MAP2K4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.00042200
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.97643051
3synaptic vesicle exocytosis (GO:0016079)5.60088550
4glutamate secretion (GO:0014047)5.54853684
5locomotory exploration behavior (GO:0035641)5.50819310
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.30590101
7regulation of synaptic vesicle exocytosis (GO:2000300)5.25867616
8vocalization behavior (GO:0071625)5.14229517
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.13619074
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.91473842
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90218453
12regulation of glutamate receptor signaling pathway (GO:1900449)4.69451570
13regulation of synaptic vesicle transport (GO:1902803)4.66288481
14neuronal action potential propagation (GO:0019227)4.63748471
15neurotransmitter secretion (GO:0007269)4.51046304
16exploration behavior (GO:0035640)4.46093435
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.41848788
18protein localization to synapse (GO:0035418)4.41246503
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.37128327
20layer formation in cerebral cortex (GO:0021819)4.31928013
21neuron cell-cell adhesion (GO:0007158)4.31596131
22regulation of neuronal synaptic plasticity (GO:0048168)4.25162694
23cerebellar granule cell differentiation (GO:0021707)4.12686155
24L-amino acid import (GO:0043092)4.06433641
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99779358
26proline transport (GO:0015824)3.98264596
27regulation of synapse structural plasticity (GO:0051823)3.90901492
28glutamate receptor signaling pathway (GO:0007215)3.90619113
29cellular potassium ion homeostasis (GO:0030007)3.83799583
30synaptic transmission, glutamatergic (GO:0035249)3.73705005
31activation of protein kinase A activity (GO:0034199)3.72063451
32dendritic spine morphogenesis (GO:0060997)3.70740407
33neuron-neuron synaptic transmission (GO:0007270)3.64908110
34neurotransmitter transport (GO:0006836)3.63897896
35positive regulation of dendritic spine morphogenesis (GO:0061003)3.63770215
36gamma-aminobutyric acid transport (GO:0015812)3.61666805
37neuromuscular process controlling posture (GO:0050884)3.61288166
38synaptic vesicle endocytosis (GO:0048488)3.59697965
39sodium ion export (GO:0071436)3.58108816
40vesicle transport along microtubule (GO:0047496)3.57247291
41long-term memory (GO:0007616)3.54530619
42neuron recognition (GO:0008038)3.52402424
43amino acid import (GO:0043090)3.51726958
44cell communication involved in cardiac conduction (GO:0086065)3.43961742
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43945540
46positive regulation of synapse maturation (GO:0090129)3.42971496
47regulation of synaptic plasticity (GO:0048167)3.42853804
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38903579
49cerebellar Purkinje cell differentiation (GO:0021702)3.38509256
50regulation of clathrin-mediated endocytosis (GO:2000369)3.36871684
51regulation of neurotransmitter levels (GO:0001505)3.36672557
52regulation of postsynaptic membrane potential (GO:0060078)3.35906951
53positive regulation of membrane potential (GO:0045838)3.31834527
54cellular sodium ion homeostasis (GO:0006883)3.31603876
55innervation (GO:0060384)3.31429002
56regulation of vesicle fusion (GO:0031338)3.30584091
57regulation of neurotransmitter secretion (GO:0046928)3.30374131
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.30023270
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28634861
60long-term synaptic potentiation (GO:0060291)3.28332021
61axonal fasciculation (GO:0007413)3.27792181
62neuromuscular process controlling balance (GO:0050885)3.25805734
63neurotransmitter-gated ion channel clustering (GO:0072578)3.25637072
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25578434
65potassium ion import (GO:0010107)3.25483836
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25479522
67regulation of dendritic spine morphogenesis (GO:0061001)3.23023125
68cell communication by electrical coupling (GO:0010644)3.20862220
69regulation of voltage-gated calcium channel activity (GO:1901385)3.17151007
70regulation of ARF protein signal transduction (GO:0032012)3.13986440
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13927684
72organelle transport along microtubule (GO:0072384)3.09725516
73behavioral response to cocaine (GO:0048148)3.09168472
74response to auditory stimulus (GO:0010996)3.08823066
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.08637027
