MAP3K19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)9.06513710
2left/right pattern formation (GO:0060972)7.95055721
3cilium movement (GO:0003341)7.01927759
4axoneme assembly (GO:0035082)6.88079104
5sensory perception of chemical stimulus (GO:0007606)6.04385847
6adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.79535200
7regulation of microtubule-based movement (GO:0060632)5.13375343
8axonemal dynein complex assembly (GO:0070286)5.08381775
9centriole assembly (GO:0098534)5.04948478
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.80732171
11cellular component assembly involved in morphogenesis (GO:0010927)4.79407921
12cellular potassium ion homeostasis (GO:0030007)4.78296540
13primary alcohol catabolic process (GO:0034310)4.76084072
14microtubule-based movement (GO:0007018)4.69901067
15protein localization to cilium (GO:0061512)4.68405179
16sperm capacitation (GO:0048240)4.54455903
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.43839683
18vitamin transmembrane transport (GO:0035461)4.35499783
19ventricular system development (GO:0021591)4.32288660
20negative regulation of inclusion body assembly (GO:0090084)4.29185244
21negative regulation of oligodendrocyte differentiation (GO:0048715)4.26283345
22epithelial cilium movement (GO:0003351)4.22613745
23cell projection assembly (GO:0030031)4.21861415
24ethanol metabolic process (GO:0006067)4.15828722
25sperm motility (GO:0030317)4.10365547
26lateral sprouting from an epithelium (GO:0060601)4.08134928
27regulation of chromatin binding (GO:0035561)4.06114932
28negative regulation of humoral immune response (GO:0002921)4.05410792
29diterpenoid biosynthetic process (GO:0016102)4.04728315
30one-carbon compound transport (GO:0019755)3.91464217
31sodium ion export (GO:0071436)3.91302334
32cilium or flagellum-dependent cell motility (GO:0001539)3.87982675
33lung epithelium development (GO:0060428)3.87846509
34regulation of interleukin-5 production (GO:0032674)3.84153973
35centriole replication (GO:0007099)3.80171674
36G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.80127126
37regulation of synapse structural plasticity (GO:0051823)3.79817587
38female mating behavior (GO:0060180)3.72222001
39lateral ventricle development (GO:0021670)3.71677522
40locomotory exploration behavior (GO:0035641)3.71569085
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.69453410
42establishment of tissue polarity (GO:0007164)3.61638749
43establishment of planar polarity (GO:0001736)3.61638749
44microtubule depolymerization (GO:0007019)3.60689538
45glomerular epithelial cell development (GO:0072310)3.56851481
46potassium ion homeostasis (GO:0055075)3.56493915
47calcium-mediated signaling using intracellular calcium source (GO:0035584)3.56448486
48cilium morphogenesis (GO:0060271)3.52737244
49regulation of short-term neuronal synaptic plasticity (GO:0048172)3.52308907
50tolerance induction (GO:0002507)3.51965003
51central nervous system myelination (GO:0022010)3.51377860
52axon ensheathment in central nervous system (GO:0032291)3.51377860
53determination of left/right symmetry (GO:0007368)3.49979706
54smoothened signaling pathway (GO:0007224)3.48020152
55regulation of female receptivity (GO:0045924)3.46273374
56glutamate secretion (GO:0014047)3.43190485
57intra-S DNA damage checkpoint (GO:0031573)3.39597892
58pyrimidine-containing compound transmembrane transport (GO:0072531)3.39328644
59potassium ion import (GO:0010107)3.38665612
60retinal rod cell development (GO:0046548)3.38417266
61response to xenobiotic stimulus (GO:0009410)3.37115999
62microtubule polymerization or depolymerization (GO:0031109)3.36591952
63regulation of cilium movement (GO:0003352)3.36574559
64auditory receptor cell differentiation (GO:0042491)3.36076797
65determination of bilateral symmetry (GO:0009855)3.33810497
66nucleoside diphosphate phosphorylation (GO:0006165)3.29714624
67specification of symmetry (GO:0009799)3.26975562
68negative regulation of T cell differentiation in thymus (GO:0033085)3.25196296
69neuron cell-cell adhesion (GO:0007158)3.22933817
70negative regulation of cytosolic calcium ion concentration (GO:0051481)3.22924005
71dopamine receptor signaling pathway (GO:0007212)3.22062898
72negative regulation of B cell mediated immunity (GO:0002713)3.20729533
73negative regulation of immunoglobulin mediated immune response (GO:0002890)3.20729533
74regulation of synaptic vesicle exocytosis (GO:2000300)3.19619023
75gamma-aminobutyric acid transport (GO:0015812)3.16419942
76intraciliary transport (GO:0042073)3.15539942
77establishment of apical/basal cell polarity (GO:0035089)3.13277228
78ethanol oxidation (GO:0006069)3.12037418
79nonmotile primary cilium assembly (GO:0035058)3.12032544
80behavioral response to cocaine (GO:0048148)3.11987782
81microtubule bundle formation (GO:0001578)3.10363155
82brain morphogenesis (GO:0048854)3.07135722
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06746050
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.02029283
85regulation of interleukin-13 production (GO:0032656)3.01354258
86synaptic vesicle maturation (GO:0016188)3.00882255
87neurotransmitter uptake (GO:0001504)2.97476602
88positive regulation of smoothened signaling pathway (GO:0045880)2.94941636
89membrane depolarization during action potential (GO:0086010)2.93926963
90cytoplasmic microtubule organization (GO:0031122)2.92611108
91cilium organization (GO:0044782)2.90420529
92cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90171253
93retinal cone cell development (GO:0046549)2.90132025
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89935519
95negative regulation of complement activation (GO:0045916)2.89626913
96L-amino acid import (GO:0043092)2.89083318
97response to auditory stimulus (GO:0010996)2.88843141
98regulation of glutamate receptor signaling pathway (GO:1900449)2.88178552
99dendrite morphogenesis (GO:0048813)2.87632338
