ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	6.74616613
2	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.20791133
3	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.20791133
4	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	6.11259488
5	UMP biosynthetic process (GO:0006222)	6.11259488
6	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	6.11259488
7	UMP metabolic process (GO:0046049)	6.11259488
8	pyrimidine nucleoside salvage (GO:0043097)	5.95940789
9	pyrimidine-containing compound salvage (GO:0008655)	5.95940789
10	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	5.08114527
11	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	4.71750015
12	piRNA metabolic process (GO:0034587)	4.54874596
13	nucleotide salvage (GO:0043173)	4.45002517
14	nucleoside salvage (GO:0043174)	4.23084475
15	platelet dense granule organization (GO:0060155)	4.15612862
16	adaptation of signaling pathway (GO:0023058)	4.13229364
17	snRNA transcription (GO:0009301)	4.10474077
18	behavioral response to nicotine (GO:0035095)	4.04346672
19	axonemal dynein complex assembly (GO:0070286)	3.93962286
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.90551112
21	cilium or flagellum-dependent cell motility (GO:0001539)	3.86068425
22	seminiferous tubule development (GO:0072520)	3.76087805
23	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.61894857
24	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.59722451
25	retinal cone cell development (GO:0046549)	3.57984775
26	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.56434301
27	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.49838072
28	detection of light stimulus involved in sensory perception (GO:0050962)	3.31367221
29	detection of light stimulus involved in visual perception (GO:0050908)	3.31367221
30	pyrimidine nucleotide catabolic process (GO:0006244)	3.28544502
31	galactose metabolic process (GO:0006012)	3.25037195
32	tongue development (GO:0043586)	3.23532323
33	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.17156113
34	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.11885414
35	establishment of protein localization to Golgi (GO:0072600)	3.10631721
36	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.06409823
37	DNA methylation involved in gamete generation (GO:0043046)	3.03630561
38	negative regulation of telomere maintenance (GO:0032205)	3.01052961
39	transmission of nerve impulse (GO:0019226)	3.00628400
40	brain morphogenesis (GO:0048854)	2.99037221
41	positive regulation of growth hormone secretion (GO:0060124)	2.98921502
42	positive regulation of synapse assembly (GO:0051965)	2.98535361
43	parturition (GO:0007567)	2.96369178
44	sulfation (GO:0051923)	2.95005866
45	protein K48-linked deubiquitination (GO:0071108)	2.93132740
46	photoreceptor cell maintenance (GO:0045494)	2.91144769
47	presynaptic membrane assembly (GO:0097105)	2.90653563
48	resolution of meiotic recombination intermediates (GO:0000712)	2.88877217
49	microtubule severing (GO:0051013)	2.88828344
50	indolalkylamine metabolic process (GO:0006586)	2.88230976
51	neural tube formation (GO:0001841)	2.87273863
52	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.86680014
53	CTP metabolic process (GO:0046036)	2.84827418
54	CTP biosynthetic process (GO:0006241)	2.84827418
55	serotonin receptor signaling pathway (GO:0007210)	2.83132281
56	pyrimidine-containing compound catabolic process (GO:0072529)	2.83106327
57	anterograde synaptic vesicle transport (GO:0048490)	2.83038961
58	replication fork processing (GO:0031297)	2.80678720
59	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.79044496
60	positive regulation of vascular permeability (GO:0043117)	2.77256396
61	protein prenylation (GO:0018342)	2.76892457
62	prenylation (GO:0097354)	2.76892457
63	DNA double-strand break processing (GO:0000729)	2.75325977
64	pyrimidine nucleotide metabolic process (GO:0006220)	2.73280846
65	synaptic transmission, cholinergic (GO:0007271)	2.70958987
66	regulation of B cell receptor signaling pathway (GO:0050855)	2.70018317
67	central nervous system projection neuron axonogenesis (GO:0021952)	2.69352547
68	fucose catabolic process (GO:0019317)	2.69180245
69	L-fucose metabolic process (GO:0042354)	2.69180245
70	L-fucose catabolic process (GO:0042355)	2.69180245
