MAP3K5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.02646334
2regulation of B cell receptor signaling pathway (GO:0050855)4.71429826
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.65410319
4negative regulation of cell killing (GO:0031342)4.65410319
5macrophage activation involved in immune response (GO:0002281)4.24165342
6detection of external biotic stimulus (GO:0098581)4.12516648
7valine metabolic process (GO:0006573)4.08211796
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.03220619
9L-phenylalanine catabolic process (GO:0006559)4.03220619
10urea cycle (GO:0000050)4.00487551
11urea metabolic process (GO:0019627)4.00487551
12aromatic amino acid family catabolic process (GO:0009074)3.95739841
13positive regulation of gamma-delta T cell activation (GO:0046645)3.93130608
14cellular extravasation (GO:0045123)3.92731697
15detection of other organism (GO:0098543)3.88703282
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.88398681
17tryptophan catabolic process (GO:0006569)3.86688435
18indole-containing compound catabolic process (GO:0042436)3.86688435
19indolalkylamine catabolic process (GO:0046218)3.86688435
20B cell receptor signaling pathway (GO:0050853)3.80563906
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.80036351
22L-phenylalanine metabolic process (GO:0006558)3.80036351
23complement activation, alternative pathway (GO:0006957)3.77793568
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.76590365
25lysine metabolic process (GO:0006553)3.74216918
26lysine catabolic process (GO:0006554)3.74216918
27kynurenine metabolic process (GO:0070189)3.73102923
28neutrophil activation involved in immune response (GO:0002283)3.70800397
29response to peptidoglycan (GO:0032494)3.70296395
30tryptophan metabolic process (GO:0006568)3.69884225
31glucocorticoid biosynthetic process (GO:0006704)3.68925829
32microglial cell activation (GO:0001774)3.67433024
33phospholipid homeostasis (GO:0055091)3.63777677
34peptidyl-glutamic acid carboxylation (GO:0017187)3.55144293
35protein carboxylation (GO:0018214)3.55144293
36nitrogen cycle metabolic process (GO:0071941)3.54903312
37detection of bacterium (GO:0016045)3.54674715
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53312261
39detection of biotic stimulus (GO:0009595)3.53019513
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51411374
41response to host immune response (GO:0052572)3.51411374
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.49940825
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49094936
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49094936
45antigen processing and presentation of endogenous antigen (GO:0019883)3.40834119
462-oxoglutarate metabolic process (GO:0006103)3.40536558
47negative regulation of interleukin-12 production (GO:0032695)3.40278778
48response to host (GO:0075136)3.37461470
49response to host defenses (GO:0052200)3.37461470
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37461470
51immunoglobulin mediated immune response (GO:0016064)3.37320901
52alpha-linolenic acid metabolic process (GO:0036109)3.36009086
53dicarboxylic acid biosynthetic process (GO:0043650)3.35395531
54negative regulation of erythrocyte differentiation (GO:0045647)3.34705899
55bile acid biosynthetic process (GO:0006699)3.31489683
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.30597480
57macrophage activation (GO:0042116)3.25845172
58regulation of protein activation cascade (GO:2000257)3.25005590
59cysteine metabolic process (GO:0006534)3.24987162
60homocysteine metabolic process (GO:0050667)3.22794280
61germinal center formation (GO:0002467)3.22443272
62glucocorticoid metabolic process (GO:0008211)3.21306104
63negative thymic T cell selection (GO:0045060)3.20101996
64sulfur amino acid catabolic process (GO:0000098)3.18207557
65response to interleukin-15 (GO:0070672)3.16656061
66regulation of gamma-delta T cell activation (GO:0046643)3.16083385
67regulation of triglyceride catabolic process (GO:0010896)3.15502515
68fatty acid transmembrane transport (GO:1902001)3.15273365
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15139903
70positive thymic T cell selection (GO:0045059)3.14960927
71interferon-gamma-mediated signaling pathway (GO:0060333)3.12577513
72type I interferon signaling pathway (GO:0060337)3.11292479
73cellular response to type I interferon (GO:0071357)3.11292479
74response to type I interferon (GO:0034340)3.10111161
75regulation of gamma-delta T cell differentiation (GO:0045586)3.09950709
76negative regulation of lymphocyte mediated immunity (GO:0002707)3.09745346
77regulation of complement activation (GO:0030449)3.08362221
78positive regulation of lipid catabolic process (GO:0050996)3.07552436
79amino-acid betaine metabolic process (GO:0006577)3.07544676
80negative T cell selection (GO:0043383)3.06775004
81regulation of cholesterol homeostasis (GO:2000188)3.06551920
82myeloid cell activation involved in immune response (GO:0002275)3.03882404
83regulation of B cell differentiation (GO:0045577)3.03208284
84negative regulation of T cell mediated immunity (GO:0002710)3.02672901
85phospholipid efflux (GO:0033700)3.01767329
86oxaloacetate metabolic process (GO:0006107)3.00896573
87glyoxylate metabolic process (GO:0046487)3.00223653
88lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96527562
89negative regulation of T-helper cell differentiation (GO:0045623)2.95400562
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95400562
91positive regulation of interferon-alpha production (GO:0032727)2.94969673
92regulation of sequestering of triglyceride (GO:0010889)2.94099607
