MAP2K7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.42557641
2positive regulation of histone deacetylation (GO:0031065)4.29152159
3modulation by virus of host process (GO:0019054)4.22556289
4negative regulation of cell size (GO:0045792)4.11727699
5mannose metabolic process (GO:0006013)4.08916005
6sodium ion export (GO:0071436)3.98007194
7thymic T cell selection (GO:0045061)3.96367518
83-UTR-mediated mRNA stabilization (GO:0070935)3.90369757
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85953403
10positive thymic T cell selection (GO:0045059)3.84331980
11positive regulation of gamma-delta T cell activation (GO:0046645)3.83286506
12modulation by symbiont of host cellular process (GO:0044068)3.76290039
13negative regulation of potassium ion transmembrane transport (GO:1901380)3.73403563
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70089511
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69118446
16negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.69039989
17negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.66878207
18plasma membrane repair (GO:0001778)3.60711826
19regulation of NFAT protein import into nucleus (GO:0051532)3.58383505
20positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.58185491
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.53312310
22modulation by symbiont of host defense response (GO:0052031)3.48935648
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48935648
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48935648
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.48935648
26modulation by symbiont of host immune response (GO:0052553)3.48935648
27positive regulation by symbiont of host defense response (GO:0052509)3.48935648
28antigen processing and presentation of endogenous antigen (GO:0019883)3.45524736
29response to muramyl dipeptide (GO:0032495)3.45323282
30peptidyl-lysine dimethylation (GO:0018027)3.43907470
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.41188367
32synaptic vesicle maturation (GO:0016188)3.35361968
33cell communication by electrical coupling (GO:0010644)3.35292538
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31579684
35T cell selection (GO:0045058)3.27891750
36pre-miRNA processing (GO:0031054)3.27723099
37apoptotic process involved in morphogenesis (GO:0060561)3.25578150
38regulation of gamma-delta T cell activation (GO:0046643)3.20132694
39cytoskeletal anchoring at plasma membrane (GO:0007016)3.17982099
40regulation of B cell receptor signaling pathway (GO:0050855)3.16773774
41macrophage activation involved in immune response (GO:0002281)3.16154479
42regulation of chromatin binding (GO:0035561)3.15873207
43germinal center formation (GO:0002467)3.15190504
44regulation of cholesterol homeostasis (GO:2000188)3.15159458
45negative thymic T cell selection (GO:0045060)3.05831618
46locomotory exploration behavior (GO:0035641)3.04633787
47NIK/NF-kappaB signaling (GO:0038061)3.03501848
48carnitine shuttle (GO:0006853)3.02170035
49activation of protein kinase A activity (GO:0034199)3.00944734
50tolerance induction (GO:0002507)3.00525897
51regulation of ARF protein signal transduction (GO:0032012)3.00520593
52negative regulation of viral release from host cell (GO:1902187)3.00234822
53signal complex assembly (GO:0007172)2.99961469
54regulation of fatty acid beta-oxidation (GO:0031998)2.98958089
55detection of bacterium (GO:0016045)2.97290860
56cellular response to virus (GO:0098586)2.97148128
57positive T cell selection (GO:0043368)2.97000706
58leukocyte aggregation (GO:0070486)2.95350762
59cardiac myofibril assembly (GO:0055003)2.94418884
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91505744
61negative regulation of toll-like receptor signaling pathway (GO:0034122)2.90232888
62dicarboxylic acid biosynthetic process (GO:0043650)2.89836140
63response to peptidoglycan (GO:0032494)2.88918558
64regulation of ARF GTPase activity (GO:0032312)2.88512327
65B cell receptor signaling pathway (GO:0050853)2.87971901
66detection of other organism (GO:0098543)2.86266314
67cardiac muscle contraction (GO:0060048)2.85287083
68regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.85197209
69negative T cell selection (GO:0043383)2.84560814
70cytoplasmic mRNA processing body assembly (GO:0033962)2.83059009
71adherens junction assembly (GO:0034333)2.82757798
72histone H3-K36 demethylation (GO:0070544)2.82491004
73focal adhesion assembly (GO:0048041)2.82054853
74cell-substrate adherens junction assembly (GO:0007045)2.82054853
75cellular potassium ion homeostasis (GO:0030007)2.81627438
76potassium ion import (GO:0010107)2.81349118
77positive regulation of protein deacetylation (GO:0090312)2.80724457
78activation of Rac GTPase activity (GO:0032863)2.76357490
79neutrophil activation involved in immune response (GO:0002283)2.76180813
80response to laminar fluid shear stress (GO:0034616)2.76030863
81NLS-bearing protein import into nucleus (GO:0006607)2.75224367
82regulation of histone H3-K27 methylation (GO:0061085)2.73391308
83regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71210599
84negative regulation of nucleotide catabolic process (GO:0030812)2.70904817
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69888854
86embryonic process involved in female pregnancy (GO:0060136)2.69598294
87sarcomere organization (GO:0045214)2.69287171
88regulation of interferon-beta biosynthetic process (GO:0045357)2.68811497
89fatty acid transmembrane transport (GO:1902001)2.68600593
90regulation of necroptotic process (GO:0060544)2.68367013
91regulation of leukocyte degranulation (GO:0043300)2.68259909
92modulation by virus of host morphology or physiology (GO:0019048)2.67208824
93regulation of short-term neuronal synaptic plasticity (GO:0048172)2.65133929
94activation of MAPKKK activity (GO:0000185)2.63459304
95positive regulation of Rap GTPase activity (GO:0032854)2.63100779
96cell communication involved in cardiac conduction (GO:0086065)2.62826038
