delta T cell activation (GO:0046643)2.25103183
104AMP metabolic process (GO:0046033)2.24591248
105hepatocyte apoptotic process (GO:0097284)2.24162194
106fibrinolysis (GO:0042730)2.21444253
107negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.20018687
108primary alcohol catabolic process (GO:0034310)2.19568610
109xenobiotic catabolic process (GO:0042178)2.18829361
110plasma lipoprotein particle clearance (GO:0034381)2.18792524
111negative regulation of cholesterol transport (GO:0032375)2.17894496
112negative regulation of sterol transport (GO:0032372)2.17894496
113leukocyte aggregation (GO:0070486)2.17746445
114lymphocyte apoptotic process (GO:0070227)2.17499951
115regulation of interferon-alpha production (GO:0032647)2.17485260
116response to muramyl dipeptide (GO:0032495)2.16724904
117response to nitrosative stress (GO:0051409)2.16645324
118response to peptidoglycan (GO:0032494)2.16200874
119sulfur amino acid catabolic process (GO:0000098)2.15178212
120regulation of cholesterol storage (GO:0010885)2.12463620
121aldehyde catabolic process (GO:0046185)2.12105992
122glycine metabolic process (GO:0006544)2.09815975
123regulation of vitamin metabolic process (GO:0030656)2.08903437
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.05813903
125cellular response to virus (GO:0098586)2.04466507
126positive regulation of lipoprotein lipase activity (GO:0051006)2.04130689
127positive regulation of triglyceride lipase activity (GO:0061365)2.04130689
128neutrophil activation involved in immune response (GO:0002283)2.03747154
129regulation of triglyceride catabolic process (GO:0010896)2.03336229
130negative regulation of phagocytosis (GO:0050765)2.03194375
131fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.03182352
132regulation of necroptotic process (GO:0060544)2.02413842
133positive regulation of extracellular matrix organization (GO:1903055)2.02180964
134nucleotide salvage (GO:0043173)2.02112727
135positive regulation of isotype switching (GO:0045830)2.01869564
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.00313017
137purine-containing compound salvage (GO:0043101)1.99777330
138viral transcription (GO:0019083)1.99625509
139folic acid metabolic process (GO:0046655)1.99391352
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)1.99281042
141positive regulation of blood coagulation (GO:0030194)1.99080530
142positive regulation of hemostasis (GO:1900048)1.99080530
143wound healing, spreading of epidermal cells (GO:0035313)1.98756885
144regulation of cytokine secretion involved in immune response (GO:0002739)1.98497542
145modulation by symbiont of host defense response (GO:0052031)1.98389381
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.98389381
147modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.98389381
148positive regulation by organism of defense response of other organism involved in symbiotic interact1.98389381
149modulation by symbiont of host immune response (GO:0052553)1.98389381
150positive regulation by symbiont of host defense response (GO:0052509)1.98389381
151positive regulation of immunoglobulin mediated immune response (GO:0002891)1.97497068
152positive regulation of B cell mediated immunity (GO:0002714)1.97497068
153leukocyte apoptotic process (GO:0071887)1.97427457
154nucleoside salvage (GO:0043174)1.97242817
155regulation of natural killer cell differentiation (GO:0032823)1.97082491
156B cell mediated immunity (GO:0019724)1.96305364
157regulation of response to interferon-gamma (GO:0060330)1.95353012
158amino-acid betaine metabolic process (GO:0006577)1.95035347
159cysteine metabolic process (GO:0006534)1.94592733
160pentose-phosphate shunt (GO:0006098)1.94064669
161positive regulation of coagulation (GO:0050820)1.93922762
162translational termination (GO:0006415)1.93817745
163positive regulation of reactive oxygen species metabolic process (GO:2000379)1.92874502
164positive regulation of macrophage differentiation (GO:0045651)1.92857489
165regulation of metalloenzyme activity (GO:0048552)1.92537365
166negative regulation of erythrocyte differentiation (GO:0045647)1.92064248
167folic acid transport (GO:0015884)1.91948895
168cellular response to nicotine (GO:0071316)1.91938219
169positive regulation of protein import into nucleus, translocation (GO:0033160)1.91873942
170serine family amino acid biosynthetic process (GO:0009070)1.91538399
171regulation of plasminogen activation (GO:0010755)1.91213443
172urea cycle (GO:0000050)1.89808925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.55657020
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.27919630
3E2F7_22180533_ChIP-Seq_HELA_Human3.13446236
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91595854
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70714408
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.62030217
