MAP3K2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.61436537
2cellular extravasation (GO:0045123)4.60871692
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.49872560
4positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.41962601
5detection of external biotic stimulus (GO:0098581)4.29329806
6microglial cell activation (GO:0001774)4.14692426
7regulation of B cell receptor signaling pathway (GO:0050855)4.09970937
8detection of other organism (GO:0098543)4.03519883
9macrophage activation (GO:0042116)3.86670669
10neutrophil activation involved in immune response (GO:0002283)3.84623740
11neutrophil mediated immunity (GO:0002446)3.77810221
12detection of biotic stimulus (GO:0009595)3.74245463
13growth hormone receptor signaling pathway (GO:0060396)3.73734846
14response to peptidoglycan (GO:0032494)3.64872045
15positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.62783620
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.60763466
17response to host immune response (GO:0052572)3.53356263
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.53356263
19negative regulation of interleukin-12 production (GO:0032695)3.46301759
20production of molecular mediator involved in inflammatory response (GO:0002532)3.40635371
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.34854858
22response to host (GO:0075136)3.34854858
23response to host defenses (GO:0052200)3.34854858
24detection of bacterium (GO:0016045)3.34606846
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.25504315
26myeloid leukocyte mediated immunity (GO:0002444)3.23926265
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22696979
28negative regulation of cell killing (GO:0031342)3.22696979
29cellular response to growth hormone stimulus (GO:0071378)3.16899239
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.16734698
31neutrophil activation (GO:0042119)3.15943838
32regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.05717786
33B cell receptor signaling pathway (GO:0050853)3.05349015
34hepatocyte apoptotic process (GO:0097284)3.00119842
35positive regulation of mast cell activation (GO:0033005)2.99054953
36negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97385793
37negative regulation of T-helper cell differentiation (GO:0045623)2.97385793
38negative regulation of T cell mediated immunity (GO:0002710)2.94543017
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91849269
40response to interleukin-15 (GO:0070672)2.91700687
41T-helper 1 type immune response (GO:0042088)2.90827160
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89231414
43myeloid cell activation involved in immune response (GO:0002275)2.87657379
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84450197
45granulocyte activation (GO:0036230)2.82406392
46positive regulation of interferon-alpha production (GO:0032727)2.81277214
47positive regulation of gamma-delta T cell activation (GO:0046645)2.79968014
48positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75676245
49regulation of mast cell activation (GO:0033003)2.73540794
50negative regulation of immunoglobulin mediated immune response (GO:0002890)2.71345379
51negative regulation of B cell mediated immunity (GO:0002713)2.71345379
52respiratory burst (GO:0045730)2.70309374
53dendritic cell migration (GO:0036336)2.67648068
54positive regulation of p38MAPK cascade (GO:1900745)2.67632172
55germinal center formation (GO:0002467)2.67039961
56monoubiquitinated protein deubiquitination (GO:0035520)2.67002358
57activated T cell proliferation (GO:0050798)2.66843361
58negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.66770121
59positive regulation of granulocyte differentiation (GO:0030854)2.66525392
60positive regulation of leukocyte degranulation (GO:0043302)2.65298528
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.64714753
62leukocyte aggregation (GO:0070486)2.63187324
63positive regulation of histone deacetylation (GO:0031065)2.62302894
64regulation of tolerance induction (GO:0002643)2.61571413
65negative thymic T cell selection (GO:0045060)2.58240573
66negative T cell selection (GO:0043383)2.57900082
67regulation of interferon-alpha production (GO:0032647)2.57854186
68positive regulation of mast cell activation involved in immune response (GO:0033008)2.57782902
69positive regulation of mast cell degranulation (GO:0043306)2.57782902
70regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.56728182
71regulation of mast cell activation involved in immune response (GO:0033006)2.56649297
72negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.55310926
73regulation of mast cell degranulation (GO:0043304)2.54690349
74negative regulation of leukocyte mediated immunity (GO:0002704)2.54278152
75interleukin-6-mediated signaling pathway (GO:0070102)2.53894376
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.53567101
77cytoplasmic mRNA processing body assembly (GO:0033962)2.53500303
78protein localization to endosome (GO:0036010)2.53473619
79negative regulation of adaptive immune response (GO:0002820)2.51927700
80cellular response to interleukin-15 (GO:0071350)2.50951981
81regulation of interferon-beta biosynthetic process (GO:0045357)2.49724581
82negative regulation of complement activation (GO:0045916)2.49536150
83positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.48957368
84antigen processing and presentation via MHC class Ib (GO:0002475)2.48918381
85regulation of gamma-delta T cell differentiation (GO:0045586)2.48519221
86lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47219622
