MAP3K7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.17041383
2establishment of integrated proviral latency (GO:0075713)4.84433475
3sister chromatid segregation (GO:0000819)4.68054729
4histone H3-K4 trimethylation (GO:0080182)4.36773626
5DNA topological change (GO:0006265)4.32450330
6DNA ligation (GO:0006266)4.26007725
7non-recombinational repair (GO:0000726)4.25089116
8double-strand break repair via nonhomologous end joining (GO:0006303)4.25089116
9mitotic sister chromatid segregation (GO:0000070)4.07272309
10gap junction assembly (GO:0016264)3.85591473
11mitotic metaphase plate congression (GO:0007080)3.80942404
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.77198735
13epithelial cell-cell adhesion (GO:0090136)3.66847195
14mitotic sister chromatid cohesion (GO:0007064)3.66223052
15pre-miRNA processing (GO:0031054)3.65336501
16mitotic spindle checkpoint (GO:0071174)3.63915955
17negative regulation of chromosome segregation (GO:0051985)3.63655441
18negative regulation of mitotic sister chromatid separation (GO:2000816)3.63451051
19negative regulation of sister chromatid segregation (GO:0033046)3.63451051
20negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.63451051
21negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.63451051
22negative regulation of mitotic sister chromatid segregation (GO:0033048)3.63451051
23spindle checkpoint (GO:0031577)3.63069658
24CENP-A containing nucleosome assembly (GO:0034080)3.62576784
25chromatin remodeling at centromere (GO:0031055)3.59097974
26protein localization to chromosome, centromeric region (GO:0071459)3.56248210
27establishment of viral latency (GO:0019043)3.56015197
28protein localization to kinetochore (GO:0034501)3.55889435
29metaphase plate congression (GO:0051310)3.54018122
30mitotic spindle assembly checkpoint (GO:0007094)3.53836335
31regulation of chromosome segregation (GO:0051983)3.53764417
32spindle assembly checkpoint (GO:0071173)3.50578845
33regulation of centriole replication (GO:0046599)3.49440852
34regulation of mitotic sister chromatid separation (GO:0010965)3.49210630
35regulation of mitotic sister chromatid segregation (GO:0033047)3.49210630
36regulation of sister chromatid segregation (GO:0033045)3.49210630
37mitotic nuclear envelope disassembly (GO:0007077)3.49115611
38regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48648331
39regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48648331
40regulation of DNA endoreduplication (GO:0032875)3.47777265
41hippo signaling (GO:0035329)3.44416782
42NLS-bearing protein import into nucleus (GO:0006607)3.44082939
43heterochromatin organization (GO:0070828)3.40934131
44nuclear pore complex assembly (GO:0051292)3.39957222
45formation of translation preinitiation complex (GO:0001731)3.36531767
46membrane disassembly (GO:0030397)3.35621767
47nuclear envelope disassembly (GO:0051081)3.35621767
48transcytosis (GO:0045056)3.35494028
49mitotic G2/M transition checkpoint (GO:0044818)3.35224850
50negative regulation of fibroblast apoptotic process (GO:2000270)3.30188983
51DNA strand elongation involved in DNA replication (GO:0006271)3.29590254
52DNA strand elongation (GO:0022616)3.28445904
53establishment of chromosome localization (GO:0051303)3.28297052
54negative regulation of DNA recombination (GO:0045910)3.26528022
55cytoplasmic mRNA processing body assembly (GO:0033962)3.26440314
56DNA duplex unwinding (GO:0032508)3.21708297
57insulin-like growth factor receptor signaling pathway (GO:0048009)3.19562672
58ribosome assembly (GO:0042255)3.18724198
59nuclear pore organization (GO:0006999)3.18136804
60DNA replication-independent nucleosome assembly (GO:0006336)3.15968076
61DNA replication-independent nucleosome organization (GO:0034724)3.15968076
62DNA geometric change (GO:0032392)3.14464813
63protein localization to chromosome (GO:0034502)3.14220620
64V(D)J recombination (GO:0033151)3.14128582
65ATP-dependent chromatin remodeling (GO:0043044)3.13215458
66kinetochore organization (GO:0051383)3.10899000
67mitotic G2 DNA damage checkpoint (GO:0007095)3.08946579
68histone exchange (GO:0043486)3.06232695
69DNA replication initiation (GO:0006270)3.05512075
70mitotic recombination (GO:0006312)3.03612506
71cellular response to fluid shear stress (GO:0071498)3.01211562
72positive regulation of chromosome segregation (GO:0051984)2.99034103
73negative regulation of fatty acid transport (GO:2000192)2.98792718
74resolution of meiotic recombination intermediates (GO:0000712)2.97220878
75regulation of DNA damage checkpoint (GO:2000001)2.96798134
76regulation of spindle organization (GO:0090224)2.93437565
77chromosome segregation (GO:0007059)2.91026909
78nucleobase biosynthetic process (GO:0046112)2.89886967
79positive regulation of histone deacetylation (GO:0031065)2.89192806
80response to X-ray (GO:0010165)2.87526133
81cell fate commitment involved in formation of primary germ layer (GO:0060795)2.87104495
82regulation of mitotic spindle checkpoint (GO:1903504)2.86966379
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86966379
84somatic cell DNA recombination (GO:0016444)2.85281913
85somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.85281913
86sister chromatid cohesion (GO:0007062)2.83904012
87regulation of centrosome cycle (GO:0046605)2.82835219
88monoubiquitinated protein deubiquitination (GO:0035520)2.82797287
89paraxial mesoderm development (GO:0048339)2.82731239
90telomere maintenance via semi-conservative replication (GO:0032201)2.82477030
91somatic recombination of immunoglobulin gene segments (GO:0016447)2.81680480
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.81473728
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.81473728
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.81473728
95peptidyl-lysine trimethylation (GO:0018023)2.81096071
96negative regulation of thymocyte apoptotic process (GO:0070244)2.80931600
97regulation of gamma-delta T cell differentiation (GO:0045586)2.80131900
98regulation of mitotic spindle organization (GO:0060236)2.79888785
99regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.79350255
100peptidyl-lysine dimethylation (GO:0018027)2.78798034
