MAP2K6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via telomerase (GO:0007004)9.41234041
2negative regulation of DNA biosynthetic process (GO:2000279)8.89406603
3regulation of telomere maintenance (GO:0032204)8.66849486
4negative regulation of cardiac muscle cell apoptotic process (GO:0010667)8.65012093
5heart trabecula morphogenesis (GO:0061384)8.42939985
6artery development (GO:0060840)7.67356232
7positive regulation of DNA biosynthetic process (GO:2000573)7.03671086
8RNA-dependent DNA replication (GO:0006278)6.95816744
9lymphangiogenesis (GO:0001946)6.93424027
10positive regulation of cellular response to oxidative stress (GO:1900409)6.91234452
11positive regulation of response to oxidative stress (GO:1902884)6.91234452
12trabecula morphogenesis (GO:0061383)6.72434308
13embryonic foregut morphogenesis (GO:0048617)6.28801872
14endothelial cell differentiation (GO:0045446)6.00411319
15cell adhesion mediated by integrin (GO:0033627)5.86237321
16regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.68626389
17interkinetic nuclear migration (GO:0022027)5.61946259
18negative regulation of striated muscle cell apoptotic process (GO:0010664)5.53763962
19organ growth (GO:0035265)5.37106263
20cardiac right ventricle morphogenesis (GO:0003215)5.29082960
21renal system development (GO:0072001)5.22206311
22cell migration in hindbrain (GO:0021535)5.20261300
23hemidesmosome assembly (GO:0031581)4.99011105
24DNA damage response, detection of DNA damage (GO:0042769)4.93239638
25regulation of cardiac muscle cell apoptotic process (GO:0010665)4.87116570
26superoxide anion generation (GO:0042554)4.85928075
27activin receptor signaling pathway (GO:0032924)4.85767597
28response to acidic pH (GO:0010447)4.78982234
29gastrulation with mouth forming second (GO:0001702)4.41526177
30cerebral cortex neuron differentiation (GO:0021895)4.34398542
31secondary heart field specification (GO:0003139)4.33466157
32heart field specification (GO:0003128)4.33466157
33purine nucleobase biosynthetic process (GO:0009113)4.31680012
34DNA unwinding involved in DNA replication (GO:0006268)4.28656718
35protein localization to lysosome (GO:0061462)4.27627435
36protein localization to vacuole (GO:0072665)4.27627435
37brain morphogenesis (GO:0048854)4.12358747
38positive regulation of Rho protein signal transduction (GO:0035025)4.06499221
39activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.05801763
40nucleobase biosynthetic process (GO:0046112)4.05443036
41single strand break repair (GO:0000012)3.96865390
42formation of translation preinitiation complex (GO:0001731)3.95097873
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.93061284
44NADH dehydrogenase complex assembly (GO:0010257)3.93061284
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93061284
46cellular response to pH (GO:0071467)3.90500073
47respiratory burst (GO:0045730)3.88231391
48layer formation in cerebral cortex (GO:0021819)3.84308121
49regulation of striated muscle cell apoptotic process (GO:0010662)3.81669460
50DNA strand elongation involved in DNA replication (GO:0006271)3.79290977
51kinetochore organization (GO:0051383)3.74901416
52regulation of protein heterodimerization activity (GO:0043497)3.73923849
53kinetochore assembly (GO:0051382)3.71932626
54DNA strand renaturation (GO:0000733)3.71119125
55mitotic sister chromatid cohesion (GO:0007064)3.70063975
56histone-serine phosphorylation (GO:0035404)3.69256766
57negative regulation of protein localization to cell surface (GO:2000009)3.67812423
58somatic diversification of immune receptors via somatic mutation (GO:0002566)3.67245958
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.67245958
60regulation of smooth muscle cell differentiation (GO:0051150)3.62435504
61IMP biosynthetic process (GO:0006188)3.62410099
62telomere maintenance via semi-conservative replication (GO:0032201)3.61966493
63DNA strand elongation (GO:0022616)3.61653097
64DNA replication initiation (GO:0006270)3.61414298
65paraxial mesoderm development (GO:0048339)3.61040571
66histone H2A acetylation (GO:0043968)3.57060750
67DNA replication checkpoint (GO:0000076)3.44204980
68DNA double-strand break processing (GO:0000729)3.43432670
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.39486621
70mitotic recombination (GO:0006312)3.37889657
71response to hyperoxia (GO:0055093)3.37778965
72response to increased oxygen levels (GO:0036296)3.37778965
73regulation of DNA biosynthetic process (GO:2000278)3.35820489
74viral mRNA export from host cell nucleus (GO:0046784)3.34051848
75mitotic metaphase plate congression (GO:0007080)3.33181130
76hindbrain development (GO:0030902)3.33005606
77ventricular cardiac muscle cell development (GO:0055015)3.32835028
78protein polyglutamylation (GO:0018095)3.32600070
79filopodium assembly (GO:0046847)3.32255899
80mismatch repair (GO:0006298)3.27287815
81cell proliferation in forebrain (GO:0021846)3.27252165
82CENP-A containing nucleosome assembly (GO:0034080)3.27173513
83pancreas development (GO:0031016)3.26673344
84IMP metabolic process (GO:0046040)3.26559077
85carnitine shuttle (GO:0006853)3.25397436
86heterochromatin organization (GO:0070828)3.25213226
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20545642
88negative regulation of RNA splicing (GO:0033119)3.19625277
89intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.17972813
90maturation of 5.8S rRNA (GO:0000460)3.16627526
91metaphase plate congression (GO:0051310)3.16205506
92nucleus localization (GO:0051647)3.15133976
93positive regulation of TOR signaling (GO:0032008)3.12687720
94telomere maintenance via recombination (GO:0000722)3.12662282
95midgut development (GO:0007494)3.12281600
96type B pancreatic cell development (GO:0003323)3.11063086
97mitotic spindle assembly checkpoint (GO:0007094)3.09870391
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.09281646
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09281646
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09281646
101negative regulation of sister chromatid segregation (GO:0033046)3.09281646
102negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.09125679
103spindle assembly checkpoint (GO:0071173)3.09120545
104negative regulation of chromosome segregation (GO:0051985)3.07797191
105regulation of nuclear cell cycle DNA replication (GO:0033262)3.07677218
106chromatin remodeling at centromere (GO:0031055)3.07515300
107pseudouridine synthesis (GO:0001522)3.07443764
108positive regulation of cardiac muscle cell proliferation (GO:0060045)3.05839760
109RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03160430
110mRNA splicing, via spliceosome (GO:0000398)3.03160430
111negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.02074077
112telomere maintenance via telomere lengthening (GO:0010833)3.02046088
113nodal signaling pathway (GO:0038092)3.01747449
114RNA splicing, via transesterification reactions (GO:0000375)3.01498427
115replication fork processing (GO:0031297)3.01023613
116DNA replication-independent nucleosome organization (GO:0034724)2.99825616
117DNA replication-independent nucleosome assembly (GO:0006336)2.99825616
118positive regulation of cardiac muscle tissue growth (GO:0055023)2.98963646
119DNA topological change (GO:0006265)2.97905029
120insulin secretion (GO:0030073)2.97504466
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95858066
122viral genome replication (GO:0019079)2.94461979
123heart valve formation (GO:0003188)2.93810090
124establishment of chromosome localization (GO:0051303)2.92963781
125exogenous drug catabolic process (GO:0042738)2.92611931
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.91741585
127positive regulation of small GTPase mediated signal transduction (GO:0051057)2.90572547
128specification of organ identity (GO:0010092)2.89959258
129cytoplasmic sequestering of transcription factor (GO:0042994)2.89331490
130mitotic nuclear envelope disassembly (GO:0007077)2.86772038
131outer ear morphogenesis (GO:0042473)2.86676183
132positive regulation vascular endothelial growth factor production (GO:0010575)2.86318581
133negative regulation of DNA replication (GO:0008156)2.84911736
134protein K11-linked ubiquitination (GO:0070979)2.84570729
135regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84570453
136nucleotide transmembrane transport (GO:1901679)2.84335029
137regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.84233311
138negative regulation of mRNA processing (GO:0050686)2.83696013
139G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.82359088
140spindle checkpoint (GO:0031577)2.81655784
141C4-dicarboxylate transport (GO:0015740)2.80160596
142DNA replication-dependent nucleosome assembly (GO:0006335)2.79942064
143DNA replication-dependent nucleosome organization (GO:0034723)2.79942064
144DNA geometric change (GO:0032392)2.79569068
145sister chromatid segregation (GO:0000819)2.79512295
146ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.78840972
147DNA-dependent DNA replication (GO:0006261)2.78421721
148DNA duplex unwinding (GO:0032508)2.77958541
149mitotic spindle checkpoint (GO:0071174)2.75044091
150regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74759305
151spliceosomal snRNP assembly (GO:0000387)2.72766297
152intra-S DNA damage checkpoint (GO:0031573)2.72597283
153deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72448906
154regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72001170
155nuclear pore organization (GO:0006999)2.71756948
156transcription-coupled nucleotide-excision repair (GO:0006283)2.70201221
157ribosome biogenesis (GO:0042254)2.69373391
158DNA demethylation (GO:0080111)2.68641290
159proteasome assembly (GO:0043248)2.68116332
160positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.66366142
161regulation of sister chromatid segregation (GO:0033045)2.65260152
162regulation of mitotic sister chromatid separation (GO:0010965)2.65260152
163regulation of mitotic sister chromatid segregation (GO:0033047)2.65260152
164type B pancreatic cell proliferation (GO:0044342)2.63888777
165protein complex biogenesis (GO:0070271)2.63077530
166peptidyl-arginine omega-N-methylation (GO:0035247)2.62629173
167regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.62515499
168endocrine process (GO:0050886)2.62515499
169regulation of systemic arterial blood pressure by hormone (GO:0001990)2.62515499
170regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62055406
171negative regulation of mitosis (GO:0045839)2.61949699
172negative regulation of muscle cell apoptotic process (GO:0010656)2.61876790
173base-excision repair (GO:0006284)2.60785251
174glycerophospholipid catabolic process (GO:0046475)2.60749748
175fatty acid transmembrane transport (GO:1902001)2.60404462
176mitotic sister chromatid segregation (GO:0000070)2.59297137
177tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58563602
178RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58563602
179regulation of DNA damage checkpoint (GO:2000001)2.58453960
180maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58178781
181DNA catabolic process, exonucleolytic (GO:0000738)2.57923757
182tryptophan catabolic process (GO:0006569)2.57912739
183indole-containing compound catabolic process (GO:0042436)2.57912739
184indolalkylamine catabolic process (GO:0046218)2.57912739
185regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.57585854
186positive regulation of heart growth (GO:0060421)2.56738942
187neuron projection extension involved in neuron projection guidance (GO:1902284)2.56669894
188axon extension involved in axon guidance (GO:0048846)2.56669894
189protein localization to kinetochore (GO:0034501)2.56303931
190regulation of telomere maintenance via telomerase (GO:0032210)16.7850483
191negative regulation of telomerase activity (GO:0051974)16.1994826
192negative regulation of telomere maintenance (GO:0032205)14.0155045
193regulation of helicase activity (GO:0051095)12.9827135
194regulation of telomerase activity (GO:0051972)10.6041601
195ventricular trabecula myocardium morphogenesis (GO:0003222)10.2846748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40497331
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.27665538
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.07549860
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.62693487
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.24318095
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99206227
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.92191869
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.50517517
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.32320607
10GBX2_23144817_ChIP-Seq_PC3_Human3.23502989
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.85462100
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.81302292
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72918419
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69486905
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64117972
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61061080
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49463812
