MAP3K11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77131131
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77131131
3negative regulation of cell killing (GO:0031342)4.51298265
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.51298265
5response to peptidoglycan (GO:0032494)4.29247212
6antigen processing and presentation of endogenous antigen (GO:0019883)4.21861791
7detection of other organism (GO:0098543)4.01066276
8macrophage activation involved in immune response (GO:0002281)3.99040092
9detection of bacterium (GO:0016045)3.96915873
10regulation of gamma-delta T cell differentiation (GO:0045586)3.94870559
11positive regulation of gamma-delta T cell activation (GO:0046645)3.83511629
12neutrophil activation involved in immune response (GO:0002283)3.78832051
13regulation of gamma-delta T cell activation (GO:0046643)3.56069707
14negative regulation of erythrocyte differentiation (GO:0045647)3.43353843
15detection of external biotic stimulus (GO:0098581)3.41677661
16positive regulation of Cdc42 GTPase activity (GO:0043089)3.25318183
17leukocyte aggregation (GO:0070486)3.24262544
18germinal center formation (GO:0002467)3.17905194
19regulation of mast cell degranulation (GO:0043304)3.16913781
20low-density lipoprotein particle clearance (GO:0034383)3.13754320
21response to host immune response (GO:0052572)3.12903085
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12903085
23positive regulation of histone deacetylation (GO:0031065)3.10310929
24regulation of leukocyte degranulation (GO:0043300)3.09118991
25regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08933266
26regulation of cholesterol storage (GO:0010885)3.07445575
27detection of molecule of bacterial origin (GO:0032490)3.05419693
28lipopolysaccharide-mediated signaling pathway (GO:0031663)3.05204933
29regulation of cholesterol homeostasis (GO:2000188)3.04786567
30response to laminar fluid shear stress (GO:0034616)3.04042128
31response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00495931
32response to host (GO:0075136)3.00495931
33response to host defenses (GO:0052200)3.00495931
34detection of biotic stimulus (GO:0009595)2.99528142
35positive thymic T cell selection (GO:0045059)2.98776700
36response to type I interferon (GO:0034340)2.95112784
37regulation of interleukin-12 biosynthetic process (GO:0045075)2.94010885
38type I interferon signaling pathway (GO:0060337)2.93277496
39cellular response to type I interferon (GO:0071357)2.93277496
40regulation of B cell receptor signaling pathway (GO:0050855)2.92994742
41morphogenesis of an endothelium (GO:0003159)2.92423331
42endothelial tube morphogenesis (GO:0061154)2.92423331
43positive regulation of B cell differentiation (GO:0045579)2.91762814
44JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.90103956
45regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90069075
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88560577
47respiratory burst (GO:0045730)2.83929167
48neutrophil activation (GO:0042119)2.82407037
49growth hormone receptor signaling pathway (GO:0060396)2.80492540
50macrophage activation (GO:0042116)2.80299725
51valine metabolic process (GO:0006573)2.79359307
52regulation of mast cell activation involved in immune response (GO:0033006)2.78316413
53pentose-phosphate shunt (GO:0006098)2.78313707
54granulocyte activation (GO:0036230)2.78193830
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77806549
56regulation of interferon-beta biosynthetic process (GO:0045357)2.77399640
57positive regulation by symbiont of host defense response (GO:0052509)2.74842378
58modulation by symbiont of host defense response (GO:0052031)2.74842378
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74842378
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74842378
61positive regulation by organism of defense response of other organism involved in symbiotic interact2.74842378
62modulation by symbiont of host immune response (GO:0052553)2.74842378
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73558775
64negative regulation of innate immune response (GO:0045824)2.73330034
65negative regulation of leukocyte mediated immunity (GO:0002704)2.72472298
66negative regulation of lymphocyte mediated immunity (GO:0002707)2.71413186
67regulation of T-helper 2 cell differentiation (GO:0045628)2.70418579
68myeloid cell activation involved in immune response (GO:0002275)2.69539630
69negative regulation of cytokine production involved in immune response (GO:0002719)2.68498854
70regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.67616723
71modulation by symbiont of host cellular process (GO:0044068)2.67595973
72defense response to protozoan (GO:0042832)2.67193983
73alpha-linolenic acid metabolic process (GO:0036109)2.66927875
74regulation of antigen processing and presentation (GO:0002577)2.63308541
75positive regulation of antigen processing and presentation (GO:0002579)2.60783107
76negative regulation of cholesterol transport (GO:0032375)2.60518510
77negative regulation of sterol transport (GO:0032372)2.60518510
78apoptotic cell clearance (GO:0043277)2.59854346
79interferon-gamma-mediated signaling pathway (GO:0060333)2.59249328
80peptidyl-glutamic acid carboxylation (GO:0017187)2.58801446
