MAP3K1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.40594708
2axon ensheathment in central nervous system (GO:0032291)8.40594708
3positive regulation of gamma-delta T cell activation (GO:0046645)6.59229592
4fatty acid elongation (GO:0030497)6.49443428
5presynaptic membrane assembly (GO:0097105)6.12761158
6regulation of B cell receptor signaling pathway (GO:0050855)5.64954912
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.64161979
8negative regulation of cell killing (GO:0031342)5.64161979
9negative regulation of execution phase of apoptosis (GO:1900118)5.53214374
10presynaptic membrane organization (GO:0097090)5.49378734
11short-term memory (GO:0007614)5.41024087
12positive regulation of protein kinase C signaling (GO:0090037)5.40862859
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.33100493
14glycogen catabolic process (GO:0005980)5.28164490
15glucan catabolic process (GO:0009251)5.02684592
16regulation of gamma-delta T cell activation (GO:0046643)4.98942905
17negative regulation of transcription by competitive promoter binding (GO:0010944)4.93385266
18regulation of gamma-delta T cell differentiation (GO:0045586)4.82036543
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.81543692
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.81543692
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.81543692
22modulation by symbiont of host immune response (GO:0052553)4.81543692
23positive regulation by symbiont of host defense response (GO:0052509)4.81543692
24modulation by symbiont of host defense response (GO:0052031)4.81543692
25limb bud formation (GO:0060174)4.66014954
26cellular polysaccharide catabolic process (GO:0044247)4.58326582
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.58161299
28polysaccharide catabolic process (GO:0000272)4.51075279
29postsynaptic membrane organization (GO:0001941)4.50336194
30detection of other organism (GO:0098543)4.45432023
31antigen processing and presentation of endogenous antigen (GO:0019883)4.32498603
32negative thymic T cell selection (GO:0045060)4.31358061
33negative T cell selection (GO:0043383)4.30565590
34neutrophil activation involved in immune response (GO:0002283)4.28154971
35macrophage activation involved in immune response (GO:0002281)4.26912148
36B cell receptor signaling pathway (GO:0050853)4.22834903
37detection of molecule of bacterial origin (GO:0032490)4.21910486
38negative regulation of T cell mediated immunity (GO:0002710)4.15345746
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14878073
40cellular extravasation (GO:0045123)4.14491757
41oligodendrocyte differentiation (GO:0048709)4.08742149
42detection of bacterium (GO:0016045)4.05884328
43positive T cell selection (GO:0043368)4.02988262
44positive regulation of cellular amine metabolic process (GO:0033240)3.98599319
45positive thymic T cell selection (GO:0045059)3.98338262
46microglial cell activation (GO:0001774)3.96741521
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.95578899
48detection of external biotic stimulus (GO:0098581)3.94326943
49axon ensheathment (GO:0008366)3.93474090
50ensheathment of neurons (GO:0007272)3.93474090
51myelination (GO:0042552)3.90792836
52regulation of B cell differentiation (GO:0045577)3.84747891
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.83422120
54response to peptidoglycan (GO:0032494)3.78857376
55positive regulation of B cell differentiation (GO:0045579)3.77725762
56histone H3-K36 demethylation (GO:0070544)3.77447794
57T cell selection (GO:0045058)3.74884739
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74390009
59retina layer formation (GO:0010842)3.71698136
60centriole replication (GO:0007099)3.70973885
61positive regulation of granulocyte differentiation (GO:0030854)3.67807933
62leukocyte aggregation (GO:0070486)3.66368486
63activated T cell proliferation (GO:0050798)3.61814784
64metanephric nephron tubule development (GO:0072234)3.61611895
65metanephric tubule development (GO:0072170)3.61611895
66negative regulation of keratinocyte proliferation (GO:0010839)3.60921035
67regulation of interferon-beta biosynthetic process (GO:0045357)3.58925481
68long-chain fatty acid biosynthetic process (GO:0042759)3.55565389
69lymphoid progenitor cell differentiation (GO:0002320)3.54208041
70tongue development (GO:0043586)3.53645935
71detection of biotic stimulus (GO:0009595)3.52266194
72regulation of pigment cell differentiation (GO:0050932)3.50306985
73macrophage activation (GO:0042116)3.48647572
74hepatocyte apoptotic process (GO:0097284)3.48114657
75response to folic acid (GO:0051593)3.48068072
76nephron epithelium development (GO:0072009)3.46770425
77melanin metabolic process (GO:0006582)3.45074591
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.44789955
79negative regulation of myotube differentiation (GO:0010832)3.42756408
80response to interleukin-15 (GO:0070672)3.42735245
81negative regulation of interleukin-12 production (GO:0032695)3.41409844
82organ growth (GO:0035265)3.40434020
83neutrophil activation (GO:0042119)3.37320896
84T cell migration (GO:0072678)3.35573360
85neuron cell-cell adhesion (GO:0007158)3.35103626
86melanin biosynthetic process (GO:0042438)3.33642602
87response to host immune response (GO:0052572)3.33259803
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33259803
89response to muramyl dipeptide (GO:0032495)3.33123254
90negative regulation of protein localization to cell surface (GO:2000009)3.31130568
91production of molecular mediator involved in inflammatory response (GO:0002532)3.30623288
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30163653
93phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.30058294
94regulation of alpha-beta T cell proliferation (GO:0046640)3.29912445
95myeloid cell activation involved in immune response (GO:0002275)3.29022782
96thymic T cell selection (GO:0045061)3.27413202
97positive regulation of glycogen metabolic process (GO:0070875)3.25166089
98GMP metabolic process (GO:0046037)3.25165575
99metanephric nephron epithelium development (GO:0072243)3.23213196
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.21290145
101negative regulation of leukocyte mediated immunity (GO:0002704)3.21000134
102tolerance induction (GO:0002507)3.20709357
103eye photoreceptor cell differentiation (GO:0001754)3.17743607
104photoreceptor cell differentiation (GO:0046530)3.17743607
105cellular carbohydrate catabolic process (GO:0044275)3.17168001
106antigen processing and presentation via MHC class Ib (GO:0002475)3.15976288
107interferon-gamma production (GO:0032609)3.15141948
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.13996828
109response to host (GO:0075136)3.12624439
110response to host defenses (GO:0052200)3.12624439
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12624439
112immunoglobulin mediated immune response (GO:0016064)3.11723605
113regulation of tolerance induction (GO:0002643)3.11244301
114endothelium development (GO:0003158)3.09926163
115myeloid leukocyte mediated immunity (GO:0002444)3.08520053
116facial nerve structural organization (GO:0021612)3.07831144
117mesonephros development (GO:0001823)3.06496671
118negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.06429056
119regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.05504545
120positive regulation of mast cell activation (GO:0033005)3.05151092
121regulation of T cell tolerance induction (GO:0002664)3.05080269
122cellular response to interleukin-15 (GO:0071350)3.03750821
123metanephric epithelium development (GO:0072207)3.03441827
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02564240
125developmental pigmentation (GO:0048066)3.00373120
126positive regulation of alpha-beta T cell proliferation (GO:0046641)2.99734288
127granulocyte activation (GO:0036230)2.99699220
128negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.99001379
129negative regulation of T-helper cell differentiation (GO:0045623)2.98552460
130negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98552460
131negative regulation of erythrocyte differentiation (GO:0045647)2.98445130
132defense response to protozoan (GO:0042832)2.95904356
133positive regulation of interferon-alpha production (GO:0032727)2.95653276
134regulation of regulatory T cell differentiation (GO:0045589)2.94171765
135negative regulation of adaptive immune response (GO:0002820)2.94050902
136nephron tubule development (GO:0072080)2.93950411
137GPI anchor biosynthetic process (GO:0006506)2.93330228
138respiratory burst (GO:0045730)2.92880144
139positive regulation of calcium ion import (GO:0090280)2.92106111
140calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.91458876
141neuron remodeling (GO:0016322)2.91028375
142secondary metabolite biosynthetic process (GO:0044550)2.90767082
143antigen receptor-mediated signaling pathway (GO:0050851)2.90261057
144hemidesmosome assembly (GO:0031581)2.90113483
145dendritic cell migration (GO:0036336)2.90044294
146negative regulation of B cell proliferation (GO:0030889)2.89651315
147very long-chain fatty acid metabolic process (GO:0000038)2.88557719
148regulation of mast cell degranulation (GO:0043304)2.88386568
149cranial nerve morphogenesis (GO:0021602)2.88239146
150protein heterotetramerization (GO:0051290)2.88174694
151UV protection (GO:0009650)2.83493212
152enteric nervous system development (GO:0048484)2.81487206
153regulation of mast cell activation (GO:0033003)2.80455894
154membrane assembly (GO:0071709)2.79215050
155cranial nerve structural organization (GO:0021604)2.78728259
156regulation of somitogenesis (GO:0014807)2.77366068
157B cell homeostasis (GO:0001782)2.74278374
158regulation of mast cell activation involved in immune response (GO:0033006)2.73703090
159regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.73460299
160myelin maintenance (GO:0043217)2.73181244
161GPI anchor metabolic process (GO:0006505)2.72886475
162positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.72270112
163regulation of interferon-alpha production (GO:0032647)2.72095108
164regulation of timing of cell differentiation (GO:0048505)2.71538569
165ribosomal small subunit biogenesis (GO:0042274)2.70712841
166glycogen biosynthetic process (GO:0005978)2.68927422
167glucan biosynthetic process (GO:0009250)2.68927422
168response to methylmercury (GO:0051597)2.68366445
169regulation of granulocyte differentiation (GO:0030852)2.67390055
170interferon-gamma-mediated signaling pathway (GO:0060333)2.67020237
171positive regulation of tolerance induction (GO:0002645)2.67017375
172regulation of protein kinase C signaling (GO:0090036)2.66652694
173mRNA modification (GO:0016556)2.66596480
174regulation of protein kinase A signaling (GO:0010738)2.65768390
175import into cell (GO:0098657)2.64022462
176androgen biosynthetic process (GO:0006702)2.63883020
177sympathetic nervous system development (GO:0048485)2.62166918
178omega-hydroxylase P450 pathway (GO:0097267)2.61978450
179positive regulation of oligodendrocyte differentiation (GO:0048714)2.58952142
180neuronal action potential propagation (GO:0019227)2.58372043
181long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.57823523
182oligosaccharide catabolic process (GO:0009313)2.57198744
183polyol transport (GO:0015791)2.55676316
184cranial nerve development (GO:0021545)2.54740479
185renal tubule development (GO:0061326)2.51634801
186glial cell differentiation (GO:0010001)2.51321928
187centriole assembly (GO:0098534)2.51078329
188positive regulation of protein tyrosine kinase activity (GO:0061098)2.50451754
189cholesterol biosynthetic process (GO:0006695)2.50300722
190negative regulation of granulocyte differentiation (GO:0030853)2.50243940
191neutrophil mediated immunity (GO:0002446)2.49648153
192otic vesicle formation (GO:0030916)2.47793407
193long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.46713242
194mannosylation (GO:0097502)2.45484944
195regulation of non-canonical Wnt signaling pathway (GO:2000050)2.44840838
196negative regulation of interleukin-10 production (GO:0032693)2.43099472
197branch elongation of an epithelium (GO:0060602)2.42292888
198mesenchymal cell differentiation involved in renal system development (GO:2001012)2.41196431
199mesenchymal cell differentiation involved in kidney development (GO:0072161)2.41196431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.07360283
2EZH2_22144423_ChIP-Seq_EOC_Human6.01468996
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.51764067
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.87393814
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.00333555
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.46286692
7RUNX_20019798_ChIP-Seq_JUKART_Human3.37425537
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.36841867
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34954781
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18009581
11* IRF8_27001747_Chip-Seq_BMDM_Mouse3.06189128
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.04032065
13TAF15_26573619_Chip-Seq_HEK293_Human2.95427086
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.87731228
15MYB_26560356_Chip-Seq_TH2_Human2.81485966
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81212701
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80489660
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77961592
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.73829643
20SCL_19346495_ChIP-Seq_HPC-7_Human2.65947369
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.60690729
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56314706
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.55689409
24AR_21572438_ChIP-Seq_LNCaP_Human2.48539584
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46590267
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43260320
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.37871303
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35118292
29TP63_17297297_ChIP-ChIP_HaCaT_Human2.34401817
30MYB_26560356_Chip-Seq_TH1_Human2.33991973
31* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31321450
32JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30097562
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29633477
34BP1_19119308_ChIP-ChIP_Hs578T_Human2.28744085
35GATA1_22025678_ChIP-Seq_K562_Human2.28217145
36* SPI1_23547873_ChIP-Seq_NB4_Human2.27995654
37EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27945722
38RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27945722
39GBX2_23144817_ChIP-Seq_PC3_Human2.26142383
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18908190
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17334042
42EGR1_19374776_ChIP-ChIP_THP-1_Human2.16919519
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13464908
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13130603
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12779920
46* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.10939380
47BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10051204
48* VDR_24787735_ChIP-Seq_THP-1_Human2.08397436
49* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.08124185
50PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06943864
51* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04591935
52VDR_22108803_ChIP-Seq_LS180_Human2.02688931
53IRF1_19129219_ChIP-ChIP_H3396_Human2.02506556
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.99467029
55GATA3_27048872_Chip-Seq_THYMUS_Human1.95035130
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93672575
57* MAF_26560356_Chip-Seq_TH1_Human1.93468490
58SPI1_23127762_ChIP-Seq_K562_Human1.92614897
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91980334
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91558227
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89447458
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.89406963
63* VDR_24763502_ChIP-Seq_THP-1_Human1.86815665
64MYC_22102868_ChIP-Seq_BL_Human1.76611688
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74928408
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72813223
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72614647
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72149305
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.67722468
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67216476
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64601499
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.64196235
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63880277
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63109562
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.62447226
76* TCF7_22412390_ChIP-Seq_EML_Mouse1.62167991
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60263321
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.59048146
79* UTX_26944678_Chip-Seq_JUKART_Human1.58547353
80PU_27001747_Chip-Seq_BMDM_Mouse1.58507604
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58334585
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.58017267
83RNF2_27304074_Chip-Seq_NSC_Mouse1.56511507
84GATA3_26560356_Chip-Seq_TH2_Human1.56176123
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56096942
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53223067
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51821308
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51513877
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50462178
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.47776697
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.44655128
92ER_23166858_ChIP-Seq_MCF-7_Human1.44633976
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40311222
94VDR_21846776_ChIP-Seq_THP-1_Human1.37103334
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.35968515
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34463439
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.33086475
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32935717
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32564051
100* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32406977
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30866988
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30644602
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.29379150
104P300_18555785_Chip-Seq_ESCs_Mouse1.29154697
105P300_19829295_ChIP-Seq_ESCs_Human1.29020017
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.28850183
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28049635
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26394545
109RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24952130
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.24572638
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22288965
112IGF1R_20145208_ChIP-Seq_DFB_Human1.21804895
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21129797
114P53_22387025_ChIP-Seq_ESCs_Mouse1.21093619
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17696726
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.15381083
117MAF_26560356_Chip-Seq_TH2_Human1.15034983
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.14877084
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13868234
120FOXO3_23340844_ChIP-Seq_DLD1_Human1.13634590
121STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11827909
122* GATA1_19941827_ChIP-Seq_MEL_Mouse1.11759291
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11672065
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.11646598
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09728880
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08790546
127CDX2_20551321_ChIP-Seq_CACO-2_Human1.08480005
128* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08260600
129NMYC_18555785_Chip-Seq_ESCs_Mouse1.07666332
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.07659987
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.06552611
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06268383
133GATA2_19941826_ChIP-Seq_K562_Human1.05304381
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04947868
135GATA1_19941826_ChIP-Seq_K562_Human1.04795374
136SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04597940
137* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04204851
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04091676
139FUS_26573619_Chip-Seq_HEK293_Human1.04034567
140* RUNX2_22187159_ChIP-Seq_PCA_Human1.03863125
141KLF4_18555785_Chip-Seq_ESCs_Mouse1.02981874
142KDM2B_26808549_Chip-Seq_DND41_Human1.02720279
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02245254
144GATA2_21666600_ChIP-Seq_HMVEC_Human1.01704557
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.01619274
146SOX2_18555785_Chip-Seq_ESCs_Mouse1.00921481
147* KDM2B_26808549_Chip-Seq_REH_Human1.00015289
148* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99275225
149* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99149457
150* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98133674
151OCT4_18555785_Chip-Seq_ESCs_Mouse0.97737738
152KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96914663
153KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96914663
154KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96914663
155* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96345480
156* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95806062
157MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95596992
158PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94928857
159* SMRT_27268052_Chip-Seq_Bcells_Human0.94726365
160ZFX_18555785_Chip-Seq_ESCs_Mouse0.94610694
161ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94058310
162AHR_22903824_ChIP-Seq_MCF-7_Human0.93521979
163EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93376241
164PU1_27457419_Chip-Seq_LIVER_Mouse0.93274038
165* TP53_18474530_ChIP-ChIP_U2OS_Human0.92407367
166VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92401092
167* SMAD4_21799915_ChIP-Seq_A2780_Human0.91065581
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90943660
169CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89017282
170SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88746487
171ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88152188
172SALL1_21062744_ChIP-ChIP_HESCs_Human0.88071495
173NOTCH1_21737748_ChIP-Seq_TLL_Human0.86694889
174SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86466659
175* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86208695
176KDM2B_26808549_Chip-Seq_JURKAT_Human0.83291715
177CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82739841
178GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82022337
179FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80369718
180GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78081374
181FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77966151
182LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77737544
183CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73940981
184GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73773179
185CIITA_25753668_ChIP-Seq_RAJI_Human0.73018485
186ARNT_22903824_ChIP-Seq_MCF-7_Human0.72112624
187VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69042549
188GATA3_26560356_Chip-Seq_TH1_Human0.67785514
189PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67656386
190* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66969760
191TFEB_21752829_ChIP-Seq_HELA_Human0.65424967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.51932223
2MP0005409_darkened_coat_color6.19906492
3MP0004381_abnormal_hair_follicle5.85403278
4MP0009379_abnormal_foot_pigmentation4.92678517
5MP0001188_hyperpigmentation4.34905572
6MP0001835_abnormal_antigen_presentation3.79691065
7MP0003763_abnormal_thymus_physiology3.33414688
8MP0003436_decreased_susceptibility_to3.01491958
9MP0001800_abnormal_humoral_immune2.98593887
10MP0000920_abnormal_myelination2.87277006
11MP0003880_abnormal_central_pattern2.83598456
12MP0002009_preneoplasia2.82711696
13MP0005671_abnormal_response_to2.67950442
14MP0005174_abnormal_tail_pigmentation2.66408047
15MP0000569_abnormal_digit_pigmentation2.62192431
16MP0000685_abnormal_immune_system2.46707566
17MP0003300_gastrointestinal_ulcer2.45951902
18MP0002166_altered_tumor_susceptibility2.44435650
19MP0003724_increased_susceptibility_to2.42103682
20MP0005387_immune_system_phenotype2.42049170
21MP0001790_abnormal_immune_system2.42049170
22MP0002723_abnormal_immune_serum2.41870639
23MP0002452_abnormal_antigen_presenting2.41772607
24MP0002420_abnormal_adaptive_immunity2.40452286
25MP0001819_abnormal_immune_cell2.36899936
26MP0000015_abnormal_ear_pigmentation2.35748653
27MP0005025_abnormal_response_to2.31729730
28MP0008057_abnormal_DNA_replication2.28064311
29MP0004742_abnormal_vestibular_system2.25577926
30MP0003828_pulmonary_edema2.16653289
31MP0002398_abnormal_bone_marrow2.08366522
32MP0009785_altered_susceptibility_to2.07910305
33MP0004142_abnormal_muscle_tone2.05779359
34MP0000566_synostosis2.03281966
35MP0002405_respiratory_system_inflammati1.96689478
36MP0005464_abnormal_platelet_physiology1.92741423
37MP0002396_abnormal_hematopoietic_system1.92186427
38MP0000716_abnormal_immune_system1.91571119
39MP0005171_absent_coat_pigmentation1.87419890
40MP0002095_abnormal_skin_pigmentation1.83845350
41MP0000689_abnormal_spleen_morphology1.83506820
42MP0005423_abnormal_somatic_nervous1.82761331
43MP0000383_abnormal_hair_follicle1.79927452
44MP0003172_abnormal_lysosome_physiology1.75401374
45MP0005310_abnormal_salivary_gland1.74855547
46MP0000703_abnormal_thymus_morphology1.74752688
47MP0005075_abnormal_melanosome_morpholog1.74086508
48MP0004947_skin_inflammation1.73764307
49MP0006082_CNS_inflammation1.73435051
50MP0002722_abnormal_immune_system1.72875836
51MP0009333_abnormal_splenocyte_physiolog1.68073075
52MP0003191_abnormal_cellular_cholesterol1.66428338
53MP0001346_abnormal_lacrimal_gland1.65839211
54MP0010155_abnormal_intestine_physiology1.61318740
55MP0001486_abnormal_startle_reflex1.57724851
56MP0002006_tumorigenesis1.57357140
57MP0000613_abnormal_salivary_gland1.56889482
58MP0002429_abnormal_blood_cell1.50795120
59MP0001845_abnormal_inflammatory_respons1.49575507
60MP0000762_abnormal_tongue_morphology1.46581026
61MP0000579_abnormal_nail_morphology1.46180632
62MP0005451_abnormal_body_composition1.45102238
63MP0003011_delayed_dark_adaptation1.44902876
64MP0003938_abnormal_ear_development1.44626921
65MP0002102_abnormal_ear_morphology1.43322671
66MP0003183_abnormal_peptide_metabolism1.39245952
67MP0001533_abnormal_skeleton_physiology1.38532967
68MP0006292_abnormal_olfactory_placode1.30590716
69MP0000467_abnormal_esophagus_morphology1.30105277
70MP0004808_abnormal_hematopoietic_stem1.26770190
71MP0001873_stomach_inflammation1.26726787
72MP0004264_abnormal_extraembryonic_tissu1.24827133
73MP0001299_abnormal_eye_distance/1.22816800
74MP0010678_abnormal_skin_adnexa1.22311062
75MP0005397_hematopoietic_system_phenotyp1.21711534
76MP0001545_abnormal_hematopoietic_system1.21711534
77MP0002751_abnormal_autonomic_nervous1.21321808
78MP0001905_abnormal_dopamine_level1.20863368
79* MP0004883_abnormal_blood_vessel1.20212530
80MP0003941_abnormal_skin_development1.18322579
81MP0002249_abnormal_larynx_morphology1.17108693
82MP0002277_abnormal_respiratory_mucosa1.16997746
83MP0003656_abnormal_erythrocyte_physiolo1.16853416
84MP0002132_abnormal_respiratory_system1.15857104
85MP0002272_abnormal_nervous_system1.15509528
86MP0009278_abnormal_bone_marrow1.15032775
87MP0002177_abnormal_outer_ear1.14071089
88MP0009046_muscle_twitch1.11491646
89MP0008260_abnormal_autophagy1.11013165
90MP0000778_abnormal_nervous_system1.10762636
91MP0001968_abnormal_touch/_nociception1.09072372
92MP0002734_abnormal_mechanical_nocicepti1.07506438
93MP0002998_abnormal_bone_remodeling1.06454197
94MP0003303_peritoneal_inflammation1.05973595
95MP0008469_abnormal_protein_level1.02688404
96MP0002138_abnormal_hepatobiliary_system1.01117369
97MP0003045_fibrosis1.00031450
98MP0009384_cardiac_valve_regurgitation0.96624737
99MP0002067_abnormal_sensory_capabilities0.96351428
100MP0003632_abnormal_nervous_system0.95527579
101MP0005551_abnormal_eye_electrophysiolog0.93770982
102MP0000026_abnormal_inner_ear0.92530594
103MP0003950_abnormal_plasma_membrane0.92054153
104MP0003787_abnormal_imprinting0.91810979
105* MP0001853_heart_inflammation0.90608424
106MP0001970_abnormal_pain_threshold0.88898897
107MP0005083_abnormal_biliary_tract0.88177544
108MP0002752_abnormal_somatic_nervous0.86912260
109MP0005076_abnormal_cell_differentiation0.86560500
110MP0002229_neurodegeneration0.86069098
111MP0000371_diluted_coat_color0.85814326
112MP0003634_abnormal_glial_cell0.85527986
113MP0000049_abnormal_middle_ear0.84360265
114MP0003690_abnormal_glial_cell0.83493510
115MP0008004_abnormal_stomach_pH0.83347811
116MP0005408_hypopigmentation0.82421617
117* MP0000858_altered_metastatic_potential0.82327044
118* MP0001340_abnormal_eyelid_morphology0.81866310
119MP0000647_abnormal_sebaceous_gland0.80329270
120MP0002938_white_spotting0.79911012
121MP0001529_abnormal_vocalization0.79557591
122MP0002098_abnormal_vibrissa_morphology0.79203893
123MP0009745_abnormal_behavioral_response0.78941555
124MP0003866_abnormal_defecation0.78646565
125MP0001963_abnormal_hearing_physiology0.76670562
126* MP0005164_abnormal_response_to0.75792114
127MP0005195_abnormal_posterior_eye0.74731990
128MP0002933_joint_inflammation0.74069630
129MP0002064_seizures0.73317542
130MP0001986_abnormal_taste_sensitivity0.73110822
131* MP0003091_abnormal_cell_migration0.72329722
132MP0005379_endocrine/exocrine_gland_phen0.72255293
133MP0005058_abnormal_lysosome_morphology0.72000433
134MP0003959_abnormal_lean_body0.70788814
135MP0000631_abnormal_neuroendocrine_gland0.70433653
136MP0000465_gastrointestinal_hemorrhage0.69526894
137MP0004885_abnormal_endolymph0.69149333
138MP0002876_abnormal_thyroid_physiology0.68847814
139MP0003453_abnormal_keratinocyte_physiol0.68701523
140MP0006276_abnormal_autonomic_nervous0.68460206
141* MP0002019_abnormal_tumor_incidence0.68406692
142MP0009115_abnormal_fat_cell0.67388335
143MP0001177_atelectasis0.65532282
144MP0005166_decreased_susceptibility_to0.65279842
145MP0008995_early_reproductive_senescence0.64424545
146MP0000377_abnormal_hair_follicle0.64245711
147MP0001485_abnormal_pinna_reflex0.63594726
148MP0001502_abnormal_circadian_rhythm0.63340741
149* MP0000249_abnormal_blood_vessel0.63270052
150MP0002796_impaired_skin_barrier0.62928155
151MP0002282_abnormal_trachea_morphology0.62140232
152* MP0003448_altered_tumor_morphology0.61610480
153* MP0004484_altered_response_of0.61447121
154MP0002254_reproductive_system_inflammat0.61384559
155MP0006054_spinal_hemorrhage0.61167546
156MP0002882_abnormal_neuron_morphology0.60665346
157MP0001661_extended_life_span0.60595663
158* MP0009763_increased_sensitivity_to0.60130076
159MP0009250_abnormal_appendicular_skeleto0.60123104
160MP0002928_abnormal_bile_duct0.59437308
161MP0009764_decreased_sensitivity_to0.59399558
162MP0009765_abnormal_xenobiotic_induced0.59316569
163MP0004130_abnormal_muscle_cell0.58814041
164MP0010234_abnormal_vibrissa_follicle0.58658039
165MP0004270_analgesia0.57341253
166MP0001851_eye_inflammation0.56610576
167MP0006072_abnormal_retinal_apoptosis0.55597396
168MP0002735_abnormal_chemical_nociception0.55481505
169MP0005000_abnormal_immune_tolerance0.53648742
170MP0005388_respiratory_system_phenotype0.53071598
171MP0002133_abnormal_respiratory_system0.53071598
172MP0003937_abnormal_limbs/digits/tail_de0.52760776
173MP0005381_digestive/alimentary_phenotyp0.49453669
174MP0002419_abnormal_innate_immunity0.48038947
175MP0001216_abnormal_epidermal_layer0.47362416
176MP0002148_abnormal_hypersensitivity_rea0.47191818

Predicted human phenotypes

RankGene SetZ-score
1Abnormal biliary tract physiology (HP:0012439)7.02044243
2Bile duct proliferation (HP:0001408)7.02044243
3Obstructive sleep apnea (HP:0002870)5.98951156
4Alacrima (HP:0000522)5.85082071
5Eczematoid dermatitis (HP:0000976)5.76877193
6Recurrent bacterial skin infections (HP:0005406)5.50443306
7Recurrent abscess formation (HP:0002722)5.08798989
8Decreased lacrimation (HP:0000633)4.88528826
9Parakeratosis (HP:0001036)4.84850665
10T lymphocytopenia (HP:0005403)4.50584753
11Myositis (HP:0100614)4.30257984
12Retrobulbar optic neuritis (HP:0100654)4.19405656
13Optic neuritis (HP:0100653)4.19405656
14Abnormality of T cell number (HP:0011839)4.17601057
15Recurrent fungal infections (HP:0002841)4.15993365
16Orchitis (HP:0100796)4.02181488
17Mediastinal lymphadenopathy (HP:0100721)3.85137176
18Recurrent skin infections (HP:0001581)3.85124172
19Prolonged partial thromboplastin time (HP:0003645)3.84132411
20Abnormality of macrophages (HP:0004311)3.80819408
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.79066761
22Elevated erythrocyte sedimentation rate (HP:0003565)3.73534305
23Recurrent cutaneous fungal infections (HP:0011370)3.68353523
24Chronic mucocutaneous candidiasis (HP:0002728)3.68353523
25Recurrent gram-negative bacterial infections (HP:0005420)3.64272404
26Gastrointestinal infarctions (HP:0005244)3.63025863
27Sleep apnea (HP:0010535)3.55871842
28Recurrent viral infections (HP:0004429)3.46772909
29Spontaneous hematomas (HP:0007420)3.40935657
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.35214134
31Gingivitis (HP:0000230)3.26191349
32Vasculitis (HP:0002633)3.21759385
33Keratoconjunctivitis sicca (HP:0001097)3.19967006
34Peripheral hypomyelination (HP:0007182)3.17513481
35Abnormality of T cells (HP:0002843)3.09740541
36Agammaglobulinemia (HP:0004432)3.04270684
37Colitis (HP:0002583)3.01006687
38Pulmonary infiltrates (HP:0002113)3.00938924
39Chest pain (HP:0100749)2.99618469
40Panhypogammaglobulinemia (HP:0003139)2.98741584
41Encephalitis (HP:0002383)2.96832024
42Keratoconjunctivitis (HP:0001096)2.96454154
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.92785859
44Split foot (HP:0001839)2.92542498
45Reduced antithrombin III activity (HP:0001976)2.91645113
46Gingival bleeding (HP:0000225)2.88848921
47Leukocytosis (HP:0001974)2.88450284
48Prolonged bleeding time (HP:0003010)2.88233497
49Attenuation of retinal blood vessels (HP:0007843)2.86955686
50Pustule (HP:0200039)2.85880406
51Hemoptysis (HP:0002105)2.85813683
52Inflammation of the large intestine (HP:0002037)2.84575662
53Sensory axonal neuropathy (HP:0003390)2.81239242
54Increased IgE level (HP:0003212)2.79566086
55Subacute progressive viral hepatitis (HP:0006572)2.79492778
56Optic nerve hypoplasia (HP:0000609)2.78984062
57Optic disc pallor (HP:0000543)2.78702528
58Arterial thrombosis (HP:0004420)2.77690255
59Viral hepatitis (HP:0006562)2.76448939
60White forelock (HP:0002211)2.75964109
61Esotropia (HP:0000565)2.75526336
62Autoimmune hemolytic anemia (HP:0001890)2.69839705
63Gastrointestinal inflammation (HP:0004386)2.68737023
64Septo-optic dysplasia (HP:0100842)2.68029759
65Cellulitis (HP:0100658)2.63191393
66Laryngomalacia (HP:0001601)2.60381582
67Urticaria (HP:0001025)2.59851129
68Epistaxis (HP:0000421)2.59455741
69Absent septum pellucidum (HP:0001331)2.58644819
70Absent speech (HP:0001344)2.54165965
71Patchy hypopigmentation of hair (HP:0011365)2.54164987
72Recurrent bronchitis (HP:0002837)2.54145643
73Thyroid-stimulating hormone excess (HP:0002925)2.53254480
74Granulocytopenia (HP:0001913)2.50669311
75Hematochezia (HP:0002573)2.49584045
76* Abnormality of secondary sexual hair (HP:0009888)2.49027411
77* Abnormality of the axillary hair (HP:0100134)2.49027411
78Osteomyelitis (HP:0002754)2.48925279
79Eosinophilia (HP:0001880)2.48401407
80IgM deficiency (HP:0002850)2.45082233
81Pulmonary embolism (HP:0002204)2.44529304
82Type I transferrin isoform profile (HP:0003642)2.42429673
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40017044
84Delayed myelination (HP:0012448)2.39511630
85Gangrene (HP:0100758)2.38350174
86Neurofibrillary tangles (HP:0002185)2.37574549
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37216867
88Degeneration of the lateral corticospinal tracts (HP:0002314)2.37216867
89Neoplasm of the tracheobronchial system (HP:0100552)2.36957866
90Ocular albinism (HP:0001107)2.35742853
91Verrucae (HP:0200043)2.33847793
92Papilloma (HP:0012740)2.33847793
93Renal Fanconi syndrome (HP:0001994)2.32504918
94Abnormality of the septum pellucidum (HP:0007375)2.32336983
95Abnormality of T cell physiology (HP:0011840)2.31146571
96Short tibia (HP:0005736)2.30972228
97Abnormality of the fingertips (HP:0001211)2.30594852
98Lymphopenia (HP:0001888)2.29968617
99Papilledema (HP:0001085)2.28696564
100Periodontitis (HP:0000704)2.27579439
101Ketosis (HP:0001946)2.27265816
102Abnormality of eosinophils (HP:0001879)2.25831462
103Chin dimple (HP:0010751)2.25106559
104Joint hemorrhage (HP:0005261)2.23378108
105Increased hepatocellular lipid droplets (HP:0006565)2.22929427
106Cupped ear (HP:0000378)2.21265153
107Aplasia/Hypoplasia of the tibia (HP:0005772)2.20728902
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19775203
109Atrophic scars (HP:0001075)2.19182352
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19007025
111Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14838001
112Abnormality of the peritoneum (HP:0002585)2.13769684
113Spastic paraparesis (HP:0002313)2.13313056
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.12690413
115Abnormality of the pleura (HP:0002103)2.10791336
116Abnormality of magnesium homeostasis (HP:0004921)2.10789811
117Concave nail (HP:0001598)2.10224503
118Limited hip movement (HP:0008800)2.09833190
119Intrahepatic cholestasis (HP:0001406)2.08215814
120Stomach cancer (HP:0012126)2.07921646
121Hypoplasia of the thymus (HP:0000778)2.07532784
122Papillary thyroid carcinoma (HP:0002895)2.06567330
123Stomatitis (HP:0010280)2.06420148
124Sepsis (HP:0100806)2.05754259
125Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05301198
126Hypomagnesemia (HP:0002917)2.04873892
127Alveolar cell carcinoma (HP:0006519)2.03774118
128Anorexia (HP:0002039)2.02892398
129Episodic fever (HP:0001954)2.01566800
130Partial duplication of thumb phalanx (HP:0009944)2.01223814
131Meningitis (HP:0001287)2.01181242
132Short chin (HP:0000331)2.00720582
133Iris hypopigmentation (HP:0007730)2.00367648
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.99670620
135Absent/shortened dynein arms (HP:0200106)1.99670620
136Obstructive lung disease (HP:0006536)1.99438756
137Chronic obstructive pulmonary disease (HP:0006510)1.99438756
138Bifid scrotum (HP:0000048)1.97291914
139Hypertriglyceridemia (HP:0002155)1.97135647
140Fatigue (HP:0012378)1.96956961
141Amaurosis fugax (HP:0100576)1.96744104
142Lipid accumulation in hepatocytes (HP:0006561)1.94719812
143Conjunctival telangiectasia (HP:0000524)1.94578408
144Onion bulb formation (HP:0003383)1.94455866
145Abnormality of the prostate (HP:0008775)1.92748075
146Partial agenesis of the corpus callosum (HP:0001338)1.91476697
147Hypoplastic pelvis (HP:0008839)1.89889846
148Skin ulcer (HP:0200042)1.89338007
149Hypoplasia of the iris (HP:0007676)1.89300602
150Chronic diarrhea (HP:0002028)1.89144993
151Overfolded helix (HP:0000396)1.87869501
152Hypoplasia of the ulna (HP:0003022)1.87478896
153Asplenia (HP:0001746)1.87176142
154Severe combined immunodeficiency (HP:0004430)1.85758489
155Anomalous pulmonary venous return (HP:0010772)1.84659579
156Bradycardia (HP:0001662)1.84478397
157Congenital ichthyosiform erythroderma (HP:0007431)1.84304463
158Peritonitis (HP:0002586)1.83126318
159Glomerulopathy (HP:0100820)1.82154715
160Thyroiditis (HP:0100646)1.82103101
161Abnormality of the pulmonary veins (HP:0011718)1.81372072
162IgG deficiency (HP:0004315)1.80855355
163Gastrointestinal stroma tumor (HP:0100723)1.80242558
164Thrombophlebitis (HP:0004418)1.79999602
165Prolonged neonatal jaundice (HP:0006579)1.79420857
166Renal agenesis (HP:0000104)1.78441058
167Hypochromic microcytic anemia (HP:0004840)1.78030290
168Morphological abnormality of the inner ear (HP:0011390)1.77991025
169Conjugated hyperbilirubinemia (HP:0002908)1.77846639
170Micronodular cirrhosis (HP:0001413)1.77573442
171Macrocytic anemia (HP:0001972)1.77411394
172Annular pancreas (HP:0001734)1.77206307
173Amyloidosis (HP:0011034)1.76562537
174Generalized hypotonia (HP:0001290)1.76452434
175Partial duplication of the phalanx of hand (HP:0009999)1.74655180
176Abnormal ciliary motility (HP:0012262)1.73564025
177Polyneuropathy (HP:0001271)1.72904178
178Hypophosphatemic rickets (HP:0004912)1.71522526
179Acute hepatic failure (HP:0006554)1.71121918
180Flat occiput (HP:0005469)1.69906575
181Pruritus (HP:0000989)1.69363107
182Abnormality of B cell number (HP:0010975)1.69194297
183Slow saccadic eye movements (HP:0000514)1.68729502
184Esophageal atresia (HP:0002032)1.67278048
185Aplasia/Hypoplasia of the spleen (HP:0010451)1.67015056
186Abnormally folded helix (HP:0008544)1.66601422
187Delayed CNS myelination (HP:0002188)1.64902721
188Congenital sensorineural hearing impairment (HP:0008527)1.64668654
189* Abnormal sex determination (HP:0012244)1.64380056
190* Sex reversal (HP:0012245)1.64380056
191Hepatosplenomegaly (HP:0001433)1.63621525
192Premature skin wrinkling (HP:0100678)1.63503614
193Microcytic anemia (HP:0001935)1.60024344
194Abnormality of the parathyroid morphology (HP:0011766)1.59434926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK9.77889501
2RIPK43.73345912
3MKNK23.64385530
4MAP4K13.11232490
5EIF2AK32.94007009
6TNIK2.93754404
7PHKG12.85372076
8PHKG22.85372076
9TYK22.60217458
10STK392.45281347
11GRK62.39160849
12MAP2K32.33083368
13TXK2.27751657
14CLK12.26327854
15MKNK12.19193046
16FES2.13488836
17BMPR22.02688723
18PKN11.99245253
19JAK31.96078586
20JAK11.83082347
21STK161.76687294
22ZAP701.75368367
23FGFR31.70511194
24BLK1.61059994
25TLK11.60412111
26EPHB11.53275763
27OXSR11.51174786
28MAP3K21.48968326
29EIF2AK21.47997031
30GRK11.47540739
31MAP3K31.47126990
32MAPK151.46260579
33SIK31.45371095
34PIK3CG1.44391445
35IRAK41.42808352
36MARK31.41735924
37UHMK11.40496228
38MAP3K101.37526488
39JAK21.33430938
40SGK21.26269627
41TNK21.19544723
42GRK71.16399641
43PBK1.15511960
44IKBKB1.09335637
45BMPR1B1.09333631
46SGK31.08010178
47CDK61.02078318
48STK101.00263266
49FGR0.99542017
50INSRR0.99250759
51CSNK1G10.97210194
52FRK0.95469285
53BRD40.94428712
54YES10.93742246
55NLK0.92433070
56MAPKAPK50.91089619
57IRAK20.89054160
58FGFR40.87915639
59TBK10.87529991
60PIM10.86278504
61MST40.85696706
62MATK0.84203316
63TGFBR20.83188702
64PAK20.81516577
65ADRBK20.80675192
66MELK0.79549173
67CSNK1G30.79431659
68MAPK70.78637080
69MUSK0.78174766
70CDK120.77096609
71KIT0.76614657
72TAOK10.75896400
73CAMK2B0.75779411
74VRK10.75667137
75ERBB40.75586238
76CSNK1A1L0.74145445
77DYRK20.73600746
78PNCK0.70675471
79PDK10.70533107
80CDK40.70427920
81IRAK10.70312151
82ROCK20.70214473
83TEC0.68821712
84TRPM70.67154741
85MAP3K60.66676862
86LRRK20.66553769
87TAOK30.65530906
88BCR0.64711814
89PRPF4B0.63242484
90WNK40.62145292
91CHUK0.61876306
92NEK60.60282478
93AKT30.60163518
94GSK3A0.59349686
95CDK190.58770703
96STK240.58680795
97MAPK130.58388159
98MAP2K20.58385194
99PRKAA20.58309047
100RET0.56908403
101STK40.55350014
102NEK90.55128671
103SGK2230.55102270
104SGK4940.55102270
105PRKG10.54297706
106CSK0.54140577
107DYRK1A0.53686334
108MAP3K140.53187028
109KSR20.51374330
110CDK30.50297351
111RAF10.50212983
112RPS6KA50.49754766
113FGFR20.49332940
114EGFR0.47386606
115CAMK2A0.47337156
116PDGFRB0.47047001
117* MAP3K10.46986066
118CSNK1G20.46911010
119LCK0.45020309
120ACVR1B0.44609857
121SRPK10.44587248
122MAP3K70.44439636
123MAP3K50.43687664
124CAMK2D0.42555794
125PRKCQ0.41013659
126PRKCE0.40872179
127ERBB20.40741317
128IRAK30.40545160
129DYRK1B0.40216404
130CAMKK10.39989214
131PTK2B0.39789189
132FER0.39279910
133CAMK2G0.38245944
134CAMK40.38112252
135HIPK20.37979572
136CSNK1D0.37117344
137WNK10.37089072
138LYN0.37050203
139MAPK40.37021974
140STK110.36101147
141PTK60.35863561
142MET0.35842190
143PRKD10.34907579
144ERN10.34412464
145MAPK120.34360443
146CAMKK20.33954916
147SGK10.32218743
148PDPK10.31112143
149ABL10.30845711
150IKBKE0.30566573
151MARK20.29812262
152NTRK20.27809391
153MST1R0.27291805
154ITK0.26988472
155MAPK110.26607860
156MAP3K130.26384430
157BTK0.26192580
158MAPK100.26178675
159SYK0.26143259
160* PAK10.25150590
161PRKACA0.24475324
162CSF1R0.23314192
163PRKCD0.23174951
164HCK0.21901141
165FYN0.21397879

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.49445511
2Protein export_Homo sapiens_hsa030602.99893743
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.83820150
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.79582523
5Leishmaniasis_Homo sapiens_hsa051402.72466637
6Steroid biosynthesis_Homo sapiens_hsa001002.68060724
7Phototransduction_Homo sapiens_hsa047442.59314180
8Ether lipid metabolism_Homo sapiens_hsa005652.54848068
9B cell receptor signaling pathway_Homo sapiens_hsa046622.53674425
10Ribosome_Homo sapiens_hsa030102.50983952
11Osteoclast differentiation_Homo sapiens_hsa043802.46997124
12Histidine metabolism_Homo sapiens_hsa003402.33607675
13Sphingolipid metabolism_Homo sapiens_hsa006002.20092928
14T cell receptor signaling pathway_Homo sapiens_hsa046602.14727047
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.12364213
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03121361
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92234911
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89363709
19Oxidative phosphorylation_Homo sapiens_hsa001901.88916275
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86028853
21Tuberculosis_Homo sapiens_hsa051521.81921041
22Measles_Homo sapiens_hsa051621.80772909
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.80536794
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80368835
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76942119
26Acute myeloid leukemia_Homo sapiens_hsa052211.70258043
27Non-small cell lung cancer_Homo sapiens_hsa052231.69999205
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69913125
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69263857
30Axon guidance_Homo sapiens_hsa043601.69199244
31ABC transporters_Homo sapiens_hsa020101.65777077
32Type I diabetes mellitus_Homo sapiens_hsa049401.62611296
33Toxoplasmosis_Homo sapiens_hsa051451.59754203
34Long-term depression_Homo sapiens_hsa047301.56308563
35Other glycan degradation_Homo sapiens_hsa005111.54693714
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.54267789
37Influenza A_Homo sapiens_hsa051641.49304424
38Antigen processing and presentation_Homo sapiens_hsa046121.46515757
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45275693
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39059915
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.38744972
42Herpes simplex infection_Homo sapiens_hsa051681.38226308
43Chemokine signaling pathway_Homo sapiens_hsa040621.36900516
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33701499
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33426005
46Viral myocarditis_Homo sapiens_hsa054161.32691751
47Platelet activation_Homo sapiens_hsa046111.31597961
48Retinol metabolism_Homo sapiens_hsa008301.29008442
49Legionellosis_Homo sapiens_hsa051341.28786956
50Arachidonic acid metabolism_Homo sapiens_hsa005901.27939988
51* Hepatitis B_Homo sapiens_hsa051611.27684468
52Complement and coagulation cascades_Homo sapiens_hsa046101.26417250
53TNF signaling pathway_Homo sapiens_hsa046681.24588632
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.23261872
55* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23109685
56Pancreatic cancer_Homo sapiens_hsa052121.22979952
57Fanconi anemia pathway_Homo sapiens_hsa034601.22760354
58Vitamin digestion and absorption_Homo sapiens_hsa049771.21051113
59Autoimmune thyroid disease_Homo sapiens_hsa053201.20293964
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17617299
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16904359
62Chronic myeloid leukemia_Homo sapiens_hsa052201.16172227
63Linoleic acid metabolism_Homo sapiens_hsa005911.15713528
64Renal cell carcinoma_Homo sapiens_hsa052111.14656102
65Alzheimers disease_Homo sapiens_hsa050101.12368271
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12138824
67Sulfur metabolism_Homo sapiens_hsa009201.10687094
68Endometrial cancer_Homo sapiens_hsa052131.09623923
69Prolactin signaling pathway_Homo sapiens_hsa049171.09237377
70FoxO signaling pathway_Homo sapiens_hsa040681.05749944
71Butanoate metabolism_Homo sapiens_hsa006501.04890771
72Hepatitis C_Homo sapiens_hsa051601.03441866
73beta-Alanine metabolism_Homo sapiens_hsa004101.01539314
74Inositol phosphate metabolism_Homo sapiens_hsa005621.01392025
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00405760
76Parkinsons disease_Homo sapiens_hsa050121.00170586
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95947446
78Peroxisome_Homo sapiens_hsa041460.95669992
79Colorectal cancer_Homo sapiens_hsa052100.95335272
80Serotonergic synapse_Homo sapiens_hsa047260.94811582
81Apoptosis_Homo sapiens_hsa042100.94497699
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93410505
83Nicotine addiction_Homo sapiens_hsa050330.91426189
84VEGF signaling pathway_Homo sapiens_hsa043700.90112800
85Staphylococcus aureus infection_Homo sapiens_hsa051500.89694009
86Prostate cancer_Homo sapiens_hsa052150.87703636
87Choline metabolism in cancer_Homo sapiens_hsa052310.86914101
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86890899
89* Neurotrophin signaling pathway_Homo sapiens_hsa047220.85798831
90mTOR signaling pathway_Homo sapiens_hsa041500.85687516
91Thyroid cancer_Homo sapiens_hsa052160.85220525
92Asthma_Homo sapiens_hsa053100.84915452
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83615347
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.82350409
95Calcium signaling pathway_Homo sapiens_hsa040200.80595561
96Glutamatergic synapse_Homo sapiens_hsa047240.78318309
97Viral carcinogenesis_Homo sapiens_hsa052030.77811356
98Tyrosine metabolism_Homo sapiens_hsa003500.77035659
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76722905
100Tryptophan metabolism_Homo sapiens_hsa003800.75432502
101Malaria_Homo sapiens_hsa051440.75210600
102Glutathione metabolism_Homo sapiens_hsa004800.75163012
103Arginine and proline metabolism_Homo sapiens_hsa003300.74558754
104Pertussis_Homo sapiens_hsa051330.72782515
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72483983
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72340571
107Rheumatoid arthritis_Homo sapiens_hsa053230.68710614
108Epstein-Barr virus infection_Homo sapiens_hsa051690.68074328
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.67752340
110* HTLV-I infection_Homo sapiens_hsa051660.67674197
111Vitamin B6 metabolism_Homo sapiens_hsa007500.67147831
112ErbB signaling pathway_Homo sapiens_hsa040120.66209952
113Glioma_Homo sapiens_hsa052140.64180946
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64152394
115Chemical carcinogenesis_Homo sapiens_hsa052040.62844226
116Primary immunodeficiency_Homo sapiens_hsa053400.61873737
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61249862
118HIF-1 signaling pathway_Homo sapiens_hsa040660.61149021
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60659125
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59754100
121Insulin resistance_Homo sapiens_hsa049310.59426859
122Circadian rhythm_Homo sapiens_hsa047100.58314464
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57389841
124Shigellosis_Homo sapiens_hsa051310.56875586
125Taste transduction_Homo sapiens_hsa047420.55904616
126Notch signaling pathway_Homo sapiens_hsa043300.55396791
127Cocaine addiction_Homo sapiens_hsa050300.54389583
128Ovarian steroidogenesis_Homo sapiens_hsa049130.54104481
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53503804
130MicroRNAs in cancer_Homo sapiens_hsa052060.52018181
131Melanogenesis_Homo sapiens_hsa049160.51265014
132* GnRH signaling pathway_Homo sapiens_hsa049120.51262407
133Regulation of autophagy_Homo sapiens_hsa041400.51063774
134Amoebiasis_Homo sapiens_hsa051460.50115740
135Small cell lung cancer_Homo sapiens_hsa052220.50048528
136Graft-versus-host disease_Homo sapiens_hsa053320.49978643
137Morphine addiction_Homo sapiens_hsa050320.49851872
138Allograft rejection_Homo sapiens_hsa053300.49388920
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49068398
140Endocytosis_Homo sapiens_hsa041440.49064070
141Folate biosynthesis_Homo sapiens_hsa007900.48139494
142* MAPK signaling pathway_Homo sapiens_hsa040100.47684096
143Cardiac muscle contraction_Homo sapiens_hsa042600.47377687
144Metabolic pathways_Homo sapiens_hsa011000.46993693
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46689760
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46058113
147Basal cell carcinoma_Homo sapiens_hsa052170.45753529
148Huntingtons disease_Homo sapiens_hsa050160.45688180
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45650669
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.45234981
151Systemic lupus erythematosus_Homo sapiens_hsa053220.44481057
152Salmonella infection_Homo sapiens_hsa051320.43520174
153Long-term potentiation_Homo sapiens_hsa047200.43171189
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42997646
155Nitrogen metabolism_Homo sapiens_hsa009100.42938226
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.42631482
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.42336445
158Estrogen signaling pathway_Homo sapiens_hsa049150.41598152
159Ras signaling pathway_Homo sapiens_hsa040140.38891744
160Glycosaminoglycan degradation_Homo sapiens_hsa005310.38150425
161Dorso-ventral axis formation_Homo sapiens_hsa043200.38027293
162Fatty acid metabolism_Homo sapiens_hsa012120.37364119
163Hedgehog signaling pathway_Homo sapiens_hsa043400.36479717
164Wnt signaling pathway_Homo sapiens_hsa043100.35520816
165NF-kappa B signaling pathway_Homo sapiens_hsa040640.34223308
166Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33968342
167GABAergic synapse_Homo sapiens_hsa047270.30054613
168Homologous recombination_Homo sapiens_hsa034400.29804901
169Phagosome_Homo sapiens_hsa041450.29729518
170Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29548162
171Leukocyte transendothelial migration_Homo sapiens_hsa046700.29139458
172Hematopoietic cell lineage_Homo sapiens_hsa046400.27640104
173Sphingolipid signaling pathway_Homo sapiens_hsa040710.27328344
174Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26916490
175Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26777375
176Renin secretion_Homo sapiens_hsa049240.25837840
177African trypanosomiasis_Homo sapiens_hsa051430.24911577

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