76intraspecies interaction between organisms (GO:0051703)3.08478705
77social behavior (GO:0035176)3.08478705
78positive regulation of neurotransmitter secretion (GO:0001956)3.07679341
79establishment of nucleus localization (GO:0040023)3.06919474
80positive regulation of dendritic spine development (GO:0060999)3.06733122
81neuronal ion channel clustering (GO:0045161)3.05745839
82regulation of neurotransmitter transport (GO:0051588)3.03802015
83dendrite morphogenesis (GO:0048813)3.03389361
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.02554105
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02193202
86establishment of synaptic vesicle localization (GO:0097480)3.02149150
87synaptic vesicle transport (GO:0048489)3.02149150
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02028295
89regulation of dendritic spine development (GO:0060998)3.00746938
90positive regulation of neurotransmitter transport (GO:0051590)2.99966070
91negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99397866
92response to pheromone (GO:0019236)2.99139469
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97042632
94dopamine biosynthetic process (GO:0042416)2.94969561
95glycine transport (GO:0015816)2.94511027
96central nervous system myelination (GO:0022010)2.93634293
97axon ensheathment in central nervous system (GO:0032291)2.93634293
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93385081
99presynaptic membrane organization (GO:0097090)2.93029799
100auditory behavior (GO:0031223)2.91329040
101membrane depolarization during action potential (GO:0086010)2.91063393
102positive regulation of synaptic transmission (GO:0050806)2.90507719
103potassium ion homeostasis (GO:0055075)2.90402559
104transmission of nerve impulse (GO:0019226)2.89288446
105cell migration in hindbrain (GO:0021535)2.88898114
106regulation of synaptic transmission (GO:0050804)2.88841553
107membrane depolarization (GO:0051899)2.87933967
108neuromuscular process (GO:0050905)2.87915758
109presynaptic membrane assembly (GO:0097105)2.87346500
110mating behavior (GO:0007617)2.85808705
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84801859
112synaptic transmission (GO:0007268)2.83710903
113response to histamine (GO:0034776)2.83123493
114positive regulation of vesicle fusion (GO:0031340)2.82641403
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82052833
116negative regulation of dendrite morphogenesis (GO:0050774)2.81834839
117response to insecticide (GO:0017085)2.81234044
118neurofilament cytoskeleton organization (GO:0060052)2.80794749
119postsynaptic membrane organization (GO:0001941)2.80779416
120behavioral fear response (GO:0001662)2.79987649
121behavioral defense response (GO:0002209)2.79987649
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79673874
123cerebellar Purkinje cell layer development (GO:0021680)2.79647006
124clathrin coat assembly (GO:0048268)2.78978026
125prepulse inhibition (GO:0060134)2.77443757
126neuromuscular synaptic transmission (GO:0007274)2.76997955
127regulation of cAMP-dependent protein kinase activity (GO:2000479)2.76229219
128adult walking behavior (GO:0007628)2.76078035
129establishment of mitochondrion localization (GO:0051654)2.74919375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62657998
2GBX2_23144817_ChIP-Seq_PC3_Human3.26229019
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98410605
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95075735
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94550876
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58589462
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58589462
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55525976
9REST_21632747_ChIP-Seq_MESCs_Mouse2.50141959
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43936747
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43244497
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41657134
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40333734
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.36791736
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35309975
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.24761246
17DROSHA_22980978_ChIP-Seq_HELA_Human2.24044138
18AR_21572438_ChIP-Seq_LNCaP_Human2.19128191
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13186862
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11711819
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08865962
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.08349766
