MAP3K14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.27242351
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.74766524
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.74766524
4positive regulation of gamma-delta T cell activation (GO:0046645)5.62652442
5* NIK/NF-kappaB signaling (GO:0038061)5.14513699
6regulation of interleukin-12 biosynthetic process (GO:0045075)5.08686117
7negative thymic T cell selection (GO:0045060)5.06191241
8negative T cell selection (GO:0043383)5.03184487
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.96314576
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.96314576
11modulation by symbiont of host immune response (GO:0052553)4.96314576
12positive regulation by symbiont of host defense response (GO:0052509)4.96314576
13modulation by symbiont of host defense response (GO:0052031)4.96314576
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.96314576
15regulation of gamma-delta T cell differentiation (GO:0045586)4.84580477
16positive thymic T cell selection (GO:0045059)4.62463014
17regulation of gamma-delta T cell activation (GO:0046643)4.60477663
18macrophage activation involved in immune response (GO:0002281)4.54741572
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.49205028
20response to muramyl dipeptide (GO:0032495)4.32321037
21thymic T cell selection (GO:0045061)4.25431220
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.17508615
23regulation of alpha-beta T cell proliferation (GO:0046640)4.17016231
24regulation of dendritic cell antigen processing and presentation (GO:0002604)4.15178072
25response to interleukin-15 (GO:0070672)4.13958957
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08200278
27negative regulation of cell killing (GO:0031342)4.08200278
28detection of bacterium (GO:0016045)4.03648466
29T cell selection (GO:0045058)4.02813565
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00723555
31regulation of T cell tolerance induction (GO:0002664)4.00571209
32cellular response to interleukin-15 (GO:0071350)3.99917973
33positive regulation of antigen processing and presentation (GO:0002579)3.95232634
34detection of other organism (GO:0098543)3.91580963
35positive regulation of alpha-beta T cell proliferation (GO:0046641)3.91143883
36interferon-gamma production (GO:0032609)3.89726494
37positive T cell selection (GO:0043368)3.88513016
38positive regulation of interleukin-2 production (GO:0032743)3.86633967
39myeloid dendritic cell differentiation (GO:0043011)3.84121944
40JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.82824556
41regulation of B cell receptor signaling pathway (GO:0050855)3.80740257
42T cell migration (GO:0072678)3.79545676
43interferon-gamma-mediated signaling pathway (GO:0060333)3.69066239
44positive regulation of interleukin-12 production (GO:0032735)3.68833804
45myeloid dendritic cell activation (GO:0001773)3.67414101
46CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.65903242
47positive regulation of natural killer cell differentiation (GO:0032825)3.62101799
48tolerance induction (GO:0002507)3.60702709
49regulation of T-helper 1 cell differentiation (GO:0045625)3.60518883
50response to type I interferon (GO:0034340)3.59062891
51cellular response to type I interferon (GO:0071357)3.56529430
52type I interferon signaling pathway (GO:0060337)3.56529430
53regulation of memory T cell differentiation (GO:0043380)3.50492137
54regulation of antigen processing and presentation (GO:0002577)3.49090389
55positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.48953562
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.48110811
57regulation of type I interferon-mediated signaling pathway (GO:0060338)3.46643500
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.44409147
59positive regulation of B cell differentiation (GO:0045579)3.43699104
60B cell homeostasis (GO:0001782)3.41057187
61growth hormone receptor signaling pathway (GO:0060396)3.39979705
62regulation of natural killer cell mediated immunity (GO:0002715)3.38485971
63regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.38485971
64regulation of interleukin-2 biosynthetic process (GO:0045076)3.37207310
65regulation of response to interferon-gamma (GO:0060330)3.35052036
66regulation of B cell differentiation (GO:0045577)3.33571250
67regulation of T cell mediated cytotoxicity (GO:0001914)3.33416314
68positive regulation of T cell mediated cytotoxicity (GO:0001916)3.32536200
69positive regulation of interferon-alpha production (GO:0032727)3.26327937
70negative regulation of T cell mediated immunity (GO:0002710)3.26085368
71regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.25777610