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92817713
94regulation of T-helper 2 cell differentiation (GO:0045628)2.92729239
95bile acid metabolic process (GO:0008206)2.91384655
96T cell migration (GO:0072678)2.91156055
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90355187
98leukocyte aggregation (GO:0070486)2.89937636
99negative regulation of leukocyte mediated immunity (GO:0002704)2.89281764
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89164417
101high-density lipoprotein particle remodeling (GO:0034375)2.87865532
102response to muramyl dipeptide (GO:0032495)2.86939536
103fatty acid beta-oxidation (GO:0006635)2.86401335
104positive regulation of macrophage cytokine production (GO:0060907)2.85686121
105carnitine shuttle (GO:0006853)2.83977371
106positive regulation of fatty acid beta-oxidation (GO:0032000)2.83820162
107regulation of alpha-beta T cell proliferation (GO:0046640)2.83726112
108cellular response to epinephrine stimulus (GO:0071872)2.83481916
109plasma lipoprotein particle clearance (GO:0034381)2.82413428
110neutrophil activation (GO:0042119)2.82082957
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80545152
112regulation of interferon-alpha production (GO:0032647)2.79785606
113acylglycerol homeostasis (GO:0055090)2.77585586
114triglyceride homeostasis (GO:0070328)2.77585586
115regulation of macrophage cytokine production (GO:0010935)2.77424963
116T-helper 1 type immune response (GO:0042088)2.75154035
117fatty acid oxidation (GO:0019395)2.74713517
118regulation of cholesterol storage (GO:0010885)2.74556066
119B cell mediated immunity (GO:0019724)2.72418350
120cellular response to interleukin-15 (GO:0071350)2.72289650
121regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.71862382
122positive regulation of cellular amide metabolic process (GO:0034250)2.71828172
123cellular glucuronidation (GO:0052695)2.71775492
124positive regulation of mast cell activation (GO:0033005)2.71646277
125aromatic amino acid family metabolic process (GO:0009072)2.71063961
126benzene-containing compound metabolic process (GO:0042537)2.70992606
127serine family amino acid catabolic process (GO:0009071)2.70572743
128positive T cell selection (GO:0043368)2.70172974
129lipid oxidation (GO:0034440)2.70145090
130regulation of T-helper 1 cell differentiation (GO:0045625)2.69471655
131indolalkylamine metabolic process (GO:0006586)2.68901876
132negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.67180828
133positive regulation by symbiont of host defense response (GO:0052509)2.66953803
134modulation by symbiont of host defense response (GO:0052031)2.66953803
135modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.66953803
136modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.66953803
137positive regulation by organism of defense response of other organism involved in symbiotic interact2.66953803
138modulation by symbiont of host immune response (GO:0052553)2.66953803
139regulation of mast cell degranulation (GO:0043304)2.66876581
140complement activation, classical pathway (GO:0006958)2.66643643
141drug catabolic process (GO:0042737)2.66060034
142reverse cholesterol transport (GO:0043691)2.65318857
143negative regulation of sterol transport (GO:0032372)2.64985109
144negative regulation of cholesterol transport (GO:0032375)2.64985109
145granulocyte activation (GO:0036230)2.64852479
146defense response to protozoan (GO:0042832)2.64304476
147regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63275282
148JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62423618
149positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.62346729
150negative regulation of lipid storage (GO:0010888)2.62139069
151T cell selection (GO:0045058)2.61898954
152tricarboxylic acid metabolic process (GO:0072350)2.60024154
153positive regulation of fatty acid oxidation (GO:0046321)2.60004699
154acetyl-CoA metabolic process (GO:0006084)2.59895858
155production of molecular mediator involved in inflammatory response (GO:0002532)2.59477962
156low-density lipoprotein particle clearance (GO:0034383)2.59029782
157complement activation (GO:0006956)2.58697765
158cellular ketone body metabolic process (GO:0046950)2.58587852
159regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58444273
160alpha-amino acid catabolic process (GO:1901606)2.58099879
161acute-phase response (GO:0006953)2.57608529
162neutrophil mediated immunity (GO:0002446)2.57604117
163negative regulation of type 2 immune response (GO:0002829)2.57443303
164positive regulation of B cell differentiation (GO:0045579)2.57416112
165regulation of fatty acid beta-oxidation (GO:0031998)2.55703536
166fatty acid catabolic process (GO:0009062)2.55239410
167bile acid and bile salt transport (GO:0015721)2.55219663
168negative regulation of fibrinolysis (GO:0051918)2.54939232
169positive regulation of Rap GTPase activity (GO:0032854)2.53924445
170regulation of platelet aggregation (GO:0090330)2.53815885
171plasma lipoprotein particle remodeling (GO:0034369)2.53446305
172protein-lipid complex remodeling (GO:0034368)2.53446305
173macromolecular complex remodeling (GO:0034367)2.53446305
174cellular modified amino acid catabolic process (GO:0042219)2.53184254
175thymic T cell selection (GO:0045061)2.52394866
176ethanol oxidation (GO:0006069)2.52138412
177response to protozoan (GO:0001562)2.52084259
178respiratory burst (GO:0045730)2.52023912
179regulation of interferon-beta biosynthetic process (GO:0045357)2.51660006
180plasma lipoprotein particle assembly (GO:0034377)2.51641071
181tyrosine metabolic process (GO:0006570)2.51514791