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05594912
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.03738601
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.02176694
26* REST_18959480_ChIP-ChIP_MESCs_Mouse2.01528464
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97765979
28TAF15_26573619_Chip-Seq_HEK293_Human1.93092173
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90172266
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88120056
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84044338
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75067435
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72540802
34ZNF274_21170338_ChIP-Seq_K562_Hela1.71843915
35SMAD4_21799915_ChIP-Seq_A2780_Human1.71616378
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.67988442
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66522328
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63274752
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54222994
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.44672918
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43670663
42* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43117651
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.39689589
44P300_19829295_ChIP-Seq_ESCs_Human1.39468432
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37850040
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36952389
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36573756
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35838211
49AR_25329375_ChIP-Seq_VCAP_Human1.35519306
50* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35456885
51* EP300_21415370_ChIP-Seq_HL-1_Mouse1.34937726
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32015492
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30487203
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.27955039
55STAT3_23295773_ChIP-Seq_U87_Human1.25164935
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.24557407
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23884085
58IGF1R_20145208_ChIP-Seq_DFB_Human1.22869248
59* AR_19668381_ChIP-Seq_PC3_Human1.22637235
60LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22017313
61TP53_16413492_ChIP-PET_HCT116_Human1.21989939
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.20411469
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20174159
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20024927
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19637724
66* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19595498
67CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19053511
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17351677
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17197438
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16522864
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16320206
72* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15331295
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.15015266
74* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14646230
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14008525
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.13869883
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13804194
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13788688
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13196078
80FUS_26573619_Chip-Seq_HEK293_Human1.13001685
81KDM2B_26808549_Chip-Seq_K562_Human1.12907525
82RXR_22108803_ChIP-Seq_LS180_Human1.12820953
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12760924
84* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11629489
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11269666
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.10771886
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10607734
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10337612
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10337612
90ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09424158
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09114601
92AHR_22903824_ChIP-Seq_MCF-7_Human1.09113015
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08312921
94TP53_18474530_ChIP-ChIP_U2OS_Human1.07985896
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.06524604
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04266262
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03977762
