MAP3K6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.57747465
2regulation of integrin activation (GO:0033623)6.61874942
3embryonic process involved in female pregnancy (GO:0060136)6.01511879
4desmosome organization (GO:0002934)5.97383023
5transcription from mitochondrial promoter (GO:0006390)5.78990822
6replication fork processing (GO:0031297)5.43305575
7proline metabolic process (GO:0006560)5.43010164
8establishment of apical/basal cell polarity (GO:0035089)5.06628019
9positive regulation of protein homooligomerization (GO:0032464)4.97267398
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.43716447
11embryonic placenta development (GO:0001892)4.32433603
12negative regulation of Ras GTPase activity (GO:0034261)4.31584677
13oxidative demethylation (GO:0070989)4.31564063
14establishment or maintenance of monopolar cell polarity (GO:0061339)4.20347294
15establishment of monopolar cell polarity (GO:0061162)4.20347294
16regulation of protein homooligomerization (GO:0032462)4.18118608
17negative regulation of stress fiber assembly (GO:0051497)4.03812967
18regulation of sister chromatid cohesion (GO:0007063)4.01954802
19mitochondrial DNA metabolic process (GO:0032042)3.98942219
20barbed-end actin filament capping (GO:0051016)3.91054713
21DNA deamination (GO:0045006)3.87593926
22skin morphogenesis (GO:0043589)3.82848764
23regulation of water loss via skin (GO:0033561)3.78066791
24protein localization to endosome (GO:0036010)3.77749747
25poly(A)+ mRNA export from nucleus (GO:0016973)3.70720583
26epithelial cell-cell adhesion (GO:0090136)3.69179905
27establishment of skin barrier (GO:0061436)3.68150405
28apoptotic process involved in morphogenesis (GO:0060561)3.67566284
29negative regulation of fatty acid biosynthetic process (GO:0045717)3.66555750
30mitotic G1 DNA damage checkpoint (GO:0031571)3.66494580
31endothelial cell chemotaxis (GO:0035767)3.66164557
32vascular endothelial growth factor signaling pathway (GO:0038084)3.64054481
33atrioventricular valve morphogenesis (GO:0003181)3.62696047
34hemidesmosome assembly (GO:0031581)3.61357606
35semaphorin-plexin signaling pathway (GO:0071526)3.61336690
36glial cell migration (GO:0008347)3.59420925
37negative regulation of cell cycle arrest (GO:0071157)3.58467358
38molting cycle (GO:0042303)3.58319500
39hair cycle (GO:0042633)3.58319500
40basement membrane organization (GO:0071711)3.57253903
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52024716
42regulation of cAMP-dependent protein kinase activity (GO:2000479)3.50266451
43embryonic camera-type eye development (GO:0031076)3.50147088
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49336795
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49336795
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.49336795
47adherens junction assembly (GO:0034333)3.49218912
48cell migration involved in heart development (GO:0060973)3.47464633
49base-excision repair, AP site formation (GO:0006285)3.45116694
50anatomical structure regression (GO:0060033)3.43834803
51regulation of translational fidelity (GO:0006450)3.40102085
52bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39720460
53cellular response to zinc ion (GO:0071294)3.36830465
54focal adhesion assembly (GO:0048041)3.36700428
55cell-substrate adherens junction assembly (GO:0007045)3.36700428
56protein heterotrimerization (GO:0070208)3.36694553
57cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.32238261
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.28541040
59positive regulation of protein oligomerization (GO:0032461)3.28466553
60regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.24464652
61endodermal cell differentiation (GO:0035987)3.24014824
62negative regulation of JAK-STAT cascade (GO:0046426)3.21839868
63mitotic G1/S transition checkpoint (GO:0044819)3.20434941
64surfactant homeostasis (GO:0043129)3.19931219
65virion attachment to host cell (GO:0019062)3.18216277
66adhesion of symbiont to host cell (GO:0044650)3.18216277
67cytoskeletal anchoring at plasma membrane (GO:0007016)3.18015832
68regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16946245
69regulation of hippo signaling (GO:0035330)3.16783473
70DNA strand renaturation (GO:0000733)3.15527663
71meiotic chromosome segregation (GO:0045132)3.14675001
72vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.14309965
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.12579331
74regulation of macrophage chemotaxis (GO:0010758)3.11555205
75G1 DNA damage checkpoint (GO:0044783)3.10410637
76Golgi transport vesicle coating (GO:0048200)3.10324908
77COPI coating of Golgi vesicle (GO:0048205)3.10324908
78extracellular matrix assembly (GO:0085029)3.10070364
79labyrinthine layer development (GO:0060711)3.06352452
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.04365361
81regulation of integrin-mediated signaling pathway (GO:2001044)3.04284093
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02718931
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.02718931
84dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.02682498
85cellular response to ATP (GO:0071318)3.00917300
86mannose metabolic process (GO:0006013)3.00894700
87adhesion of symbiont to host (GO:0044406)3.00640954
88face development (GO:0060324)2.98794437
89hypotonic response (GO:0006971)2.97981212
90keratinization (GO:0031424)2.95723508
91regulation of early endosome to late endosome transport (GO:2000641)2.93900890
92peptide cross-linking (GO:0018149)2.93687059
93trophectodermal cell differentiation (GO:0001829)2.92913868
94positive regulation of blood vessel endothelial cell migration (GO:0043536)2.92392807
95nodal signaling pathway (GO:0038092)2.91693323
96extracellular fibril organization (GO:0043206)2.91367367
