MAP3K3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of other organism (GO:0098543)4.79899874
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.59229729
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.59229729
4positive regulation of gamma-delta T cell activation (GO:0046645)4.54061993
5detection of bacterium (GO:0016045)4.53368405
6antigen processing and presentation of endogenous antigen (GO:0019883)4.28683541
7detection of external biotic stimulus (GO:0098581)4.15983038
8detection of molecule of bacterial origin (GO:0032490)4.15525592
9regulation of gamma-delta T cell differentiation (GO:0045586)4.02450974
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79674481
11regulation of gamma-delta T cell activation (GO:0046643)3.78445988
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72208141
13negative regulation of lymphocyte mediated immunity (GO:0002707)3.68220950
14detection of biotic stimulus (GO:0009595)3.66987595
15neutrophil activation (GO:0042119)3.58860387
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55549075
17response to host immune response (GO:0052572)3.55549075
18regulation of B cell receptor signaling pathway (GO:0050855)3.49523308
19regulation of interleukin-12 biosynthetic process (GO:0045075)3.48109751
20regulation of interferon-beta biosynthetic process (GO:0045357)3.46220196
21negative regulation of phagocytosis (GO:0050765)3.45850629
22regulation of mast cell degranulation (GO:0043304)3.44438945
23macrophage activation (GO:0042116)3.41501914
24positive thymic T cell selection (GO:0045059)3.40073536
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40072073
26negative regulation of cell killing (GO:0031342)3.40072073
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36086640
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.36086640
29modulation by symbiont of host immune response (GO:0052553)3.36086640
30positive regulation by symbiont of host defense response (GO:0052509)3.36086640
31modulation by symbiont of host defense response (GO:0052031)3.36086640
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36086640
33negative regulation of leukocyte mediated immunity (GO:0002704)3.35944223
34respiratory burst (GO:0045730)3.33363656
35granulocyte activation (GO:0036230)3.32106318
36leukocyte migration involved in inflammatory response (GO:0002523)3.29002775
37regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27872579
38myeloid cell activation involved in immune response (GO:0002275)3.27515360
39negative regulation of T cell mediated immunity (GO:0002710)3.27272713
40regulation of leukocyte degranulation (GO:0043300)3.26915993
41microglial cell activation (GO:0001774)3.26015970
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23256386
43positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22668397
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21753558
45positive regulation of histone deacetylation (GO:0031065)3.19655801
46regulation of mast cell activation involved in immune response (GO:0033006)3.13139666
47germinal center formation (GO:0002467)3.12942243
48positive regulation of B cell differentiation (GO:0045579)3.07782286
49positive regulation of mast cell activation (GO:0033005)3.06894793
50cellular extravasation (GO:0045123)3.06248812
51negative regulation of granulocyte differentiation (GO:0030853)3.03171063
52neutrophil mediated immunity (GO:0002446)3.01988229
53response to muramyl dipeptide (GO:0032495)3.01840882
54cellular response to interleukin-15 (GO:0071350)3.00426415
55regulation of T-helper 2 cell differentiation (GO:0045628)2.93665600
56response to laminar fluid shear stress (GO:0034616)2.93144389
57macrophage activation involved in immune response (GO:0002281)2.90252651
58production of molecular mediator involved in inflammatory response (GO:0002532)2.90242522
59morphogenesis of an endothelium (GO:0003159)2.88555809
60endothelial tube morphogenesis (GO:0061154)2.88555809
61regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88006633
62lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86572901
63regulation of mast cell activation (GO:0033003)2.85252472
64regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.85165442
65response to type I interferon (GO:0034340)2.83611413
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83412227
67positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.83340348
68cellular response to type I interferon (GO:0071357)2.83249585
69type I interferon signaling pathway (GO:0060337)2.83249585
70B cell receptor signaling pathway (GO:0050853)2.82216985
71negative regulation of interleukin-12 production (GO:0032695)2.81358453
72JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.80914110
73negative regulation of innate immune response (GO:0045824)2.79906554
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78617606
75vascular endothelial growth factor signaling pathway (GO:0038084)2.77294005
76regulation of regulated secretory pathway (GO:1903305)2.73215683