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02879973
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02775960
100TCF4_23295773_ChIP-Seq_U87_Human1.01425481
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00316360
102WT1_19549856_ChIP-ChIP_CCG9911_Human0.99892937
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99799536
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99799536
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99450399
106RING1B_27294783_Chip-Seq_NPCs_Mouse0.99225289
107STAT3_18555785_ChIP-Seq_MESCs_Mouse0.98847665
108BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98527315
109* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97847014
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.97344658
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.97019051
112RUNX2_22187159_ChIP-Seq_PCA_Human0.96830732
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.96716291
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.96490761
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96380633
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.96135643
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.95894618
118RNF2_27304074_Chip-Seq_NSC_Mouse0.94869099
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94687208
120BCAT_22108803_ChIP-Seq_LS180_Human0.93294898
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.92770602
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92023059
123JUN_21703547_ChIP-Seq_K562_Human0.91900638
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91431789
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84896538
126* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84895043
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82241195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.80470821
2MP0003880_abnormal_central_pattern5.10859963
3MP0003635_abnormal_synaptic_transmissio4.22747541
4MP0004270_analgesia3.76656957
5MP0001968_abnormal_touch/_nociception3.38594520
6MP0002063_abnormal_learning/memory/cond3.32100306
7MP0009745_abnormal_behavioral_response3.31121454
8MP0002064_seizures3.09169330
9MP0009046_muscle_twitch3.03327106
10MP0002736_abnormal_nociception_after2.76818759
11MP0002572_abnormal_emotion/affect_behav2.66188272
12MP0002734_abnormal_mechanical_nocicepti2.61718795
13MP0005423_abnormal_somatic_nervous2.45680343
14MP0002822_catalepsy2.43843962
15MP0002735_abnormal_chemical_nociception2.39963992
16MP0002272_abnormal_nervous_system2.37182409
17MP0001501_abnormal_sleep_pattern2.30608832
18MP0001486_abnormal_startle_reflex2.29607666
19MP0001440_abnormal_grooming_behavior2.25594745
20MP0006276_abnormal_autonomic_nervous2.15468421
21MP0002733_abnormal_thermal_nociception2.14892347
22MP0003329_amyloid_beta_deposits2.03548442
23MP0003122_maternal_imprinting2.03468938
24MP0001970_abnormal_pain_threshold2.00541317
25* MP0002067_abnormal_sensory_capabilities1.97309932
26MP0004858_abnormal_nervous_system1.89337669
27MP0002909_abnormal_adrenal_gland1.88961960
28MP0009780_abnormal_chondrocyte_physiolo1.88637353
29MP0002184_abnormal_innervation1.86200427
30MP0004811_abnormal_neuron_physiology1.84368656
31MP0004924_abnormal_behavior1.79544267
32MP0005386_behavior/neurological_phenoty1.79544267
33MP0002557_abnormal_social/conspecific_i1.71204203
34MP0008569_lethality_at_weaning1.66382814
35MP0010234_abnormal_vibrissa_follicle1.64654247
36MP0005645_abnormal_hypothalamus_physiol1.61181068
37MP0003879_abnormal_hair_cell1.61082664
38* MP0000778_abnormal_nervous_system1.60532849
39MP0000955_abnormal_spinal_cord1.52733884
40MP0003890_abnormal_embryonic-extraembry1.52447291
41MP0005409_darkened_coat_color1.50340695
42MP0001984_abnormal_olfaction1.48179160
43MP0003787_abnormal_imprinting1.46292185
44MP0008877_abnormal_DNA_methylation1.44845913
45MP0003183_abnormal_peptide_metabolism1.43082058
46* MP0002066_abnormal_motor_capabilities/c1.37373479
47MP0000579_abnormal_nail_morphology1.37010300
48MP0000751_myopathy1.32967414
49MP0003633_abnormal_nervous_system1.32728497
50MP0005646_abnormal_pituitary_gland1.29803932
51* MP0002882_abnormal_neuron_morphology1.28311176
52MP0008260_abnormal_autophagy1.27971999
53MP0001529_abnormal_vocalization1.25226701
54MP0000569_abnormal_digit_pigmentation1.18022919
55MP0004885_abnormal_endolymph1.17058622
56MP0004142_abnormal_muscle_tone1.15293553
57MP0004145_abnormal_muscle_electrophysio1.13322604
58MP0003123_paternal_imprinting1.12070336
59MP0003631_nervous_system_phenotype1.10837470