101plasma membrane repair (GO:0001778)2.78629424
102positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78425311
103positive regulation of Rho protein signal transduction (GO:0035025)2.78237030
104regulation of sister chromatid cohesion (GO:0007063)2.78112826
105dosage compensation (GO:0007549)2.78074506
106COPI coating of Golgi vesicle (GO:0048205)2.77889568
107Golgi transport vesicle coating (GO:0048200)2.77889568
108lens fiber cell development (GO:0070307)2.76767765
109regulation of translational fidelity (GO:0006450)2.76565601
110negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.74066931
111peptidyl-arginine N-methylation (GO:0035246)2.74028696
112peptidyl-arginine methylation (GO:0018216)2.74028696
113histone H2B ubiquitination (GO:0033523)2.73620449
114positive regulation of SMAD protein import into nucleus (GO:0060391)2.73578353
115regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.72910929
116mRNA stabilization (GO:0048255)2.72698141
117RNA stabilization (GO:0043489)2.72698141
118regulation of translational termination (GO:0006449)2.72696099
119cell migration involved in sprouting angiogenesis (GO:0002042)2.72206864
120regulation of interleukin-12 biosynthetic process (GO:0045075)2.71418502
121regulation of NFAT protein import into nucleus (GO:0051532)2.71383784
122glucocorticoid receptor signaling pathway (GO:0042921)2.68359909
123embryonic viscerocranium morphogenesis (GO:0048703)2.66582186
124regulation of RNA export from nucleus (GO:0046831)2.66477782
125adherens junction assembly (GO:0034333)2.65876999
126regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.64763203
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64561894
128positive regulation of histone H3-K4 methylation (GO:0051571)2.64106719
129gastrulation with mouth forming second (GO:0001702)2.63953207
130cell adhesion mediated by integrin (GO:0033627)2.56097318
131negative regulation of histone methylation (GO:0031061)2.54144173
132striated muscle atrophy (GO:0014891)2.53847467
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.52837189
134response to laminar fluid shear stress (GO:0034616)2.50991087
135positive regulation of glycogen biosynthetic process (GO:0045725)2.50537500
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50460081
137growth hormone receptor signaling pathway (GO:0060396)2.50057157
138establishment of endothelial barrier (GO:0061028)2.49502636
139regulation of fatty acid beta-oxidation (GO:0031998)2.48909385
140regulation of SMAD protein import into nucleus (GO:0060390)2.47651959
141embryonic foregut morphogenesis (GO:0048617)2.46197861
142dorsal/ventral axis specification (GO:0009950)2.46156153
143skeletal muscle adaptation (GO:0043501)2.45338063
1444-hydroxyproline metabolic process (GO:0019471)2.44820888
145pore complex assembly (GO:0046931)2.44278819
146cardiac myofibril assembly (GO:0055003)2.44076088
147midgut development (GO:0007494)2.43639642
148complement activation, alternative pathway (GO:0006957)2.42919644
149negative regulation of cell size (GO:0045792)2.38862391
150epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38478757
151negative regulation of DNA repair (GO:0045738)2.37695866
152regulation of gamma-delta T cell activation (GO:0046643)2.35864634
153cytoskeletal anchoring at plasma membrane (GO:0007016)2.35478803
154response to fluid shear stress (GO:0034405)2.34240168
155histone H3-K4 methylation (GO:0051568)2.32037174
156regulation of nucleobase-containing compound transport (GO:0032239)2.31495035
157peptidyl-lysine methylation (GO:0018022)2.30955307
158regulation of integrin-mediated signaling pathway (GO:2001044)2.30294072
159negative regulation of cardiac muscle tissue growth (GO:0055022)2.29617568
160negative regulation of heart growth (GO:0061117)2.29617568
161axis elongation (GO:0003401)2.28906242
162detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.28274053
163histone H3-K9 demethylation (GO:0033169)2.27782638
164corticosteroid receptor signaling pathway (GO:0031958)2.27588325
165heart morphogenesis (GO:0003007)2.27252541
166regulation of hippo signaling (GO:0035330)2.26173192
167blood vessel endothelial cell migration (GO:0043534)2.25757290
168behavioral response to nicotine (GO:0035095)2.25395532
169regulation of helicase activity (GO:0051095)2.23968307
170glial cell proliferation (GO:0014009)2.23525840
171maternal placenta development (GO:0001893)2.23290313
172alternative mRNA splicing, via spliceosome (GO:0000380)2.23213713
173morphogenesis of an epithelial sheet (GO:0002011)2.21850657
174polarized epithelial cell differentiation (GO:0030859)2.21629624
175protein localization to endosome (GO:0036010)2.19164038
176coronary vasculature morphogenesis (GO:0060977)2.17591236
177apoptotic cell clearance (GO:0043277)2.17183196
178embryonic skeletal joint morphogenesis (GO:0060272)2.16893351
179mitotic chromosome condensation (GO:0007076)2.14485405
180embryonic retina morphogenesis in camera-type eye (GO:0060059)2.14328884
181focal adhesion assembly (GO:0048041)2.14015806
182cell-substrate adherens junction assembly (GO:0007045)2.14015806
183axon extension involved in axon guidance (GO:0048846)2.13448579
184neuron projection extension involved in neuron projection guidance (GO:1902284)2.13448579
185negative regulation of fatty acid biosynthetic process (GO:0045717)2.13431161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.54692894
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.52660746
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.49488270
4E2F7_22180533_ChIP-Seq_HELA_Human4.08745798
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.80670240
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.64785219
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78029564
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75404133
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.69902305
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65785759
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.53933782
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50395551
13CLOCK_20551151_ChIP-Seq_293T_Human2.42060202
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37745773
