MAP3K13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.37759814
2L-phenylalanine catabolic process (GO:0006559)4.16724807
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.16724807
4vocalization behavior (GO:0071625)4.06897619
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.01540793
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.91752502
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81873515
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79427752
9L-phenylalanine metabolic process (GO:0006558)3.79427752
10pyrimidine nucleobase catabolic process (GO:0006208)3.79294696
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.76228394
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.75369107
13epithelial cilium movement (GO:0003351)3.68521268
14neurotransmitter-gated ion channel clustering (GO:0072578)3.65509054
15aromatic amino acid family catabolic process (GO:0009074)3.61522150
16regulation of bile acid biosynthetic process (GO:0070857)3.60415896
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.60052329
18protein localization to cilium (GO:0061512)3.59536562
19synaptic vesicle maturation (GO:0016188)3.53101683
20nucleobase catabolic process (GO:0046113)3.52784790
21synaptic vesicle exocytosis (GO:0016079)3.52399823
22limb bud formation (GO:0060174)3.51985884
23nonmotile primary cilium assembly (GO:0035058)3.50893480
24water-soluble vitamin biosynthetic process (GO:0042364)3.47544794
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.46484209
26intraciliary transport (GO:0042073)3.46309358
27ATP synthesis coupled proton transport (GO:0015986)3.43688209
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43688209
29presynaptic membrane assembly (GO:0097105)3.41771683
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.41703150
31regulation of synaptic vesicle exocytosis (GO:2000300)3.40744147
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.39533235
33bile acid biosynthetic process (GO:0006699)3.39491739
34gamma-aminobutyric acid transport (GO:0015812)3.39437229
35glutamate secretion (GO:0014047)3.38325627
36drug catabolic process (GO:0042737)3.38295257
37urea cycle (GO:0000050)3.37860218
38urea metabolic process (GO:0019627)3.37860218
39neurotransmitter secretion (GO:0007269)3.34795907
40cellular potassium ion homeostasis (GO:0030007)3.28200060
41glutamate metabolic process (GO:0006536)3.26817903
42high-density lipoprotein particle remodeling (GO:0034375)3.25895703
43protein complex biogenesis (GO:0070271)3.24172532
44protein localization to synapse (GO:0035418)3.22733896
45presynaptic membrane organization (GO:0097090)3.22710395
46locomotory exploration behavior (GO:0035641)3.22331284
47regulation of cilium movement (GO:0003352)3.22159636
48intestinal cholesterol absorption (GO:0030299)3.19926656
49kynurenine metabolic process (GO:0070189)3.19489943
50dicarboxylic acid biosynthetic process (GO:0043650)3.19072544
51tryptophan catabolic process (GO:0006569)3.17349412
52indole-containing compound catabolic process (GO:0042436)3.17349412
53indolalkylamine catabolic process (GO:0046218)3.17349412
54retinal ganglion cell axon guidance (GO:0031290)3.16069784
55alpha-linolenic acid metabolic process (GO:0036109)3.15973377
56regulation of glutamate receptor signaling pathway (GO:1900449)3.14312570
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10214939
58indolalkylamine metabolic process (GO:0006586)3.09273112
59cilium movement (GO:0003341)3.08837022
60neuron cell-cell adhesion (GO:0007158)3.05788431
61neural tube formation (GO:0001841)3.05776112
62positive regulation of synapse maturation (GO:0090129)3.04905288
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03860922
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.01712424
65NADH dehydrogenase complex assembly (GO:0010257)3.01712424
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01712424
67cellular ketone body metabolic process (GO:0046950)3.01557069
68regulation of synaptic vesicle transport (GO:1902803)3.00472345
69nitrogen cycle metabolic process (GO:0071941)2.99813947
70L-fucose catabolic process (GO:0042355)2.99338784
71fucose catabolic process (GO:0019317)2.99338784
72L-fucose metabolic process (GO:0042354)2.99338784
73reverse cholesterol transport (GO:0043691)2.99108331
74mitochondrial respiratory chain complex assembly (GO:0033108)2.97277492
75cholesterol efflux (GO:0033344)2.96254067
76bile acid metabolic process (GO:0008206)2.96176682
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93992971
78cilium morphogenesis (GO:0060271)2.92692789
79cilium organization (GO:0044782)2.91632885
80exogenous drug catabolic process (GO:0042738)2.91580455
81electron transport chain (GO:0022900)2.90767320
82tryptophan metabolic process (GO:0006568)2.90282872
83axoneme assembly (GO:0035082)2.89722379
84synaptic transmission, glutamatergic (GO:0035249)2.89531063
85glutamate receptor signaling pathway (GO:0007215)2.89310346
86cilium assembly (GO:0042384)2.89107008
87regulation of cholesterol esterification (GO:0010872)2.88795026
88layer formation in cerebral cortex (GO:0021819)2.88770497
89respiratory electron transport chain (GO:0022904)2.88524258
90somite development (GO:0061053)2.86536105
91neuron fate determination (GO:0048664)2.85876813
92cysteine metabolic process (GO:0006534)2.85341654
93ionotropic glutamate receptor signaling pathway (GO:0035235)2.85216458
94postsynaptic membrane organization (GO:0001941)2.84498465
95protein-lipid complex remodeling (GO:0034368)2.84172828
96macromolecular complex remodeling (GO:0034367)2.84172828
97plasma lipoprotein particle remodeling (GO:0034369)2.84172828
98neuron-neuron synaptic transmission (GO:0007270)2.83985313
99establishment of protein localization to mitochondrial membrane (GO:0090151)2.81500030
100phospholipid efflux (GO:0033700)2.78933730
101glyoxylate metabolic process (GO:0046487)2.77421187