97endothelial cell morphogenesis (GO:0001886)2.89824589
98positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.89763515
99negative regulation of fatty acid transport (GO:2000192)2.87823641
100low-density lipoprotein particle clearance (GO:0034383)2.86904858
101collagen fibril organization (GO:0030199)2.84304785
102maturation of 5.8S rRNA (GO:0000460)2.83622948
103collagen metabolic process (GO:0032963)2.83093210
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81660467
105fibril organization (GO:0097435)2.81631187
106base-excision repair (GO:0006284)2.80772220
107regulation of protein oligomerization (GO:0032459)2.80671051
108negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.80572301
109negative regulation of actin filament bundle assembly (GO:0032232)2.78119541
110negative regulation of erythrocyte differentiation (GO:0045647)2.77451821
111regulation of glomerular filtration (GO:0003093)2.75448025
112regulation of mononuclear cell migration (GO:0071675)2.75016815
113extracellular matrix disassembly (GO:0022617)2.74710713
114apoptotic cell clearance (GO:0043277)2.74680558
115convergent extension (GO:0060026)2.74439516
116regulation of female gonad development (GO:2000194)2.74436719
117multicellular organismal water homeostasis (GO:0050891)2.74211549
118negative regulation of viral release from host cell (GO:1902187)2.73715008
119negative regulation of tumor necrosis factor production (GO:0032720)2.73546017
120positive regulation of receptor recycling (GO:0001921)2.73030899
121glandular epithelial cell development (GO:0002068)2.72087876
122negative regulation of chondrocyte differentiation (GO:0032331)2.71684519
123carnitine shuttle (GO:0006853)2.70819790
124collagen catabolic process (GO:0030574)2.70423167
125negative regulation of cartilage development (GO:0061037)2.69686683
126positive regulation of developmental pigmentation (GO:0048087)2.69403484
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68769587
128pyrimidine nucleotide catabolic process (GO:0006244)2.67803384
129positive regulation of chromosome segregation (GO:0051984)2.67178627
130regulation of protein polyubiquitination (GO:1902914)2.65569250
131dosage compensation (GO:0007549)2.65437297
132keratinocyte proliferation (GO:0043616)2.63797868
133negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.62916887
134glomerular basement membrane development (GO:0032836)2.62878720
135fatty acid transmembrane transport (GO:1902001)2.62771527
136multicellular organismal macromolecule metabolic process (GO:0044259)2.61386334
137negative regulation of glial cell proliferation (GO:0060253)2.61324772
138negative regulation of protein oligomerization (GO:0032460)2.60735329
139glutamine family amino acid biosynthetic process (GO:0009084)2.59938368
140protein retention in ER lumen (GO:0006621)2.59778812
141embryonic eye morphogenesis (GO:0048048)2.58194678
142renal filtration (GO:0097205)2.58037390
143stress fiber assembly (GO:0043149)2.57774994
144cell volume homeostasis (GO:0006884)2.56504307
145negative regulation of adherens junction organization (GO:1903392)2.55543973
146negative regulation of focal adhesion assembly (GO:0051895)2.55543973
147negative regulation of cell junction assembly (GO:1901889)2.55543973
148apoptotic process involved in development (GO:1902742)2.54934010
149positive regulation of p38MAPK cascade (GO:1900745)2.54493493
150negative regulation of cell size (GO:0045792)2.53958418
151pinocytosis (GO:0006907)2.52605317
152regulation of podosome assembly (GO:0071801)2.50598708
153insulin-like growth factor receptor signaling pathway (GO:0048009)2.50082043
154mitotic cell cycle arrest (GO:0071850)2.49850400
155regulation of tight junction assembly (GO:2000810)2.48300617
156multicellular organismal metabolic process (GO:0044236)2.46582816
157positive regulation of T cell apoptotic process (GO:0070234)2.46254201
158maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.45889258
159multicellular organismal catabolic process (GO:0044243)2.45773038
160positive regulation of Cdc42 GTPase activity (GO:0043089)2.45765298
161regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.45686054
162cell-substrate junction assembly (GO:0007044)2.45571800
163cell-cell junction maintenance (GO:0045217)2.45534174
164DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.45357048
165regulation of membrane protein ectodomain proteolysis (GO:0051043)2.44162584
166negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.44057271
167regulation of extracellular matrix disassembly (GO:0010715)2.43992636
168regulation of p38MAPK cascade (GO:1900744)2.42215055
169response to laminar fluid shear stress (GO:0034616)2.41085239
170venous blood vessel morphogenesis (GO:0048845)2.40853932
171retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39865274
172endocytic recycling (GO:0032456)2.38388136
173Rho protein signal transduction (GO:0007266)2.37665749
174regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.36862135
175negative regulation of smooth muscle cell migration (GO:0014912)2.35680022
176positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.34915270
177retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34187227
178Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.31682903
179cell adhesion mediated by integrin (GO:0033627)2.31040694
180keratan sulfate catabolic process (GO:0042340)2.29640923
181keratinocyte differentiation (GO:0030216)2.28583427
182chemical homeostasis within a tissue (GO:0048875)2.28397589
183activation of Rac GTPase activity (GO:0032863)2.28313006
184regulation of glucose import in response to insulin stimulus (GO:2001273)2.28158542
185extracellular matrix organization (GO:0030198)2.27282591