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54971727
8* RXR_22158963_ChIP-Seq_LIVER_Mouse2.50200255
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.50143146
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.47606923
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.38712568
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08771492
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05166799
14* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03451547
15* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00075645
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.95893288
17SPI1_23127762_ChIP-Seq_K562_Human1.91548620
18* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90493623
19LXR_22292898_ChIP-Seq_THP-1_Human1.87869224
20* MYC_22102868_ChIP-Seq_BL_Human1.87659398
21* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83548505
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83196597
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81904654
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81141926
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.78002742
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.77738327
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74776176
28GATA1_19941826_ChIP-Seq_K562_Human1.73645399
29* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69398068
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67582779
31* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67178416
32* KDM2B_26808549_Chip-Seq_DND41_Human1.67112394
33* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66090743
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64595287
35RUNX_20019798_ChIP-Seq_JUKART_Human1.64523889
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63436403
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62932985
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61547572
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.60257448
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57695975
41* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57008570
42VDR_21846776_ChIP-Seq_THP-1_Human1.55214158
43MAF_26560356_Chip-Seq_TH1_Human1.54735961
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53930788
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51846183
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.51608148
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51393200
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.49762522
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48527492
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47629682
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45463166
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44781866
53CLOCK_20551151_ChIP-Seq_293T_Human1.43961971
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43746284
55SCL_19346495_ChIP-Seq_HPC-7_Human1.38894286
56* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38816848
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38180760
58* SPI1_23547873_ChIP-Seq_NB4_Human1.35802813
59* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35632612
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.35247205
61* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33414433
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33354345
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31099595
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30898643
65* RUNX1_22412390_ChIP-Seq_EML_Mouse1.29919631
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.29704093
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28991569
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28823865
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28439710
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27957534
71VDR_24787735_ChIP-Seq_THP-1_Human1.27852757
72VDR_24763502_ChIP-Seq_THP-1_Human1.27184748
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26551158
74GATA1_22025678_ChIP-Seq_K562_Human1.26352044
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25939517
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.25530662
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.24542640
78MYB_26560356_Chip-Seq_TH2_Human1.22835382
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22237828
80MYB_26560356_Chip-Seq_TH1_Human1.21077143
81* UTX_26944678_Chip-Seq_JUKART_Human1.20969769
82* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20479895
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19893584
84* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18836707
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18504054
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17709136
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17527230