15* ELK1_19687146_ChIP-ChIP_HELA_Human2.35881532
16* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32307741
17MYC_22102868_ChIP-Seq_BL_Human2.29481794
18ZNF263_19887448_ChIP-Seq_K562_Human2.17483976
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.16848196
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.06968463
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05431492
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00351416
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99355202
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.97736004
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.97528305
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95853884
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93823528
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89529458
29* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88827712
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86305093
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85216139
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84079483
33KDM2B_26808549_Chip-Seq_DND41_Human1.82343396
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81310878
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80005129
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78353860
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78240731
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75675060
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75547652
40TCF7_22412390_ChIP-Seq_EML_Mouse1.75002893
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74505790
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73155009
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71748245
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71688401
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71471517
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70083736
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.69940414
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68058459
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.67938399
50* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67275782
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66701913
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65577645
53* EWS_26573619_Chip-Seq_HEK293_Human1.65501279
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.64175777
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63005715
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62319802
57* FUS_26573619_Chip-Seq_HEK293_Human1.60396509
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59986799
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59934795
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58529868
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57802736
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57675029
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.57589094
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55165613
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54869662
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52120807
67* GABP_17652178_ChIP-ChIP_JURKAT_Human1.52042838
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49302923
69TP53_16413492_ChIP-PET_HCT116_Human1.46799551
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.45023516
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44841787
72VDR_23849224_ChIP-Seq_CD4+_Human1.44299052
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.43954582
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43791192
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42781550
76* EST1_17652178_ChIP-ChIP_JURKAT_Human1.40662784
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40471158
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40300368
79DCP1A_22483619_ChIP-Seq_HELA_Human1.40254368
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39266076
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39224008
82* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.39150339
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38502901
84* ATF3_27146783_Chip-Seq_COLON_Human1.37065365
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.36732075
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.36031408
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34580024
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34306292
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33753406
90BRD4_25478319_ChIP-Seq_HGPS_Human1.33712172
91TAF15_26573619_Chip-Seq_HEK293_Human1.32775727
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32701928
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32701151
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.30429502
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29758402
96AR_21909140_ChIP-Seq_LNCAP_Human1.28580933
97CHD1_26751641_Chip-Seq_LNCaP_Human1.27038584
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25995952
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25666512
100ISL1_27105846_Chip-Seq_CPCs_Mouse1.25012815
101* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24683617
102* FOXP3_21729870_ChIP-Seq_TREG_Human1.24009340
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23959565
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23959565
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23959565
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21916682
107NANOG_16153702_ChIP-ChIP_HESCs_Human1.21526024
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20502898
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19223700
110* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19010316
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18273163
112NCOR1_26117541_ChIP-Seq_K562_Human1.17976757
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.15981085
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15907644
115CREB1_26743006_Chip-Seq_LNCaP_Human1.15539002
116* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14356476
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13949829