97intracellular estrogen receptor signaling pathway (GO:0030520)2.62120067
98response to interleukin-15 (GO:0070672)2.61750886
99negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61377906
100negative regulation of cell killing (GO:0031342)2.61377906
101positive regulation of glycogen biosynthetic process (GO:0045725)2.60965151
102negative regulation of cAMP-mediated signaling (GO:0043951)2.59775598
103insulin-like growth factor receptor signaling pathway (GO:0048009)2.58852577
104positive regulation of CREB transcription factor activity (GO:0032793)2.58248742
105regulation of fatty acid oxidation (GO:0046320)2.56700166
106positive regulation of protein dephosphorylation (GO:0035307)2.56489201
107antigen processing and presentation via MHC class Ib (GO:0002475)2.56460110
108histone H4 deacetylation (GO:0070933)2.55962074
109positive regulation of glycogen metabolic process (GO:0070875)2.55524064
110regulation of gamma-delta T cell differentiation (GO:0045586)2.55324828
111regulation of clathrin-mediated endocytosis (GO:2000369)2.53280075
112stress fiber assembly (GO:0043149)2.52961747
113negative regulation of necroptotic process (GO:0060546)2.52752187
114negative regulation of myotube differentiation (GO:0010832)2.52712971
115negative regulation of cardiac muscle tissue growth (GO:0055022)2.51186133
116negative regulation of heart growth (GO:0061117)2.51186133
1172-oxoglutarate metabolic process (GO:0006103)2.50839431
118regulation of p38MAPK cascade (GO:1900744)2.50797062
119regulation of defense response to virus by virus (GO:0050690)2.49433158
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.48574578
121megakaryocyte development (GO:0035855)2.48107436
122protein localization to endosome (GO:0036010)2.47851038
123negative regulation of leukocyte mediated immunity (GO:0002704)2.45812640
124positive regulation of myotube differentiation (GO:0010831)2.45744543
125positive regulation of fatty acid beta-oxidation (GO:0032000)2.45484301
126positive regulation of Cdc42 GTPase activity (GO:0043089)2.43461843
127B cell homeostasis (GO:0001782)2.43414070
128layer formation in cerebral cortex (GO:0021819)2.43055276
129establishment of nucleus localization (GO:0040023)2.42826330
130cell-substrate junction assembly (GO:0007044)2.42015828
131stress granule assembly (GO:0034063)2.41880220
132negative regulation of potassium ion transport (GO:0043267)2.41325187
133regulation of translational termination (GO:0006449)2.41144549
134negative regulation of innate immune response (GO:0045824)2.40252931
135macroautophagy (GO:0016236)2.39717772
136positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39598436
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38339235
138positive regulation of triglyceride biosynthetic process (GO:0010867)2.37308019
139regulation of mast cell degranulation (GO:0043304)2.37021321
140negative regulation of lymphocyte mediated immunity (GO:0002707)2.36442026
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36316793
142cellular sodium ion homeostasis (GO:0006883)2.35858796
143detection of external biotic stimulus (GO:0098581)2.35268232
144mucosal-associated lymphoid tissue development (GO:0048537)2.35198633
145Peyers patch development (GO:0048541)2.35198633
146cerebellar Purkinje cell differentiation (GO:0021702)2.34856507
147negative regulation of granulocyte differentiation (GO:0030853)2.34360031
148regulation of T cell tolerance induction (GO:0002664)2.33923277
149maternal placenta development (GO:0001893)2.33576787
150myofibril assembly (GO:0030239)2.33147737
151synaptic vesicle docking involved in exocytosis (GO:0016081)2.32916518
152regulation of translational fidelity (GO:0006450)2.32862571
153response to type I interferon (GO:0034340)2.32604542
154lysine catabolic process (GO:0006554)2.32381227
155lysine metabolic process (GO:0006553)2.32381227
156regulation of B cell differentiation (GO:0045577)2.32260688
157negative regulation of purine nucleotide catabolic process (GO:0033122)2.29894494
158alanine transport (GO:0032328)2.29125949
159regulation of tight junction assembly (GO:2000810)2.28186983
160carnitine transmembrane transport (GO:1902603)2.27493943
161activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.26892796
162regulation of histone deacetylation (GO:0031063)2.25479711
163peptidyl-threonine phosphorylation (GO:0018107)2.24998543
164regulation of hippo signaling (GO:0035330)2.24420134
165histone H3-K9 demethylation (GO:0033169)2.22125435
166membrane repolarization (GO:0086009)2.19499039
167regulation of the force of heart contraction (GO:0002026)2.18998769
168peptidyl-threonine modification (GO:0018210)2.17005844
169proline transport (GO:0015824)2.16566099
170tricarboxylic acid metabolic process (GO:0072350)2.16450636
171G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.16243670
172regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.16121901
173regulation of synapse structural plasticity (GO:0051823)2.15259562
174positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.15258529
175potassium ion homeostasis (GO:0055075)2.14780517
176heterochromatin organization (GO:0070828)2.14429755
177growth hormone secretion (GO:0030252)2.14079080
178regulation of early endosome to late endosome transport (GO:2000641)2.13322271
179positive regulation of nuclease activity (GO:0032075)2.12032090
180striated muscle contraction (GO:0006941)2.11699513
181regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.11536074
182glucocorticoid receptor signaling pathway (GO:0042921)2.11535396
183amino-acid betaine transport (GO:0015838)2.10902227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06905715
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.98469140
3MYC_22102868_ChIP-Seq_BL_Human2.94238881
4* KDM2B_26808549_Chip-Seq_DND41_Human2.76221286
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.75629183
6TCF7_22412390_ChIP-Seq_EML_Mouse2.44654388
7* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.38166886
8* LXR_22292898_ChIP-Seq_THP-1_Human2.36799290
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.34977801
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.29263994
11KDM2B_26808549_Chip-Seq_K562_Human2.18113096
12VDR_24763502_ChIP-Seq_THP-1_Human2.07976619
13ZFP281_27345836_Chip-Seq_ESCs_Mouse2.04257645
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04018472
15KDM2B_26808549_Chip-Seq_JURKAT_Human2.02912083
16RARB_27405468_Chip-Seq_BRAIN_Mouse1.96643041
17* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.94496385
18ZNF263_19887448_ChIP-Seq_K562_Human1.94147986
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93595439
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91801488
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90041690
22MAF_26560356_Chip-Seq_TH2_Human1.89996449
23VDR_21846776_ChIP-Seq_THP-1_Human1.89852410
24* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88579934
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88033397
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.87827501
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86225081
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.80657763
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.79861886
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71677593
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.69442974
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66676749
33DROSHA_22980978_ChIP-Seq_HELA_Human1.66352927
34RACK7_27058665_Chip-Seq_MCF-7_Human1.65620201
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64899605
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64230037
37CREB1_26743006_Chip-Seq_LNCaP_Human1.63816147
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63360687
39EZH2_22144423_ChIP-Seq_EOC_Human1.61972374
40* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61859485
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61709371
42CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56943630
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56367900
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55431609
45* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54581330
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53162289
47* P68_20966046_ChIP-Seq_HELA_Human1.52058665
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.51274906
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50568892
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.47869376
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47479964
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47033441
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.45892647
54TBX20_22080862_ChIP-Seq_HEART_Mouse1.45892647
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.45689675
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.45131480
57TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.42956020
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42877786
59SMC4_20622854_ChIP-Seq_HELA_Human1.42510567
60SCL_19346495_ChIP-Seq_HPC-7_Human1.36526755
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.34755112
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34429221
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32494099
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32449712
65UTX_26944678_Chip-Seq_JUKART_Human1.31299188
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30740856
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.30153742
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.29460117
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.27961586
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.27646190
71MAF_26560356_Chip-Seq_TH1_Human1.27264514
72NCOR1_26117541_ChIP-Seq_K562_Human1.26916602
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26552581
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26341918
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24970048
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24267847
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23437739
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21400481
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.20669293
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20652592
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19670011
82* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19470413
83* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19402015
84GATA1_19941826_ChIP-Seq_K562_Human1.19064969
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18868158
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18046519
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17628899
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17580903
89SPI1_23127762_ChIP-Seq_K562_Human1.17440799
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16995270
91CLOCK_20551151_ChIP-Seq_293T_Human1.16904413
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16840895
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13855346
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13804711
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.13363079
96* TP63_22573176_ChIP-Seq_HFKS_Human1.12805762
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12771712
98MYB_26560356_Chip-Seq_TH1_Human1.12669477
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.12568570
100* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11417493
101* ATF3_27146783_Chip-Seq_COLON_Human1.11194567
102* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11192903
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10119115
104CTCF_27219007_Chip-Seq_Bcells_Human1.09976210
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09408360
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08879828
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08575947