71	negative regulation of neurological system process (GO:0031645)	2.69168546
72	pyrimidine nucleoside catabolic process (GO:0046135)	2.68804316
73	negative regulation of membrane potential (GO:0045837)	2.65767702
74	central nervous system neuron axonogenesis (GO:0021955)	2.62650438
75	regulation of telomere maintenance (GO:0032204)	2.62315874
76	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.61633212
77	tachykinin receptor signaling pathway (GO:0007217)	2.60756901
78	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	2.60054366
79	indole-containing compound catabolic process (GO:0042436)	2.59332729
80	indolalkylamine catabolic process (GO:0046218)	2.59332729
81	tryptophan catabolic process (GO:0006569)	2.59332729
82	protein targeting to Golgi (GO:0000042)	2.58896566
83	protein-cofactor linkage (GO:0018065)	2.58540038
84	proline transport (GO:0015824)	2.54645913
85	pyrimidine nucleoside biosynthetic process (GO:0046134)	2.53744792
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.52512777
87	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.52512777
88	pyrimidine nucleobase metabolic process (GO:0006206)	2.52265328
89	tRNA processing (GO:0008033)	2.51353563
90	righting reflex (GO:0060013)	2.49602418
91	response to superoxide (GO:0000303)	2.49442196
92	male meiosis I (GO:0007141)	2.48969636
93	presynaptic membrane organization (GO:0097090)	2.48605125
94	regulation of timing of cell differentiation (GO:0048505)	2.48029248
95	interferon-gamma production (GO:0032609)	2.47247753
96	DNA-dependent DNA replication (GO:0006261)	2.47136691
97	protein K63-linked deubiquitination (GO:0070536)	2.43928528
98	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.43920859
99	epithelial cilium movement (GO:0003351)	2.43596784
100	phenylpropanoid metabolic process (GO:0009698)	2.42430657

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.07326400
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.58783375
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.56859158
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.45954514
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02769116
6	VDR_22108803_ChIP-Seq_LS180_Human	2.65779533
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.57464838
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52248894
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34936919
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32961817
11	EWS_26573619_Chip-Seq_HEK293_Human	2.26038685
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.23719717
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.19804275
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.18137620
15	P300_19829295_ChIP-Seq_ESCs_Human	2.11256440
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.08169731
17	IRF1_19129219_ChIP-ChIP_H3396_Human	2.05233802
18	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.94203636
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88728939
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87688640
21	FUS_26573619_Chip-Seq_HEK293_Human	1.85708461
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.83909486
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83706516
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.80938788
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.80039628
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.79451524
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75280191
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.74812884
29	AR_25329375_ChIP-Seq_VCAP_Human	1.74417815
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.72766397
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.71505674
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.71505674
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70988446
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.68343145
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58001205
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.57525556
37	AR_21572438_ChIP-Seq_LNCaP_Human	1.54761903
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.54335782
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53432322
40	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.48926336
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46725714
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46725714