77positive regulation of cellular amide metabolic process (GO:0034250)2.72030763
78regulation of B cell differentiation (GO:0045577)2.71341554
79defense response to protozoan (GO:0042832)2.71196961
80regulation of necroptotic process (GO:0060544)2.70250941
81thymic T cell selection (GO:0045061)2.69962613
82angiogenesis involved in wound healing (GO:0060055)2.68606459
83NIK/NF-kappaB signaling (GO:0038061)2.67887326
84positive regulation of interferon-alpha production (GO:0032727)2.67263883
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66453750
86negative regulation of type 2 immune response (GO:0002829)2.66178683
87leukocyte degranulation (GO:0043299)2.65978528
88interferon-gamma-mediated signaling pathway (GO:0060333)2.64753195
89regulation of macrophage cytokine production (GO:0010935)2.63537608
90negative regulation of cytokine production involved in immune response (GO:0002719)2.62992862
91negative regulation of T-helper cell differentiation (GO:0045623)2.62039099
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62039099
93positive regulation of mast cell activation involved in immune response (GO:0033008)2.60732944
94response to fluid shear stress (GO:0034405)2.60675765
95definitive hemopoiesis (GO:0060216)2.60276277
96apoptotic cell clearance (GO:0043277)2.59028790
97cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.58876281
98mannose metabolic process (GO:0006013)2.57454435
99negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57189274
100response to peptidoglycan (GO:0032494)2.54459144
101germ cell migration (GO:0008354)2.54419449
102negative thymic T cell selection (GO:0045060)2.54131983
103pre-miRNA processing (GO:0031054)2.53430547
104negative regulation of stress fiber assembly (GO:0051497)2.52299804
105antigen processing and presentation via MHC class Ib (GO:0002475)2.51822069
106positive regulation of tolerance induction (GO:0002645)2.51128326
107pinocytosis (GO:0006907)2.49959402
108regulation of interferon-alpha production (GO:0032647)2.49356620
109growth hormone receptor signaling pathway (GO:0060396)2.48545483
110positive regulation of SMAD protein import into nucleus (GO:0060391)2.48537442
111positive T cell selection (GO:0043368)2.48014757
112protein localization to endosome (GO:0036010)2.47070062
113negative T cell selection (GO:0043383)2.46288218
114immunoglobulin mediated immune response (GO:0016064)2.45968941
115negative regulation of erythrocyte differentiation (GO:0045647)2.45032596
116nodal signaling pathway (GO:0038092)2.44278256
117natural killer cell differentiation (GO:0001779)2.43901322
118cell adhesion mediated by integrin (GO:0033627)2.43577653
119regulation of SMAD protein import into nucleus (GO:0060390)2.42960826
120leukocyte aggregation (GO:0070486)2.41012391
121histone H2A monoubiquitination (GO:0035518)2.40525727
122positive regulation of protein deacetylation (GO:0090312)2.40201693
123T cell selection (GO:0045058)2.35710456
124regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32981004
125positive regulation of antigen processing and presentation (GO:0002579)2.32793296
126regulation of integrin activation (GO:0033623)2.31868513
127endodermal cell differentiation (GO:0035987)2.31019188
128negative regulation of bone resorption (GO:0045779)2.30563270
129endothelial cell chemotaxis (GO:0035767)2.30526294
130response to host (GO:0075136)2.29956649
131response to host defenses (GO:0052200)2.29956649
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.29956649
133tolerance induction (GO:0002507)2.29335926
134substrate-dependent cell migration (GO:0006929)2.28585181
135regulation of T cell tolerance induction (GO:0002664)2.27547157
136blood vessel maturation (GO:0001955)2.27286919
137positive regulation of interferon-beta production (GO:0032728)2.26772771
138I-kappaB phosphorylation (GO:0007252)2.26605650
139regulation of tolerance induction (GO:0002643)2.26596947
140cytoplasmic mRNA processing body assembly (GO:0033962)2.26510768
141positive regulation of lamellipodium assembly (GO:0010592)2.26227537
142cortical actin cytoskeleton organization (GO:0030866)2.26054169
143neutrophil activation involved in immune response (GO:0002283)2.24738274
144establishment of endothelial barrier (GO:0061028)2.24100961
145regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.23846145
146negative regulation of interleukin-6 production (GO:0032715)2.23414172
147response to interleukin-15 (GO:0070672)2.23291385
148regulation of response to interferon-gamma (GO:0060330)2.23207395
149cellular response to zinc ion (GO:0071294)2.22885565
150nuclear pore complex assembly (GO:0051292)2.22145283
151leukocyte cell-cell adhesion (GO:0007159)2.21394478
152negative regulation of fatty acid transport (GO:2000192)2.20983986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.16866166
2E2F7_22180533_ChIP-Seq_HELA_Human3.90903634
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.83587891
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58123362