182antigen processing and presentation via MHC class Ib (GO:0002475)2.51382460
183negative regulation of interleukin-17 production (GO:0032700)2.50962430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.67946366
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.42516795
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.09528201
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.88688369
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.78017247
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47101891
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10869756
8GATA1_22025678_ChIP-Seq_K562_Human3.07267075
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.01008946
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.00008922
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.76917007
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64570691
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.49371454
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39142431
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35389253
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32070980
17* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29596687
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.26292385
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10501766
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07951629
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96756214
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92832784
23SPI1_23547873_ChIP-Seq_NB4_Human1.84031173
24RUNX_20019798_ChIP-Seq_JUKART_Human1.82206989
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79986377
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.76830773
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75622686
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74666472
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73269167
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70608786
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69856082
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66175919
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64502196
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.63158281
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61504733
36* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58624425
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.58077938
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57138599
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.56824705
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.48895230
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40323857
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40151576
43CLOCK_20551151_ChIP-Seq_293T_Human1.36986945
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34014630
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33005907
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26564508
47* SPI1_23127762_ChIP-Seq_K562_Human1.25144183
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.24906782
49* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24531453
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24091780
51* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23007734
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21346939
53MYB_26560356_Chip-Seq_TH2_Human1.21261932
54TCF7_22412390_ChIP-Seq_EML_Mouse1.21058249
55* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17948354
56VDR_24787735_ChIP-Seq_THP-1_Human1.17804572
57* MYB_26560356_Chip-Seq_TH1_Human1.17669815
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.15482794
59* GATA2_19941826_ChIP-Seq_K562_Human1.12491796
60MAF_26560356_Chip-Seq_TH1_Human1.11577648
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.07079843
62* TBX20_22080862_ChIP-Seq_HEART_Mouse1.06530010
63* TBX20_22328084_ChIP-Seq_HEART_Mouse1.06530010
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06006541
65* GATA3_27048872_Chip-Seq_THYMUS_Human1.05004356
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03053035
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02798817
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02216637
69* PU_27001747_Chip-Seq_BMDM_Mouse1.02181028
70* MAF_26560356_Chip-Seq_TH2_Human1.01422130
71* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00976873
72HNF4A_19822575_ChIP-Seq_HepG2_Human0.99563607
73* GATA1_19941827_ChIP-Seq_MEL_Mouse0.99377449
74* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99327534
75ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99237409
76* SCL_19346495_ChIP-Seq_HPC-7_Human0.99120486
77GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98379999
78* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97991647
79ESR1_20079471_ChIP-ChIP_T-47D_Human0.97083799
80SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96643202
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95075713
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94981348
83* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94072717
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93452130
85* GATA3_26560356_Chip-Seq_TH2_Human0.93272615
86* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92713982
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92547968
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92525253
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.91397346
90VDR_24763502_ChIP-Seq_THP-1_Human0.91248693
91GATA1_19941826_ChIP-Seq_K562_Human0.90665971
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90473946
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90252987