60MP0008961_abnormal_basal_metabolism1.10181774
61MP0001502_abnormal_circadian_rhythm1.09659535
62MP0000566_synostosis1.04951564
63MP0001905_abnormal_dopamine_level1.02137984
64* MP0002152_abnormal_brain_morphology1.01048904
65MP0002089_abnormal_postnatal_growth/wei1.00682743
66MP0005187_abnormal_penis_morphology0.98800390
67MP0008874_decreased_physiological_sensi0.95888642
68MP0000604_amyloidosis0.95192143
69MP0002837_dystrophic_cardiac_calcinosis0.93862430
70MP0001177_atelectasis0.93518157
71MP0004484_altered_response_of0.86140392
72MP0004510_myositis0.85806806
73MP0003121_genomic_imprinting0.85740214
74MP0003075_altered_response_to0.84913229
75MP0002069_abnormal_eating/drinking_beha0.83673245
76MP0010386_abnormal_urinary_bladder0.83573112
77MP0005167_abnormal_blood-brain_barrier0.82189090
78MP0008872_abnormal_physiological_respon0.81981793
79MP0003283_abnormal_digestive_organ0.81104898
80MP0004742_abnormal_vestibular_system0.78966908
81MP0001299_abnormal_eye_distance/0.78937528
82MP0005535_abnormal_body_temperature0.78569986
83MP0004215_abnormal_myocardial_fiber0.76615933
84MP0000749_muscle_degeneration0.75322201
85MP0003632_abnormal_nervous_system0.75043329
86MP0004233_abnormal_muscle_weight0.73948703
87MP0002229_neurodegeneration0.73233494
88MP0008057_abnormal_DNA_replication0.70948901
89MP0005248_abnormal_Harderian_gland0.69923141
90MP0000747_muscle_weakness0.69885849
91MP0000013_abnormal_adipose_tissue0.69763149
92MP0004085_abnormal_heartbeat0.68523902
93MP0001346_abnormal_lacrimal_gland0.68106957
94MP0001348_abnormal_lacrimal_gland0.67436681
95MP0003634_abnormal_glial_cell0.66581257
96MP0003646_muscle_fatigue0.66290347
97MP0003690_abnormal_glial_cell0.64383980
98MP0004130_abnormal_muscle_cell0.64057591
99MP0005499_abnormal_olfactory_system0.62670207
100MP0005394_taste/olfaction_phenotype0.62670207
101MP0001485_abnormal_pinna_reflex0.62416849
102MP0005623_abnormal_meninges_morphology0.62113723
103MP0002133_abnormal_respiratory_system0.60532918
104MP0005388_respiratory_system_phenotype0.60532918
105MP0001188_hyperpigmentation0.60270448
106MP0001963_abnormal_hearing_physiology0.59990959
107* MP0010770_preweaning_lethality0.57373439
108* MP0002082_postnatal_lethality0.57373439
109MP0000537_abnormal_urethra_morphology0.57361433
110MP0001664_abnormal_digestion0.56696263
111MP0002332_abnormal_exercise_endurance0.56258300
112MP0002081_perinatal_lethality0.55677408
113MP0001943_abnormal_respiration0.54757520
114MP0002090_abnormal_vision0.53966408
115MP0005166_decreased_susceptibility_to0.53665150
116MP0002752_abnormal_somatic_nervous0.53432088
117MP0000920_abnormal_myelination0.52796740
118MP0003137_abnormal_impulse_conducting0.50694299
119MP0000631_abnormal_neuroendocrine_gland0.50220765
120* MP0003861_abnormal_nervous_system0.48578022
121* MP0010769_abnormal_survival0.46325754

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.84347269
2Myokymia (HP:0002411)6.32602292
3Focal seizures (HP:0007359)5.89114152
4Visual hallucinations (HP:0002367)5.78401915
5Atonic seizures (HP:0010819)4.57085051
6Absence seizures (HP:0002121)4.51263974
7Epileptic encephalopathy (HP:0200134)4.31441970
8Febrile seizures (HP:0002373)4.24417485
9Progressive cerebellar ataxia (HP:0002073)4.20878116
10Generalized tonic-clonic seizures (HP:0002069)4.07232058
11Dialeptic seizures (HP:0011146)4.01138706
12Action tremor (HP:0002345)3.85189958
13Supranuclear gaze palsy (HP:0000605)3.66354950
14Depression (HP:0000716)3.30844149
15Impaired vibration sensation in the lower limbs (HP:0002166)3.28791648
16Ankle clonus (HP:0011448)3.26853545
17Poor eye contact (HP:0000817)3.24979427
18Papilledema (HP:0001085)3.12955185
19Abnormal eating behavior (HP:0100738)3.12480706
20Mutism (HP:0002300)3.12075582
21Broad-based gait (HP:0002136)3.07226362
22Urinary bladder sphincter dysfunction (HP:0002839)3.03662039
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.03411072
24Degeneration of the lateral corticospinal tracts (HP:0002314)3.03411072
25Impaired social interactions (HP:0000735)3.01131966
26Abnormal social behavior (HP:0012433)3.01131966
27Dysdiadochokinesis (HP:0002075)2.98759623
28Progressive inability to walk (HP:0002505)2.97889527
29Urinary urgency (HP:0000012)2.95240668
30Truncal ataxia (HP:0002078)2.90558412
31Postural instability (HP:0002172)2.87765505
32Genetic anticipation (HP:0003743)2.86407995
33Termporal pattern (HP:0011008)2.83634840
34Insidious onset (HP:0003587)2.83634840
35Dysmetria (HP:0001310)2.81512965