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45541889
44	CDX2_22108803_ChIP-Seq_LS180_Human	1.43282238
45	TCF4_23295773_ChIP-Seq_U87_Human	1.42733615
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42240370
47	STAT3_23295773_ChIP-Seq_U87_Human	1.41495726
48	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.38377055
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.37195504
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.37122517
51	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.34845902
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34479362
53	VDR_23849224_ChIP-Seq_CD4+_Human	1.32685944
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32625629
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31737828
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.28268074
57	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.28127701
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27980553
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27696592
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27680957
61	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.27533687
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27117499
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.26050480
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25700470
65	NCOR_22424771_ChIP-Seq_293T_Human	1.25010287
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23962162
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23489511
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23459751
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22416120
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22416120
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20452738
72	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20135341
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20005992
74	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19986528
75	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18454020
76	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18087347
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18031109
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16219521
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15435173
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15435173
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13313011
82	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.08793518
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06881764
84	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06792920
85	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06221156
86	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04237045
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03361778
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02886947
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02384816
90	RXR_22108803_ChIP-Seq_LS180_Human	1.02138069
91	KDM2B_26808549_Chip-Seq_REH_Human	1.02031881
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01435040
93	JUN_21703547_ChIP-Seq_K562_Human	1.00651911
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00431327
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99378429
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96394937
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95431514
98	SMRT_27268052_Chip-Seq_Bcells_Human	0.94957914
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94272286
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.92832428

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	6.00302108
2	MP0003183_abnormal_peptide_metabolism	5.04692539
3	MP0003878_abnormal_ear_physiology	4.34205711
4	MP0005377_hearing/vestibular/ear_phenot	4.34205711
5	MP0008877_abnormal_DNA_methylation	4.15327123
6	MP0006292_abnormal_olfactory_placode	3.24250373
7	MP0003011_delayed_dark_adaptation	2.98632227
8	MP0003787_abnormal_imprinting	2.83903204
9	MP0003136_yellow_coat_color	2.63157580
10	MP0001485_abnormal_pinna_reflex	2.61943928
11	MP0000569_abnormal_digit_pigmentation	2.32204132
12	MP0005551_abnormal_eye_electrophysiolog	2.23856961
13	MP0001501_abnormal_sleep_pattern	2.19522054
14	MP0005248_abnormal_Harderian_gland	1.89160924
15	MP0006276_abnormal_autonomic_nervous	1.82209635
16	MP0004142_abnormal_muscle_tone	1.77404193