186extracellular structure organization (GO:0043062)2.26290286
187response to fluid shear stress (GO:0034405)2.24059928
188peptidyl-proline hydroxylation (GO:0019511)2.23761004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.22225696
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01377287
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85179780
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84032599
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.68792137
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.67755526
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.46341141
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44257769
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.36807999
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33617699
11VDR_21846776_ChIP-Seq_THP-1_Human2.25532365
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20347445
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11969717
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11969717
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11969717
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.10807625
17ZNF263_19887448_ChIP-Seq_K562_Human2.09792114
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.94207375
19* RACK7_27058665_Chip-Seq_MCF-7_Human1.92475049
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91896094
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.88612150
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.85143927
23LXR_22292898_ChIP-Seq_THP-1_Human1.84342322
24* ELK3_25401928_ChIP-Seq_HUVEC_Human1.81785457
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77291265
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.75256165
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74437044
28* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72856470
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71104241
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66168775
31* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65535077
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.61229874
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59724270
34ATF3_27146783_Chip-Seq_COLON_Human1.58596942
35* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58057883
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56321404
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55700634
38POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54429624
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54331681
40* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.52571207
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52181857
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51772619
43* KDM2B_26808549_Chip-Seq_DND41_Human1.49983221
44TCF3_18692474_ChIP-Seq_MESCs_Mouse1.48169274
45* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48093033
46* TBX20_22080862_ChIP-Seq_HEART_Mouse1.47040260
47* TBX20_22328084_ChIP-Seq_HEART_Mouse1.47040260
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.46883675
49MYC_22102868_ChIP-Seq_BL_Human1.46701473
50NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.43048821
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42056071
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41480233
53SMC4_20622854_ChIP-Seq_HELA_Human1.40510746
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40419859
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40024942
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39197332
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38592775
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38166172
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32950471
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32601496
61* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32570910
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.32487280
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31676463
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29922242
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29922242
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.29820967
67UBF1/2_26484160_Chip-Seq_HMECs_Human1.29781557
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28617965
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28261004
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26879948
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25781324
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25327334
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23580664
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23245022
75* CTCF_27219007_Chip-Seq_Bcells_Human1.23159751
76* NANOG_21062744_ChIP-ChIP_HESCs_Human1.22666057
77* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21485936
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20955691
79* CREB1_26743006_Chip-Seq_LNCaP_Human1.20859221
80* KDM2B_26808549_Chip-Seq_K562_Human1.20405979
81* TCF7_22412390_ChIP-Seq_EML_Mouse1.19912715
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17397019
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17295021
84* CLOCK_20551151_ChIP-Seq_293T_Human1.16722399
85* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15515421
86SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15273397
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.15233513
88PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.15189035
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15031868
90CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13388931
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12780646
92* TET1_21490601_ChIP-Seq_MESCs_Mouse1.12574303
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12147358