100synaptic vesicle exocytosis (GO:0016079)2.87463585
101natural killer cell mediated immunity (GO:0002228)2.86626896
102natural killer cell mediated cytotoxicity (GO:0042267)2.86626896
103cilium assembly (GO:0042384)2.86298011
104neurotransmitter-gated ion channel clustering (GO:0072578)2.83717975
105sensory perception of taste (GO:0050909)2.83002584
106establishment of nucleus localization (GO:0040023)2.82763952
107activation of protein kinase A activity (GO:0034199)2.81818111
108regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.81068485
109regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.81027551
110regulation of NFAT protein import into nucleus (GO:0051532)2.80465541
111retinoic acid metabolic process (GO:0042573)2.80249753
112negative regulation of sodium ion transport (GO:0010766)2.78251356
113apical protein localization (GO:0045176)2.77884583
114regulation of synaptic vesicle transport (GO:1902803)2.75539208
115asymmetric protein localization (GO:0008105)2.75469948
116striatum development (GO:0021756)2.75259063
117long-term synaptic potentiation (GO:0060291)2.75072120
118regulation of beta-amyloid formation (GO:1902003)2.74478181
119terpenoid biosynthetic process (GO:0016114)2.74425983
120regulation of germinal center formation (GO:0002634)2.72203471
121regulation of inclusion body assembly (GO:0090083)2.71742448
122cell communication by electrical coupling (GO:0010644)2.71683045
123microtubule-based process (GO:0007017)2.71643028
124positive regulation of tolerance induction (GO:0002645)2.71341557
125microtubule severing (GO:0051013)2.69652339
126protein insertion into membrane (GO:0051205)2.68436892
127atrial cardiac muscle cell action potential (GO:0086014)2.68097570
128protein refolding (GO:0042026)2.68065110
129ovulation cycle (GO:0042698)2.67914056
130motile cilium assembly (GO:0044458)2.67559932
131O-glycan processing (GO:0016266)2.66998373
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.66244220
133establishment of monopolar cell polarity (GO:0061162)2.66244220
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.63265141
135limb development (GO:0060173)2.62679684
136appendage development (GO:0048736)2.62679684
137cellular sodium ion homeostasis (GO:0006883)2.60437378
138organelle assembly (GO:0070925)2.60223252
139left/right axis specification (GO:0070986)2.58491628
140GTP biosynthetic process (GO:0006183)2.58018230
141exogenous drug catabolic process (GO:0042738)2.57939955
142vocalization behavior (GO:0071625)2.56880433
143regulation of sodium ion transmembrane transporter activity (GO:2000649)2.56497038
144negative regulation of astrocyte differentiation (GO:0048712)2.56010194
145response to monoamine (GO:0071867)2.55578257
146response to catecholamine (GO:0071869)2.55578257
147positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.54267126
148regulation of neurotransmitter secretion (GO:0046928)2.54198052
149regulation of sodium ion transmembrane transport (GO:1902305)2.53968222
150chemical homeostasis within a tissue (GO:0048875)2.53917868
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53305531
152cerebellar granule cell differentiation (GO:0021707)2.53133305
153layer formation in cerebral cortex (GO:0021819)2.52496632
154negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49811357
155activation of adenylate cyclase activity (GO:0007190)2.49784263
156regulation of smoothened signaling pathway (GO:0008589)2.49600867
157photoreceptor cell maintenance (GO:0045494)2.49397810
158neurotransmitter secretion (GO:0007269)2.48937764
159synaptic vesicle endocytosis (GO:0048488)2.48650656
160positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47876981
161dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47389141
162regulation of oligodendrocyte differentiation (GO:0048713)2.46654632
163glutamate receptor signaling pathway (GO:0007215)2.46174686
164cellular response to monoamine stimulus (GO:0071868)2.45564711
165cellular response to catecholamine stimulus (GO:0071870)2.45564711
166heart looping (GO:0001947)2.44928331
167relaxation of cardiac muscle (GO:0055119)2.44675611
168neuronal stem cell maintenance (GO:0097150)2.44455810
169cellular response to glucagon stimulus (GO:0071377)2.43560681
170proline transport (GO:0015824)2.43194534
171metanephric mesenchyme development (GO:0072075)2.41986759
172embryonic heart tube morphogenesis (GO:0003143)2.40418572
173hypotonic response (GO:0006971)2.39502566
174regulation of cardioblast proliferation (GO:0003264)2.38684462
175regulation of secondary heart field cardioblast proliferation (GO:0003266)2.38684462
176protein polyglutamylation (GO:0018095)2.32716872
177embryonic camera-type eye development (GO:0031076)2.29494761
178photoreceptor cell differentiation (GO:0046530)2.28193564
179eye photoreceptor cell differentiation (GO:0001754)2.28193564
180urinary tract smooth muscle contraction (GO:0014848)2.28103675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.93732506
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.25233516
3DROSHA_22980978_ChIP-Seq_HELA_Human2.77058395
4IKZF1_21737484_ChIP-ChIP_HCT116_Human2.72333289
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.57317086
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38343314
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.16751240
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13649194
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13649194
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11140851
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11084608
12GBX2_23144817_ChIP-Seq_PC3_Human2.10787158
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10566550
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06302142
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01965450
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96259238