88* ATF3_27146783_Chip-Seq_COLON_Human1.17415588
89* PU_27001747_Chip-Seq_BMDM_Mouse1.16617895
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15834651
91* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15448732
92TCF7_22412390_ChIP-Seq_EML_Mouse1.14983000
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14967188
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14696173
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14421942
96* GATA2_19941826_ChIP-Seq_K562_Human1.13504337
97AR_21909140_ChIP-Seq_LNCAP_Human1.12600024
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11962534
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11918622
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11778687
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11734583
102MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10677013
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10116657
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.10106885
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09829415
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09016041
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08907799
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08750122
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07551197
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07341871
111* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07322431
112* BCOR_27268052_Chip-Seq_Bcells_Human1.07112127
113* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06842350
114* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06754603
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06393488
116* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06195424
117* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05354388
118* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05354388
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04608123
120* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04274930
121* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04060797
122* BCL6_27268052_Chip-Seq_Bcells_Human1.03950061
123NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00869532
124* RACK7_27058665_Chip-Seq_MCF-7_Human1.00863349
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.00822404
126ZNF263_19887448_ChIP-Seq_K562_Human1.00524972
127MAF_26560356_Chip-Seq_TH2_Human0.99936471
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98092590
129DCP1A_22483619_ChIP-Seq_HELA_Human0.97619214
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97102812
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96561438
132* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96557495
133* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94266128
134NCOR1_26117541_ChIP-Seq_K562_Human0.93393401
135TFEB_21752829_ChIP-Seq_HELA_Human0.91818505
136XRN2_22483619_ChIP-Seq_HELA_Human0.91320857
137E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90515947
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89861491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to2.67049874
2MP0005451_abnormal_body_composition2.65276499
3MP0005058_abnormal_lysosome_morphology2.60123780
4MP0003806_abnormal_nucleotide_metabolis2.44476014
5MP0005360_urolithiasis2.42672612
6MP0002139_abnormal_hepatobiliary_system2.32019607
7MP0003705_abnormal_hypodermis_morpholog2.26402182
8MP0009840_abnormal_foam_cell2.01065046
9MP0001835_abnormal_antigen_presentation1.99335145
10MP0001853_heart_inflammation1.95983161
11MP0003172_abnormal_lysosome_physiology1.89301533
12MP0009785_altered_susceptibility_to1.88390061
13MP0008260_abnormal_autophagy1.87585441
14MP0003191_abnormal_cellular_cholesterol1.86053292
15MP0003303_peritoneal_inflammation1.84832018
16MP0005085_abnormal_gallbladder_physiolo1.80023068
17MP0003724_increased_susceptibility_to1.71992582
18MP0003075_altered_response_to1.70307965
19MP0003300_gastrointestinal_ulcer1.69700771
20MP0000685_abnormal_immune_system1.66431160
21MP0010352_gastrointestinal_tract_polyps1.62747595
22MP0008875_abnormal_xenobiotic_pharmacok1.61891089
23MP0002396_abnormal_hematopoietic_system1.61003466
24MP0005365_abnormal_bile_salt1.60830004
25MP0001545_abnormal_hematopoietic_system1.59667238
26MP0005397_hematopoietic_system_phenotyp1.59667238
27MP0005083_abnormal_biliary_tract1.56423765
28MP0005023_abnormal_wound_healing1.53198876
29MP0003566_abnormal_cell_adhesion1.47980472
30MP0002405_respiratory_system_inflammati1.47225252
31MP0003186_abnormal_redox_activity1.47016698
32* MP0005025_abnormal_response_to1.46919143
33MP0003656_abnormal_erythrocyte_physiolo1.46753518
34MP0005464_abnormal_platelet_physiology1.46705338
35MP0002419_abnormal_innate_immunity1.43534209
36MP0002998_abnormal_bone_remodeling1.41975220
37MP0008004_abnormal_stomach_pH1.41942104