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11545009
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.10506471
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09951478
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09946529
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09404293
99NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09170997
100PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07606737
101RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07498621
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06652515
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06398058
104* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04770306
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04571323
106* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04193425
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.03763626
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03363020
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02637437
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02556797
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02513794
112TP53_22127205_ChIP-Seq_IMR90_Human1.01311375
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00399484
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99603563
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99280617
116P68_20966046_ChIP-Seq_HELA_Human0.97038582
117* TP63_22573176_ChIP-Seq_HFKS_Human0.96005054
118STAT1_20625510_ChIP-Seq_HELA_Human0.94717626
119* BCOR_27268052_Chip-Seq_Bcells_Human0.94704120
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94520019
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94251121
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93660213
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.92758163
124* TP53_23651856_ChIP-Seq_MEFs_Mouse0.92639875
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92604429
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92177029
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89985397
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89795759
129SPI1_26923725_Chip-Seq_HPCs_Mouse0.89618692
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89182551
131* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89061825
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88955882
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88832966
134POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88415196
135VDR_24763502_ChIP-Seq_THP-1_Human0.88153007
136KLF5_25053715_ChIP-Seq_YYC3_Human0.87900494
137EGR1_19374776_ChIP-ChIP_THP-1_Human0.87130897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.40511416
2MP0000579_abnormal_nail_morphology3.09555458
3MP0003705_abnormal_hypodermis_morpholog2.93673583
4MP0005503_abnormal_tendon_morphology2.90539702
5MP0005275_abnormal_skin_tensile2.84588813
6MP0010030_abnormal_orbit_morphology2.73334467
7MP0002796_impaired_skin_barrier2.60780358
8MP0004185_abnormal_adipocyte_glucose2.49440491
9MP0005171_absent_coat_pigmentation2.47791075
10MP0008057_abnormal_DNA_replication2.47685821
11MP0008438_abnormal_cutaneous_collagen2.44531902
12MP0005257_abnormal_intraocular_pressure2.27402866
13MP0003566_abnormal_cell_adhesion2.25170730
14MP0005670_abnormal_white_adipose2.24676487
15MP0005397_hematopoietic_system_phenotyp2.18201442
16MP0001545_abnormal_hematopoietic_system2.18201442
17MP0002060_abnormal_skin_morphology2.14510905
18MP0005409_darkened_coat_color2.14275898
19MP0004233_abnormal_muscle_weight2.14038943
20MP0005076_abnormal_cell_differentiation2.09621013
21MP0005058_abnormal_lysosome_morphology2.07516787
22MP0005666_abnormal_adipose_tissue1.98555985
23MP0010352_gastrointestinal_tract_polyps1.89683728
24MP0002009_preneoplasia1.87534540
25MP0003045_fibrosis1.86855072
26MP0003828_pulmonary_edema1.86202401
27MP0003646_muscle_fatigue1.75585911
28* MP0003453_abnormal_keratinocyte_physiol1.74133703
29MP0004858_abnormal_nervous_system1.64955293
30MP0006138_congestive_heart_failure1.64703369
31MP0005501_abnormal_skin_physiology1.62987458
32MP0000767_abnormal_smooth_muscle1.61942732
33MP0002249_abnormal_larynx_morphology1.56474912
34MP0004084_abnormal_cardiac_muscle1.54241605
35MP0008995_early_reproductive_senescence1.54141531
36MP0000751_myopathy1.52446609
37MP0003718_maternal_effect1.51260502
38MP0005023_abnormal_wound_healing1.48031231
39MP0009115_abnormal_fat_cell1.45550415
40MP0000013_abnormal_adipose_tissue1.44500993
41MP0002653_abnormal_ependyma_morphology1.44428519
42MP0009384_cardiac_valve_regurgitation1.43331036
43MP0002282_abnormal_trachea_morphology1.41466066
44MP0009840_abnormal_foam_cell1.41014727
45MP0004510_myositis1.38735482
46MP0004130_abnormal_muscle_cell1.36988566
47MP0005375_adipose_tissue_phenotype1.36587443
48MP0002269_muscular_atrophy1.34622187
49MP0005451_abnormal_body_composition1.33939263
50MP0004381_abnormal_hair_follicle1.29515672
51MP0003567_abnormal_fetal_cardiomyocyte1.28620871
52MP0004947_skin_inflammation1.27971210
53MP0002877_abnormal_melanocyte_morpholog1.27716927
54MP0002971_abnormal_brown_adipose1.27040028
55MP0002086_abnormal_extraembryonic_tissu1.25886214
56MP0005330_cardiomyopathy1.21806182
57MP0008260_abnormal_autophagy1.19622756
58MP0009780_abnormal_chondrocyte_physiolo1.17953239
59MP0001243_abnormal_dermal_layer1.16715946
60MP0010094_abnormal_chromosome_stability1.16279598
61MP0008775_abnormal_heart_ventricle1.15021167
62MP0010630_abnormal_cardiac_muscle1.14536854
63MP0001542_abnormal_bone_strength1.13712472
64MP0002295_abnormal_pulmonary_circulatio1.11893118
65MP0004272_abnormal_basement_membrane1.11252569
66MP0004036_abnormal_muscle_relaxation1.10611355
67MP0005508_abnormal_skeleton_morphology1.08763190