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88662464
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87089043
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.82688367
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79055724
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.75956694
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75170295
23REST_21632747_ChIP-Seq_MESCs_Mouse1.73037984
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.71221242
25FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69917270
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69186614
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68838433
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65533045
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64865868
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.62653782
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61648823
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59237096
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57776715
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.55148547
35TAF15_26573619_Chip-Seq_HEK293_Human1.53781434
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53277378
37FUS_26573619_Chip-Seq_HEK293_Human1.53177130
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46707444
39AR_21572438_ChIP-Seq_LNCaP_Human1.43940427
40SMAD4_21799915_ChIP-Seq_A2780_Human1.43631833
41AHR_22903824_ChIP-Seq_MCF-7_Human1.39105990
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38594100
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.37628139
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36187140
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36014695
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32785368
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31360411
48TP63_23658742_ChIP-Seq_EP156T_Human1.31279316
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.29706161
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28153028
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27872215
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26462928
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25800177
54P300_19829295_ChIP-Seq_ESCs_Human1.25099521
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.24509464
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.24370386
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23927601
58STAT3_23295773_ChIP-Seq_U87_Human1.23131533
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.22867652
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20851252
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20851252
62SMRT_27268052_Chip-Seq_Bcells_Human1.20540170
63PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.20044083
64TP53_16413492_ChIP-PET_HCT116_Human1.19851099
65ETV1_20927104_ChIP-Seq_GIST48_Human1.19029116
66VDR_22108803_ChIP-Seq_LS180_Human1.18930138
67TCF4_22108803_ChIP-Seq_LS180_Human1.18456478
68PHF8_20622853_ChIP-Seq_HELA_Human1.17878549
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.17154069
70BCAT_22108803_ChIP-Seq_LS180_Human1.16831033
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16321933
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16085489
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16061102
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.15775164
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15507835
76RXR_22108803_ChIP-Seq_LS180_Human1.14808545
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14516378
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12378813
79CBP_20019798_ChIP-Seq_JUKART_Human1.12378813
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12287663
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12029388
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11689417
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11617280
84HNFA_21074721_ChIP-Seq_CACO-2_Human1.10658341
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10214954
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10085608
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09831481
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.09429500
89TBL1_22424771_ChIP-Seq_293T_Human1.08159657
90KLF5_25053715_ChIP-Seq_YYC3_Human1.08097328
91AR_19668381_ChIP-Seq_PC3_Human1.07931391
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07353330
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07225635
94SMC4_20622854_ChIP-Seq_HELA_Human1.07139946
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.07102203
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06894193
97SMAD3_21741376_ChIP-Seq_HESCs_Human1.06409901
98ER_23166858_ChIP-Seq_MCF-7_Human1.06300008
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06099854
100AR_25329375_ChIP-Seq_VCAP_Human1.05225342
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04707986
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.04296779
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03912467
104KDM2B_26808549_Chip-Seq_K562_Human1.03601956
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03576537
106NFYA_21822215_ChIP-Seq_K562_Human1.03172614
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02998817
108FOXA1_25552417_ChIP-Seq_VCAP_Human1.02564821
109TP53_18474530_ChIP-ChIP_U2OS_Human1.02489169
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02139363
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01639253
112TCF4_23295773_ChIP-Seq_U87_Human1.01565831
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99126314
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99067442
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.98811823
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98534813
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98471113
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.98398033