38MP0005000_abnormal_immune_tolerance1.41402356
39MP0004947_skin_inflammation1.39584031
40MP0001533_abnormal_skeleton_physiology1.39314744
41MP0010155_abnormal_intestine_physiology1.38463752
42MP0002148_abnormal_hypersensitivity_rea1.35286754
43MP0005166_decreased_susceptibility_to1.34032761
44MP0001790_abnormal_immune_system1.33831188
45MP0005387_immune_system_phenotype1.33831188
46MP0008438_abnormal_cutaneous_collagen1.33610102
47MP0009333_abnormal_splenocyte_physiolog1.32219955
48MP0002332_abnormal_exercise_endurance1.31832533
49MP0001800_abnormal_humoral_immune1.31370981
50MP0003763_abnormal_thymus_physiology1.29052349
51MP0000343_altered_response_to1.27382882
52MP0005275_abnormal_skin_tensile1.26980818
53MP0002452_abnormal_antigen_presenting1.26779458
54MP0003279_aneurysm1.26354721
55MP0000604_amyloidosis1.24803396
56MP0005310_abnormal_salivary_gland1.24396417
57MP0000858_altered_metastatic_potential1.20992165
58MP0000609_abnormal_liver_physiology1.20230558
59MP0002723_abnormal_immune_serum1.19896373
60MP0008469_abnormal_protein_level1.16734844
61MP0000465_gastrointestinal_hemorrhage1.16321266
62MP0010329_abnormal_lipoprotein_level1.16293020
63MP0002060_abnormal_skin_morphology1.14878142
64MP0001845_abnormal_inflammatory_respons1.14775737
65MP0009278_abnormal_bone_marrow1.14019631
66MP0009764_decreased_sensitivity_to1.13633651
67MP0002166_altered_tumor_susceptibility1.13570087
68MP0005319_abnormal_enzyme/_coenzyme1.12339022
69MP0000490_abnormal_crypts_of1.11705114
70MP0003091_abnormal_cell_migration1.11654033
71MP0006054_spinal_hemorrhage1.11169089
72MP0002933_joint_inflammation1.10701408
73MP0005164_abnormal_response_to1.10053580
74MP0005671_abnormal_response_to1.09690855
75MP0003252_abnormal_bile_duct1.09114575
76MP0001663_abnormal_digestive_system1.08794305
77MP0002138_abnormal_hepatobiliary_system1.08346675
78* MP0002420_abnormal_adaptive_immunity1.08321949
79MP0002254_reproductive_system_inflammat1.08054388
80* MP0001819_abnormal_immune_cell1.07900364
81MP0004808_abnormal_hematopoietic_stem1.07473576
82MP0003693_abnormal_embryo_hatching1.06450153
83MP0002132_abnormal_respiratory_system1.05272421
84MP0002398_abnormal_bone_marrow1.03972124
85MP0000689_abnormal_spleen_morphology1.03724595
86MP0002722_abnormal_immune_system1.01350951
87MP0010368_abnormal_lymphatic_system1.00756841
88MP0001243_abnormal_dermal_layer1.00112183
89MP0002877_abnormal_melanocyte_morpholog1.00090094
90MP0001542_abnormal_bone_strength0.99991769
91MP0001666_abnormal_nutrient_absorption0.98415429
92MP0001851_eye_inflammation0.98358337
93MP0001873_stomach_inflammation0.97473964
94MP0003453_abnormal_keratinocyte_physiol0.96771530
95MP0000750_abnormal_muscle_regeneration0.95415560
96MP0006082_CNS_inflammation0.95104546
97MP0002006_tumorigenesis0.95102446
98MP0003448_altered_tumor_morphology0.94143866
99MP0000716_abnormal_immune_system0.92898411
100MP0000598_abnormal_liver_morphology0.90858203
101MP0002429_abnormal_blood_cell0.90446978
102MP0004883_abnormal_blood_vessel0.88516786
103MP0003828_pulmonary_edema0.88216401
104MP0001216_abnormal_epidermal_layer0.87813199
105* MP0009763_increased_sensitivity_to0.87026836
106MP0003866_abnormal_defecation0.86773144
107MP0002796_impaired_skin_barrier0.86120606
108MP0005390_skeleton_phenotype0.83784069
109MP0000703_abnormal_thymus_morphology0.83477361
110MP0009643_abnormal_urine_homeostasis0.82943693
111MP0004782_abnormal_surfactant_physiolog0.82643505
112MP0005501_abnormal_skin_physiology0.80322035
113MP0003183_abnormal_peptide_metabolism0.79474999
114MP0004510_myositis0.77938625
115MP0009931_abnormal_skin_appearance0.77863179
116MP0002019_abnormal_tumor_incidence0.77226706
117MP0005670_abnormal_white_adipose0.76953710
118MP0005165_increased_susceptibility_to0.76782902
119MP0003795_abnormal_bone_structure0.76655311
120MP0005076_abnormal_cell_differentiation0.75707608
121MP0000749_muscle_degeneration0.75167192
122MP0005167_abnormal_blood-brain_barrier0.74616418
123MP0000249_abnormal_blood_vessel0.74229618
124MP0008874_decreased_physiological_sensi0.71023853
125MP0009765_abnormal_xenobiotic_induced0.69667344
126MP0005381_digestive/alimentary_phenotyp0.69057931
127MP0003690_abnormal_glial_cell0.68965006
128MP0003045_fibrosis0.68738531
129MP0004858_abnormal_nervous_system0.68260852
130MP0003329_amyloid_beta_deposits0.66485618
131MP0003221_abnormal_cardiomyocyte_apopto0.66408212

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.31345618
2Abnormality of liposaccharide metabolism (HP:0010968)4.31345618
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.31345618
4Retrobulbar optic neuritis (HP:0100654)3.60811098
5Optic neuritis (HP:0100653)3.60811098
6Eczematoid dermatitis (HP:0000976)3.26636179
7Dysostosis multiplex (HP:0000943)3.13128126
8Increased cerebral lipofuscin (HP:0011813)3.01516633
9Purpura (HP:0000979)2.99021138