17	MP0001486_abnormal_startle_reflex	1.77050671
18	MP0009046_muscle_twitch	1.74335891
19	MP0000015_abnormal_ear_pigmentation	1.67222903
20	MP0002653_abnormal_ependyma_morphology	1.65382551
21	MP0000631_abnormal_neuroendocrine_gland	1.64006680
22	MP0003879_abnormal_hair_cell	1.62173742
23	MP0002736_abnormal_nociception_after	1.61491147
24	MP0004381_abnormal_hair_follicle	1.61181996
25	MP0000371_diluted_coat_color	1.61144011
26	MP0005075_abnormal_melanosome_morpholog	1.59631500
27	MP0002638_abnormal_pupillary_reflex	1.56028996
28	MP0001529_abnormal_vocalization	1.52458963
29	MP0005646_abnormal_pituitary_gland	1.52284084
30	MP0000427_abnormal_hair_cycle	1.48954207
31	MP0002075_abnormal_coat/hair_pigmentati	1.46683028
32	MP0002272_abnormal_nervous_system	1.46648317
33	MP0000372_irregular_coat_pigmentation	1.42732932
34	MP0001542_abnormal_bone_strength	1.41724203
35	MP0008058_abnormal_DNA_repair	1.39599204
36	MP0004742_abnormal_vestibular_system	1.38092616
37	MP0005386_behavior/neurological_phenoty	1.35874052
38	MP0004924_abnormal_behavior	1.35874052
39	MP0009745_abnormal_behavioral_response	1.32194237
40	MP0005253_abnormal_eye_physiology	1.31404938
41	MP0005499_abnormal_olfactory_system	1.31165956
42	MP0005394_taste/olfaction_phenotype	1.31165956
43	MP0008057_abnormal_DNA_replication	1.28905694
44	MP0004147_increased_porphyrin_level	1.28128803
45	MP0001968_abnormal_touch/_nociception	1.25423481
46	MP0009780_abnormal_chondrocyte_physiolo	1.24171050
47	MP0008789_abnormal_olfactory_epithelium	1.23090664
48	MP0008872_abnormal_physiological_respon	1.22002727
49	MP0002090_abnormal_vision	1.20903551
50	MP0001984_abnormal_olfaction	1.17990437
51	MP0002095_abnormal_skin_pigmentation	1.17953377
52	MP0001440_abnormal_grooming_behavior	1.17900570
53	MP0002229_neurodegeneration	1.07076657
54	MP0003186_abnormal_redox_activity	1.06909516
55	MP0005174_abnormal_tail_pigmentation	1.05922723
56	MP0000778_abnormal_nervous_system	1.05796104
57	MP0010386_abnormal_urinary_bladder	1.05201554
58	MP0003880_abnormal_central_pattern	1.04536279
59	MP0001963_abnormal_hearing_physiology	1.04464159
60	MP0001986_abnormal_taste_sensitivity	1.02873845
61	MP0000026_abnormal_inner_ear	1.02407054
62	MP0002127_abnormal_cardiovascular_syste	1.01574814
63	MP0001186_pigmentation_phenotype	0.99783931
64	MP0002572_abnormal_emotion/affect_behav	0.99514811
65	MP0002067_abnormal_sensory_capabilities	0.98672531
66	MP0004859_abnormal_synaptic_plasticity	0.93398302
67	MP0002064_seizures	0.90825648
68	MP0002938_white_spotting	0.89100159
69	MP0003121_genomic_imprinting	0.87669978
70	MP0001905_abnormal_dopamine_level	0.87604940
71	MP0003195_calcinosis	0.86671798
72	MP0002063_abnormal_learning/memory/cond	0.85863300
73	MP0002735_abnormal_chemical_nociception	0.84986517
74	MP0003806_abnormal_nucleotide_metabolis	0.84749897
75	MP0003635_abnormal_synaptic_transmissio	0.82426639
76	MP0005389_reproductive_system_phenotype	0.81847054
77	MP0001919_abnormal_reproductive_system	0.81512922
78	MP0005195_abnormal_posterior_eye	0.73844794
79	MP0000230_abnormal_systemic_arterial	0.73268030
80	MP0001293_anophthalmia	0.72965187
81	MP0002928_abnormal_bile_duct	0.72048069
82	MP0003137_abnormal_impulse_conducting	0.71369590
83	MP0002210_abnormal_sex_determination	0.69409846
84	MP0003698_abnormal_male_reproductive	0.68470653
85	MP0002752_abnormal_somatic_nervous	0.68105978
86	MP0002277_abnormal_respiratory_mucosa	0.67785143
87	MP0005423_abnormal_somatic_nervous	0.67461799
88	MP0001929_abnormal_gametogenesis	0.66735428
89	MP0002557_abnormal_social/conspecific_i	0.65626492
90	MP0002909_abnormal_adrenal_gland	0.63381382
91	MP0005410_abnormal_fertilization	0.63355613
92	MP0000653_abnormal_sex_gland	0.62458315
93	MP0002882_abnormal_neuron_morphology	0.60136401
94	MP0005391_vision/eye_phenotype	0.59880557
95	MP0001324_abnormal_eye_pigmentation	0.59828219
96	MP0003122_maternal_imprinting	0.59364397
97	MP0001970_abnormal_pain_threshold	0.57191507
98	MP0004145_abnormal_muscle_electrophysio	0.56308649
99	MP0000613_abnormal_salivary_gland	0.55534035
100	MP0005671_abnormal_response_to	0.55320912

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.91031099
2	Sensory axonal neuropathy (HP:0003390)	4.36947016
3	Chronic bronchitis (HP:0004469)	3.40926239
4	Rib fusion (HP:0000902)	3.29806102