36Gaze-evoked nystagmus (HP:0000640)2.76337226
37Amblyopia (HP:0000646)2.73396055
38Anxiety (HP:0000739)2.68180161
39Abnormality of the lower motor neuron (HP:0002366)2.61816124
40Drooling (HP:0002307)2.60630163
41Excessive salivation (HP:0003781)2.60630163
42Morphological abnormality of the pyramidal tract (HP:0002062)2.57667557
43Failure to thrive in infancy (HP:0001531)2.54671700
44Hyperventilation (HP:0002883)2.54468589
45Ventricular fibrillation (HP:0001663)2.50924770
46Fetal akinesia sequence (HP:0001989)2.50215985
47Polyphagia (HP:0002591)2.47962131
48Papillary thyroid carcinoma (HP:0002895)2.46496868
49Limb dystonia (HP:0002451)2.45146921
50Torticollis (HP:0000473)2.42421007
51Bradykinesia (HP:0002067)2.41738995
52Impaired smooth pursuit (HP:0007772)2.40030585
53Pheochromocytoma (HP:0002666)2.37718124
54Scanning speech (HP:0002168)2.35238989
55Status epilepticus (HP:0002133)2.35105536
56Spastic gait (HP:0002064)2.31959985
57Cerebral inclusion bodies (HP:0100314)2.31227935
58Tetraplegia (HP:0002445)2.30714419
59Difficulty running (HP:0009046)2.30027153
60Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.29139877
61Generalized myoclonic seizures (HP:0002123)2.27676709
62Epileptiform EEG discharges (HP:0011182)2.27234045
63Dysmetric saccades (HP:0000641)2.25727433
64Clonus (HP:0002169)2.25087133
65Hemiparesis (HP:0001269)2.21654280
66Diplopia (HP:0000651)2.20560564
67Abnormality of binocular vision (HP:0011514)2.20560564
68Aplasia involving bones of the extremities (HP:0009825)2.18722570
69Aplasia involving bones of the upper limbs (HP:0009823)2.18722570
70Aplasia of the phalanges of the hand (HP:0009802)2.18722570
71EEG with generalized epileptiform discharges (HP:0011198)2.18618698
72Focal dystonia (HP:0004373)2.18402063
73Agitation (HP:0000713)2.18330277
74Stereotypic behavior (HP:0000733)2.18062669
75Hemiplegia (HP:0002301)2.17242043
76Intention tremor (HP:0002080)2.17195190
77Impaired vibratory sensation (HP:0002495)2.14456710
78Abnormality of ocular smooth pursuit (HP:0000617)2.14160887
79Sleep apnea (HP:0010535)2.14070319
80Absent speech (HP:0001344)2.13336511
81Inability to walk (HP:0002540)2.09662484
82Aqueductal stenosis (HP:0002410)2.07828016
83Bundle branch block (HP:0011710)2.07825331
84Hypsarrhythmia (HP:0002521)2.07509863
85Inappropriate behavior (HP:0000719)2.06084908
86Hyporeflexia of lower limbs (HP:0002600)2.05616724
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05295090
88Delusions (HP:0000746)2.04204497
89Lower limb asymmetry (HP:0100559)2.03054568
90Megalencephaly (HP:0001355)2.01743379
91Lower limb muscle weakness (HP:0007340)2.01653522
92Apathy (HP:0000741)2.01562536
93Split foot (HP:0001839)2.00813210
94Neuroendocrine neoplasm (HP:0100634)2.00730467
95Shoulder girdle muscle weakness (HP:0003547)2.00066608
96Rapidly progressive (HP:0003678)1.99173446
97Hypoventilation (HP:0002791)1.98844246
98Thickened helices (HP:0000391)1.98556513
99Decreased motor nerve conduction velocity (HP:0003431)1.98033898
100Amyotrophic lateral sclerosis (HP:0007354)1.96055296
101Neoplasm of the peripheral nervous system (HP:0100007)1.96030063
102Gait ataxia (HP:0002066)1.93601187
103Pointed chin (HP:0000307)1.92206454
104Lower limb amyotrophy (HP:0007210)1.91996187
105Craniofacial dystonia (HP:0012179)1.91596722
106Paraplegia (HP:0010550)1.91465676
107Hammertoe (HP:0001765)1.91273101
108Peripheral hypomyelination (HP:0007182)1.89609163
109Foot dorsiflexor weakness (HP:0009027)1.89042162
110Neurofibrillary tangles (HP:0002185)1.88100274
111Psychosis (HP:0000709)1.87098996
112Ankyloglossia (HP:0010296)1.86663647
113Blue irides (HP:0000635)1.86527373
114Abnormality of the corticospinal tract (HP:0002492)1.84588653
115Incomplete penetrance (HP:0003829)1.84535035
116Spastic paraplegia (HP:0001258)1.84512279
117Rigidity (HP:0002063)1.83815894
118Agnosia (HP:0010524)1.82113718
119Intellectual disability, profound (HP:0002187)1.82084939
120Spastic tetraparesis (HP:0001285)1.80886439
121Distal sensory impairment (HP:0002936)1.79982796
122Neuronal loss in central nervous system (HP:0002529)1.79908391
123Slow saccadic eye movements (HP:0000514)1.78998558
124Abnormality of the foot musculature (HP:0001436)1.78765750
125Diminished motivation (HP:0000745)1.78465853
126Resting tremor (HP:0002322)1.76975847
127Abnormality of saccadic eye movements (HP:0000570)1.76466587
128Abnormality of salivation (HP:0100755)1.75859050
129Akinesia (HP:0002304)1.75606631
130Dysphonia (HP:0001618)1.75538051
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74990570