102negative regulation of fibrinolysis (GO:0051918)2.77223427
103startle response (GO:0001964)2.76743511
104sequestering of actin monomers (GO:0042989)2.76001419
105dicarboxylic acid catabolic process (GO:0043649)2.75540368
106response to pheromone (GO:0019236)2.75400991
107regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75114246
108neurotransmitter transport (GO:0006836)2.74844506
109triglyceride homeostasis (GO:0070328)2.73271477
110acylglycerol homeostasis (GO:0055090)2.73271477
111negative regulation of cholesterol transport (GO:0032375)2.73181826
112negative regulation of sterol transport (GO:0032372)2.73181826
113cerebellar Purkinje cell differentiation (GO:0021702)2.71392362
114regulation of cholesterol homeostasis (GO:2000188)2.71251212
115behavioral response to ethanol (GO:0048149)2.69851168
116behavioral response to cocaine (GO:0048148)2.69536543
117serine family amino acid catabolic process (GO:0009071)2.69180729
118coenzyme catabolic process (GO:0009109)2.67764445
119kidney morphogenesis (GO:0060993)2.67473316
120regulation of fibrinolysis (GO:0051917)2.67438493
121cornea development in camera-type eye (GO:0061303)2.67368636
122dendritic spine morphogenesis (GO:0060997)2.67129936
123axonal fasciculation (GO:0007413)2.66512680
124respiratory chain complex IV assembly (GO:0008535)2.66170534
125homocysteine metabolic process (GO:0050667)2.65888908
126regulation of neuronal synaptic plasticity (GO:0048168)2.65787199
127regulation of protein activation cascade (GO:2000257)2.65198836
128detection of light stimulus involved in sensory perception (GO:0050962)2.64717600
129detection of light stimulus involved in visual perception (GO:0050908)2.64717600
130membrane hyperpolarization (GO:0060081)2.64519238
131regulation of triglyceride catabolic process (GO:0010896)2.64312116
132transmission of nerve impulse (GO:0019226)2.64135343
133neuronal action potential (GO:0019228)2.63128015
134alpha-amino acid catabolic process (GO:1901606)2.63067549
135alanine transport (GO:0032328)2.61519114
136sodium ion export (GO:0071436)2.60365938
137cellular biogenic amine catabolic process (GO:0042402)2.60066192
138amine catabolic process (GO:0009310)2.60066192
139ketone body metabolic process (GO:1902224)2.59028434
140regulation of synapse structural plasticity (GO:0051823)2.58450419
141serotonin metabolic process (GO:0042428)2.58297008
142bile acid and bile salt transport (GO:0015721)2.57345202
143intestinal absorption (GO:0050892)2.55794777
144complement activation, alternative pathway (GO:0006957)2.55616017
145regulation of neurotransmitter levels (GO:0001505)2.55271631
146dendrite morphogenesis (GO:0048813)2.55093040
147lysine metabolic process (GO:0006553)2.55080441
148lysine catabolic process (GO:0006554)2.55080441
149platelet dense granule organization (GO:0060155)2.54832942
150cellular modified amino acid catabolic process (GO:0042219)2.53725109
151indole-containing compound metabolic process (GO:0042430)2.53438350
152prepulse inhibition (GO:0060134)2.53416185
153cerebellar granule cell differentiation (GO:0021707)2.52548078
154primary amino compound metabolic process (GO:1901160)2.52344402
155regulation of glucokinase activity (GO:0033131)2.51215395
156regulation of hexokinase activity (GO:1903299)2.51215395
157negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50675440
158sulfur amino acid catabolic process (GO:0000098)2.50136469
159protein-cofactor linkage (GO:0018065)2.49764385
160regulation of long-term neuronal synaptic plasticity (GO:0048169)2.49727644
161mannosylation (GO:0097502)2.48969135
162negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48847548
163spinal cord motor neuron differentiation (GO:0021522)2.46874271
164preassembly of GPI anchor in ER membrane (GO:0016254)2.46377539
165neuron recognition (GO:0008038)2.45191401
166photoreceptor cell development (GO:0042461)2.41567501
167axonemal dynein complex assembly (GO:0070286)2.41507675
168smoothened signaling pathway (GO:0007224)2.40993829
169membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40805031
170regulation of action potential (GO:0098900)2.40454277
171auditory behavior (GO:0031223)2.40414189
172cilium or flagellum-dependent cell motility (GO:0001539)2.39656195
173nephron tubule morphogenesis (GO:0072078)2.39071713
174nephron epithelium morphogenesis (GO:0072088)2.39071713
175protein neddylation (GO:0045116)2.37899254
176photoreceptor cell maintenance (GO:0045494)2.34315287
177limb development (GO:0060173)2.33324907
178appendage development (GO:0048736)2.33324907
179reflex (GO:0060004)2.32632295
180cytochrome complex assembly (GO:0017004)2.32508026
181positive regulation of oligodendrocyte differentiation (GO:0048714)2.31947799
182inner ear receptor stereocilium organization (GO:0060122)2.31709682
183protein polyglutamylation (GO:0018095)2.31590573
184negative regulation of astrocyte differentiation (GO:0048712)2.31495735
185spinal cord development (GO:0021510)2.30121256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.74710880
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.44233236
3GBX2_23144817_ChIP-Seq_PC3_Human3.20773769
4ZNF274_21170338_ChIP-Seq_K562_Hela2.91737429
5VDR_22108803_ChIP-Seq_LS180_Human2.73053560
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.56144818
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41561973
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37746161
9FUS_26573619_Chip-Seq_HEK293_Human2.35034665
10DROSHA_22980978_ChIP-Seq_HELA_Human2.23944440
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23447220
12REST_21632747_ChIP-Seq_MESCs_Mouse2.19409731
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.15721479
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12496908
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09295489
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09295489