5	Congenital stationary night blindness (HP:0007642)	3.24773553
6	Dyschromatopsia (HP:0007641)	3.19093766
7	Focal motor seizures (HP:0011153)	3.07241153
8	Delayed CNS myelination (HP:0002188)	3.00165288
9	Absent speech (HP:0001344)	2.98808186
10	Abnormality of the renal cortex (HP:0011035)	2.96219233
11	Abnormal respiratory motile cilium physiology (HP:0012261)	2.92061780
12	Atonic seizures (HP:0010819)	2.90045301
13	Abnormal drinking behavior (HP:0030082)	2.88275656
14	Polydipsia (HP:0001959)	2.88275656
15	Cerebral hypomyelination (HP:0006808)	2.78835357
16	Tubulointerstitial nephritis (HP:0001970)	2.77632961
17	True hermaphroditism (HP:0010459)	2.76468367
18	Cortical visual impairment (HP:0100704)	2.73018013
19	Absence seizures (HP:0002121)	2.69300949
20	Hyperglycinuria (HP:0003108)	2.69232270
21	Volvulus (HP:0002580)	2.69190780
22	Epileptic encephalopathy (HP:0200134)	2.69025138
23	Retinitis pigmentosa (HP:0000510)	2.67925431
24	Poikiloderma (HP:0001029)	2.67095886
25	Dialeptic seizures (HP:0011146)	2.56548286
26	Pancreatic fibrosis (HP:0100732)	2.54039149
27	Methylmalonic aciduria (HP:0012120)	2.48968488
28	Delayed myelination (HP:0012448)	2.47285563
29	Tented upper lip vermilion (HP:0010804)	2.42265650
30	Aplastic anemia (HP:0001915)	2.40329506
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.40032853
32	Nephronophthisis (HP:0000090)	2.38899624
33	Pancreatic cysts (HP:0001737)	2.37574317
34	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.36897379
35	Nephrogenic diabetes insipidus (HP:0009806)	2.35585380
36	Renal cortical cysts (HP:0000803)	2.34828248
37	Hyperglycinemia (HP:0002154)	2.33049173
38	Abnormality of midbrain morphology (HP:0002418)	2.29542915
39	Molar tooth sign on MRI (HP:0002419)	2.29542915
40	Rhinitis (HP:0012384)	2.28216486
41	Attenuation of retinal blood vessels (HP:0007843)	2.27971903
42	Medial flaring of the eyebrow (HP:0010747)	2.25655290
43	Abolished electroretinogram (ERG) (HP:0000550)	2.25459045
44	Gait imbalance (HP:0002141)	2.24043533
45	Abnormal biliary tract physiology (HP:0012439)	2.21425500
46	Bile duct proliferation (HP:0001408)	2.21425500
47	Tubular atrophy (HP:0000092)	2.21188700
48	Methylmalonic acidemia (HP:0002912)	2.19493342
49	Congenital primary aphakia (HP:0007707)	2.19270648
50	Testicular atrophy (HP:0000029)	2.19264943
51	Polyuria (HP:0000103)	2.19220148
52	Growth hormone deficiency (HP:0000824)	2.19067923
53	Decreased circulating renin level (HP:0003351)	2.17451507
54	Hypsarrhythmia (HP:0002521)	2.16367002
55	Chronic hepatic failure (HP:0100626)	2.15948966
56	Abnormality of serine family amino acid metabolism (HP:0010894)	2.15666855
57	Abnormality of glycine metabolism (HP:0010895)	2.15666855
58	Acute encephalopathy (HP:0006846)	2.10636424
59	Focal seizures (HP:0007359)	2.09949078
60	Gastrointestinal atresia (HP:0002589)	2.08607187
61	Absent/shortened dynein arms (HP:0200106)	2.08553603
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.08553603
63	Hyperventilation (HP:0002883)	2.05945952
64	Febrile seizures (HP:0002373)	2.04011065
65	EEG with generalized epileptiform discharges (HP:0011198)	2.00702256
66	Metaphyseal dysplasia (HP:0100255)	1.99771262
67	Intestinal atresia (HP:0011100)	1.99584168
68	Microvesicular hepatic steatosis (HP:0001414)	1.99300693
69	Status epilepticus (HP:0002133)	1.97477430
70	Epileptiform EEG discharges (HP:0011182)	1.96081830
71	Amyotrophic lateral sclerosis (HP:0007354)	1.95079351
72	Tubulointerstitial abnormality (HP:0001969)	1.91181732
73	Broad foot (HP:0001769)	1.90508903
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90424806
75	Adactyly (HP:0009776)	1.87034726
76	Abnormality of the renal medulla (HP:0100957)	1.86014663
77	Short tibia (HP:0005736)	1.84876258
78	Limb hypertonia (HP:0002509)	1.84025901
79	Bronchitis (HP:0012387)	1.82267169
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.82056296
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.82056296
82	Abnormality of the lower motor neuron (HP:0002366)	1.81402814
83	Sclerocornea (HP:0000647)	1.80445661
84	Postnatal microcephaly (HP:0005484)	1.79768461
85	Medulloblastoma (HP:0002885)	1.78419523
86	Palpebral edema (HP:0100540)	1.78142327
87	Ketoacidosis (HP:0001993)	1.77621634
88	CNS demyelination (HP:0007305)	1.77154792
89	Pachygyria (HP:0001302)	1.76885617
90	CNS hypomyelination (HP:0003429)	1.76853309