87phospholipid efflux (GO:0033700)2.46945996
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43859617
89establishment of protein localization to Golgi (GO:0072600)2.42172493
90JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.42087873
91protein targeting to Golgi (GO:0000042)2.41869447
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.40673403
93cell adhesion mediated by integrin (GO:0033627)2.40344758
94regulation of gamma-delta T cell activation (GO:0046643)2.39365213
95regulation of cholesterol homeostasis (GO:2000188)2.38028143
96positive regulation of glycogen biosynthetic process (GO:0045725)2.33718301
97positive regulation by symbiont of host defense response (GO:0052509)2.31541091
98modulation by symbiont of host defense response (GO:0052031)2.31541091
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.31541091
100modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.31541091
101positive regulation by organism of defense response of other organism involved in symbiotic interact2.31541091
102modulation by symbiont of host immune response (GO:0052553)2.31541091
103macroautophagy (GO:0016236)2.30508912
104positive regulation of fatty acid beta-oxidation (GO:0032000)2.29412542
105antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.25494980
106antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.25494980
107positive regulation of glycolytic process (GO:0045821)2.25404528
108histone H3-K36 demethylation (GO:0070544)2.25247835
109positive thymic T cell selection (GO:0045059)2.24332342
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.21169126
111positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.20722371
112cellular response to ethanol (GO:0071361)2.20458020
113positive regulation of cellular amide metabolic process (GO:0034250)2.20330248
114macrophage activation involved in immune response (GO:0002281)2.17911251
115protein-lipid complex assembly (GO:0065005)2.17365561
116I-kappaB phosphorylation (GO:0007252)2.16459571
117plasma lipoprotein particle assembly (GO:0034377)2.15061016
118phospholipid homeostasis (GO:0055091)2.13468788
119negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.12688776
120negative regulation of translation, ncRNA-mediated (GO:0040033)2.12688776
121regulation of translation, ncRNA-mediated (GO:0045974)2.12688776
122positive T cell selection (GO:0043368)2.11519621
123negative regulation of fatty acid transport (GO:2000192)2.08721343
124phospholipid translocation (GO:0045332)2.06810388
125lipid translocation (GO:0034204)2.06810388
126regulation of ARF protein signal transduction (GO:0032012)2.06008900
127antigen processing and presentation of endogenous antigen (GO:0019883)2.05881649
128lipoprotein transport (GO:0042953)2.04882783
129regulation of beta-amyloid formation (GO:1902003)2.02875233
130cholesterol efflux (GO:0033344)2.01944932
131apoptotic cell clearance (GO:0043277)2.01843184
132CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.00319371
133T-helper cell differentiation (GO:0042093)2.00319371
134positive regulation of glycogen metabolic process (GO:0070875)1.99514033
135positive regulation of cholesterol efflux (GO:0010875)1.98326409
136embryonic retina morphogenesis in camera-type eye (GO:0060059)1.97484059
137regulation of T cell tolerance induction (GO:0002664)1.96656048
138platelet-derived growth factor receptor signaling pathway (GO:0048008)1.96290143
139regulation of p38MAPK cascade (GO:1900744)1.95724794
140protein carboxylation (GO:0018214)1.95311071
141peptidyl-glutamic acid carboxylation (GO:0017187)1.95311071
142heterotypic cell-cell adhesion (GO:0034113)1.94117145
143response to growth hormone (GO:0060416)1.94087607
144substrate-dependent cell migration (GO:0006929)1.93324097
145positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.92863919
146regulation of macrophage derived foam cell differentiation (GO:0010743)1.92138093
147triglyceride-rich lipoprotein particle remodeling (GO:0034370)1.91192984
148positive regulation of cholesterol transport (GO:0032376)1.90982291
149positive regulation of sterol transport (GO:0032373)1.90982291
150negative regulation of B cell proliferation (GO:0030889)1.90778327
151reverse cholesterol transport (GO:0043691)1.90412152
152response to lipoprotein particle (GO:0055094)1.90183058
153positive regulation of fatty acid oxidation (GO:0046321)1.89482681
154endoplasmic reticulum organization (GO:0007029)1.87585031
155response to laminar fluid shear stress (GO:0034616)1.87573977
156nerve growth factor signaling pathway (GO:0038180)1.86776301
157response to fluid shear stress (GO:0034405)1.86718419
158negative regulation of bone resorption (GO:0045779)1.85104132
159gland morphogenesis (GO:0022612)1.84329179
160iron ion import (GO:0097286)1.83908661
161positive regulation of astrocyte differentiation (GO:0048711)1.81863737
162regulation of extracellular matrix disassembly (GO:0010715)1.81131782
163regulation of fatty acid beta-oxidation (GO:0031998)1.81118065
164COPII vesicle coating (GO:0048208)1.80889755
165germ cell migration (GO:0008354)1.80655059
166lipoprotein metabolic process (GO:0042157)1.78197231
167low-density lipoprotein particle clearance (GO:0034383)1.77783434
168positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003601.77338061
169regulation of membrane protein ectodomain proteolysis (GO:0051043)1.76915333
170regulation of bile acid biosynthetic process (GO:0070857)1.76456321
171regulation of glucose import in response to insulin stimulus (GO:2001273)1.76429668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74035234