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09133377
18EWS_26573619_Chip-Seq_HEK293_Human2.05626190
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03962483
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02877365
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00580909
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00005796
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98108373
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97750763
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96600104
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.96312466
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93094197
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.84413831
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.83753422
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.83246260
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82412930
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81013936
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.80091596
34TAF15_26573619_Chip-Seq_HEK293_Human1.80065826
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.78552794
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78009533
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77218942
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.74308814
39ER_23166858_ChIP-Seq_MCF-7_Human1.72949796
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71978600
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.71640836
42AR_21572438_ChIP-Seq_LNCaP_Human1.71254587
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64270931
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60924153
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60403188
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.59857909
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56211966
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55467325
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54520821
50RNF2_27304074_Chip-Seq_NSC_Mouse1.52822706
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51820021
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47288235
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46923161
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.46344426
55SMAD4_21799915_ChIP-Seq_A2780_Human1.45851449
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45586464
57CBP_20019798_ChIP-Seq_JUKART_Human1.45586464
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44132217
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43555120
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43478047
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42100660
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.39149499
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.38854228
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36342705
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31584458
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31130398
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.30024667
68TCF4_22108803_ChIP-Seq_LS180_Human1.29868271
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.28838807
70P300_19829295_ChIP-Seq_ESCs_Human1.26013778
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25141217
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25091935
73* SOX2_19829295_ChIP-Seq_ESCs_Human1.23435301
74* NANOG_19829295_ChIP-Seq_ESCs_Human1.23435301
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.22902954
76STAT3_23295773_ChIP-Seq_U87_Human1.22295709
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21395462
78* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20865259
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19636805
80TP53_22573176_ChIP-Seq_HFKS_Human1.19308830
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19023546
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18197742
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17377297
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16475126
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.16149069
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16028787
87IRF1_19129219_ChIP-ChIP_H3396_Human1.16018975
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.15944021
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15133049
90AR_19668381_ChIP-Seq_PC3_Human1.14447913
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.13591972
92AR_25329375_ChIP-Seq_VCAP_Human1.13306360
93P53_22387025_ChIP-Seq_ESCs_Mouse1.12264395
94ELK1_19687146_ChIP-ChIP_HELA_Human1.11883802
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11430718
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.11307582
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.10603563
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10510846
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10376923
100AHR_22903824_ChIP-Seq_MCF-7_Human1.08990844
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08386415
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08282390
103* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08280909
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08046178
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.07743098
106MYC_18940864_ChIP-ChIP_HL60_Human1.06733300
107* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06622901
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06179832
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05460567
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04565163
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.04565163
112* SMAD4_21741376_ChIP-Seq_HESCs_Human1.04341761
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04335672
114HTT_18923047_ChIP-ChIP_STHdh_Human1.03443694
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02421716
116* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02188144