72germinal center formation (GO:0002467)3.24393721
73response to protozoan (GO:0001562)3.21427632
74B cell receptor signaling pathway (GO:0050853)3.18710668
75leukocyte aggregation (GO:0070486)3.17348109
76immunoglobulin mediated immune response (GO:0016064)3.17309192
77regulation of interleukin-12 production (GO:0032655)3.16342861
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16320012
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.16312246
80response to host immune response (GO:0052572)3.16312246
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15720532
82positive regulation of humoral immune response (GO:0002922)3.15487899
83regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.13829819
84antigen processing and presentation via MHC class Ib (GO:0002475)3.12931180
85response to host (GO:0075136)3.12271008
86response to host defenses (GO:0052200)3.12271008
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12271008
88negative regulation of interleukin-12 production (GO:0032695)3.10426735
89negative regulation of leukocyte mediated immunity (GO:0002704)3.10337372
90positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09470499
91dendritic cell differentiation (GO:0097028)3.09233363
92regulation of interferon-alpha production (GO:0032647)3.08765991
93natural killer cell activation (GO:0030101)3.05674410
94neutrophil activation (GO:0042119)3.05509624
95response to peptidoglycan (GO:0032494)3.05197049
96positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.04424611
97positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.03148597
98B cell mediated immunity (GO:0019724)3.02773931
99CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.01705410
100T-helper cell differentiation (GO:0042093)3.01705410
101positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.99238145
102regulation of T cell receptor signaling pathway (GO:0050856)2.98630138
103positive regulation of isotype switching (GO:0045830)2.97754263
104myeloid cell activation involved in immune response (GO:0002275)2.96009246
105T-helper 1 type immune response (GO:0042088)2.95220525
106regulation of tolerance induction (GO:0002643)2.93777695
107detection of external biotic stimulus (GO:0098581)2.93663050
108production of molecular mediator involved in inflammatory response (GO:0002532)2.93290223
109granulocyte activation (GO:0036230)2.92285734
110positive regulation of T-helper cell differentiation (GO:0045624)2.92278389
111negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91221750
112regulation of interferon-beta biosynthetic process (GO:0045357)2.91109783
113* T cell costimulation (GO:0031295)2.89545360
114regulation of regulatory T cell differentiation (GO:0045589)2.89155662
115neutrophil activation involved in immune response (GO:0002283)2.88961311
116positive regulation of T-helper 1 type immune response (GO:0002827)2.88832249
117cellular response to growth hormone stimulus (GO:0071378)2.88824845
118mature B cell differentiation (GO:0002335)2.88056177
119regulation of leukocyte mediated cytotoxicity (GO:0001910)2.87727011
120regulation of interleukin-2 production (GO:0032663)2.87641095
121antigen receptor-mediated signaling pathway (GO:0050851)2.86809004
122negative regulation of innate immune response (GO:0045824)2.86226671
123regulation of T-helper cell differentiation (GO:0045622)2.84699920
124T cell receptor signaling pathway (GO:0050852)2.84685503
125positive regulation of type 2 immune response (GO:0002830)2.84135924
126lymphocyte migration (GO:0072676)2.83874941
127positive regulation of T cell differentiation (GO:0045582)2.83651384
128natural killer cell differentiation (GO:0001779)2.83147304
129* lymphocyte costimulation (GO:0031294)2.83079209
130positive regulation of natural killer cell activation (GO:0032816)2.83067036
131regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.82735251
132activated T cell proliferation (GO:0050798)2.82729196
133regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.82225054
134lymphocyte homeostasis (GO:0002260)2.82129133
135regulation of cell killing (GO:0031341)2.82098215
136regulation of RIG-I signaling pathway (GO:0039535)2.81933454
137defense response to protozoan (GO:0042832)2.80280579
138negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80277392
139negative regulation of T-helper cell differentiation (GO:0045623)2.80277392
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.79084749
141JAK-STAT cascade (GO:0007259)2.76869961
142positive regulation of alpha-beta T cell differentiation (GO:0046638)2.76194932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.20814040
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.86803285