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02668065
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62389237
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40838478
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38991137
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.29163653
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.00718602
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99885748
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96791891
10SMAD_19615063_ChIP-ChIP_OVARY_Human1.93847915
11LXR_22158963_ChIP-Seq_LIVER_Mouse1.86590979
12RUNX_20019798_ChIP-Seq_JUKART_Human1.85346736
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84618040
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80795688
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77384994
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76880426
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70036715
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69419066
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.67349392
20MYB_26560356_Chip-Seq_TH2_Human1.64278456
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.63926391
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.63650138
23CLOCK_20551151_ChIP-Seq_293T_Human1.63637254
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63043231
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.62031396
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.59397587
27TP53_16413492_ChIP-PET_HCT116_Human1.57126154
28GATA1_22025678_ChIP-Seq_K562_Human1.55992704
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.54383968
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54339350
31SCL_19346495_ChIP-Seq_HPC-7_Human1.51632759
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.50097251
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45127155
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44044242
35AR_21572438_ChIP-Seq_LNCaP_Human1.41368278
36SPI1_23547873_ChIP-Seq_NB4_Human1.41131786
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40205883
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40205883
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39176666
40SPI1_23127762_ChIP-Seq_K562_Human1.37918326
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.37645013
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.37276177
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35548592
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.35083874
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.33450737
46VDR_24787735_ChIP-Seq_THP-1_Human1.31721995
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31130569
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30828224
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30269951
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.30170953
51MYB_26560356_Chip-Seq_TH1_Human1.30039235
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29785433
53* GATA3_27048872_Chip-Seq_THYMUS_Human1.29454575
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28854202
55AHR_22903824_ChIP-Seq_MCF-7_Human1.28828704
56CJUN_26792858_Chip-Seq_BT549_Human1.28448051
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27558693
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.27264174
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.24065407
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.23454896
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22586752
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21316783
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21169174
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20806046
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20791041
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20136713
67GATA3_26560356_Chip-Seq_TH2_Human1.20035890
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18036850
69ER_23166858_ChIP-Seq_MCF-7_Human1.15744251
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15475085
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.13308647
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.11709508
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10574562
74TP53_18474530_ChIP-ChIP_U2OS_Human1.10149294
75TAF15_26573619_Chip-Seq_HEK293_Human1.09546435
76* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08425072
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06985419
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.06978310
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.06208249
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.05866129
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05315329
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04985218
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03810971
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.03248004
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03143746
86SOX2_20726797_ChIP-Seq_SW620_Human1.01246765
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00920996
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00349917
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99702238
90RXR_22108803_ChIP-Seq_LS180_Human0.99552023
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.99393220
92* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99169170
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98760437
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98640691
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98320119