108* PHF8_20622854_ChIP-Seq_HELA_Human1.08469107
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08402762
110IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08099206
111CIITA_25753668_ChIP-Seq_RAJI_Human1.07232510
112SA1_27219007_Chip-Seq_Bcells_Human1.06020007
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05960285
114CTCF_26484167_Chip-Seq_Bcells_Mouse1.05774386
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05001811
116SA1_27219007_Chip-Seq_ERYTHROID_Human1.04721494
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03646065
118* E2F1_20622854_ChIP-Seq_HELA_Human1.03442449
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02567843
120BCOR_27268052_Chip-Seq_Bcells_Human1.02116762
121OCT4_19829295_ChIP-Seq_ESCs_Human1.02070346
122* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02036175
123CTCF_21964334_Chip-Seq_Bcells_Human1.01813750
124MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01679126
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01258107
126* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01149603
127STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00294225
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98581624
129* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98268558
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96691727
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96059896
132BCL6_27268052_Chip-Seq_Bcells_Human0.95694608
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94465624
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94271242
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94007510
136TP53_22127205_ChIP-Seq_IMR90_Human0.93882277
137TP53_23651856_ChIP-Seq_MEFs_Mouse0.92928443
138* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92380850
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.92011154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.82344129
2MP0003705_abnormal_hypodermis_morpholog3.51838130
3MP0003436_decreased_susceptibility_to3.42629512
4MP0008961_abnormal_basal_metabolism3.41636208
5MP0000751_myopathy2.99163693
6MP0004859_abnormal_synaptic_plasticity2.96843393
7MP0002837_dystrophic_cardiac_calcinosis2.94988019
8MP0002909_abnormal_adrenal_gland2.65486268
9MP0004084_abnormal_cardiac_muscle2.58319195
10MP0004130_abnormal_muscle_cell2.54681293
11MP0003763_abnormal_thymus_physiology2.52618653
12MP0003646_muscle_fatigue2.50472124
13MP0004233_abnormal_muscle_weight2.42932628
14MP0000685_abnormal_immune_system2.32828424
15MP0005670_abnormal_white_adipose2.28036687
16MP0009333_abnormal_splenocyte_physiolog2.27516305
17MP0004087_abnormal_muscle_fiber2.23499738
18MP0004036_abnormal_muscle_relaxation2.18055901
19MP0002269_muscular_atrophy2.13247481
20MP0008260_abnormal_autophagy2.11397522
21MP0004947_skin_inflammation2.07375477
22MP0001873_stomach_inflammation2.07341242
23MP0005076_abnormal_cell_differentiation2.03295862
24MP0010352_gastrointestinal_tract_polyps2.00231784
25MP0001348_abnormal_lacrimal_gland1.99965392
26MP0003300_gastrointestinal_ulcer1.96300186
27MP0002822_catalepsy1.94810307
28MP0001800_abnormal_humoral_immune1.93288353
29MP0005058_abnormal_lysosome_morphology1.91662015
30MP0000747_muscle_weakness1.89919034
31MP0004381_abnormal_hair_follicle1.86598499
32MP0005000_abnormal_immune_tolerance1.85935586
33MP0002653_abnormal_ependyma_morphology1.85732542
34MP0010630_abnormal_cardiac_muscle1.83814903
35MP0000678_abnormal_parathyroid_gland1.80651099
36MP0005330_cardiomyopathy1.79861785
37MP0005025_abnormal_response_to1.79587149
38MP0004858_abnormal_nervous_system1.79585108
39MP0001835_abnormal_antigen_presentation1.79156290
40MP0003283_abnormal_digestive_organ1.76545424
41MP0005666_abnormal_adipose_tissue1.74301645
42MP0000749_muscle_degeneration1.73128488
43MP0002419_abnormal_innate_immunity1.72819260
44MP0002420_abnormal_adaptive_immunity1.71938277
45MP0001790_abnormal_immune_system1.71772003
46MP0005387_immune_system_phenotype1.71772003
47MP0002723_abnormal_immune_serum1.70800047
48MP0002398_abnormal_bone_marrow1.70362841
49MP0001819_abnormal_immune_cell1.69599195
50MP0000703_abnormal_thymus_morphology1.68143739
51MP0004145_abnormal_muscle_electrophysio1.67232695
52MP0005375_adipose_tissue_phenotype1.66788440
53MP0000003_abnormal_adipose_tissue1.66581606
54MP0003191_abnormal_cellular_cholesterol1.64924001
55MP0002396_abnormal_hematopoietic_system1.64596159
56MP0003303_peritoneal_inflammation1.63598443
57MP0005671_abnormal_response_to1.62293970
58MP0000759_abnormal_skeletal_muscle1.62174904
59MP0004185_abnormal_adipocyte_glucose1.55973301
60MP0002452_abnormal_antigen_presenting1.55854126
61MP0003045_fibrosis1.53581172
62MP0000013_abnormal_adipose_tissue1.48492018
63MP0003453_abnormal_keratinocyte_physiol1.46883835
64MP0000716_abnormal_immune_system1.44591977
65MP0002106_abnormal_muscle_physiology1.44529520
66MP0000858_altered_metastatic_potential1.44491843
67MP0004215_abnormal_myocardial_fiber1.43772478
68MP0002249_abnormal_larynx_morphology1.43546438
69MP0009278_abnormal_bone_marrow1.39936009
70MP0002722_abnormal_immune_system1.34681679
71MP0000750_abnormal_muscle_regeneration1.31139020
72MP0002405_respiratory_system_inflammati1.31064014
73MP0003635_abnormal_synaptic_transmissio1.28900527
74MP0008775_abnormal_heart_ventricle1.28634206
75MP0009780_abnormal_chondrocyte_physiolo1.27910603
76MP0001849_ear_inflammation1.27773281
77MP0001533_abnormal_skeleton_physiology1.27582015
78MP0005409_darkened_coat_color1.26430563
79MP0002429_abnormal_blood_cell1.26100675
80MP0005620_abnormal_muscle_contractility1.24468672
81MP0000733_abnormal_muscle_development1.24308239
82MP0004808_abnormal_hematopoietic_stem1.21928568
83MP0010155_abnormal_intestine_physiology1.19955185
84MP0003724_increased_susceptibility_to1.18865864
85MP0002933_joint_inflammation1.18814458
86MP0008569_lethality_at_weaning1.18566588
87MP0005623_abnormal_meninges_morphology1.18439312
88MP0000689_abnormal_spleen_morphology1.17386704