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01986255
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01776580
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01510644
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.01246658
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.01239016
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00897216
123BCAT_22108803_ChIP-Seq_LS180_Human1.00850780
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.00722702
125* TCF4_23295773_ChIP-Seq_U87_Human1.00573285
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.00476055
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.00409195
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99068638
129* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98960394
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98687753
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98005729
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.97603817
133POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96732498
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96534406
135IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95363620
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.95219485
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95162541
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95004232
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93698629
140* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93095711
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92986993
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92766336
143* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91890569
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90002439
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90002439
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88904865
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88201866
148TP53_16413492_ChIP-PET_HCT116_Human0.88151761
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87084891
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.85523554
151IGF1R_20145208_ChIP-Seq_DFB_Human0.84884684
152RUNX2_22187159_ChIP-Seq_PCA_Human0.84720457
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84583775
154* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84163363
155THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83640574
156TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83315786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.97545603
2MP0002139_abnormal_hepatobiliary_system4.54279880
3MP0004859_abnormal_synaptic_plasticity3.86277367
4MP0005085_abnormal_gallbladder_physiolo3.72695031
5MP0005365_abnormal_bile_salt3.55628843
6MP0002822_catalepsy3.39515276
7MP0008875_abnormal_xenobiotic_pharmacok3.19666010
8MP0003880_abnormal_central_pattern2.80349473
9MP0004270_analgesia2.79557684
10MP0003136_yellow_coat_color2.78175253
11MP0003635_abnormal_synaptic_transmissio2.75923448
12MP0003252_abnormal_bile_duct2.48362363
13MP0009745_abnormal_behavioral_response2.35217436
14MP0002063_abnormal_learning/memory/cond2.33895865
15MP0010329_abnormal_lipoprotein_level2.25981079
16MP0009046_muscle_twitch2.24568656
17MP0001666_abnormal_nutrient_absorption2.24222296
18MP0000569_abnormal_digit_pigmentation2.21193581
19MP0005423_abnormal_somatic_nervous2.19997632
20MP0002638_abnormal_pupillary_reflex2.17077580
21MP0002064_seizures2.16842937
22MP0002938_white_spotting2.07594205
23MP0006072_abnormal_retinal_apoptosis1.98210681
24MP0002572_abnormal_emotion/affect_behav1.96940654
25MP0001968_abnormal_touch/_nociception1.94336017
26MP0005551_abnormal_eye_electrophysiolog1.92714189
27MP0008877_abnormal_DNA_methylation1.89189040
28MP0002734_abnormal_mechanical_nocicepti1.88915263
29MP0001486_abnormal_startle_reflex1.88816708
30MP0002272_abnormal_nervous_system1.84699989
31MP0003787_abnormal_imprinting1.80210741
32MP0006292_abnormal_olfactory_placode1.75133799
33MP0002102_abnormal_ear_morphology1.73138419
34MP0000631_abnormal_neuroendocrine_gland1.67653156
35MP0001501_abnormal_sleep_pattern1.66390612
36MP0005083_abnormal_biliary_tract1.63675675
37MP0002653_abnormal_ependyma_morphology1.63619396
38MP0003122_maternal_imprinting1.61576855
39MP0003329_amyloid_beta_deposits1.55674260
40MP0001984_abnormal_olfaction1.55217375
41MP0005332_abnormal_amino_acid1.51719860
42MP0000566_synostosis1.50514653
43MP0003879_abnormal_hair_cell1.48939561
44MP0003868_abnormal_feces_composition1.46880352
45MP0000372_irregular_coat_pigmentation1.46023100
46MP0002067_abnormal_sensory_capabilities1.45879579
47MP0009780_abnormal_chondrocyte_physiolo1.44158950
48MP0001485_abnormal_pinna_reflex1.43499505
49MP0002735_abnormal_chemical_nociception1.43424485
50MP0002736_abnormal_nociception_after1.42601787
51MP0001440_abnormal_grooming_behavior1.40740294
52MP0003121_genomic_imprinting1.39144257
53MP0008995_early_reproductive_senescence1.37912385
54MP0001502_abnormal_circadian_rhythm1.37854779
55MP0002184_abnormal_innervation1.37579621
56MP0004019_abnormal_vitamin_homeostasis1.36073326
57MP0002557_abnormal_social/conspecific_i1.35604616
58MP0000778_abnormal_nervous_system1.33491609
59MP0004885_abnormal_endolymph1.33457700
60MP0002837_dystrophic_cardiac_calcinosis1.30771702
61MP0008789_abnormal_olfactory_epithelium1.29594454
62MP0004742_abnormal_vestibular_system1.28664034
63MP0004924_abnormal_behavior1.28300312
64MP0005386_behavior/neurological_phenoty1.28300312
65MP0002118_abnormal_lipid_homeostasis1.28020825
66MP0002163_abnormal_gland_morphology1.24522538
67MP0006276_abnormal_autonomic_nervous1.22953430
68MP0004133_heterotaxia1.22317400
69MP0001986_abnormal_taste_sensitivity1.22261243
70MP0002234_abnormal_pharynx_morphology1.22172884
71MP0005379_endocrine/exocrine_gland_phen1.20741558
72MP0003283_abnormal_digestive_organ1.20217251