132Subacute progressive viral hepatitis (HP:0006572)1.73267938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.72618956
2NTRK34.51962180
3MAP3K43.49329319
4EPHA43.31244269
5MINK13.19484794
6KSR22.86065725
7MARK12.69644509
8MAP2K72.68613722
9PAK62.32391153
10RIPK42.26595156
11* MAP2K42.13968366
12KSR12.10454454
13LATS21.96347760
14DAPK21.94764821
15NTRK21.91617116
16CAMKK11.73398138
17MAP3K131.64150078
18PRKD31.59953917
19NTRK11.59786260
20ARAF1.56965492
21CDK191.49380439
22PLK21.47007373
23CDK51.43261324
24STK381.33845146
25MAP3K21.26734384
26GRK51.26387025
27DAPK11.22845341
28TAOK11.22636999
29RET1.22405037
30TYRO31.17435785
31PNCK1.14154043
32MAPK131.11784917
33TNIK1.11313207
34RAF11.08588153
35PAK31.06701335
36CASK1.05314609
37OBSCN1.04640478
38PRKCG1.00032018
39SIK20.94472533
40FER0.94352609
41FES0.94300535
42CDK180.93197087
43CDK140.92722311
44PHKG10.91366239
45PHKG20.91366239
46MAP3K60.89840358
47CDK150.89012264
48STK110.88370729
49CAMK2A0.88369105
50NEK10.86673811
51LMTK20.85911342
52ALK0.85879305
53WNK30.84803633
54UHMK10.84257243
55CAMKK20.79313910
56CDK11A0.75983028
57STK390.74176467
58CSNK1G20.74156014
59CAMK10.74051969
60PRPF4B0.73272318
61CAMK40.72807635
62PRKCH0.72146959
63SCYL20.71673166
64SIK30.71066850
65PDK10.69340466
66YES10.69295311
67DYRK20.68390377
68BCR0.67095039
69RIPK10.66964324
70TSSK60.66889634
71AKT30.65504326
72WNK10.65013664
73PTK2B0.64574650
74PDGFRA0.63744139
75PDPK10.62631122
76MAP2K10.61874284
77SGK2230.61727755
78SGK4940.61727755
79SGK20.60590961
80FGFR20.60533814
81PINK10.58699924
82BMPR20.57909704
83SGK30.57311443
84LIMK10.57099547
85* SGK10.54642433
86BRAF0.54197815
87DYRK1B0.52769268
88TNK20.52580679
89MAPK120.52334368
90NEK60.52216852
91CAMK2B0.51744500
92DMPK0.51731274
93ERBB30.51132362
94MAPK100.49409783
95MAP3K70.46834770
96CAMK1D0.46725771
97RPS6KA30.45307760
98CSNK1G10.44820454
99FYN0.44396322
100* MAP3K10.44289788
101DYRK1A0.43836236
102PRKCZ0.43803066
103CSNK1A1L0.42668537
104NME10.42133669
105ROCK20.41699552
106MAP2K30.41415365
107BMX0.40469884
108MOS0.40327238
109MAPKAPK50.39589797
110PRKG10.39279112
111RPS6KB10.38789066
112* MAP3K120.38698019
113BRD40.37283901
114MARK20.37129289
115CAMK2G0.36397833
116FGR0.35953227
117OXSR10.35159099
118CAMK1G0.34194207
119PRKCE0.33587185
120CDC42BPA0.33264767

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.39072766
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27949703
3Long-term potentiation_Homo sapiens_hsa047202.61907778
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41495053
5Olfactory transduction_Homo sapiens_hsa047402.40759343
6GABAergic synapse_Homo sapiens_hsa047272.40336685
7Circadian entrainment_Homo sapiens_hsa047132.37912105
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28638412
9Glutamatergic synapse_Homo sapiens_hsa047242.28078229
10Amphetamine addiction_Homo sapiens_hsa050312.17447243
11Morphine addiction_Homo sapiens_hsa050322.12905370
12Dopaminergic synapse_Homo sapiens_hsa047282.07018850
13Salivary secretion_Homo sapiens_hsa049701.92384922
14Gastric acid secretion_Homo sapiens_hsa049711.81138768
15Long-term depression_Homo sapiens_hsa047301.75275119
16Insulin secretion_Homo sapiens_hsa049111.75018891
17Cholinergic synapse_Homo sapiens_hsa047251.72139960
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62877979
19Renin secretion_Homo sapiens_hsa049241.61019470
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60877146
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60465676
22Oxytocin signaling pathway_Homo sapiens_hsa049211.60383825
23Serotonergic synapse_Homo sapiens_hsa047261.53546591
24* GnRH signaling pathway_Homo sapiens_hsa049121.53251703
25Cocaine addiction_Homo sapiens_hsa050301.47413115
26Calcium signaling pathway_Homo sapiens_hsa040201.39856572
27Taste transduction_Homo sapiens_hsa047421.38634411
28Gap junction_Homo sapiens_hsa045401.38344520
29Glioma_Homo sapiens_hsa052141.35715380
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35636929
31Collecting duct acid secretion_Homo sapiens_hsa049661.34183254
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26885800
33Estrogen signaling pathway_Homo sapiens_hsa049151.23140095
34Nitrogen metabolism_Homo sapiens_hsa009101.16543706
35Type II diabetes mellitus_Homo sapiens_hsa049301.15487309
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13859619
37cAMP signaling pathway_Homo sapiens_hsa040241.13182132
38Dorso-ventral axis formation_Homo sapiens_hsa043201.12835513