68MP0000678_abnormal_parathyroid_gland1.08303447
69MP0004087_abnormal_muscle_fiber1.08142818
70MP0000343_altered_response_to1.07893956
71MP0003111_abnormal_nucleus_morphology1.07372124
72MP0002896_abnormal_bone_mineralization1.07234892
73MP0000749_muscle_degeneration1.06983068
74MP0002970_abnormal_white_adipose1.06906147
75MP0005395_other_phenotype1.06339569
76MP0002084_abnormal_developmental_patter1.04651475
77MP0005623_abnormal_meninges_morphology1.04193395
78MP0000467_abnormal_esophagus_morphology1.03846003
79MP0001348_abnormal_lacrimal_gland1.03724120
80MP0000490_abnormal_crypts_of1.03447120
81MP0000750_abnormal_muscle_regeneration1.03409726
82MP0010234_abnormal_vibrissa_follicle1.03310458
83MP0001697_abnormal_embryo_size1.02971989
84MP0002006_tumorigenesis1.02931848
85MP0004957_abnormal_blastocyst_morpholog1.01667312
86MP0000759_abnormal_skeletal_muscle1.01572854
87MP0005595_abnormal_vascular_smooth1.00524605
88MP0000762_abnormal_tongue_morphology0.99554336
89MP0003941_abnormal_skin_development0.97428436
90MP0002085_abnormal_embryonic_tissue0.96908086
91MP0000858_altered_metastatic_potential0.96612499
92MP0003786_premature_aging0.96342840
93MP0002933_joint_inflammation0.95227929
94MP0001672_abnormal_embryogenesis/_devel0.95008749
95MP0005380_embryogenesis_phenotype0.95008749
96MP0001915_intracranial_hemorrhage0.94491760
97MP0002998_abnormal_bone_remodeling0.93432245
98MP0005165_increased_susceptibility_to0.93372454
99MP0002098_abnormal_vibrissa_morphology0.92774649
100MP0003890_abnormal_embryonic-extraembry0.91099344
101MP0003699_abnormal_female_reproductive0.90979865
102MP0000462_abnormal_digestive_system0.90842398
103MP0000747_muscle_weakness0.90597559
104MP0003172_abnormal_lysosome_physiology0.90077610
105MP0002106_abnormal_muscle_physiology0.89428432
106MP0002332_abnormal_exercise_endurance0.89375596
107MP0002254_reproductive_system_inflammat0.88425603
108MP0003191_abnormal_cellular_cholesterol0.87737133
109MP0002111_abnormal_tail_morphology0.86810601
110MP0004197_abnormal_fetal_growth/weight/0.86755222
111MP0010368_abnormal_lymphatic_system0.86698000
112MP0005390_skeleton_phenotype0.86609276
113MP0004264_abnormal_extraembryonic_tissu0.84959006
114MP0002166_altered_tumor_susceptibility0.84388221
115MP0003279_aneurysm0.84277757
116MP0001216_abnormal_epidermal_layer0.83871294
117MP0010771_integument_phenotype0.82761327
118MP0003300_gastrointestinal_ulcer0.82607304
119MP0000377_abnormal_hair_follicle0.82311069
120MP0002108_abnormal_muscle_morphology0.82175275
121MP0002972_abnormal_cardiac_muscle0.81194749
122MP0009931_abnormal_skin_appearance0.80691957
123MP0002925_abnormal_cardiovascular_devel0.80654506
124MP0008932_abnormal_embryonic_tissue0.80319252
125MP0008877_abnormal_DNA_methylation0.80187994
126MP0000733_abnormal_muscle_development0.79105292
127MP0003984_embryonic_growth_retardation0.79088502
128MP0000566_synostosis0.78989769
129MP0003693_abnormal_embryo_hatching0.78496848
130MP0001299_abnormal_eye_distance/0.78217487
131MP0002168_other_aberrant_phenotype0.78137276
132MP0001849_ear_inflammation0.78114656
133MP0004782_abnormal_surfactant_physiolog0.78100719
134MP0001958_emphysema0.78080691
135MP0003091_abnormal_cell_migration0.77153711
136MP0003283_abnormal_digestive_organ0.76654108
137MP0003950_abnormal_plasma_membrane0.76428056
138MP0003077_abnormal_cell_cycle0.76204122
139MP0000003_abnormal_adipose_tissue0.76161977
140MP0003448_altered_tumor_morphology0.75539507
141MP0002932_abnormal_joint_morphology0.75447106
142MP0002088_abnormal_embryonic_growth/wei0.75223039
143MP0009379_abnormal_foot_pigmentation0.74537201
144MP0001851_eye_inflammation0.70528579
145MP0001533_abnormal_skeleton_physiology0.69758267
146MP0001879_abnormal_lymphatic_vessel0.68292262
147MP0001614_abnormal_blood_vessel0.67745437
148MP0006054_spinal_hemorrhage0.65315410
149MP0003075_altered_response_to0.65067931
150MP0005164_abnormal_response_to0.64590820

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)5.11212717
2Male infertility (HP:0003251)4.70292190
3Hypotrichosis (HP:0001006)4.43453558
4Pustule (HP:0200039)4.14974482
5Cerebral aneurysm (HP:0004944)4.13485679
6Turricephaly (HP:0000262)3.87490789
7Rib fusion (HP:0000902)3.87348394
8Concave nail (HP:0001598)3.79622196
9Ulnar bowing (HP:0003031)3.75663477
10Facial hemangioma (HP:0000329)3.66383933
11Annular pancreas (HP:0001734)3.58603755
12Polycythemia (HP:0001901)3.56192979
13Distal lower limb muscle weakness (HP:0009053)3.52681063
14Cervical subluxation (HP:0003308)3.42162024
15Increased connective tissue (HP:0009025)3.38472997
16Fragile skin (HP:0001030)3.29488016
17Obstructive sleep apnea (HP:0002870)3.10029817
18Coronal craniosynostosis (HP:0004440)3.03393622
19Spinal rigidity (HP:0003306)3.02447019
20Mildly elevated creatine phosphokinase (HP:0008180)3.01450823
21Type 1 muscle fiber predominance (HP:0003803)3.00425780
22Muscle fibrillation (HP:0010546)2.96581924
23Distal lower limb amyotrophy (HP:0008944)2.95543117
24Short humerus (HP:0005792)2.94995166
25Increased variability in muscle fiber diameter (HP:0003557)2.93742858
26Abnormal hemoglobin (HP:0011902)2.87113589
27Poikiloderma (HP:0001029)2.86917993
28Nail dystrophy (HP:0008404)2.85965264
29Rectal fistula (HP:0100590)2.82498279
30Rectovaginal fistula (HP:0000143)2.82498279
31Mesangial abnormality (HP:0001966)2.82459610
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.76210222
33Premature skin wrinkling (HP:0100678)2.72953172
34Aortic dissection (HP:0002647)2.72527355
35Diaphragmatic weakness (HP:0009113)2.70999031
36Tongue fasciculations (HP:0001308)2.70336786
37Aplasia/hypoplasia of the humerus (HP:0006507)2.69463097
38Intestinal fistula (HP:0100819)2.69021667
39Vaginal fistula (HP:0004320)2.68297517