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53908092
6MYC_22102868_ChIP-Seq_BL_Human3.18325240
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.97310635
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.78765804
9VDR_21846776_ChIP-Seq_THP-1_Human2.63020712
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58880853
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.50169444
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43982202
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40068188
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36032605
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.35753992
16TCF7_22412390_ChIP-Seq_EML_Mouse2.31891047
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27255106
18MAF_26560356_Chip-Seq_TH1_Human2.18829321
19* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15403388
20* ELK3_25401928_ChIP-Seq_HUVEC_Human2.10130307
21SCL_19346495_ChIP-Seq_HPC-7_Human2.06343498
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04217545
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98984920
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95573169
25RUNX_20019798_ChIP-Seq_JUKART_Human1.95484854
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93236693
27KDM2B_26808549_Chip-Seq_DND41_Human1.92785875
28UTX_26944678_Chip-Seq_JUKART_Human1.91119802
29MYB_26560356_Chip-Seq_TH2_Human1.90602344
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89358817
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86244751
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86205313
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84823193
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84247908
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81216105
36MYB_26560356_Chip-Seq_TH1_Human1.81001045
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79445007
38VDR_24763502_ChIP-Seq_THP-1_Human1.76438072
39CLOCK_20551151_ChIP-Seq_293T_Human1.75393249
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.68414088
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.67312303
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66606703
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65826138
44SPI1_23127762_ChIP-Seq_K562_Human1.63877936
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.62462175
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57272850
47SPI1_23547873_ChIP-Seq_NB4_Human1.57078448
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54735436
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.54515144
50VDR_24787735_ChIP-Seq_THP-1_Human1.51571049
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51010592
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49696151
53* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42466958
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39847723
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37546759
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36234855
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36038453
58* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34500019
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33924595
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30171922
61MAF_26560356_Chip-Seq_TH2_Human1.29967482
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.28993048
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28460408
64* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27920800
65NCOR1_26117541_ChIP-Seq_K562_Human1.27418195
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25281102
67* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23897139
68* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22260124
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21273414
70* PU_27001747_Chip-Seq_BMDM_Mouse1.18897126
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17885180
72GATA3_27048872_Chip-Seq_THYMUS_Human1.17468824
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.16998289
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16113384
75GATA1_22025678_ChIP-Seq_K562_Human1.14931879
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14155786
77KDM2B_26808549_Chip-Seq_K562_Human1.13636835
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13631652
79* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13604290
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12328604
81* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11926279
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.11007239
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10430035
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09376765
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09095366
86* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08030031
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07487040
88RACK7_27058665_Chip-Seq_MCF-7_Human1.06996670
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06904124
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06185005