10Chronic obstructive pulmonary disease (HP:0006510)2.99005285
11Obstructive lung disease (HP:0006536)2.99005285
12Loss of speech (HP:0002371)2.97620154
13Elevated erythrocyte sedimentation rate (HP:0003565)2.96110639
14Increased connective tissue (HP:0009025)2.78016983
15Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70441240
16Increased IgE level (HP:0003212)2.67372099
17Muscle fiber inclusion bodies (HP:0100299)2.66845887
18Myocardial infarction (HP:0001658)2.65920954
19Keratoconjunctivitis sicca (HP:0001097)2.65429106
20Xanthomatosis (HP:0000991)2.63063014
21Pustule (HP:0200039)2.62363782
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.61889453
23Vasculitis (HP:0002633)2.61773145
24Amyloidosis (HP:0011034)2.61477172
25Recurrent skin infections (HP:0001581)2.59978398
26Ulnar deviation of the wrist (HP:0003049)2.57760930
27Protrusio acetabuli (HP:0003179)2.57205408
28Peritonitis (HP:0002586)2.55678928
29Gingivitis (HP:0000230)2.55674489
30Meningitis (HP:0001287)2.55548863
31Pulmonary infiltrates (HP:0002113)2.55522954
32Recurrent abscess formation (HP:0002722)2.50885058
33Cellulitis (HP:0100658)2.50626980
34Deep venous thrombosis (HP:0002625)2.49087137
35Recurrent viral infections (HP:0004429)2.48504147
36Recurrent gram-negative bacterial infections (HP:0005420)2.47998629
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.47294042
38Abnormality of polysaccharide metabolism (HP:0011012)2.46543072
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46543072
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46543072
41Thrombocytosis (HP:0001894)2.46332581
42Increased IgM level (HP:0003496)2.44634916
43Nemaline bodies (HP:0003798)2.42740904
44Increased serum ferritin (HP:0003281)2.40019783
45Hypochromic microcytic anemia (HP:0004840)2.39704805
46Keratoconjunctivitis (HP:0001096)2.34843132
47Encephalitis (HP:0002383)2.32964975
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.32444850
49Type 1 muscle fiber predominance (HP:0003803)2.30846888
50Episodic fever (HP:0001954)2.30789664
51Recurrent bacterial skin infections (HP:0005406)2.29283846
52Mucopolysacchariduria (HP:0008155)2.28432985
53Urinary glycosaminoglycan excretion (HP:0003541)2.28432985
54Abnormality of iron homeostasis (HP:0011031)2.27317510
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.23245192
56Distal lower limb muscle weakness (HP:0009053)2.23211551
57Hepatosplenomegaly (HP:0001433)2.22299684
58Myositis (HP:0100614)2.21442518
59Premature rupture of membranes (HP:0001788)2.21292515
60Polycythemia (HP:0001901)2.21186578
61Rhabdomyolysis (HP:0003201)2.17536611
62Hypochromic anemia (HP:0001931)2.16529015
63Hypoalphalipoproteinemia (HP:0003233)2.15299313
64Right ventricular cardiomyopathy (HP:0011663)2.14837923
65Interstitial pulmonary disease (HP:0006530)2.13341661
66Epistaxis (HP:0000421)2.13271745
67Slow saccadic eye movements (HP:0000514)2.12647038
68Intrahepatic cholestasis (HP:0001406)2.12073653
69Microcytic anemia (HP:0001935)2.11913584
70T lymphocytopenia (HP:0005403)2.11791864
71Esophageal varix (HP:0002040)2.11166536
72Petechiae (HP:0000967)2.08987099
73Osteolytic defects of the hand bones (HP:0009699)2.08805524
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.08805524
75Abnormality of transition element cation homeostasis (HP:0011030)2.07636182
76Abnormality of the common coagulation pathway (HP:0010990)2.06254787
77Anorexia (HP:0002039)2.05924152
78Hypobetalipoproteinemia (HP:0003563)2.05775783
79Leukocytosis (HP:0001974)2.05588055
80Hypergammaglobulinemia (HP:0010702)2.04604223
81Joint hemorrhage (HP:0005261)2.04204212
82Vertebral compression fractures (HP:0002953)2.04159582
83Abnormal platelet function (HP:0011869)2.03983734
84Impaired platelet aggregation (HP:0003540)2.03983734
85Asymmetric septal hypertrophy (HP:0001670)2.03919519
86Hypolipoproteinemia (HP:0010981)2.03784584
87Chest pain (HP:0100749)2.03555244
88Gingival bleeding (HP:0000225)2.01893678
89Hemoptysis (HP:0002105)2.01048992
90Abnormality of T cell number (HP:0011839)2.00527004
91Autoimmune hemolytic anemia (HP:0001890)1.99764277
92Autoimmune thrombocytopenia (HP:0001973)1.99663966
93Disinhibition (HP:0000734)1.98323467
94Increased density of long bones (HP:0006392)1.98141474
95Gangrene (HP:0100758)1.97919295
96Distal arthrogryposis (HP:0005684)1.96761874
97Inflammation of the large intestine (HP:0002037)1.96446537
98Prolonged partial thromboplastin time (HP:0003645)1.96329985
99Nonimmune hydrops fetalis (HP:0001790)1.95628824
100Cupped ribs (HP:0000887)1.95617828
101Gastrointestinal inflammation (HP:0004386)1.94894235
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94473107
103Chronic mucocutaneous candidiasis (HP:0002728)1.94253021
104Recurrent cutaneous fungal infections (HP:0011370)1.94253021
105Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93803439