96* TP63_23658742_ChIP-Seq_EP156T_Human0.98320076
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97963712
98BCAT_22108803_ChIP-Seq_LS180_Human0.97109342
99CDX2_22108803_ChIP-Seq_LS180_Human0.96931794
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.96487584
101STAT3_23295773_ChIP-Seq_U87_Human0.96198650
102SMRT_27268052_Chip-Seq_Bcells_Human0.96168103
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95999977
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95372337
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95179447
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95069483
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94796980
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94781043
109GATA1_19941826_ChIP-Seq_K562_Human0.94625419
110VDR_24763502_ChIP-Seq_THP-1_Human0.94569586
111MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94013014
112SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93853849
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93575616
114TCF7_22412390_ChIP-Seq_EML_Mouse0.93414825
115PU_27001747_Chip-Seq_BMDM_Mouse0.93363872
116P53_22387025_ChIP-Seq_ESCs_Mouse0.93254249
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93249350
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93249350
119BP1_19119308_ChIP-ChIP_Hs578T_Human0.92991862
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.92873012
121EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92420203
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92358834
123* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91898818
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.91774584
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91107260
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90916710
127BRD4_25478319_ChIP-Seq_HGPS_Human0.90454154
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90262185
129DROSHA_22980978_ChIP-Seq_HELA_Human0.90211652
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88918992
131POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88889156
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88587786
133SMAD4_21799915_ChIP-Seq_A2780_Human0.88513848
134IRF8_21731497_ChIP-ChIP_J774_Mouse0.87378544
135* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87182913
136* GATA2_19941826_ChIP-Seq_K562_Human0.86816806
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86814487
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86614530
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85227598
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84855355
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.84331181
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83952158
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83085345
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82449626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.51308363
2MP0000569_abnormal_digit_pigmentation3.32940095
3MP0008057_abnormal_DNA_replication2.56669626
4MP0002877_abnormal_melanocyte_morpholog2.51258186
5MP0003252_abnormal_bile_duct2.49167618
6MP0003183_abnormal_peptide_metabolism2.46710964
7MP0003303_peritoneal_inflammation2.46101153
8MP0010234_abnormal_vibrissa_follicle2.43847147
9MP0005360_urolithiasis2.38451829
10MP0002166_altered_tumor_susceptibility2.36839807
11MP0002139_abnormal_hepatobiliary_system2.26026461
12MP0009780_abnormal_chondrocyte_physiolo2.24277954
13MP0008438_abnormal_cutaneous_collagen2.22391086
14MP0002254_reproductive_system_inflammat2.10323419
15MP0002009_preneoplasia2.03243576
16MP0003705_abnormal_hypodermis_morpholog1.99817723
17MP0009785_altered_susceptibility_to1.98106476
18MP0003045_fibrosis1.97200640
19MP0005365_abnormal_bile_salt1.91024532
20MP0008260_abnormal_autophagy1.90255029
21MP0002138_abnormal_hepatobiliary_system1.89862601
22MP0003828_pulmonary_edema1.81270557
23MP0003787_abnormal_imprinting1.80055042
24MP0004883_abnormal_blood_vessel1.78238379
25MP0001835_abnormal_antigen_presentation1.77761445
26MP0004381_abnormal_hair_follicle1.72774962
27MP0003656_abnormal_erythrocyte_physiolo1.70944992
28MP0005076_abnormal_cell_differentiation1.66260293
29MP0005387_immune_system_phenotype1.64108409
30MP0001790_abnormal_immune_system1.64108409
31MP0002928_abnormal_bile_duct1.59531523
32MP0004947_skin_inflammation1.58731498
33MP0010352_gastrointestinal_tract_polyps1.57622604
34MP0002006_tumorigenesis1.57499162
35MP0003436_decreased_susceptibility_to1.57104026
36MP0002396_abnormal_hematopoietic_system1.56087934
37MP0005085_abnormal_gallbladder_physiolo1.52831860
38MP0002998_abnormal_bone_remodeling1.52569069
39MP0002148_abnormal_hypersensitivity_rea1.50743171
40MP0008961_abnormal_basal_metabolism1.49967089
41MP0003172_abnormal_lysosome_physiology1.49711673
42MP0005451_abnormal_body_composition1.49453552
43MP0005275_abnormal_skin_tensile1.48775494
44MP0005164_abnormal_response_to1.46802943
45MP0001666_abnormal_nutrient_absorption1.46523034
46MP0003091_abnormal_cell_migration1.45118528
47MP0010329_abnormal_lipoprotein_level1.43137626
48MP0003690_abnormal_glial_cell1.39755586
49MP0003868_abnormal_feces_composition1.39075379
50* MP0000716_abnormal_immune_system1.34528668
51MP0004130_abnormal_muscle_cell1.34194924
52MP0000015_abnormal_ear_pigmentation1.32574770
53* MP0002398_abnormal_bone_marrow1.31602596
54MP0009384_cardiac_valve_regurgitation1.30229821
55MP0000604_amyloidosis1.25714260
56MP0002419_abnormal_innate_immunity1.25698294
57MP0005000_abnormal_immune_tolerance1.25591144
58MP0002896_abnormal_bone_mineralization1.24643548
59MP0003279_aneurysm1.23676105
