MAP2K5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-proline hydroxylation (GO:0019511)5.18230109
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.03568351
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.92611310
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92611310
5heterochromatin organization (GO:0070828)4.86712462
6DNA unwinding involved in DNA replication (GO:0006268)4.78152015
7establishment of mitochondrion localization (GO:0051654)4.72713661
8positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.71627669
9mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.71627669
10microtubule severing (GO:0051013)4.51450268
11protein hydroxylation (GO:0018126)4.43742028
12chaperone-mediated protein transport (GO:0072321)4.30756658
13regulation of synaptic vesicle exocytosis (GO:2000300)4.20223723
14ribosomal small subunit assembly (GO:0000028)4.17118117
154-hydroxyproline metabolic process (GO:0019471)4.12333828
16positive regulation of mitochondrial fission (GO:0090141)4.08714869
17DNA deamination (GO:0045006)4.08588796
18positive regulation of gamma-delta T cell activation (GO:0046645)3.97890121
19spliceosomal tri-snRNP complex assembly (GO:0000244)3.95136369
20protein import into peroxisome matrix (GO:0016558)3.91474949
21positive regulation of male gonad development (GO:2000020)3.87628646
22labyrinthine layer development (GO:0060711)3.85091573
23antigen processing and presentation of endogenous antigen (GO:0019883)3.81404190
24histone H4 deacetylation (GO:0070933)3.79973576
25translesion synthesis (GO:0019985)3.79558128
26regulation of necroptotic process (GO:0060544)3.71840614
27protein polyglutamylation (GO:0018095)3.70477907
28positive regulation of B cell differentiation (GO:0045579)3.70144737
29negative regulation of necroptotic process (GO:0060546)3.68015048
30purine-containing compound salvage (GO:0043101)3.67121809
31negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.65245784
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62315074
33positive regulation of mitochondrial membrane permeability (GO:0035794)3.59961620
34pyrimidine nucleobase catabolic process (GO:0006208)3.57414958
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57260259
36establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.54122611
37mitochondrion transport along microtubule (GO:0047497)3.54122611
38necroptotic process (GO:0070266)3.50679622
39cell migration in hindbrain (GO:0021535)3.48828937
40DNA strand elongation involved in DNA replication (GO:0006271)3.48657730
41peptidyl-arginine omega-N-methylation (GO:0035247)3.47494543
42oxaloacetate metabolic process (GO:0006107)3.44947654
43protein retention in ER lumen (GO:0006621)3.44075564
44alternative mRNA splicing, via spliceosome (GO:0000380)3.42909808
45antigen processing and presentation via MHC class Ib (GO:0002475)3.42281325
46cranial nerve morphogenesis (GO:0021602)3.38218131
47definitive hemopoiesis (GO:0060216)3.35030411
48negative regulation of erythrocyte differentiation (GO:0045647)3.33319041
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32539299
50regulation of gamma-delta T cell differentiation (GO:0045586)3.28623434
51DNA strand elongation (GO:0022616)3.24155607
52peptidyl-lysine dimethylation (GO:0018027)3.23377611
53regulation of synaptic vesicle transport (GO:1902803)3.22798260
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21961598
55purine nucleotide salvage (GO:0032261)3.20805732
56peroxisomal transport (GO:0043574)3.19215625
57protein insertion into membrane (GO:0051205)3.19021696
58peptidyl-arginine methylation (GO:0018216)3.17044208
59peptidyl-arginine N-methylation (GO:0035246)3.17044208
60regulation of NFAT protein import into nucleus (GO:0051532)3.15853354
61negative regulation of DNA-templated transcription, elongation (GO:0032785)3.13419974
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11480403
63protein-DNA complex disassembly (GO:0032986)3.10685156
64nucleosome disassembly (GO:0006337)3.10685156
65cerebellar granule cell differentiation (GO:0021707)3.10480366
66ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.09958465
67synaptic vesicle exocytosis (GO:0016079)3.09030452
68creatine metabolic process (GO:0006600)3.06201082
69proximal/distal pattern formation (GO:0009954)3.05509773
70alpha-linolenic acid metabolic process (GO:0036109)3.04775543
71telomere maintenance via semi-conservative replication (GO:0032201)3.04194701
72positive regulation of granulocyte differentiation (GO:0030854)3.03976411
73positive regulation of dendritic spine morphogenesis (GO:0061003)3.00946075
74coronary vasculature morphogenesis (GO:0060977)2.99591947
75protein targeting to peroxisome (GO:0006625)2.98802497
76establishment of protein localization to peroxisome (GO:0072663)2.98802497
77protein localization to peroxisome (GO:0072662)2.98802497
78regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.98254595
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97975908
80cellular hyperosmotic response (GO:0071474)2.97881580
81IMP metabolic process (GO:0046040)2.97410819
82response to nitric oxide (GO:0071731)2.96221269
83endosome to pigment granule transport (GO:0043485)2.94302274
84endosome to melanosome transport (GO:0035646)2.94302274
85glycolytic process (GO:0006096)2.92605106
86histone H3 deacetylation (GO:0070932)2.91888756
87regulation of necrotic cell death (GO:0010939)2.90742407
88viral transcription (GO:0019083)2.89661038
89intracellular estrogen receptor signaling pathway (GO:0030520)2.89619684
90regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89452389
91synaptic vesicle maturation (GO:0016188)2.88768530
92negative regulation of cell size (GO:0045792)2.88349964
93histone H3-K9 methylation (GO:0051567)2.87205618
94regulation of gamma-delta T cell activation (GO:0046643)2.86765684
95pentose-phosphate shunt (GO:0006098)2.85516841
96regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84566277
97cerebral cortex neuron differentiation (GO:0021895)2.83524452
98mature B cell differentiation involved in immune response (GO:0002313)2.81656638
99IMP biosynthetic process (GO:0006188)2.80969871
100postsynaptic membrane organization (GO:0001941)2.80694875
101microtubule nucleation (GO:0007020)2.80512280
102histone H3-K9 demethylation (GO:0033169)2.80471747
103central nervous system projection neuron axonogenesis (GO:0021952)2.78634391
104Arp2/3 complex-mediated actin nucleation (GO:0034314)2.78316680
105negative regulation of RNA splicing (GO:0033119)2.77032637
106mitochondrion localization (GO:0051646)2.76147032