73MP0001905_abnormal_dopamine_level1.20034062
74MP0003011_delayed_dark_adaptation1.18154499
75MP0008569_lethality_at_weaning1.18118762
76MP0005646_abnormal_pituitary_gland1.18035284
77MP0002733_abnormal_thermal_nociception1.18014588
78MP0002090_abnormal_vision1.17898552
79MP0002751_abnormal_autonomic_nervous1.17819944
80MP0004858_abnormal_nervous_system1.15856278
81MP0009840_abnormal_foam_cell1.15507679
82MP0002229_neurodegeneration1.12387962
83MP0004811_abnormal_neuron_physiology1.12355101
84MP0000026_abnormal_inner_ear1.11813868
85MP0009379_abnormal_foot_pigmentation1.11505418
86MP0002909_abnormal_adrenal_gland1.10390965
87MP0002928_abnormal_bile_duct1.09690432
88MP0001970_abnormal_pain_threshold1.09569186
89MP0003633_abnormal_nervous_system1.09369376
90MP0005174_abnormal_tail_pigmentation1.09335031
91MP0000427_abnormal_hair_cycle1.08468132
92MP0000955_abnormal_spinal_cord1.06326656
93MP0008872_abnormal_physiological_respon1.04612370
94MP0004142_abnormal_muscle_tone1.04389900
95MP0002882_abnormal_neuron_morphology1.04176415
96MP0002876_abnormal_thyroid_physiology1.03296181
97MP0001188_hyperpigmentation1.02027254
98MP0005367_renal/urinary_system_phenotyp1.01692404
99MP0000516_abnormal_urinary_system1.01692404
100MP0002066_abnormal_motor_capabilities/c1.01080751
101MP0000647_abnormal_sebaceous_gland1.01060308
102MP0000604_amyloidosis0.99127795
103MP0002277_abnormal_respiratory_mucosa0.98184825
104MP0003890_abnormal_embryonic-extraembry0.97806955
105MP0005645_abnormal_hypothalamus_physiol0.96954677
106MP0002069_abnormal_eating/drinking_beha0.96910083
107MP0003938_abnormal_ear_development0.96550177
108MP0003195_calcinosis0.96540047
109MP0001529_abnormal_vocalization0.95798223
110MP0004043_abnormal_pH_regulation0.95740296
111MP0002095_abnormal_skin_pigmentation0.95219820
112MP0004147_increased_porphyrin_level0.93696585
113MP0005535_abnormal_body_temperature0.92593143
114MP0005171_absent_coat_pigmentation0.92040517
115MP0003806_abnormal_nucleotide_metabolis0.90520541
116MP0003631_nervous_system_phenotype0.89791802
117MP0001324_abnormal_eye_pigmentation0.89163424
118MP0005584_abnormal_enzyme/coenzyme_acti0.87451534
119MP0001177_atelectasis0.86407565
120MP0000049_abnormal_middle_ear0.83565297
121MP0002282_abnormal_trachea_morphology0.82493907
122MP0005448_abnormal_energy_balance0.81019792
123MP0008874_decreased_physiological_sensi0.80790319
124MP0003690_abnormal_glial_cell0.80392163
125MP0005084_abnormal_gallbladder_morpholo0.80052319
126MP0002152_abnormal_brain_morphology0.78664348
127MP0000609_abnormal_liver_physiology0.77371840
128MP0009697_abnormal_copulation0.76776674
129MP0003183_abnormal_peptide_metabolism0.76541810
130MP0005499_abnormal_olfactory_system0.76043643
131MP0005394_taste/olfaction_phenotype0.76043643
132MP0001764_abnormal_homeostasis0.75608097
133MP0005253_abnormal_eye_physiology0.71650561
134MP0002078_abnormal_glucose_homeostasis0.67840335
135MP0005187_abnormal_penis_morphology0.67628033
136MP0004233_abnormal_muscle_weight0.66784129
137MP0004085_abnormal_heartbeat0.66535567
138MP0005248_abnormal_Harderian_gland0.65990197
139MP0005195_abnormal_posterior_eye0.65989701
140MP0008961_abnormal_basal_metabolism0.65882117
141MP0002752_abnormal_somatic_nervous0.65530639
142MP0003632_abnormal_nervous_system0.63269781
143MP0005319_abnormal_enzyme/_coenzyme0.63049404
144MP0001664_abnormal_digestion0.62082695
145MP0010386_abnormal_urinary_bladder0.61720412

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.14575224
2Hypobetalipoproteinemia (HP:0003563)4.47377419
3Intrahepatic cholestasis (HP:0001406)4.42929182
4Myokymia (HP:0002411)4.33086781
5Deep venous thrombosis (HP:0002625)4.18938035
6Pancreatic cysts (HP:0001737)4.06084702
7True hermaphroditism (HP:0010459)3.91810081
8Focal seizures (HP:0007359)3.89862782
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.87831892
10Pancreatic fibrosis (HP:0100732)3.70095462
11Molar tooth sign on MRI (HP:0002419)3.69897691
12Abnormality of midbrain morphology (HP:0002418)3.69897691
13Xanthomatosis (HP:0000991)3.67173544
14Medial flaring of the eyebrow (HP:0010747)3.62584155
15Febrile seizures (HP:0002373)3.58079632
16Nephronophthisis (HP:0000090)3.56908577
17Epileptic encephalopathy (HP:0200134)3.50166370
18Epidermoid cyst (HP:0200040)3.48018255
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.46871524
20Progressive cerebellar ataxia (HP:0002073)3.42590811
21Conjugated hyperbilirubinemia (HP:0002908)3.42123731
22Hyperventilation (HP:0002883)3.41925183
23Congenital stationary night blindness (HP:0007642)3.30290152
24Prolonged partial thromboplastin time (HP:0003645)3.27763606
25Absence seizures (HP:0002121)3.14935557
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09061104
27Hypolipoproteinemia (HP:0010981)3.08669773
28Gait imbalance (HP:0002141)3.04491697
29Abnormality of the renal medulla (HP:0100957)3.03137827
30Acute necrotizing encephalopathy (HP:0006965)3.02862232
31Hyperlipoproteinemia (HP:0010980)3.01702253
32Congenital, generalized hypertrichosis (HP:0004540)2.90270667
33Dysdiadochokinesis (HP:0002075)2.89996331
34Scanning speech (HP:0002168)2.88349975
35Congenital primary aphakia (HP:0007707)2.88060172
36Visual hallucinations (HP:0002367)2.87966691
37Action tremor (HP:0002345)2.85878372
38Acanthocytosis (HP:0001927)2.82607982
39Central scotoma (HP:0000603)2.81946198
40Progressive macrocephaly (HP:0004481)2.79461608
41Hypothermia (HP:0002045)2.79168495
42Fat malabsorption (HP:0002630)2.78368864
43Generalized tonic-clonic seizures (HP:0002069)2.77752461
44Impaired social interactions (HP:0000735)2.73419362
45Abnormal social behavior (HP:0012433)2.73419362
46Status epilepticus (HP:0002133)2.72771305
47Complement deficiency (HP:0004431)2.72610100
48Dialeptic seizures (HP:0011146)2.71028355
49Mitochondrial inheritance (HP:0001427)2.69127718
50Dysmetric saccades (HP:0000641)2.67287920