119RBPJ_21746931_ChIP-Seq_IB4_Human0.97675237
120CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97209939
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.97085069
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.97002118
123TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96939994
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96605837
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96475357
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96373627
127NFYB_21822215_ChIP-Seq_K562_Human0.96286482
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96064370
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.96015203
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95720547
131RUNX2_22187159_ChIP-Seq_PCA_Human0.95462801
132RUNX_20019798_ChIP-Seq_JUKART_Human0.95406717
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94126789
134CDX2_22108803_ChIP-Seq_LS180_Human0.93672582
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93146215
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.92961382
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92634018
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92543297
139GATA4_25053715_ChIP-Seq_YYC3_Human0.92308252
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91428348
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90816949
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86605997
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85356642
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.84148443
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82942893
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82892505
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82752682
148LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81795962
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81598678
150GATA1_26923725_Chip-Seq_HPCs_Mouse0.81402717
151POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80494700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction7.71346644
2MP0008875_abnormal_xenobiotic_pharmacok4.34489567
3MP0005499_abnormal_olfactory_system4.20641335
4MP0005394_taste/olfaction_phenotype4.20641335
5MP0002132_abnormal_respiratory_system4.06053654
6MP0004859_abnormal_synaptic_plasticity3.94740317
7MP0008789_abnormal_olfactory_epithelium3.86144894
8MP0005645_abnormal_hypothalamus_physiol3.67337738
9MP0002277_abnormal_respiratory_mucosa3.22329772
10MP0003878_abnormal_ear_physiology3.10843356
11MP0005377_hearing/vestibular/ear_phenot3.10843356
12MP0002282_abnormal_trachea_morphology3.07852094
13MP0004133_heterotaxia2.89893416
14MP0004270_analgesia2.86485556
15MP0004043_abnormal_pH_regulation2.79883879
16MP0004858_abnormal_nervous_system2.76134050
17MP0000383_abnormal_hair_follicle2.67156595
18MP0003635_abnormal_synaptic_transmissio2.61954427
19MP0005423_abnormal_somatic_nervous2.61657036
20MP0003183_abnormal_peptide_metabolism2.56885003
21MP0000372_irregular_coat_pigmentation2.48396516
22MP0009780_abnormal_chondrocyte_physiolo2.42734504
23MP0000566_synostosis2.34963189
24MP0003880_abnormal_central_pattern2.28680243
25MP0002064_seizures2.27545440
26MP0002734_abnormal_mechanical_nocicepti2.24259910
27MP0002063_abnormal_learning/memory/cond2.22371568
28MP0002909_abnormal_adrenal_gland2.15612195
29MP0009745_abnormal_behavioral_response2.14346701
30MP0002272_abnormal_nervous_system2.11625059
31MP0001486_abnormal_startle_reflex2.01245952
32MP0009046_muscle_twitch1.96569663
33MP0002249_abnormal_larynx_morphology1.92591868
34MP0010678_abnormal_skin_adnexa1.90035916
35MP0002572_abnormal_emotion/affect_behav1.81158960
36MP0005083_abnormal_biliary_tract1.80918105
37MP0000778_abnormal_nervous_system1.77624340
38MP0002653_abnormal_ependyma_morphology1.74630846
39MP0005174_abnormal_tail_pigmentation1.74490264
40MP0002557_abnormal_social/conspecific_i1.73242535
41MP0001485_abnormal_pinna_reflex1.60711594
42MP0005503_abnormal_tendon_morphology1.59810547
43MP0001440_abnormal_grooming_behavior1.54409249
44MP0002184_abnormal_innervation1.53683898
45MP0002067_abnormal_sensory_capabilities1.50710751
46MP0000026_abnormal_inner_ear1.50206936
47MP0005171_absent_coat_pigmentation1.49309968
48MP0005646_abnormal_pituitary_gland1.43907107
49MP0008569_lethality_at_weaning1.43565445
50MP0003690_abnormal_glial_cell1.39590611
51MP0003303_peritoneal_inflammation1.39352640
52MP0006276_abnormal_autonomic_nervous1.38609398
53MP0004019_abnormal_vitamin_homeostasis1.35987301
54MP0005623_abnormal_meninges_morphology1.34736935
55MP0001765_abnormal_ion_homeostasis1.32607941
56MP0001501_abnormal_sleep_pattern1.32361656
57MP0001968_abnormal_touch/_nociception1.31959802
58MP0003634_abnormal_glial_cell1.31096508
59MP0003633_abnormal_nervous_system1.30900605
60MP0002882_abnormal_neuron_morphology1.25654115
61MP0001542_abnormal_bone_strength1.22335014
62MP0002160_abnormal_reproductive_system1.17129053
63MP0005410_abnormal_fertilization1.16527486
64MP0002876_abnormal_thyroid_physiology1.14331567
65MP0001970_abnormal_pain_threshold1.13658109
66MP0002638_abnormal_pupillary_reflex1.13442997
67MP0003136_yellow_coat_color1.13420823
68MP0005387_immune_system_phenotype1.12814976
69MP0001790_abnormal_immune_system1.12814976
70MP0003879_abnormal_hair_cell1.10875107
71MP0008874_decreased_physiological_sensi1.08696076
72MP0002152_abnormal_brain_morphology1.08303974
73MP0001293_anophthalmia1.07000285
74MP0003698_abnormal_male_reproductive1.06186405
75MP0005310_abnormal_salivary_gland1.05186794
76MP0001346_abnormal_lacrimal_gland1.04100020
77MP0002254_reproductive_system_inflammat1.02532645
78MP0002938_white_spotting1.02347290
79MP0003329_amyloid_beta_deposits0.99066141
80MP0001502_abnormal_circadian_rhythm0.98191064
81MP0002736_abnormal_nociception_after0.97909681
82MP0001929_abnormal_gametogenesis0.97647232
83MP0004885_abnormal_endolymph0.96515557