60MP0000689_abnormal_spleen_morphology1.22787778
61MP0008875_abnormal_xenobiotic_pharmacok1.22625010
62MP0005075_abnormal_melanosome_morpholog1.22475179
63MP0003724_increased_susceptibility_to1.22415862
64MP0001851_eye_inflammation1.22356377
65MP0001800_abnormal_humoral_immune1.21987720
66MP0003191_abnormal_cellular_cholesterol1.20870379
67MP0005310_abnormal_salivary_gland1.19580160
68MP0000685_abnormal_immune_system1.16896331
69MP0001533_abnormal_skeleton_physiology1.16000308
70MP0002452_abnormal_antigen_presenting1.15896329
71MP0000609_abnormal_liver_physiology1.14436286
72MP0006054_spinal_hemorrhage1.13501335
73MP0004510_myositis1.13360422
74MP0002722_abnormal_immune_system1.12196723
75MP0000371_diluted_coat_color1.12073420
76MP0004808_abnormal_hematopoietic_stem1.10658497
77MP0005397_hematopoietic_system_phenotyp1.09834876
78MP0001545_abnormal_hematopoietic_system1.09834876
79MP0002168_other_aberrant_phenotype1.09508812
80MP0006082_CNS_inflammation1.08555838
81MP0003566_abnormal_cell_adhesion1.07508778
82MP0010155_abnormal_intestine_physiology1.07124278
83MP0008469_abnormal_protein_level1.07078449
84MP0009764_decreased_sensitivity_to1.06305744
85* MP0002723_abnormal_immune_serum1.05002963
86MP0005174_abnormal_tail_pigmentation1.04919096
87MP0002277_abnormal_respiratory_mucosa1.04842501
88MP0000703_abnormal_thymus_morphology1.04791254
89MP0005220_abnormal_exocrine_pancreas1.03436770
90MP0002060_abnormal_skin_morphology1.02616546
91MP0000427_abnormal_hair_cycle1.02518197
92MP0002909_abnormal_adrenal_gland1.01957079
93MP0010678_abnormal_skin_adnexa1.01182135
94MP0001853_heart_inflammation0.99416125
95MP0001299_abnormal_eye_distance/0.99125605
96MP0009278_abnormal_bone_marrow0.98749377
97MP0005671_abnormal_response_to0.98524781
98MP0000013_abnormal_adipose_tissue0.97181132
99MP0003453_abnormal_keratinocyte_physiol0.96380003
100MP0005464_abnormal_platelet_physiology0.95797381
101* MP0002429_abnormal_blood_cell0.93802745
102MP0004185_abnormal_adipocyte_glucose0.93756572
103MP0000465_gastrointestinal_hemorrhage0.93403933
104MP0001845_abnormal_inflammatory_respons0.91996233
105MP0005058_abnormal_lysosome_morphology0.91497523
106* MP0001819_abnormal_immune_cell0.91198560
107* MP0002420_abnormal_adaptive_immunity0.91100845
108MP0001944_abnormal_pancreas_morphology0.90706638
109MP0004484_altered_response_of0.90132663
110MP0001958_emphysema0.89706406
111MP0003221_abnormal_cardiomyocyte_apopto0.89510468
112MP0009115_abnormal_fat_cell0.89302575
113MP0005409_darkened_coat_color0.89211763
114MP0002090_abnormal_vision0.89187583
115MP0000383_abnormal_hair_follicle0.88791621
116MP0008877_abnormal_DNA_methylation0.88767865
117MP0005334_abnormal_fat_pad0.88574387
118MP0002132_abnormal_respiratory_system0.87650149
119MP0002693_abnormal_pancreas_physiology0.87405818
120MP0002933_joint_inflammation0.86870787
121MP0002971_abnormal_brown_adipose0.86412188
122MP0003195_calcinosis0.85515498
123MP0003795_abnormal_bone_structure0.84736572
124MP0005666_abnormal_adipose_tissue0.83162258
125MP0005166_decreased_susceptibility_to0.82726486
126MP0002118_abnormal_lipid_homeostasis0.81976884
127MP0001879_abnormal_lymphatic_vessel0.79880986
128MP0003448_altered_tumor_morphology0.79794991
129MP0005375_adipose_tissue_phenotype0.78850049
130MP0002405_respiratory_system_inflammati0.78844500
131MP0001873_stomach_inflammation0.78476926
132MP0003866_abnormal_defecation0.76816380
133MP0009840_abnormal_foam_cell0.76488357
134MP0000249_abnormal_blood_vessel0.75462304
135MP0005257_abnormal_intraocular_pressure0.74525793
136MP0003075_altered_response_to0.74021443
137MP0005025_abnormal_response_to0.73499520
138MP0000858_altered_metastatic_potential0.72989062
139MP0003763_abnormal_thymus_physiology0.72449179
140MP0004019_abnormal_vitamin_homeostasis0.71985067
141MP0010368_abnormal_lymphatic_system0.71679635
142MP0005670_abnormal_white_adipose0.71677173
143MP0005376_homeostasis/metabolism_phenot0.67917333
144MP0002332_abnormal_exercise_endurance0.67075166

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.54678950
2Papillary thyroid carcinoma (HP:0002895)3.60198989
3Abnormality of macrophages (HP:0004311)3.52178065
4Stomatitis (HP:0010280)3.38700660
5Myocardial infarction (HP:0001658)3.30613289
6Recurrent skin infections (HP:0001581)3.25689790
7Keratoconjunctivitis sicca (HP:0001097)2.92641660
8Elevated erythrocyte sedimentation rate (HP:0003565)2.90354638
9Mediastinal lymphadenopathy (HP:0100721)2.81204029
10Recurrent cutaneous fungal infections (HP:0011370)2.73054219
11Chronic mucocutaneous candidiasis (HP:0002728)2.73054219
12Hematochezia (HP:0002573)2.69308221
13Keratoconjunctivitis (HP:0001096)2.68146966
14Cerebral aneurysm (HP:0004944)2.65752323
15Xanthomatosis (HP:0000991)2.62207653
16Macroorchidism (HP:0000053)2.62179269
17Mitral valve prolapse (HP:0001634)2.61832199
18Aortic aneurysm (HP:0004942)2.58197065
19Subacute progressive viral hepatitis (HP:0006572)2.54541037
20Pulmonary infiltrates (HP:0002113)2.51035419
21Chest pain (HP:0100749)2.50573886
22Hemoptysis (HP:0002105)2.48888434
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.47510534
24Thyroid carcinoma (HP:0002890)2.45657269
25Eczematoid dermatitis (HP:0000976)2.44740912
26Abnormality of the common coagulation pathway (HP:0010990)2.40458397
27Meningitis (HP:0001287)2.40418835
28Arterial tortuosity (HP:0005116)2.39596022
29Complement deficiency (HP:0004431)2.35522883
30Curly hair (HP:0002212)2.34215301
31Mitral stenosis (HP:0001718)2.31624547
32Pulmonary embolism (HP:0002204)2.28184080