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65042676
52Genital tract atresia (HP:0001827)2.64495103
53Nephrogenic diabetes insipidus (HP:0009806)2.63419902
54Abnormality of the lower motor neuron (HP:0002366)2.59857542
55Vaginal atresia (HP:0000148)2.59413347
56Acute encephalopathy (HP:0006846)2.59008868
57Ketosis (HP:0001946)2.58915383
58Abnormality of the renal cortex (HP:0011035)2.57951705
59Atonic seizures (HP:0010819)2.57790094
60Cystic liver disease (HP:0006706)2.56740157
61Genetic anticipation (HP:0003743)2.51849151
62Abnormal mitochondria in muscle tissue (HP:0008316)2.50353428
63Poor eye contact (HP:0000817)2.48104416
64Impaired vibration sensation in the lower limbs (HP:0002166)2.48031531
65Large for gestational age (HP:0001520)2.47172007
66Limb dystonia (HP:0002451)2.45271072
67Hyperammonemia (HP:0001987)2.44608985
68Hyperglycinemia (HP:0002154)2.42831967
69Gaze-evoked nystagmus (HP:0000640)2.41059201
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.40723331
71Increased CSF lactate (HP:0002490)2.40616506
72Torticollis (HP:0000473)2.39418494
73Gout (HP:0001997)2.38276950
74Epileptiform EEG discharges (HP:0011182)2.37811918
75Postural instability (HP:0002172)2.37654544
76Abnormal gallbladder physiology (HP:0012438)2.37531136
77Cholecystitis (HP:0001082)2.37531136
78Abnormal respiratory epithelium morphology (HP:0012253)2.36404151
79Abnormal respiratory motile cilium morphology (HP:0005938)2.36404151
80Urinary bladder sphincter dysfunction (HP:0002839)2.36316521
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.36127070
82Absent/shortened dynein arms (HP:0200106)2.36127070
83EEG with generalized epileptiform discharges (HP:0011198)2.34558945
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33603872
85Abnormal ciliary motility (HP:0012262)2.32971778
86Abnormality of the labia minora (HP:0012880)2.32949138
87Hypoalphalipoproteinemia (HP:0003233)2.32888112
883-Methylglutaconic aciduria (HP:0003535)2.31158621
89Male pseudohermaphroditism (HP:0000037)2.29878297
90Sclerocornea (HP:0000647)2.28130739
91Chronic hepatic failure (HP:0100626)2.27824032
92Abnormality of macular pigmentation (HP:0008002)2.26557804
93Dysmetria (HP:0001310)2.25156483
94Focal dystonia (HP:0004373)2.23921094
95Tubular atrophy (HP:0000092)2.23721180
96Abnormality of glycine metabolism (HP:0010895)2.21108737
97Abnormality of serine family amino acid metabolism (HP:0010894)2.21108737
98Broad-based gait (HP:0002136)2.20496862
99Intention tremor (HP:0002080)2.18456851
100Ankle clonus (HP:0011448)2.17631433
101Truncal ataxia (HP:0002078)2.17551654
102Craniofacial dystonia (HP:0012179)2.17543172
103Supranuclear gaze palsy (HP:0000605)2.17414306
104Abnormal respiratory motile cilium physiology (HP:0012261)2.16441617
105Postaxial hand polydactyly (HP:0001162)2.15731144
106Intestinal atresia (HP:0011100)2.15496054
107Abnormal eating behavior (HP:0100738)2.15378141
108Impaired vibratory sensation (HP:0002495)2.15341633
109Hemiparesis (HP:0001269)2.14268229
110Hyperglycinuria (HP:0003108)2.14115997
111Spastic gait (HP:0002064)2.13623183
112Increased hepatocellular lipid droplets (HP:0006565)2.12714360
113Hypercholesterolemia (HP:0003124)2.12487419
114Neurofibrillary tangles (HP:0002185)2.12149681
115Hypsarrhythmia (HP:0002521)2.11488102
116Drooling (HP:0002307)2.10900248
117Excessive salivation (HP:0003781)2.10900248
118Attenuation of retinal blood vessels (HP:0007843)2.10810765
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10541662
120Depression (HP:0000716)2.09289539
121Postaxial foot polydactyly (HP:0001830)2.09206981
122Anxiety (HP:0000739)2.08771964
123Abnormality of the corticospinal tract (HP:0002492)2.08256228
124Concave nail (HP:0001598)2.08106030
125Polydipsia (HP:0001959)2.07954305
126Abnormal drinking behavior (HP:0030082)2.07954305
127Congenital hepatic fibrosis (HP:0002612)2.07874965
128Pigmentary retinal degeneration (HP:0001146)2.07835802
129Lipid accumulation in hepatocytes (HP:0006561)2.05657062
130Aplasia/Hypoplasia of the tongue (HP:0010295)2.04585830
131Abnormality of the common coagulation pathway (HP:0010990)2.03952844
132Hepatocellular necrosis (HP:0001404)2.03361941
133Anencephaly (HP:0002323)2.02365566
134Ketoacidosis (HP:0001993)2.02328597
135Termporal pattern (HP:0011008)2.01958412
136Insidious onset (HP:0003587)2.01958412
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01208807
138Abnormality of alanine metabolism (HP:0010916)2.01208807
139Hyperalaninemia (HP:0003348)2.01208807
140Hepatic necrosis (HP:0002605)1.99519245
141Confusion (HP:0001289)1.99377997
142Optic disc pallor (HP:0000543)1.99181001
143Sensorimotor neuropathy (HP:0007141)1.98943977
144Furrowed tongue (HP:0000221)1.98524994
145Abolished electroretinogram (ERG) (HP:0000550)1.98354607
146Skin nodule (HP:0200036)1.96920501
147Oligodactyly (hands) (HP:0001180)1.96587606
148Cerebral inclusion bodies (HP:0100314)1.96290311
149Pheochromocytoma (HP:0002666)1.95913643
150Morphological abnormality of the pyramidal tract (HP:0002062)1.95489808
151Poor coordination (HP:0002370)1.95382396
152Lissencephaly (HP:0001339)1.95362824
153Decreased central vision (HP:0007663)1.92848527
154Renal cortical cysts (HP:0000803)1.91963576
155Congenital sensorineural hearing impairment (HP:0008527)1.91135119
156Pendular nystagmus (HP:0012043)1.90845218
157Inability to walk (HP:0002540)1.89880582
158Type II lissencephaly (HP:0007260)1.89812124
159Hyperbilirubinemia (HP:0002904)1.89779431
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.87751093
161Rhinitis (HP:0012384)1.87660430
162Blue irides (HP:0000635)1.87039043
163Bony spicule pigmentary retinopathy (HP:0007737)1.86806919
164Abnormality of methionine metabolism (HP:0010901)1.86533796
165Abnormal rod and cone electroretinograms (HP:0008323)1.86464635
166Scotoma (HP:0000575)1.85647397
167Abnormal gallbladder morphology (HP:0012437)1.85282037
168Fair hair (HP:0002286)1.84751346