89MP0005369_muscle_phenotype1.14627345
90MP0002148_abnormal_hypersensitivity_rea1.14197082
91MP0001545_abnormal_hematopoietic_system1.13323110
92MP0005397_hematopoietic_system_phenotyp1.13323110
93MP0005310_abnormal_salivary_gland1.12522234
94MP0003137_abnormal_impulse_conducting1.11499185
95MP0005464_abnormal_platelet_physiology1.10314592
96MP0002998_abnormal_bone_remodeling1.09947001
97MP0003329_amyloid_beta_deposits1.09602927
98MP0002254_reproductive_system_inflammat1.09180610
99MP0002796_impaired_skin_barrier1.08506160
100MP0002234_abnormal_pharynx_morphology1.07716119
101MP0004085_abnormal_heartbeat1.05670202
102MP0000266_abnormal_heart_morphology1.04908746
103MP0002972_abnormal_cardiac_muscle1.04743356
104MP0005365_abnormal_bile_salt1.04689246
105MP0000569_abnormal_digit_pigmentation1.03784930
106MP0005385_cardiovascular_system_phenoty1.03156090
107MP0001544_abnormal_cardiovascular_syste1.03156090
108MP0010329_abnormal_lipoprotein_level1.02280162
109MP0009672_abnormal_birth_weight1.02164436
110MP0003566_abnormal_cell_adhesion1.01970654
111MP0003866_abnormal_defecation1.01815373
112MP0009785_altered_susceptibility_to1.01759778
113MP0008770_decreased_survivor_rate0.99451657
114MP0003172_abnormal_lysosome_physiology0.99411055
115MP0003252_abnormal_bile_duct0.99254697
116MP0002138_abnormal_hepatobiliary_system0.98358163
117MP0003828_pulmonary_edema0.96911510
118MP0003656_abnormal_erythrocyte_physiolo0.96662950
119MP0009931_abnormal_skin_appearance0.95943493
120MP0004510_myositis0.95711662
121MP0001851_eye_inflammation0.94708341
122MP0010234_abnormal_vibrissa_follicle0.92671967
123MP0005187_abnormal_penis_morphology0.92271429
124MP0002877_abnormal_melanocyte_morpholog0.91955035
125MP0005083_abnormal_biliary_tract0.91808073
126MP0001845_abnormal_inflammatory_respons0.91315518
127MP0003091_abnormal_cell_migration0.91018338
128MP0004811_abnormal_neuron_physiology0.90714074
129MP0004197_abnormal_fetal_growth/weight/0.88833139
130MP0002971_abnormal_brown_adipose0.87423374
131MP0005501_abnormal_skin_physiology0.87329750
132MP0003787_abnormal_imprinting0.87117545
133MP0002078_abnormal_glucose_homeostasis0.87088510
134MP0005167_abnormal_blood-brain_barrier0.87042890
135MP0002970_abnormal_white_adipose0.84668617
136MP0004264_abnormal_extraembryonic_tissu0.82942864
137MP0009840_abnormal_foam_cell0.82824736
138MP0002925_abnormal_cardiovascular_devel0.82279323
139MP0002127_abnormal_cardiovascular_syste0.82069789
140MP0008874_decreased_physiological_sensi0.81718830
141MP0002089_abnormal_postnatal_growth/wei0.81207365
142MP0002063_abnormal_learning/memory/cond0.80345691
143MP0003183_abnormal_peptide_metabolism0.79443689
144MP0003115_abnormal_respiratory_system0.77872280
145MP0003122_maternal_imprinting0.76885443
146MP0003075_altered_response_to0.76205027
147MP0000609_abnormal_liver_physiology0.76203557
148MP0009703_decreased_birth_body0.75488209
149MP0002088_abnormal_embryonic_growth/wei0.74540901
150MP0005390_skeleton_phenotype0.74326648
151MP0003633_abnormal_nervous_system0.74247438
152MP0003279_aneurysm0.73149284
153MP0003984_embryonic_growth_retardation0.72579160
154MP0000490_abnormal_crypts_of0.71645427
155MP0002108_abnormal_muscle_morphology0.71557753
156MP0002086_abnormal_extraembryonic_tissu0.71380016
157MP0006138_congestive_heart_failure0.71343038
158MP0009115_abnormal_fat_cell0.70735760
159MP0002084_abnormal_developmental_patter0.70477953
160MP0002064_seizures0.69088470
161MP0005334_abnormal_fat_pad0.69062379
162MP0003221_abnormal_cardiomyocyte_apopto0.68648545
163MP0008469_abnormal_protein_level0.68602858
164MP0002118_abnormal_lipid_homeostasis0.66954318
165MP0009046_muscle_twitch0.64531258

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.22333143
2Eczematoid dermatitis (HP:0000976)3.75387038
3Exercise-induced myalgia (HP:0003738)3.58830987
4Abnormality of the lower motor neuron (HP:0002366)3.49987974
5Cerebral aneurysm (HP:0004944)3.35686072
6Difficulty running (HP:0009046)3.28671801
7Exercise-induced muscle cramps (HP:0003710)3.26831224
8Hyporeflexia of lower limbs (HP:0002600)3.25863251
9Hyperacusis (HP:0010780)3.22134482
10Dysmetric saccades (HP:0000641)3.19645327
11Increased IgE level (HP:0003212)3.18103430
12Macroorchidism (HP:0000053)3.04021927
13Sudden death (HP:0001699)2.99640854
14Bundle branch block (HP:0011710)2.98235271
15Myopathic facies (HP:0002058)2.92567344
16Neoplasm of the heart (HP:0100544)2.92403131
17Centrally nucleated skeletal muscle fibers (HP:0003687)2.91835116
18Increased connective tissue (HP:0009025)2.83505649
19Asymmetric septal hypertrophy (HP:0001670)2.81182523
20Myoglobinuria (HP:0002913)2.80752417
21Upper limb amyotrophy (HP:0009129)2.77058680
22Distal upper limb amyotrophy (HP:0007149)2.77058680
23Distal lower limb amyotrophy (HP:0008944)2.76677489
24Broad face (HP:0000283)2.73466558
25Gastrointestinal infarctions (HP:0005244)2.72401326
26Recurrent bacterial skin infections (HP:0005406)2.70602416
27Pustule (HP:0200039)2.69400256
28Recurrent abscess formation (HP:0002722)2.57394876
29Cellulitis (HP:0100658)2.57252677
30Myositis (HP:0100614)2.55115194
31Segmental peripheral demyelination/remyelination (HP:0003481)2.52755150
32Distal lower limb muscle weakness (HP:0009053)2.50459869
33Hand muscle atrophy (HP:0009130)2.48400552
34Chronic obstructive pulmonary disease (HP:0006510)2.47788008
35Obstructive lung disease (HP:0006536)2.47788008
36EMG: neuropathic changes (HP:0003445)2.46137254
37Difficulty climbing stairs (HP:0003551)2.45290928
38Ventricular fibrillation (HP:0001663)2.43111117
39Astrocytoma (HP:0009592)2.43044988
40Abnormality of the astrocytes (HP:0100707)2.43044988
41Hypochromic anemia (HP:0001931)2.43003488
42Insomnia (HP:0100785)2.41242797
43Aneurysm (HP:0002617)2.39494377
44Abnormality of macrophages (HP:0004311)2.36448653
45Gastrointestinal inflammation (HP:0004386)2.35109871
46Disproportionate tall stature (HP:0001519)2.33752534