33Dilatation of the ascending aorta (HP:0005111)2.28032755
34Spondylolisthesis (HP:0003302)2.27918930
35Dysostosis multiplex (HP:0000943)2.26591952
36Absent frontal sinuses (HP:0002688)2.24757864
37Epidermoid cyst (HP:0200040)2.24341806
38Osteolytic defects of the hand bones (HP:0009699)2.23860470
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.23860470
40Leukocytosis (HP:0001974)2.22873431
41Thick nail (HP:0001805)2.22635296
42Aortic dissection (HP:0002647)2.20185343
43Vascular tortuosity (HP:0004948)2.17849223
44Encephalitis (HP:0002383)2.17151439
45Fair hair (HP:0002286)2.15874751
46Persistence of primary teeth (HP:0006335)2.15698723
47Neoplasm of the tracheobronchial system (HP:0100552)2.15650118
48Abnormality of the fingertips (HP:0001211)2.15240528
49Mucopolysacchariduria (HP:0008155)2.14216444
50Urinary glycosaminoglycan excretion (HP:0003541)2.14216444
51Viral hepatitis (HP:0006562)2.13614257
52Prolonged bleeding time (HP:0003010)2.11244888
53Deep venous thrombosis (HP:0002625)2.11208373
54Episodic fever (HP:0001954)2.10607381
55Osteomyelitis (HP:0002754)2.10557066
56Amyloidosis (HP:0011034)2.09830202
57Hypoglycemic seizures (HP:0002173)2.08932018
58Systemic lupus erythematosus (HP:0002725)2.07693609
59Urticaria (HP:0001025)2.06466473
60Abnormality of T cells (HP:0002843)2.06364194
61Recurrent bronchitis (HP:0002837)2.05290781
62Generalized hypopigmentation of hair (HP:0011358)2.05254197
63Abnormality of liposaccharide metabolism (HP:0010968)2.03970456
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.03970456
65Abnormality of glycolipid metabolism (HP:0010969)2.03970456
66Increased CSF protein (HP:0002922)2.02549992
67Conjugated hyperbilirubinemia (HP:0002908)2.02172900
68Thickened calvaria (HP:0002684)2.01661152
69Menstrual irregularities (HP:0000858)2.01497893
70Coarse hair (HP:0002208)2.01446009
71Periodontitis (HP:0000704)2.00978566
72Gangrene (HP:0100758)2.00950677
73Abnormality of complement system (HP:0005339)2.00451880
74Acute myeloid leukemia (HP:0004808)2.00341759
75Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99505022
76Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99505022
77Abnormality of polysaccharide metabolism (HP:0011012)1.99505022
78Autoimmune hemolytic anemia (HP:0001890)1.96076909
79Arterial thrombosis (HP:0004420)1.94505670
80Epistaxis (HP:0000421)1.94450963
81Abnormality of proline metabolism (HP:0010907)1.94412922
82Hydroxyprolinuria (HP:0003080)1.94412922
83Intrahepatic cholestasis (HP:0001406)1.94391628
84T lymphocytopenia (HP:0005403)1.94332937
85Widely spaced teeth (HP:0000687)1.93546496
86Chronic diarrhea (HP:0002028)1.90299000
87Abnormality of T cell number (HP:0011839)1.89848183
88Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89201341
89Spinal cord lesions (HP:0100561)1.86321604
90Syringomyelia (HP:0003396)1.86321604
91Obstructive lung disease (HP:0006536)1.86260170
92Chronic obstructive pulmonary disease (HP:0006510)1.86260170
93Neonatal hypoglycemia (HP:0001998)1.85459174
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85023713
95Slow saccadic eye movements (HP:0000514)1.84090871
96Striae distensae (HP:0001065)1.83527048
97Hypoalphalipoproteinemia (HP:0003233)1.83438506
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82857284
99Pustule (HP:0200039)1.82374116
100Inflammation of the large intestine (HP:0002037)1.80823282
101Aneurysm (HP:0002617)1.80568908
102Eosinophilia (HP:0001880)1.78935726
103Anorexia (HP:0002039)1.78377022
104Inappropriate behavior (HP:0000719)1.78258927
105Thyroiditis (HP:0100646)1.77674689
106Gastrointestinal infarctions (HP:0005244)1.77332994
107Increased IgE level (HP:0003212)1.77174734
108Acute hepatic failure (HP:0006554)1.77127854
109Testicular neoplasm (HP:0010788)1.77105752
110Skin nodule (HP:0200036)1.76784295
111Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76441914
112Cellulitis (HP:0100658)1.76270270
113Hypochromic microcytic anemia (HP:0004840)1.75705623
114Recurrent gram-negative bacterial infections (HP:0005420)1.75456732
115Bladder carcinoma (HP:0002862)1.74711410
116Bladder neoplasm (HP:0009725)1.74711410
117Gingival bleeding (HP:0000225)1.74567649
118Narrow palate (HP:0000189)1.73899203
119Nephritis (HP:0000123)1.73822637
120Truncal obesity (HP:0001956)1.73542843
121Hyperglycemia (HP:0003074)1.72201370
122Hypercholesterolemia (HP:0003124)1.72142879
123Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72033797
124Cubitus valgus (HP:0002967)1.71902693
125Rectal prolapse (HP:0002035)1.71718022
126Transitional cell carcinoma of the bladder (HP:0006740)1.70882563
127Symptomatic seizures (HP:0011145)1.70007178
128Abnormality of the endocardium (HP:0004306)1.67794524
129Recurrent fungal infections (HP:0002841)1.66658322
130Alveolar cell carcinoma (HP:0006519)1.66425838
131Hepatocellular carcinoma (HP:0001402)1.65920246
132Esophageal varix (HP:0002040)1.65155315
133Abnormality of the axillary hair (HP:0100134)1.64858330
134Abnormality of the frontal sinuses (HP:0002687)1.64381451
135Disinhibition (HP:0000734)1.63957577
136Increased density of long bones (HP:0006392)1.63769456
137Myositis (HP:0100614)1.61574444
138Papilledema (HP:0001085)1.61149618
139Glomerulonephritis (HP:0000099)1.59609463
140Recurrent bacterial skin infections (HP:0005406)1.59236824
141Orchitis (HP:0100796)1.58900561
142Retinal atrophy (HP:0001105)1.58712588
143Optic neuritis (HP:0100653)1.57823504
144Retrobulbar optic neuritis (HP:0100654)1.57823504
145Spontaneous hematomas (HP:0007420)1.56955525
146Abnormality of the intrinsic pathway (HP:0010989)1.56177695