40Bladder diverticulum (HP:0000015)2.67338620
41Vertebral compression fractures (HP:0002953)2.63830510
42Abnormality of nail color (HP:0100643)2.62149995
43Muscle fiber splitting (HP:0003555)2.59916522
44Broad face (HP:0000283)2.59497256
45Abnormality of skeletal muscle fiber size (HP:0012084)2.57109257
46Natal tooth (HP:0000695)2.56750396
47Short chin (HP:0000331)2.56615501
48Congenital hip dislocation (HP:0001374)2.52650629
49Myocardial infarction (HP:0001658)2.48764902
50Joint stiffness (HP:0001387)2.48685300
51Acanthosis nigricans (HP:0000956)2.48243375
52Follicular hyperkeratosis (HP:0007502)2.48210775
53Wormian bones (HP:0002645)2.47509793
54Palmoplantar hyperkeratosis (HP:0000972)2.47464156
55Right ventricular cardiomyopathy (HP:0011663)2.47001879
56Vascular tortuosity (HP:0004948)2.46011463
57Increased IgM level (HP:0003496)2.44220151
58Protrusio acetabuli (HP:0003179)2.43490707
59Growth hormone excess (HP:0000845)2.41513121
60Asymmetric septal hypertrophy (HP:0001670)2.41219958
61Premature rupture of membranes (HP:0001788)2.40796115
62Thin bony cortex (HP:0002753)2.38377970
63Milia (HP:0001056)2.37744812
64Thick nail (HP:0001805)2.36920169
65Plantar hyperkeratosis (HP:0007556)2.36743851
66Distal upper limb amyotrophy (HP:0007149)2.36185317
67Upper limb amyotrophy (HP:0009129)2.36185317
68Ventricular tachycardia (HP:0004756)2.34327212
69Broad metatarsal (HP:0001783)2.33990172
70Dilatation of the ascending aorta (HP:0005111)2.33333706
71Choanal stenosis (HP:0000452)2.31382482
72Nuclear cataract (HP:0100018)2.28669203
73Mitral regurgitation (HP:0001653)2.27881526
74Ankle contracture (HP:0006466)2.27600096
75Selective tooth agenesis (HP:0001592)2.25873771
76Generalized amyotrophy (HP:0003700)2.25872245
77Osteolytic defects of the hand bones (HP:0009699)2.25567775
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.25567775
79Palmar hyperkeratosis (HP:0010765)2.25130074
80Abnormality of the aortic arch (HP:0012303)2.24754646
81Hypoplastic ischia (HP:0003175)2.23179548
82Hypochromic microcytic anemia (HP:0004840)2.22814664
83Difficulty climbing stairs (HP:0003551)2.21872638
84Advanced eruption of teeth (HP:0006288)2.20886466
85Woolly hair (HP:0002224)2.20553495
86Blue sclerae (HP:0000592)2.20501153
87Vertebral hypoplasia (HP:0008417)2.20314000
88Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.20314000
89Neonatal short-limb short stature (HP:0008921)2.20244422
90Bowing of the arm (HP:0006488)2.20038175
91Bowed forearm bones (HP:0003956)2.20038175
92Arterial tortuosity (HP:0005116)2.17405921
93Axonal loss (HP:0003447)2.17195386
94Squamous cell carcinoma (HP:0002860)2.16246778
95Shallow orbits (HP:0000586)2.15219183
96Hyporeflexia of lower limbs (HP:0002600)2.14826429
97Short nail (HP:0001799)2.14242842
98Fatigable weakness (HP:0003473)2.13705999
99Abnormality of the neuromuscular junction (HP:0003398)2.13705999
100Hyperacusis (HP:0010780)2.13704039
101Biconcave vertebral bodies (HP:0004586)2.13531667
102Aortic regurgitation (HP:0001659)2.13226343
103Aneurysm (HP:0002617)2.09784326
104Soft skin (HP:0000977)2.09108267
105Neck muscle weakness (HP:0000467)2.08590928
106Achilles tendon contracture (HP:0001771)2.08153339
107Genu recurvatum (HP:0002816)2.07214273
108Capillary hemangiomas (HP:0005306)2.05715869
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04392510
110Abnormality of polysaccharide metabolism (HP:0011012)2.04392510
111Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04392510
112Bulbar palsy (HP:0001283)2.03951741
113Popliteal pterygium (HP:0009756)2.03570414
114Stridor (HP:0010307)2.02807474
115Mucopolysacchariduria (HP:0008155)2.01860714
116Urinary glycosaminoglycan excretion (HP:0003541)2.01860714
117Split hand (HP:0001171)2.01006329
118Hamartoma (HP:0010566)2.00606668
119Lower limb amyotrophy (HP:0007210)1.99884313
120Round ear (HP:0100830)1.99776874
121Patellar aplasia (HP:0006443)1.99661386
122Shawl scrotum (HP:0000049)1.98825609
123Absent radius (HP:0003974)1.97895044
124Mitral valve prolapse (HP:0001634)1.97729325
125Hypercortisolism (HP:0001578)1.97639548
126Large for gestational age (HP:0001520)1.97420041
127Redundant skin (HP:0001582)1.96229147
128J-shaped sella turcica (HP:0002680)1.94790939
129Aortic aneurysm (HP:0004942)1.93582475
130Broad hallux (HP:0010055)1.92591251
131Premature ovarian failure (HP:0008209)1.90864875
132Joint laxity (HP:0001388)1.90605440
133Interstitial pulmonary disease (HP:0006530)1.89471338
134Disproportionate tall stature (HP:0001519)1.88905183
135Exercise-induced myalgia (HP:0003738)1.88794612
136Abnormality of the distal phalanges of the toes (HP:0010182)1.88226293
137Abnormality of male internal genitalia (HP:0000022)1.87245320
138Atrophic scars (HP:0001075)1.87074232
139Coarse hair (HP:0002208)1.86803887
140Dysostosis multiplex (HP:0000943)1.86075390
141Abnormality of the ischium (HP:0003174)1.85893948
142Increased IgE level (HP:0003212)1.84847832
143Hypoplasia of the iris (HP:0007676)1.84365560
144Albinism (HP:0001022)1.84179329
145Fragile nails (HP:0001808)1.84033840
146Pili torti (HP:0003777)1.83145569
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.82149009
148Slender build (HP:0001533)1.81372779
149Sudden death (HP:0001699)1.80780059
150Lymphangioma (HP:0100764)1.80658118
151Aplasia of the musculature (HP:0100854)1.80600665
152Absent forearm bone (HP:0003953)1.79851916
153Aplasia involving forearm bones (HP:0009822)1.79851916
154Orthostatic hypotension (HP:0001278)1.79682065
155Onycholysis (HP:0001806)1.79395413
156Alacrima (HP:0000522)1.79337500
157Elbow flexion contracture (HP:0002987)1.78957097
158Basal cell carcinoma (HP:0002671)1.78470156
159Aplasia/Hypoplasia of the patella (HP:0006498)1.77973967