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06176185
92* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05122776
93* ATF3_27146783_Chip-Seq_COLON_Human1.04933900
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04632373
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04258834
96* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03712687
97GATA1_19941826_ChIP-Seq_K562_Human1.02716727
98* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02671147
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01824743
100* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01348018
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01135848
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01079742
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.00965311
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00944595
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99110467
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98900436
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98900436
108* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98827243
109LXR_22292898_ChIP-Seq_THP-1_Human0.97672395
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97094010
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.96589991
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.96589991
113* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95754918
114GATA2_19941826_ChIP-Seq_K562_Human0.95134297
115TFEB_21752829_ChIP-Seq_HELA_Human0.94334537
116BCOR_27268052_Chip-Seq_Bcells_Human0.92503419
117E2F1_21310950_ChIP-Seq_MCF-7_Human0.91870115
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.91538256
119EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90804882
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88507492
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88372773
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88365781
123* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88343466
124BCL6_27268052_Chip-Seq_Bcells_Human0.87828274
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.87492856
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.86676840
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84354414
128* GATA1_19941827_ChIP-Seq_MEL_Mouse0.84242723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow2.87135240
2MP0003705_abnormal_hypodermis_morpholog2.65733458
3MP0003303_peritoneal_inflammation2.58241176
4MP0004510_myositis2.52256275
5MP0003300_gastrointestinal_ulcer2.36948299
6MP0001835_abnormal_antigen_presentation2.28965072
7MP0008260_abnormal_autophagy2.22628124
8MP0000685_abnormal_immune_system2.18326998
9MP0004808_abnormal_hematopoietic_stem2.17693667
10MP0003436_decreased_susceptibility_to2.17270999
11MP0008438_abnormal_cutaneous_collagen2.14487244
12MP0003566_abnormal_cell_adhesion2.13174696
13MP0002396_abnormal_hematopoietic_system2.10543404
14MP0010352_gastrointestinal_tract_polyps2.05001904
15MP0005451_abnormal_body_composition1.96973319
16MP0002166_altered_tumor_susceptibility1.96436674
17MP0001800_abnormal_humoral_immune1.86277035
18MP0003828_pulmonary_edema1.80695921
19MP0002452_abnormal_antigen_presenting1.77360992
20MP0001545_abnormal_hematopoietic_system1.71268502
21MP0005397_hematopoietic_system_phenotyp1.71268502
22MP0001790_abnormal_immune_system1.69470878
23MP0005387_immune_system_phenotype1.69470878
24MP0005076_abnormal_cell_differentiation1.68703865
25MP0002419_abnormal_innate_immunity1.66924046
26MP0003279_aneurysm1.63813407
27MP0005058_abnormal_lysosome_morphology1.61175341
28MP0005000_abnormal_immune_tolerance1.59708168
29* MP0002420_abnormal_adaptive_immunity1.56852528
30MP0002132_abnormal_respiratory_system1.56557694
31* MP0001819_abnormal_immune_cell1.56551719
32MP0004381_abnormal_hair_follicle1.55889148
33* MP0002723_abnormal_immune_serum1.54372703
34* MP0002398_abnormal_bone_marrow1.51484169
35MP0001873_stomach_inflammation1.50112870
36MP0002405_respiratory_system_inflammati1.49516449
37MP0003191_abnormal_cellular_cholesterol1.49147043
38MP0005464_abnormal_platelet_physiology1.49054165
39MP0005023_abnormal_wound_healing1.48129826
40MP0006082_CNS_inflammation1.47084736
41MP0010307_abnormal_tumor_latency1.47011964
42MP0000767_abnormal_smooth_muscle1.46798855
43MP0004883_abnormal_blood_vessel1.46686058
44MP0003183_abnormal_peptide_metabolism1.45992466
45MP0004947_skin_inflammation1.45438238
46MP0003763_abnormal_thymus_physiology1.44348961
47MP0003091_abnormal_cell_migration1.43117823
48MP0010368_abnormal_lymphatic_system1.41202180
49MP0005671_abnormal_response_to1.37362434
50MP0005025_abnormal_response_to1.37146981
51MP0004185_abnormal_adipocyte_glucose1.37083382
52MP0002006_tumorigenesis1.36876547
53MP0001851_eye_inflammation1.36830948
54MP0001853_heart_inflammation1.36333720
55MP0001533_abnormal_skeleton_physiology1.36120320
56* MP0000689_abnormal_spleen_morphology1.35473874
57* MP0000716_abnormal_immune_system1.32530014
58MP0003448_altered_tumor_morphology1.31179467
59MP0001879_abnormal_lymphatic_vessel1.31164361