169Absent speech (HP:0001344)1.84160732
170Hemiplegia (HP:0002301)1.83571524
171Cholelithiasis (HP:0001081)1.82913571
172Increased corneal curvature (HP:0100692)1.82779150
173Keratoconus (HP:0000563)1.82779150
174Polyphagia (HP:0002591)1.82473537
175Renal Fanconi syndrome (HP:0001994)1.80452746
176Cerebral edema (HP:0002181)1.78577667
177Glycosuria (HP:0003076)1.78436795
178Abnormality of urine glucose concentration (HP:0011016)1.78436795
179Median cleft lip (HP:0000161)1.77013221
180Widely spaced teeth (HP:0000687)1.74693742
181Specific learning disability (HP:0001328)1.74566837
182Pachygyria (HP:0001302)1.74441574
183Anophthalmia (HP:0000528)1.74149954
184Preaxial hand polydactyly (HP:0001177)1.73222228
185Optic nerve hypoplasia (HP:0000609)1.71634601
186Abnormal sex determination (HP:0012244)1.69375734
187Sex reversal (HP:0012245)1.69375734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.63195830
2EPHA43.51978029
3MAP3K43.29521962
4NTRK33.29246227
5MAP3K93.27824112
6AKT32.70725435
7MAP2K42.44770340
8DAPK22.44495356
9MAP2K72.42324659
10BMPR1B2.37892054
11MAP4K22.27558510
12NUAK12.14995473
13ADRBK22.09261547
14PNCK2.09084731
15CASK2.04902627
16MINK12.04778013
17GRK12.03897308
18PAK61.93566641
19NTRK21.92306947
20ZAK1.74836618
21SGK4941.71457432
22SGK2231.71457432
23ACVR1B1.69532741
24MAPK151.67512824
25DYRK21.66678286
26SGK21.61967399
27RIPK11.57689806
28WNK41.55111640
29PRPF4B1.43386805
30TAOK31.40222809
31CAMKK11.39269594
32TRIM281.38388025
33BCR1.38088502
34MST41.36500431
35SGK31.36305576
36STK391.33139008
37MAPK131.27762520
38KSR21.26834588
39KSR11.26410585
40CDK51.26100499
41EPHA31.25482946
42FGFR21.25358787
43NTRK11.21844833
44WEE11.19133899
45ERBB31.17121056
46STK381.14304276
47PRKCG1.11074683
48TNIK1.09352385
49VRK11.09087781
50MAP3K71.08675586
51FRK1.07817356
52TLK11.07523855
53MKNK21.07212748
54ERBB41.02604067
55SIK21.01181486
56CSNK1G11.01008957
57INSRR0.99176928
58PHKG10.98258269
59PHKG20.98258269
60DYRK1A0.98130449
61PINK10.95902011
62CAMK2A0.94765871
63LMTK20.94372116
64OXSR10.93391207
65CAMK1G0.93141582
66CSNK1G30.92436038
67STK38L0.91020495
68VRK20.90667604
69ADRBK10.87778544
70PRKD30.87141633
71MAP3K120.86652224
72MARK20.86172849
73EPHB20.85805090
74FGFR40.85070330
75BRSK20.84997664
76DAPK10.84823597
77PRKCZ0.84620991
78SIK10.80755340
79RET0.80402413
80CAMK2B0.77744751
81CSNK1A1L0.77383227
82MST1R0.77324797
83TGFBR10.77198458
84CSNK1G20.76170391
85ICK0.75724058
86TYRO30.74505833
87TAOK10.73698815
88SGK10.73287093
89MAP3K130.72947543
90PAK30.72814218
91CAMK40.72256150
92DYRK30.71461534
93UHMK10.71116496
94MAP3K20.70600869
95CAMKK20.68323869
96CDK180.67334441
97MKNK10.67137510
98CDK150.66494596
99STK110.66300513
100CAMK2G0.65217119
101BRAF0.65119620
102CDK190.64632996
103LATS10.64566108
104CAMK10.64181696
105MAP3K60.63412933
106WNK30.62291144
107FER0.62121241
108FES0.61788823
109PRKCH0.60889963
110ARAF0.60319155
111PLK30.59937127
112PDPK10.59618297
113PLK20.59505666
114RPS6KA30.58920146
115CSNK1A10.58110979
116CDK140.57930818
117PIK3CA0.57930568
118BCKDK0.57930419
119ERBB20.57840786
120CCNB10.56454398
121PRKAA10.56155294
122PKN10.55900744
123NEK10.55097551
124CDK30.54912710
125CAMK2D0.54865906
126LATS20.54727785
127CDK11A0.54077289
128PRKACA0.53624271
129PRKCE0.52590534
130PDK10.52335360
131GRK50.51869121
132STK160.51304020
133MAP3K10.49736616
134CAMK1D0.49312151
135MAP2K10.48929004
136NME10.48564815
137PRKG10.46544848
138MAPK120.45681909
139PRKCB0.44391176
140RIPK40.43811403
141PRKACG0.43477800
142MAPKAPK50.42842047
143TAOK20.42309790
144MAP2K60.39944992
145RPS6KA50.39742748
146PRKACB0.39304975
147EIF2AK30.37733081
148CSNK1E0.36543898
149SRPK10.34147698
150PTK2B0.32645742
151PRKCA0.32482030
152TSSK60.31943897
153IRAK10.30759349
154CSNK1D0.29985995
155ROCK10.27693489

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.53392715
2Oxidative phosphorylation_Homo sapiens_hsa001903.49874732
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.94412959
4Parkinsons disease_Homo sapiens_hsa050122.78395230
5Protein export_Homo sapiens_hsa030602.73870436
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.64338046
7Arginine biosynthesis_Homo sapiens_hsa002202.49773789
8Nicotine addiction_Homo sapiens_hsa050332.43830053
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03656684
10Huntingtons disease_Homo sapiens_hsa050161.98021405
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95498555
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95420861
13Alzheimers disease_Homo sapiens_hsa050101.90768885
14GABAergic synapse_Homo sapiens_hsa047271.90680043
15Butanoate metabolism_Homo sapiens_hsa006501.90371316
16Synaptic vesicle cycle_Homo sapiens_hsa047211.89303398
17Linoleic acid metabolism_Homo sapiens_hsa005911.87710901
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86257596
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82234427
20Bile secretion_Homo sapiens_hsa049761.80128673
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70246993
22Cardiac muscle contraction_Homo sapiens_hsa042601.68035879
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64993408
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64333365
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63331745
26Tryptophan metabolism_Homo sapiens_hsa003801.61712820
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59310130
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58108661
29Ribosome_Homo sapiens_hsa030101.58005075
30RNA polymerase_Homo sapiens_hsa030201.54381803
31Circadian entrainment_Homo sapiens_hsa047131.49295101
32Morphine addiction_Homo sapiens_hsa050321.46852175
33Glutamatergic synapse_Homo sapiens_hsa047241.46834293
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46262134
35Fatty acid degradation_Homo sapiens_hsa000711.45974867
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44706793