84MP0002233_abnormal_nose_morphology0.94840158
85MP0005253_abnormal_eye_physiology0.94176008
86MP0003631_nervous_system_phenotype0.93342755
87MP0000003_abnormal_adipose_tissue0.92979356
88MP0004811_abnormal_neuron_physiology0.92369807
89MP0002733_abnormal_thermal_nociception0.91778927
90MP0000955_abnormal_spinal_cord0.91492883
91MP0002066_abnormal_motor_capabilities/c0.89453096
92MP0002229_neurodegeneration0.89292427
93MP0005551_abnormal_eye_electrophysiolog0.88026931
94MP0000049_abnormal_middle_ear0.87218545
95MP0010030_abnormal_orbit_morphology0.87130475
96MP0002752_abnormal_somatic_nervous0.84915455
97MP0005636_abnormal_mineral_homeostasis0.84123069
98MP0005391_vision/eye_phenotype0.83911045
99MP0009384_cardiac_valve_regurgitation0.83801785
100MP0001800_abnormal_humoral_immune0.82704054
101MP0004142_abnormal_muscle_tone0.82502925
102MP0000569_abnormal_digit_pigmentation0.80806304
103MP0001286_abnormal_eye_development0.80381226
104MP0003300_gastrointestinal_ulcer0.80378054
105MP0005084_abnormal_gallbladder_morpholo0.80228274
106MP0002139_abnormal_hepatobiliary_system0.79021971
107MP0001963_abnormal_hearing_physiology0.78434061
108MP0000631_abnormal_neuroendocrine_gland0.77743180
109MP0000920_abnormal_myelination0.77189668
110MP0001835_abnormal_antigen_presentation0.76840240
111MP0000604_amyloidosis0.76761008
112MP0003937_abnormal_limbs/digits/tail_de0.76724051
113MP0005388_respiratory_system_phenotype0.75975869
114MP0002133_abnormal_respiratory_system0.75975869
115MP0004742_abnormal_vestibular_system0.75965032
116MP0002822_catalepsy0.74929331
117MP0001324_abnormal_eye_pigmentation0.74718795
118MP0003283_abnormal_digestive_organ0.74523441
119MP0003656_abnormal_erythrocyte_physiolo0.74359852
120MP0001270_distended_abdomen0.73770781
121MP0003045_fibrosis0.73583647
122MP0000467_abnormal_esophagus_morphology0.73468739
123MP0005395_other_phenotype0.73297089
124MP0002116_abnormal_craniofacial_bone0.73234873
125MP0005195_abnormal_posterior_eye0.73103011
126MP0003763_abnormal_thymus_physiology0.72944274
127MP0002928_abnormal_bile_duct0.72673087
128MP0000534_abnormal_ureter_morphology0.72025664
129MP0005165_increased_susceptibility_to0.71371153
130MP0004924_abnormal_behavior0.69643766
131MP0005386_behavior/neurological_phenoty0.69643766
132MP0002092_abnormal_eye_morphology0.69388280
133MP0003943_abnormal_hepatobiliary_system0.69165354
134MP0003861_abnormal_nervous_system0.68886403
135MP0002095_abnormal_skin_pigmentation0.68536757
136MP0003942_abnormal_urinary_system0.66608228
137MP0003787_abnormal_imprinting0.65944694
138MP0001879_abnormal_lymphatic_vessel0.63934410
139MP0003075_altered_response_to0.63827117
140MP0001905_abnormal_dopamine_level0.63707972
141MP0005365_abnormal_bile_salt0.62917221
142MP0002896_abnormal_bone_mineralization0.62141768
143MP0005389_reproductive_system_phenotype0.58423898
144MP0001944_abnormal_pancreas_morphology0.58337497
145MP0001849_ear_inflammation0.57772134
146MP0005167_abnormal_blood-brain_barrier0.57377318
147MP0000685_abnormal_immune_system0.57334407
148MP0000762_abnormal_tongue_morphology0.56595456
149MP0005248_abnormal_Harderian_gland0.56335915
150MP0002735_abnormal_chemical_nociception0.55434928
151MP0004085_abnormal_heartbeat0.55415740
152MP0000678_abnormal_parathyroid_gland0.55240232
153MP0002136_abnormal_kidney_physiology0.54826249
154MP0001299_abnormal_eye_distance/0.54782083
155MP0005164_abnormal_response_to0.53829695
156MP0001943_abnormal_respiration0.53301180
157MP0004130_abnormal_muscle_cell0.52131506
158MP0004510_myositis0.52128059
159MP0002168_other_aberrant_phenotype0.51617782
160MP0003938_abnormal_ear_development0.51122782
161MP0002161_abnormal_fertility/fecundity0.49647955
162MP0003890_abnormal_embryonic-extraembry0.49476525

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.04376502
2Abnormal respiratory motile cilium physiology (HP:0012261)8.89267283
3Rhinitis (HP:0012384)8.08007814
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.40808599
5Abnormal respiratory epithelium morphology (HP:0012253)6.83331119
6Abnormal respiratory motile cilium morphology (HP:0005938)6.83331119
7Bronchiectasis (HP:0002110)4.84870728
8Recurrent sinusitis (HP:0011108)4.70099762
9Chronic sinusitis (HP:0011109)4.17706831
10Atonic seizures (HP:0010819)4.12100649
11Hypothermia (HP:0002045)4.11351274
12Chronic bronchitis (HP:0004469)4.04913864
13Febrile seizures (HP:0002373)3.91503546
14Pancreatic fibrosis (HP:0100732)3.76174680
15Infertility (HP:0000789)3.70023606
16Gait imbalance (HP:0002141)3.68266293
17Congenital primary aphakia (HP:0007707)3.54643288
18Abnormality of midbrain morphology (HP:0002418)3.40894853
19Molar tooth sign on MRI (HP:0002419)3.40894853
20Focal seizures (HP:0007359)3.35500719
21Absence seizures (HP:0002121)3.34051272
22Medial flaring of the eyebrow (HP:0010747)3.25875156
23Nephrogenic diabetes insipidus (HP:0009806)3.17114595
24Dialeptic seizures (HP:0011146)3.07501292
25Recurrent otitis media (HP:0000403)2.97948481
26Absent/shortened dynein arms (HP:0200106)2.96071431
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.96071431
28Bronchitis (HP:0012387)2.94538130
29Male infertility (HP:0003251)2.92932786
30Retinal dysplasia (HP:0007973)2.85021104
31Visual hallucinations (HP:0002367)2.84507539
32Bifid tongue (HP:0010297)2.82676247
33Genital tract atresia (HP:0001827)2.77763381
34Vaginal atresia (HP:0000148)2.75553084
35True hermaphroditism (HP:0010459)2.67588230
36Focal motor seizures (HP:0011153)2.66134031
37Nasal polyposis (HP:0100582)2.65466336
38Limb dystonia (HP:0002451)2.58163463
39Xerostomia (HP:0000217)2.54594887
40Supranuclear gaze palsy (HP:0000605)2.53017617
41Poor coordination (HP:0002370)2.52036407
42Agammaglobulinemia (HP:0004432)2.51924505
43Megalencephaly (HP:0001355)2.50165810
44Nephronophthisis (HP:0000090)2.47325112
45Tubular atrophy (HP:0000092)2.44421226
46Atelectasis (HP:0100750)2.44269103