147Increased mean platelet volume (HP:0011877)1.55651909
148Atrophic scars (HP:0001075)1.53715191
149Tibial bowing (HP:0002982)1.53517683
150Autoimmune thrombocytopenia (HP:0001973)1.52780944
151Abdominal distention (HP:0003270)1.52393344
152Joint hemorrhage (HP:0005261)1.51900681
153Broad ribs (HP:0000885)1.51511388
154Abnormal platelet volume (HP:0011876)1.51277583
155Peritonitis (HP:0002586)1.51243126
156Shallow orbits (HP:0000586)1.51164632
157Gingivitis (HP:0000230)1.50782883
158Disproportionate tall stature (HP:0001519)1.50728006
159Vasculitis (HP:0002633)1.49869814
160Submucous cleft hard palate (HP:0000176)1.49393403
161Recurrent viral infections (HP:0004429)1.48853766
162Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.48821348
163Abnormality of the nasal septum (HP:0000419)1.48302226
164Hemorrhage of the eye (HP:0011885)1.48085305
165Abnormal foot bone ossification (HP:0010675)1.47958097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.56002894
2BLK2.55285569
3TAOK32.16325116
4JAK12.03574128
5BMPR21.99560533
6NUAK11.97068090
7MAP3K141.92204063
8FGFR31.91837675
9SIK11.85364982
10EPHB11.84444560
11RIPK11.79959888
12ACVR1B1.78477654
13CAMK1D1.78449500
14MAP2K31.77825835
15INSRR1.76358910
16MAP3K101.75814168
17TGFBR21.74442820
18JAK31.68548514
19YES11.68138391
20AKT31.63434660
21FGFR41.61130259
22LATS11.57601776
23EPHA31.57123818
24CAMK1G1.56314619
25PTK61.54030355
26TYK21.50664517
27GRK61.46780658
28FGFR21.44076483
29PDGFRB1.43507005
30SCYL21.40325459
31IRAK21.37528532
32ITK1.33768901
33TRIB31.33077256
34MAPK151.30763583
35BTK1.28249974
36PRPF4B1.24747666
37MAP3K11.24481539
38ZAP701.24107631
39ERN11.21676682
40SGK31.21473920
41TEC1.21217821
42SYK1.20423666
43CAMKK21.20054242
44MAP3K131.19305422
45CSK1.16210215
46HIPK21.15321343
47CSF1R1.14952035
48STK241.11860871
49PDGFRA1.07986010
50MAP4K11.07640647
51RET1.07536306
52JAK21.06455504
53TXK1.06439832
54TTN1.06266487
55KSR11.04454879
56TBK11.02607290
57MAP3K61.01642832
58PRKCH1.01282976
59CDK60.98541335
60PIK3CA0.98473730
61IKBKE0.97898917
62BRD40.97605281
63MAPK70.96072998
64SGK20.95474815
65LYN0.95266695
66KSR20.92139978
67PTK20.91957286
68HCK0.88556136
69IRAK30.88483758
70MARK30.84530552
71STK100.83667630
72IKBKB0.82635513
73CHUK0.79446810
74CDK120.79251421
75MAP3K70.78597150
76FES0.78478439
77SIK30.78346599
78PTK2B0.77787155
79PRKCQ0.74921287
80TAOK10.72097257
81FLT30.71692196
82KIT0.70617112
83DDR20.70365634
84MAP2K40.70213951
85MARK20.69984996
86STK30.69117245
87DMPK0.68915982
88PAK30.68842085
89LCK0.68641324
90ERBB30.68566041
91MELK0.68085142
92TRPM70.68018718
93IRAK40.67764415
94PDK10.67032881
95PRKAA20.65691658
96LRRK20.65491198
97NEK60.65345816
98IRAK10.65096284
99MST1R0.64539380
100INSR0.63229879
101DYRK1B0.63224013
102NLK0.63116264
103GSK3A0.62924119
104STK110.62719172
105FGR0.62473406
106FER0.61959972
107PIK3CG0.60442806
108EIF2AK30.60289860
109TNK20.60119915
110PDPK10.59701992
111MAP3K30.59272771
112MAP3K40.58921340
113IGF1R0.57688566
114* MAP3K20.57285853
115CDK90.56972033
116BMX0.56155153
117SGK2230.54952474
118SGK4940.54952474
119CAMKK10.54760625
120MAP3K50.54187173
121MST40.53601054
122RAF10.53574780
123OXSR10.53427014
124NEK90.53208594
125STK38L0.52899126
126WNK10.52605142
127SIK20.52286399
128PKN20.52037688
129FYN0.51600882
130RPS6KA20.51345941
131RIPK40.48961366
132MATK0.48090380
133MAP3K90.47531074
134SGK10.47143120
135RPS6KB10.47129805
136EGFR0.47124517
137PIM10.46259347

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009101.72630177
2Osteoclast differentiation_Homo sapiens_hsa043801.60472054
3Maturity onset diabetes of the young_Homo sapiens_hsa049501.51457642
4Type II diabetes mellitus_Homo sapiens_hsa049301.50881064
5Legionellosis_Homo sapiens_hsa051341.47085598
6Staphylococcus aureus infection_Homo sapiens_hsa051501.36514301
7Complement and coagulation cascades_Homo sapiens_hsa046101.35623109
8Type I diabetes mellitus_Homo sapiens_hsa049401.35432737
9Graft-versus-host disease_Homo sapiens_hsa053321.31094095
10B cell receptor signaling pathway_Homo sapiens_hsa046621.30599773
11Influenza A_Homo sapiens_hsa051641.25021309
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24384416
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.22818335
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22037756
15Allograft rejection_Homo sapiens_hsa053301.19800207
16Leishmaniasis_Homo sapiens_hsa051401.17297242
17Toxoplasmosis_Homo sapiens_hsa051451.15528783
18Autoimmune thyroid disease_Homo sapiens_hsa053201.15482542
19T cell receptor signaling pathway_Homo sapiens_hsa046601.14432602
20Insulin resistance_Homo sapiens_hsa049311.13703128
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13308428
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12755023
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10840238
24ABC transporters_Homo sapiens_hsa020101.10094681
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06287452
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06231514
27Lysine degradation_Homo sapiens_hsa003101.01651249
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.01536955
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01415131
30Phagosome_Homo sapiens_hsa041451.00867998
31TNF signaling pathway_Homo sapiens_hsa046680.99537909
32Regulation of autophagy_Homo sapiens_hsa041400.98711891
33Chronic myeloid leukemia_Homo sapiens_hsa052200.98064672
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97832363
35Dorso-ventral axis formation_Homo sapiens_hsa043200.97432450
36Prolactin signaling pathway_Homo sapiens_hsa049170.96138759