107positive regulation of receptor biosynthetic process (GO:0010870)2.75890739
108negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.75584512
109peripheral nervous system neuron development (GO:0048935)2.75244546
110DNA replication initiation (GO:0006270)2.74179256
111negative regulation of necrotic cell death (GO:0060547)2.73418795
1123-UTR-mediated mRNA stabilization (GO:0070935)2.73280586
113mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.73216554
114translational elongation (GO:0006414)2.72605892
115regulation of meiosis I (GO:0060631)2.72304497
116T cell homeostasis (GO:0043029)2.71924179
117T cell apoptotic process (GO:0070231)2.70518244
118growth hormone secretion (GO:0030252)2.68377090
119left/right pattern formation (GO:0060972)2.67089243
120lipopolysaccharide metabolic process (GO:0008653)2.66935506
121translational termination (GO:0006415)2.66507193
122glycine metabolic process (GO:0006544)2.65878495
123histone H3-K9 modification (GO:0061647)2.65525807
124lipopolysaccharide biosynthetic process (GO:0009103)2.65432109
125neurotransmitter-gated ion channel clustering (GO:0072578)2.64618602
126natural killer cell differentiation (GO:0001779)2.64474462
127NIK/NF-kappaB signaling (GO:0038061)2.62920038
128tricarboxylic acid metabolic process (GO:0072350)2.62874488
129cellular ketone body metabolic process (GO:0046950)2.61216766
130killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.59509959
131disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.59509959
132negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.58514868
133negative regulation of cell cycle G2/M phase transition (GO:1902750)2.58392950
134snRNA processing (GO:0016180)2.57569233
135mRNA splice site selection (GO:0006376)2.55073538
136cellular response to interleukin-4 (GO:0071353)2.54596059
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54595278
138pre-miRNA processing (GO:0031054)2.53912885
139megakaryocyte development (GO:0035855)2.53710164
140synaptonemal complex assembly (GO:0007130)2.53606238
141mast cell activation involved in immune response (GO:0002279)2.53492527
142mast cell degranulation (GO:0043303)2.53492527
143snRNA metabolic process (GO:0016073)2.53488050
144RNA localization (GO:0006403)2.53018454
145postreplication repair (GO:0006301)2.52476460
146positive regulation of synapse maturation (GO:0090129)2.52268349
147secretory granule organization (GO:0033363)2.52041046
148left/right axis specification (GO:0070986)2.51568127
149B cell receptor signaling pathway (GO:0050853)2.51446491
150nucleobase catabolic process (GO:0046113)2.51072163
1512-oxoglutarate metabolic process (GO:0006103)2.50321994
152mast cell activation (GO:0045576)2.50220519
153negative regulation of myotube differentiation (GO:0010832)2.50092539
154regulation of B cell receptor signaling pathway (GO:0050855)2.50078932
155defense response to protozoan (GO:0042832)2.49438592
156spinal cord association neuron differentiation (GO:0021527)2.47549378
157nucleotide salvage (GO:0043173)2.46694306
158regulation of mitochondrial fission (GO:0090140)2.42748678
159G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.41865823
160layer formation in cerebral cortex (GO:0021819)2.41676547
161histone H4-K8 acetylation (GO:0043982)2.41282196
162histone H4-K5 acetylation (GO:0043981)2.41282196
163granulocyte differentiation (GO:0030851)2.40943017
164erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.40115993
165L-phenylalanine metabolic process (GO:0006558)2.40115993
166platelet dense granule organization (GO:0060155)2.40110569
167lymphocyte apoptotic process (GO:0070227)2.39812453
168GDP-mannose metabolic process (GO:0019673)2.39576475
169tricarboxylic acid cycle (GO:0006099)2.39281007
170organelle transport along microtubule (GO:0072384)2.39135288
171valine metabolic process (GO:0006573)2.39033345
172synaptic vesicle endocytosis (GO:0048488)2.38788373
173oxidative phosphorylation (GO:0006119)2.38661910
174succinate metabolic process (GO:0006105)2.38542486
175negative regulation of phagocytosis (GO:0050765)2.37300096
176regulation of fatty acid oxidation (GO:0046320)2.36759992
177epithelial cell differentiation involved in kidney development (GO:0035850)2.36554452
178regulation of protein heterodimerization activity (GO:0043497)2.36499323
179viral life cycle (GO:0019058)2.36217626
180regulation of synapse structural plasticity (GO:0051823)2.36064568
181mature B cell differentiation (GO:0002335)2.35490137
182angiogenesis involved in wound healing (GO:0060055)2.35013209
183nerve growth factor signaling pathway (GO:0038180)2.34686752
184telomere maintenance via recombination (GO:0000722)2.34606584
185regulation of glutamate receptor signaling pathway (GO:1900449)2.34274300
186NADPH regeneration (GO:0006740)2.34194640
187regulation of fatty acid beta-oxidation (GO:0031998)2.34174641
188positive regulation of protein homodimerization activity (GO:0090073)2.33202146
189serine family amino acid biosynthetic process (GO:0009070)2.33088437
190auditory behavior (GO:0031223)2.33020715
191positive regulation of lamellipodium assembly (GO:0010592)2.32731152
192nucleoside salvage (GO:0043174)2.31020878
193glyoxylate metabolic process (GO:0046487)2.30829917
194regulation of B cell differentiation (GO:0045577)2.28397976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.48880052
2E2F7_22180533_ChIP-Seq_HELA_Human5.37798844
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40385259
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.37650854
5SCL_19346495_ChIP-Seq_HPC-7_Human3.34841764
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.26024696
7IGF1R_20145208_ChIP-Seq_DFB_Human3.18056504
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00933069
9MYC_22102868_ChIP-Seq_BL_Human2.99408630
10VDR_21846776_ChIP-Seq_THP-1_Human2.78033850
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.69390560
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.68013603
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67016471
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51198721
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.50267516
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.34173495
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.28693245
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10325378
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09040271
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04533968
21PKCTHETA_26484144_Chip-Seq_BREAST_Human2.02439496
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97834549