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13949829
119KDM2B_26808549_Chip-Seq_K562_Human1.13813365
120TCF4_18268006_ChIP-ChIP_LS174T_Human1.13349704
121* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12020482
122ESR2_21235772_ChIP-Seq_MCF-7_Human1.11536655
123UBF1/2_26484160_Chip-Seq_HMECs_Human1.10298006
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10260336
125* TTF2_22483619_ChIP-Seq_HELA_Human1.09728938
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09324429
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09139592
128BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08946696
129* TBX20_22080862_ChIP-Seq_HEART_Mouse1.08799957
130* TBX20_22328084_ChIP-Seq_HEART_Mouse1.08799957
131PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08022916
132GATA6_25053715_ChIP-Seq_YYC3_Human1.07240896
133TP63_19390658_ChIP-ChIP_HaCaT_Human1.07183378
134VDR_21846776_ChIP-Seq_THP-1_Human1.07150450
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06871926
136RACK7_27058665_Chip-Seq_MCF-7_Human1.06163510
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05291880
138MAF_26560356_Chip-Seq_TH1_Human1.05170534
139SOX2_16153702_ChIP-ChIP_HESCs_Human1.04713466
140ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04549325
141TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04442326
142UTX_26944678_Chip-Seq_JUKART_Human1.04403264
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04241583
144* XRN2_22483619_ChIP-Seq_HELA_Human1.03908813
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02753715
146STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02111144
147* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01844882
148MYC_18940864_ChIP-ChIP_HL60_Human0.99486451
149EP300_21415370_ChIP-Seq_HL-1_Mouse0.99368580
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99155364
151SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98960405
152* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98929578
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98846175
154SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98781785
155* SOX9_26525672_Chip-Seq_HEART_Mouse0.98391288
156RUNX1_27514584_Chip-Seq_MCF-7_Human0.98122146
157PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97495256
158THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95247208
159ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94756105
160SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94467151
161NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94170188
162E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93209041
163FLI1_27457419_Chip-Seq_LIVER_Mouse0.92557658
164* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91511037
165* ETS1_20019798_ChIP-Seq_JURKAT_Human0.90109679
166* GABP_19822575_ChIP-Seq_HepG2_Human0.87788105
167TFEB_21752829_ChIP-Seq_HELA_Human0.87641381
168NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87043811
169SOX17_20123909_ChIP-Seq_XEN_Mouse0.85861030
170NANOG_21062744_ChIP-ChIP_HESCs_Human0.85789513
171EZH2_27294783_Chip-Seq_NPCs_Mouse0.84958872
172TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82260755
173TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81328001
174CIITA_25753668_ChIP-Seq_RAJI_Human0.80618308
175* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80459253
176CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80387059
177GATA1_22025678_ChIP-Seq_K562_Human0.79467606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.13935002
2MP0008057_abnormal_DNA_replication3.87256410
3MP0010094_abnormal_chromosome_stability3.66288478
4MP0010234_abnormal_vibrissa_follicle3.28622589
5MP0003111_abnormal_nucleus_morphology3.15382859
6MP0004957_abnormal_blastocyst_morpholog3.02002701
7MP0002102_abnormal_ear_morphology2.98137053
8MP0003693_abnormal_embryo_hatching2.85701707
9MP0003077_abnormal_cell_cycle2.78850662
10MP0002009_preneoplasia2.74792690
11MP0003566_abnormal_cell_adhesion2.71376189
12MP0010352_gastrointestinal_tract_polyps2.59624414
13MP0008932_abnormal_embryonic_tissue2.58803272
14MP0009697_abnormal_copulation2.58323803
15MP0008438_abnormal_cutaneous_collagen2.52921465
16MP0008058_abnormal_DNA_repair2.50724788
17MP0009053_abnormal_anal_canal2.50252184
18MP0003890_abnormal_embryonic-extraembry2.44919126
19MP0005076_abnormal_cell_differentiation2.33622826
20MP0008007_abnormal_cellular_replicative2.29505578
21MP0000537_abnormal_urethra_morphology2.08589221
22* MP0003300_gastrointestinal_ulcer2.07021914
23MP0000733_abnormal_muscle_development2.01081873
24MP0003941_abnormal_skin_development1.95340040
25MP0001293_anophthalmia1.93428673
26MP0004185_abnormal_adipocyte_glucose1.88972067
27MP0005275_abnormal_skin_tensile1.85027502
28MP0000428_abnormal_craniofacial_morphol1.68883471
29MP0003221_abnormal_cardiomyocyte_apopto1.65703234
30MP0004233_abnormal_muscle_weight1.62551737
31MP0002396_abnormal_hematopoietic_system1.58454026
32MP0003567_abnormal_fetal_cardiomyocyte1.57580513
33MP0002877_abnormal_melanocyte_morpholog1.56058717
34MP0004197_abnormal_fetal_growth/weight/1.55624435
35MP0005503_abnormal_tendon_morphology1.54835019
36MP0003937_abnormal_limbs/digits/tail_de1.52969110
37MP0003283_abnormal_digestive_organ1.52771601
38MP0005623_abnormal_meninges_morphology1.52603565
39MP0003453_abnormal_keratinocyte_physiol1.51832940
40MP0004264_abnormal_extraembryonic_tissu1.51715862
41MP0010307_abnormal_tumor_latency1.51414852
42MP0010678_abnormal_skin_adnexa1.50868285
43MP0002233_abnormal_nose_morphology1.50864017
44MP0002166_altered_tumor_susceptibility1.48823764
45MP0001286_abnormal_eye_development1.46994618
46* MP0010630_abnormal_cardiac_muscle1.46788454
47MP0003115_abnormal_respiratory_system1.46094593
48MP0001849_ear_inflammation1.45291702
49* MP0003252_abnormal_bile_duct1.40085251
50MP0006054_spinal_hemorrhage1.39993880
51MP0003091_abnormal_cell_migration1.37219954
52MP0004087_abnormal_muscle_fiber1.36157920
53* MP0002080_prenatal_lethality1.33931913
54MP0000569_abnormal_digit_pigmentation1.33871494
55MP0003045_fibrosis1.30057196
56* MP0002086_abnormal_extraembryonic_tissu1.27854965
57MP0002088_abnormal_embryonic_growth/wei1.23322025