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33167076
48Ventricular tachycardia (HP:0004756)2.32537863
49Meningitis (HP:0001287)2.31780329
50Achilles tendon contracture (HP:0001771)2.31706101
51Colitis (HP:0002583)2.29646024
52Subaortic stenosis (HP:0001682)2.29362316
53Abnormality of the left ventricular outflow tract (HP:0011103)2.29362316
54Enlarged penis (HP:0000040)2.28996455
55Recurrent fungal infections (HP:0002841)2.28298290
56Easy fatigability (HP:0003388)2.27136045
57Abnormality of the Achilles tendon (HP:0005109)2.26721424
58Stridor (HP:0010307)2.25656733
59Elfin facies (HP:0004428)2.24147877
60Lymphangioma (HP:0100764)2.22887044
61Elevated erythrocyte sedimentation rate (HP:0003565)2.21596992
62Mediastinal lymphadenopathy (HP:0100721)2.21462146
63Increased variability in muscle fiber diameter (HP:0003557)2.21203324
64Broad metatarsal (HP:0001783)2.20511222
65Gastrointestinal stroma tumor (HP:0100723)2.19515028
66Rectal prolapse (HP:0002035)2.17907139
67Hypertensive crisis (HP:0100735)2.17254190
68Hemorrhage of the eye (HP:0011885)2.16957402
69Resting tremor (HP:0002322)2.16119096
70Fibroma (HP:0010614)2.15452966
71Orchitis (HP:0100796)2.14725158
72Emphysema (HP:0002097)2.13687177
73Renovascular hypertension (HP:0100817)2.13302002
74Calf muscle hypertrophy (HP:0008981)2.12648800
75Long palpebral fissure (HP:0000637)2.11307175
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11290174
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.10214833
78Ulnar deviation of the wrist (HP:0003049)2.10111939
79Type 1 muscle fiber predominance (HP:0003803)2.08128817
80Abnormality of the thoracic spine (HP:0100711)2.07544511
81Muscle fiber splitting (HP:0003555)2.07334915
82Turricephaly (HP:0000262)2.07212124
83Atrioventricular block (HP:0001678)2.07032023
84Hypercortisolism (HP:0001578)2.06588169
85Hemiplegia (HP:0002301)2.06235921
86Hamartoma of the eye (HP:0010568)2.06112008
87Inflammation of the large intestine (HP:0002037)2.05651509
88Heart block (HP:0012722)2.04306165
89Frequent falls (HP:0002359)2.04093557
90Annular pancreas (HP:0001734)2.03549856
91Ependymoma (HP:0002888)2.03514167
92Fibrous tissue neoplasm (HP:0012316)2.02937006
93Abnormality of the columella (HP:0009929)2.00198323
94Visual hallucinations (HP:0002367)2.00009109
95Pointed chin (HP:0000307)1.99378848
96Chest pain (HP:0100749)1.97116883
97Ventricular arrhythmia (HP:0004308)1.96163006
98Gingivitis (HP:0000230)1.95953885
99Spontaneous hematomas (HP:0007420)1.95868234
100Shallow orbits (HP:0000586)1.95713356
101Mildly elevated creatine phosphokinase (HP:0008180)1.95249931
102Impaired social interactions (HP:0000735)1.95130707
103Abnormal social behavior (HP:0012433)1.95130707
104Chronic mucocutaneous candidiasis (HP:0002728)1.95122342
105Recurrent cutaneous fungal infections (HP:0011370)1.95122342
106Round ear (HP:0100830)1.95026113
107Metaphyseal cupping (HP:0003021)1.94223943
108Long toe (HP:0010511)1.93632262
109Recurrent skin infections (HP:0001581)1.93271796
110Heterotopia (HP:0002282)1.93193573
111Polygenic inheritance (HP:0010982)1.92880084
112Abnormal atrioventricular conduction (HP:0005150)1.92027843
113Back pain (HP:0003418)1.91050887
114Abnormality of skeletal muscle fiber size (HP:0012084)1.90832279
115Myotonia (HP:0002486)1.90369407
116Recurrent viral infections (HP:0004429)1.90203119
117Thoracic kyphosis (HP:0002942)1.89358416
118Increased cerebral lipofuscin (HP:0011813)1.89050473
119Muscle hypertrophy of the lower extremities (HP:0008968)1.88466714
120Atrial fibrillation (HP:0005110)1.88037983
121Rapidly progressive (HP:0003678)1.88007471
122Postural instability (HP:0002172)1.87473854
123Slow saccadic eye movements (HP:0000514)1.86788427
124Thin bony cortex (HP:0002753)1.85851992
125Deep palmar crease (HP:0006191)1.85546847
126Striae distensae (HP:0001065)1.84648047
127Renal duplication (HP:0000075)1.83900310
128Abnormality of the calf musculature (HP:0001430)1.83814441
129Increased neuronal autofluorescent lipopigment (HP:0002074)1.82843432
130Primary atrial arrhythmia (HP:0001692)1.81979794
131EMG: myopathic abnormalities (HP:0003458)1.81775799
132Bowel incontinence (HP:0002607)1.81735875
133Vasculitis (HP:0002633)1.81330871
134Right ventricular cardiomyopathy (HP:0011663)1.81107282
135Bulbar palsy (HP:0001283)1.80781019
136Germ cell neoplasia (HP:0100728)1.80767556
137Onion bulb formation (HP:0003383)1.80613899
138Increased serum ferritin (HP:0003281)1.80558195
139Muscle fiber inclusion bodies (HP:0100299)1.77430150
140Central scotoma (HP:0000603)1.76270069
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76072298
142Deep venous thrombosis (HP:0002625)1.76009278
143Mitral valve prolapse (HP:0001634)1.75435589
144Pseudobulbar signs (HP:0002200)1.74466294
145Dysostosis multiplex (HP:0000943)1.74067506
146Polycythemia (HP:0001901)1.73871500
147Dislocated radial head (HP:0003083)1.72151529
148Depression (HP:0000716)1.71935376
149Global brain atrophy (HP:0002283)1.71895873
150Urticaria (HP:0001025)1.71388200
151Seborrheic dermatitis (HP:0001051)1.71369820
152Axonal loss (HP:0003447)1.70904852
153Supranuclear gaze palsy (HP:0000605)1.70683140
154Overriding aorta (HP:0002623)1.70587210
155Abnormality of the aortic arch (HP:0012303)1.70326446
156Agammaglobulinemia (HP:0004432)1.70018125
157Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.70006240
158Hypertriglyceridemia (HP:0002155)1.69074590
159Supraventricular arrhythmia (HP:0005115)1.68864135
160Encephalitis (HP:0002383)1.68572087
161Ulnar bowing (HP:0003031)1.68531100
162Supraventricular tachycardia (HP:0004755)1.68506702
163Prolonged QT interval (HP:0001657)1.68424520
164Focal seizures (HP:0007359)1.68067430
165Bowel diverticulosis (HP:0005222)1.66488951
166Stomatitis (HP:0010280)1.66193091
167Prolonged bleeding time (HP:0003010)1.65898754
168J-shaped sella turcica (HP:0002680)1.65799849
169Lower limb amyotrophy (HP:0007210)1.64855838
170Obsessive-compulsive behavior (HP:0000722)1.64694239