60MP0001958_emphysema1.28902135
61MP0010155_abnormal_intestine_physiology1.27883962
62* MP0002722_abnormal_immune_system1.27267528
63MP0002933_joint_inflammation1.26930869
64MP0009785_altered_susceptibility_to1.26634009
65MP0005164_abnormal_response_to1.23760787
66MP0003866_abnormal_defecation1.21856666
67MP0008469_abnormal_protein_level1.21020675
68MP0009333_abnormal_splenocyte_physiolog1.20957532
69MP0006054_spinal_hemorrhage1.20097564
70MP0003075_altered_response_to1.18063588
71MP0000465_gastrointestinal_hemorrhage1.17799295
72MP0004084_abnormal_cardiac_muscle1.17789621
73* MP0002429_abnormal_blood_cell1.17395032
74MP0000733_abnormal_muscle_development1.16254097
75* MP0000703_abnormal_thymus_morphology1.13963265
76MP0005167_abnormal_blood-brain_barrier1.13604929
77MP0002998_abnormal_bone_remodeling1.11996309
78MP0001845_abnormal_inflammatory_respons1.10846608
79MP0000858_altered_metastatic_potential1.07002642
80* MP0010630_abnormal_cardiac_muscle1.06075128
81MP0009764_decreased_sensitivity_to1.04897617
82MP0002148_abnormal_hypersensitivity_rea1.04863669
83MP0010234_abnormal_vibrissa_follicle1.02964385
84MP0005310_abnormal_salivary_gland1.01210590
85MP0000343_altered_response_to1.00724842
86MP0003690_abnormal_glial_cell0.99776292
87MP0002254_reproductive_system_inflammat0.97614590
88MP0002009_preneoplasia0.95939418
89MP0003045_fibrosis0.95774179
90* MP0002925_abnormal_cardiovascular_devel0.92003069
91MP0001915_intracranial_hemorrhage0.90750864
92MP0001849_ear_inflammation0.90035231
93MP0003724_increased_susceptibility_to0.89708505
94MP0008004_abnormal_stomach_pH0.89619662
95MP0003172_abnormal_lysosome_physiology0.89470572
96MP0002877_abnormal_melanocyte_morpholog0.89253685
97MP0000604_amyloidosis0.89149432
98MP0004272_abnormal_basement_membrane0.88696973
99MP0005409_darkened_coat_color0.87339762
100MP0009840_abnormal_foam_cell0.87065029
101MP0005166_decreased_susceptibility_to0.86927262
102MP0003453_abnormal_keratinocyte_physiol0.85422144
103MP0000569_abnormal_digit_pigmentation0.85229766
104MP0002088_abnormal_embryonic_growth/wei0.84727224
105MP0000015_abnormal_ear_pigmentation0.84235396
106MP0000249_abnormal_blood_vessel0.84038348
107* MP0002086_abnormal_extraembryonic_tissu0.83945352
108MP0003077_abnormal_cell_cycle0.83691958
109MP0003567_abnormal_fetal_cardiomyocyte0.83614197
110MP0003984_embryonic_growth_retardation0.83485492
111MP0005666_abnormal_adipose_tissue0.82228010
112MP0000490_abnormal_crypts_of0.81090050
113MP0005390_skeleton_phenotype0.80871493
114MP0002128_abnormal_blood_circulation0.80815618
115MP0004130_abnormal_muscle_cell0.80586196
116MP0002138_abnormal_hepatobiliary_system0.80378020
117MP0008007_abnormal_cellular_replicative0.79991104
118MP0003795_abnormal_bone_structure0.78149834
119MP0005275_abnormal_skin_tensile0.77466464
120MP0002928_abnormal_bile_duct0.76993799
121MP0002332_abnormal_exercise_endurance0.74858581
122MP0009763_increased_sensitivity_to0.72735172
123MP0001663_abnormal_digestive_system0.65279923
124MP0002133_abnormal_respiratory_system0.64076378
125MP0005388_respiratory_system_phenotype0.64076378
126MP0003656_abnormal_erythrocyte_physiolo0.63935925

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.03653244
2Hematochezia (HP:0002573)3.93586702
3Gastrointestinal infarctions (HP:0005244)3.49415549
4Stomatitis (HP:0010280)3.47639809
5Recurrent skin infections (HP:0001581)3.37262349
6Meningitis (HP:0001287)3.21854529
7Spontaneous hematomas (HP:0007420)3.21386566
8Chronic obstructive pulmonary disease (HP:0006510)3.21207086
9Obstructive lung disease (HP:0006536)3.21207086
10Chronic mucocutaneous candidiasis (HP:0002728)3.16065433
11Recurrent cutaneous fungal infections (HP:0011370)3.16065433
12Increased IgE level (HP:0003212)3.08042205
13Eczematoid dermatitis (HP:0000976)3.06861763
14Recurrent abscess formation (HP:0002722)3.06400180
15Aortic aneurysm (HP:0004942)3.00185228
16Keratoconjunctivitis sicca (HP:0001097)2.89027221
17Abnormality of the fingertips (HP:0001211)2.81348212
18Vasculitis (HP:0002633)2.77703534
19Urticaria (HP:0001025)2.75754410
20Myositis (HP:0100614)2.75129211
21Encephalitis (HP:0002383)2.71076877
22Hemoptysis (HP:0002105)2.67520533
23Epistaxis (HP:0000421)2.66722863
24Cellulitis (HP:0100658)2.65947805
25Gingival bleeding (HP:0000225)2.63442320
26Osteolytic defects of the hand bones (HP:0009699)2.61326270
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.61326270
28Recurrent bacterial skin infections (HP:0005406)2.58199171
29Aortic dissection (HP:0002647)2.57623116
30Keratoconjunctivitis (HP:0001096)2.57519965
31Protrusio acetabuli (HP:0003179)2.53764282
32Amyloidosis (HP:0011034)2.52940836
33Pulmonary embolism (HP:0002204)2.49734730
34Increased density of long bones (HP:0006392)2.48730593
35Mitral valve prolapse (HP:0001634)2.47987200
36Pulmonary infiltrates (HP:0002113)2.46657726
37Thrombocytosis (HP:0001894)2.46605486
38Elevated erythrocyte sedimentation rate (HP:0003565)2.43880071
39Striae distensae (HP:0001065)2.43495804