81protein carboxylation (GO:0018214)2.58801446
82plasma lipoprotein particle clearance (GO:0034381)2.58236736
83negative regulation of granulocyte differentiation (GO:0030853)2.58140808
84triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.55805793
85response to protozoan (GO:0001562)2.54307359
86modulation by virus of host process (GO:0019054)2.53308876
87antigen processing and presentation via MHC class Ib (GO:0002475)2.52947271
88complement activation, alternative pathway (GO:0006957)2.50532143
89endothelial cell chemotaxis (GO:0035767)2.50275966
90regulation of regulated secretory pathway (GO:1903305)2.50115547
91positive regulation of triglyceride metabolic process (GO:0090208)2.49956290
92regulation of T cell tolerance induction (GO:0002664)2.49903645
93positive regulation of triglyceride biosynthetic process (GO:0010867)2.49197997
94protein-lipid complex assembly (GO:0065005)2.48633458
95T cell selection (GO:0045058)2.48160875
96lysine catabolic process (GO:0006554)2.47946886
97lysine metabolic process (GO:0006553)2.47946886
98myeloid dendritic cell differentiation (GO:0043011)2.47811431
99B cell receptor signaling pathway (GO:0050853)2.47336341
100negative regulation of interleukin-6 production (GO:0032715)2.45595187
101positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.45252003
102L-phenylalanine metabolic process (GO:0006558)2.45050351
103erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.45050351
104maternal placenta development (GO:0001893)2.44054946
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43842846
106positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43389384
107positive regulation of cellular amide metabolic process (GO:0034250)2.43019875
108NADPH regeneration (GO:0006740)2.42448697
109mannose metabolic process (GO:0006013)2.42269495
110regulation of fatty acid beta-oxidation (GO:0031998)2.42252799
111positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.41423719
112negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41419015
113regulation of triglyceride catabolic process (GO:0010896)2.40942096
114regulation of necrotic cell death (GO:0010939)2.40737114
115protein localization to endosome (GO:0036010)2.40732095
116cellular response to growth hormone stimulus (GO:0071378)2.39958985
117positive regulation of protein deacetylation (GO:0090312)2.39074945
118response to muramyl dipeptide (GO:0032495)2.38835766
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.37678844
120positive regulation of lipoprotein lipase activity (GO:0051006)2.37468048
121positive regulation of triglyceride lipase activity (GO:0061365)2.37468048
122negative regulation of interleukin-12 production (GO:0032695)2.36440812
123cellular extravasation (GO:0045123)2.35894712
124negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.35033885
125regulation of necroptotic process (GO:0060544)2.35022292
126Arp2/3 complex-mediated actin nucleation (GO:0034314)2.34780427
127urea cycle (GO:0000050)2.34655794
128urea metabolic process (GO:0019627)2.34655794
129phospholipid efflux (GO:0033700)2.34492587
130leukocyte migration involved in inflammatory response (GO:0002523)2.34197838
131B cell mediated immunity (GO:0019724)2.33968870
132microglial cell activation (GO:0001774)2.33910244
133NIK/NF-kappaB signaling (GO:0038061)2.33313033
134immunoglobulin mediated immune response (GO:0016064)2.33034544
135T-helper 1 type immune response (GO:0042088)2.32546777
136positive regulation of lipid storage (GO:0010884)2.32352392
137epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31937097
138plasma lipoprotein particle assembly (GO:0034377)2.31867387
139myeloid dendritic cell activation (GO:0001773)2.31709616
1402-oxoglutarate metabolic process (GO:0006103)2.31702366
141natural killer cell differentiation (GO:0001779)2.30647756
142positive regulation of p38MAPK cascade (GO:1900745)2.30546466
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.30331523
144thymic T cell selection (GO:0045061)2.29560530
145angiogenesis involved in wound healing (GO:0060055)2.29368448
146positive regulation of interferon-alpha production (GO:0032727)2.28900626
147tricarboxylic acid metabolic process (GO:0072350)2.28005833
148cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.27577710
149pinocytosis (GO:0006907)2.27397885
150cysteine metabolic process (GO:0006534)2.26637806
151L-phenylalanine catabolic process (GO:0006559)2.25573723
152erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.25573723
153regulation of B cell differentiation (GO:0045577)2.24980464
154regulation of superoxide anion generation (GO:0032928)2.24439759
155negative regulation of fibrinolysis (GO:0051918)2.22630734
156positive regulation of lamellipodium assembly (GO:0010592)2.21154662
157apoptotic process involved in morphogenesis (GO:0060561)2.18438297
158sulfur amino acid catabolic process (GO:0000098)2.17029651
159phospholipid homeostasis (GO:0055091)2.16857657
160defense response to fungus (GO:0050832)2.15687879
161tolerance induction (GO:0002507)2.15298924
162regulation of interferon-alpha production (GO:0032647)2.14493208
163glyoxylate metabolic process (GO:0046487)2.14280510
164vascular endothelial growth factor signaling pathway (GO:0038084)2.11907932