171Ketoacidosis (HP:0001993)1.64194265
172Reticulocytosis (HP:0001923)1.63973614
173Aortic aneurysm (HP:0004942)1.63861179
174Abnormality of the fingertips (HP:0001211)1.63548314
175Urethral obstruction (HP:0000796)1.61338998
176Genetic anticipation (HP:0003743)1.61235650
177Protrusio acetabuli (HP:0003179)1.60686282
178Status epilepticus (HP:0002133)1.60087747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.22100541
2PRPF4B3.70523167
3ICK3.39127966
4SMG13.26610199
5PKN23.04386289
6PRKD32.74048099
7MAP3K102.60060503
8EEF2K2.58036487
9TTN2.55419485
10CDK122.54794755
11RIPK42.36603161
12ERN12.29939817
13RIPK12.27452706
14PDGFRA1.81376837
15SIK11.81128749
16IRAK31.76949502
17CAMK1G1.74877036
18TYRO31.71466913
19MAP3K91.65702344
20SIK21.64071155
21TAOK11.61158008
22MAP3K71.60841000
23KSR21.52115353
24IRAK41.51933185
25STK381.48651037
26SIK31.46422371
27DMPK1.42773410
28ALK1.39102317
29PHKG11.38689679
30PHKG21.38689679
31PTK61.33656226
32MAP3K31.27807001
33CAMK1D1.27475473
34MTOR1.26573248
35PAK61.26486791
36TAOK21.20926599
37LMTK21.18991395
38PRKCH1.18877778
39FGFR41.13283261
40TBK11.11916928
41BMX1.11522152
42RET1.10218292
43TYK21.09135005
44MAP2K41.06885422
45CAMKK11.06649356
46NEK11.05613801
47GRK61.04259549
48MAP3K41.04165667
49PDK31.03017572
50PDK41.03017572
51NTRK31.00470806
52DAPK20.99584889
53BLK0.99577274
54MAP3K140.98759377
55PRKD20.95044155
56RPS6KL10.94536232
57RPS6KC10.94536232
58WNK10.93308276
59TAOK30.89972170
60BTK0.89203666
61MAP4K10.87905950
62DYRK1B0.87606140
63CSK0.87235234
64FGFR20.87179100
65SGK30.86872736
66MARK20.85109463
67CDC42BPA0.84822537
68MAP2K20.84392676
69IRAK20.84147226
70FES0.81796596
71DDR20.79432347
72RPS6KA60.78602470
73JAK30.78237328
74CAMK40.77932168
75MAP3K60.76973836
76MAPK70.76410761
77NTRK20.74230839
78MAP2K60.74059762
79UHMK10.72582752
80PDGFRB0.72275217
81NTRK10.72206146
82LRRK20.71087577
83PRKD10.70823987
84PINK10.70705776
85FGFR30.70383615
86* MAP3K10.70112447
87LATS10.67894189
88HIPK20.66648870
89MAP2K30.66297322
90IRAK10.63889429
91PAK30.63313212
92PDK10.63204141
93ARAF0.62941953
94PTK20.62412369
95LATS20.61887820
96PRKAA10.61688888
97SYK0.61342041
98SCYL20.60615305
99NME20.59689702
100IKBKE0.58194159
101FGFR10.56955183
102MARK30.55491389
103JAK20.55275696
104CAMK10.55224937
105MINK10.54940101
106IKBKB0.54896704
107KSR10.54347804
108STK110.52706426
109MAP3K130.51894198
110TXK0.50104112
111JAK10.49747364
112MAP3K80.49315824
113MAP3K110.48695878
114PDPK10.48576272
115PAK20.47724402
116ZAP700.47002966
117EPHA20.46992923
118MAPKAPK30.45892636
119MAPK120.45540643
120CDK60.45454453
121TNK20.44987510
122BRAF0.44786113
123CHUK0.43780722
124DAPK10.43541407
125EPHB10.43409508
126BRD40.42495252
127RPS6KA20.42212258
128RPS6KA30.41540334
129MAPK110.41351543
130RPS6KA10.40880291
131PTK2B0.39901843
132LCK0.39801538
133MAPK100.39246593
134MAPK40.37165014
135MAPKAPK20.37146724
136ITK0.36904553
137EPHA40.36897754
138NEK20.35869548
139HCK0.35796001
140MAPK80.34029430
141CDK40.33127522
142RPS6KB20.30700519
143LYN0.30455628
144MELK0.30093714

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.73815332
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.45314611
3* Osteoclast differentiation_Homo sapiens_hsa043801.89255074
4Other glycan degradation_Homo sapiens_hsa005111.83120819
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77855361
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75717651
7mTOR signaling pathway_Homo sapiens_hsa041501.72091796
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64920454
9Lysine degradation_Homo sapiens_hsa003101.63934494
10Dorso-ventral axis formation_Homo sapiens_hsa043201.58918722
11Arginine biosynthesis_Homo sapiens_hsa002201.54190921
12Primary immunodeficiency_Homo sapiens_hsa053401.53709744
13Dilated cardiomyopathy_Homo sapiens_hsa054141.53426020
14Type II diabetes mellitus_Homo sapiens_hsa049301.52673113
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52655612
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46887226
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46634425
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43218868
19Insulin resistance_Homo sapiens_hsa049311.41012468
20Leishmaniasis_Homo sapiens_hsa051401.38907358
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38790805
22Insulin signaling pathway_Homo sapiens_hsa049101.35187114
23* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34448710
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.33562459
25Glucagon signaling pathway_Homo sapiens_hsa049221.30796433
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30538748
27Glioma_Homo sapiens_hsa052141.27651364
28Long-term potentiation_Homo sapiens_hsa047201.27029444
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.25228741
30Chronic myeloid leukemia_Homo sapiens_hsa052201.25185290
31Insulin secretion_Homo sapiens_hsa049111.19803307
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18270865
33Hepatitis B_Homo sapiens_hsa051611.17422430
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16986642
35Non-small cell lung cancer_Homo sapiens_hsa052231.16902627
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16553541
37Estrogen signaling pathway_Homo sapiens_hsa049151.14862554
38Adipocytokine signaling pathway_Homo sapiens_hsa049201.14561113
39Hepatitis C_Homo sapiens_hsa051601.14440966
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14375188
41VEGF signaling pathway_Homo sapiens_hsa043701.14223986
42Sulfur relay system_Homo sapiens_hsa041221.13965716
43Bile secretion_Homo sapiens_hsa049761.12581784
44Tuberculosis_Homo sapiens_hsa051521.12473450
45Measles_Homo sapiens_hsa051621.11413717
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10907230
47Endometrial cancer_Homo sapiens_hsa052131.10834723
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10662499
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.10261503
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08737283