40Premature rupture of membranes (HP:0001788)2.39718418
41Spondylolisthesis (HP:0003302)2.36393453
42Abnormality of liposaccharide metabolism (HP:0010968)2.36108897
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.36108897
44Abnormality of glycolipid metabolism (HP:0010969)2.36108897
45Bicuspid aortic valve (HP:0001647)2.34809205
46Hypochromic microcytic anemia (HP:0004840)2.33620832
47Episodic fever (HP:0001954)2.32139985
48Recurrent viral infections (HP:0004429)2.30584881
49Arterial thrombosis (HP:0004420)2.30460528
50Hypochromic anemia (HP:0001931)2.28114569
51Myocardial infarction (HP:0001658)2.26885205
52Recurrent fungal infections (HP:0002841)2.25966948
53Colitis (HP:0002583)2.24605009
54Systemic lupus erythematosus (HP:0002725)2.24598652
55Anorexia (HP:0002039)2.23334476
56Increased connective tissue (HP:0009025)2.21707548
57Orchitis (HP:0100796)2.20655272
58Dilatation of the ascending aorta (HP:0005111)2.20643848
59Abnormality of the nasal mucosa (HP:0000433)2.20445618
60Panhypogammaglobulinemia (HP:0003139)2.20008527
61Ankle contracture (HP:0006466)2.18331833
62Loss of speech (HP:0002371)2.17513562
63Interstitial pulmonary disease (HP:0006530)2.16796367
64Persistence of primary teeth (HP:0006335)2.15626177
65Petechiae (HP:0000967)2.14124936
66Aneurysm (HP:0002617)2.13007777
67Abnormal platelet volume (HP:0011876)2.12782892
68Spinal cord lesions (HP:0100561)2.12720065
69Syringomyelia (HP:0003396)2.12720065
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12433376
71Chronic otitis media (HP:0000389)2.12334094
72Shallow orbits (HP:0000586)2.12059141
73Asymmetric septal hypertrophy (HP:0001670)2.10487535
74Peritonitis (HP:0002586)2.10481555
75Gastrointestinal inflammation (HP:0004386)2.10102941
76Granulocytopenia (HP:0001913)2.10057830
77Inflammation of the large intestine (HP:0002037)2.09506673
78Absent frontal sinuses (HP:0002688)2.09258176
79Microcytic anemia (HP:0001935)2.07761044
80Purpura (HP:0000979)2.07645847
81Slow saccadic eye movements (HP:0000514)2.05937771
82Arterial tortuosity (HP:0005116)2.02347377
83Abnormality of T cells (HP:0002843)2.00608325
84Polycythemia (HP:0001901)1.99236766
85Cervical subluxation (HP:0003308)1.98874789
86Viral hepatitis (HP:0006562)1.98729556
87Ulnar bowing (HP:0003031)1.98642787
88Increased cerebral lipofuscin (HP:0011813)1.98110215
89Rectal prolapse (HP:0002035)1.97938239
90Periodontitis (HP:0000704)1.94589763
91Abnormality of the endocardium (HP:0004306)1.93714723
92Increased mean platelet volume (HP:0011877)1.90511019
93Abnormality of macrophages (HP:0004311)1.90098455
94Recurrent gram-negative bacterial infections (HP:0005420)1.89118979
95IgM deficiency (HP:0002850)1.88793258
96Sepsis (HP:0100806)1.88331565
97Polygenic inheritance (HP:0010982)1.87254678
98Papilloma (HP:0012740)1.87067778
99Verrucae (HP:0200043)1.87067778
100Abnormality of polysaccharide metabolism (HP:0011012)1.86057855
101Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86057855
102Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86057855
103Glomerulopathy (HP:0100820)1.85183284
104Hyperacusis (HP:0010780)1.84859536
105Chest pain (HP:0100749)1.84520907
106Hypergammaglobulinemia (HP:0010702)1.84335884
107Vascular tortuosity (HP:0004948)1.83508945
108High pitched voice (HP:0001620)1.82055840
109Urinary glycosaminoglycan excretion (HP:0003541)1.80760003
110Mucopolysacchariduria (HP:0008155)1.80760003
111Abnormality of the pleura (HP:0002103)1.80732280
112Disproportionate tall stature (HP:0001519)1.80553445
113Autoimmune thrombocytopenia (HP:0001973)1.80326418
114Entropion (HP:0000621)1.78638834
115Increased variability in muscle fiber diameter (HP:0003557)1.78440436
116Abnormality of the peritoneum (HP:0002585)1.78274153
117Skin ulcer (HP:0200042)1.78067354
118Lymphopenia (HP:0001888)1.77377143
119Fatigue (HP:0012378)1.77039304
120Pustule (HP:0200039)1.76808881
121Broad metatarsal (HP:0001783)1.76687650
122Nasal polyposis (HP:0100582)1.76543369
123Emphysema (HP:0002097)1.75996353
124Spinal muscular atrophy (HP:0007269)1.75697003
125Hepatosplenomegaly (HP:0001433)1.74880734
126Dysostosis multiplex (HP:0000943)1.74185010
127Abnormality of skeletal muscle fiber size (HP:0012084)1.73756446
128Restrictive lung disease (HP:0002091)1.73599913
129T lymphocytopenia (HP:0005403)1.73489478
130Mediastinal lymphadenopathy (HP:0100721)1.73482459
131Agammaglobulinemia (HP:0004432)1.73122568
132Recurrent bronchitis (HP:0002837)1.73065486
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71530760
134Short 4th metacarpal (HP:0010044)1.71530760
135Osteomyelitis (HP:0002754)1.71458542
136Frequent falls (HP:0002359)1.71402860
137Long eyelashes (HP:0000527)1.70924867
138Enlarged penis (HP:0000040)1.70865733
139Subacute progressive viral hepatitis (HP:0006572)1.69966264
140Mucosal telangiectasiae (HP:0100579)1.68854977
141Asymmetry of the thorax (HP:0001555)1.67836992
142Radial bowing (HP:0002986)1.66950826
143Coarse hair (HP:0002208)1.66402569
144Abnormality of T cell number (HP:0011839)1.66030117