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48752485
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46349809
20YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35689758
21CIITA_25753668_ChIP-Seq_RAJI_Human2.34180874
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34178871
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.32431059
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30118009
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.28326778
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.27737795
27SOX2_18555785_ChIP-Seq_MESCs_Mouse2.20717314
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20343364
29AR_21909140_ChIP-Seq_LNCAP_Human2.16518570
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.15352638
31* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.10165221
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07023003
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05205811
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse10.5814126
35FOXP3_21729870_ChIP-Seq_TREG_Human1.94767457
36TAF15_26573619_Chip-Seq_HEK293_Human1.90109871
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86249931
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85286906
39XRN2_22483619_ChIP-Seq_HELA_Human1.84184123
40* EST1_17652178_ChIP-ChIP_JURKAT_Human1.83957672
41SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.80884175
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79112208
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.78818944
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78408727
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.76922737
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.76237101
47* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74436203
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70930847
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.67619810
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67042330
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66985938
52* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65886832
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64894562
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.64627152
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63143410
56TTF2_22483619_ChIP-Seq_HELA_Human1.62432248
57* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61808750
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57153032
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56383903
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.54491261
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.52820141
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51196994
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50926942
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.50520207
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49704371
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48436645
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48419812
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47109982
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45713350
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44163535
71MYC_22102868_ChIP-Seq_BL_Human1.43457242
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.43052310
73EWS_26573619_Chip-Seq_HEK293_Human1.42240168
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.41780277
75AR_21572438_ChIP-Seq_LNCaP_Human1.41598252
76VDR_23849224_ChIP-Seq_CD4+_Human1.39105139
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.37609686
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35501941
79TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35261135
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.35127395
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34289275
82GABP_19822575_ChIP-Seq_HepG2_Human1.33756821
83ZNF274_21170338_ChIP-Seq_K562_Hela1.33425566
84* STAT3_23295773_ChIP-Seq_U87_Human1.32721931
85DCP1A_22483619_ChIP-Seq_HELA_Human1.32576979
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31936335
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31227078
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30884067
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.30206529
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29769266
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.29149167
92TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28693147
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27970024
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26616262
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25198987
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25077470
97CBP_20019798_ChIP-Seq_JUKART_Human1.19678440
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19678440
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18728304
100REST_21632747_ChIP-Seq_MESCs_Mouse1.18250080
101ER_23166858_ChIP-Seq_MCF-7_Human1.18235901
102ELK1_19687146_ChIP-ChIP_HELA_Human1.16838113
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15120268
104SMAD4_21799915_ChIP-Seq_A2780_Human1.11373060
105EZH2_22144423_ChIP-Seq_EOC_Human1.10956861
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10861870
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10449093
108* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09730129
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09185263
110RUNX2_22187159_ChIP-Seq_PCA_Human1.08533162
111* SMAD3_21741376_ChIP-Seq_EPCs_Human1.08467287
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07904988
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07130819
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06758783
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06558761
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06519080
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05874045
118TRIM28_21343339_ChIP-Seq_HEK293_Human1.05233759
119FUS_26573619_Chip-Seq_HEK293_Human1.04998323
120ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03769434
121KDM5A_27292631_Chip-Seq_BREAST_Human1.03304428
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02753310
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01868152
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00382019
125TCF4_22108803_ChIP-Seq_LS180_Human1.00232137
126TCF4_23295773_ChIP-Seq_U87_Human0.99609267
127LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99521317
128* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99503682