91	Ependymoma (HP:0002888)	1.76175208
92	Severe visual impairment (HP:0001141)	1.75784970
93	Menstrual irregularities (HP:0000858)	1.73999009
94	Septo-optic dysplasia (HP:0100842)	1.73301532
95	Progressive cerebellar ataxia (HP:0002073)	1.72535639
96	Retinal dysplasia (HP:0007973)	1.72307461
97	Anophthalmia (HP:0000528)	1.72213789
98	Ketosis (HP:0001946)	1.71806339
99	Optic nerve hypoplasia (HP:0000609)	1.71617062
100	Brushfield spots (HP:0001088)	1.71034765

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	6.35573822
2	FRK	5.66004682
3	NUAK1	3.62762160
4	TXK	2.86651978
5	WNK3	2.77226376
6	MAPKAPK3	2.67773338
7	EEF2K	2.05355212
8	BCKDK	1.97427881
9	BMPR1B	1.95855326
10	MAP3K12	1.95154196
11	ACVR1B	1.88768349
12	MAPK13	1.70551456
13	TAOK3	1.59689451
14	STK16	1.54179281
15	NTRK3	1.52516149
16	PDK2	1.51793132
17	MAP2K4	1.51282586
18	OXSR1	1.51065549
19	SIK3	1.50876114
20	DYRK2	1.42250025
21	IKBKE	1.37977936
22	MARK1	1.36448076
23	IRAK1	1.35462177
24	ADRBK2	1.35294954
25	EPHA4	1.34650203
26	MAP3K4	1.33750547
27	CDK19	1.32353644
28	IRAK4	1.26939682
29	MAP3K5	1.26805511
30	SIK2	1.24564115
31	MST4	1.17818981
32	STK39	1.15671870
33	MAPKAPK5	1.14918757
34	CASK	1.12779570
35	DMPK	1.06579626
36	PLK2	1.03400730
37	MAP3K10	1.03371321
38	BCR	0.94265849
39	MUSK	0.94146471
40	PIK3CA	0.93276170
41	MAP3K6	0.93199914
42	PIM2	0.86382265
43	GRK1	0.84264249
44	RAF1	0.82322695
45	BRD4	0.75934810
46	NEK6	0.71662560
47	PRKCQ	0.70736106
48	TRPM7	0.70235963
49	RPS6KB2	0.70205123
50	PINK1	0.69735721
51	ZAK	0.68686104
52	AURKA	0.68104008
53	MAPK12	0.65598384
54	YES1	0.65596657
55	NLK	0.65421437
56	TIE1	0.62525879
57	PRKCE	0.59665343
58	DYRK1B	0.59363629
59	ADRBK1	0.57664497
60	GRK7	0.54438686
61	CAMK2B	0.54203310
62	TEC	0.51247969
63	VRK1	0.50822505
64	STK3	0.50054675
65	CDC7	0.49279057
66	CDK8	0.48485818
67	PRKACA	0.46569431
68	KIT	0.45872622
69	IRAK2	0.44575645
70	CAMK1	0.43510110
71	TNK2	0.43129016
72	RPS6KA4	0.42865022
73	TGFBR1	0.42643093
74	PLK4	0.42480446
75	ERBB4	0.41607238
76	PAK3	0.41385977
77	CAMK2A	0.40460036
78	INSRR	0.38732290
79	MAP2K7	0.38199548
80	CAMKK2	0.37435980
81	PRKCA	0.37185915
82	MAPK7	0.35878385
83	NME1	0.35047061
84	CAMK2G	0.34929584
85	ATR	0.34595094
86	CAMK2D	0.32791176
87	PKN1	0.32668012
88	PRKCZ	0.30443138
89	DYRK1A	0.29310728
90	EIF2AK3	0.27740448
91	PRKG1	0.27602128
92	PTK2B	0.27197849
93	ILK	0.26528251
94	NEK9	0.26329316
95	ITK	0.26042957
96	ERBB3	0.25282026
97	WNK4	0.24644958
98	PNCK	0.24130954
99	CHEK1	0.24075654
100	IGF1R	0.23908750

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Propanoate metabolism_Homo sapiens_hsa00640	2.86058232
2	Nicotine addiction_Homo sapiens_hsa05033	2.75091432
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.73993770
4	Protein export_Homo sapiens_hsa03060	2.59458380
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.57799897
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.51617750
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.47621726
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.46988979
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.40639654
10	Phototransduction_Homo sapiens_hsa04744	2.39985616
11	Butanoate metabolism_Homo sapiens_hsa00650	2.19951060
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17414973
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.15792676
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.10385982
15	Basal transcription factors_Homo sapiens_hsa03022	2.00526898
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.98976716
17	Peroxisome_Homo sapiens_hsa04146	1.87247719
18	RNA degradation_Homo sapiens_hsa03018	1.73926456
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.73112833
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.73104585
21	RNA polymerase_Homo sapiens_hsa03020	1.69880332
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.67828434
23	Morphine addiction_Homo sapiens_hsa05032	1.63895282
24	Taste transduction_Homo sapiens_hsa04742	1.63792183
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.59797233
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.52254770
27	Proteasome_Homo sapiens_hsa03050	1.51448103
28	Circadian entrainment_Homo sapiens_hsa04713	1.45707532
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.44581722
30	Homologous recombination_Homo sapiens_hsa03440	1.44452059