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94113930
24TCF7_22412390_ChIP-Seq_EML_Mouse1.92813236
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90739136
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.88845469
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88353408
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87662737
29MAF_26560356_Chip-Seq_TH1_Human1.80472949
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79039877
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76962413
32CIITA_25753668_ChIP-Seq_RAJI_Human1.75272556
33UTX_26944678_Chip-Seq_JUKART_Human1.72374518
34* VDR_24763502_ChIP-Seq_THP-1_Human1.71929484
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70447211
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.66761055
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64845695
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.64091119
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63594992
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63085090
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62288813
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.61995046
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.60330110
44GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60060336
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59476190
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58561069
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57738905
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.56857423
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56449456
50LXR_22292898_ChIP-Seq_THP-1_Human1.56386643
51XRN2_22483619_ChIP-Seq_HELA_Human1.55885310
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54598791
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.53270432
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52605678
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.52230911
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52201392
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51603177
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51512087
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50744168
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50089046
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49616625
62MYB_26560356_Chip-Seq_TH2_Human1.49061360
63SPI1_23547873_ChIP-Seq_NB4_Human1.48929149
64* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48904266
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48538162
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47797221
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47493339
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44488648
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43702291
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.43639482
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43459982
72FOXP3_21729870_ChIP-Seq_TREG_Human1.43172519
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42542654
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42178709
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41452187
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39586204
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38841551
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38609986
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.37760113
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37519668
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.36782967
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.35691286
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.34770724
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34028785
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33321022
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32764615
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32167039
88WDR5_24793694_ChIP-Seq_LNCAP_Human1.32109406
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31822588
90* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31334277
91MYB_26560356_Chip-Seq_TH1_Human1.30045863
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29888244
93* TFEB_21752829_ChIP-Seq_HELA_Human1.29611413
94* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27873864
95* REST_18959480_ChIP-ChIP_MESCs_Mouse1.27657220
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27447679
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27158113
98P68_20966046_ChIP-Seq_HELA_Human1.26233610
99E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26140420
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25487060
101* GABP_19822575_ChIP-Seq_HepG2_Human1.24889366
102* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23665616
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.23112612
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23104352
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22599791
106KDM2B_26808549_Chip-Seq_K562_Human1.22450236
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.22028043
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21522814
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21508690
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21161520
111* BCL6_27268052_Chip-Seq_Bcells_Human1.20305576
112* SPI1_23127762_ChIP-Seq_K562_Human1.19903590
113KDM2B_26808549_Chip-Seq_DND41_Human1.19732287
114EST1_17652178_ChIP-ChIP_JURKAT_Human1.17908727
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17645721
116RNF2_27304074_Chip-Seq_NSC_Mouse1.17475009
117STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17225773
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.17103379
119* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16934239
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16685734
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16241183
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14098439
123* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14024734
124* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12868522
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11404190
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10756096
127PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10742770
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10178345
129SMC4_20622854_ChIP-Seq_HELA_Human1.09607934
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09583683
131DROSHA_22980978_ChIP-Seq_HELA_Human1.09283838
132* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09144490
133* MAF_26560356_Chip-Seq_TH2_Human1.06906184
134SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06724543
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06648046
136SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06644983
137MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06499797
138CREB1_26743006_Chip-Seq_LNCaP_Human1.06448328
139* NCOR1_26117541_ChIP-Seq_K562_Human1.05613390
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05296483
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02989450
142SOX3_22085726_ChIP-Seq_NPCs_Mouse1.01961629
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01806582
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01662716
145ETS1_20019798_ChIP-Seq_JURKAT_Human1.01008969
146CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00334530
147ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00327801
148* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99797362
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.99361947
150E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99254173
151* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98951996
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98609213
153* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98147843
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97919877
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97299698
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.96741083
157JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95640459
158PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94027612
159GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93895336
160TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93801968
161REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93540011
162SA1_27219007_Chip-Seq_ERYTHROID_Human0.92647700
163TP63_19390658_ChIP-ChIP_HaCaT_Human0.92580733
164* REST_21632747_ChIP-Seq_MESCs_Mouse0.92398924
165EZH2_27304074_Chip-Seq_ESCs_Mouse0.92328805
166IRF1_19129219_ChIP-ChIP_H3396_Human0.91167143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.25991385
2MP0005423_abnormal_somatic_nervous4.08858856
3MP0005171_absent_coat_pigmentation3.74048143
4MP0005451_abnormal_body_composition3.24730691
5MP0002396_abnormal_hematopoietic_system3.00284167
6MP0000685_abnormal_immune_system2.84800353
7MP0009840_abnormal_foam_cell2.75893802
8MP0004808_abnormal_hematopoietic_stem2.73975380
9MP0002653_abnormal_ependyma_morphology2.72923787
10MP0005464_abnormal_platelet_physiology2.58307098
11MP0002139_abnormal_hepatobiliary_system2.51871603
12MP0001545_abnormal_hematopoietic_system2.50864665
13MP0005397_hematopoietic_system_phenotyp2.50864665
14MP0005409_darkened_coat_color2.37418834
15MP0001835_abnormal_antigen_presentation2.35240072
16MP0003880_abnormal_central_pattern2.28920780
17MP0004233_abnormal_muscle_weight2.21968844
18MP0003635_abnormal_synaptic_transmissio2.14749047
19MP0005360_urolithiasis2.06572195
20MP0005365_abnormal_bile_salt2.06387651
21MP0005174_abnormal_tail_pigmentation2.04875473
22MP0003136_yellow_coat_color2.00654043
23MP0001873_stomach_inflammation1.99221330
24MP0002249_abnormal_larynx_morphology1.98777144
25MP0009278_abnormal_bone_marrow1.95466855
26MP0002398_abnormal_bone_marrow1.92525084
27MP0003943_abnormal_hepatobiliary_system1.88915762
28MP0001188_hyperpigmentation1.85484623
29MP0003172_abnormal_lysosome_physiology1.85092376
30MP0003763_abnormal_thymus_physiology1.84215347
31MP0005075_abnormal_melanosome_morpholog1.81273374
32MP0003436_decreased_susceptibility_to1.78565981
33MP0005085_abnormal_gallbladder_physiolo1.76129829
34MP0003191_abnormal_cellular_cholesterol1.75660385
35MP0003300_gastrointestinal_ulcer1.73800861
36MP0005671_abnormal_response_to1.72215319
37MP0005499_abnormal_olfactory_system1.71040394
38MP0005394_taste/olfaction_phenotype1.71040394
39MP0000569_abnormal_digit_pigmentation1.69896505
40MP0000689_abnormal_spleen_morphology1.69691340
41MP0002722_abnormal_immune_system1.67485019
42MP0003656_abnormal_erythrocyte_physiolo1.67080671
43MP0001800_abnormal_humoral_immune1.66872604
44MP0000778_abnormal_nervous_system1.66451360
45MP0008569_lethality_at_weaning1.64756062
46MP0004145_abnormal_muscle_electrophysio1.64598605
47MP0003385_abnormal_body_wall1.63311539
48MP0002822_catalepsy1.62697480
49MP0006035_abnormal_mitochondrial_morpho1.62532016
50MP0002063_abnormal_learning/memory/cond1.60553976
51MP0004270_analgesia1.59801809
52MP0004130_abnormal_muscle_cell1.59270988
53MP0008995_early_reproductive_senescence1.58048090
54MP0004147_increased_porphyrin_level1.55131567
55MP0000716_abnormal_immune_system1.53605753
56MP0002429_abnormal_blood_cell1.53176054
57MP0000703_abnormal_thymus_morphology1.51557456
58MP0002452_abnormal_antigen_presenting1.51125266
59MP0001853_heart_inflammation1.50984710
60MP0004811_abnormal_neuron_physiology1.50933118
61MP0005025_abnormal_response_to1.50667705
62MP0002723_abnormal_immune_serum1.48551269
63MP0009785_altered_susceptibility_to1.45043710
64MP0000465_gastrointestinal_hemorrhage1.43938395
65MP0002420_abnormal_adaptive_immunity1.43400484
66MP0010368_abnormal_lymphatic_system1.42492757
67MP0001529_abnormal_vocalization1.42011748
68MP0001819_abnormal_immune_cell1.40506752
69MP0000955_abnormal_spinal_cord1.39388710
70MP0010094_abnormal_chromosome_stability1.38459326
71MP0005670_abnormal_white_adipose1.38278035
72MP0002166_altered_tumor_susceptibility1.37212648
73MP0000598_abnormal_liver_morphology1.35432658
74MP0010329_abnormal_lipoprotein_level1.34715341
75MP0000681_abnormal_thyroid_gland1.33719204
76MP0002064_seizures1.33080613
77MP0004858_abnormal_nervous_system1.31743983
78MP0008789_abnormal_olfactory_epithelium1.30609737
79MP0005584_abnormal_enzyme/coenzyme_acti1.29140846
80MP0001968_abnormal_touch/_nociception1.29019297
81MP0003252_abnormal_bile_duct1.28603058
82MP0000751_myopathy1.28308073
83MP0008007_abnormal_cellular_replicative1.28181384
84MP0002572_abnormal_emotion/affect_behav1.27147739
85MP0006054_spinal_hemorrhage1.26299439
86MP0001486_abnormal_startle_reflex1.25907973
87MP0004484_altered_response_of1.24607942
88MP0006082_CNS_inflammation1.23889906
89MP0006036_abnormal_mitochondrial_physio1.21429599
90MP0002933_joint_inflammation1.20628521
91MP0008875_abnormal_xenobiotic_pharmacok1.20299008
92MP0002419_abnormal_innate_immunity1.20243094
93MP0001270_distended_abdomen1.20142000
94MP0005387_immune_system_phenotype1.19386562
95MP0001790_abnormal_immune_system1.19386562
96MP0000609_abnormal_liver_physiology1.18640235
97MP0000759_abnormal_skeletal_muscle1.18141262
98MP0002735_abnormal_chemical_nociception1.18095030