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93809185
38Focal adhesion_Homo sapiens_hsa045100.93743793
39mTOR signaling pathway_Homo sapiens_hsa041500.93216121
40Caffeine metabolism_Homo sapiens_hsa002320.92693805
41Sphingolipid signaling pathway_Homo sapiens_hsa040710.92422859
42Adipocytokine signaling pathway_Homo sapiens_hsa049200.91766081
43Sulfur metabolism_Homo sapiens_hsa009200.90068020
44Other glycan degradation_Homo sapiens_hsa005110.89578292
45Herpes simplex infection_Homo sapiens_hsa051680.89349858
46Pancreatic cancer_Homo sapiens_hsa052120.88888716
47Proteoglycans in cancer_Homo sapiens_hsa052050.86767975
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86607807
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.85535402
50Amoebiasis_Homo sapiens_hsa051460.84982037
51Chemokine signaling pathway_Homo sapiens_hsa040620.84310409
52Platelet activation_Homo sapiens_hsa046110.83784312
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82029681
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81510567
55Lysosome_Homo sapiens_hsa041420.81165018
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80422502
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79051192
58Bile secretion_Homo sapiens_hsa049760.78358311
59Malaria_Homo sapiens_hsa051440.77360578
60Renal cell carcinoma_Homo sapiens_hsa052110.77236722
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76659548
62VEGF signaling pathway_Homo sapiens_hsa043700.76387373
63Asthma_Homo sapiens_hsa053100.76048588
64Tuberculosis_Homo sapiens_hsa051520.75947211
65Acute myeloid leukemia_Homo sapiens_hsa052210.75441719
66FoxO signaling pathway_Homo sapiens_hsa040680.74643445
67PPAR signaling pathway_Homo sapiens_hsa033200.74263856
68Measles_Homo sapiens_hsa051620.73731414
69Pertussis_Homo sapiens_hsa051330.73574418
70ECM-receptor interaction_Homo sapiens_hsa045120.73550559
71Antigen processing and presentation_Homo sapiens_hsa046120.73134998
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73108336
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.72868123
74Endometrial cancer_Homo sapiens_hsa052130.72808021
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72610070
76Prostate cancer_Homo sapiens_hsa052150.72436360
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.71419620
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71295955
79Adherens junction_Homo sapiens_hsa045200.70520120
80Small cell lung cancer_Homo sapiens_hsa052220.69833990
81Rheumatoid arthritis_Homo sapiens_hsa053230.68765148
82Starch and sucrose metabolism_Homo sapiens_hsa005000.68362418
83Renin secretion_Homo sapiens_hsa049240.67675408
84Choline metabolism in cancer_Homo sapiens_hsa052310.66513934
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66507258
86Estrogen signaling pathway_Homo sapiens_hsa049150.66481767
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66433365
88Prion diseases_Homo sapiens_hsa050200.66280192
89Hepatitis C_Homo sapiens_hsa051600.66070366
90Glioma_Homo sapiens_hsa052140.65922800
91Tryptophan metabolism_Homo sapiens_hsa003800.64847948
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64726870
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63694684
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.62824626
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.62338082
96Circadian rhythm_Homo sapiens_hsa047100.61795347
97HIF-1 signaling pathway_Homo sapiens_hsa040660.61329333
98Salmonella infection_Homo sapiens_hsa051320.61009075
99ErbB signaling pathway_Homo sapiens_hsa040120.59906278
100Apoptosis_Homo sapiens_hsa042100.59473469
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59296455
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58581895
103Hepatitis B_Homo sapiens_hsa051610.57905964
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.57025492
105Hematopoietic cell lineage_Homo sapiens_hsa046400.56804632
106African trypanosomiasis_Homo sapiens_hsa051430.56636971
107* GnRH signaling pathway_Homo sapiens_hsa049120.56278891
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55717314
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55432072
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55407912
111Inositol phosphate metabolism_Homo sapiens_hsa005620.54730457
112Colorectal cancer_Homo sapiens_hsa052100.54182130
113Viral carcinogenesis_Homo sapiens_hsa052030.54085943
114Sphingolipid metabolism_Homo sapiens_hsa006000.53608180
115Non-small cell lung cancer_Homo sapiens_hsa052230.53539526
116Arginine biosynthesis_Homo sapiens_hsa002200.53241747
117Primary immunodeficiency_Homo sapiens_hsa053400.51906587
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51503829
119Fatty acid degradation_Homo sapiens_hsa000710.51329148
120Thyroid hormone synthesis_Homo sapiens_hsa049180.51002395
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50326322
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50101603
123Thyroid cancer_Homo sapiens_hsa052160.49948260
124Fat digestion and absorption_Homo sapiens_hsa049750.49469471
125Viral myocarditis_Homo sapiens_hsa054160.49264631
126Insulin signaling pathway_Homo sapiens_hsa049100.49225157
127Butanoate metabolism_Homo sapiens_hsa006500.49132197
128Endocytosis_Homo sapiens_hsa041440.48918913
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48579811
130Long-term potentiation_Homo sapiens_hsa047200.48118088
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48086089
132Renin-angiotensin system_Homo sapiens_hsa046140.47686853

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