145Abnormality of the lumbar spine (HP:0100712)1.64742504
146Thoracic kyphosis (HP:0002942)1.64523651
147Abnormal delayed hypersensitivity skin test (HP:0002963)1.64491360
148Optic neuritis (HP:0100653)1.63102976
149Retrobulbar optic neuritis (HP:0100654)1.63102976
150Conjunctival telangiectasia (HP:0000524)1.61486043
151Camptodactyly of toe (HP:0001836)1.60457090
152Esophageal varix (HP:0002040)1.59714108
153Gingivitis (HP:0000230)1.59405105
154Prolonged bleeding time (HP:0003010)1.58919033
155Leukocytosis (HP:0001974)1.57259060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.93102004
2MAP4K13.18539900
3PKN23.17514756
4PRPF4B3.12829745
5EEF2K3.10573059
6TTN3.06382896
7TGFBR23.01735541
8ERN12.37210829
9MAP3K102.28574486
10FES2.26421394
11STK102.20989417
12CDK122.14929531
13TYK22.02742371
14KIT2.00078443
15JAK31.80178651
16TNK21.78218086
17CSF1R1.75504371
18PTK61.66062603
19LRRK21.58231673
20FGFR31.55772801
21TIE11.53846481
22ZAP701.50308880
23FGR1.48935875
24SMG11.47200676
25MAP3K141.46866904
26RIPK11.45789170
27ITK1.44179888
28EPHB11.43540189
29MAP3K11.41674408
30TAOK11.41271391
31TBK11.40893730
32FLT31.39013781
33FGFR41.36680908
34CAMK1D1.35406743
35MAP3K111.34810028
36RPS6KA41.31906229
37JAK11.31743923
38BTK1.29611860
39PAK41.29221696
40KSR21.25689841
41MARK21.25546770
42TRPM71.23966440
43HCK1.22881433
44CSK1.20454072
45GRK61.19223212
46TGFBR11.15792180
47NEK21.11251523
48KDR1.10852961
49SIK31.10804439
50MAP3K61.08254863
51BLK1.06078507
52IKBKB1.05543200
53SIK11.04849578
54CDK41.01671456
55CDK60.99798299
56YES10.98380132
57PIM10.98292476
58CDC42BPA0.98244951
59PDPK10.97953168
60IRAK10.97208557
61TAOK30.96243003
62MARK30.93803214
63IRAK20.92383703
64TEC0.92340843
65TAOK20.91332112
66DMPK0.90557078
67PRKCH0.90021966
68PDGFRA0.89984352
69CAMK1G0.89290324
70CHUK0.88934988
71MAPK70.86426374
72NEK90.86413476
73STK40.84222035
74MTOR0.83914001
75MAP3K80.82480978
76IKBKE0.81345958
77LCK0.80960667
78STK30.79735572
79ICK0.79727525
80JAK20.79450797
81RPS6KB20.78210286
82SCYL20.77807251
83BRD40.76692629
84PAK20.76133882
85SYK0.75930132
86HIPK20.75629600
87IRAK40.74128646
88SIK20.72109085
89CLK10.70541287
90PRKD20.69877179
91PDGFRB0.69771655
92PIK3CG0.67837142
93ALK0.67444983
94TXK0.66262271
95STK380.65559593
96MELK0.60259545
97CDK90.59085984
98MAP3K20.58710234
99DYRK1B0.57773649
100MAPKAPK30.57768725
101MATK0.57652191
102MAP3K70.57075775
103RIPK40.56604585
104RPS6KA20.55612629
105MAP3K130.53917150
106FYN0.53473254
107EPHA30.53354298
108PTK20.52679863
109* MAP2K30.52597048
110NLK0.51615889
111PRKAA20.50942279
112BMX0.48583911
113RPS6KA60.47672085
114LATS10.46644818
115EGFR0.46461013
116PRKD10.44591988
117TSSK60.44521769
118ILK0.43716049
119BMPR20.43594394
120CAMKK10.43294798
121PDK10.43163774
122RPS6KL10.42550695
123RPS6KC10.42550695
124MAPKAPK20.41113604
125MOS0.41020523
126FGFR10.40698677
127PRKG20.40295773
128MAP3K50.39656801
129STK110.38522118
130LYN0.37879972
131PASK0.37789340
132IRAK30.37741937
133PTK2B0.36608267
134MAPK120.34429182
135MAPK110.33916526
136RET0.33708000
137ABL10.33397673
138STK240.33319940

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.30179636
2Osteoclast differentiation_Homo sapiens_hsa043802.25253675
3Leishmaniasis_Homo sapiens_hsa051402.20647731
4Chronic myeloid leukemia_Homo sapiens_hsa052201.93492276
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.78855982
6Leukocyte transendothelial migration_Homo sapiens_hsa046701.75216382
7Graft-versus-host disease_Homo sapiens_hsa053321.74382448
8Toxoplasmosis_Homo sapiens_hsa051451.72909591
9Allograft rejection_Homo sapiens_hsa053301.70942081
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69850745
11Staphylococcus aureus infection_Homo sapiens_hsa051501.69514849
12Small cell lung cancer_Homo sapiens_hsa052221.65622285
13Measles_Homo sapiens_hsa051621.59258143
14Autoimmune thyroid disease_Homo sapiens_hsa053201.59244580
15Acute myeloid leukemia_Homo sapiens_hsa052211.56366547
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55173218
17Viral myocarditis_Homo sapiens_hsa054161.54706256
18Antigen processing and presentation_Homo sapiens_hsa046121.51512693
19Primary immunodeficiency_Homo sapiens_hsa053401.48545078
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.47939231
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47115890
22Pancreatic cancer_Homo sapiens_hsa052121.44258373
23Shigellosis_Homo sapiens_hsa051311.43920285
24Platelet activation_Homo sapiens_hsa046111.43385401
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43172925
26Focal adhesion_Homo sapiens_hsa045101.42704998
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39269083
28T cell receptor signaling pathway_Homo sapiens_hsa046601.35693557
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34439202
30Hepatitis B_Homo sapiens_hsa051611.34088160
31Apoptosis_Homo sapiens_hsa042101.31205426
32TNF signaling pathway_Homo sapiens_hsa046681.26535001
33Proteoglycans in cancer_Homo sapiens_hsa052051.25178611
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24302495