58MP0002006_tumorigenesis1.23233234
59MP0005666_abnormal_adipose_tissue1.22164369
60MP0003984_embryonic_growth_retardation1.21651457
61* MP0003935_abnormal_craniofacial_develop1.21472466
62MP0004084_abnormal_cardiac_muscle1.21136458
63MP0010030_abnormal_orbit_morphology1.19493794
64MP0004272_abnormal_basement_membrane1.17934856
65MP0002084_abnormal_developmental_patter1.16211126
66MP0002896_abnormal_bone_mineralization1.13247212
67MP0002092_abnormal_eye_morphology1.12994658
68MP0005501_abnormal_skin_physiology1.12488845
69MP0001661_extended_life_span1.11117604
70MP0003121_genomic_imprinting1.11093801
71MP0001915_intracranial_hemorrhage1.10748456
72MP0005187_abnormal_penis_morphology1.10559250
73MP0001672_abnormal_embryogenesis/_devel1.10118478
74MP0005380_embryogenesis_phenotype1.10118478
75MP0009384_cardiac_valve_regurgitation1.09697774
76MP0003385_abnormal_body_wall1.09402883
77* MP0002925_abnormal_cardiovascular_devel1.09337428
78MP0002697_abnormal_eye_size1.07490018
79MP0009278_abnormal_bone_marrow1.06987767
80MP0000377_abnormal_hair_follicle1.06446513
81MP0001730_embryonic_growth_arrest1.05108755
82MP0001299_abnormal_eye_distance/1.05077853
83MP0009672_abnormal_birth_weight1.04658524
84MP0009703_decreased_birth_body1.04560915
85MP0005171_absent_coat_pigmentation1.04422204
86MP0001958_emphysema1.04195073
87MP0002098_abnormal_vibrissa_morphology1.03184225
88MP0003303_peritoneal_inflammation1.02228432
89* MP0000313_abnormal_cell_death1.02190998
90MP0003123_paternal_imprinting1.01695636
91MP0010368_abnormal_lymphatic_system1.01317538
92* MP0000266_abnormal_heart_morphology1.00740163
93MP0002060_abnormal_skin_morphology1.00424672
94MP0000467_abnormal_esophagus_morphology1.00241637
95* MP0002085_abnormal_embryonic_tissue0.99824978
96MP0005023_abnormal_wound_healing0.99795984
97* MP0000432_abnormal_head_morphology0.99536208
98MP0002132_abnormal_respiratory_system0.98841941
99MP0001243_abnormal_dermal_layer0.98832115
100MP0000383_abnormal_hair_follicle0.97749030
101MP0000749_muscle_degeneration0.97586053
102MP0006292_abnormal_olfactory_placode0.96537293
103* MP0002111_abnormal_tail_morphology0.95954937
104MP0004130_abnormal_muscle_cell0.95543336
105* MP0000350_abnormal_cell_proliferation0.94424694
106MP0002269_muscular_atrophy0.93366308
107MP0003786_premature_aging0.93228105
108MP0005248_abnormal_Harderian_gland0.92247416
109MP0003122_maternal_imprinting0.92042073
110* MP0001697_abnormal_embryo_size0.91761938
111MP0000750_abnormal_muscle_regeneration0.91134051
112MP0003119_abnormal_digestive_system0.88446908
113MP0002114_abnormal_axial_skeleton0.88025705
114MP0002932_abnormal_joint_morphology0.87911833
115MP0002796_impaired_skin_barrier0.87488185
116MP0003942_abnormal_urinary_system0.87319295
117* MP0003861_abnormal_nervous_system0.86809198
118MP0003279_aneurysm0.86797938
119MP0005375_adipose_tissue_phenotype0.86734554
120MP0005621_abnormal_cell_physiology0.86714476
121* MP0000767_abnormal_smooth_muscle0.86393921
122MP0006072_abnormal_retinal_apoptosis0.86025536
123MP0002139_abnormal_hepatobiliary_system0.84442008
124* MP0002128_abnormal_blood_circulation0.84200800
125MP0004134_abnormal_chest_morphology0.84023785
126MP0005384_cellular_phenotype0.83845576
127MP0002168_other_aberrant_phenotype0.82464526
128MP0004808_abnormal_hematopoietic_stem0.82086890
129MP0005391_vision/eye_phenotype0.81826417
130MP0001188_hyperpigmentation0.81279236
131MP0002751_abnormal_autonomic_nervous0.81235732
132MP0002108_abnormal_muscle_morphology0.81157762
133MP0002177_abnormal_outer_ear0.80878227
134MP0003755_abnormal_palate_morphology0.80744270
135MP0005257_abnormal_intraocular_pressure0.80501797
136MP0005085_abnormal_gallbladder_physiolo0.79749973
137MP0003828_pulmonary_edema0.78740766
138MP0003315_abnormal_perineum_morphology0.78206744
139MP0006035_abnormal_mitochondrial_morpho0.77930527
140MP0008877_abnormal_DNA_methylation0.76172661
141MP0005197_abnormal_uvea_morphology0.75966630
142MP0009250_abnormal_appendicular_skeleto0.75941164
143MP0005508_abnormal_skeleton_morphology0.75847176
144MP0003787_abnormal_imprinting0.73618690
145MP0002081_perinatal_lethality0.73166489
146MP0001177_atelectasis0.72124881
147MP0000049_abnormal_middle_ear0.71955104
148MP0008770_decreased_survivor_rate0.71250511
149MP0008789_abnormal_olfactory_epithelium0.70861638
150MP0002109_abnormal_limb_morphology0.69338071
151* MP0002019_abnormal_tumor_incidence0.68699990

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.02116863
2Volvulus (HP:0002580)3.87781113
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72077810
4Shoulder girdle muscle weakness (HP:0003547)3.63383566
5Shallow orbits (HP:0000586)3.32666527
6Pelvic girdle muscle weakness (HP:0003749)3.28937136
7Abnormality of the hip-girdle musculature (HP:0001445)3.25917531
8Abnormality of the musculature of the pelvis (HP:0001469)3.25917531
9Medulloblastoma (HP:0002885)3.19395470
10Rhabdomyosarcoma (HP:0002859)3.13862597
11Protrusio acetabuli (HP:0003179)3.12954069
12Abnormality of chromosome stability (HP:0003220)3.09089030
13Nephroblastoma (Wilms tumor) (HP:0002667)3.03193639
14Macroorchidism (HP:0000053)2.98992507
15Embryonal renal neoplasm (HP:0011794)2.94551777
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91443661
17Short 4th metacarpal (HP:0010044)2.91443661
18Papillary thyroid carcinoma (HP:0002895)2.90822373
19Cerebral aneurysm (HP:0004944)2.83758517
20Mitral valve prolapse (HP:0001634)2.81769668
21Abnormal lung lobation (HP:0002101)2.75348698
22Abnormality of the 4th metacarpal (HP:0010012)2.67619516
23Increased nuchal translucency (HP:0010880)2.67344982
24Deep venous thrombosis (HP:0002625)2.65709811
25Premature rupture of membranes (HP:0001788)2.64732760
26Exostoses (HP:0100777)2.56939733
27Subacute progressive viral hepatitis (HP:0006572)2.56090101
28Deep philtrum (HP:0002002)2.53937372
29Deviation of the thumb (HP:0009603)2.53134383
30Proximal placement of thumb (HP:0009623)2.50261477
31Lymphangioma (HP:0100764)2.40241325
32Ankle contracture (HP:0006466)2.39958316
33Supernumerary spleens (HP:0009799)2.37811465
34Meckel diverticulum (HP:0002245)2.33103648
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.31513463