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.25590497
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.15144749
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.99982546
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.66061213
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.60018573
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.34153794
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30745336
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.22565070
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14942585
12RUNX_20019798_ChIP-Seq_JUKART_Human3.05203278
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03000882
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96685076
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.90717130
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.87678452
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.84519091
18MYC_22102868_ChIP-Seq_BL_Human2.82518076
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76579491
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.67177846
21* MYB_26560356_Chip-Seq_TH2_Human2.60864787
22* MAF_26560356_Chip-Seq_TH1_Human2.53194299
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.47454381
24MYB_26560356_Chip-Seq_TH1_Human2.34818865
25VDR_21846776_ChIP-Seq_THP-1_Human2.33397926
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32944676
27SCL_19346495_ChIP-Seq_HPC-7_Human2.27553621
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17096803
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.11219681
30TCF7_22412390_ChIP-Seq_EML_Mouse2.04837582
31UTX_26944678_Chip-Seq_JUKART_Human2.04348889
32* LXR_22292898_ChIP-Seq_THP-1_Human1.99431098
33VDR_24763502_ChIP-Seq_THP-1_Human1.95527196
34* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93508820
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91949439
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91539237
37SPI1_23127762_ChIP-Seq_K562_Human1.83184896
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82089088
39* SPI1_23547873_ChIP-Seq_NB4_Human1.81026207
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.77819351
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77726128
42* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77617204
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74976956
44KDM2B_26808549_Chip-Seq_DND41_Human1.69880372
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69822758
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65790508
47GATA3_27048872_Chip-Seq_THYMUS_Human1.62478314
48* MAF_26560356_Chip-Seq_TH2_Human1.59531806
49* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57327957
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56177407
51BCL6_27268052_Chip-Seq_Bcells_Human1.55722435
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.55263070
53* CIITA_25753668_ChIP-Seq_RAJI_Human1.53768430
54BCOR_27268052_Chip-Seq_Bcells_Human1.51318797
55* PU_27001747_Chip-Seq_BMDM_Mouse1.49176227
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48694896
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.47506013
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43038061
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41685823
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.40451994
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35523476
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.35471315
63VDR_24787735_ChIP-Seq_THP-1_Human1.30634559
64* P68_20966046_ChIP-Seq_HELA_Human1.26096203
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24435989
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.19878799
67* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19491165
68* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17487164
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15991470
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15404023
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13239615
72* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10333540
73* SMC4_20622854_ChIP-Seq_HELA_Human1.09980265
74* RACK7_27058665_Chip-Seq_MCF-7_Human1.09317408
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.08681903
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.08617839
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08383607
78* GATA3_26560356_Chip-Seq_TH2_Human1.08209552
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07718777
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06309124
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.05540410
82* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05320785