165ethanol oxidation (GO:0006069)2.11745348
166negative regulation of phagocytosis (GO:0050765)2.11487844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.59460241
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94061589
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83756071
4MYC_22102868_ChIP-Seq_BL_Human2.83579915
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.66563874
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.63430842
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.61435933
8VDR_21846776_ChIP-Seq_THP-1_Human2.60476686
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.34705204
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.24494957
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20059356
12TCF7_22412390_ChIP-Seq_EML_Mouse2.13843000
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.13403046
14SCL_19346495_ChIP-Seq_HPC-7_Human2.11440998
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07257503
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.07243625
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06854333
18* MAF_26560356_Chip-Seq_TH1_Human2.01929387
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01380310
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87370831
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84802402
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84719987
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84022817
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83119392
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82799833
26KDM2B_26808549_Chip-Seq_DND41_Human1.79970485
27UTX_26944678_Chip-Seq_JUKART_Human1.76058231
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.75862772
29VDR_24763502_ChIP-Seq_THP-1_Human1.75699370
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73443005
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73261480
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70600884
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.66571183
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65987035
35CLOCK_20551151_ChIP-Seq_293T_Human1.65502170
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65169355
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64746965
38* LXR_22292898_ChIP-Seq_THP-1_Human1.64611796
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63427297
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62473257
41* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61790389
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52923032
43* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50701238
44RACK7_27058665_Chip-Seq_MCF-7_Human1.49799336
45KDM2B_26808549_Chip-Seq_K562_Human1.49796418
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.48568035
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.48457886
48MYB_26560356_Chip-Seq_TH1_Human1.46711503
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46455511
50MYB_26560356_Chip-Seq_TH2_Human1.44893009
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43047167
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42954895
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40214484
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39871287
55ZNF263_19887448_ChIP-Seq_K562_Human1.39546396
56RUNX_20019798_ChIP-Seq_JUKART_Human1.39312140
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39286472
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39119188
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.38516098
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36754386
61E2F7_22180533_ChIP-Seq_HELA_Human1.36166008
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.33350973
63* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33291716
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32945699
65* MAF_26560356_Chip-Seq_TH2_Human1.32943034
66SPI1_23127762_ChIP-Seq_K562_Human1.32710926
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32654102
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32211105
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31145631
70* TET1_21451524_ChIP-Seq_MESCs_Mouse1.30403118
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30353589
72GATA1_22025678_ChIP-Seq_K562_Human1.29909588
73SMC4_20622854_ChIP-Seq_HELA_Human1.29833516
74* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28862644
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28564474
76GATA1_19941826_ChIP-Seq_K562_Human1.26869104
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25187005
78SPI1_23547873_ChIP-Seq_NB4_Human1.24529444
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23821486
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22359361
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21556600
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19754216
83ATF3_27146783_Chip-Seq_COLON_Human1.19452641
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.19359443
85* NCOR1_26117541_ChIP-Seq_K562_Human1.19291379
86* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18896804
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18278246
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17478932
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17355750