160Abnormality of the Achilles tendon (HP:0005109)1.77206059
161Abnormality of dentin (HP:0010299)1.71216826
162Spondylolisthesis (HP:0003302)1.70857293
163Abnormality of the salivary glands (HP:0010286)1.68947471
164Hyperextensible skin (HP:0000974)1.67569892
165Venous abnormality (HP:0002624)1.67113516
166Long toe (HP:0010511)1.63989371
167Coxa vara (HP:0002812)1.63974375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.59211699
2ICK4.58690678
3MAPK153.38663241
4MAP3K113.05418138
5LATS22.71141296
6LATS12.70106169
7PINK12.62614959
8MYLK2.53032312
9TYRO32.49649990
10PDGFRA2.46101534
11BMX2.45213926
12TRIB32.38266707
13FGR2.35722435
14MATK2.30532421
15PRKD22.28363064
16TRPM72.13278670
17PIM22.09350194
18TESK11.97588562
19SMG11.88788642
20CSK1.83915590
21PRPF4B1.75083893
22MAPKAPK31.74450983
23IRAK31.68603191
24PKN21.64013122
25MET1.58140616
26CDK61.51501104
27TAOK11.49045643
28RIPK11.41417790
29DYRK1B1.39453413
30NTRK11.36780389
31DMPK1.33913814
32LMTK21.33841698
33PIM11.31794756
34DAPK11.29191068
35EEF2K1.28402904
36TIE11.28351601
37MAP2K31.27425721
38CDK71.25615822
39TTN1.25144893
40NME21.23546084
41STK31.19738709
42MAPK111.17890890
43RPS6KA21.17090680
44PTK61.14862393
45ERN11.14023865
46MAP3K131.08235401
47GSK3A1.03197646
48RAF11.03088600
49PHKG21.02656419
50PHKG11.02656419
51STK38L1.00681939
52RPS6KB20.99280643
53PRKAA20.98814085
54MAP3K70.98440513
55ERBB40.97964101
56MTOR0.97006601
57EPHA20.96492984
58CAMK1D0.93875080
59PRKAA10.92269199
60STK100.87947902
61CHEK20.87691908
62YES10.87214208
63MOS0.86763585
64RPS6KL10.86048043
65RPS6KC10.86048043
66TBK10.85666544
67CDC42BPA0.85658171
68ZAP700.82847025
69ARAF0.81018128
70AKT30.80414549
71RPS6KA60.79090087
72MAP3K30.78189233
73SIK10.77603198
74MAP3K10.76468791
75MAPK70.75960535
76TGFBR20.72815933
77MUSK0.69638971
78ABL20.69467603
79TTK0.69139655
80MAPK120.68170731
81PDGFRB0.67397451
82PDPK10.66956369
83CDK120.66814820
84HIPK20.66068579
85TAOK30.65900019
86MAP3K20.65651467
87LIMK10.65373470
88MAP2K60.65252762
89TYK20.64843838
90UHMK10.64272608
91ROCK10.62364841
92RPS6KA10.60795488
93PTK20.57782407
94MELK0.57170760
95PLK10.56253862
96NEK90.55442696
97EPHB10.54972020
98ROCK20.53932039
99BLK0.51596337
100PRKG20.51253114
101NEK20.50738607
102PRKD10.49051796
103RET0.48751334
104EPHB20.48341566
105PRKD30.46967273
106MAPK40.46454282
107FER0.45802230
108EPHA30.45498971
109EGFR0.43725631
110TAOK20.43004934
111DAPK30.42955396
112JAK30.42718614
113FGFR40.42461967
114KSR20.42280782
115PAK20.41381583
116MST1R0.41000187
117CDK90.40692678
118MAPKAPK20.40414410
119CDK80.39915037
120LRRK20.39162123
121CAMK2G0.38610884
122JAK20.38463838
123MAPK10.38205145
124MAP3K80.37767091
125PTK2B0.37759872
126PDK20.37176531
127DYRK30.36299805
128MAP3K100.35114627
129MAP3K90.34937408
130PAK40.32663276
131TGFBR10.32626888
132DYRK20.32433975
133KDR0.32345796
134ILK0.31835997
135JAK10.30140881
136MARK20.29948480
137MAP2K10.29803440
138MAPK30.29481552
139FGFR30.29382889
140PAK10.29141065
141ABL10.28540620
142STK380.28457055
143FLT30.26499907

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.36368706
2Base excision repair_Homo sapiens_hsa034102.99687772
3Other glycan degradation_Homo sapiens_hsa005112.68307711
4Circadian rhythm_Homo sapiens_hsa047102.60660126
5Adherens junction_Homo sapiens_hsa045202.49005004
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.43604268
7Mismatch repair_Homo sapiens_hsa034302.32205554
8TGF-beta signaling pathway_Homo sapiens_hsa043502.05767825
9Notch signaling pathway_Homo sapiens_hsa043302.04903789
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.99006901
11Hippo signaling pathway_Homo sapiens_hsa043901.92148621
12mTOR signaling pathway_Homo sapiens_hsa041501.88078718
13Bladder cancer_Homo sapiens_hsa052191.73278337
14p53 signaling pathway_Homo sapiens_hsa041151.73011029
15Longevity regulating pathway - mammal_Homo sapiens_hsa042111.67167363
16Fatty acid metabolism_Homo sapiens_hsa012121.66619357
17DNA replication_Homo sapiens_hsa030301.64805175
18Dorso-ventral axis formation_Homo sapiens_hsa043201.57553035
19Small cell lung cancer_Homo sapiens_hsa052221.53316578
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49814711
21Cell cycle_Homo sapiens_hsa041101.47863907
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45008688
23VEGF signaling pathway_Homo sapiens_hsa043701.44292010
24Prion diseases_Homo sapiens_hsa050201.43364395
25MicroRNAs in cancer_Homo sapiens_hsa052061.43226287
26ECM-receptor interaction_Homo sapiens_hsa045121.42973191
27Lysosome_Homo sapiens_hsa041421.39537112
28Focal adhesion_Homo sapiens_hsa045101.38188397
29Hedgehog signaling pathway_Homo sapiens_hsa043401.38115048
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.31017147
31Lysine degradation_Homo sapiens_hsa003101.28292566
32Pancreatic cancer_Homo sapiens_hsa052121.25410716
33AMPK signaling pathway_Homo sapiens_hsa041521.25230365
34Protein digestion and absorption_Homo sapiens_hsa049741.23356743
35Arginine and proline metabolism_Homo sapiens_hsa003301.18400365
36Chronic myeloid leukemia_Homo sapiens_hsa052201.18367835
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.18187156
38Shigellosis_Homo sapiens_hsa051311.17236955
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17160421
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16214652
41Proteoglycans in cancer_Homo sapiens_hsa052051.15296411
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12064117
43Basal cell carcinoma_Homo sapiens_hsa052171.10852474
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08278465
45Acute myeloid leukemia_Homo sapiens_hsa052211.06450920
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.05795377
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04311975