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88580650
95MYC_22102868_ChIP-Seq_BL_Human0.88235383
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87852239
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87191089
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84280094
99* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83974612
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83382901
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83213769
102* UTX_26944678_Chip-Seq_JUKART_Human0.83156788
103ELK3_25401928_ChIP-Seq_HUVEC_Human0.82395383
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81791476
105GATA4_25053715_ChIP-Seq_YYC3_Human0.81703049
106SMRT_27268052_Chip-Seq_Bcells_Human0.81414681
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81190893
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81001164
109* VDR_21846776_ChIP-Seq_THP-1_Human0.80512201
110VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80437593
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80146814
112RUNX1_22412390_ChIP-Seq_EML_Mouse0.79253945
113RXR_22108803_ChIP-Seq_LS180_Human0.78560755
114* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77713116
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77503865
116* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76716127
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76334442
118* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76144195
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75243727
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75018114
121IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74439548
122KDM2B_26808549_Chip-Seq_DND41_Human0.73813424
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73589216
124AHR_22903824_ChIP-Seq_MCF-7_Human0.73197509
125GATA3_26560356_Chip-Seq_TH1_Human0.73091285
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72572293
127EGR1_19032775_ChIP-ChIP_M12_Human0.71182695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.62200336
2MP0005360_urolithiasis4.37591866
3MP0005365_abnormal_bile_salt3.84329152
4MP0005085_abnormal_gallbladder_physiolo3.62277639
5MP0008875_abnormal_xenobiotic_pharmacok2.87899602
6MP0008004_abnormal_stomach_pH2.70568393
7MP0003252_abnormal_bile_duct2.50929768
8MP0003763_abnormal_thymus_physiology2.49017535
9MP0004510_myositis2.45643179
10MP0002138_abnormal_hepatobiliary_system2.35780220
11MP0003191_abnormal_cellular_cholesterol2.33098514
12MP0003303_peritoneal_inflammation2.32923392
13MP0001835_abnormal_antigen_presentation2.31966881
14MP0010329_abnormal_lipoprotein_level2.31178200
15MP0009840_abnormal_foam_cell2.17585492
16MP0003436_decreased_susceptibility_to2.12128302
17MP0003300_gastrointestinal_ulcer2.03971122
18MP0005387_immune_system_phenotype1.92169336
19MP0001790_abnormal_immune_system1.92169336
20MP0000609_abnormal_liver_physiology1.82037600
21MP0003195_calcinosis1.80630379
22MP0002837_dystrophic_cardiac_calcinosis1.78262785
23MP0005332_abnormal_amino_acid1.77620871
24MP0003828_pulmonary_edema1.77303912
25MP0000465_gastrointestinal_hemorrhage1.76840971
26MP0003646_muscle_fatigue1.73751635
27MP0001800_abnormal_humoral_immune1.73133496
28MP0008260_abnormal_autophagy1.71340807
29MP0004130_abnormal_muscle_cell1.69282415
30MP0000685_abnormal_immune_system1.66111490
31MP0002254_reproductive_system_inflammat1.59954711
32MP0002419_abnormal_innate_immunity1.58740321
33MP0004883_abnormal_blood_vessel1.56115707
34MP0002118_abnormal_lipid_homeostasis1.55341801
35MP0001666_abnormal_nutrient_absorption1.49550872
36MP0005464_abnormal_platelet_physiology1.49201229
37MP0002998_abnormal_bone_remodeling1.48182710
38MP0003690_abnormal_glial_cell1.47880925
39MP0005319_abnormal_enzyme/_coenzyme1.47776160
40MP0002166_altered_tumor_susceptibility1.47092282
41MP0001853_heart_inflammation1.45231482
42MP0009764_decreased_sensitivity_to1.42953286
43MP0002452_abnormal_antigen_presenting1.41882637
44MP0005000_abnormal_immune_tolerance1.41455358
45MP0005670_abnormal_white_adipose1.41229242
46MP0005083_abnormal_biliary_tract1.41003134
47MP0002722_abnormal_immune_system1.39735099
48MP0003724_increased_susceptibility_to1.38461032
49MP0009785_altered_susceptibility_to1.37965209
50MP0005058_abnormal_lysosome_morphology1.37755820
51MP0001851_eye_inflammation1.36879712
52MP0001845_abnormal_inflammatory_respons1.35691358
53MP0009643_abnormal_urine_homeostasis1.35043925
54MP0008469_abnormal_protein_level1.34500483
55MP0002429_abnormal_blood_cell1.34219843
56MP0005025_abnormal_response_to1.33427822
57MP0002723_abnormal_immune_serum1.33185290
58MP0003866_abnormal_defecation1.29556823
59MP0003091_abnormal_cell_migration1.28703763
60MP0003656_abnormal_erythrocyte_physiolo1.27787903
61MP0009278_abnormal_bone_marrow1.27499269
62MP0005671_abnormal_response_to1.26852361
63MP0000858_altered_metastatic_potential1.26535915
64MP0004947_skin_inflammation1.25774745
65MP0005164_abnormal_response_to1.25619162
66MP0008961_abnormal_basal_metabolism1.24768981
67MP0009333_abnormal_splenocyte_physiolog1.24543965
68MP0002396_abnormal_hematopoietic_system1.23263024
69MP0002006_tumorigenesis1.22758151
70MP0006082_CNS_inflammation1.22312528
71MP0004019_abnormal_vitamin_homeostasis1.22156590
72MP0005584_abnormal_enzyme/coenzyme_acti1.19543827
73MP0000703_abnormal_thymus_morphology1.18422369
74MP0004808_abnormal_hematopoietic_stem1.15913281
75MP0001819_abnormal_immune_cell1.14596372
76MP0003868_abnormal_feces_composition1.14566719
77MP0002420_abnormal_adaptive_immunity1.14542558
78MP0001873_stomach_inflammation1.14261042
79MP0005666_abnormal_adipose_tissue1.12145284
80MP0000569_abnormal_digit_pigmentation1.10864630