47Chronic hepatic failure (HP:0100626)2.38605627
48Generalized tonic-clonic seizures (HP:0002069)2.37849457
49Hyperactive renin-angiotensin system (HP:0000841)2.32524302
50Gastrointestinal stroma tumor (HP:0100723)2.30239674
51Cystic liver disease (HP:0006706)2.25710505
52Recurrent bronchitis (HP:0002837)2.20954308
53Abnormality of dentin (HP:0010299)2.18853116
54Postaxial hand polydactyly (HP:0001162)2.16440007
55Papilledema (HP:0001085)2.15764268
56Abnormality of binocular vision (HP:0011514)2.10700652
57Diplopia (HP:0000651)2.10700652
58Hemiplegia (HP:0002301)2.10101448
59Anencephaly (HP:0002323)2.10035467
60Abnormality of the nasal mucosa (HP:0000433)2.06092347
61Bell-shaped thorax (HP:0001591)2.04287421
62Aplasia/Hypoplasia of the lens (HP:0008063)2.03156722
63Myokymia (HP:0002411)2.03101057
64Abnormality of macular pigmentation (HP:0008002)1.98163908
65Pancreatic cysts (HP:0001737)1.97560439
66Abnormality of the renal medulla (HP:0100957)1.97312187
67Truncal ataxia (HP:0002078)1.96977911
68Sclerocornea (HP:0000647)1.96910352
69Anosmia (HP:0000458)1.94151177
70Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93922143
71Abnormal biliary tract physiology (HP:0012439)1.93584710
72Bile duct proliferation (HP:0001408)1.93584710
73Split foot (HP:0001839)1.92662763
74Bradycardia (HP:0001662)1.90047498
75Male pseudohermaphroditism (HP:0000037)1.88992027
76Tubulointerstitial abnormality (HP:0001969)1.88188868
77Epileptic encephalopathy (HP:0200134)1.87279294
78Specific learning disability (HP:0001328)1.83758032
79Median cleft lip (HP:0000161)1.83746232
80Neoplasm of head and neck (HP:0012288)1.80846763
81Esophageal neoplasm (HP:0100751)1.80846763
82Oculomotor apraxia (HP:0000657)1.80501123
83Congenital hepatic fibrosis (HP:0002612)1.80471334
84Occipital encephalocele (HP:0002085)1.78409445
85Short nail (HP:0001799)1.77436825
86Furrowed tongue (HP:0000221)1.72589245
87Aplasia involving bones of the upper limbs (HP:0009823)1.71082833
88Aplasia of the phalanges of the hand (HP:0009802)1.71082833
89Aplasia involving bones of the extremities (HP:0009825)1.71082833
90Palpitations (HP:0001962)1.70347974
91Verrucae (HP:0200043)1.66491616
92Papilloma (HP:0012740)1.66491616
93Progressive cerebellar ataxia (HP:0002073)1.65982916
94Vertebral arch anomaly (HP:0008438)1.65679381
95Hyperventilation (HP:0002883)1.64316444
96Chronic otitis media (HP:0000389)1.63634154
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.63017842
98Action tremor (HP:0002345)1.62285837
99Decreased circulating renin level (HP:0003351)1.61323519
100Hemiparesis (HP:0001269)1.61064303
101Stage 5 chronic kidney disease (HP:0003774)1.60244851
102Hyperkalemia (HP:0002153)1.59574695
103Bony spicule pigmentary retinopathy (HP:0007737)1.58908367
104Postural instability (HP:0002172)1.58876488
105Left ventricular hypertrophy (HP:0001712)1.58171020
106Postaxial foot polydactyly (HP:0001830)1.57924475
107Humeroradial synostosis (HP:0003041)1.57804283
108Synostosis involving the elbow (HP:0003938)1.57804283
109Widely spaced teeth (HP:0000687)1.57277913
110Nephropathy (HP:0000112)1.55898584
111Colitis (HP:0002583)1.55050014
112Polydipsia (HP:0001959)1.54862554
113Abnormal drinking behavior (HP:0030082)1.54862554
114Hypotelorism (HP:0000601)1.54443054
115Abnormal rod and cone electroretinograms (HP:0008323)1.51033176
116Adactyly (HP:0009776)1.50851282
117Absent frontal sinuses (HP:0002688)1.50308288
118Tubulointerstitial nephritis (HP:0001970)1.49771327
119Broad foot (HP:0001769)1.49642906
120Abnormality of the dental pulp (HP:0006479)1.49092446
121Anophthalmia (HP:0000528)1.39186047
122Preaxial hand polydactyly (HP:0001177)1.36557903
123Renal salt wasting (HP:0000127)1.32878476
124Abnormality of the renal cortex (HP:0011035)1.29920039
125Asplenia (HP:0001746)1.29612015
126Abnormality of the dental root (HP:0006486)1.27281672
127Taurodontia (HP:0000679)1.27281672
128Abnormality of permanent molar morphology (HP:0011071)1.27281672
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.24873073
130Broad distal phalanx of finger (HP:0009836)1.21300776
131Cone-rod dystrophy (HP:0000548)1.20935841
132Bifid scrotum (HP:0000048)1.19939146
133Tubulointerstitial fibrosis (HP:0005576)1.19710005
134Hyperaldosteronism (HP:0000859)1.19003148
135Abnormality of molar (HP:0011077)1.17687891
136Abnormality of molar morphology (HP:0011070)1.17687891
137Supernumerary spleens (HP:0009799)1.17416435
138Optic nerve coloboma (HP:0000588)1.12622730
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.10401775
140Abnormality of renin-angiotensin system (HP:0000847)1.08244369
141Narrow forehead (HP:0000341)1.05211915
142Short thorax (HP:0010306)1.03948877
143Holoprosencephaly (HP:0001360)1.02278142
144Decreased central vision (HP:0007663)1.02153506
145Portal hypertension (HP:0001409)1.02105521
146Abnormality of chloride homeostasis (HP:0011422)1.01896353
147Retinitis pigmentosa (HP:0000510)1.00585491
148Prominent nasal bridge (HP:0000426)1.00200323
149Intellectual disability, moderate (HP:0002342)0.98823344
150Recurrent pneumonia (HP:0006532)0.98422443
151Renal dysplasia (HP:0000110)0.98148809
152Short ribs (HP:0000773)0.96267604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.86803898
2CAMKK23.36633477
3MAP3K103.30575181
4ERBB33.22752675
5STK243.22532475
6CAMK1D3.14338528
7CAMK1G3.11707248
8PRPF4B2.62910981
9EPHA22.60650395
10NTRK22.59874518
11TNIK2.11347042
12BMPR22.10174154
13TSSK62.01225555
14PHKG21.99904143
15PHKG11.99904143
16WEE11.92245863
17DAPK21.90844750
18MAP4K11.82955296
19STK38L1.80302540
20CAMKK11.77982989
21PTK2B1.74474055
22MARK11.61260822
23WNK41.60569211
24SGK21.59292723
25NTRK31.58434659
26VRK11.52615843
27MAPKAPK31.52414627
28EEF2K1.44565974
29GRK61.42224931
30EPHA41.40365493
31SGK31.32605856
32STK391.27458157
33MAPK131.24354003
34MINK11.17959914
35SGK2231.17784847
36SGK4941.17784847
37FGFR31.16111645
38KIT1.15741232