106Polyneuropathy (HP:0001271)1.93491922
107Abnormal cartilage morphology (HP:0002763)1.93369215
108Abnormal platelet volume (HP:0011876)1.93056496
109Nuclear cataract (HP:0100018)1.92731807
110Abnormality of complement system (HP:0005339)1.92413010
111Increased mean platelet volume (HP:0011877)1.91769257
112Distal lower limb amyotrophy (HP:0008944)1.90313246
113Stomatitis (HP:0010280)1.89288382
114Orchitis (HP:0100796)1.89159041
115Abnormality of pyrimidine metabolism (HP:0004353)1.88809840
116Hypertensive crisis (HP:0100735)1.88208312
117Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87974478
118Nausea (HP:0002018)1.87915193
119Spontaneous hematomas (HP:0007420)1.87583823
120Gastrointestinal infarctions (HP:0005244)1.87545050
121Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87487006
122Segmental peripheral demyelination/remyelination (HP:0003481)1.87341587
123Glomerulopathy (HP:0100820)1.86141525
124Systemic lupus erythematosus (HP:0002725)1.86136730
125Reduced subcutaneous adipose tissue (HP:0003758)1.84503598
126Progressive neurologic deterioration (HP:0002344)1.84048532
127Recurrent fungal infections (HP:0002841)1.83746388
128Hypertriglyceridemia (HP:0002155)1.83605280
129Abnormality of the nasal mucosa (HP:0000433)1.83600110
130Osteomyelitis (HP:0002754)1.82896654
131Abnormality of T cell physiology (HP:0011840)1.82175138
132Myopathic facies (HP:0002058)1.82150139
133Abnormality of the pericardium (HP:0001697)1.80842945
134Thrombophlebitis (HP:0004418)1.80492023
135Arterial thrombosis (HP:0004420)1.80187280
136Flat acetabular roof (HP:0003180)1.80035273
137Exercise-induced muscle cramps (HP:0003710)1.79216650
138Abnormality of macrophages (HP:0004311)1.78988331
139Menorrhagia (HP:0000132)1.78879226
140Axonal loss (HP:0003447)1.78784046
141Abnormal number of erythroid precursors (HP:0012131)1.78758112
142Hyperammonemia (HP:0001987)1.77903000
143Urticaria (HP:0001025)1.77884445
144Beaking of vertebral bodies (HP:0004568)1.77152996
145Abnormality of cells of the erythroid lineage (HP:0012130)1.76896239
146Myoglobinuria (HP:0002913)1.76426094
147Alopecia of scalp (HP:0002293)1.76343678
148Hypercholesterolemia (HP:0003124)1.75128623
149Difficulty climbing stairs (HP:0003551)1.75068693
150Multiple enchondromatosis (HP:0005701)1.75057774
151Hyperlipoproteinemia (HP:0010980)1.75048211
152Abnormality of fatty-acid metabolism (HP:0004359)1.72540288
153Mediastinal lymphadenopathy (HP:0100721)1.72244876
154Abnormality of the distal phalanges of the toes (HP:0010182)1.71449244
155Cervical subluxation (HP:0003308)1.69944836
156Entropion (HP:0000621)1.67009529
157Calcaneovalgus deformity (HP:0001848)1.64232801
158Vacuolated lymphocytes (HP:0001922)1.63959816
159Abnormality of the prostate (HP:0008775)1.62958117
160Abnormality of the intrinsic pathway (HP:0010989)1.62521687
161Abnormality of the calcaneus (HP:0008364)1.62349869
162Reduced antithrombin III activity (HP:0001976)1.61477519
163Abnormal foot bone ossification (HP:0010675)1.61019508
164Prolonged bleeding time (HP:0003010)1.60043370
165Ileus (HP:0002595)1.59984797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM23.55044587
2PRPF4B3.28184791
3RIPK43.22054330
4NME23.01228746
5ERN12.85918888
6TRIB32.73179253
7MAP4K12.65213399
8TBK12.21208186
9MAP3K142.18288475
10TTN2.10095319
11RPS6KA42.09526918
12PKN22.05971690
13ZAP701.86105468
14STK101.83836505
15JAK31.78749483
16FGR1.67425211
17IKBKB1.66020705
18TGFBR21.58317299
19GRK71.57266132
20TYK21.56811896
21KDR1.56656606
22FLT31.51589164
23RIPK11.51481623
24BCKDK1.49492405
25TEC1.49418964
26KIT1.46217484
27FES1.38880259
28TXK1.38321891
29MAP3K131.37775497
30PIM11.36347524
31MAP3K101.35533774
32LRRK21.34817208
33EEF2K1.34474499
34PIK3CG1.33709667
35IKBKE1.32572187
36BTK1.30890142
37TRPM71.29864681
38FGFR41.28294900
39MOS1.27612042
40TESK11.25233568
41* MAP2K31.23390856
42SMG11.22781299
43EPHA21.22173534
44NEK91.21756928
45* MAP3K31.20123281
46MAPKAPK31.19990782
47CHUK1.19878645
48CDC42BPA1.14328930
49IRAK31.13727427
50DDR21.10891502
51RPS6KB21.10802104
52TNK21.10584718
53* MAP3K11.08326810
54SIK31.07364284
55IRAK41.04491769
56MST41.03327782
57BLK1.02667862
58MARK31.01222585
59TGFBR11.01010752
60ITK1.00256320
61IRAK20.99694556
62BMPR20.98802135
63PTK60.96664878
64CDK60.95712466
65SIK10.95230248
66ICK0.94514161
67TESK20.93370323
68EIF2AK10.92461848
69PRKD20.92439093
70CSK0.91244109
71WEE10.90957991
72MST1R0.90889434
73OBSCN0.88197486
74IRAK10.88100774
75PAK40.87051904
76NLK0.85428837
77PRKG20.81708862
78BRSK20.78043584
79* TAOK20.77341548
80ABL20.76759213
81MARK20.75214325
82EPHB10.74825443
83ARAF0.74268351
84KSR20.73520401
85HIPK20.73204824
86PDPK10.72393319
87HCK0.71986055
88BUB10.70757295
89CDK40.70359394
90MAPK110.68539946
91MAP3K70.64895889
92JAK20.64416571
93CDK120.63945925