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04063621
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03324133
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02731550
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02400640
87E2F1_20622854_ChIP-Seq_HELA_Human1.02359454
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02270136
89P300_27268052_Chip-Seq_Bcells_Human1.02202037
90* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99347064
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98283651
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.98209275
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97907220
94SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97593932
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.97460930
96PHF8_20622854_ChIP-Seq_HELA_Human0.97433831
97* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97156706
98* NCOR1_26117541_ChIP-Seq_K562_Human0.95577523
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94890186
100GATA1_22025678_ChIP-Seq_K562_Human0.94468995
101KDM2B_26808549_Chip-Seq_K562_Human0.94360873
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90659517
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85790626
104* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84019860
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83385014
106STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80304245
107SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78625712
108* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78311107
109* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77401810
110SMRT_27268052_Chip-Seq_Bcells_Human0.76596737
111* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76226857
112GATA1_19941826_ChIP-Seq_K562_Human0.74757469
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74151801
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73978221
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72979672
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72965927
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72574451
118* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72510445
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72063281
120* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71890398
121* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71890398
122* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70758883
123* GATA2_19941826_ChIP-Seq_K562_Human0.69606571
124* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67214462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.39135515
2* MP0000685_abnormal_immune_system3.86159973
3MP0004510_myositis3.47782310
4* MP0001790_abnormal_immune_system3.37670204
5* MP0005387_immune_system_phenotype3.37670204
6* MP0001800_abnormal_humoral_immune3.16970152
7* MP0005671_abnormal_response_to3.06754350
8MP0005000_abnormal_immune_tolerance3.06489150
9MP0003436_decreased_susceptibility_to2.92861109
10MP0003763_abnormal_thymus_physiology2.89680150
11* MP0002452_abnormal_antigen_presenting2.78363262
12MP0009785_altered_susceptibility_to2.70768928
13* MP0002723_abnormal_immune_serum2.67911462
14MP0002148_abnormal_hypersensitivity_rea2.61195017
15* MP0001819_abnormal_immune_cell2.50499289
16* MP0002420_abnormal_adaptive_immunity2.49620050
17MP0002166_altered_tumor_susceptibility2.48927886
18* MP0005025_abnormal_response_to2.45082960
19MP0003303_peritoneal_inflammation2.40920789
20MP0001873_stomach_inflammation2.35046338
21MP0002419_abnormal_innate_immunity2.31563866
22MP0005310_abnormal_salivary_gland2.22561403
23MP0003300_gastrointestinal_ulcer2.20826429
24MP0001853_heart_inflammation2.19948827
25* MP0002398_abnormal_bone_marrow2.18928474
26MP0002254_reproductive_system_inflammat2.16059961
27* MP0002405_respiratory_system_inflammati2.14048489
28* MP0002138_abnormal_hepatobiliary_system2.09183537
29* MP0000716_abnormal_immune_system2.08750285
30MP0010155_abnormal_intestine_physiology2.01677299
31MP0003724_increased_susceptibility_to1.99553081
32MP0002006_tumorigenesis1.98792332
33MP0006082_CNS_inflammation1.97872150
34MP0004947_skin_inflammation1.97625179
35MP0009333_abnormal_splenocyte_physiolog1.81361100
36* MP0000689_abnormal_spleen_morphology1.74179359
37* MP0002722_abnormal_immune_system1.72935186
38MP0002396_abnormal_hematopoietic_system1.70109360
39* MP0001845_abnormal_inflammatory_respons1.69316340
40* MP0002429_abnormal_blood_cell1.64561796
41MP0005464_abnormal_platelet_physiology1.64380472
42MP0005451_abnormal_body_composition1.62778883
43MP0004808_abnormal_hematopoietic_stem1.58760851
44* MP0000703_abnormal_thymus_morphology1.56766772
45MP0000569_abnormal_digit_pigmentation1.54036883