99MP0003183_abnormal_peptide_metabolism1.17477082
100MP0005000_abnormal_immune_tolerance1.17327237
101MP0002882_abnormal_neuron_morphology1.16020042
102MP0005058_abnormal_lysosome_morphology1.15876201
103MP0003866_abnormal_defecation1.15604171
104MP0000049_abnormal_middle_ear1.15387790
105MP0001986_abnormal_taste_sensitivity1.14262292
106MP0003698_abnormal_male_reproductive1.14187652
107MP0003879_abnormal_hair_cell1.13972484
108MP0002269_muscular_atrophy1.13280383
109MP0002152_abnormal_brain_morphology1.11410848
110MP0003303_peritoneal_inflammation1.11375793
111MP0002106_abnormal_muscle_physiology1.10750669
112MP0003329_amyloid_beta_deposits1.10047573
113MP0003646_muscle_fatigue1.08558702
114MP0002405_respiratory_system_inflammati1.08325866
115MP0008469_abnormal_protein_level1.07863457
116MP0008932_abnormal_embryonic_tissue1.07590113
117MP0008260_abnormal_autophagy1.06876587
118MP0005319_abnormal_enzyme/_coenzyme1.05237592
119MP0000747_muscle_weakness1.04776637
120MP0002019_abnormal_tumor_incidence1.04746898
121MP0002067_abnormal_sensory_capabilities1.04059176
122MP0003942_abnormal_urinary_system1.03891356
123MP0004510_myositis1.03328054
124MP0004133_heterotaxia1.00849690
125MP0003077_abnormal_cell_cycle1.00664303
126MP0001502_abnormal_circadian_rhythm1.00292187
127MP0009333_abnormal_splenocyte_physiolog1.00049898
128MP0000358_abnormal_cell_content/0.99592559
129MP0000750_abnormal_muscle_regeneration0.99061512
130MP0004087_abnormal_muscle_fiber0.97981258
131MP0001845_abnormal_inflammatory_respons0.97542554
132MP0003861_abnormal_nervous_system0.96212667
133MP0002928_abnormal_bile_duct0.95681185
134MP0004947_skin_inflammation0.94485246
135MP0003806_abnormal_nucleotide_metabolis0.93492832
136MP0004185_abnormal_adipocyte_glucose0.92722632
137MP0002909_abnormal_adrenal_gland0.92109159
138MP0003123_paternal_imprinting0.91375931
139MP0003221_abnormal_cardiomyocyte_apopto0.90920195
140MP0003705_abnormal_hypodermis_morpholog0.90497464
141MP0001879_abnormal_lymphatic_vessel0.90214882
142MP0002837_dystrophic_cardiac_calcinosis0.89293835
143MP0001984_abnormal_olfaction0.89098161
144MP0009763_increased_sensitivity_to0.87811107
145MP0008961_abnormal_basal_metabolism0.86388159
146MP0005623_abnormal_meninges_morphology0.86334017
147MP0000015_abnormal_ear_pigmentation0.85584785
148MP0002066_abnormal_motor_capabilities/c0.85565687
149MP0003122_maternal_imprinting0.85130256
150MP0002557_abnormal_social/conspecific_i0.85116013
151MP0002184_abnormal_innervation0.85115358
152MP0008873_increased_physiological_sensi0.84750835
153MP0002272_abnormal_nervous_system0.84561060
154MP0005369_muscle_phenotype0.84560097
155MP0005023_abnormal_wound_healing0.83632479
156MP0002148_abnormal_hypersensitivity_rea0.83274936
157MP0001293_anophthalmia0.82469752
158MP0002752_abnormal_somatic_nervous0.80358483
159MP0005083_abnormal_biliary_tract0.80309597
160MP0010307_abnormal_tumor_latency0.80196676
161MP0005220_abnormal_exocrine_pancreas0.79758715
162MP0009745_abnormal_behavioral_response0.79016305
163MP0005666_abnormal_adipose_tissue0.78795797
164MP0006276_abnormal_autonomic_nervous0.78741352
165MP0002733_abnormal_thermal_nociception0.78072315
166MP0010155_abnormal_intestine_physiology0.77836694
167MP0001970_abnormal_pain_threshold0.77609260
168MP0002089_abnormal_postnatal_growth/wei0.77497548
169MP0003632_abnormal_nervous_system0.76737002
170MP0002095_abnormal_skin_pigmentation0.76621255
171MP0005410_abnormal_fertilization0.76381636
172MP0002734_abnormal_mechanical_nocicepti0.76220512
173MP0000490_abnormal_crypts_of0.75666613
174MP0003631_nervous_system_phenotype0.75599480
175MP0001929_abnormal_gametogenesis0.74567727
176MP0000249_abnormal_blood_vessel0.74267345
177MP0003634_abnormal_glial_cell0.73511662
178MP0000749_muscle_degeneration0.73065243
179MP0002075_abnormal_coat/hair_pigmentati0.72896623
180MP0002210_abnormal_sex_determination0.72341966
181MP0002114_abnormal_axial_skeleton0.71749638
182MP0001348_abnormal_lacrimal_gland0.69695612
183MP0003121_genomic_imprinting0.67898090
184MP0000920_abnormal_myelination0.67406296

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.08880128
2Thrombocytosis (HP:0001894)3.91845785
3Chronic otitis media (HP:0000389)3.89547406
4Peripheral hypomyelination (HP:0007182)3.64682455
5Nasal polyposis (HP:0100582)3.56404409
6Abnormal platelet function (HP:0011869)3.45058208
7Impaired platelet aggregation (HP:0003540)3.45058208
8Hyperglycinemia (HP:0002154)3.43651979
9Abnormal gallbladder physiology (HP:0012438)3.36977406
10Cholecystitis (HP:0001082)3.36977406
11Abnormality of the nasal mucosa (HP:0000433)3.36629884
12Elevated erythrocyte sedimentation rate (HP:0003565)3.29733339
13Prolonged bleeding time (HP:0003010)3.23057253
14Impulsivity (HP:0100710)3.15733028
15Abnormality of the lower motor neuron (HP:0002366)3.14671315
16Exercise-induced myalgia (HP:0003738)3.13595812
17Myokymia (HP:0002411)3.13067012
18Reticulocytosis (HP:0001923)3.10706392
19Hyperacusis (HP:0010780)3.05484321
20Exercise-induced muscle cramps (HP:0003710)3.00810097
21Aplastic anemia (HP:0001915)2.98622800
22Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.95723333
23Ragged-red muscle fibers (HP:0003200)2.92984570
24Abnormality of fatty-acid metabolism (HP:0004359)2.92271963
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86666936
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86666936
27Retinal dysplasia (HP:0007973)2.79120607
28Petechiae (HP:0000967)2.78725979
29Epistaxis (HP:0000421)2.76552309
30Focal motor seizures (HP:0011153)2.75664042
31Ketosis (HP:0001946)2.75363279
32Brushfield spots (HP:0001088)2.74045173
33Ankle clonus (HP:0011448)2.67813780
34Amyotrophic lateral sclerosis (HP:0007354)2.63876005
35Gait imbalance (HP:0002141)2.63515498
36Urinary urgency (HP:0000012)2.59192160
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57478051
38Recurrent bronchitis (HP:0002837)2.50300663
39Congenital primary aphakia (HP:0007707)2.50227670
40Hepatocellular necrosis (HP:0001404)2.49025907
41Polycythemia (HP:0001901)2.45136243
42Medial flaring of the eyebrow (HP:0010747)2.44651768
43Tented upper lip vermilion (HP:0010804)2.42328790
44Increased cerebral lipofuscin (HP:0011813)2.41931935
45High anterior hairline (HP:0009890)2.39526710
46Late onset (HP:0003584)2.37859148
47Hyperammonemia (HP:0001987)2.37208515
48Occipital encephalocele (HP:0002085)2.35556808
49Tetraplegia (HP:0002445)2.35281738
50Abnormality of the corticospinal tract (HP:0002492)2.34350557
51Hypoplasia of the thymus (HP:0000778)2.34060233
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.33413020