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36169567
32	GABAergic synapse_Homo sapiens_hsa04727	1.27500614
33	Base excision repair_Homo sapiens_hsa03410	1.21485497
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.20357304
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.19312542
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.18916414
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14581571
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.13149296
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.12917270
40	Serotonergic synapse_Homo sapiens_hsa04726	1.12032312
41	Olfactory transduction_Homo sapiens_hsa04740	1.11977205
42	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.06356605
43	Parkinsons disease_Homo sapiens_hsa05012	1.03405110
44	Sulfur relay system_Homo sapiens_hsa04122	0.98202942
45	Folate biosynthesis_Homo sapiens_hsa00790	0.93494159
46	cAMP signaling pathway_Homo sapiens_hsa04024	0.93253253
47	Huntingtons disease_Homo sapiens_hsa05016	0.92966094
48	Circadian rhythm_Homo sapiens_hsa04710	0.90066743
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86131098
50	Histidine metabolism_Homo sapiens_hsa00340	0.83770970
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.83601312
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83438355
53	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.82607862
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81084383
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.79066798
56	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.78535416
57	Purine metabolism_Homo sapiens_hsa00230	0.77575607
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.77419130
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77407966
60	Regulation of autophagy_Homo sapiens_hsa04140	0.73692826
61	Long-term depression_Homo sapiens_hsa04730	0.72454848
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71537176
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68473429
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.67538592
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66051258
66	Cholinergic synapse_Homo sapiens_hsa04725	0.65518334
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65013526
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63396350
69	Insulin secretion_Homo sapiens_hsa04911	0.61926056
70	Retinol metabolism_Homo sapiens_hsa00830	0.61401617
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59344735
72	Glutathione metabolism_Homo sapiens_hsa00480	0.58424556
73	Salivary secretion_Homo sapiens_hsa04970	0.58200793
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.55793007
75	Sulfur metabolism_Homo sapiens_hsa00920	0.55334977
76	Metabolic pathways_Homo sapiens_hsa01100	0.54568129
77	Fatty acid elongation_Homo sapiens_hsa00062	0.53341281
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.50642987
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50565422
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49748453
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48893779
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.47013479
83	Renin secretion_Homo sapiens_hsa04924	0.46875886
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.43003558
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42872716
86	Mismatch repair_Homo sapiens_hsa03430	0.42685440
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39015212
88	Gastric acid secretion_Homo sapiens_hsa04971	0.38728497
89	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.38113403
90	RNA transport_Homo sapiens_hsa03013	0.37245987
91	Cardiac muscle contraction_Homo sapiens_hsa04260	0.37029800
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.36925288
93	Amphetamine addiction_Homo sapiens_hsa05031	0.35275568
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34360119
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33696631
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33356857
97	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.30845552
98	Cocaine addiction_Homo sapiens_hsa05030	0.30315288
99	Melanoma_Homo sapiens_hsa05218	0.28008367
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.27000674

MAP2K4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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