94TIE10.63943375
95MAPKAPK20.63564416
96ZAK0.62210903
97* MAP3K110.62183831
98RPS6KL10.62020612
99PDK10.61800325
100CSF1R0.60982710
101MAPK120.60622355
102* MAP3K80.59895678
103PAK20.59478316
104TAOK30.58174407
105CDK70.56394038
106SYK0.56223060
107JAK10.56114967
108LCK0.55170517
109LYN0.53827654
110STK40.53387724
111ILK0.52554555
112PTK2B0.51421464
113STK240.51369481
114GRK60.51137301
115RPS6KA60.50846009
116MAP2K60.50405203
117MAP2K20.49777098
118EPHA30.49116392
119AURKB0.47839299
120MATK0.46503515
121MAP3K60.45907957
122BMX0.44818328
123SCYL20.43965432
124NEK20.43167610
125EIF2AK30.42599620
126MAPK70.41997569
127MAPK40.40596551
128NEK10.39783768
129ABL10.39050419
130CLK10.38126602
131DYRK1B0.37949814
132MYLK0.37683206
133RPS6KC10.35506977
134RPS6KA20.34630979
135SGK30.33098382
136FYN0.30271134
137STK380.30091138
138DYRK30.29472438

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30015511
2Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20818439
3Caffeine metabolism_Homo sapiens_hsa002321.80026898
4Sulfur relay system_Homo sapiens_hsa041221.73030189
5Leishmaniasis_Homo sapiens_hsa051401.72558412
6Autoimmune thyroid disease_Homo sapiens_hsa053201.68515533
7Primary bile acid biosynthesis_Homo sapiens_hsa001201.68486288
8Staphylococcus aureus infection_Homo sapiens_hsa051501.67427536
9Lysosome_Homo sapiens_hsa041421.64870379
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64780278
11Rheumatoid arthritis_Homo sapiens_hsa053231.61840301
12Salmonella infection_Homo sapiens_hsa051321.61344302
13African trypanosomiasis_Homo sapiens_hsa051431.59224682
14Legionellosis_Homo sapiens_hsa051341.56907096
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55208813
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.54599787
17Complement and coagulation cascades_Homo sapiens_hsa046101.54513868
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54393944
19One carbon pool by folate_Homo sapiens_hsa006701.52277052
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.48956889
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48209569
22Fatty acid degradation_Homo sapiens_hsa000711.44081266
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43261588
24Chemical carcinogenesis_Homo sapiens_hsa052041.43019766
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.42226981
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38803712
27Ribosome_Homo sapiens_hsa030101.37775668
28DNA replication_Homo sapiens_hsa030301.35743475
29T cell receptor signaling pathway_Homo sapiens_hsa046601.35129260
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34404305
31Chemokine signaling pathway_Homo sapiens_hsa040621.30825236
32Type I diabetes mellitus_Homo sapiens_hsa049401.29449207
33Folate biosynthesis_Homo sapiens_hsa007901.28712743
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25572494
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22948041
36Starch and sucrose metabolism_Homo sapiens_hsa005001.22551580
37Phagosome_Homo sapiens_hsa041451.22023931
38Selenocompound metabolism_Homo sapiens_hsa004501.21317376
39Measles_Homo sapiens_hsa051621.15516618
40Glutathione metabolism_Homo sapiens_hsa004801.14084821
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13758498
42Malaria_Homo sapiens_hsa051441.13654411
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11452278
44Amoebiasis_Homo sapiens_hsa051461.11142505
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10176359
46Apoptosis_Homo sapiens_hsa042101.10081957
47Arginine biosynthesis_Homo sapiens_hsa002201.07591740
48* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06291052
49Tryptophan metabolism_Homo sapiens_hsa003801.06005311
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02924014
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02229825
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.01271211
53beta-Alanine metabolism_Homo sapiens_hsa004101.01065004
54Pentose phosphate pathway_Homo sapiens_hsa000301.00786022
55Osteoclast differentiation_Homo sapiens_hsa043801.00783647
56Pancreatic cancer_Homo sapiens_hsa052120.99943420
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98960148
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98929275
59Shigellosis_Homo sapiens_hsa051310.98892581
60VEGF signaling pathway_Homo sapiens_hsa043700.97494944
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97292572
62PPAR signaling pathway_Homo sapiens_hsa033200.97091270
63Retinol metabolism_Homo sapiens_hsa008300.96446137
64Hematopoietic cell lineage_Homo sapiens_hsa046400.96025419
65Proteasome_Homo sapiens_hsa030500.95749192
66Pertussis_Homo sapiens_hsa051330.95548725
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94629606
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.93532693
69Acute myeloid leukemia_Homo sapiens_hsa052210.93281662