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23996874
36Hematopoietic cell lineage_Homo sapiens_hsa046401.22624159
37Herpes simplex infection_Homo sapiens_hsa051681.20595136
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.19840760
39Influenza A_Homo sapiens_hsa051641.18481850
40Phagosome_Homo sapiens_hsa041451.18060757
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17929350
42Insulin resistance_Homo sapiens_hsa049311.17234615
43Adherens junction_Homo sapiens_hsa045201.17157456
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17038717
45MicroRNAs in cancer_Homo sapiens_hsa052061.15872930
46Non-small cell lung cancer_Homo sapiens_hsa052231.14325493
47Tuberculosis_Homo sapiens_hsa051521.14184965
48Legionellosis_Homo sapiens_hsa051341.14182899
49Pertussis_Homo sapiens_hsa051331.12027548
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11779693
51VEGF signaling pathway_Homo sapiens_hsa043701.10746305
52Chemokine signaling pathway_Homo sapiens_hsa040621.10566694
53Type I diabetes mellitus_Homo sapiens_hsa049401.10393899
54mTOR signaling pathway_Homo sapiens_hsa041501.09319764
55* Neurotrophin signaling pathway_Homo sapiens_hsa047221.08939615
56Viral carcinogenesis_Homo sapiens_hsa052031.06802802
57* HTLV-I infection_Homo sapiens_hsa051661.06548126
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04391173
59ECM-receptor interaction_Homo sapiens_hsa045121.03685938
60Amoebiasis_Homo sapiens_hsa051461.01355002
61Notch signaling pathway_Homo sapiens_hsa043300.99962036
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.99728384
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99093800
64Other glycan degradation_Homo sapiens_hsa005110.99067400
65Lysosome_Homo sapiens_hsa041420.95645440
66Malaria_Homo sapiens_hsa051440.94852824
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.94687381
68HIF-1 signaling pathway_Homo sapiens_hsa040660.93131532
69Prolactin signaling pathway_Homo sapiens_hsa049170.89014105
70Salmonella infection_Homo sapiens_hsa051320.87331971
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.87290729
72African trypanosomiasis_Homo sapiens_hsa051430.87133373
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85805248
74Colorectal cancer_Homo sapiens_hsa052100.85484577
75Renal cell carcinoma_Homo sapiens_hsa052110.85108455
76FoxO signaling pathway_Homo sapiens_hsa040680.84987187
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.84448199
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84326658
79Epstein-Barr virus infection_Homo sapiens_hsa051690.84114976
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82496343
81Lysine degradation_Homo sapiens_hsa003100.80851993
82p53 signaling pathway_Homo sapiens_hsa041150.80555292
83Prostate cancer_Homo sapiens_hsa052150.77542045
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77460283
85Choline metabolism in cancer_Homo sapiens_hsa052310.77403481
86Asthma_Homo sapiens_hsa053100.77012000
87Hepatitis C_Homo sapiens_hsa051600.75323134
88* GnRH signaling pathway_Homo sapiens_hsa049120.74925896
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74129301
90Caffeine metabolism_Homo sapiens_hsa002320.73726857
91Dilated cardiomyopathy_Homo sapiens_hsa054140.73520935
92Rheumatoid arthritis_Homo sapiens_hsa053230.73088680
93Pathways in cancer_Homo sapiens_hsa052000.72632868
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72540387
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.71536517
96Rap1 signaling pathway_Homo sapiens_hsa040150.68909084
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68774170
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68390380
99Endometrial cancer_Homo sapiens_hsa052130.68348416
100Cell cycle_Homo sapiens_hsa041100.67454256
101Glioma_Homo sapiens_hsa052140.64906211
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64071375
103ErbB signaling pathway_Homo sapiens_hsa040120.63480020
104Dorso-ventral axis formation_Homo sapiens_hsa043200.62788564
105Thyroid cancer_Homo sapiens_hsa052160.62427739
106Inositol phosphate metabolism_Homo sapiens_hsa005620.61556206
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59046699
108Bladder cancer_Homo sapiens_hsa052190.58833056
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58452279
110Systemic lupus erythematosus_Homo sapiens_hsa053220.58332949
111Insulin signaling pathway_Homo sapiens_hsa049100.58279930
112Estrogen signaling pathway_Homo sapiens_hsa049150.56746207
113Endocytosis_Homo sapiens_hsa041440.56625128
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55175590
115Type II diabetes mellitus_Homo sapiens_hsa049300.54830627
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53405172
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53283078
118TGF-beta signaling pathway_Homo sapiens_hsa043500.53158319
119* MAPK signaling pathway_Homo sapiens_hsa040100.53116099
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51938972

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