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43290907
38Fat digestion and absorption_Homo sapiens_hsa049751.41606918
39Complement and coagulation cascades_Homo sapiens_hsa046101.29997197
40PPAR signaling pathway_Homo sapiens_hsa033201.26739556
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26521033
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25684938
43Ether lipid metabolism_Homo sapiens_hsa005651.23178511
44Olfactory transduction_Homo sapiens_hsa047401.19888334
45Fatty acid metabolism_Homo sapiens_hsa012121.17969732
46Insulin secretion_Homo sapiens_hsa049111.16007045
47Histidine metabolism_Homo sapiens_hsa003401.15802514
48Salivary secretion_Homo sapiens_hsa049701.15691182
49Basal transcription factors_Homo sapiens_hsa030221.13162484
50Peroxisome_Homo sapiens_hsa041461.10589081
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10101491
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10010183
53Phototransduction_Homo sapiens_hsa047441.09668681
54Collecting duct acid secretion_Homo sapiens_hsa049661.09514388
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08967366
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08743645
57Dopaminergic synapse_Homo sapiens_hsa047281.08400132
58Amphetamine addiction_Homo sapiens_hsa050311.08171806
59Long-term potentiation_Homo sapiens_hsa047201.06167831
60Proteasome_Homo sapiens_hsa030501.04707944
61beta-Alanine metabolism_Homo sapiens_hsa004101.03656384
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.01647665
63ABC transporters_Homo sapiens_hsa020101.00902235
64Cholinergic synapse_Homo sapiens_hsa047250.98871028
65Homologous recombination_Homo sapiens_hsa034400.98312287
66Sulfur metabolism_Homo sapiens_hsa009200.97988735
67Vitamin digestion and absorption_Homo sapiens_hsa049770.97188742
68Selenocompound metabolism_Homo sapiens_hsa004500.95144892
69Taste transduction_Homo sapiens_hsa047420.94775327
70Chemical carcinogenesis_Homo sapiens_hsa052040.94266474
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92969586
72Starch and sucrose metabolism_Homo sapiens_hsa005000.92871305
73Propanoate metabolism_Homo sapiens_hsa006400.92736988
74Caffeine metabolism_Homo sapiens_hsa002320.92693236
75Retinol metabolism_Homo sapiens_hsa008300.90372740
76RNA degradation_Homo sapiens_hsa030180.88826523
77Fanconi anemia pathway_Homo sapiens_hsa034600.88198794
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87698385
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87515739
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.85736680
81Renin secretion_Homo sapiens_hsa049240.85394178
82Pyruvate metabolism_Homo sapiens_hsa006200.83918767
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83348214
84Phenylalanine metabolism_Homo sapiens_hsa003600.83019048
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82597607
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80954367
87Glycerolipid metabolism_Homo sapiens_hsa005610.80891730
88Cocaine addiction_Homo sapiens_hsa050300.80562588
89Type II diabetes mellitus_Homo sapiens_hsa049300.79492071
90Serotonergic synapse_Homo sapiens_hsa047260.77610387
91Long-term depression_Homo sapiens_hsa047300.76989314
92Gastric acid secretion_Homo sapiens_hsa049710.76290076
93Hedgehog signaling pathway_Homo sapiens_hsa043400.72928865
94Arachidonic acid metabolism_Homo sapiens_hsa005900.71201664
95Steroid biosynthesis_Homo sapiens_hsa001000.70219344
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69520279
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69161328
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.68046615
99Biosynthesis of amino acids_Homo sapiens_hsa012300.67455567
100Metabolic pathways_Homo sapiens_hsa011000.67246176
101Tyrosine metabolism_Homo sapiens_hsa003500.66957521
102Fatty acid biosynthesis_Homo sapiens_hsa000610.66506413
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66239345
104Ovarian steroidogenesis_Homo sapiens_hsa049130.65990194
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.65927853
106Calcium signaling pathway_Homo sapiens_hsa040200.65735185
107Oxytocin signaling pathway_Homo sapiens_hsa049210.62913927
108Circadian rhythm_Homo sapiens_hsa047100.60804015
109Regulation of autophagy_Homo sapiens_hsa041400.60774523
110Lysine degradation_Homo sapiens_hsa003100.58716701
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.56130731
112Mineral absorption_Homo sapiens_hsa049780.55421946
113Fatty acid elongation_Homo sapiens_hsa000620.54365022
114Gap junction_Homo sapiens_hsa045400.53150919
115Pancreatic secretion_Homo sapiens_hsa049720.53039676
116GnRH signaling pathway_Homo sapiens_hsa049120.52268825
117Basal cell carcinoma_Homo sapiens_hsa052170.52019338
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51372212
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50823050
120cAMP signaling pathway_Homo sapiens_hsa040240.50123486
121Glutathione metabolism_Homo sapiens_hsa004800.49994221
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49770175
123Arginine and proline metabolism_Homo sapiens_hsa003300.48662731
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48419135
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48357774
126Carbon metabolism_Homo sapiens_hsa012000.47754737
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46378946
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45012876
129Purine metabolism_Homo sapiens_hsa002300.44822583
130Thyroid hormone synthesis_Homo sapiens_hsa049180.44246720
131Axon guidance_Homo sapiens_hsa043600.44195262
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.44028293
133ErbB signaling pathway_Homo sapiens_hsa040120.41402332
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41313507
135Glucagon signaling pathway_Homo sapiens_hsa049220.40426436
136Folate biosynthesis_Homo sapiens_hsa007900.33723202

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