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99212945
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98462294
131MYC_18940864_ChIP-ChIP_HL60_Human0.96406225
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95882027
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95765642
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92917822
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.92678296
136IRF1_19129219_ChIP-ChIP_H3396_Human0.92227618
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.91450203
138SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91178181
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90659058
140POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90572714
141* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89583435
142TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88990774
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.86562065
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86077630
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85528770
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84953640
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84469249
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82716522
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82570973
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82497445
151SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82407002
152* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82340039
153TCF4_18268006_ChIP-ChIP_LS174T_Human0.82301616
154RXR_22108803_ChIP-Seq_LS180_Human0.81615756
155* TP53_16413492_ChIP-PET_HCT116_Human0.81193156
156ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80942136
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80896113
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.80111900
159AR_25329375_ChIP-Seq_VCAP_Human0.80108714
160EED_16625203_ChIP-ChIP_MESCs_Mouse0.79538280
161* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79301214
162SOX9_26525672_Chip-Seq_HEART_Mouse0.78097576
163CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77238176
164EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75488089
165* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75092375
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.72859534
167TP53_22573176_ChIP-Seq_HFKS_Human0.72181097
168* FLI1_21867929_ChIP-Seq_TH2_Mouse0.71950139
169IRF8_21731497_ChIP-ChIP_J774_Mouse0.71760266
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71557129
171POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71557129
172P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.70686702
173* P300_19829295_ChIP-Seq_ESCs_Human0.70134498
174E2F1_18555785_Chip-Seq_ESCs_Mouse0.70055741
175* SOX2_21211035_ChIP-Seq_LN229_Human0.69771908
176JUN_21703547_ChIP-Seq_K562_Human0.69080055
177FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67975684
178RNF2_27304074_Chip-Seq_NSC_Mouse0.67227117
179TBL1_22424771_ChIP-Seq_293T_Human0.67016782
180MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.66727957
181KLF5_20875108_ChIP-Seq_MESCs_Mouse0.66200889
182* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.64820489
183* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.63708950
184TBX3_20139965_ChIP-Seq_MESCs_Mouse0.63503281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia5.99281129
2MP0002163_abnormal_gland_morphology5.66476486
3MP0003880_abnormal_central_pattern4.55030555
4MP0006292_abnormal_olfactory_placode4.23067832
5MP0002127_abnormal_cardiovascular_syste3.68974723
6MP0008775_abnormal_heart_ventricle3.31766038
7MP0006276_abnormal_autonomic_nervous3.24152509
8MP0005379_endocrine/exocrine_gland_phen3.15333076
9MP0005595_abnormal_vascular_smooth3.11807706
10MP0002102_abnormal_ear_morphology3.09512253
11MP0003111_abnormal_nucleus_morphology3.01961873
12MP0003123_paternal_imprinting2.95557728
13MP0010030_abnormal_orbit_morphology2.94399491
14MP0004272_abnormal_basement_membrane2.81583127
15MP0003077_abnormal_cell_cycle2.74625523
16MP0008057_abnormal_DNA_replication2.73663806
17MP0009697_abnormal_copulation2.70666547
18MP0010094_abnormal_chromosome_stability2.69430435
19MP0008007_abnormal_cellular_replicative2.68029198
20MP0000537_abnormal_urethra_morphology2.57303425
21MP0003121_genomic_imprinting2.48097618
22MP0003122_maternal_imprinting2.36396406
23MP0008058_abnormal_DNA_repair2.34840289
24MP0003567_abnormal_fetal_cardiomyocyte2.30146499
25MP0003938_abnormal_ear_development2.27628288
26MP0000749_muscle_degeneration2.25570948
27MP0003890_abnormal_embryonic-extraembry2.17114247
28MP0003693_abnormal_embryo_hatching2.13861122
29MP0004145_abnormal_muscle_electrophysio2.08292256
30MP0000647_abnormal_sebaceous_gland2.06192079
31MP0000566_synostosis1.98703445
32MP0004957_abnormal_blastocyst_morpholog1.98424429
33MP0000678_abnormal_parathyroid_gland1.97164443
34MP0003646_muscle_fatigue1.91767778
35MP0002249_abnormal_larynx_morphology1.90328830
36MP0004147_increased_porphyrin_level1.84429757
37MP0002734_abnormal_mechanical_nocicepti1.81873550
38MP0004883_abnormal_blood_vessel1.81804387
39MP0002938_white_spotting1.74606623
40MP0005646_abnormal_pituitary_gland1.71864647
41MP0001293_anophthalmia1.70638938
42MP0008875_abnormal_xenobiotic_pharmacok1.66451062
43MP0003942_abnormal_urinary_system1.66122283
44MP0003119_abnormal_digestive_system1.55575006
45MP0009745_abnormal_behavioral_response1.55401683
46MP0003941_abnormal_skin_development1.53809133
47MP0008932_abnormal_embryonic_tissue1.53761125
48MP0000049_abnormal_middle_ear1.51644773
49MP0005330_cardiomyopathy1.48397972
50MP0009384_cardiac_valve_regurgitation1.47731130
51MP0003937_abnormal_limbs/digits/tail_de1.47676826
52MP0001286_abnormal_eye_development1.46527379
53MP0003385_abnormal_body_wall1.46312939
54MP0002168_other_aberrant_phenotype1.44516435
55MP0005620_abnormal_muscle_contractility1.43605718
56MP0001672_abnormal_embryogenesis/_devel1.43042715
57MP0005380_embryogenesis_phenotype1.43042715
58MP0003806_abnormal_nucleotide_metabolis1.42564043
59MP0002089_abnormal_postnatal_growth/wei1.41612160
60MP0002653_abnormal_ependyma_morphology1.41479420
61MP0003195_calcinosis1.40287974
62MP0005084_abnormal_gallbladder_morpholo1.39990848
63MP0002972_abnormal_cardiac_muscle1.38719432
64MP0003448_altered_tumor_morphology1.37725381
65MP0002085_abnormal_embryonic_tissue1.36803103
66MP0003115_abnormal_respiratory_system1.33388625
67MP0005360_urolithiasis1.33030091
68MP0001485_abnormal_pinna_reflex1.32503083
69MP0002233_abnormal_nose_morphology1.30026062
70MP0003861_abnormal_nervous_system1.29477154
71MP0008789_abnormal_olfactory_epithelium1.26764941
72MP0003787_abnormal_imprinting1.26424331
73MP0009053_abnormal_anal_canal1.24193633
74MP0000778_abnormal_nervous_system1.24180405
75MP0002932_abnormal_joint_morphology1.23559184
76MP0001697_abnormal_embryo_size1.23471684
77MP0003935_abnormal_craniofacial_develop1.22505818
78MP0002088_abnormal_embryonic_growth/wei1.22362531
79MP0002282_abnormal_trachea_morphology1.22315653
80MP0003984_embryonic_growth_retardation1.22084439
81MP0004808_abnormal_hematopoietic_stem1.21554645
82MP0001730_embryonic_growth_arrest1.21067334
83MP0000230_abnormal_systemic_arterial1.19985195
84MP0002084_abnormal_developmental_patter1.19919188
85MP0005248_abnormal_Harderian_gland1.19846763
86MP0009672_abnormal_birth_weight1.19778005
87MP0004133_heterotaxia1.19603854
88MP0002876_abnormal_thyroid_physiology1.19243441
89MP0000534_abnormal_ureter_morphology1.16928844
90MP0009278_abnormal_bone_marrow1.16685585
91MP0002751_abnormal_autonomic_nervous1.16362290
92MP0005394_taste/olfaction_phenotype1.15110996
93MP0005499_abnormal_olfactory_system1.15110996
94MP0008874_decreased_physiological_sensi1.14829188
95MP0002332_abnormal_exercise_endurance1.14660204
96MP0002086_abnormal_extraembryonic_tissu1.13416856
97MP0003755_abnormal_palate_morphology1.12847674
98MP0000343_altered_response_to1.12004121
99MP0000350_abnormal_cell_proliferation1.12001996
100MP0008995_early_reproductive_senescence1.11340938
101MP0002064_seizures1.11219629
102MP0004484_altered_response_of1.10851516
103MP0003943_abnormal_hepatobiliary_system1.07336008
104MP0000249_abnormal_blood_vessel1.05833692
105MP0004233_abnormal_muscle_weight1.05081273
106MP0010630_abnormal_cardiac_muscle1.03526329
107MP0003315_abnormal_perineum_morphology1.03139182
108MP0009250_abnormal_appendicular_skeleto1.01177366
109MP0001529_abnormal_vocalization1.01112773
110MP0002095_abnormal_skin_pigmentation1.00623984
111MP0004811_abnormal_neuron_physiology1.00027692
112MP0003136_yellow_coat_color0.98375490
113MP0002139_abnormal_hepatobiliary_system0.98375056
114MP0002111_abnormal_tail_morphology0.96801797
115MP0001915_intracranial_hemorrhage0.95198500
116MP0005195_abnormal_posterior_eye0.94547294
117MP0002116_abnormal_craniofacial_bone0.93765767
118MP0000015_abnormal_ear_pigmentation0.93615394
119MP0003283_abnormal_digestive_organ0.93412322
120MP0005085_abnormal_gallbladder_physiolo0.93042955
121MP0005187_abnormal_penis_morphology0.91909649
122MP0005551_abnormal_eye_electrophysiolog0.91510336
123MP0001544_abnormal_cardiovascular_syste0.90806818
124MP0005385_cardiovascular_system_phenoty0.90806818
125MP0005197_abnormal_uvea_morphology0.90700283
126MP0000920_abnormal_myelination0.90648792
127MP0002092_abnormal_eye_morphology0.90610969
128MP0006072_abnormal_retinal_apoptosis0.89880368
129MP0004197_abnormal_fetal_growth/weight/0.89212799
130MP0002080_prenatal_lethality0.88617664
131MP0002114_abnormal_axial_skeleton0.87839983
132MP0000428_abnormal_craniofacial_morphol0.86724171
133MP0000427_abnormal_hair_cycle0.85789192
134MP0005171_absent_coat_pigmentation0.84248040
135MP0000631_abnormal_neuroendocrine_gland0.83957548
136MP0003221_abnormal_cardiomyocyte_apopto0.83911911
137MP0002075_abnormal_coat/hair_pigmentati0.83819538
138MP0005266_abnormal_metabolism0.83746745
139MP0003635_abnormal_synaptic_transmissio0.83655506
140MP0001849_ear_inflammation0.82913815
141MP0005365_abnormal_bile_salt0.82126932
142MP0002736_abnormal_nociception_after0.81894363
143MP0003786_premature_aging0.81560592
144MP0010368_abnormal_lymphatic_system0.81318106
145MP0002557_abnormal_social/conspecific_i0.81216610
146MP0001324_abnormal_eye_pigmentation0.80861021
147MP0002697_abnormal_eye_size0.79707873
148MP0004924_abnormal_behavior0.78870848
149MP0005386_behavior/neurological_phenoty0.78870848
150MP0000383_abnormal_hair_follicle0.78073820
151MP0002396_abnormal_hematopoietic_system0.77970074
152MP0005319_abnormal_enzyme/_coenzyme0.75138878
153MP0002081_perinatal_lethality0.75020324
154MP0000767_abnormal_smooth_muscle0.74255068
155MP0003303_peritoneal_inflammation0.74140284
156MP0002109_abnormal_limb_morphology0.70674122
157MP0002184_abnormal_innervation0.69719200
158MP0001968_abnormal_touch/_nociception0.68587150
159MP0002063_abnormal_learning/memory/cond0.66657476
160MP0005395_other_phenotype0.63735496
161MP0001963_abnormal_hearing_physiology0.63586443
162MP0000432_abnormal_head_morphology0.63366093
163MP0000465_gastrointestinal_hemorrhage0.60539611
164MP0005448_abnormal_energy_balance0.57740040
165MP0004043_abnormal_pH_regulation0.56510368
166MP0006138_congestive_heart_failure0.56127782
167MP0003948_abnormal_gas_homeostasis0.55375564
168MP0003137_abnormal_impulse_conducting0.54568670
169MP0010352_gastrointestinal_tract_polyps0.53521223
170MP0000955_abnormal_spinal_cord0.53087046
171MP0001919_abnormal_reproductive_system0.50519274

Predicted human phenotypes

RankGene SetZ-score
1Aplasia cutis congenita (HP:0001057)8.63320890
2Increased serum pyruvate (HP:0003542)7.55093907
3Gastrointestinal atresia (HP:0002589)7.05156389
4Abnormality of glycolysis (HP:0004366)6.45982764
5Increased connective tissue (HP:0009025)6.30208945
6Ureteral stenosis (HP:0000071)5.72022937
7Milia (HP:0001056)5.41184963
8Ureteral obstruction (HP:0006000)5.32513653
9Atrophic scars (HP:0001075)4.95397325
10Fragile skin (HP:0001030)4.90751393
11Pterygium (HP:0001059)4.83920496
12Ragged-red muscle fibers (HP:0003200)4.49115636
13Curly hair (HP:0002212)4.00479059
14Chronic hepatic failure (HP:0100626)3.78309102
15Tetraplegia (HP:0002445)3.76314165
16Hypokinesia (HP:0002375)3.75911415
17Ectropion (HP:0000656)3.75701717
18Atrioventricular canal defect (HP:0006695)3.63976760
19Freckling (HP:0001480)3.54499795
20Birth length less than 3rd percentile (HP:0003561)3.52404704
21Melanoma (HP:0002861)3.50888925
22Atonic seizures (HP:0010819)3.47830101
23Colon cancer (HP:0003003)3.30840477
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20330361
25Medulloblastoma (HP:0002885)3.12642883
26Amblyopia (HP:0000646)3.08420652
27Abnormal lung lobation (HP:0002101)3.06778776
28Neoplasm of the pancreas (HP:0002894)2.96889376
29Blue irides (HP:0000635)2.92777900
30Chromsome breakage (HP:0040012)2.91068062
31Shawl scrotum (HP:0000049)2.90479968
32Hepatocellular necrosis (HP:0001404)2.88170746
33Patellar aplasia (HP:0006443)2.85623027
34Papillary thyroid carcinoma (HP:0002895)2.81101726
35Breast hypoplasia (HP:0003187)2.78492436
36Molar tooth sign on MRI (HP:0002419)2.75636149
37Abnormality of midbrain morphology (HP:0002418)2.75636149
38Aplasia/Hypoplasia of the patella (HP:0006498)2.71930959
39Volvulus (HP:0002580)2.71689218
40Shoulder girdle muscle weakness (HP:0003547)2.71122959
41Selective tooth agenesis (HP:0001592)2.71105231
42Abnormality of the ileum (HP:0001549)2.70888787
43Anophthalmia (HP:0000528)2.68657202
44Meckel diverticulum (HP:0002245)2.67960469
45Short 4th metacarpal (HP:0010044)2.66044066
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66044066
47Retinopathy (HP:0000488)2.58136838
48Abnormal number of incisors (HP:0011064)2.57752564
49Hypoplasia of dental enamel (HP:0006297)2.52130941
50Type 2 muscle fiber atrophy (HP:0003554)2.50954561
51Supernumerary spleens (HP:0009799)2.49776092
52Abnormality of the prostate (HP:0008775)2.48499939
53Renal duplication (HP:0000075)2.46865127
54Broad alveolar ridges (HP:0000187)2.45057117
55Nephroblastoma (Wilms tumor) (HP:0002667)2.44554651
56Increased nuchal translucency (HP:0010880)2.41060095
57Status epilepticus (HP:0002133)2.40467742
58High anterior hairline (HP:0009890)2.36043228
59Cystic hygroma (HP:0000476)2.34566706
60Hyperventilation (HP:0002883)2.31842996
61Nephronophthisis (HP:0000090)2.30159516
62Increased CSF lactate (HP:0002490)2.29904733
63Oral leukoplakia (HP:0002745)2.27029260
64Embryonal renal neoplasm (HP:0011794)2.25891423
65Abnormality of the 4th metacarpal (HP:0010012)2.24454953
66Hepatoblastoma (HP:0002884)2.24284485
67Muscle fiber atrophy (HP:0100295)2.23893611
68Large earlobe (HP:0009748)2.22533720
69Abnormality of the lower motor neuron (HP:0002366)2.21420023
70Broad metatarsal (HP:0001783)2.21190734
71Duodenal stenosis (HP:0100867)2.20913171
72Small intestinal stenosis (HP:0012848)2.20913171
73Aplasia/Hypoplasia of the sternum (HP:0006714)2.20650886
74Abnormality of the preputium (HP:0100587)2.16091127
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.15883836
76Abnormality of the labia minora (HP:0012880)2.14902903
77Intestinal atresia (HP:0011100)2.14791120
78Hepatic necrosis (HP:0002605)2.13395051
79Septo-optic dysplasia (HP:0100842)2.10238802
80Asymmetry of the thorax (HP:0001555)2.09423806
81Diminished movement (HP:0002374)2.09311681
82Fibular hypoplasia (HP:0003038)2.07674317
83Clumsiness (HP:0002312)2.04481849
84Renal hypoplasia (HP:0000089)2.02551983
85Ependymoma (HP:0002888)2.01211578
86Fibular aplasia (HP:0002990)2.00541837
87Esophageal atresia (HP:0002032)10.8728687
88Abnormality of the aortic arch (HP:0012303)10.0300164
89Aplastic anemia (HP:0001915)1.99355426
90Rimmed vacuoles (HP:0003805)1.99192059
91Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98934784
92Embryonal neoplasm (HP:0002898)1.98884985
93Optic nerve coloboma (HP:0000588)1.98780920
94Ectopic kidney (HP:0000086)1.98659121
95Diastasis recti (HP:0001540)1.96182615
96Abnormality of the duodenum (HP:0002246)1.95341293
97Preauricular pit (HP:0004467)1.94946326
98Periauricular skin pits (HP:0100277)1.94946326
99Hip dysplasia (HP:0001385)1.94273993
100Dialeptic seizures (HP:0011146)1.93104819
101Short middle phalanx of finger (HP:0005819)1.92949153
102Neoplasm of the liver (HP:0002896)1.91622816
103Intrahepatic cholestasis (HP:0001406)1.91464194
104Facial cleft (HP:0002006)1.90405746
105Premature graying of hair (HP:0002216)1.89851995
106CNS demyelination (HP:0007305)1.89295704
107Broad palm (HP:0001169)1.88325291
108Trigonocephaly (HP:0000243)1.87899809
109Atresia of the external auditory canal (HP:0000413)1.87532051
110Aplasia/Hypoplasia of the fibula (HP:0006492)1.87124366
111Syringomyelia (HP:0003396)1.86463207
112Spinal cord lesions (HP:0100561)1.86463207
113Difficulty running (HP:0009046)1.86324413
114Agnosia (HP:0010524)1.85104627
115Focal seizures (HP:0007359)1.84228716
116Cerebral palsy (HP:0100021)1.84056009
117Fair hair (HP:0002286)1.83801588
118Redundant skin (HP:0001582)1.82622096
119Rhabdomyosarcoma (HP:0002859)1.82038865
120Glioma (HP:0009733)1.81896311
121Abnormality of the renal collecting system (HP:0004742)1.80103819
122Short palpebral fissure (HP:0012745)1.79191032
123Protruding tongue (HP:0010808)1.78024007
124Facial hemangioma (HP:0000329)1.77422537
125Neoplasm of the colon (HP:0100273)1.76115933
126Supernumerary bones of the axial skeleton (HP:0009144)1.75286516
127Abnormality of male internal genitalia (HP:0000022)1.75229876
128Myelodysplasia (HP:0002863)1.73304071
129Abnormality of the carotid arteries (HP:0005344)1.72740469
130Synostosis involving the elbow (HP:0003938)1.72674436
131Humeroradial synostosis (HP:0003041)1.72674436
132Abnormality of the intervertebral disk (HP:0005108)1.72407363
133Abnormality of pyrimidine metabolism (HP:0004353)1.71989706
134Inability to walk (HP:0002540)1.70579435
135Optic nerve hypoplasia (HP:0000609)1.70494750
136Supernumerary ribs (HP:0005815)1.69533068
137Oligodactyly (HP:0012165)1.68790118
138Stenosis of the external auditory canal (HP:0000402)1.68148555
139Pelvic girdle muscle weakness (HP:0003749)1.67515623
140Skull defect (HP:0001362)1.67513658
141Fasciculations (HP:0002380)1.67302049
142Chorioretinal atrophy (HP:0000533)1.67125195
143Absence seizures (HP:0002121)1.67040840
144Anonychia (HP:0001798)1.66734760
145Nemaline bodies (HP:0003798)1.65576040
146Radial bowing (HP:0002986)1.64888052
147Morphological abnormality of the middle ear (HP:0008609)1.64848681
148Abnormality of the astrocytes (HP:0100707)1.64809874
149Astrocytoma (HP:0009592)1.64809874
150Hypoplastic labia majora (HP:0000059)1.63621732
151Delayed puberty (HP:0000823)1.62216023
152Abnormality of chromosome stability (HP:0003220)1.62137837
153Single transverse palmar crease (HP:0000954)1.60824096
154Chorioretinal coloboma (HP:0000567)1.60700862
155Abnormality of the renal medulla (HP:0100957)1.60661665
156Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.60281720
157Neoplasm of the adrenal cortex (HP:0100641)1.59791024
158Cellular immunodeficiency (HP:0005374)1.59339882
159Hemivertebrae (HP:0002937)1.59286996
160Renal dysplasia (HP:0000110)1.57924072
161Neoplasm of striated muscle (HP:0009728)1.56828082
162Bilateral microphthalmos (HP:0007633)1.56026083
163Thyroid carcinoma (HP:0002890)1.55858564
164Thickened calvaria (HP:0002684)1.55297162
165Recurrent corneal erosions (HP:0000495)1.55225513
166Abnormality of the alveolar ridges (HP:0006477)1.54643242
167Cutis marmorata (HP:0000965)1.53840630
168Abnormality of the musculature of the pelvis (HP:0001469)1.51011567
169Abnormality of the hip-girdle musculature (HP:0001445)1.51011567
170Aplasia involving bones of the upper limbs (HP:0009823)1.50499092
171Aplasia of the phalanges of the hand (HP:0009802)1.50499092
172Aplasia involving bones of the extremities (HP:0009825)1.50499092
173Heterochromia iridis (HP:0001100)1.48733111
174Death in infancy (HP:0001522)1.48474309
175Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47947445
176Exotropia (HP:0000577)1.46779326
177Synostosis of carpal bones (HP:0005048)1.39443645
178Hip contracture (HP:0003273)1.39051954
179Abnormality of the middle phalanges of the hand (HP:0009833)1.38902259
180Stomach cancer (HP:0012126)1.37846203
181Asplenia (HP:0001746)1.36609034
182Symphalangism affecting the phalanges of the hand (HP:0009773)1.36098435
183Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.35884516
184Aplasia/Hypoplasia of the fovea (HP:0008060)1.35650813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K26.67419947
2SIK25.53325863
3NME13.73211858
4BUB13.39484493
5RIPK13.21491722
6WEE13.00488882
7TSSK62.98208495
8MKNK12.63914339
9MKNK22.53875406
10CCNB12.51976523
11SRPK12.50942422
12CDC72.50574826
13YES12.41785952
14CASK2.38843979
15MAPKAPK32.16900029
16CDK122.16772695
17SIK32.16648967
18PIK3CA2.12191954
19NEK12.06144223
20FRK2.05726141
21CDK82.04986779
22TTK1.98184642
23PLK31.95753695
24* MAP2K61.86008017
25EEF2K1.73080124
26RIPK41.69725428
27ATR1.61534326
28CDK71.61296234
29NEK21.59428803
30PLK11.59244566
31BRD41.53468157
32OXSR11.49736047
33PASK1.49610006
34TGFBR11.47936275
35ZAK1.45688297
36AKT31.43899369
37BCKDK1.38808111
38EPHB11.28980429
39DYRK31.25559318
40PAK41.23669645
41STK391.21187697
42VRK11.19999044
43STK101.19798846
44WNK41.14575591
45MELK1.14126420
46FGFR11.12113813
47PLK41.11403042
48AURKB1.10237159
49BRSK11.08958877
50ERBB31.06370954
51CHEK21.05762513
52SGK21.05299739
53DYRK1B1.00755485
54HIPK21.00750394
55EIF2AK10.99034269
56WNK30.98045020
57NTRK20.97710989
58DYRK20.96839622
59MAPKAPK50.95763233
60* TAOK20.94825593
61EIF2AK20.91965981
62EPHB20.91580154
63AKT20.91031739
64MAPK130.90574382
65LATS20.89411052
66MARK10.87943407
67NLK0.86772070
68STK38L0.83875126
69TAF10.83528598
70TRPM70.82487293
71MAP2K30.82277768
72KSR10.81210492
73MAP3K100.80641484
74CDK40.80300721
75PRPF4B0.80160338
76TNIK0.78681418
77FGFR20.78600607
78ATM0.78404672
79CHEK10.77442768
80PLK20.77298431
81MAPK70.75077218
82BRSK20.74216967
83CLK10.73484287
84CDK10.72927088
85AURKA0.71702337
86CDK20.70504964
87DAPK10.69562519
88STK160.67060376
89EPHA30.66836344
90GRK60.66183468
91CDC42BPA0.65802286
92TLK10.63991760
93DYRK1A0.62578441
94* MAP3K80.62421046
95RPS6KB20.60197469
96MST40.60056389
97CSF1R0.60033388
98LATS10.59410072
99OBSCN0.58768370
100TAOK30.58753745
101MAP3K120.58034486
102STK30.55666488
103MARK30.54449785
104CSNK2A10.54125229
105MATK0.51862843
106* MAP3K50.51415480
107NUAK10.50722407
108MAPK110.48663564
109CDK60.46963307
110BCR0.46419570
111RPS6KB10.46348829
112TIE10.46332993
113NME20.44712252
114SGK30.44623137
115PDK20.44520452
116CSNK1G30.43726788
117MINK10.43573639
118PHKG10.42604157
119PHKG20.42604157
120CDK190.41917592
121STK40.41870714
122VRK20.41492102
123IRAK40.41371299
124PDGFRA0.41351906
125EPHA40.40351185
126CSNK2A20.39991123
127PRKCG0.39056450
128CSNK1E0.38432079
129CSNK1G10.38289834
130TYRO30.38104744
131MAP3K70.37115365
132PRKDC0.36052648
133PRKCZ0.35789739
134STK110.35273807
135MAPK80.35246412
136EPHA20.34640858
137STK240.33838364
138PRKCQ0.33425111
139CSNK1A1L0.32885593
140MAPK140.32654117
141PRKAA20.32596069
142CSNK1G20.32308574
143MARK20.29891033
144RET0.26924177
145CSNK1A10.24535217
146INSRR0.23956737
147MAP3K40.21820386
148PRKAA10.18954140
149ADRBK20.16014767
150PRKACB0.15906563
151PDK10.15143795
152CAMK1D0.14362657
153PRKD10.13531292
154MAPK40.13408126
155PAK30.12198279
156CDK50.10836017
157PDPK10.10413364
158CAMK40.09325208
159PRKG10.07848000
160PRKACG0.07762704
161GSK3B0.06897209
162CSNK1D0.05465599
163GRK10.04743678
164TNK20.04632357
165ADRBK10.04451960
166PRKCA0.04361347

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46141951
2Mismatch repair_Homo sapiens_hsa034304.01331229
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.66185017
4Spliceosome_Homo sapiens_hsa030403.61458553
5Cocaine addiction_Homo sapiens_hsa050303.53521701
6Base excision repair_Homo sapiens_hsa034103.47520785
7RNA polymerase_Homo sapiens_hsa030203.27492503
8Cell cycle_Homo sapiens_hsa041103.01809354
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85106790
10RNA transport_Homo sapiens_hsa030132.82230175
11Nucleotide excision repair_Homo sapiens_hsa034202.55208984
12Phototransduction_Homo sapiens_hsa047442.54857029
13Pyrimidine metabolism_Homo sapiens_hsa002402.38590403
14One carbon pool by folate_Homo sapiens_hsa006702.38144861
15Dilated cardiomyopathy_Homo sapiens_hsa054142.37574490
16Fanconi anemia pathway_Homo sapiens_hsa034602.35584011
17Proteasome_Homo sapiens_hsa030502.26954390
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24318463
19mRNA surveillance pathway_Homo sapiens_hsa030152.17943941
20Butanoate metabolism_Homo sapiens_hsa006502.13510506
21Homologous recombination_Homo sapiens_hsa034402.11831846
22Basal cell carcinoma_Homo sapiens_hsa052172.09194543
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00100300
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93725872
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.85374408
26Parkinsons disease_Homo sapiens_hsa050121.66041896
27RNA degradation_Homo sapiens_hsa030181.64816636
28Dorso-ventral axis formation_Homo sapiens_hsa043201.64565870
29Asthma_Homo sapiens_hsa053101.60700829
30Oxidative phosphorylation_Homo sapiens_hsa001901.52940359
31Ribosome_Homo sapiens_hsa030101.52314122
32Regulation of autophagy_Homo sapiens_hsa041401.50713304
33Alzheimers disease_Homo sapiens_hsa050101.49045733
34Non-homologous end-joining_Homo sapiens_hsa034501.45231241
35Basal transcription factors_Homo sapiens_hsa030221.43141351
36Purine metabolism_Homo sapiens_hsa002301.42042258
37Histidine metabolism_Homo sapiens_hsa003401.38326995
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33533998
39Hematopoietic cell lineage_Homo sapiens_hsa046401.33437088
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.29541536
41Biosynthesis of amino acids_Homo sapiens_hsa012301.26803522
42Notch signaling pathway_Homo sapiens_hsa043301.18910509
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18048068
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.17496591
45Hedgehog signaling pathway_Homo sapiens_hsa043401.16187743
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15951391
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14242986
48Hippo signaling pathway_Homo sapiens_hsa043901.13326641
49Salivary secretion_Homo sapiens_hsa049701.13155409
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12247448
51* Toxoplasmosis_Homo sapiens_hsa051451.08697782
52Caffeine metabolism_Homo sapiens_hsa002321.08075276
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03596061
54p53 signaling pathway_Homo sapiens_hsa041151.03278263
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01321639
56Cardiac muscle contraction_Homo sapiens_hsa042601.00313310
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.98068168
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95988488
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95899863
60ECM-receptor interaction_Homo sapiens_hsa045120.94507428
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94362927
62Wnt signaling pathway_Homo sapiens_hsa043100.92601740
63Glucagon signaling pathway_Homo sapiens_hsa049220.89611046
64Retinol metabolism_Homo sapiens_hsa008300.89217100
65Autoimmune thyroid disease_Homo sapiens_hsa053200.89105907
66Olfactory transduction_Homo sapiens_hsa047400.83702483
67Allograft rejection_Homo sapiens_hsa053300.83665481
68Oocyte meiosis_Homo sapiens_hsa041140.82144550
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81107350
70Oxytocin signaling pathway_Homo sapiens_hsa049210.80810693
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80234610
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79897126
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79631538
74Carbon metabolism_Homo sapiens_hsa012000.78731693
75Lysine degradation_Homo sapiens_hsa003100.78191859
76Fatty acid elongation_Homo sapiens_hsa000620.77162663
77HTLV-I infection_Homo sapiens_hsa051660.76076489
78* Epstein-Barr virus infection_Homo sapiens_hsa051690.75729471
79MicroRNAs in cancer_Homo sapiens_hsa052060.75719366
80Adherens junction_Homo sapiens_hsa045200.73985308
81Acute myeloid leukemia_Homo sapiens_hsa052210.73595508
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73454951
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71445689
84Circadian rhythm_Homo sapiens_hsa047100.70134880
85Nicotine addiction_Homo sapiens_hsa050330.69744553
86HIF-1 signaling pathway_Homo sapiens_hsa040660.69729715
87Tryptophan metabolism_Homo sapiens_hsa003800.65690974
88Colorectal cancer_Homo sapiens_hsa052100.65584176
89Alcoholism_Homo sapiens_hsa050340.64359050
90ErbB signaling pathway_Homo sapiens_hsa040120.63169060
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62895283
92Huntingtons disease_Homo sapiens_hsa050160.62392827
93Circadian entrainment_Homo sapiens_hsa047130.61865670
94Glutathione metabolism_Homo sapiens_hsa004800.60853525
95Herpes simplex infection_Homo sapiens_hsa051680.60119105
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.58739461
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57780899
98Fructose and mannose metabolism_Homo sapiens_hsa000510.57655359
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.57248649
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55682696
101Viral myocarditis_Homo sapiens_hsa054160.54612283
102Arachidonic acid metabolism_Homo sapiens_hsa005900.52065155
103TGF-beta signaling pathway_Homo sapiens_hsa043500.51905658
104Endometrial cancer_Homo sapiens_hsa052130.51512472
105Systemic lupus erythematosus_Homo sapiens_hsa053220.51175144
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50685037
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49906732
108* GnRH signaling pathway_Homo sapiens_hsa049120.49695912
109Thyroid cancer_Homo sapiens_hsa052160.48667917
110Phenylalanine metabolism_Homo sapiens_hsa003600.48503823
111Axon guidance_Homo sapiens_hsa043600.48092104
112Viral carcinogenesis_Homo sapiens_hsa052030.47356349
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47003499
114Pathways in cancer_Homo sapiens_hsa052000.46997029
115Chemical carcinogenesis_Homo sapiens_hsa052040.46778208
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46286360
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45324787
118Galactose metabolism_Homo sapiens_hsa000520.43659733
119Arginine and proline metabolism_Homo sapiens_hsa003300.43630489
120Prostate cancer_Homo sapiens_hsa052150.43307518
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42617917
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42012653
123Calcium signaling pathway_Homo sapiens_hsa040200.41657322
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41581140
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.41070586
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40890305
127beta-Alanine metabolism_Homo sapiens_hsa004100.40828908
128Amphetamine addiction_Homo sapiens_hsa050310.39945044
129Selenocompound metabolism_Homo sapiens_hsa004500.38548466
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38005239
131Glycerolipid metabolism_Homo sapiens_hsa005610.37914094
132Folate biosynthesis_Homo sapiens_hsa007900.37630265
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35933038
134Propanoate metabolism_Homo sapiens_hsa006400.35732258
135Staphylococcus aureus infection_Homo sapiens_hsa051500.35591491
136Glioma_Homo sapiens_hsa052140.35049150
137Ether lipid metabolism_Homo sapiens_hsa005650.34391427
138FoxO signaling pathway_Homo sapiens_hsa040680.34350970
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34271107
140Renin-angiotensin system_Homo sapiens_hsa046140.33406862
141Pentose phosphate pathway_Homo sapiens_hsa000300.32902832
142Small cell lung cancer_Homo sapiens_hsa052220.32553841
143* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32325242
144Peroxisome_Homo sapiens_hsa041460.31946551
145N-Glycan biosynthesis_Homo sapiens_hsa005100.31460812
146* Influenza A_Homo sapiens_hsa051640.31276481
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29481273
148Metabolic pathways_Homo sapiens_hsa011000.27652232
149Arginine biosynthesis_Homo sapiens_hsa002200.27595153
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25376810
151Cyanoamino acid metabolism_Homo sapiens_hsa004600.24077651
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24013404
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21893997
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21557431
155Shigellosis_Homo sapiens_hsa051310.21379915
156Tyrosine metabolism_Homo sapiens_hsa003500.21293879
157Primary immunodeficiency_Homo sapiens_hsa053400.21208963
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20173046

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