81MP0003075_altered_response_to1.09705342
82MP0010155_abnormal_intestine_physiology1.09248187
83MP0005535_abnormal_body_temperature1.05923410
84MP0003183_abnormal_peptide_metabolism1.05833163
85MP0002136_abnormal_kidney_physiology1.05486669
86MP0009763_increased_sensitivity_to1.05422827
87MP0002009_preneoplasia1.05035060
88MP0003806_abnormal_nucleotide_metabolis1.03878117
89MP0001764_abnormal_homeostasis1.03833960
90MP0010234_abnormal_vibrissa_follicle1.03224126
91MP0004185_abnormal_adipocyte_glucose1.01609002
92MP0000249_abnormal_blood_vessel1.01097880
93MP0002078_abnormal_glucose_homeostasis0.96889884
94MP0003172_abnormal_lysosome_physiology0.96037205
95MP0005451_abnormal_body_composition0.95417092
96MP0005397_hematopoietic_system_phenotyp0.94931872
97MP0001545_abnormal_hematopoietic_system0.94931872
98MP0004381_abnormal_hair_follicle0.93294015
99MP0003448_altered_tumor_morphology0.92586882
100MP0004084_abnormal_cardiac_muscle0.92126602
101MP0000598_abnormal_liver_morphology0.91455173
102MP0001533_abnormal_skeleton_physiology0.90522682
103* MP0005166_decreased_susceptibility_to0.89913062
104MP0005334_abnormal_fat_pad0.89750379
105MP0002332_abnormal_exercise_endurance0.89588001
106MP0002148_abnormal_hypersensitivity_rea0.89577151
107MP0000604_amyloidosis0.89535508
108MP0000716_abnormal_immune_system0.88970605
109MP0005310_abnormal_salivary_gland0.88952708
110MP0002405_respiratory_system_inflammati0.88706091
111MP0002971_abnormal_brown_adipose0.88079528
112MP0003329_amyloid_beta_deposits0.87297382
113MP0005647_abnormal_sex_gland0.86821197
114MP0002928_abnormal_bile_duct0.86126235
115MP0003045_fibrosis0.85975576
116MP0005167_abnormal_blood-brain_barrier0.85489833
117MP0000689_abnormal_spleen_morphology0.84829612
118MP0001756_abnormal_urination0.83553295
119* MP0000343_altered_response_to0.82789688
120MP0002877_abnormal_melanocyte_morpholog0.82637070
121MP0002398_abnormal_bone_marrow0.82509900
122MP0002132_abnormal_respiratory_system0.82301512
123MP0009642_abnormal_blood_homeostasis0.82039979
124* MP0008874_decreased_physiological_sensi0.81673123
125MP0003566_abnormal_cell_adhesion0.80922253
126MP0004036_abnormal_muscle_relaxation0.80236775
127MP0004782_abnormal_surfactant_physiolog0.79801751
128MP0002933_joint_inflammation0.79798138
129MP0003186_abnormal_redox_activity0.79545400
130MP0001765_abnormal_ion_homeostasis0.78228762
131MP0002693_abnormal_pancreas_physiology0.77529313
132MP0000920_abnormal_myelination0.77363113
133MP0008057_abnormal_DNA_replication0.76220716
134MP0003279_aneurysm0.71892626
135MP0000015_abnormal_ear_pigmentation0.70455983
136MP0005076_abnormal_cell_differentiation0.69728956
137MP0005390_skeleton_phenotype0.69214998
138MP0003453_abnormal_keratinocyte_physiol0.65296851
139MP0009115_abnormal_fat_cell0.61730789
140MP0001663_abnormal_digestive_system0.60521487
141MP0005165_increased_susceptibility_to0.59904446
142MP0003795_abnormal_bone_structure0.59100247
143MP0001958_emphysema0.57390769
144MP0009765_abnormal_xenobiotic_induced0.57092598

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.27441250
2Recurrent gram-negative bacterial infections (HP:0005420)4.14587784
3Deep venous thrombosis (HP:0002625)4.09809973
4Orchitis (HP:0100796)4.05787484
5Complement deficiency (HP:0004431)4.05060355
6Retrobulbar optic neuritis (HP:0100654)3.97822077
7Optic neuritis (HP:0100653)3.97822077
8Intrahepatic cholestasis (HP:0001406)3.89402580
9Xanthomatosis (HP:0000991)3.78570578
10Spontaneous hematomas (HP:0007420)3.65210606
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.55057877
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.47832587
13Myocardial infarction (HP:0001658)3.38251610
14Prolonged bleeding time (HP:0003010)3.36524806
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.29308256
16Ketosis (HP:0001946)3.27841765
17Abnormality of the common coagulation pathway (HP:0010990)3.25162138
18Recurrent bacterial skin infections (HP:0005406)3.19924401
19Joint hemorrhage (HP:0005261)3.19269052
20Elevated erythrocyte sedimentation rate (HP:0003565)3.16538558
21Eczematoid dermatitis (HP:0000976)3.16423000
22Prolonged partial thromboplastin time (HP:0003645)3.13206196
23Gastrointestinal infarctions (HP:0005244)3.11394243
24Keratoconjunctivitis sicca (HP:0001097)3.09423433
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09160976
26T lymphocytopenia (HP:0005403)3.05825665
27Hypobetalipoproteinemia (HP:0003563)3.05398170
28Epidermoid cyst (HP:0200040)3.03810973
29Stomatitis (HP:0010280)3.03620851
30Ketoacidosis (HP:0001993)3.02405791
31Abnormality of T cell number (HP:0011839)3.02054857
32Systemic lupus erythematosus (HP:0002725)3.02000048
33Abnormality of complement system (HP:0005339)2.98351319
34Chronic mucocutaneous candidiasis (HP:0002728)2.97826394
35Recurrent cutaneous fungal infections (HP:0011370)2.97826394
36Hyperammonemia (HP:0001987)2.97720427
37Recurrent abscess formation (HP:0002722)2.96212745
38Hypoglycemic coma (HP:0001325)2.92701643
39Hyperlipoproteinemia (HP:0010980)2.91159242
40Glomerulonephritis (HP:0000099)2.90233914
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.89665287
42Hypoalphalipoproteinemia (HP:0003233)2.89294963
43Obstructive lung disease (HP:0006536)2.88869547
44Chronic obstructive pulmonary disease (HP:0006510)2.88869547
45Abnormality of purine metabolism (HP:0004352)2.82986917
46Pulmonary infiltrates (HP:0002113)2.81123216
47Gout (HP:0001997)2.80364408
48Hypolipoproteinemia (HP:0010981)2.78559508
49Keratoconjunctivitis (HP:0001096)2.75553530
50Encephalitis (HP:0002383)2.75285462
51Hyperglycinuria (HP:0003108)2.74319279