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16818957
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16670079
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15734665
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15644929
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14586193
95* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13044246
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11710655
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10291294
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10274245
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09859983
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08566584
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07964292
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07686316
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06752025
104CREB1_26743006_Chip-Seq_LNCaP_Human1.05950818
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.05523340
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05505821
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05132885
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.04986618
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04601462
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04117254
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03601201
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.03544382
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02547824
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02469381
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01634157
116* BCOR_27268052_Chip-Seq_Bcells_Human1.01438689
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00785805
118GATA6_25053715_ChIP-Seq_YYC3_Human1.00596862
119* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99000931
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98997367
121* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98386118
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.98258912
123GATA2_19941826_ChIP-Seq_K562_Human0.97394490
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.97307362
125* P68_20966046_ChIP-Seq_HELA_Human0.97237910
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96907880
127BCL6_27268052_Chip-Seq_Bcells_Human0.94981191
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.93682124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.01075441
2MP0005360_urolithiasis2.82723731
3MP0003300_gastrointestinal_ulcer2.71986516
4MP0003705_abnormal_hypodermis_morpholog2.67869846
5MP0003172_abnormal_lysosome_physiology2.50419275
6MP0003303_peritoneal_inflammation2.44676853
7MP0003191_abnormal_cellular_cholesterol2.44545110
8MP0002139_abnormal_hepatobiliary_system2.31812922
9MP0010368_abnormal_lymphatic_system2.28012691
10MP0000685_abnormal_immune_system2.17413507
11MP0003436_decreased_susceptibility_to2.14101806
12MP0008260_abnormal_autophagy2.08628905
13MP0009278_abnormal_bone_marrow1.95841787
14MP0001835_abnormal_antigen_presentation1.84680967
15MP0005365_abnormal_bile_salt1.80851794
16MP0002138_abnormal_hepatobiliary_system1.79389353
17MP0005387_immune_system_phenotype1.74788302
18MP0001790_abnormal_immune_system1.74788302
19MP0005464_abnormal_platelet_physiology1.67533297
20MP0010352_gastrointestinal_tract_polyps1.67106608
21MP0001800_abnormal_humoral_immune1.64940039
22MP0004947_skin_inflammation1.64099346
23MP0005058_abnormal_lysosome_morphology1.60773862
24MP0005085_abnormal_gallbladder_physiolo1.59746682
25MP0005025_abnormal_response_to1.57768264
26MP0005083_abnormal_biliary_tract1.56727907
27MP0004381_abnormal_hair_follicle1.56275489
28MP0003566_abnormal_cell_adhesion1.54320538
29MP0003183_abnormal_peptide_metabolism1.53350676
30MP0004510_myositis1.53040189
31MP0010155_abnormal_intestine_physiology1.51025519
32MP0002452_abnormal_antigen_presenting1.48941921
33MP0002419_abnormal_innate_immunity1.47458418
34MP0002166_altered_tumor_susceptibility1.46355019
35MP0000858_altered_metastatic_potential1.45465008
36MP0003075_altered_response_to1.44926524
37MP0005397_hematopoietic_system_phenotyp1.44414091
38MP0001545_abnormal_hematopoietic_system1.44414091
39MP0009785_altered_susceptibility_to1.43711735
40MP0005000_abnormal_immune_tolerance1.43210964
41MP0000465_gastrointestinal_hemorrhage1.43145116
42MP0003724_increased_susceptibility_to1.43127249
43MP0002998_abnormal_bone_remodeling1.41757735
44MP0002723_abnormal_immune_serum1.40598565
45MP0010329_abnormal_lipoprotein_level1.40426609
46MP0002396_abnormal_hematopoietic_system1.40020350
47MP0000609_abnormal_liver_physiology1.39524521
48MP0005310_abnormal_salivary_gland1.38781538
49MP0003252_abnormal_bile_duct1.38463002
50MP0001873_stomach_inflammation1.37582389
51MP0001879_abnormal_lymphatic_vessel1.36629329
52MP0002405_respiratory_system_inflammati1.36181486
53MP0003763_abnormal_thymus_physiology1.35541038
54MP0002420_abnormal_adaptive_immunity1.34460579
55MP0001819_abnormal_immune_cell1.33462586
56MP0008875_abnormal_xenobiotic_pharmacok1.33081719
57MP0005167_abnormal_blood-brain_barrier1.30685016
58MP0004858_abnormal_nervous_system1.30304600
59MP0009333_abnormal_splenocyte_physiolog1.27869701
60MP0006082_CNS_inflammation1.27526702