46MP0003866_abnormal_defecation1.49568354
47MP0001533_abnormal_skeleton_physiology1.41437001
48MP0002933_joint_inflammation1.36611414
49MP0009840_abnormal_foam_cell1.36442872
50MP0009278_abnormal_bone_marrow1.35514102
51MP0003448_altered_tumor_morphology1.34147593
52MP0000858_altered_metastatic_potential1.28736670
53MP0004381_abnormal_hair_follicle1.27339129
54MP0010352_gastrointestinal_tract_polyps1.25521663
55MP0002163_abnormal_gland_morphology1.21067224
56* MP0008469_abnormal_protein_level1.20809129
57MP0003045_fibrosis1.17621030
58MP0008260_abnormal_autophagy1.15905066
59MP0005397_hematopoietic_system_phenotyp1.15645282
60MP0001545_abnormal_hematopoietic_system1.15645282
61MP0003453_abnormal_keratinocyte_physiol1.13204272
62MP0005076_abnormal_cell_differentiation1.12401797
63MP0003091_abnormal_cell_migration1.11227490
64MP0002277_abnormal_respiratory_mucosa1.11037718
65MP0003183_abnormal_peptide_metabolism1.10744190
66MP0009764_decreased_sensitivity_to1.09880229
67MP0000465_gastrointestinal_hemorrhage1.09152857
68MP0002998_abnormal_bone_remodeling1.08907502
69MP0001663_abnormal_digestive_system1.05655196
70MP0005174_abnormal_tail_pigmentation1.04465352
71* MP0001348_abnormal_lacrimal_gland1.01543093
72MP0002877_abnormal_melanocyte_morpholog0.98213356
73MP0001851_eye_inflammation0.96386834
74MP0008057_abnormal_DNA_replication0.95357953
75MP0005058_abnormal_lysosome_morphology0.90777446
76MP0003828_pulmonary_edema0.89540870
77MP0003172_abnormal_lysosome_physiology0.88179461
78MP0000015_abnormal_ear_pigmentation0.87494159
79MP0005166_decreased_susceptibility_to0.83924709
80MP0002139_abnormal_hepatobiliary_system0.82018641
81MP0002009_preneoplasia0.81750971
82MP0005379_endocrine/exocrine_gland_phen0.81102422
83MP0010307_abnormal_tumor_latency0.81003429
84MP0000490_abnormal_crypts_of0.80144786
85MP0003566_abnormal_cell_adhesion0.79230831
86MP0008961_abnormal_basal_metabolism0.77660940
87* MP0002928_abnormal_bile_duct0.75252944
88MP0000733_abnormal_muscle_development0.72391448
89MP0005390_skeleton_phenotype0.71948257
90MP0005023_abnormal_wound_healing0.71573208
91MP0001881_abnormal_mammary_gland0.70880237
92MP0009115_abnormal_fat_cell0.70300041
93MP0000249_abnormal_blood_vessel0.69827179
94MP0004130_abnormal_muscle_cell0.68498879
95MP0003075_altered_response_to0.66947274
96MP0009763_increased_sensitivity_to0.66204846
97MP0002019_abnormal_tumor_incidence0.66096514
98* MP0002136_abnormal_kidney_physiology0.62785054
99MP0005360_urolithiasis0.62741795
100MP0001346_abnormal_lacrimal_gland0.62443422
101MP0001986_abnormal_taste_sensitivity0.61397986
102* MP0002693_abnormal_pancreas_physiology0.61134134
103MP0005381_digestive/alimentary_phenotyp0.60441235
104MP0002132_abnormal_respiratory_system0.59684720
105MP0000767_abnormal_smooth_muscle0.59344177
106MP0001958_emphysema0.59267082
107MP0003795_abnormal_bone_structure0.57801408
108MP0008874_decreased_physiological_sensi0.57162333
109MP0003191_abnormal_cellular_cholesterol0.56795104
110* MP0000609_abnormal_liver_physiology0.56436238
111MP0010234_abnormal_vibrissa_follicle0.55988785
112MP0001216_abnormal_epidermal_layer0.54728836
113MP0000343_altered_response_to0.54385517
114MP0009765_abnormal_xenobiotic_induced0.53940425
115MP0000604_amyloidosis0.53642930
116MP0008007_abnormal_cellular_replicative0.53353500
117MP0005083_abnormal_biliary_tract0.52655343
118MP0004883_abnormal_blood_vessel0.50568477
119MP0005075_abnormal_melanosome_morpholog0.49580601
120MP0000371_diluted_coat_color0.48762863

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.32773778
2Recurrent fungal infections (HP:0002841)4.96584967
3Recurrent abscess formation (HP:0002722)4.87808231
4Recurrent bacterial skin infections (HP:0005406)4.41511360
5Chronic otitis media (HP:0000389)4.39381950
6Chronic mucocutaneous candidiasis (HP:0002728)4.32482295
7Recurrent cutaneous fungal infections (HP:0011370)4.32482295
8Myositis (HP:0100614)4.30732107
9Recurrent viral infections (HP:0004429)4.29282349
10Elevated erythrocyte sedimentation rate (HP:0003565)4.15952897
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.14004848
12Optic neuritis (HP:0100653)4.02285389
13Retrobulbar optic neuritis (HP:0100654)4.02285389
14Orchitis (HP:0100796)3.89314083
15Recurrent bronchitis (HP:0002837)3.85587245
16Recurrent skin infections (HP:0001581)3.74283064
17Nasal polyposis (HP:0100582)3.70399632
18Abnormality of T cell number (HP:0011839)3.64120048
19Agammaglobulinemia (HP:0004432)3.61975343
20Vasculitis (HP:0002633)3.61009305
21T lymphocytopenia (HP:0005403)3.50276293
22Mediastinal lymphadenopathy (HP:0100721)3.45996556
23Increased IgE level (HP:0003212)3.42194865
24Colitis (HP:0002583)3.41467712