52Abnormality of the intrinsic pathway (HP:0010989)2.69650100
53Autoimmune hemolytic anemia (HP:0001890)2.66976253
54Gastrointestinal stroma tumor (HP:0100723)2.66921400
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65128163
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.64921677
57Osteomyelitis (HP:0002754)2.64607587
58Chest pain (HP:0100749)2.63552268
59Colitis (HP:0002583)2.61321883
60Autoimmune thrombocytopenia (HP:0001973)2.61146891
61Increased IgE level (HP:0003212)2.59498447
62Gingival bleeding (HP:0000225)2.59194263
63Urticaria (HP:0001025)2.58818425
64Hemoptysis (HP:0002105)2.57846599
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.57249878
66Mitral stenosis (HP:0001718)2.54322952
67Abnormality of methionine metabolism (HP:0010901)2.52080078
68Abnormality of fatty-acid metabolism (HP:0004359)2.51730840
69Abnormality of the fingertips (HP:0001211)2.51558307
70Recurrent bronchitis (HP:0002837)2.49744507
71Nephritis (HP:0000123)2.47699604
72Abnormality of nucleobase metabolism (HP:0010932)2.47172351
73Esophageal varix (HP:0002040)2.36390225
74Abnormality of T cells (HP:0002843)2.36167839
75Fat malabsorption (HP:0002630)2.34815496
76Hepatocellular carcinoma (HP:0001402)2.33778078
77Mediastinal lymphadenopathy (HP:0100721)2.33366504
78Pulmonary embolism (HP:0002204)2.32938991
79Recurrent fungal infections (HP:0002841)2.26431048
80Viral hepatitis (HP:0006562)2.25305132
81Slow saccadic eye movements (HP:0000514)2.24958294
82Panhypogammaglobulinemia (HP:0003139)2.23733900
83Abnormal platelet volume (HP:0011876)2.22853806
84Hematochezia (HP:0002573)2.21932257
85Purpura (HP:0000979)2.21702713
86Conjugated hyperbilirubinemia (HP:0002908)2.21337628
87Periodontitis (HP:0000704)2.20500827
88Petechiae (HP:0000967)2.20331534
89Recurrent skin infections (HP:0001581)2.20137754
90Sensorimotor neuropathy (HP:0007141)2.19189738
91Gingivitis (HP:0000230)2.18786343
92Abnormality of proline metabolism (HP:0010907)2.18223475
93Hydroxyprolinuria (HP:0003080)2.18223475
94Hypercholesterolemia (HP:0003124)2.17319924
95Leukocytosis (HP:0001974)2.17093746
96Skin nodule (HP:0200036)2.16371648
97Arterial thrombosis (HP:0004420)2.16292023
98Chronic diarrhea (HP:0002028)2.16089216
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.14846076
100Pustule (HP:0200039)2.13214315
101Abnormality of glycine metabolism (HP:0010895)2.12831739
102Abnormality of serine family amino acid metabolism (HP:0010894)2.12831739
103Recurrent viral infections (HP:0004429)2.11607302
104Lymphopenia (HP:0001888)2.11297591
105Decreased circulating renin level (HP:0003351)2.10066333
106Vertigo (HP:0002321)2.08442305
107Increased IgM level (HP:0003496)2.07394495
108Granulocytopenia (HP:0001913)2.07000979
109Abnormality of liposaccharide metabolism (HP:0010968)2.06465523
110Abnormality of glycosphingolipid metabolism (HP:0004343)2.06465523
111Abnormality of glycolipid metabolism (HP:0010969)2.06465523
112Hyperglycemia (HP:0003074)2.06205144
113Hyperglycinemia (HP:0002154)2.06033555
114Hyperuricemia (HP:0002149)2.05238790
115Increased purine levels (HP:0004368)2.05238790
116Abnormality of cells of the lymphoid lineage (HP:0012140)2.04919037
117Menorrhagia (HP:0000132)2.04126962
118Agammaglobulinemia (HP:0004432)2.03277689
119Generalized aminoaciduria (HP:0002909)2.02125147
120Late onset (HP:0003584)2.00453654
121Restrictive lung disease (HP:0002091)1.99663633
122Inflammation of the large intestine (HP:0002037)1.98685477
123Joint swelling (HP:0001386)1.98324083
124Thrombophlebitis (HP:0004418)1.97813167
125Glomerulopathy (HP:0100820)1.96729386
126Abnormality of T cell physiology (HP:0011840)1.95727504
127Asymmetric septal hypertrophy (HP:0001670)1.95319280
128Gangrene (HP:0100758)1.94672920
129Interstitial pulmonary disease (HP:0006530)1.93448271
130IgM deficiency (HP:0002850)1.93372678
131Eosinophilia (HP:0001880)1.91213130
132Cellulitis (HP:0100658)1.90976685
133IgA deficiency (HP:0002720)1.90923765
134Fatigue (HP:0012378)1.90311603
135Metabolic acidosis (HP:0001942)1.90159516
136Right ventricular cardiomyopathy (HP:0011663)1.90064627
137Sepsis (HP:0100806)1.89328005
138Abnormality of the pleura (HP:0002103)1.89085732
139Hypergammaglobulinemia (HP:0010702)1.88753532
140Dysostosis multiplex (HP:0000943)1.88475158
141Vasculitis (HP:0002633)1.87823261
142Increased mean platelet volume (HP:0011877)1.87350086
143Abnormal platelet function (HP:0011869)1.86685240
144Impaired platelet aggregation (HP:0003540)1.86685240
145Epistaxis (HP:0000421)1.84700693
146Recurrent sinusitis (HP:0011108)1.84683729
147Subacute progressive viral hepatitis (HP:0006572)1.84634342
148Amyloidosis (HP:0011034)1.84545248
149Gastrointestinal inflammation (HP:0004386)1.84149136
150Emphysema (HP:0002097)1.84106790
151Abnormality of polysaccharide metabolism (HP:0011012)1.83145588
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83145588
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83145588
154Acute hepatic failure (HP:0006554)1.82687612
155Abnormality of macrophages (HP:0004311)1.82525143
156Polycythemia (HP:0001901)1.82461411
157Arthralgia (HP:0002829)1.81796895
158Vascular calcification (HP:0004934)1.81450274
159Tetraparesis (HP:0002273)1.80486241
160Hypoglycemic seizures (HP:0002173)1.79933402
161Abnormality of the peritoneum (HP:0002585)1.79224057
162Urinary glycosaminoglycan excretion (HP:0003541)1.79152456
163Mucopolysacchariduria (HP:0008155)1.79152456
164Ventricular fibrillation (HP:0001663)1.78305458
165Increased cerebral lipofuscin (HP:0011813)1.77704898
166Abnormality of pyrimidine metabolism (HP:0004353)1.75543220
167Verrucae (HP:0200043)1.74644323