61MP0002398_abnormal_bone_marrow1.27494294
62MP0004808_abnormal_hematopoietic_stem1.23896842
63MP0001845_abnormal_inflammatory_respons1.22447693
64MP0001666_abnormal_nutrient_absorption1.21771571
65MP0000689_abnormal_spleen_morphology1.21204014
66MP0000716_abnormal_immune_system1.19445309
67MP0005671_abnormal_response_to1.18458597
68MP0002722_abnormal_immune_system1.16685805
69MP0008469_abnormal_protein_level1.14391408
70MP0009764_decreased_sensitivity_to1.13314489
71MP0003866_abnormal_defecation1.13182529
72MP0005023_abnormal_wound_healing1.11649478
73MP0002429_abnormal_blood_cell1.10430529
74MP0000604_amyloidosis1.09476009
75MP0004185_abnormal_adipocyte_glucose1.09294406
76MP0009643_abnormal_urine_homeostasis1.09192207
77MP0002254_reproductive_system_inflammat1.07027543
78MP0001533_abnormal_skeleton_physiology1.06104907
79MP0001853_heart_inflammation1.05177504
80MP0005076_abnormal_cell_differentiation1.04116791
81MP0003453_abnormal_keratinocyte_physiol1.03624787
82MP0005166_decreased_susceptibility_to1.03201750
83MP0005409_darkened_coat_color1.03114506
84MP0006054_spinal_hemorrhage1.02825751
85MP0003091_abnormal_cell_migration1.02762363
86MP0000598_abnormal_liver_morphology1.02481578
87MP0001663_abnormal_digestive_system1.00675346
88MP0002132_abnormal_respiratory_system0.98499435
89MP0005451_abnormal_body_composition0.97903008
90MP0002148_abnormal_hypersensitivity_rea0.97346809
91MP0003828_pulmonary_edema0.96850295
92MP0005319_abnormal_enzyme/_coenzyme0.95981156
93MP0008961_abnormal_basal_metabolism0.92398428
94MP0002933_joint_inflammation0.91108477
95MP0002877_abnormal_melanocyte_morpholog0.90488275
96MP0005390_skeleton_phenotype0.90386050
97MP0001851_eye_inflammation0.90009067
98MP0003656_abnormal_erythrocyte_physiolo0.89965496
99MP0000249_abnormal_blood_vessel0.88366181
100MP0010234_abnormal_vibrissa_follicle0.87751211
101MP0005666_abnormal_adipose_tissue0.87710299
102MP0002136_abnormal_kidney_physiology0.87462074
103MP0002006_tumorigenesis0.87355808
104MP0003690_abnormal_glial_cell0.85960868
105MP0003806_abnormal_nucleotide_metabolis0.85664083
106MP0000703_abnormal_thymus_morphology0.85214866
107MP0000490_abnormal_crypts_of0.85078896
108MP0001849_ear_inflammation0.84412328
109MP0000767_abnormal_smooth_muscle0.84359247
110MP0005670_abnormal_white_adipose0.84143283
111MP0000343_altered_response_to0.84025637
112MP0001915_intracranial_hemorrhage0.84013125
113MP0002118_abnormal_lipid_homeostasis0.83051527
114MP0009763_increased_sensitivity_to0.82492025
115MP0004264_abnormal_extraembryonic_tissu0.82371285
116MP0010630_abnormal_cardiac_muscle0.82159120
117MP0004272_abnormal_basement_membrane0.80947668
118MP0003279_aneurysm0.80671064
119MP0003329_amyloid_beta_deposits0.80303874
120MP0010307_abnormal_tumor_latency0.80060993
121MP0003448_altered_tumor_morphology0.79850720
122MP0005332_abnormal_amino_acid0.78625617
123MP0004883_abnormal_blood_vessel0.77778281
124MP0005164_abnormal_response_to0.77007148
125MP0000678_abnormal_parathyroid_gland0.73297013
126MP0005375_adipose_tissue_phenotype0.71006022
127MP0005075_abnormal_melanosome_morpholog0.70394315
128MP0000015_abnormal_ear_pigmentation0.69135172

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)3.65476986
2Orchitis (HP:0100796)3.62379995
3Deep venous thrombosis (HP:0002625)3.57181560
4Eczematoid dermatitis (HP:0000976)3.43396269
5Polycythemia (HP:0001901)3.40821972
6Systemic lupus erythematosus (HP:0002725)3.36649931
7Abnormality of liposaccharide metabolism (HP:0010968)3.30667276
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.30667276
9Abnormality of glycolipid metabolism (HP:0010969)3.30667276
10Chronic obstructive pulmonary disease (HP:0006510)3.22286555
11Obstructive lung disease (HP:0006536)3.22286555
12Abnormality of the nasal mucosa (HP:0000433)3.18814448
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.17537877
14Hematochezia (HP:0002573)3.15688826
15Mediastinal lymphadenopathy (HP:0100721)3.09934864
16Retrobulbar optic neuritis (HP:0100654)3.06963863
17Optic neuritis (HP:0100653)3.06963863
18Esophageal varix (HP:0002040)3.03791961
19Autoimmune thrombocytopenia (HP:0001973)2.91581563
20Xanthomatosis (HP:0000991)2.89685433
21Gingivitis (HP:0000230)2.89459171
22Complement deficiency (HP:0004431)2.88180226
23Meningitis (HP:0001287)2.80006450
24Pustule (HP:0200039)2.79973844
25Elevated erythrocyte sedimentation rate (HP:0003565)2.78572219
26Cerebral aneurysm (HP:0004944)2.73418736
27Myocardial infarction (HP:0001658)2.72375082
28Gastrointestinal infarctions (HP:0005244)2.69462204
29Recurrent gram-negative bacterial infections (HP:0005420)2.66110225
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65437789
31Stomatitis (HP:0010280)2.62388581
32Purpura (HP:0000979)2.58605597
33Nasal polyposis (HP:0100582)2.57071633
34Abnormality of complement system (HP:0005339)2.56333920
35Cellulitis (HP:0100658)2.56163121
36Interstitial pulmonary disease (HP:0006530)2.54318043
37Amyloidosis (HP:0011034)2.53146535
38Recurrent fungal infections (HP:0002841)2.47163553
39Vasculitis (HP:0002633)2.46882807
40Chronic otitis media (HP:0000389)2.46500863
41Recurrent abscess formation (HP:0002722)2.45609068
42Gastrointestinal inflammation (HP:0004386)2.43386124