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11683640
40* ErbB signaling pathway_Homo sapiens_hsa040121.10964008
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09131840
42Axon guidance_Homo sapiens_hsa043601.07623168
43Melanogenesis_Homo sapiens_hsa049161.05274730
44Oocyte meiosis_Homo sapiens_hsa041141.00005693
45VEGF signaling pathway_Homo sapiens_hsa043700.93668901
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88471621
47Vibrio cholerae infection_Homo sapiens_hsa051100.88372850
48* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86661463
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.86413036
50Choline metabolism in cancer_Homo sapiens_hsa052310.85859060
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.85224444
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.81774738
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81127247
54Cardiac muscle contraction_Homo sapiens_hsa042600.79542809
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76734456
56Dilated cardiomyopathy_Homo sapiens_hsa054140.76577102
57* MAPK signaling pathway_Homo sapiens_hsa040100.75718061
58Fatty acid biosynthesis_Homo sapiens_hsa000610.74698039
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73928390
60Tight junction_Homo sapiens_hsa045300.72922603
61mTOR signaling pathway_Homo sapiens_hsa041500.72848476
62Thyroid hormone synthesis_Homo sapiens_hsa049180.70356412
63Adherens junction_Homo sapiens_hsa045200.69237336
64Hippo signaling pathway_Homo sapiens_hsa043900.68001919
65Pancreatic secretion_Homo sapiens_hsa049720.67265849
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.65478088
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63760868
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63356007
69Endometrial cancer_Homo sapiens_hsa052130.63194704
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62745882
71Ras signaling pathway_Homo sapiens_hsa040140.61838036
72Glucagon signaling pathway_Homo sapiens_hsa049220.60715421
73Alcoholism_Homo sapiens_hsa050340.60620628
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59881795
75Regulation of autophagy_Homo sapiens_hsa041400.59391535
76Vitamin B6 metabolism_Homo sapiens_hsa007500.59251149
77Insulin signaling pathway_Homo sapiens_hsa049100.58455539
78Non-small cell lung cancer_Homo sapiens_hsa052230.57725606
79Endocytosis_Homo sapiens_hsa041440.57505165
80Rap1 signaling pathway_Homo sapiens_hsa040150.57407644
81Renal cell carcinoma_Homo sapiens_hsa052110.56767910
82Prion diseases_Homo sapiens_hsa050200.56306093
83Type I diabetes mellitus_Homo sapiens_hsa049400.55575951
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55072024
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53178412
86Inositol phosphate metabolism_Homo sapiens_hsa005620.52986637
87* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52892420
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51803156
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51429638
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49167745
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49161553
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48751223
93Prolactin signaling pathway_Homo sapiens_hsa049170.47790922
94Bile secretion_Homo sapiens_hsa049760.46794596
95FoxO signaling pathway_Homo sapiens_hsa040680.46629014
96Amoebiasis_Homo sapiens_hsa051460.45202409
97Wnt signaling pathway_Homo sapiens_hsa043100.44850001
98Salmonella infection_Homo sapiens_hsa051320.44257080
99Proteoglycans in cancer_Homo sapiens_hsa052050.43762994
100African trypanosomiasis_Homo sapiens_hsa051430.42812026
101AMPK signaling pathway_Homo sapiens_hsa041520.42797207
102Phototransduction_Homo sapiens_hsa047440.41824481
103Colorectal cancer_Homo sapiens_hsa052100.41267680
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40107898
105Chemokine signaling pathway_Homo sapiens_hsa040620.40010551
106Circadian rhythm_Homo sapiens_hsa047100.37867764
107Arginine biosynthesis_Homo sapiens_hsa002200.37710241
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35158574
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35078468
110Ovarian steroidogenesis_Homo sapiens_hsa049130.34790918
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.33826803
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33547363
113Platelet activation_Homo sapiens_hsa046110.33028841
114* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33011927

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