168Papilloma (HP:0012740)1.74644323
169Meningitis (HP:0001287)1.74321930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.44104871
2RIPK43.37470384
3MAP4K13.05386931
4MAP3K142.68956641
5TYK22.53586127
6ERN12.53256263
7IRAK32.47747196
8TAOK32.41667351
9JAK32.11056960
10FGFR42.07568494
11MAP3K132.05141336
12* JAK12.04049805
13TRIB31.92310214
14FRK1.91293981
15TBK11.82935511
16SIK11.80021495
17FGFR31.79853134
18INSRR1.78613136
19RIPK11.66083960
20IKBKE1.65782881
21CAMK1D1.60910901
22SGK31.52388110
23DAPK21.50816922
24BCKDK1.43431943
25MAP3K101.41662723
26SGK21.37755386
27GRK61.30101548
28PIK3CG1.29566537
29TGFBR21.28983578
30CSK1.26897526
31IRAK41.26846435
32FGR1.26560583
33* JAK21.26369437
34NEK91.21606905
35AKT31.19760077
36CAMK1G1.18139308
37TXK1.17955314
38SIK21.17918064
39PKN21.17667528
40PTK61.16395752
41MAP2K31.10123261
42TTN1.09961298
43IKBKB1.09565828
44ZAP701.06704896
45MST1R1.06095449
46MARK31.05894139
47MAP3K71.05456929
48CHUK1.04911096
49CSF1R1.04260298
50SYK1.03286834
51MAP3K31.02530252
52TAOK21.02408689
53STK101.01740327
54BTK0.98039673
55PRKAA20.96522583
56ITK0.94673880
57KIT0.93888386
58IRAK10.92209001
59BLK0.89780355
60PRKCH0.89528559
61MARK20.85601540
62CAMKK20.84019293
63LATS10.83235837
64TAOK10.83192629
65* PDK10.82531888
66MAP3K60.82372722
67HCK0.81706584
68CDK120.77521827
69STK240.77247369
70MATK0.76876702
71MAP3K10.76863839
72FES0.76633441
73TEC0.75142403
74MAPK110.74607717
75WNK10.71645141
76EPHB10.71462613
77* PDPK10.71060827
78SIK30.69349095
79PDK30.69206643
80PDK40.69206643
81IRAK20.67953975
82YES10.65731231
83CAMKK10.65425764
84PRKAA10.64729936
85LMTK20.63850175
86BMPR20.60953349
87PTK2B0.59972540
88GRK50.59435180
89MAP3K110.58941875
90ERBB40.58204098
91PRKCQ0.57786281
92LCK0.57424698
93EPHA30.57169290
94MAPK120.57167163
95CAMK40.56743630
96KSR20.56234419
97GRK70.55164179
98LRRK20.55062877
99PDK20.54701840
100FYN0.54644896
101SGK2230.53546355
102SGK4940.53546355
103LYN0.52929913
104MAP3K20.51500101
105MAP2K40.51491124
106STK380.48603558
107CDK60.47025519
108NLK0.45875369
109RAF10.45393025
110EGFR0.44976141
111CDC42BPA0.44167762
112DDR20.43816151
113MAPK70.43028694
114HIPK20.42866128
115ABL10.42770133
116PDGFRB0.42178915
117TRPM70.41453391
118MAP2K60.40166308
119RET0.39140557
120MAPK40.38860235
121TNK20.37562364
122* SGK10.36373951
123MYLK0.36358187
124NEK60.35809405

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.63800154
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.32661042
3Nitrogen metabolism_Homo sapiens_hsa009102.83030635
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63503096
5Arginine biosynthesis_Homo sapiens_hsa002202.57445727
6Staphylococcus aureus infection_Homo sapiens_hsa051502.55687255
7Fatty acid degradation_Homo sapiens_hsa000712.47628722
8Allograft rejection_Homo sapiens_hsa053302.27663103
9Complement and coagulation cascades_Homo sapiens_hsa046102.20662683
10Graft-versus-host disease_Homo sapiens_hsa053322.17032244
11Tryptophan metabolism_Homo sapiens_hsa003802.16828389
12Autoimmune thyroid disease_Homo sapiens_hsa053202.10772109
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02390753
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88594953
15PPAR signaling pathway_Homo sapiens_hsa033201.85330349
16Propanoate metabolism_Homo sapiens_hsa006401.85264497
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68726840
18Caffeine metabolism_Homo sapiens_hsa002321.68419505
19Type I diabetes mellitus_Homo sapiens_hsa049401.61894596
20Asthma_Homo sapiens_hsa053101.54980789
21Fatty acid metabolism_Homo sapiens_hsa012121.50111531
22Platelet activation_Homo sapiens_hsa046111.49204341
23Peroxisome_Homo sapiens_hsa041461.49002565
24Malaria_Homo sapiens_hsa051441.41614903
25beta-Alanine metabolism_Homo sapiens_hsa004101.40672041
26Viral myocarditis_Homo sapiens_hsa054161.37711358
27B cell receptor signaling pathway_Homo sapiens_hsa046621.35770314
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34647599
29Starch and sucrose metabolism_Homo sapiens_hsa005001.33563327
30ABC transporters_Homo sapiens_hsa020101.31705428
31Lysine degradation_Homo sapiens_hsa003101.27828898
32Insulin resistance_Homo sapiens_hsa049311.26623111
33Butanoate metabolism_Homo sapiens_hsa006501.25405844
34Osteoclast differentiation_Homo sapiens_hsa043801.23806301
35Non-small cell lung cancer_Homo sapiens_hsa052231.23586400
36Antigen processing and presentation_Homo sapiens_hsa046121.20087776
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17922928
38Bile secretion_Homo sapiens_hsa049761.17363517
39Leishmaniasis_Homo sapiens_hsa051401.16298623
40Hepatitis B_Homo sapiens_hsa051611.15574919
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.12431825
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11015151
43Phenylalanine metabolism_Homo sapiens_hsa003601.09227996
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08947021
45Herpes simplex infection_Homo sapiens_hsa051681.08407764
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.08389733
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06299615
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04959392
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.03380783
50Rheumatoid arthritis_Homo sapiens_hsa053231.02826442
51Selenocompound metabolism_Homo sapiens_hsa004501.02640617
52Type II diabetes mellitus_Homo sapiens_hsa049301.00382867
53African trypanosomiasis_Homo sapiens_hsa051430.99353073
54Phagosome_Homo sapiens_hsa041450.98968024
55Chronic myeloid leukemia_Homo sapiens_hsa052200.98571077
56Chemical carcinogenesis_Homo sapiens_hsa052040.97375326
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95073791