39RIPK11.11946246
40PNCK1.11734816
41CSF1R1.06139660
42ARAF1.04615915
43HIPK21.03456388
44MST41.02818918
45MAP3K41.02631462
46FLT30.99788691
47PAK30.99347422
48SIK20.95067710
49FES0.94202692
50MAP3K130.93441688
51LMTK20.90608227
52PRKCH0.90203648
53NLK0.89791595
54CDK30.88103918
55JAK10.87010916
56MAP2K70.86554604
57CDK50.84489790
58NEK60.83711513
59AKT30.79936968
60LATS10.79556103
61CAMK2B0.79531335
62MAP3K90.77440471
63MAP3K70.76336077
64DYRK1A0.75784115
65CDK120.75343737
66MET0.74392684
67NME10.74039408
68FGR0.73828074
69CAMK40.73315951
70BRSK20.71942173
71MAPK120.71460173
72RIPK40.71385323
73EPHA30.71063091
74WNK10.70623208
75EPHB10.70427397
76TLK10.67397062
77PRKCQ0.67163241
78BCR0.66828895
79MST1R0.66804097
80ROCK20.66665441
81PLK20.65049623
82SIK10.63789459
83BMPR1B0.63391672
84CAMK10.61545300
85CSNK1G20.59815005
86SYK0.58703729
87INSRR0.57555582
88ERBB20.57431554
89MAP3K20.56891517
90IKBKE0.56858859
91CDC42BPA0.55367243
92MAP3K30.54229679
93PASK0.54165729
94TNK20.54158874
95TTK0.53983331
96FYN0.53334847
97MAP3K120.52086914
98STK110.51895384
99CAMK2D0.51627916
100STK160.51504276
101TRPM70.51481350
102HCK0.51366522
103RPS6KA20.50638570
104CSNK1A1L0.50445578
105PRKCG0.49629501
106MAP2K20.49423479
107MKNK20.49308316
108IRAK10.49027563
109PKN10.48631794
110STK380.48472572
111GRK50.47655893
112PRKD20.47485570
113NTRK10.47376748
114SRPK10.45278424
115STK100.45127620
116PAK60.44339911
117FRK0.44127131
118CAMK2A0.44066698
119CASK0.43008864
120MARK20.42953192
121FGFR20.42706875
122ADRBK20.42195630
123NEK90.40249842
124LRRK20.40150524
125PRKCI0.39943331
126UHMK10.39849609
127BRAF0.38484040
128MUSK0.38441895
129SIK30.38084287
130CSK0.37480578
131CSNK1G30.36169228
132DAPK10.35163984
133PRKCZ0.34641727
134CSNK1G10.34610472
135MAPK70.34070465
136TGFBR10.34053894
137PRKAA20.33856209
138CDK80.33570015
139PRKD10.33288662
140SGK10.32539242
141MAP2K40.32043826
142STK30.31213329
143ROCK10.25281368
144ADRBK10.23856678
145ACVR1B0.23282607
146PRKCD0.20889493
147RET0.20503407
148MAPK100.20410642
149PRKCE0.20166027
150AURKA0.18332806
151PDPK10.18139970
152TYK20.17587295
153MAPKAPK50.17487618
154ABL10.17144809
155TBK10.16713709
156DYRK1B0.16704071
157PAK20.16378722
158PRKD30.15104336
159PRKACA0.13640725
160CDK90.12964183
161PRKCA0.10945045
162GRK10.10932427
163PRKG10.10759493
164TRIB30.10541073
165CAMK2G0.10291512
166GSK3A0.10163692

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.41376708
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.71463234
3Chemical carcinogenesis_Homo sapiens_hsa052043.97170768
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.90813326
5Histidine metabolism_Homo sapiens_hsa003403.75708806
6Phenylalanine metabolism_Homo sapiens_hsa003603.75538839
7Huntingtons disease_Homo sapiens_hsa050162.87452601
8Tyrosine metabolism_Homo sapiens_hsa003502.85168044
9Nitrogen metabolism_Homo sapiens_hsa009102.68581641
10beta-Alanine metabolism_Homo sapiens_hsa004102.40013533
11GABAergic synapse_Homo sapiens_hsa047272.35950384
12Circadian entrainment_Homo sapiens_hsa047132.32919623
13Glutamatergic synapse_Homo sapiens_hsa047242.25314135
14Morphine addiction_Homo sapiens_hsa050322.19131679
15Caffeine metabolism_Homo sapiens_hsa002322.19004641
16Phototransduction_Homo sapiens_hsa047442.12715693
17Salivary secretion_Homo sapiens_hsa049702.07743519
18Retinol metabolism_Homo sapiens_hsa008302.06433121
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99953952
20Gastric acid secretion_Homo sapiens_hsa049711.98060362
21Taste transduction_Homo sapiens_hsa047421.88183168
22Insulin secretion_Homo sapiens_hsa049111.82861180
23Dopaminergic synapse_Homo sapiens_hsa047281.79360772
24Synaptic vesicle cycle_Homo sapiens_hsa047211.78848140
25Nicotine addiction_Homo sapiens_hsa050331.77248055
26Glutathione metabolism_Homo sapiens_hsa004801.76950533
27Long-term potentiation_Homo sapiens_hsa047201.73805594
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72471478
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69091610
30Linoleic acid metabolism_Homo sapiens_hsa005911.67953826
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64867169
32Cholinergic synapse_Homo sapiens_hsa047251.61187641
33Tight junction_Homo sapiens_hsa045301.59505360
34B cell receptor signaling pathway_Homo sapiens_hsa046621.52924789
35Amphetamine addiction_Homo sapiens_hsa050311.52395646
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.48806939
37Hedgehog signaling pathway_Homo sapiens_hsa043401.44563842
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.43178868
39cAMP signaling pathway_Homo sapiens_hsa040241.37741322
40Renin secretion_Homo sapiens_hsa049241.36331867
41Serotonergic synapse_Homo sapiens_hsa047261.35463623
42Basal cell carcinoma_Homo sapiens_hsa052171.34051616
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33927627
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27558395
45Calcium signaling pathway_Homo sapiens_hsa040201.25923586
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23936459
47GnRH signaling pathway_Homo sapiens_hsa049121.18960321
48Notch signaling pathway_Homo sapiens_hsa043301.17199584
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16481338
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14858504
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14485452
52Oxytocin signaling pathway_Homo sapiens_hsa049211.10155253
53Thyroid hormone synthesis_Homo sapiens_hsa049181.09231537
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05874595
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05666423
56Estrogen signaling pathway_Homo sapiens_hsa049151.04131707
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01929374
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.01852676
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00865233
60Dorso-ventral axis formation_Homo sapiens_hsa043201.00856331