25Stomatitis (HP:0010280)3.40043292
26Inflammation of the large intestine (HP:0002037)3.38968944
27Panhypogammaglobulinemia (HP:0003139)3.38431889
28IgM deficiency (HP:0002850)3.37272306
29Meningitis (HP:0001287)3.35384096
30Cellulitis (HP:0100658)3.23598818
31Abnormality of the nasal mucosa (HP:0000433)3.22866038
32Abnormality of the fingertips (HP:0001211)3.18121394
33Arterial thrombosis (HP:0004420)3.16590161
34Gastrointestinal inflammation (HP:0004386)3.16583872
35Pulmonary infiltrates (HP:0002113)3.12518488
36Abnormality of T cells (HP:0002843)3.06752321
37Emphysema (HP:0002097)2.97759625
38Gastrointestinal stroma tumor (HP:0100723)2.96164946
39Thrombocytosis (HP:0001894)2.88122904
40Gingivitis (HP:0000230)2.87867002
41Interstitial pulmonary disease (HP:0006530)2.86576420
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.83070494
43Lymphopenia (HP:0001888)2.82870614
44Recurrent gram-negative bacterial infections (HP:0005420)2.82034620
45Eosinophilia (HP:0001880)2.78510350
46Autoimmune thrombocytopenia (HP:0001973)2.78376364
47Hemoptysis (HP:0002105)2.75920056
48Chronic diarrhea (HP:0002028)2.75233501
49Abnormality of T cell physiology (HP:0011840)2.74018646
50Abnormality of macrophages (HP:0004311)2.72777873
51Chronic sinusitis (HP:0011109)2.68545431
52Leukocytosis (HP:0001974)2.67602400
53Gastrointestinal infarctions (HP:0005244)2.58939810
54Persistence of primary teeth (HP:0006335)2.58920184
55Myocardial infarction (HP:0001658)2.57651861
56Urticaria (HP:0001025)2.57599396
57IgG deficiency (HP:0004315)2.57445653
58Abnormality of eosinophils (HP:0001879)2.56288982
59Keratoconjunctivitis (HP:0001096)2.55679100
60Hypergammaglobulinemia (HP:0010702)2.52002763
61Keratoconjunctivitis sicca (HP:0001097)2.50222150
62IgA deficiency (HP:0002720)2.49912832
63Periodontitis (HP:0000704)2.49870504
64Hematochezia (HP:0002573)2.48826771
65Obstructive lung disease (HP:0006536)2.47553262
66Chronic obstructive pulmonary disease (HP:0006510)2.47553262
67Osteomyelitis (HP:0002754)2.45788400
68Gingival bleeding (HP:0000225)2.45785569
69Spontaneous hematomas (HP:0007420)2.44549881
70Fatigue (HP:0012378)2.43673049
71Pustule (HP:0200039)2.43274484
72Encephalitis (HP:0002383)2.42065059
73Increased IgM level (HP:0003496)2.41328558
74Thyroiditis (HP:0100646)2.40652528
75Increased density of long bones (HP:0006392)2.39500608
76Chest pain (HP:0100749)2.35693093
77Severe combined immunodeficiency (HP:0004430)2.34057906
78Joint swelling (HP:0001386)2.32688387
79Granulocytopenia (HP:0001913)2.31721423
80Verrucae (HP:0200043)2.31031628
81Papilloma (HP:0012740)2.31031628
82Hypochromic anemia (HP:0001931)2.27078580
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22398693
84Spinal cord lesions (HP:0100561)2.22186312
85Syringomyelia (HP:0003396)2.22186312
86Severe visual impairment (HP:0001141)2.19614184
87Malnutrition (HP:0004395)2.16201652
88Prolonged bleeding time (HP:0003010)2.14321863
89Slow saccadic eye movements (HP:0000514)2.13493272
90Recurrent sinusitis (HP:0011108)2.13406812
91Hypertensive crisis (HP:0100735)2.12224980
92Increased cerebral lipofuscin (HP:0011813)2.11930546
93Skin ulcer (HP:0200042)2.11026799
94Sepsis (HP:0100806)2.08926611
95Combined immunodeficiency (HP:0005387)2.08445504
96Viral hepatitis (HP:0006562)2.04962835
97Cheilitis (HP:0100825)2.04917466
98Restrictive lung disease (HP:0002091)2.02828593
99Global brain atrophy (HP:0002283)2.02422627
100Recurrent pneumonia (HP:0006532)2.02266848
101Epistaxis (HP:0000421)2.01450274
102Recurrent lower respiratory tract infections (HP:0002783)2.01392627
103Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01193963
104B lymphocytopenia (HP:0010976)1.98311677
105Abnormality of B cell number (HP:0010975)1.98311677
106Skin rash (HP:0000988)1.97127903
107Abnormality of the pleura (HP:0002103)1.95913458
108Bronchitis (HP:0012387)1.95417799
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.95055886
110Dysostosis multiplex (HP:0000943)1.95008749
111Arthralgia (HP:0002829)1.93412586
112Papilledema (HP:0001085)1.92819708
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91218232
114Spondylolisthesis (HP:0003302)1.86460158
115Acrocyanosis (HP:0001063)1.84743025
116Abnormality of liposaccharide metabolism (HP:0010968)1.84542717
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.84542717
118Abnormality of glycolipid metabolism (HP:0010969)1.84542717
119Absent frontal sinuses (HP:0002688)1.84451403
120Basal ganglia calcification (HP:0002135)1.84326163
121Loss of speech (HP:0002371)1.84001004
122Asymmetric septal hypertrophy (HP:0001670)1.83857927
123Leukopenia (HP:0001882)1.83606617
124Autoimmune hemolytic anemia (HP:0001890)1.82492138