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03238754
49Malaria_Homo sapiens_hsa051441.03104881
50Galactose metabolism_Homo sapiens_hsa000521.02692059
51Colorectal cancer_Homo sapiens_hsa052101.02360387
52Insulin signaling pathway_Homo sapiens_hsa049100.98095098
53Glioma_Homo sapiens_hsa052140.98001510
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.96632465
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.95572574
56PPAR signaling pathway_Homo sapiens_hsa033200.95418267
57Pertussis_Homo sapiens_hsa051330.93787856
58Phenylalanine metabolism_Homo sapiens_hsa003600.93771235
59mRNA surveillance pathway_Homo sapiens_hsa030150.93366776
60Tight junction_Homo sapiens_hsa045300.93210105
61Renal cell carcinoma_Homo sapiens_hsa052110.91972977
62TNF signaling pathway_Homo sapiens_hsa046680.91824384
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91632385
64Viral myocarditis_Homo sapiens_hsa054160.90944001
65Estrogen signaling pathway_Homo sapiens_hsa049150.90530732
66Nucleotide excision repair_Homo sapiens_hsa034200.89673490
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87382882
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87063130
69Pentose phosphate pathway_Homo sapiens_hsa000300.86898048
70Toxoplasmosis_Homo sapiens_hsa051450.86598807
71Thyroid cancer_Homo sapiens_hsa052160.84887417
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84497878
73RNA transport_Homo sapiens_hsa030130.84095164
74Wnt signaling pathway_Homo sapiens_hsa043100.84095020
75Endocytosis_Homo sapiens_hsa041440.82182879
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81836644
77Melanogenesis_Homo sapiens_hsa049160.81141966
78Choline metabolism in cancer_Homo sapiens_hsa052310.80513950
79Ovarian steroidogenesis_Homo sapiens_hsa049130.80135529
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.79510961
81Axon guidance_Homo sapiens_hsa043600.79489313
82Homologous recombination_Homo sapiens_hsa034400.79347516
83Biosynthesis of amino acids_Homo sapiens_hsa012300.78957486
84Osteoclast differentiation_Homo sapiens_hsa043800.78137975
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78134230
86Salmonella infection_Homo sapiens_hsa051320.77569964
87Oocyte meiosis_Homo sapiens_hsa041140.76375974
88Linoleic acid metabolism_Homo sapiens_hsa005910.76323091
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75587150
90Hepatitis C_Homo sapiens_hsa051600.73956322
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73917868
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73907270
93Caffeine metabolism_Homo sapiens_hsa002320.72246667
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71971369
95Vibrio cholerae infection_Homo sapiens_hsa051100.70552396
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70505069
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69522326
98Platelet activation_Homo sapiens_hsa046110.68432144
99Amoebiasis_Homo sapiens_hsa051460.68341934
100Non-small cell lung cancer_Homo sapiens_hsa052230.68228818
101Endometrial cancer_Homo sapiens_hsa052130.68199976
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67664838
103HIF-1 signaling pathway_Homo sapiens_hsa040660.67462312
104Arginine biosynthesis_Homo sapiens_hsa002200.67418380
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65885797
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65757640
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65258793
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65121716
109Pathways in cancer_Homo sapiens_hsa052000.63925375
110Fanconi anemia pathway_Homo sapiens_hsa034600.63739619
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.62694871
112Insulin resistance_Homo sapiens_hsa049310.62067681
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61499350
114Sulfur relay system_Homo sapiens_hsa041220.61488452
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.60714861
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57587981
117HTLV-I infection_Homo sapiens_hsa051660.57172927
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56581166
119Complement and coagulation cascades_Homo sapiens_hsa046100.56468172
120Prostate cancer_Homo sapiens_hsa052150.56198728
121GnRH signaling pathway_Homo sapiens_hsa049120.55792030
122Hepatitis B_Homo sapiens_hsa051610.55224348
123Glycerolipid metabolism_Homo sapiens_hsa005610.55006853
124Fat digestion and absorption_Homo sapiens_hsa049750.54926122
125Renin secretion_Homo sapiens_hsa049240.54196336
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54085416
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.53951546
128Inositol phosphate metabolism_Homo sapiens_hsa005620.52957798
129Melanoma_Homo sapiens_hsa052180.52893767
130Dilated cardiomyopathy_Homo sapiens_hsa054140.52406744
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52141936
132Propanoate metabolism_Homo sapiens_hsa006400.50847170
133FoxO signaling pathway_Homo sapiens_hsa040680.48423170
134Folate biosynthesis_Homo sapiens_hsa007900.48413562
135Glucagon signaling pathway_Homo sapiens_hsa049220.48316532
136Gap junction_Homo sapiens_hsa045400.48088473
137Prolactin signaling pathway_Homo sapiens_hsa049170.47850319
138Rap1 signaling pathway_Homo sapiens_hsa040150.47780759
139Herpes simplex infection_Homo sapiens_hsa051680.47295140
140Apoptosis_Homo sapiens_hsa042100.46535027
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46457151
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.45493634
143RNA degradation_Homo sapiens_hsa030180.44966433
144Arachidonic acid metabolism_Homo sapiens_hsa005900.44744058
145ErbB signaling pathway_Homo sapiens_hsa040120.44739511
146Fructose and mannose metabolism_Homo sapiens_hsa000510.42510253

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