51Olfactory transduction_Homo sapiens_hsa047401.08344419
52Gastric acid secretion_Homo sapiens_hsa049711.06237199
53Toxoplasmosis_Homo sapiens_hsa051451.06234587
54Oxytocin signaling pathway_Homo sapiens_hsa049211.05049396
55Acute myeloid leukemia_Homo sapiens_hsa052211.04185226
56* Neurotrophin signaling pathway_Homo sapiens_hsa047221.03398526
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02896447
58* TNF signaling pathway_Homo sapiens_hsa046681.02470762
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02339957
60* Influenza A_Homo sapiens_hsa051641.01940781
61Fatty acid biosynthesis_Homo sapiens_hsa000611.01869739
62Chemokine signaling pathway_Homo sapiens_hsa040621.01679882
63AMPK signaling pathway_Homo sapiens_hsa041521.01543100
64Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00166347
65Apoptosis_Homo sapiens_hsa042100.99733386
66Herpes simplex infection_Homo sapiens_hsa051680.98707716
67Circadian entrainment_Homo sapiens_hsa047130.98618433
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98365081
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98189873
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.98135556
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97877379
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96487529
73Thyroid cancer_Homo sapiens_hsa052160.94754402
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93162217
75HTLV-I infection_Homo sapiens_hsa051660.92996212
76Fatty acid degradation_Homo sapiens_hsa000710.92787057
77Salivary secretion_Homo sapiens_hsa049700.91691893
78FoxO signaling pathway_Homo sapiens_hsa040680.91669444
79* GnRH signaling pathway_Homo sapiens_hsa049120.89762249
80Renin secretion_Homo sapiens_hsa049240.87588729
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87368467
82GABAergic synapse_Homo sapiens_hsa047270.86044259
83Synaptic vesicle cycle_Homo sapiens_hsa047210.85154055
84Viral myocarditis_Homo sapiens_hsa054160.84580437
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.84478544
86Prostate cancer_Homo sapiens_hsa052150.83958898
87PPAR signaling pathway_Homo sapiens_hsa033200.83222027
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.83174852
89Biosynthesis of amino acids_Homo sapiens_hsa012300.82329884
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.82179106
91Proteoglycans in cancer_Homo sapiens_hsa052050.82010190
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.81899800
93Malaria_Homo sapiens_hsa051440.81037921
94Amphetamine addiction_Homo sapiens_hsa050310.80591093
95cAMP signaling pathway_Homo sapiens_hsa040240.79713160
96Fatty acid metabolism_Homo sapiens_hsa012120.79478976
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79108868
98Dopaminergic synapse_Homo sapiens_hsa047280.78976294
99Carbon metabolism_Homo sapiens_hsa012000.78239159
100B cell receptor signaling pathway_Homo sapiens_hsa046620.77566005
101* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77141924
102Renal cell carcinoma_Homo sapiens_hsa052110.77091907
103Notch signaling pathway_Homo sapiens_hsa043300.76631342
104Cholinergic synapse_Homo sapiens_hsa047250.76104902
105Focal adhesion_Homo sapiens_hsa045100.75909953
106Gap junction_Homo sapiens_hsa045400.75885228
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75428537
108Prion diseases_Homo sapiens_hsa050200.72980675
109Glutamatergic synapse_Homo sapiens_hsa047240.72650388
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72362210
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.72342598
112Prolactin signaling pathway_Homo sapiens_hsa049170.72129072
113Allograft rejection_Homo sapiens_hsa053300.71095415
114Graft-versus-host disease_Homo sapiens_hsa053320.71023717
115Cocaine addiction_Homo sapiens_hsa050300.70468733
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70302963
117Viral carcinogenesis_Homo sapiens_hsa052030.69957811
118Calcium signaling pathway_Homo sapiens_hsa040200.68755665
119Choline metabolism in cancer_Homo sapiens_hsa052310.66242540
120* Epstein-Barr virus infection_Homo sapiens_hsa051690.65685540
121Autoimmune thyroid disease_Homo sapiens_hsa053200.64947752
122* ErbB signaling pathway_Homo sapiens_hsa040120.64595998
123Morphine addiction_Homo sapiens_hsa050320.63840499
124* MAPK signaling pathway_Homo sapiens_hsa040100.62228178
125Fructose and mannose metabolism_Homo sapiens_hsa000510.61091264
126Colorectal cancer_Homo sapiens_hsa052100.60439008
127HIF-1 signaling pathway_Homo sapiens_hsa040660.60403096
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59642301
129Cardiac muscle contraction_Homo sapiens_hsa042600.59013370
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.58839139
131Inositol phosphate metabolism_Homo sapiens_hsa005620.58799277
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58628141
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58317142
134African trypanosomiasis_Homo sapiens_hsa051430.58113580
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57859862
136Staphylococcus aureus infection_Homo sapiens_hsa051500.57498688
137MicroRNAs in cancer_Homo sapiens_hsa052060.56938861
138Platelet activation_Homo sapiens_hsa046110.56732434
139Bladder cancer_Homo sapiens_hsa052190.56169048
140Pancreatic cancer_Homo sapiens_hsa052120.55863856
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54840375
142Adherens junction_Homo sapiens_hsa045200.54767468
143Pentose phosphate pathway_Homo sapiens_hsa000300.54491851
144Small cell lung cancer_Homo sapiens_hsa052220.54092471
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53203871
146Amoebiasis_Homo sapiens_hsa051460.52789230
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52632793
148Endocytosis_Homo sapiens_hsa041440.52551077
149Melanogenesis_Homo sapiens_hsa049160.50819868
150* T cell receptor signaling pathway_Homo sapiens_hsa046600.50246374
151Rap1 signaling pathway_Homo sapiens_hsa040150.50122297

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