36Aortic aneurysm (HP:0004942)2.30162809
37Hypoplastic pelvis (HP:0008839)2.29585332
38Obsessive-compulsive behavior (HP:0000722)2.28639674
39Vertebral clefting (HP:0008428)2.28202184
40Thyroid carcinoma (HP:0002890)2.27945402
41Dilatation of the ascending aorta (HP:0005111)2.27040312
42Hematochezia (HP:0002573)2.24229853
43Abnormality of the ileum (HP:0001549)2.24054656
44Small intestinal stenosis (HP:0012848)2.23064537
45Duodenal stenosis (HP:0100867)2.23064537
46Intestinal atresia (HP:0011100)2.19696258
47Limb-girdle muscle weakness (HP:0003325)2.16864489
48Asymmetry of the thorax (HP:0001555)2.16695382
49Increased connective tissue (HP:0009025)2.15091262
50Long clavicles (HP:0000890)2.14426690
51Breech presentation (HP:0001623)2.13076295
52Hyperacusis (HP:0010780)2.12723788
53Neonatal short-limb short stature (HP:0008921)2.10576146
54Myelodysplasia (HP:0002863)2.09768231
55Renal duplication (HP:0000075)2.08818303
56Abnormal auditory evoked potentials (HP:0006958)2.07579178
57Myocardial infarction (HP:0001658)2.06451781
58Colon cancer (HP:0003003)2.05744184
59Renovascular hypertension (HP:0100817)2.04393836
60Scanning speech (HP:0002168)2.03874347
61Broad metatarsal (HP:0001783)2.03368387
62Pseudobulbar signs (HP:0002200)2.03235194
63Abnormality of the lower motor neuron (HP:0002366)2.02017082
64Cutis marmorata (HP:0000965)2.01746482
65Neoplasm of striated muscle (HP:0009728)2.01001602
66Neoplasm of the colon (HP:0100273)2.00617072
67Abnormality of the duodenum (HP:0002246)1.99563313
68Truncal obesity (HP:0001956)1.99359221
69Overlapping toe (HP:0001845)1.98843359
70Difficulty running (HP:0009046)1.97966670
71Aneurysm (HP:0002617)1.97919923
72Short middle phalanx of the 5th finger (HP:0004220)1.97918352
73Ectopic anus (HP:0004397)1.96860662
74Scapular winging (HP:0003691)1.96514821
75Bladder diverticulum (HP:0000015)1.96088215
76Increased density of long bones (HP:0006392)1.94817206
77Deviation of the hallux (HP:0010051)1.94051782
78Hallux valgus (HP:0001822)1.92983667
79Heterotopia (HP:0002282)1.92875086
80Disproportionate tall stature (HP:0001519)1.92859065
81Rectal prolapse (HP:0002035)1.92489578
82Skull defect (HP:0001362)1.92366444
83Hyporeflexia of lower limbs (HP:0002600)1.91851645
84Ulnar bowing (HP:0003031)1.91430725
85Limb-girdle muscle atrophy (HP:0003797)1.89722370
86Aortic dissection (HP:0002647)1.89249360
87Enlarged penis (HP:0000040)1.88929573
88Genu recurvatum (HP:0002816)1.88333842
89Aplastic anemia (HP:0001915)1.88044030
90Anteriorly placed anus (HP:0001545)1.88041953
91Degeneration of anterior horn cells (HP:0002398)1.87292039
92Abnormality of the anterior horn cell (HP:0006802)1.87292039
93Astrocytoma (HP:0009592)1.86042712
94Abnormality of the astrocytes (HP:0100707)1.86042712
95Turricephaly (HP:0000262)1.85733473
96Broad palm (HP:0001169)1.85459966
97Subaortic stenosis (HP:0001682)1.84009581
98Abnormality of the left ventricular outflow tract (HP:0011103)1.84009581
99Type 1 muscle fiber predominance (HP:0003803)1.83976362
100Abnormality of the preputium (HP:0100587)1.83522198
101Fibroma (HP:0010614)1.82381744
102Blepharitis (HP:0000498)1.82024870
103Abnormality of proline metabolism (HP:0010907)1.81871283
104Hydroxyprolinuria (HP:0003080)1.81871283
105Fibrous tissue neoplasm (HP:0012316)1.81766607
106Narrow palate (HP:0000189)1.81195831
107Thin bony cortex (HP:0002753)1.80617041
108Syringomyelia (HP:0003396)1.79989662
109Spinal cord lesions (HP:0100561)1.79989662
110Exercise-induced muscle cramps (HP:0003710)1.79772296
111Pancreatic islet-cell hyperplasia (HP:0004510)1.79502176
112Bowel diverticulosis (HP:0005222)1.79018590
113Calcaneovalgus deformity (HP:0001848)1.78876868
114Broad thumb (HP:0011304)1.77963119
115Hypoplastic ischia (HP:0003175)1.77423949
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.77145230
117Osteolytic defects of the hand bones (HP:0009699)1.77145230
118Spastic diplegia (HP:0001264)1.76929444
119Gastrointestinal carcinoma (HP:0002672)1.76735172
120Malignant gastrointestinal tract tumors (HP:0006749)1.76735172
121Submucous cleft hard palate (HP:0000176)1.76266903
122Long eyelashes (HP:0000527)1.75983994
123Right ventricular cardiomyopathy (HP:0011663)1.75201970
124Ankyloglossia (HP:0010296)1.74880095
125Neoplasm of the small intestine (HP:0100833)1.74069362
126Large earlobe (HP:0009748)1.73077536
127Cystic hygroma (HP:0000476)1.72243363
128Ovarian neoplasm (HP:0100615)1.71919724
129Missing ribs (HP:0000921)1.71610997
130Ependymoma (HP:0002888)1.71241197
131Trigonocephaly (HP:0000243)1.70049247
132Abnormality of the carotid arteries (HP:0005344)1.68992087
133Abnormality of the calcaneus (HP:0008364)1.67206567
134Bicuspid aortic valve (HP:0001647)1.65679295
135Absent forearm bone (HP:0003953)1.65212174
136Aplasia involving forearm bones (HP:0009822)1.65212174
137Mildly elevated creatine phosphokinase (HP:0008180)1.64771104
138Elfin facies (HP:0004428)1.64632614
139Cortical dysplasia (HP:0002539)1.64613318
140Embryonal neoplasm (HP:0002898)1.64491943
141Hamartoma of the eye (HP:0010568)1.64153098
142Broad ribs (HP:0000885)1.64069854
143Back pain (HP:0003418)1.63962539
144Proximal amyotrophy (HP:0007126)1.63949319
145Relative macrocephaly (HP:0004482)1.63164162
146Cafe-au-lait spot (HP:0000957)1.63026945
147Cervical subluxation (HP:0003308)1.62752341
148Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62381019
149Transitional cell carcinoma of the bladder (HP:0006740)1.62332287
150Abnormality of chromosome segregation (HP:0002916)1.61776986
151Persistence of primary teeth (HP:0006335)1.61655562
152High anterior hairline (HP:0009890)1.61577696
153Absent eyebrow (HP:0002223)1.61243907
154Acute myeloid leukemia (HP:0004808)1.61243221
155Low anterior hairline (HP:0000294)1.60850748
156Thick eyebrow (HP:0000574)1.60500845
157Increased serum pyruvate (HP:0003542)1.59332428
158Rimmed vacuoles (HP:0003805)1.59255070
159Selective tooth agenesis (HP:0001592)1.58558043
160Absent radius (HP:0003974)1.58528099
161Vertebral arch anomaly (HP:0008438)1.58221854
162Smooth philtrum (HP:0000319)1.58190364
163Gastrointestinal atresia (HP:0002589)1.58028465