53Chest pain (HP:0100749)2.31603788
54Hepatic necrosis (HP:0002605)2.31186161
55IgM deficiency (HP:0002850)2.30648395
56Abnormality of the aortic arch (HP:0012303)2.29405021
57Papilledema (HP:0001085)2.27661864
58Broad distal phalanx of finger (HP:0009836)2.24576869
59Atelectasis (HP:0100750)2.22957050
60Cortical dysplasia (HP:0002539)2.22474147
61Thyroid-stimulating hormone excess (HP:0002925)2.22291957
62Abnormality of the thoracic spine (HP:0100711)2.20833614
63Dysmetric saccades (HP:0000641)2.20822787
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.19287194
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19287194
66Rhabdomyolysis (HP:0003201)2.18936761
67Spastic paraplegia (HP:0001258)2.17734340
68Ketoacidosis (HP:0001993)2.16581279
69Ependymoma (HP:0002888)2.15523450
70Tubulointerstitial nephritis (HP:0001970)2.15032558
71Nephrogenic diabetes insipidus (HP:0009806)2.14441398
72Abnormality of the left ventricular outflow tract (HP:0011103)2.13819370
73Subaortic stenosis (HP:0001682)2.13819370
74Genetic anticipation (HP:0003743)2.13764122
75Abnormal number of erythroid precursors (HP:0012131)2.13154321
76Neonatal respiratory distress (HP:0002643)2.12577377
77Delusions (HP:0000746)2.12228021
78Neoplasm of head and neck (HP:0012288)2.12215964
79Esophageal neoplasm (HP:0100751)2.12215964
80Elfin facies (HP:0004428)2.12103839
81Spastic gait (HP:0002064)2.11187518
82Postural instability (HP:0002172)2.10416600
83EMG: neuropathic changes (HP:0003445)2.10054676
84Gastrointestinal inflammation (HP:0004386)2.09255385
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08535018
86Dicarboxylic aciduria (HP:0003215)2.08535018
87Urinary bladder sphincter dysfunction (HP:0002839)2.07822001
88Lower limb muscle weakness (HP:0007340)2.07471124
89Epiphyseal stippling (HP:0010655)2.07125588
90Myositis (HP:0100614)2.05425152
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.04158345
92Broad foot (HP:0001769)2.03093688
93Adenoma sebaceum (HP:0009720)2.02233528
94Angiofibromas (HP:0010615)2.02233528
95Abnormality of the intervertebral disk (HP:0005108)2.01676956
96Delayed CNS myelination (HP:0002188)2.01644086
97Supranuclear gaze palsy (HP:0000605)2.01461009
98Increased muscle lipid content (HP:0009058)2.00623113
99Abnormality of the fingertips (HP:0001211)2.00512466
100Insomnia (HP:0100785)2.00062708
101Poor coordination (HP:0002370)1.99956028
102Loss of speech (HP:0002371)1.99879960
103Bowel incontinence (HP:0002607)1.99850862
104Recurrent viral infections (HP:0004429)1.99284440
105Menorrhagia (HP:0000132)1.99284164
106Medulloblastoma (HP:0002885)1.97861197
107Abnormality of cells of the erythroid lineage (HP:0012130)1.97506297
108Polygenic inheritance (HP:0010982)1.97409573
109Myopathic facies (HP:0002058)1.96895669
110Pancytopenia (HP:0001876)1.96886951
111Deep venous thrombosis (HP:0002625)1.95171717
112Disinhibition (HP:0000734)1.94866650
113Myoglobinuria (HP:0002913)1.94093513
114Abnormal platelet volume (HP:0011876)1.92732818
115Cellulitis (HP:0100658)1.91674523
116Visual hallucinations (HP:0002367)1.91491641
117Neoplasm of the heart (HP:0100544)1.91310639
118Depression (HP:0000716)1.90917544
119Amaurosis fugax (HP:0100576)1.90743774
120Paraplegia (HP:0010550)1.90180113
121Abnormality of alanine metabolism (HP:0010916)1.89155777
122Hyperalaninemia (HP:0003348)1.89155777
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89155777
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88818180
125Hypoplasia of the brainstem (HP:0002365)1.88750757
126Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88750757
127Type II lissencephaly (HP:0007260)1.88362580
128Abnormality of serine family amino acid metabolism (HP:0010894)1.88202073
129Abnormality of glycine metabolism (HP:0010895)1.88202073
130Hypoplasia of the iris (HP:0007676)1.87723327
131Atrophy/Degeneration involving motor neurons (HP:0007373)1.87485648
132Abnormality of the heme biosynthetic pathway (HP:0010472)1.86332293
133Thoracic kyphosis (HP:0002942)1.86103820
134Purpura (HP:0000979)1.85658048
135Scapular winging (HP:0003691)1.85263670
136Deep palmar crease (HP:0006191)1.83992074
137Large eyes (HP:0001090)1.83966916
138Self-mutilation (HP:0000742)1.83200123
139Abnormal large intestine physiology (HP:0012700)1.82941376
140True hermaphroditism (HP:0010459)1.82640214
141Bronchitis (HP:0012387)1.82504611
142Chronic hepatic failure (HP:0100626)1.82302829
143Hand muscle atrophy (HP:0009130)1.82222856
144Asymmetric septal hypertrophy (HP:0001670)1.81774647
145Steppage gait (HP:0003376)1.81406254
146Prominent nasal bridge (HP:0000426)1.81172509
147Sensorimotor neuropathy (HP:0007141)1.80101161
148Spontaneous hematomas (HP:0007420)1.79147758
149Gonadotropin excess (HP:0000837)1.78746926
150Chronic sinusitis (HP:0011109)1.78367821
151Neuronal loss in central nervous system (HP:0002529)1.77426639
152Cerebellar dysplasia (HP:0007033)1.77388306
153Aggressive behavior (HP:0000718)1.76998011
154Scanning speech (HP:0002168)1.76872689
155Decreased testicular size (HP:0008734)1.76619986
156Lymphangioma (HP:0100764)1.76500055
157Hypercortisolism (HP:0001578)1.76474419
158Focal seizures (HP:0007359)1.75906094
159Abnormality of reticulocytes (HP:0004312)1.74623665
160Abnormality of pyrimidine metabolism (HP:0004353)1.73998387
161Agnosia (HP:0010524)1.73793841
162Increased intramyocellular lipid droplets (HP:0012240)1.73428543
163Inflammation of the large intestine (HP:0002037)1.73424807
164Gonadal dysgenesis (HP:0000133)1.73244280
165Atonic seizures (HP:0010819)1.73015251
166Abnormality of the phalanges of the hallux (HP:0010057)1.72397699
167Broad palm (HP:0001169)1.72364305
168Heterotopia (HP:0002282)1.72331888
169Striae distensae (HP:0001065)1.72161644
170Heterochromia iridis (HP:0001100)1.71776519
171Deformed sella turcica (HP:0002681)1.71498795
172Poor suck (HP:0002033)1.69686357
173Rimmed vacuoles (HP:0003805)1.69455227
174Cardiomegaly (HP:0001640)1.69293393
175Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69242431
176Abnormality of T cell physiology (HP:0011840)1.68720345
177Death in childhood (HP:0003819)1.68465501
178Conjunctival telangiectasia (HP:0000524)1.68031694
179Drooling (HP:0002307)1.67956786
180Open mouth (HP:0000194)1.67945116
181Reticulocytopenia (HP:0001896)1.67915840
182Short 5th finger (HP:0009237)1.67043100
183Renovascular hypertension (HP:0100817)1.66936504
184Spastic diplegia (HP:0001264)1.66338771
185Panhypogammaglobulinemia (HP:0003139)1.66176148
186Shoulder girdle muscle weakness (HP:0003547)1.66172957
187Neonatal onset (HP:0003623)1.66039558
188Increased mean platelet volume (HP:0011877)1.65858560
189Partial agenesis of the corpus callosum (HP:0001338)1.65834429
190Trigonocephaly (HP:0000243)1.65446830
191Specific learning disability (HP:0001328)1.65359038
192Truncal obesity (HP:0001956)1.65212159
193Colitis (HP:0002583)1.64981531
194Gingival bleeding (HP:0000225)1.63722527
195Thrombophlebitis (HP:0004418)1.63535076
196Postaxial foot polydactyly (HP:0001830)1.63414776
197Morphological abnormality of the pyramidal tract (HP:0002062)1.63344374
198Hyperbilirubinemia (HP:0002904)1.62260755
199Neurodegeneration (HP:0002180)1.62225462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.45393918
2MAP4K13.09947356
3TRIB32.97567040
4CDK122.88914317
5PRKD32.69921466
6FLT32.67009381
7CCNB12.57856373
8EPHA42.56037358
9MAP3K112.55734263
10TGFBR12.51869213
11TAOK32.49581094
12MAP3K102.46587641
13KIT2.46186990
14SCYL22.43460474
15EEF2K2.29595982
16BCKDK2.28876370
17MAP2K72.17432829
18MARK12.08865531
19ACVR1B2.08032549
20TYRO31.99989065
21WEE11.92429475
22NME21.90612147
23ERN11.87078255
24CDK191.79251263
25NEK91.77314833
26MAP3K41.75460477
27EIF2AK11.72640624
28ZAP701.71434571
29CSNK1A1L1.71350794
30MAP2K31.64095989
31BTK1.62903470
32DYRK31.55084601
33PAK41.54615126
34CSNK1G31.54007880
35MARK21.53775713
36CSNK1G21.50374720
37RPS6KA41.48085594
38CAMK1G1.47838235
39PBK1.46843328
40MAP3K71.45220319
41TYK21.43773690
42MAP2K41.40391886
43RIPK41.39833531
44KSR21.37146295
45CASK1.36943714
46TBK11.36674543
47PRPF4B1.32779556
48BRSK11.31844136
49SYK1.31500918
50PIM21.28205520
51RAF11.24316496
52MATK1.23725888
53BRD41.23380507
54BCR1.20895458
55NTRK21.20697831
56LRRK21.19748557
57CSF1R1.19287644
58PASK1.16916040
59TESK21.16194776
60EPHB11.15277225
61DAPK11.14627643
62CDC71.14381120
63TXK1.14242971
64PAK61.12501683
65KDR1.11228900
66CAMK41.09146974
67CSNK1G11.08987112
68GRK61.08180078
69TGFBR21.05427213
70MOS1.05347327
71NEK11.05310594
72FGFR41.02774466
73PTK61.00188308
74CDK40.98455213
75RIPK10.96998433
76EIF2AK30.95872076
77TIE10.95168100
78JAK30.90678527
79CDK11A0.88565205
80MAP3K60.88301115
81CAMK1D0.88168353
82UHMK10.87448739
83PINK10.84602368
84OBSCN0.83263848
85ICK0.82857614
86RPS6KA20.82161116
87PIK3CG0.81940371
88CDK50.81833032
89FES0.79194341
90LATS10.78941549
91TNK20.78132039
92ARAF0.77408212
93CDK140.76652445
94MAPK120.76612192
95DYRK20.74325774
96LMTK20.73338123
97ILK0.73243673
98BRAF0.72520075
99SIK10.72185044
100CDK150.71688882
101CDK180.70911593
102NEK20.69931861
103PLK20.68262308
104RPS6KL10.66134970
105RPS6KC10.66134970
106CAMKK10.64552464
107TEC0.64075371
108RPS6KA60.63040748
109RET0.61643475
110MAPK100.61217918
111MAPK130.61116977
112CLK10.60722431
113PTK2B0.60624737
114STK100.57884954
115MAP3K10.56153322
116BUB10.55966419
117PRKD20.55598387
118* MAPK70.55502638
119EPHB20.55120568
120MAP3K120.54806027
121ATR0.54480179
122MINK10.54367652
123CDK60.53949496
124KSR10.53913284
125BMPR1B0.53563948
126DYRK1A0.52762374
127HCK0.50485210
128TRIM280.49537424
129AKT20.49267276
130LCK0.49161450
131CAMKK20.48675839
132SIK20.48220955
133MUSK0.47687114
134CAMK10.47377904
135MAP3K130.47044102
136SIK30.46881894
137MAPKAPK30.46664968
138TESK10.45560151
139DYRK1B0.44362032
140CDK70.44291159
141CDK90.43566558
142IKBKE0.43049586
143NTRK30.43037240
144MAPK90.42928026
145JAK20.42181358
146CDK20.41756619
147SRPK10.41585907
148STK160.41402512
149MAPK40.41243966
150LYN0.40570487
151MAPKAPK20.40258933
152ITK0.40248823
153MAPK110.39145945
154HIPK20.38672588
155PDPK10.36754880
156PLK40.36695483
157MTOR0.36627807
158MAP2K60.36555710
159GSK3B0.36526325
160CDK80.36383217
161MAP3K90.36085003
162SGK30.35095765
163RPS6KA30.33135944
164CHEK10.32160440
165MAPK80.32020301
166BMPR20.31898802

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.94678304
2Mismatch repair_Homo sapiens_hsa034302.93434715
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.91649519
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.57732840
5Base excision repair_Homo sapiens_hsa034102.43251603
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.40827624
7Carbon metabolism_Homo sapiens_hsa012002.02439138
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.00986119
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96626540
10Biosynthesis of amino acids_Homo sapiens_hsa012301.96352642
11Propanoate metabolism_Homo sapiens_hsa006401.92840829
12Fatty acid degradation_Homo sapiens_hsa000711.90693088
13B cell receptor signaling pathway_Homo sapiens_hsa046621.88384533
14Nicotine addiction_Homo sapiens_hsa050331.77285597
15Pentose phosphate pathway_Homo sapiens_hsa000301.76194530
16Long-term potentiation_Homo sapiens_hsa047201.71391044
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66635384
18Shigellosis_Homo sapiens_hsa051311.65046239
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62822731
20GABAergic synapse_Homo sapiens_hsa047271.61533241
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58868849
22Notch signaling pathway_Homo sapiens_hsa043301.55844607
23Peroxisome_Homo sapiens_hsa041461.52446672
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51948779
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51938097
26Primary immunodeficiency_Homo sapiens_hsa053401.50882993
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.49202711
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48955991
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48754875
30One carbon pool by folate_Homo sapiens_hsa006701.47324504
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47213526
32N-Glycan biosynthesis_Homo sapiens_hsa005101.44944494
33Ribosome_Homo sapiens_hsa030101.43266258
34Fatty acid metabolism_Homo sapiens_hsa012121.40923720
35Pyruvate metabolism_Homo sapiens_hsa006201.37396767
36Renal cell carcinoma_Homo sapiens_hsa052111.35773006
37Basal cell carcinoma_Homo sapiens_hsa052171.34064623
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33725560
39Selenocompound metabolism_Homo sapiens_hsa004501.29360215
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.28711118
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26167567
42Chronic myeloid leukemia_Homo sapiens_hsa052201.25324818
43mRNA surveillance pathway_Homo sapiens_hsa030151.25175613
44Arginine and proline metabolism_Homo sapiens_hsa003301.25112909
45Dopaminergic synapse_Homo sapiens_hsa047281.23046943
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22305377
47Fructose and mannose metabolism_Homo sapiens_hsa000511.22213173
48Synaptic vesicle cycle_Homo sapiens_hsa047211.20840005
49Fatty acid elongation_Homo sapiens_hsa000621.19768758