58Histidine metabolism_Homo sapiens_hsa003400.94352836
59VEGF signaling pathway_Homo sapiens_hsa043700.94217956
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.93061659
61Sulfur metabolism_Homo sapiens_hsa009200.92334140
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91303888
63Renal cell carcinoma_Homo sapiens_hsa052110.87834406
64Pyruvate metabolism_Homo sapiens_hsa006200.87822044
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86567842
66Long-term potentiation_Homo sapiens_hsa047200.85279498
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85114848
68* Apoptosis_Homo sapiens_hsa042100.85030792
69* Neurotrophin signaling pathway_Homo sapiens_hsa047220.84310123
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.84190052
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84144612
72GnRH signaling pathway_Homo sapiens_hsa049120.84105614
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82645601
74Glycerolipid metabolism_Homo sapiens_hsa005610.81577990
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79773770
76Ovarian steroidogenesis_Homo sapiens_hsa049130.77219293
77Carbon metabolism_Homo sapiens_hsa012000.76915334
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.75907278
79Tuberculosis_Homo sapiens_hsa051520.74718137
80* Sphingolipid signaling pathway_Homo sapiens_hsa040710.74309478
81Inositol phosphate metabolism_Homo sapiens_hsa005620.72371599
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.72319286
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71677020
84Primary immunodeficiency_Homo sapiens_hsa053400.70932125
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70171312
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69692002
87Choline metabolism in cancer_Homo sapiens_hsa052310.69458700
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.68287563
89Retinol metabolism_Homo sapiens_hsa008300.67433473
90Glioma_Homo sapiens_hsa052140.66681079
91Toxoplasmosis_Homo sapiens_hsa051450.66523305
92Salmonella infection_Homo sapiens_hsa051320.66004537
93Tyrosine metabolism_Homo sapiens_hsa003500.65672047
94Shigellosis_Homo sapiens_hsa051310.65640572
95Systemic lupus erythematosus_Homo sapiens_hsa053220.65382126
96Measles_Homo sapiens_hsa051620.65377481
97Influenza A_Homo sapiens_hsa051640.64403733
98* TNF signaling pathway_Homo sapiens_hsa046680.64283297
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64262141
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63557898
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62887992
102Pertussis_Homo sapiens_hsa051330.62880864
103Vitamin digestion and absorption_Homo sapiens_hsa049770.62709149
104Endometrial cancer_Homo sapiens_hsa052130.62354804
105Viral carcinogenesis_Homo sapiens_hsa052030.62105033
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61890943
107Endocytosis_Homo sapiens_hsa041440.61430071
108HIF-1 signaling pathway_Homo sapiens_hsa040660.58910408
109Glucagon signaling pathway_Homo sapiens_hsa049220.58071258
110Legionellosis_Homo sapiens_hsa051340.56753468
111Estrogen signaling pathway_Homo sapiens_hsa049150.56327315
112Prolactin signaling pathway_Homo sapiens_hsa049170.54557195
113Acute myeloid leukemia_Homo sapiens_hsa052210.54225412
114ErbB signaling pathway_Homo sapiens_hsa040120.54205954
115* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53422959
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52916926
117Fatty acid biosynthesis_Homo sapiens_hsa000610.52753643
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52493268
119Hematopoietic cell lineage_Homo sapiens_hsa046400.52010438
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51657434
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.51643187
122Pancreatic secretion_Homo sapiens_hsa049720.51502468
123Fat digestion and absorption_Homo sapiens_hsa049750.51195777
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50647076
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.49852204
126T cell receptor signaling pathway_Homo sapiens_hsa046600.49643419
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49067170
128Chemokine signaling pathway_Homo sapiens_hsa040620.49056496
129* MAPK signaling pathway_Homo sapiens_hsa040100.46446494
130HTLV-I infection_Homo sapiens_hsa051660.46402619
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46399839
132Dorso-ventral axis formation_Homo sapiens_hsa043200.46182836
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.45686560
134Prostate cancer_Homo sapiens_hsa052150.45684248
135Insulin signaling pathway_Homo sapiens_hsa049100.45626016
136Epstein-Barr virus infection_Homo sapiens_hsa051690.45353444
137Hepatitis C_Homo sapiens_hsa051600.42261259
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41196820
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39923902
140Pancreatic cancer_Homo sapiens_hsa052120.39761487
141mTOR signaling pathway_Homo sapiens_hsa041500.37556276
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37412759
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35377965
144FoxO signaling pathway_Homo sapiens_hsa040680.35166267
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35051825
146Biosynthesis of amino acids_Homo sapiens_hsa012300.34866372
147Lysosome_Homo sapiens_hsa041420.33329459
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32824980
149Other glycan degradation_Homo sapiens_hsa005110.32779892
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32407594
151Prion diseases_Homo sapiens_hsa050200.32168253
152Amoebiasis_Homo sapiens_hsa051460.31886553

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