164Wide anterior fontanel (HP:0000260)1.57287957
165Peritonitis (HP:0002586)1.56858262
166Hypoplastic labia majora (HP:0000059)1.56845102
167Abnormality of the fetal cardiovascular system (HP:0010948)1.56278958
168Abnormal umbilical cord blood vessels (HP:0011403)1.56278958
169Single umbilical artery (HP:0001195)1.56278958
170T lymphocytopenia (HP:0005403)1.56250053
171Abnormality of oral frenula (HP:0000190)1.56170276
172Atrophic scars (HP:0001075)1.55658627
173Facial cleft (HP:0002006)1.55172606
174Visceral angiomatosis (HP:0100761)1.54426581
175Complete atrioventricular canal defect (HP:0001674)1.53994603
176Termporal pattern (HP:0011008)1.53537581
177Insidious onset (HP:0003587)1.53537581
178Abnormality of the peritoneum (HP:0002585)1.53455552
179Abnormality of the fingertips (HP:0001211)1.53246796
180Choanal atresia (HP:0000453)1.52868157
181Limited elbow extension (HP:0001377)1.52317408
182Esophageal varix (HP:0002040)1.52254589
183Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52223355
184Atrophy/Degeneration involving motor neurons (HP:0007373)1.51408254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DMPK4.16751387
2TRIB34.11221241
3PKN23.94610347
4NUAK13.48453597
5CDK123.30096446
6PLK43.29508385
7BUB13.14210244
8SRPK13.08152952
9TTN2.74346453
10TAF12.67141842
11LATS12.65294045
12MAP3K102.43575933
13STK38L2.33737306
14WEE12.32903375
15MKNK12.23092689
16BRSK22.19627828
17TSSK62.15666848
18PDGFRA2.13360486
19PIK3CA2.07153519
20BCR2.06491714
21EEF2K2.00425736
22PLK31.99461954
23SIK11.94435162
24CDK61.91947565
25PTK61.86185567
26MKNK21.85797752
27RIPK11.80815657
28EPHB21.57475697
29PLK21.56902993
30PNCK1.54701220
31PBK1.46799441
32CDK81.45501986
33ILK1.41935784
34MST41.41352907
35CDK41.39618854
36CHEK21.38384104
37EIF2AK31.36241244
38PLK11.33824447
39STK31.33523886
40MTOR1.30112306
41PDGFRB1.29659526
42MAP3K41.29596567
43CAMK1D1.22621661
44BRD41.21526412
45DDR21.21388213
46STK381.21330242
47FGFR21.21226930
48ATR1.16738413
49DYRK31.13085012
50ALK1.10966746
51EIF2AK11.10564863
52MAP3K141.10428331
53RAF11.09552758
54BMX1.09348770
55ATM1.07464295
56ICK1.03967576
57LRRK20.98258478
58ERBB20.98115933
59TAOK10.96821125
60FGFR10.96450279
61VRK10.94531078
62STK100.94444065
63TEC0.94404881
64FGFR30.94085190
65AURKB0.93566774
66YES10.93487042
67CAMK1G0.93233899
68FGFR40.91228603
69NEK20.89809712
70KSR20.89665095
71PAK20.88299570
72TNIK0.87088956
73BRSK10.86911383
74CLK10.86487450
75CDC70.85698537
76PAK40.84309644
77TYRO30.83199988
78PIK3CG0.81149259
79RET0.81049362
80BMPR20.80024623
81DYRK1B0.78967516
82SCYL20.78165644
83EIF2AK20.77771025
84ERN10.76913897
85MAP3K130.76729945
86CDK70.76654844
87FER0.73812105
88CDK30.73528256
89* MAP3K70.72185493
90RPS6KB20.69514005
91STK160.68945240
92JAK10.67449546
93PAK30.64836959
94SGK30.63369575
95PTK20.63060620
96CSNK1G20.61137268
97MAP2K30.60965194
98LATS20.60788671
99MELK0.60535189
100PRKCH0.60091108
101NEK10.57951200
102MAP4K20.57062214
103CSK0.56069662
104STK40.55481330
105AKT30.54974176
106CSNK1G10.54577748
107ERBB40.53673658
108NEK90.53329724
109CDK90.53255040
110MAP3K120.52437743
111TTK0.52014322
112TGFBR10.51252536
113PDK10.50847049
114CDK10.50821749
115TGFBR20.50671402
116CSNK1A1L0.49638865
117EPHB10.49337556
118TRIM280.47365020
119ROCK10.47010564
120CDK190.46942799
121KSR10.46753597
122MAP3K80.46416736
123CSNK1D0.46319706
124CDK180.46261925
125SIK20.46106742
126ZAK0.45849301
127TRPM70.45598003
128CHEK10.45433497
129EPHA30.45177480
130FLT30.44211829
131OBSCN0.44134137
132MAP3K90.43516012
133TAOK30.41206304
134JAK20.40834725
135ITK0.40580801
136PDPK10.40570105
137WNK10.40220250
138CDK150.40212056
139CHUK0.39902461
140AKT20.39507729
141MET0.39503771
142INSR0.39117902
143PRKD10.38923275
144PASK0.38585436
145PIM10.38350916
146CDK140.37691463
147PRKDC0.37598526
148ROCK20.37205579
149CDC42BPA0.36965805
150CDK11A0.36758122
151MAP2K20.36738202
152CSNK1G30.36323110
153MAP2K10.36305164
154RPS6KB10.35948422
155ERBB30.35918810
156TYK20.35563471
157MAPK100.35273369
158MAP3K20.35210832
159GSK3A0.34729541
160CDK20.34418674
161PRKAA10.34015873
162RPS6KA40.32540404

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.59475695
2DNA replication_Homo sapiens_hsa030303.41709450
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.14819631
4Nitrogen metabolism_Homo sapiens_hsa009103.10571555
5Mismatch repair_Homo sapiens_hsa034303.00560119
6Spliceosome_Homo sapiens_hsa030402.75083444
7RNA transport_Homo sapiens_hsa030132.67758002
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26892392
9Fanconi anemia pathway_Homo sapiens_hsa034602.26730037
10* Adherens junction_Homo sapiens_hsa045202.11596441
11Nucleotide excision repair_Homo sapiens_hsa034202.11240655
12Lysine degradation_Homo sapiens_hsa003102.07297537
13Protein export_Homo sapiens_hsa030602.01503363
14Chronic myeloid leukemia_Homo sapiens_hsa052201.91524107
15Endometrial cancer_Homo sapiens_hsa052131.79345575
16Base excision repair_Homo sapiens_hsa034101.77019486
17Basal transcription factors_Homo sapiens_hsa030221.74229170
18Proteoglycans in cancer_Homo sapiens_hsa052051.73931819
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69165319
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62596906
21RNA degradation_Homo sapiens_hsa030181.62084408
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61921650
23MicroRNAs in cancer_Homo sapiens_hsa052061.59928390
24mTOR signaling pathway_Homo sapiens_hsa041501.59870336
25Focal adhesion_Homo sapiens_hsa045101.55340474
26Fatty acid degradation_Homo sapiens_hsa000711.53469637
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51458894
28Small cell lung cancer_Homo sapiens_hsa052221.50348120
29Thyroid cancer_Homo sapiens_hsa052161.46878048
30Hippo signaling pathway_Homo sapiens_hsa043901.45879126
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42488484
32Insulin resistance_Homo sapiens_hsa049311.41751714
33Homologous recombination_Homo sapiens_hsa034401.39011654
34Oocyte meiosis_Homo sapiens_hsa041141.37896496
35Viral myocarditis_Homo sapiens_hsa054161.33927479
36ECM-receptor interaction_Homo sapiens_hsa045121.23762581
37Pancreatic cancer_Homo sapiens_hsa052121.22888076
38Proteasome_Homo sapiens_hsa030501.22567360