50Morphine addiction_Homo sapiens_hsa050321.19569537
51Homologous recombination_Homo sapiens_hsa034401.19037138
52ErbB signaling pathway_Homo sapiens_hsa040121.15775560
53Circadian entrainment_Homo sapiens_hsa047131.15625680
54Melanogenesis_Homo sapiens_hsa049161.13858538
55Platelet activation_Homo sapiens_hsa046111.13258410
56Sulfur relay system_Homo sapiens_hsa041221.13176879
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11729245
58Dorso-ventral axis formation_Homo sapiens_hsa043201.10742496
59AMPK signaling pathway_Homo sapiens_hsa041521.09980076
60Endometrial cancer_Homo sapiens_hsa052131.09440823
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08413627
62Axon guidance_Homo sapiens_hsa043601.08287456
63Acute myeloid leukemia_Homo sapiens_hsa052211.07694629
64Central carbon metabolism in cancer_Homo sapiens_hsa052301.06029258
65Glutamatergic synapse_Homo sapiens_hsa047241.05912865
66Pyrimidine metabolism_Homo sapiens_hsa002401.03323622
67mTOR signaling pathway_Homo sapiens_hsa041501.02927967
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02136969
69Cholinergic synapse_Homo sapiens_hsa047251.02134545
70Arginine biosynthesis_Homo sapiens_hsa002201.01711354
71Nitrogen metabolism_Homo sapiens_hsa009101.01300632
72Cocaine addiction_Homo sapiens_hsa050301.00888471
73Spliceosome_Homo sapiens_hsa030400.99454376
74Long-term depression_Homo sapiens_hsa047300.98004517
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97353177
76Cell cycle_Homo sapiens_hsa041100.96709731
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96671234
78Osteoclast differentiation_Homo sapiens_hsa043800.95537955
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95148065
80Amphetamine addiction_Homo sapiens_hsa050310.94919530
81Non-small cell lung cancer_Homo sapiens_hsa052230.93326527
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92519922
83Tryptophan metabolism_Homo sapiens_hsa003800.91614202
84T cell receptor signaling pathway_Homo sapiens_hsa046600.90727799
85Choline metabolism in cancer_Homo sapiens_hsa052310.89921358
86Measles_Homo sapiens_hsa051620.89337044
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87438944
88Butanoate metabolism_Homo sapiens_hsa006500.87361725
89Wnt signaling pathway_Homo sapiens_hsa043100.86468667
90VEGF signaling pathway_Homo sapiens_hsa043700.84923209
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84596981
92Inositol phosphate metabolism_Homo sapiens_hsa005620.84438366
93Pancreatic cancer_Homo sapiens_hsa052120.83880751
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83840202
95Leishmaniasis_Homo sapiens_hsa051400.83690347
96Glioma_Homo sapiens_hsa052140.83246053
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82958344
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81053523
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79893311
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79144131
101Hedgehog signaling pathway_Homo sapiens_hsa043400.79030848
102ABC transporters_Homo sapiens_hsa020100.77313208
103Caffeine metabolism_Homo sapiens_hsa002320.75925032
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.75677943
105* MAPK signaling pathway_Homo sapiens_hsa040100.75396460
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75071710
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.75032746
108* Oxytocin signaling pathway_Homo sapiens_hsa049210.74168685
109PPAR signaling pathway_Homo sapiens_hsa033200.73435797
110Proteasome_Homo sapiens_hsa030500.72845423
111Lysine degradation_Homo sapiens_hsa003100.69971862
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69867487
113GnRH signaling pathway_Homo sapiens_hsa049120.69660130
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.68628497
115* Gap junction_Homo sapiens_hsa045400.68386900
116Other glycan degradation_Homo sapiens_hsa005110.67816562
117Folate biosynthesis_Homo sapiens_hsa007900.67624999
118* Neurotrophin signaling pathway_Homo sapiens_hsa047220.67366549
119Hepatitis B_Homo sapiens_hsa051610.66821770
120Endocytosis_Homo sapiens_hsa041440.65916099
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65597530
122Herpes simplex infection_Homo sapiens_hsa051680.64632673
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.64554536
124Antigen processing and presentation_Homo sapiens_hsa046120.64047779
125Glucagon signaling pathway_Homo sapiens_hsa049220.62559597
126Non-homologous end-joining_Homo sapiens_hsa034500.62424573
127Prion diseases_Homo sapiens_hsa050200.60336467
128Type II diabetes mellitus_Homo sapiens_hsa049300.59772802
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59729942
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.59671234
131Colorectal cancer_Homo sapiens_hsa052100.59396570
132Oocyte meiosis_Homo sapiens_hsa041140.58779413
133Viral carcinogenesis_Homo sapiens_hsa052030.58567415
134Alcoholism_Homo sapiens_hsa050340.57728382
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56432490
136Insulin signaling pathway_Homo sapiens_hsa049100.56378049
137Taste transduction_Homo sapiens_hsa047420.55533178
138RNA transport_Homo sapiens_hsa030130.55353837
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54462287
140Estrogen signaling pathway_Homo sapiens_hsa049150.54446076
141Legionellosis_Homo sapiens_hsa051340.53572204
142Apoptosis_Homo sapiens_hsa042100.53132549
143Thyroid cancer_Homo sapiens_hsa052160.52590145
144Phenylalanine metabolism_Homo sapiens_hsa003600.52176323
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52174101
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51764644
147Complement and coagulation cascades_Homo sapiens_hsa046100.50452453
148beta-Alanine metabolism_Homo sapiens_hsa004100.46801700
149HTLV-I infection_Homo sapiens_hsa051660.45448173
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45236037
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.43855205
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43786511
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43585703
154Insulin resistance_Homo sapiens_hsa049310.40491218
155Galactose metabolism_Homo sapiens_hsa000520.39818509
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38797767
157Epstein-Barr virus infection_Homo sapiens_hsa051690.38772007
158RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38522137
159Hematopoietic cell lineage_Homo sapiens_hsa046400.37863134
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37600686
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36991209
162Toxoplasmosis_Homo sapiens_hsa051450.35903805

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