70Galactose metabolism_Homo sapiens_hsa000520.93103138
71* Toxoplasmosis_Homo sapiens_hsa051450.92808021
72Primary immunodeficiency_Homo sapiens_hsa053400.91425256
73Antigen processing and presentation_Homo sapiens_hsa046120.91282431
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.91094023
75Herpes simplex infection_Homo sapiens_hsa051680.90494714
76Histidine metabolism_Homo sapiens_hsa003400.90118699
77* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89362195
78Carbon metabolism_Homo sapiens_hsa012000.88481114
79Peroxisome_Homo sapiens_hsa041460.88364238
80Prion diseases_Homo sapiens_hsa050200.88059046
81p53 signaling pathway_Homo sapiens_hsa041150.87924087
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87794193
83Non-small cell lung cancer_Homo sapiens_hsa052230.87776670
84* TNF signaling pathway_Homo sapiens_hsa046680.87598114
85Biosynthesis of amino acids_Homo sapiens_hsa012300.87114344
86Platelet activation_Homo sapiens_hsa046110.86908359
87Fat digestion and absorption_Homo sapiens_hsa049750.86593075
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85012811
89Base excision repair_Homo sapiens_hsa034100.84979981
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.83140301
91Small cell lung cancer_Homo sapiens_hsa052220.80720255
92Allograft rejection_Homo sapiens_hsa053300.79724877
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.78747641
94Chronic myeloid leukemia_Homo sapiens_hsa052200.77432542
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76098974
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75821892
97Prolactin signaling pathway_Homo sapiens_hsa049170.75632360
98Phenylalanine metabolism_Homo sapiens_hsa003600.74199960
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.74196052
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.74007890
101Pyrimidine metabolism_Homo sapiens_hsa002400.73500105
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72945855
103Asthma_Homo sapiens_hsa053100.72700930
104* Influenza A_Homo sapiens_hsa051640.71999970
105Viral myocarditis_Homo sapiens_hsa054160.71698042
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70558710
107* Epstein-Barr virus infection_Homo sapiens_hsa051690.70100178
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69370294
109Graft-versus-host disease_Homo sapiens_hsa053320.69343161
110Renal cell carcinoma_Homo sapiens_hsa052110.68286189
111Bladder cancer_Homo sapiens_hsa052190.67867413
112Endocytosis_Homo sapiens_hsa041440.67663895
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.67094231
114Arginine and proline metabolism_Homo sapiens_hsa003300.66855296
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66479804
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65037872
117Vitamin digestion and absorption_Homo sapiens_hsa049770.64810393
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.64413566
119* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64124293
120HTLV-I infection_Homo sapiens_hsa051660.63167029
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62794663
122Hepatitis B_Homo sapiens_hsa051610.62366027
123B cell receptor signaling pathway_Homo sapiens_hsa046620.61144765
124Tuberculosis_Homo sapiens_hsa051520.60792758
125Propanoate metabolism_Homo sapiens_hsa006400.59817021
126Hepatitis C_Homo sapiens_hsa051600.59353195
127Fructose and mannose metabolism_Homo sapiens_hsa000510.58468148
128Viral carcinogenesis_Homo sapiens_hsa052030.56863471
129Notch signaling pathway_Homo sapiens_hsa043300.56128645
130Other glycan degradation_Homo sapiens_hsa005110.53896056
131Sulfur metabolism_Homo sapiens_hsa009200.53068532
132HIF-1 signaling pathway_Homo sapiens_hsa040660.52611127
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51823541
134Fatty acid metabolism_Homo sapiens_hsa012120.51202347
135FoxO signaling pathway_Homo sapiens_hsa040680.51074309
136Insulin resistance_Homo sapiens_hsa049310.50984972
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50738637
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47725476
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.41779322
140Collecting duct acid secretion_Homo sapiens_hsa049660.41067827
141Endometrial cancer_Homo sapiens_hsa052130.39668029
142Insulin signaling pathway_Homo sapiens_hsa049100.35707911
143mTOR signaling pathway_Homo sapiens_hsa041500.35245768
144* MAPK signaling pathway_Homo sapiens_hsa040100.34777230
145Proteoglycans in cancer_Homo sapiens_hsa052050.33845614
146Type II diabetes mellitus_Homo sapiens_hsa049300.33716855
147Prostate cancer_Homo sapiens_hsa052150.32370373
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32196282
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30580226
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.29700497

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