43Abnormal platelet function (HP:0011869)2.43316901
44Impaired platelet aggregation (HP:0003540)2.43316901
45Colitis (HP:0002583)2.43069713
46Glomerulonephritis (HP:0000099)2.41654767
47Recurrent viral infections (HP:0004429)2.41317466
48Inflammation of the large intestine (HP:0002037)2.38014526
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37627276
50Vacuolated lymphocytes (HP:0001922)2.34026098
51Recurrent bacterial skin infections (HP:0005406)2.33356465
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28752189
53Malnutrition (HP:0004395)2.28685965
54Segmental peripheral demyelination/remyelination (HP:0003481)2.24459521
55Abnormality of macrophages (HP:0004311)2.23428523
56Polygenic inheritance (HP:0010982)2.21204123
57Axonal loss (HP:0003447)2.20421113
58Hemoptysis (HP:0002105)2.20129518
59Epistaxis (HP:0000421)2.19394908
60IgM deficiency (HP:0002850)2.18770184
61Encephalitis (HP:0002383)2.17987352
62Keratoconjunctivitis sicca (HP:0001097)2.17431496
63Intrahepatic cholestasis (HP:0001406)2.17317215
64Increased IgE level (HP:0003212)2.16530569
65Chronic mucocutaneous candidiasis (HP:0002728)2.14865164
66Recurrent cutaneous fungal infections (HP:0011370)2.14865164
67Asymmetric septal hypertrophy (HP:0001670)2.14118012
68Fatigue (HP:0012378)2.13849289
69Joint hemorrhage (HP:0005261)2.13787177
70Pulmonary infiltrates (HP:0002113)2.12833520
71Dysostosis multiplex (HP:0000943)2.12570552
72Chest pain (HP:0100749)2.11457210
73Abnormality of the common coagulation pathway (HP:0010990)2.11005358
74Hypochromic anemia (HP:0001931)2.10359295
75Broad face (HP:0000283)2.09554879
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.07552824
77Peritonitis (HP:0002586)2.06962683
78Hypertriglyceridemia (HP:0002155)2.06299814
79Gingival bleeding (HP:0000225)2.05981631
80Increased serum ferritin (HP:0003281)2.04275059
81J-shaped sella turcica (HP:0002680)2.03810188
82Hemorrhage of the eye (HP:0011885)2.02088560
83Verrucae (HP:0200043)2.01974051
84Papilloma (HP:0012740)2.01974051
85Myositis (HP:0100614)2.01170438
86Thrombocytosis (HP:0001894)2.00750330
87Prolonged bleeding time (HP:0003010)2.00173553
88Arterial thrombosis (HP:0004420)1.99466233
89Nephritis (HP:0000123)1.99428362
90Recurrent skin infections (HP:0001581)1.97467140
91Gastrointestinal stroma tumor (HP:0100723)1.97337993
92Thoracic kyphosis (HP:0002942)1.96168808
93Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95477751
94Loss of speech (HP:0002371)1.95433180
95Urinary glycosaminoglycan excretion (HP:0003541)1.94089872
96Mucopolysacchariduria (HP:0008155)1.94089872
97Vertebral compression fractures (HP:0002953)1.94023934
98Recurrent bronchitis (HP:0002837)1.93905759
99Keratoconjunctivitis (HP:0001096)1.93374741
100Hyperlipoproteinemia (HP:0010980)1.92743018
101Hepatosplenomegaly (HP:0001433)1.92739264
102Hypertensive crisis (HP:0100735)1.92597480
103Abnormality of the fingertips (HP:0001211)1.92538487
104Pulmonary embolism (HP:0002204)1.91941211
105Osteomyelitis (HP:0002754)1.90706249
106Increased connective tissue (HP:0009025)1.88884000
107Abnormal platelet volume (HP:0011876)1.87891209
108Pathologic fracture (HP:0002756)1.87093909
109Hypercholesterolemia (HP:0003124)1.87080405
110Abnormality of iron homeostasis (HP:0011031)1.86857323
111Flat acetabular roof (HP:0003180)1.86229682
112Reticulocytosis (HP:0001923)1.85304131
113Lymphangioma (HP:0100764)1.82825342
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82651900
115Ulnar bowing (HP:0003031)1.82641133
116Obstructive sleep apnea (HP:0002870)1.82330590
117Aneurysm (HP:0002617)1.82288366
118Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82275211
119Menorrhagia (HP:0000132)1.82216798
120Restrictive lung disease (HP:0002091)1.82138523
121Abnormality of T cell physiology (HP:0011840)1.81939187
122Increased cerebral lipofuscin (HP:0011813)1.81838774
123Microcytic anemia (HP:0001935)1.81746136
124Urticaria (HP:0001025)1.81599704
125Periodontitis (HP:0000704)1.81247699
126Osteolytic defects of the hand bones (HP:0009699)1.81103625
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.81103625
128Distal lower limb muscle weakness (HP:0009053)1.80873987
129Hypoglycemic coma (HP:0001325)1.80826836
130Hyperammonemia (HP:0001987)1.80681226
131Abnormality of the thoracic spine (HP:0100711)1.79616608
132Acne (HP:0001061)1.78732096
133Disproportionate tall stature (HP:0001519)1.78055392
134Episodic fever (HP:0001954)1.77578185
135Abnormality of the peritoneum (HP:0002585)1.77288786
136Conjunctival telangiectasia (HP:0000524)1.76534462
137Mesangial abnormality (HP:0001966)1.76480856
138Late onset (HP:0003584)1.76455341
139Abnormality of T cells (HP:0002843)1.74707410
140Thrombophlebitis (HP:0004418)1.74209895
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73837187
142Abnormality of polysaccharide metabolism (HP:0011012)1.73837187
143Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73837187
144Hypergammaglobulinemia (HP:0010702)1.73714972
145Petechiae (HP:0000967)1.73568769
146Emphysema (HP:0002097)1.73316605
147Hyperacusis (HP:0010780)1.73243024
148Nonimmune hydrops fetalis (HP:0001790)1.72970525
149Increased density of long bones (HP:0006392)1.72740440
150Anorexia (HP:0002039)1.72640973