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98260294
62Fatty acid degradation_Homo sapiens_hsa000710.96447940
63Melanogenesis_Homo sapiens_hsa049160.96348721
64Primary immunodeficiency_Homo sapiens_hsa053400.94546508
65Glioma_Homo sapiens_hsa052140.94405603
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.90448812
67Cocaine addiction_Homo sapiens_hsa050300.89720819
68Peroxisome_Homo sapiens_hsa041460.89379820
69Bile secretion_Homo sapiens_hsa049760.86197816
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85090382
71Long-term depression_Homo sapiens_hsa047300.84534643
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84139425
73Pancreatic secretion_Homo sapiens_hsa049720.84084467
74Fatty acid biosynthesis_Homo sapiens_hsa000610.83575055
75TGF-beta signaling pathway_Homo sapiens_hsa043500.83247187
76Hematopoietic cell lineage_Homo sapiens_hsa046400.81654142
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79829813
78Arachidonic acid metabolism_Homo sapiens_hsa005900.78564241
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78183320
80Alcoholism_Homo sapiens_hsa050340.77491028
81Gap junction_Homo sapiens_hsa045400.77279876
82Chemokine signaling pathway_Homo sapiens_hsa040620.77118063
83Starch and sucrose metabolism_Homo sapiens_hsa005000.75473861
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75169827
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72460279
86Vibrio cholerae infection_Homo sapiens_hsa051100.72429864
87Hippo signaling pathway_Homo sapiens_hsa043900.72236590
88Choline metabolism in cancer_Homo sapiens_hsa052310.67713425
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.66915109
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.66332028
91Type II diabetes mellitus_Homo sapiens_hsa049300.65921266
92PPAR signaling pathway_Homo sapiens_hsa033200.65733186
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.62435692
94Collecting duct acid secretion_Homo sapiens_hsa049660.60187355
95Inositol phosphate metabolism_Homo sapiens_hsa005620.58947096
96MAPK signaling pathway_Homo sapiens_hsa040100.58729960
97Ovarian steroidogenesis_Homo sapiens_hsa049130.58192884
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57432179
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56790069
100Ras signaling pathway_Homo sapiens_hsa040140.56490781
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.55566820
102Axon guidance_Homo sapiens_hsa043600.53763000
103Tryptophan metabolism_Homo sapiens_hsa003800.53180671
104Butanoate metabolism_Homo sapiens_hsa006500.52835037
105Antigen processing and presentation_Homo sapiens_hsa046120.52168670
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51709417
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50645862
108Glucagon signaling pathway_Homo sapiens_hsa049220.50581357
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49656858
110ErbB signaling pathway_Homo sapiens_hsa040120.49381819
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48659311
112Colorectal cancer_Homo sapiens_hsa052100.47392500
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47122559
114Rap1 signaling pathway_Homo sapiens_hsa040150.47106835
115Pancreatic cancer_Homo sapiens_hsa052120.44017855
116Tuberculosis_Homo sapiens_hsa051520.43925761
117ABC transporters_Homo sapiens_hsa020100.43844694
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41995609
119Adherens junction_Homo sapiens_hsa045200.41645458
120Dilated cardiomyopathy_Homo sapiens_hsa054140.41124606
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.39484841
122Complement and coagulation cascades_Homo sapiens_hsa046100.38624356
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37859437
124Insulin signaling pathway_Homo sapiens_hsa049100.37044931
125Wnt signaling pathway_Homo sapiens_hsa043100.36983815
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36530456
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.36121999
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35810628
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35694017
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35473418
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35170414
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.34861100
133Endometrial cancer_Homo sapiens_hsa052130.34318436
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33980428
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33098697
136Vitamin digestion and absorption_Homo sapiens_hsa049770.32821406
137Non-small cell lung cancer_Homo sapiens_hsa052230.32687479
138Mineral absorption_Homo sapiens_hsa049780.32278941
139Osteoclast differentiation_Homo sapiens_hsa043800.32238210
140Endocytosis_Homo sapiens_hsa041440.31671218
141Platelet activation_Homo sapiens_hsa046110.31253859
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31244546
143Prion diseases_Homo sapiens_hsa050200.30935473
144T cell receptor signaling pathway_Homo sapiens_hsa046600.30931758
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28509246
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28334740
147Hepatitis C_Homo sapiens_hsa051600.28028554
148Circadian rhythm_Homo sapiens_hsa047100.27488351
149ECM-receptor interaction_Homo sapiens_hsa045120.27285395
150Sphingolipid metabolism_Homo sapiens_hsa006000.26818008
151Systemic lupus erythematosus_Homo sapiens_hsa053220.23713306
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23497389
153Steroid biosynthesis_Homo sapiens_hsa001000.20598918
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19178442
155Prostate cancer_Homo sapiens_hsa052150.19148302
156NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18657553
157Metabolic pathways_Homo sapiens_hsa011000.17498524
158Glycerolipid metabolism_Homo sapiens_hsa005610.16683020
159Cardiac muscle contraction_Homo sapiens_hsa042600.16460876

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