125Lymphoma (HP:0002665)1.82322896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.42426117
2MAP4K14.15007501
3TYK23.41827242
4JAK33.35719527
5PRPF4B2.77162165
6IKBKB2.63929835
7TXK2.63558311
8TBK12.61301021
9JAK12.50071009
10IKBKE2.48393370
11FGFR42.31445855
12IRAK32.28521903
13NLK2.25133082
14CHUK2.19566154
15EPHB12.07800257
16CDK121.91957226
17EPHA31.90945129
18ZAP701.90663558
19BLK1.89533120
20IRAK41.84104981
21MAP3K131.81135163
22ITK1.74383771
23MAP3K101.68710206
24STK101.62582895
25BTK1.62097482
26GRK61.61299769
27KIT1.55843993
28FGFR31.48220997
29TGFBR21.45588131
30MAP3K111.40770203
31SYK1.39807360
32PIM11.35854332
33CSF1R1.34472606
34TEC1.33322764
35CDC42BPA1.31525586
36SMG11.31386238
37HCK1.30741856
38CSK1.30083042
39TRIB31.28952791
40LCK1.28345564
41EEF2K1.25697022
42TAOK31.17505190
43ERN11.17059997
44MARK21.12009796
45SIK21.10804315
46IRAK11.07394846
47RIPK41.07085618
48RPS6KA41.06615170
49LRRK21.06387088
50MAPK111.02434298
51JAK21.02322325
52PTK61.01094211
53HIPK20.97647933
54TAOK10.96731168
55SIK10.94336901
56MAPK120.94152530
57SIK30.91960476
58TTN0.91422106
59MAPK70.91345996
60TRPM70.89994780
61NEK90.89780720
62PIM20.88900788
63MAP2K30.88070546
64PDK10.84820562
65ICK0.80731309
66PRKCQ0.79918339
67PDPK10.76124305
68LYN0.74664840
69TESK20.74368328
70KSR20.74284995
71TLK10.72867776
72MARK30.72606685
73MAP3K10.64794658
74FES0.64313018
75DMPK0.64244558
76FLT30.62114547
77PKN20.60169247
78MST40.56901248
79DYRK1B0.56698812
80MAPKAPK20.53669296
81CDK40.53597074
82RPS6KL10.53360183
83RPS6KC10.53360183
84IRAK20.53254778
85MAP3K70.52847410
86MELK0.52097911
87RPS6KA50.51883512
88SGK30.51562149
89CDK90.50990480
90MAP2K20.50882526
91STK380.50090406
92YES10.49508049
93RPS6KA20.48297586
94STK40.47658725
95PKN10.47189622
96CDK60.46294027
97CLK10.46274046
98CAMKK10.46166799
99TAOK20.45037519
100INSR0.43564128
101PDGFRB0.43241398
102PTK2B0.42478349
103FYN0.39728155
104PRKAA20.39674722
105ABL10.37675163
106BMX0.37362148
107PRKCH0.37258669
108MAP3K30.37127604
109EGFR0.37056745
110RAF10.36678726
111MAP3K90.36446629
112RPS6KA10.35013837
113SGK20.33644330
114TGFBR10.33155438
115ARAF0.33090959
116NUAK10.32891678
117CAMK1D0.31437251
118ALK0.31417118
119MTOR0.29979605
120TNK20.29250675
121PRKCI0.29194585
122PASK0.28618253
123MST1R0.28502041
124FGR0.27855324
125PRKCD0.27760954
126MAPK30.27727354
127RPS6KA60.27490600
128BRD40.26454950
129STK240.26017295
130GSK3A0.24606008
131PRKD20.22032489
132MATK0.21795504
133BMPR20.21476986

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.33794238
2* NF-kappa B signaling pathway_Homo sapiens_hsa040643.17724657
3Leishmaniasis_Homo sapiens_hsa051402.70812134
4Measles_Homo sapiens_hsa051622.67041584
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.65962126
6* Osteoclast differentiation_Homo sapiens_hsa043802.58918940
7* Intestinal immune network for IgA production_Homo sapiens_hsa046722.48475864
8B cell receptor signaling pathway_Homo sapiens_hsa046622.47225601
9Allograft rejection_Homo sapiens_hsa053302.44901916
10Graft-versus-host disease_Homo sapiens_hsa053322.31430435
11Antigen processing and presentation_Homo sapiens_hsa046122.14703106
12* T cell receptor signaling pathway_Homo sapiens_hsa046602.05609274
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03940992
14Jak-STAT signaling pathway_Homo sapiens_hsa046302.03421636
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02927184
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98331895
17Toxoplasmosis_Homo sapiens_hsa051451.97609496
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92721766
19* TNF signaling pathway_Homo sapiens_hsa046681.84925615
20Herpes simplex infection_Homo sapiens_hsa051681.78415002
21Hematopoietic cell lineage_Homo sapiens_hsa046401.72503018
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68993729
23Influenza A_Homo sapiens_hsa051641.68769254
24Chemokine signaling pathway_Homo sapiens_hsa040621.65542291
25Legionellosis_Homo sapiens_hsa051341.59058291
26Acute myeloid leukemia_Homo sapiens_hsa052211.55975349
27Autoimmune thyroid disease_Homo sapiens_hsa053201.49269284
28* Apoptosis_Homo sapiens_hsa042101.47000770
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46977202
30Viral myocarditis_Homo sapiens_hsa054161.46407151
31Tuberculosis_Homo sapiens_hsa051521.43570492
32Malaria_Homo sapiens_hsa051441.42388461
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38745806
34Hepatitis B_Homo sapiens_hsa051611.38503118
35Chronic myeloid leukemia_Homo sapiens_hsa052201.33738200
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32462577
37Staphylococcus aureus infection_Homo sapiens_hsa051501.32020552
38Shigellosis_Homo sapiens_hsa051311.29011379
39Pertussis_Homo sapiens_hsa051331.26998336
40Prolactin signaling pathway_Homo sapiens_hsa049171.21226534
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19724776
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16348025
43Type I diabetes mellitus_Homo sapiens_hsa049401.14295652
44Pancreatic cancer_Homo sapiens_hsa052121.13706648
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.12123074
46Hepatitis C_Homo sapiens_hsa051601.08854239
47* HTLV-I infection_Homo sapiens_hsa051661.05728735
48Small cell lung cancer_Homo sapiens_hsa052221.03805538
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00635207
50* Epstein-Barr virus infection_Homo sapiens_hsa051690.98948067
51Rheumatoid arthritis_Homo sapiens_hsa053230.96828167
52Salmonella infection_Homo sapiens_hsa051320.90443864
53Viral carcinogenesis_Homo sapiens_hsa052030.89404138
54Platelet activation_Homo sapiens_hsa046110.88154725
55Asthma_Homo sapiens_hsa053100.87111507
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85531890
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.84980217
58African trypanosomiasis_Homo sapiens_hsa051430.83656816
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83337503
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81787313
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79533096
62Notch signaling pathway_Homo sapiens_hsa043300.77236362
63Other glycan degradation_Homo sapiens_hsa005110.69555995
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.67724305
65Insulin resistance_Homo sapiens_hsa049310.63590575
66* MAPK signaling pathway_Homo sapiens_hsa040100.61669595
67FoxO signaling pathway_Homo sapiens_hsa040680.61237771
68p53 signaling pathway_Homo sapiens_hsa041150.60169539
69GnRH signaling pathway_Homo sapiens_hsa049120.57575048
70Proteoglycans in cancer_Homo sapiens_hsa052050.56058640
71Amoebiasis_Homo sapiens_hsa051460.54380349
72Non-small cell lung cancer_Homo sapiens_hsa052230.52714161
73MicroRNAs in cancer_Homo sapiens_hsa052060.52522084
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52090763
75Prostate cancer_Homo sapiens_hsa052150.51429294
76Lysosome_Homo sapiens_hsa041420.51151920
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50872398
78Choline metabolism in cancer_Homo sapiens_hsa052310.48593403
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.46626402
80Endocytosis_Homo sapiens_hsa041440.46171811
81Pathways in cancer_Homo sapiens_hsa052000.45431422
82Dorso-ventral axis formation_Homo sapiens_hsa043200.44819205
83VEGF signaling pathway_Homo sapiens_hsa043700.44535040
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44244808
85mTOR signaling pathway_Homo sapiens_hsa041500.44145109
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42874720
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42663375
88ABC transporters_Homo sapiens_hsa020100.41377915
89Systemic lupus erythematosus_Homo sapiens_hsa053220.41133505
90Focal adhesion_Homo sapiens_hsa045100.38947848
91ErbB signaling pathway_Homo sapiens_hsa040120.37427343
92HIF-1 signaling pathway_Homo sapiens_hsa040660.37248131
93Colorectal cancer_Homo sapiens_hsa052100.36956337
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36723752
95Inositol phosphate metabolism_Homo sapiens_hsa005620.36530767
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35816948
97Adherens junction_Homo sapiens_hsa045200.34309057
98Renal cell carcinoma_Homo sapiens_hsa052110.33202344
99Type II diabetes mellitus_Homo sapiens_hsa049300.32683942
100Endometrial cancer_Homo sapiens_hsa052130.32594911
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.32324277
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.31470263
103* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28671205
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28341099
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28147354
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27738053
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.26791781
108Insulin signaling pathway_Homo sapiens_hsa049100.26208231
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26170185
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24555777
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.23999029
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23428707
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23208619
114Linoleic acid metabolism_Homo sapiens_hsa005910.22845695
115Phagosome_Homo sapiens_hsa041450.21763375
116Glycerolipid metabolism_Homo sapiens_hsa005610.19650988

Most similar genes based on co-expression Upload to Enrichr

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