151Thin bony cortex (HP:0002753)1.72606093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.82613188
2ERN13.60306546
3MAP3K103.19077155
4PKN23.06856468
5RIPK42.97023297
6PRPF4B2.73583711
7EEF2K2.63424610
8* MAP4K12.62703732
9KDR2.50964850
10SMG12.40400872
11EPHB12.29510820
12TGFBR22.23021819
13TIE12.22300846
14PTK61.96890422
15TNK21.95903711
16STK101.93581497
17TBK11.91959886
18MAP2K31.90388695
19TYK21.87486424
20FGFR41.84000809
21BLK1.83338683
22ZAP701.81681996
23LRRK21.67911435
24FES1.67883223
25JAK31.63690650
26TTN1.57874085
27PRKD21.55378662
28RIPK11.52097617
29MAP3K131.51797885
30SIK11.47147375
31GRK61.41669069
32TAOK21.37839113
33KIT1.32903807
34MARK21.32227517
35FLT31.29788708
36BTK1.29692617
37CSK1.22234074
38CSF1R1.22184589
39RPS6KA41.21272981
40FGR1.20801346
41TGFBR11.15279641
42MAP3K31.15110825
43CDK121.14697172
44CDC42BPA1.13763006
45BMX1.11892695
46MST1R1.10045371
47PAK41.08802803
48BCKDK1.05820486
49IKBKE1.05729503
50CAMK1D1.04926570
51PDPK11.02799434
52TAOK31.01445546
53EPHA21.00131054
54MAP2K20.98548967
55JAK10.97599536
56SIK30.95821317
57SCYL20.94869007
58TAOK10.94170263
59ITK0.93665020
60IRAK20.93448784
61MATK0.90317177
62JAK20.88571453
63HCK0.88565266
64ICK0.87867374
65MAP3K80.87849757
66* MAP3K10.85866744
67CDK40.83660116
68IKBKB0.80005403
69MAP3K140.78824811
70NEK20.78242417
71CDK60.77724928
72CHUK0.76638846
73RPS6KA20.75703966
74DMPK0.75348324
75PDK10.74354676
76LCK0.73692615
77MAP3K60.73549510
78RPS6KC10.73133953
79RPS6KL10.73133953
80PIM10.72770007
81IRAK10.72291592
82IRAK30.72205777
83MARK30.72130586
84MAP3K70.71955969
85* MAP3K110.71635330
86KSR20.70758280
87STK40.68562732
88MAPK110.67224710
89NLK0.65929907
90SYK0.65298218
91IRAK40.65110568
92MTOR0.64488368
93RPS6KB20.63833971
94PRKG20.63756082
95MAPK120.63272824
96PTK20.63025703
97NME20.63012169
98FGFR30.60511905
99CLK10.59350459
100MET0.58759787
101TESK20.58059527
102DYRK1B0.56795715
103CAMK1G0.55643814
104MAP2K60.54975412
105TEC0.54960015
106MAPKAPK30.53876387
107HIPK20.53503654
108MAPK150.52393738
109DDR20.51227531
110PDGFRB0.50530860
111MAPK70.50247046
112EPHA30.49759491
113TXK0.49028133
114CAMKK10.47403436
115PRKD10.46902809
116MAPKAPK20.43333599
117NEK90.43202250
118PIM20.42969558
119ILK0.42371396
120PTK2B0.41513591
121ARAF0.41332270
122EGFR0.41287926
123PRKCH0.41114730
124SIK20.41077289
125FYN0.40777779
126RPS6KA60.39984901
127PRKD30.39326848
128PAK20.38440170
129PRKAA20.38258997
130LYN0.37625388
131TESK10.37330685
132RET0.36948416
133ALK0.36750644

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.65246685
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23305949
3Nitrogen metabolism_Homo sapiens_hsa009102.16136573
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03249543
5Complement and coagulation cascades_Homo sapiens_hsa046101.87585533
6Leishmaniasis_Homo sapiens_hsa051401.82266020
7Allograft rejection_Homo sapiens_hsa053301.81671750
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.74007786
9Arginine biosynthesis_Homo sapiens_hsa002201.71324588
10Fatty acid degradation_Homo sapiens_hsa000711.69616377
11Graft-versus-host disease_Homo sapiens_hsa053321.66341725
12B cell receptor signaling pathway_Homo sapiens_hsa046621.65387868
13Osteoclast differentiation_Homo sapiens_hsa043801.61357202
14Caffeine metabolism_Homo sapiens_hsa002321.60331995
15Autoimmune thyroid disease_Homo sapiens_hsa053201.59255948
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55459978
17Primary immunodeficiency_Homo sapiens_hsa053401.52488717
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46954872
19Toxoplasmosis_Homo sapiens_hsa051451.39317848
20Acute myeloid leukemia_Homo sapiens_hsa052211.38978988
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35487161
22PPAR signaling pathway_Homo sapiens_hsa033201.34091470
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.30710434
24Chronic myeloid leukemia_Homo sapiens_hsa052201.28168761
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.27692443
26Lysine degradation_Homo sapiens_hsa003101.27164041
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.24023841
28Tryptophan metabolism_Homo sapiens_hsa003801.23655953
29ABC transporters_Homo sapiens_hsa020101.17617748
30Fat digestion and absorption_Homo sapiens_hsa049751.17329523
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17189898
32Measles_Homo sapiens_hsa051621.17128320
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16954210
34Sulfur relay system_Homo sapiens_hsa041221.16016931
35Pertussis_Homo sapiens_hsa051331.15036702
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12884053
37Asthma_Homo sapiens_hsa053101.11888628
38Other glycan degradation_Homo sapiens_hsa005111.10315309
39Legionellosis_Homo sapiens_hsa051341.09449843
40Small cell lung cancer_Homo sapiens_hsa052221.09396707
41Antigen processing and presentation_Homo sapiens_hsa046121.09114479
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07815285
43Type I diabetes mellitus_Homo sapiens_hsa049401.07380865
44Insulin resistance_Homo sapiens_hsa049311.06296069
45Selenocompound metabolism_Homo sapiens_hsa004501.06036013
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03774505
47Fructose and mannose metabolism_Homo sapiens_hsa000511.01491465
48Bladder cancer_Homo sapiens_hsa052191.00190491