39Tight junction_Homo sapiens_hsa045301.20672345
40Basal cell carcinoma_Homo sapiens_hsa052171.18953672
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.18433607
42Arginine biosynthesis_Homo sapiens_hsa002201.17420559
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16570977
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15140756
45Prostate cancer_Homo sapiens_hsa052151.14161978
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10002936
47Dilated cardiomyopathy_Homo sapiens_hsa054141.09975288
48TGF-beta signaling pathway_Homo sapiens_hsa043501.09293404
49Fatty acid metabolism_Homo sapiens_hsa012121.07652940
50Steroid biosynthesis_Homo sapiens_hsa001001.06432772
51Insulin signaling pathway_Homo sapiens_hsa049101.05983421
52Bladder cancer_Homo sapiens_hsa052191.05955237
53Non-small cell lung cancer_Homo sapiens_hsa052231.04221355
54Renal cell carcinoma_Homo sapiens_hsa052111.03874428
55Colorectal cancer_Homo sapiens_hsa052101.01944141
56Amoebiasis_Homo sapiens_hsa051461.01602082
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00930769
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.00618089
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98987561
60Complement and coagulation cascades_Homo sapiens_hsa046100.97031796
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96339008
62Glioma_Homo sapiens_hsa052140.96230365
63Staphylococcus aureus infection_Homo sapiens_hsa051500.94720769
64HTLV-I infection_Homo sapiens_hsa051660.93411558
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92259010
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.91644751
67Butanoate metabolism_Homo sapiens_hsa006500.91026212
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90558190
69Acute myeloid leukemia_Homo sapiens_hsa052210.89645872
70Type II diabetes mellitus_Homo sapiens_hsa049300.88134114
71Viral carcinogenesis_Homo sapiens_hsa052030.87924633
72Pyrimidine metabolism_Homo sapiens_hsa002400.87207640
73Platelet activation_Homo sapiens_hsa046110.86340853
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85185649
75* AMPK signaling pathway_Homo sapiens_hsa041520.84445237
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.83860721
77Shigellosis_Homo sapiens_hsa051310.83098699
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.82607207
79* Toxoplasmosis_Homo sapiens_hsa051450.81907729
80* Wnt signaling pathway_Homo sapiens_hsa043100.81480799
81FoxO signaling pathway_Homo sapiens_hsa040680.80726863
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79926201
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78785717
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77826086
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.77450775
86Notch signaling pathway_Homo sapiens_hsa043300.77121942
87Carbon metabolism_Homo sapiens_hsa012000.76610441
88Dorso-ventral axis formation_Homo sapiens_hsa043200.76107016
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75757327
90Biosynthesis of amino acids_Homo sapiens_hsa012300.73210149
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73162096
92Pathways in cancer_Homo sapiens_hsa052000.73072901
93Tryptophan metabolism_Homo sapiens_hsa003800.71447098
94Hedgehog signaling pathway_Homo sapiens_hsa043400.70944364
95Prolactin signaling pathway_Homo sapiens_hsa049170.70356338
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70325429
97Alcoholism_Homo sapiens_hsa050340.70227285
98PPAR signaling pathway_Homo sapiens_hsa033200.69342561
99RNA polymerase_Homo sapiens_hsa030200.69301085
100Fatty acid biosynthesis_Homo sapiens_hsa000610.66306586
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65842751
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64734002
103ErbB signaling pathway_Homo sapiens_hsa040120.64156818
104* Epstein-Barr virus infection_Homo sapiens_hsa051690.64139461
105Glucagon signaling pathway_Homo sapiens_hsa049220.64066387
106Hepatitis B_Homo sapiens_hsa051610.63214388
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63047435
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62515265
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60918319
110Tyrosine metabolism_Homo sapiens_hsa003500.60475229
111Cell cycle_Homo sapiens_hsa041100.60392072
112Systemic lupus erythematosus_Homo sapiens_hsa053220.59879753
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59377360
114Estrogen signaling pathway_Homo sapiens_hsa049150.58826692
115Pyruvate metabolism_Homo sapiens_hsa006200.58751033
116HIF-1 signaling pathway_Homo sapiens_hsa040660.58348127
117Propanoate metabolism_Homo sapiens_hsa006400.58303684
118One carbon pool by folate_Homo sapiens_hsa006700.57839255
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57572416
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57286437
121B cell receptor signaling pathway_Homo sapiens_hsa046620.56687933
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56408458
123Bile secretion_Homo sapiens_hsa049760.56229675
124* T cell receptor signaling pathway_Homo sapiens_hsa046600.56115486
125VEGF signaling pathway_Homo sapiens_hsa043700.55681082
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.55566137
127Inositol phosphate metabolism_Homo sapiens_hsa005620.54485751
128Selenocompound metabolism_Homo sapiens_hsa004500.54302536
129Melanoma_Homo sapiens_hsa052180.51613639
130mRNA surveillance pathway_Homo sapiens_hsa030150.51199405
131Starch and sucrose metabolism_Homo sapiens_hsa005000.50608756
132N-Glycan biosynthesis_Homo sapiens_hsa005100.49794492
133p53 signaling pathway_Homo sapiens_hsa041150.48343310
134Fatty acid elongation_Homo sapiens_hsa000620.48088661
135Legionellosis_Homo sapiens_hsa051340.44677536
136Gap junction_Homo sapiens_hsa045400.44408383
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44369245
138* Measles_Homo sapiens_hsa051620.41845628
139Axon guidance_Homo sapiens_hsa043600.38837309
140Purine metabolism_Homo sapiens_hsa002300.38749544
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38282684
142Apoptosis_Homo sapiens_hsa042100.37910723
143Circadian rhythm_Homo sapiens_hsa047100.37884540

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