49African trypanosomiasis_Homo sapiens_hsa051430.99793289
50Phagosome_Homo sapiens_hsa041450.99590582
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.97157533
52Hematopoietic cell lineage_Homo sapiens_hsa046400.96608351
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.96260459
54Pentose phosphate pathway_Homo sapiens_hsa000300.96133830
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94860891
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94056220
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.93316300
58Apoptosis_Homo sapiens_hsa042100.93010198
59Shigellosis_Homo sapiens_hsa051310.92602334
60Histidine metabolism_Homo sapiens_hsa003400.90259900
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.89670646
62Starch and sucrose metabolism_Homo sapiens_hsa005000.89640741
63Bile secretion_Homo sapiens_hsa049760.89223685
64Prion diseases_Homo sapiens_hsa050200.88847633
65Rheumatoid arthritis_Homo sapiens_hsa053230.88588811
66Viral myocarditis_Homo sapiens_hsa054160.87638292
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87050576
68Lysosome_Homo sapiens_hsa041420.86896575
69Fatty acid metabolism_Homo sapiens_hsa012120.86778360
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.86552184
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84600623
72Malaria_Homo sapiens_hsa051440.84581792
73Influenza A_Homo sapiens_hsa051640.83421404
74Notch signaling pathway_Homo sapiens_hsa043300.83195069
75Carbon metabolism_Homo sapiens_hsa012000.81516953
76Herpes simplex infection_Homo sapiens_hsa051680.80617643
77beta-Alanine metabolism_Homo sapiens_hsa004100.80371608
78Peroxisome_Homo sapiens_hsa041460.79443173
79Pancreatic cancer_Homo sapiens_hsa052120.79387886
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.78974496
81Renal cell carcinoma_Homo sapiens_hsa052110.78940167
82Folate biosynthesis_Homo sapiens_hsa007900.78640567
83TNF signaling pathway_Homo sapiens_hsa046680.78587079
84T cell receptor signaling pathway_Homo sapiens_hsa046600.78535177
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78015285
86Platelet activation_Homo sapiens_hsa046110.77992377
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76169026
88Hepatitis B_Homo sapiens_hsa051610.75729077
89Amoebiasis_Homo sapiens_hsa051460.75469792
90Endocytosis_Homo sapiens_hsa041440.75399275
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73305135
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72745913
93Propanoate metabolism_Homo sapiens_hsa006400.72457959
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72449047
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.72446954
96Tuberculosis_Homo sapiens_hsa051520.71692473
97VEGF signaling pathway_Homo sapiens_hsa043700.71348806
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.70699493
99GnRH signaling pathway_Homo sapiens_hsa049120.70523184
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69725080
101Endometrial cancer_Homo sapiens_hsa052130.69456599
102Hepatitis C_Homo sapiens_hsa051600.69052914
103Biosynthesis of amino acids_Homo sapiens_hsa012300.69049327
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68571176
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64010780
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61595129
107mTOR signaling pathway_Homo sapiens_hsa041500.60626656
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60152120
109Insulin signaling pathway_Homo sapiens_hsa049100.59780246
110Salmonella infection_Homo sapiens_hsa051320.59297050
111Choline metabolism in cancer_Homo sapiens_hsa052310.59016600
112HIF-1 signaling pathway_Homo sapiens_hsa040660.57567889
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.57523299
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57241720
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56713215
116Chemokine signaling pathway_Homo sapiens_hsa040620.56321258
117Galactose metabolism_Homo sapiens_hsa000520.56095888
118Viral carcinogenesis_Homo sapiens_hsa052030.55894089
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.55617850
120Non-small cell lung cancer_Homo sapiens_hsa052230.55459232
121Epstein-Barr virus infection_Homo sapiens_hsa051690.55408737
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54262912
123Focal adhesion_Homo sapiens_hsa045100.54032550
124Proteoglycans in cancer_Homo sapiens_hsa052050.53466570
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53252068
126HTLV-I infection_Homo sapiens_hsa051660.51814885
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51758851
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50694326
129Prolactin signaling pathway_Homo sapiens_hsa049170.50198212
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49772302
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49533503
132Inositol phosphate metabolism_Homo sapiens_hsa005620.48203258
133ErbB signaling pathway_Homo sapiens_hsa040120.48098937
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48008734
135Estrogen signaling pathway_Homo sapiens_hsa049150.47234236
136Renin-angiotensin system_Homo sapiens_hsa046140.47200090
137Thyroid cancer_Homo sapiens_hsa052160.45312543
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45288349

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »