MAP3K7CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.00398204
2neutrophil activation involved in immune response (GO:0002283)7.53163074
3thrombin receptor signaling pathway (GO:0070493)7.43848099
4atrioventricular valve morphogenesis (GO:0003181)6.38169851
5endocardial cushion development (GO:0003197)6.19879152
6regulation of platelet aggregation (GO:0090330)6.04009923
7urate metabolic process (GO:0046415)5.96062428
8drug transmembrane transport (GO:0006855)5.92285203
9lysine catabolic process (GO:0006554)5.74244329
10lysine metabolic process (GO:0006553)5.74244329
11regulation of platelet activation (GO:0010543)5.55743010
12regulation of cardioblast differentiation (GO:0051890)5.44359660
13leukocyte migration involved in inflammatory response (GO:0002523)5.44135316
14aminoglycoside antibiotic metabolic process (GO:0030647)5.43892747
15regulation of integrin-mediated signaling pathway (GO:2001044)5.43080132
16organic cation transport (GO:0015695)5.40859832
17platelet aggregation (GO:0070527)5.24959855
18blood coagulation, intrinsic pathway (GO:0007597)5.22218484
19adenosine receptor signaling pathway (GO:0001973)5.20354628
20positive regulation of endothelial cell differentiation (GO:0045603)5.12135582
21negative regulation of homotypic cell-cell adhesion (GO:0034111)5.02098110
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.94249527
23drug transport (GO:0015893)4.84685380
24phosphate ion transport (GO:0006817)4.82299651
25quaternary ammonium group transport (GO:0015697)4.81183110
26negative regulation of norepinephrine secretion (GO:0010700)4.72348015
27atrial septum morphogenesis (GO:0060413)4.67736660
28basement membrane organization (GO:0071711)4.66835368
29positive regulation of mast cell activation (GO:0033005)4.66766637
30negative regulation of platelet activation (GO:0010544)4.62781694
31negative regulation of thymocyte apoptotic process (GO:0070244)4.61895803
32neutrophil activation (GO:0042119)4.54148550
33lipoxygenase pathway (GO:0019372)4.45828891
34G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.43661452
35negative regulation of heart growth (GO:0061117)4.43589549
36negative regulation of cardiac muscle tissue growth (GO:0055022)4.43589549
37negative regulation of heart rate (GO:0010459)4.41821838
38negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.33903112
39negative regulation of protein localization to cell surface (GO:2000009)4.28306514
40cell migration involved in heart development (GO:0060973)4.23909553
41angiogenesis involved in wound healing (GO:0060055)4.22557727
42regulation of cardioblast proliferation (GO:0003264)4.21173117
43regulation of secondary heart field cardioblast proliferation (GO:0003266)4.21173117
44phosphate ion transmembrane transport (GO:0035435)4.20527953
45pericardium development (GO:0060039)4.16248853
46carnitine transport (GO:0015879)4.16164628
47amino-acid betaine transport (GO:0015838)4.16164628
48response to mercury ion (GO:0046689)4.14086203
49metanephric nephron tubule development (GO:0072234)4.10819737
50metanephric tubule development (GO:0072170)4.10819737
51purinergic nucleotide receptor signaling pathway (GO:0035590)4.10688898
52platelet degranulation (GO:0002576)4.06080270
53positive regulation of macrophage differentiation (GO:0045651)4.04986343
54muscle filament sliding (GO:0030049)4.04040400
55actin-myosin filament sliding (GO:0033275)4.04040400
56cysteine metabolic process (GO:0006534)4.03146857
57positive regulation of cAMP-mediated signaling (GO:0043950)4.00523682
58granulocyte activation (GO:0036230)3.98764445
59regulation of lipoprotein metabolic process (GO:0050746)3.96855378
60polyamine biosynthetic process (GO:0006596)3.95500479
61negative regulation of appetite (GO:0032099)3.86277578
62negative regulation of response to food (GO:0032096)3.86277578
63metanephric nephron epithelium development (GO:0072243)3.85676530
64low-density lipoprotein particle remodeling (GO:0034374)3.81333892
65megakaryocyte development (GO:0035855)3.80652496
66tricarboxylic acid metabolic process (GO:0072350)3.79074938
67regulation of Golgi to plasma membrane protein transport (GO:0042996)3.76967046
68regulation of homotypic cell-cell adhesion (GO:0034110)3.76374537
69renal absorption (GO:0070293)3.75182741
70plasma membrane repair (GO:0001778)3.73982126
71regulation of integrin activation (GO:0033623)3.70788658
72homotypic cell-cell adhesion (GO:0034109)3.68719382
73regulation of MHC class II biosynthetic process (GO:0045346)3.68145574
74fibroblast migration (GO:0010761)3.66496334
75actin-mediated cell contraction (GO:0070252)3.66088410
76aspartate family amino acid catabolic process (GO:0009068)3.64749857
77platelet formation (GO:0030220)3.64260813
78platelet activation (GO:0030168)3.63846739
79negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.61870255
80regulation of skeletal muscle contraction (GO:0014819)3.61737106
81positive regulation of Rho protein signal transduction (GO:0035025)3.60661217
822-oxoglutarate metabolic process (GO:0006103)3.58110494
83cardiac chamber formation (GO:0003207)3.57479780
84positive regulation of receptor recycling (GO:0001921)3.56565699
85excretion (GO:0007588)3.56226192
86cGMP-mediated signaling (GO:0019934)3.52580398
87metanephric epithelium development (GO:0072207)3.52290942
88glyoxylate metabolic process (GO:0046487)3.51498381
89valine metabolic process (GO:0006573)3.50545122
90fusion of sperm to egg plasma membrane (GO:0007342)3.47721899
91purinergic receptor signaling pathway (GO:0035587)3.46312543
92cellular response to vitamin D (GO:0071305)3.45892648
93vitamin D metabolic process (GO:0042359)3.45879882
94positive regulation of systemic arterial blood pressure (GO:0003084)3.44516766
95regulation of macrophage derived foam cell differentiation (GO:0010743)3.43970275
96regulation of endothelial cell differentiation (GO:0045601)3.42693144
97cellular response to vitamin (GO:0071295)3.41797904
98nephron tubule development (GO:0072080)3.37172263
99cell adhesion mediated by integrin (GO:0033627)3.37114862
100positive regulation of blood coagulation (GO:0030194)3.35112820
101positive regulation of hemostasis (GO:1900048)3.35112820
102G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.34732212
103negative regulation of heart contraction (GO:0045822)3.33066527
104termination of G-protein coupled receptor signaling pathway (GO:0038032)3.32419622
105extracellular fibril organization (GO:0043206)3.30832884
106negative regulation of neural precursor cell proliferation (GO:2000178)3.30388896
107negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.28822497
108negative regulation of T-helper cell differentiation (GO:0045623)3.28822497
109regulation of norepinephrine secretion (GO:0014061)3.28661657
110autophagic vacuole fusion (GO:0000046)3.26964430
111heart valve morphogenesis (GO:0003179)3.26219185
112termination of signal transduction (GO:0023021)3.25242959
113positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.24891040
114drug catabolic process (GO:0042737)3.23483950
115sarcomere organization (GO:0045214)3.21395684
116exogenous drug catabolic process (GO:0042738)3.21012643
117branched-chain amino acid metabolic process (GO:0009081)3.17798389
118regulation of mast cell activation (GO:0033003)3.13415671
119negative regulation of T cell apoptotic process (GO:0070233)3.11652465
120pyrimidine nucleoside catabolic process (GO:0046135)3.11418844
121trivalent inorganic anion homeostasis (GO:0072506)3.10286522
122phosphate ion homeostasis (GO:0055062)3.10286522
123beta-amyloid metabolic process (GO:0050435)3.09719674
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07751082
125leukocyte degranulation (GO:0043299)3.07263988
126regulation of memory T cell differentiation (GO:0043380)3.05786099
127phagocytosis, engulfment (GO:0006911)3.04923659
128actin filament-based movement (GO:0030048)3.03326243
129positive regulation of mast cell activation involved in immune response (GO:0033008)3.01764548
130positive regulation of mast cell degranulation (GO:0043306)3.01764548
131long-chain fatty acid biosynthetic process (GO:0042759)3.00372015
132positive regulation of coagulation (GO:0050820)2.99646134
133ventricular septum development (GO:0003281)2.98404214
134regulation of regulatory T cell differentiation (GO:0045589)2.98380712
135negative regulation of calcium ion transport into cytosol (GO:0010523)2.98261261
136renal tubule development (GO:0061326)2.97711134
137skeletal muscle tissue regeneration (GO:0043403)2.97651487
138adenosine metabolic process (GO:0046085)2.96180788
139short-chain fatty acid metabolic process (GO:0046459)2.95158554
140epithelial cell-cell adhesion (GO:0090136)2.95059560
141nonribosomal peptide biosynthetic process (GO:0019184)2.94157204
142peptide catabolic process (GO:0043171)2.93683177
143carnitine transmembrane transport (GO:1902603)2.93615586
144cellular biogenic amine biosynthetic process (GO:0042401)2.91200607
145regulation of mast cell degranulation (GO:0043304)2.91129603
146nephron epithelium development (GO:0072009)2.90674223
147renal filtration (GO:0097205)2.89228264
148fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87535149
149regulation of receptor recycling (GO:0001919)2.87218274
150regulation of female receptivity (GO:0045924)2.87015944
151negative regulation of catecholamine secretion (GO:0033604)2.86669250
152regulation of blood coagulation (GO:0030193)2.85763702
153regulation of hemostasis (GO:1900046)2.85763702
154regulation of mast cell activation involved in immune response (GO:0033006)2.84963139
155negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.84850092
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.84064889
157vesicle targeting (GO:0006903)2.83531229
158negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.83014146
159fibril organization (GO:0097435)2.82345732
160positive regulation of cardiac muscle cell proliferation (GO:0060045)2.81904785
161response to parathyroid hormone (GO:0071107)2.81621523
162mitochondrial calcium ion transport (GO:0006851)2.81252896
163toxin transport (GO:1901998)2.80341943
164sequestering of actin monomers (GO:0042989)2.79037203
165cardiac septum development (GO:0003279)2.78961182
166renal tubule morphogenesis (GO:0061333)2.77844790
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77541645
168plasma membrane fusion (GO:0045026)2.77394728
169high-density lipoprotein particle remodeling (GO:0034375)2.77155353
170fatty acid beta-oxidation (GO:0006635)2.75114815
171negative regulation of protein localization to plasma membrane (GO:1903077)2.73986969
172response to growth hormone (GO:0060416)2.72908841
173regulation of SMAD protein import into nucleus (GO:0060390)2.72737581
174amine biosynthetic process (GO:0009309)2.72345280
175positive regulation of immunoglobulin mediated immune response (GO:0002891)2.72313098
176positive regulation of B cell mediated immunity (GO:0002714)2.72313098
177actin filament depolymerization (GO:0030042)2.70862272
178chondrocyte proliferation (GO:0035988)2.70464693
179glomerular filtration (GO:0003094)2.67652663
180venous blood vessel morphogenesis (GO:0048845)2.66111497
181response to phenylpropanoid (GO:0080184)2.64230284
182carnitine shuttle (GO:0006853)2.62808273
183carnitine metabolic process (GO:0009437)2.61371517
184glutathione biosynthetic process (GO:0006750)2.60608033
185positive regulation of cardiac muscle tissue growth (GO:0055023)2.60047561
186homocysteine metabolic process (GO:0050667)2.59762259
187positive regulation of SMAD protein import into nucleus (GO:0060391)2.58948324
188negative regulation of cardiac muscle tissue development (GO:0055026)2.58861812
189sarcoplasmic reticulum calcium ion transport (GO:0070296)2.57560366
190regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57212964
191pyrimidine ribonucleoside catabolic process (GO:0046133)2.56642945
192cardiac ventricle formation (GO:0003211)2.56614937
193amino-acid betaine metabolic process (GO:0006577)2.55425850
194fatty acid oxidation (GO:0019395)2.54504343
195cellular modified amino acid catabolic process (GO:0042219)2.50369974
196regulation of heart morphogenesis (GO:2000826)2.49688761
197nephron tubule morphogenesis (GO:0072078)2.49102190
198nephron epithelium morphogenesis (GO:0072088)2.49102190
199glomerular basement membrane development (GO:0032836)2.48895594
200lipid oxidation (GO:0034440)2.47945587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.06247881
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.51413984
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.02163072
4SCL_19346495_ChIP-Seq_HPC-7_Human3.73544085
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.72738434
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.55047004
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27872254
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12692993
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.97655970
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.97229215
11GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.92508691
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.74795263
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.71050312
14GATA1_19941826_ChIP-Seq_K562_Human2.66412595
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.65509753
16EZH2_22144423_ChIP-Seq_EOC_Human2.62018964
17LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.58248106
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.55946660
19CLOCK_20551151_ChIP-Seq_293T_Human2.39905988
20GATA2_19941826_ChIP-Seq_K562_Human2.36770997
21GATA1_19941827_ChIP-Seq_MEL_Mouse2.30598109
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26406541
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.23704440
24SPI1_23127762_ChIP-Seq_K562_Human2.20931878
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19118725
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12882924
27GBX2_23144817_ChIP-Seq_PC3_Human2.12155998
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.10359631
29CJUN_26792858_Chip-Seq_BT549_Human2.05223309
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.98783751
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98713185
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93094041
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92989446
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91333064
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.90882871
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.89693776
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.89675400
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86376697
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85119682
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84763052
41HTT_18923047_ChIP-ChIP_STHdh_Human1.84055345
42GATA1_22383799_ChIP-Seq_G1ME_Mouse1.83788405
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.81515023
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.81471142
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.81471142
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78398873
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77860963
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.75770540
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73344167
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70337806
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68585042
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66495180
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66495180
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66043965
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.61593772
56GATA1_22025678_ChIP-Seq_K562_Human1.61196366
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60936730
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.60739169
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60426006
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.59568498
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57702172
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57334232
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56603263
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55353972
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55324781
66MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.54817628
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53909366
68RUNX_20019798_ChIP-Seq_JUKART_Human1.53274417
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49705811
70GATA1_19941827_ChIP-Seq_MEL86_Mouse1.49559627
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48879849
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.47956932
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42970972
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40158094
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36718002
76TP53_16413492_ChIP-PET_HCT116_Human1.36260703
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35861859
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33581695
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30569273
80TAF15_26573619_Chip-Seq_HEK293_Human1.30385389
81TP53_18474530_ChIP-ChIP_U2OS_Human1.28837489
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27445665
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26075280
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25936416
85SOX2_20726797_ChIP-Seq_SW620_Human1.25105077
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.25024334
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.24293746
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24208339
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23857286
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23419058
91SALL4_22934838_ChIP-ChIP_CD34+_Human1.21003372
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18135804
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17478925
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17157032
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16342889
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.15873630
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15741710
98KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.14335382
99RXR_22108803_ChIP-Seq_LS180_Human1.12616441
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11819041
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.11518501
102BRD4_25478319_ChIP-Seq_HGPS_Human1.10793996
103VDR_22108803_ChIP-Seq_LS180_Human1.10082545
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.10017778
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08317508
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07609035
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07370734
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06433601
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06213232
110BCAT_22108803_ChIP-Seq_LS180_Human1.06158481
111IRF8_22096565_ChIP-ChIP_GC-B_Human1.05992610
112TP63_23658742_ChIP-Seq_EP156T_Human1.05347130
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03979475
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03201080
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02795740
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02282553
117AHR_22903824_ChIP-Seq_MCF-7_Human1.01913702
118ISL1_27105846_Chip-Seq_CPCs_Mouse1.01706670
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.01684643
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.00874477
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.00428962
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.99410076
123ETS1_22383799_ChIP-Seq_G1ME_Mouse0.98725908
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98578310
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98422170
126SPI1_20517297_ChIP-Seq_HL60_Human0.98201102
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98008511
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97830579
129SPI1_23547873_ChIP-Seq_NB4_Human0.97499531
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.97150484
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96886315
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96739548
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96739548
134BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95991354
135STAT1_20625510_ChIP-Seq_HELA_Human0.95949223
136SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95431459
137RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94698101
138TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94434855
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94213948
140LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93996715
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93144656
142GATA3_26560356_Chip-Seq_TH2_Human0.92402116
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91910541
144GATA4_25053715_ChIP-Seq_YYC3_Human0.91891114
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91796261
146JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91312735
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91253977
148VDR_24787735_ChIP-Seq_THP-1_Human0.91136388
149GATA3_27048872_Chip-Seq_THYMUS_Human0.91088943
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90972555
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90945434
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89942243
153EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89698415
154SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88866582
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88671905
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88526375
157SMAD4_21799915_ChIP-Seq_A2780_Human0.88445897
158OCT1_27270436_Chip-Seq_PROSTATE_Human0.88381467
159JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88327656
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88311918
161E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87724564
162NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87652753
163SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87251434
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.86410793
165ZNF274_21170338_ChIP-Seq_K562_Hela0.86399471
166GATA3_21878914_ChIP-Seq_MCF-7_Human0.86060645
167MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85980384
168TCF4_18268006_ChIP-ChIP_LS174T_Human0.85810431
169TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85484488
170SMRT_27268052_Chip-Seq_Bcells_Human0.85423684
171P53_22387025_ChIP-Seq_ESCs_Mouse0.84727796
172MYB_26560356_Chip-Seq_TH2_Human0.84181485
173RACK7_27058665_Chip-Seq_MCF-7_Human0.83771732
174AR_25329375_ChIP-Seq_VCAP_Human0.83713608
175CRX_20693478_ChIP-Seq_RETINA_Mouse0.83124434
176CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82525205
177TP53_23651856_ChIP-Seq_MEFs_Mouse0.82284381
178ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81959897
179OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81773795
180Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81654112
181NCOR1_26117541_ChIP-Seq_K562_Human0.81463221
182AR_21909140_ChIP-Seq_LNCAP_Human0.81169516
183CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79964269
184NANOG_19829295_ChIP-Seq_ESCs_Human0.79172297
185SOX2_19829295_ChIP-Seq_ESCs_Human0.79172297
186SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.79062118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.66139928
2MP0008004_abnormal_stomach_pH5.31251846
3MP0003724_increased_susceptibility_to4.06447642
4MP0005360_urolithiasis3.87654668
5MP0005503_abnormal_tendon_morphology3.72303526
6MP0000465_gastrointestinal_hemorrhage3.25082216
7MP0000751_myopathy3.14573275
8MP0004043_abnormal_pH_regulation3.11887170
9MP0001958_emphysema2.97135603
10MP0004510_myositis2.89414782
11MP0005623_abnormal_meninges_morphology2.80619696
12MP0000749_muscle_degeneration2.70519398
13MP0004272_abnormal_basement_membrane2.69965910
14MP0001835_abnormal_antigen_presentation2.57764800
15MP0005332_abnormal_amino_acid2.46176348
16MP0008438_abnormal_cutaneous_collagen2.40787307
17MP0005083_abnormal_biliary_tract2.40230484
18MP0000343_altered_response_to2.35400021
19MP0003303_peritoneal_inflammation2.34570673
20MP0000747_muscle_weakness2.34503525
21MP0004145_abnormal_muscle_electrophysio2.29395904
22MP0009384_cardiac_valve_regurgitation2.27720643
23MP0002736_abnormal_nociception_after2.19603727
24MP0004019_abnormal_vitamin_homeostasis2.10708775
25MP0003566_abnormal_cell_adhesion2.07261480
26MP0009643_abnormal_urine_homeostasis2.06241338
27MP0001765_abnormal_ion_homeostasis2.01025479
28MP0002139_abnormal_hepatobiliary_system1.98739029
29MP0002108_abnormal_muscle_morphology1.97725295
30MP0002138_abnormal_hepatobiliary_system1.97086207
31MP0003705_abnormal_hypodermis_morpholog1.94105379
32MP0005620_abnormal_muscle_contractility1.93823391
33MP0005671_abnormal_response_to1.86803474
34MP0002837_dystrophic_cardiac_calcinosis1.85687567
35MP0000750_abnormal_muscle_regeneration1.82545761
36MP0004084_abnormal_cardiac_muscle1.82028528
37MP0005330_cardiomyopathy1.77893463
38MP0002269_muscular_atrophy1.76633783
39MP0000733_abnormal_muscle_development1.74963429
40MP0001756_abnormal_urination1.74848894
41MP0002148_abnormal_hypersensitivity_rea1.72776247
42MP0004036_abnormal_muscle_relaxation1.71845444
43MP0004087_abnormal_muscle_fiber1.71496001
44MP0005000_abnormal_immune_tolerance1.69791714
45MP0010155_abnormal_intestine_physiology1.69091728
46MP0003195_calcinosis1.68854106
47MP0005167_abnormal_blood-brain_barrier1.68203069
48MP0005275_abnormal_skin_tensile1.66094008
49MP0008872_abnormal_physiological_respon1.64990616
50MP0003638_abnormal_response/metabolism_1.64894881
51MP0003252_abnormal_bile_duct1.63481256
52MP0002136_abnormal_kidney_physiology1.62340246
53MP0003279_aneurysm1.59772249
54MP0005369_muscle_phenotype1.58624933
55MP0003879_abnormal_hair_cell1.57774047
56MP0001851_eye_inflammation1.57183979
57MP0005410_abnormal_fertilization1.56240972
58MP0004233_abnormal_muscle_weight1.56015998
59MP0002106_abnormal_muscle_physiology1.55259991
60MP0003436_decreased_susceptibility_to1.54841874
61MP0003646_muscle_fatigue1.53363394
62MP0003300_gastrointestinal_ulcer1.49949751
63MP0002132_abnormal_respiratory_system1.48415740
64MP0004130_abnormal_muscle_cell1.46028207
65MP0005646_abnormal_pituitary_gland1.45281324
66MP0002398_abnormal_bone_marrow1.43364767
67MP0000249_abnormal_blood_vessel1.42147405
68MP0002972_abnormal_cardiac_muscle1.40865194
69MP0009250_abnormal_appendicular_skeleto1.39977793
70MP0002168_other_aberrant_phenotype1.38997404
71MP0001663_abnormal_digestive_system1.36469482
72MP0002896_abnormal_bone_mineralization1.35305718
73MP0002089_abnormal_postnatal_growth/wei1.35179359
74MP0001533_abnormal_skeleton_physiology1.34551351
75MP0001545_abnormal_hematopoietic_system1.33289764
76MP0005397_hematopoietic_system_phenotyp1.33289764
77MP0001968_abnormal_touch/_nociception1.32688759
78MP0002723_abnormal_immune_serum1.31869166
79MP0008775_abnormal_heart_ventricle1.31148413
80MP0003045_fibrosis1.30734874
81MP0000759_abnormal_skeletal_muscle1.29584262
82MP0001800_abnormal_humoral_immune1.28291984
83MP0003941_abnormal_skin_development1.26428570
84MP0009764_decreased_sensitivity_to1.25723145
85MP0004484_altered_response_of1.25722144
86MP0010368_abnormal_lymphatic_system1.24704874
87MP0005058_abnormal_lysosome_morphology1.23771524
88MP0004947_skin_inflammation1.23254952
89MP0002452_abnormal_antigen_presenting1.22984507
90MP0009763_increased_sensitivity_to1.22712025
91MP0002009_preneoplasia1.21808634
92MP0003091_abnormal_cell_migration1.20560275
93MP0005636_abnormal_mineral_homeostasis1.19807787
94MP0000858_altered_metastatic_potential1.19587147
95MP0001661_extended_life_span1.18325443
96MP0006138_congestive_heart_failure1.16477893
97MP0005508_abnormal_skeleton_morphology1.15938135
98MP0002928_abnormal_bile_duct1.14954057
99MP0004215_abnormal_myocardial_fiber1.14594158
100MP0002295_abnormal_pulmonary_circulatio1.14160937
101MP0003137_abnormal_impulse_conducting1.14006690
102MP0009780_abnormal_chondrocyte_physiolo1.12817699
103MP0002733_abnormal_thermal_nociception1.12750249
104MP0001544_abnormal_cardiovascular_syste1.12485767
105MP0005385_cardiovascular_system_phenoty1.12485767
106MP0000230_abnormal_systemic_arterial1.12263913
107MP0005084_abnormal_gallbladder_morpholo1.11527131
108MP0010329_abnormal_lipoprotein_level1.11270705
109MP0008875_abnormal_xenobiotic_pharmacok1.11179006
110MP0008961_abnormal_basal_metabolism1.09991336
111MP0003385_abnormal_body_wall1.09767414
112MP0002419_abnormal_innate_immunity1.08464674
113MP0003828_pulmonary_edema1.06993449
114MP0003283_abnormal_digestive_organ1.06340980
115MP0002420_abnormal_adaptive_immunity1.05888607
116MP0000013_abnormal_adipose_tissue1.05593325
117MP0001819_abnormal_immune_cell1.03917496
118MP0000689_abnormal_spleen_morphology1.01760046
119MP0010630_abnormal_cardiac_muscle1.01565222
120MP0002429_abnormal_blood_cell1.01505293
121MP0002115_abnormal_skeleton_extremities0.98559452
122MP0003866_abnormal_defecation0.98424339
123MP0001845_abnormal_inflammatory_respons0.97608887
124MP0001790_abnormal_immune_system0.97384022
125MP0005387_immune_system_phenotype0.97384022
126MP0008874_decreased_physiological_sensi0.95349527
127MP0000767_abnormal_smooth_muscle0.95234513
128MP0000685_abnormal_immune_system0.95018824
129MP0010352_gastrointestinal_tract_polyps0.94206268
130MP0005377_hearing/vestibular/ear_phenot0.93465339
131MP0003878_abnormal_ear_physiology0.93465339
132MP0000015_abnormal_ear_pigmentation0.93331399
133MP0000163_abnormal_cartilage_morphology0.92627634
134MP0009765_abnormal_xenobiotic_induced0.92592333
135MP0005023_abnormal_wound_healing0.92484297
136MP0000534_abnormal_ureter_morphology0.92430621
137MP0005025_abnormal_response_to0.91769868
138MP0005666_abnormal_adipose_tissue0.91374212
139MP0009642_abnormal_blood_homeostasis0.91133948
140MP0000716_abnormal_immune_system0.90363319
141MP0003656_abnormal_erythrocyte_physiolo0.90343837
142MP0002722_abnormal_immune_system0.89322832
143MP0004883_abnormal_blood_vessel0.89142266
144MP0000538_abnormal_urinary_bladder0.88925059
145MP0005670_abnormal_white_adipose0.87924213
146MP0002998_abnormal_bone_remodeling0.87347830
147MP0006276_abnormal_autonomic_nervous0.84250743
148MP0001299_abnormal_eye_distance/0.84213370
149MP0003567_abnormal_fetal_cardiomyocyte0.83090409
150MP0005381_digestive/alimentary_phenotyp0.82116868
151MP0005375_adipose_tissue_phenotype0.81302304
152MP0003950_abnormal_plasma_membrane0.80795449
153MP0005257_abnormal_intraocular_pressure0.80078344
154MP0002135_abnormal_kidney_morphology0.79921375
155MP0001664_abnormal_digestion0.79762060
156MP0009333_abnormal_splenocyte_physiolog0.79674919
157MP0006054_spinal_hemorrhage0.76795022
158MP0003075_altered_response_to0.75832668
159MP0002128_abnormal_blood_circulation0.74039806
160MP0001970_abnormal_pain_threshold0.73862460
161MP0000003_abnormal_adipose_tissue0.73005996
162MP0005174_abnormal_tail_pigmentation0.72128358
163MP0005165_increased_susceptibility_to0.71854625
164MP0005319_abnormal_enzyme/_coenzyme0.71495332
165MP0003718_maternal_effect0.70730018
166MP0003183_abnormal_peptide_metabolism0.69739077
167MP0009785_altered_susceptibility_to0.69229629
168MP0009697_abnormal_copulation0.68838056
169MP0001879_abnormal_lymphatic_vessel0.68641353
170MP0005367_renal/urinary_system_phenotyp0.68534977
171MP0000516_abnormal_urinary_system0.68534977
172MP0004142_abnormal_muscle_tone0.62929017
173MP0002118_abnormal_lipid_homeostasis0.60647215

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.83030547
2Petechiae (HP:0000967)9.60582235
3Purpura (HP:0000979)8.75116754
4Epistaxis (HP:0000421)7.75908667
5Gingival bleeding (HP:0000225)6.77734401
6Hyperlipoproteinemia (HP:0010980)5.72143279
7Abnormal platelet function (HP:0011869)5.58435387
8Impaired platelet aggregation (HP:0003540)5.58435387
9Gout (HP:0001997)5.02867629
10Spontaneous hematomas (HP:0007420)4.93564837
11Muscle fiber splitting (HP:0003555)4.82702652
12Increased circulating renin level (HP:0000848)4.55750701
13Metabolic alkalosis (HP:0200114)4.49282632
14Hypokalemic alkalosis (HP:0001949)4.44183230
15Abnormality of chloride homeostasis (HP:0011422)4.41511707
16Aplasia of the musculature (HP:0100854)4.39421108
17Dyschromatopsia (HP:0007641)4.32649935
18Hypomagnesemia (HP:0002917)4.31855842
19Polyuria (HP:0000103)4.18482974
20Increased purine levels (HP:0004368)4.12197544
21Hyperuricemia (HP:0002149)4.12197544
22Hyperactive renin-angiotensin system (HP:0000841)4.05328574
23Abnormal urine output (HP:0012590)3.99207818
24Abnormality of renal excretion (HP:0011036)3.92848709
25Poikilocytosis (HP:0004447)3.90471243
26Conjunctival telangiectasia (HP:0000524)3.89896006
27Acanthocytosis (HP:0001927)3.89321832
28Muscle fiber inclusion bodies (HP:0100299)3.84091814
29Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.77371059
30Abnormal pupillary function (HP:0007686)3.75545009
31Proximal tubulopathy (HP:0000114)3.56687968
32Bruising susceptibility (HP:0000978)3.50553759
33Abnormality of magnesium homeostasis (HP:0004921)3.49711827
34Abnormal drinking behavior (HP:0030082)3.46963223
35Polydipsia (HP:0001959)3.46963223
36Abnormality of the vasculature of the conjunctiva (HP:0008054)3.41831560
37Abnormality of the common coagulation pathway (HP:0010990)3.39545480
38Type 1 muscle fiber predominance (HP:0003803)3.36365678
39Abnormality of purine metabolism (HP:0004352)3.31218134
40Nemaline bodies (HP:0003798)3.29525532
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.26177673
42Tetany (HP:0001281)3.21699360
43Increased density of long bones (HP:0006392)3.18007783
44Ulnar deviation of the wrist (HP:0003049)3.17241148
45Hyporeflexia of lower limbs (HP:0002600)3.13843736
46Round ear (HP:0100830)3.11360345
47Exercise-induced muscle cramps (HP:0003710)3.11049675
48Paralysis (HP:0003470)3.08955376
49Abnormality of lateral ventricle (HP:0030047)2.95709042
50Cardiovascular calcification (HP:0011915)2.95026775
51Hypokalemia (HP:0002900)2.94770605
52Right ventricular cardiomyopathy (HP:0011663)2.93242271
53Distal arthrogryposis (HP:0005684)2.90635398
54Vascular calcification (HP:0004934)2.86275352
55Exercise-induced myalgia (HP:0003738)2.84227708
56Abnormality of the calf musculature (HP:0001430)2.84189904
57Aortic aneurysm (HP:0004942)2.80670145
58Hyperaldosteronism (HP:0000859)2.80442553
59Abnormality of renin-angiotensin system (HP:0000847)2.75354264
60Protrusio acetabuli (HP:0003179)2.74684851
61Hyperglycinuria (HP:0003108)2.73067966
62Hip contracture (HP:0003273)2.72598509
63Abnormality of potassium homeostasis (HP:0011042)2.72452731
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.72192037
65Muscle hypertrophy of the lower extremities (HP:0008968)2.70038255
66Calf muscle hypertrophy (HP:0008981)2.67942034
67Chondrocalcinosis (HP:0000934)2.67243383
68Abnormal auditory evoked potentials (HP:0006958)2.65118489
69Premature rupture of membranes (HP:0001788)2.64894242
70Ketoacidosis (HP:0001993)2.63922004
71Hypercalciuria (HP:0002150)2.63441851
72Abnormality of macrophages (HP:0004311)2.61379203
73Difficulty running (HP:0009046)2.60799659
74Hepatosplenomegaly (HP:0001433)2.55928413
75Stomatitis (HP:0010280)2.55924926
76Renal salt wasting (HP:0000127)2.54124622
77Renal tubular acidosis (HP:0001947)2.52537034
78Increased connective tissue (HP:0009025)2.50636777
79Decreased central vision (HP:0007663)2.48628537
80Metaphyseal cupping (HP:0003021)2.48336221
81Hydroxyprolinuria (HP:0003080)2.48008688
82Abnormality of proline metabolism (HP:0010907)2.48008688
83Alkalosis (HP:0001948)2.47997677
84Abnormality of Sharpey fibers (HP:0100685)2.47374410
85Generalized muscle weakness (HP:0003324)2.45179898
86EMG: myopathic abnormalities (HP:0003458)2.44453817
87Joint hemorrhage (HP:0005261)2.42070508
88Increased IgM level (HP:0003496)2.41183334
89Xanthomatosis (HP:0000991)2.40730602
90Joint swelling (HP:0001386)2.38246564
91Sudden death (HP:0001699)2.37829473
92Hypoplastic left heart (HP:0004383)2.36028930
93Upper limb muscle weakness (HP:0003484)2.35998081
94Anomalous pulmonary venous return (HP:0010772)2.30292922
95Myopathic facies (HP:0002058)2.24933255
96Partial duplication of thumb phalanx (HP:0009944)2.23335772
97Abnormality of iron homeostasis (HP:0011031)2.22309208
98Scapular winging (HP:0003691)2.20391781
99Vascular tortuosity (HP:0004948)2.20158699
100Nausea (HP:0002018)2.19129212
101Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17929040
102Limited hip movement (HP:0008800)2.15621703
103Hypoplastic heart (HP:0001961)2.14945285
104Generalized aminoaciduria (HP:0002909)2.14552632
105Abnormality of glycine metabolism (HP:0010895)2.14409963
106Abnormality of serine family amino acid metabolism (HP:0010894)2.14409963
107Hyperkalemia (HP:0002153)2.13892869
108Tinnitus (HP:0000360)2.13007981
109Cervical subluxation (HP:0003308)2.11808817
110Ketosis (HP:0001946)2.08705431
111Knee flexion contracture (HP:0006380)2.07381288
112Partial duplication of the phalanx of hand (HP:0009999)2.07342786
113Arterial thrombosis (HP:0004420)2.07199386
114Encephalitis (HP:0002383)2.07180206
115Facial shape deformation (HP:0011334)2.06481005
116Potter facies (HP:0002009)2.06481005
117Difficulty climbing stairs (HP:0003551)2.06138404
118Abnormality of the pulmonary veins (HP:0011718)2.05419230
119Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.05235307
1203-Methylglutaconic aciduria (HP:0003535)2.05190144
121Thyroid-stimulating hormone excess (HP:0002925)2.04847788
122Increased variability in muscle fiber diameter (HP:0003557)2.03729253
123Abnormality of skeletal muscle fiber size (HP:0012084)2.03718736
124Aortic dissection (HP:0002647)2.02976658
125Cerebral aneurysm (HP:0004944)2.02480086
126Myoglobinuria (HP:0002913)2.02057970
127Abnormality of the shoulder girdle musculature (HP:0001435)2.01741990
128Thin bony cortex (HP:0002753)2.01361602
129Myocardial infarction (HP:0001658)2.01349377
130Complete atrioventricular canal defect (HP:0001674)2.00867219
131Prolonged bleeding time (HP:0003010)11.4514300
132Menorrhagia (HP:0000132)10.5169498
133Increased mean platelet volume (HP:0011877)10.4161270
134Ventricular fibrillation (HP:0001663)1.97068094
135Papillary thyroid carcinoma (HP:0002895)1.95682751
136Abnormality of transition element cation homeostasis (HP:0011030)1.95668326
137Spinal rigidity (HP:0003306)1.95396127
138Muscular dystrophy (HP:0003560)1.94819440
139Abnormality of nucleobase metabolism (HP:0010932)1.94769777
140Absent phalangeal crease (HP:0006109)1.93174379
141Episodic fever (HP:0001954)1.93137662
142Chronic obstructive pulmonary disease (HP:0006510)1.93113306
143Obstructive lung disease (HP:0006536)1.93113306
144Abnormal urine phosphate concentration (HP:0012599)1.92853555
145Calcaneovalgus deformity (HP:0001848)1.90195525
146Spontaneous abortion (HP:0005268)1.89016517
147Abnormality of alanine metabolism (HP:0010916)1.87498045
148Hyperalaninemia (HP:0003348)1.87498045
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87498045
150Broad metatarsal (HP:0001783)1.86687162
151Nephrolithiasis (HP:0000787)1.85379907
152Abnormality of urine glucose concentration (HP:0011016)1.85053601
153Glycosuria (HP:0003076)1.85053601
154Hyperthyroidism (HP:0000836)1.83221106
155Male infertility (HP:0003251)1.80494031
156Basal ganglia calcification (HP:0002135)1.78045558
157Increased serum ferritin (HP:0003281)1.75940338
158Eczematoid dermatitis (HP:0000976)1.71694821
159Biliary tract neoplasm (HP:0100574)1.69863044
160Tongue fasciculations (HP:0001308)1.69187460
161Hypophosphatemic rickets (HP:0004912)1.69146757
162Type 2 muscle fiber atrophy (HP:0003554)1.67251860
163Abnormality of the prostate (HP:0008775)1.67031160
164Muscle fibrillation (HP:0010546)1.66796066
165Vertigo (HP:0002321)1.66532908
166Muscle fiber atrophy (HP:0100295)1.66401709
167Autoimmune hemolytic anemia (HP:0001890)1.65575791
168Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.63545965
169Dysautonomia (HP:0002459)1.61607087
170Polycythemia (HP:0001901)1.60936236
171Arthropathy (HP:0003040)1.60102936
172Chest pain (HP:0100749)1.58907591
173Uterine leiomyosarcoma (HP:0002891)1.58486577
174Leiomyosarcoma (HP:0100243)1.58486577
175Mucosal telangiectasiae (HP:0100579)1.58292686
176Transitional cell carcinoma of the bladder (HP:0006740)1.58185443
177Congenital sensorineural hearing impairment (HP:0008527)1.55100902
178Elevated erythrocyte sedimentation rate (HP:0003565)1.54121017
179Abnormal ciliary motility (HP:0012262)1.53036168
180Distal lower limb amyotrophy (HP:0008944)1.52888606
181Mitral stenosis (HP:0001718)1.52704974
182Recurrent abscess formation (HP:0002722)1.51140346
183Thrombophlebitis (HP:0004418)1.47001687
184Bladder neoplasm (HP:0009725)1.44461452
185Bladder carcinoma (HP:0002862)1.44461452
186Polyphagia (HP:0002591)1.42966075
187Recurrent bacterial skin infections (HP:0005406)1.41816932
188Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.40289717
189Weak cry (HP:0001612)1.39826818
190Leukocytosis (HP:0001974)1.39773636
191Testicular neoplasm (HP:0010788)1.37814980
192Diplopia (HP:0000651)1.36815330
193Abnormality of binocular vision (HP:0011514)1.36815330
194Pulmonary embolism (HP:0002204)1.36631286
195Cerebral ischemia (HP:0002637)1.35360898
196Infertility (HP:0000789)1.35237881
197Dysostosis multiplex (HP:0000943)1.34581781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.47309361
2RIPK45.10714747
3WNK34.47558737
4TTN3.62724776
5OXSR13.61193420
6OBSCN3.49164110
7TEC3.19364388
8EIF2AK13.06703792
9BTK2.87929308
10STK38L2.61450398
11LATS12.53249265
12TAOK32.26157778
13CSF1R2.24999699
14SYK2.23870916
15ZAK2.16854468
16WNK12.16371426
17DMPK2.12743886
18GRK52.09332081
19PDK42.02909841
20PDK32.02909841
21TRIB32.00726379
22STK391.95513953
23FGR1.93582147
24BMPR21.90710212
25ZAP701.90114692
26PIK3CA1.82504888
27PIK3CG1.82158222
28GRK61.80653799
29RIPK11.68792634
30EPHA31.59103435
31PAK31.57024865
32ADRBK21.54816919
33NEK11.53675718
34PDK21.51086399
35ACVR1B1.42796163
36HCK1.41316593
37BLK1.40739168
38EPHB21.40697318
39BCKDK1.38064736
40MYLK1.37261899
41MAPKAPK31.35984842
42PHKG21.33777953
43PHKG11.33777953
44PDGFRA1.32508130
45PLK21.31877450
46LRRK21.30025130
47FES1.28980454
48STK381.24564640
49MAP3K71.23198815
50PTK2B1.22200279
51DDR21.20449990
52PAK11.18835429
53PTK21.18259823
54LYN1.17964465
55TNK21.15550999
56FRK1.13020933
57IKBKB1.11987297
58PAK21.11518541
59LATS21.09606466
60TXK1.08792644
61ERN11.08434944
62TGFBR21.07004117
63ADRBK10.96759546
64PIM20.95628256
65FER0.94874601
66ROCK10.94188908
67IRAK10.93959536
68MAP3K50.91494913
69CSK0.90560621
70ITK0.88779204
71SGK4940.88534487
72SGK2230.88534487
73TNIK0.86729429
74DYRK1B0.85494718
75STK100.84928264
76EPHB10.83393632
77ARAF0.81905303
78MATK0.81273575
79PTK60.80862215
80MET0.80279511
81MARK30.78766756
82NEK90.76665862
83MST1R0.76079609
84STK30.74715106
85SGK30.74406939
86MUSK0.71791225
87MAP2K30.71069911
88PAK40.70560381
89BMPR1B0.69139366
90PDK10.67652128
91SIK30.67614897
92TRIM280.67131615
93PRKAA10.66719940
94ILK0.65791385
95PNCK0.63935190
96DAPK20.63537764
97JAK30.63243517
98ERBB20.63111675
99PKN10.62894338
100NUAK10.62455089
101MTOR0.61905127
102GSK3A0.61748512
103MAPK120.58180189
104TAOK20.56948968
105MAP2K10.55071847
106STK40.55034608
107LCK0.53786011
108FGFR40.52451722
109PINK10.51836894
110BMX0.51729465
111SGK20.51422307
112PRKAA20.51355108
113STK240.51250128
114PKN20.50305525
115TRPM70.49903258
116SGK10.48897067
117MAP3K120.48703411
118PRKACG0.48547436
119MAP3K30.48314254
120PRKD10.47866504
121MINK10.47340542
122MAP4K10.46488222
123FYN0.46411420
124NME10.46176173
125CDC42BPA0.45325254
126CAMK1G0.44938459
127ABL20.44376869
128CAMKK20.43154913
129TIE10.42953516
130PDGFRB0.42689540
131ROCK20.42357577
132TLK10.42280187
133JAK10.42187077
134PRKG10.41491050
135GRK10.41145488
136CDK60.40181679
137JAK20.39628719
138PRKD20.39501199
139MST40.39081700
140BCR0.38388442
141MOS0.37870250
142PDPK10.37410118
143LMTK20.36941188
144TESK20.35966262
145TAOK10.35806427
146PRKCH0.34982639
147PRKD30.34819863
148MAPK130.34812473
149RET0.34548236
150IRAK40.34321747
151PRKCQ0.33839934
152INSR0.33820836
153PRKCD0.33739863
154YES10.33649702
155NLK0.32770966
156SIK10.32593185
157LIMK10.31613881
158DAPK10.31164447
159NTRK10.30488695
160PRKCE0.30027852
161IRAK20.29684609
162PIM10.29381029
163FGFR30.29322417
164DAPK30.29095935
165MAP2K40.28759026
166IRAK30.27998601
167PRKCB0.27772907
168PRKCA0.27571116
169PRKG20.27485390
170FGFR10.27467988
171ERBB40.27148282

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.73372943
2SNARE interactions in vesicular transport_Homo sapiens_hsa041303.12423164
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.80317262
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.76117415
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.64907932
6Butanoate metabolism_Homo sapiens_hsa006502.64676792
7Propanoate metabolism_Homo sapiens_hsa006402.56378474
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.51188243
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.46591755
10Hematopoietic cell lineage_Homo sapiens_hsa046402.43406954
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.42924937
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42423701
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40962477
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33085510
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16767347
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15884355
17Dilated cardiomyopathy_Homo sapiens_hsa054142.12290564
18Arachidonic acid metabolism_Homo sapiens_hsa005902.01988783
19Chemokine signaling pathway_Homo sapiens_hsa040621.93157401
20ECM-receptor interaction_Homo sapiens_hsa045121.92787757
21Fatty acid degradation_Homo sapiens_hsa000711.90039055
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88080253
23Pyruvate metabolism_Homo sapiens_hsa006201.85143452
24Protein digestion and absorption_Homo sapiens_hsa049741.79563678
25Gap junction_Homo sapiens_hsa045401.79057564
26Serotonergic synapse_Homo sapiens_hsa047261.67381494
27Focal adhesion_Homo sapiens_hsa045101.65656109
28Peroxisome_Homo sapiens_hsa041461.61833265
29Tryptophan metabolism_Homo sapiens_hsa003801.59208820
30Vitamin digestion and absorption_Homo sapiens_hsa049771.46537262
31Lysine degradation_Homo sapiens_hsa003101.43628567
32Bile secretion_Homo sapiens_hsa049761.41777783
33Systemic lupus erythematosus_Homo sapiens_hsa053221.40913761
34Carbon metabolism_Homo sapiens_hsa012001.40501679
35B cell receptor signaling pathway_Homo sapiens_hsa046621.36200028
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35375603
37Fatty acid metabolism_Homo sapiens_hsa012121.35178310
38Alcoholism_Homo sapiens_hsa050341.32733227
39Endocytosis_Homo sapiens_hsa041441.29028383
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28629249
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28017952
42Starch and sucrose metabolism_Homo sapiens_hsa005001.21094500
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19643277
44Sulfur metabolism_Homo sapiens_hsa009201.17924867
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17139403
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.16650968
47Pancreatic secretion_Homo sapiens_hsa049721.14840595
48PPAR signaling pathway_Homo sapiens_hsa033201.14124015
49beta-Alanine metabolism_Homo sapiens_hsa004101.13412019
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12664224
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11820102
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11025752
53Amoebiasis_Homo sapiens_hsa051461.10276245
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08683210
55Phagosome_Homo sapiens_hsa041451.08407054
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08047099
57Arginine and proline metabolism_Homo sapiens_hsa003301.07790237
58Tight junction_Homo sapiens_hsa045301.07378546
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.05528849
60Nitrogen metabolism_Homo sapiens_hsa009101.04581039
61Adherens junction_Homo sapiens_hsa045201.04402740
62Cardiac muscle contraction_Homo sapiens_hsa042601.03841701
63Glutathione metabolism_Homo sapiens_hsa004801.02658501
64T cell receptor signaling pathway_Homo sapiens_hsa046601.02530500
65Proteoglycans in cancer_Homo sapiens_hsa052051.02018643
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01264595
67Osteoclast differentiation_Homo sapiens_hsa043800.99689909
68Olfactory transduction_Homo sapiens_hsa047400.98920885
69Graft-versus-host disease_Homo sapiens_hsa053320.96745948
70Morphine addiction_Homo sapiens_hsa050320.96379023
71Long-term depression_Homo sapiens_hsa047300.95290126
72Linoleic acid metabolism_Homo sapiens_hsa005910.94782832
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93404191
74Staphylococcus aureus infection_Homo sapiens_hsa051500.92275691
75Collecting duct acid secretion_Homo sapiens_hsa049660.90858421
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88758012
77Other glycan degradation_Homo sapiens_hsa005110.88013802
78Arginine biosynthesis_Homo sapiens_hsa002200.86901727
79Primary immunodeficiency_Homo sapiens_hsa053400.86140043
80Circadian entrainment_Homo sapiens_hsa047130.85161603
81Viral myocarditis_Homo sapiens_hsa054160.83457544
82Bladder cancer_Homo sapiens_hsa052190.83216269
83Insulin resistance_Homo sapiens_hsa049310.82729875
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80849877
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79680593
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77729360
87Mineral absorption_Homo sapiens_hsa049780.75590093
88Hippo signaling pathway_Homo sapiens_hsa043900.75505229
89Small cell lung cancer_Homo sapiens_hsa052220.74705821
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74237620
91Asthma_Homo sapiens_hsa053100.74036568
92Allograft rejection_Homo sapiens_hsa053300.71874268
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71853498
94Renin-angiotensin system_Homo sapiens_hsa046140.71560991
95Biosynthesis of amino acids_Homo sapiens_hsa012300.70923278
96Thyroid hormone synthesis_Homo sapiens_hsa049180.70650512
97Fatty acid elongation_Homo sapiens_hsa000620.70551847
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69778909
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68452297
100Ras signaling pathway_Homo sapiens_hsa040140.67531648
101Autoimmune thyroid disease_Homo sapiens_hsa053200.66616389
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65258149
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64684242
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64038354
105GABAergic synapse_Homo sapiens_hsa047270.63381294
106Gastric acid secretion_Homo sapiens_hsa049710.62240049
107Lysosome_Homo sapiens_hsa041420.61950798
108TGF-beta signaling pathway_Homo sapiens_hsa043500.61949826
109Calcium signaling pathway_Homo sapiens_hsa040200.61757405
110Glucagon signaling pathway_Homo sapiens_hsa049220.60926853
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.59528701
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59454453
113Rheumatoid arthritis_Homo sapiens_hsa053230.58193494
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57213245
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.56191831
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.55403934
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54822655
118Viral carcinogenesis_Homo sapiens_hsa052030.54618997
119Leishmaniasis_Homo sapiens_hsa051400.54237296
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.53374735
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52309663
122AMPK signaling pathway_Homo sapiens_hsa041520.51253335
123Cholinergic synapse_Homo sapiens_hsa047250.51130837
124Non-small cell lung cancer_Homo sapiens_hsa052230.51118923
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51028679
126Melanoma_Homo sapiens_hsa052180.49894574
127Glycerolipid metabolism_Homo sapiens_hsa005610.49656633
128Legionellosis_Homo sapiens_hsa051340.49602577
129MicroRNAs in cancer_Homo sapiens_hsa052060.48974843
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48917428
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.48769137
132Phototransduction_Homo sapiens_hsa047440.48561815
133Regulation of autophagy_Homo sapiens_hsa041400.47559172
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47055017
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46995302
136FoxO signaling pathway_Homo sapiens_hsa040680.46599545
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46479504
138Endometrial cancer_Homo sapiens_hsa052130.46092569
139Tuberculosis_Homo sapiens_hsa051520.45962142
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45928027
141Selenocompound metabolism_Homo sapiens_hsa004500.45665340
142Renin secretion_Homo sapiens_hsa049240.44324322
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.44011672
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43669605
145Mismatch repair_Homo sapiens_hsa034300.40967287
146Salmonella infection_Homo sapiens_hsa051320.40931548
147Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40777292
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.40379991
149Apoptosis_Homo sapiens_hsa042100.40139402
150Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40075461
151NF-kappa B signaling pathway_Homo sapiens_hsa040640.40068230
152Pancreatic cancer_Homo sapiens_hsa052120.39693661
153Insulin signaling pathway_Homo sapiens_hsa049100.39273412
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39235100
155Fructose and mannose metabolism_Homo sapiens_hsa000510.38957955
156Glioma_Homo sapiens_hsa052140.38510571
157Fat digestion and absorption_Homo sapiens_hsa049750.37911610
158Platelet activation_Homo sapiens_hsa046110.37256539
159Rap1 signaling pathway_Homo sapiens_hsa040150.35657468
160Primary bile acid biosynthesis_Homo sapiens_hsa001200.34994569
161Oxytocin signaling pathway_Homo sapiens_hsa049210.34329459
162Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33533824
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31710291
164Choline metabolism in cancer_Homo sapiens_hsa052310.30788462
165Chronic myeloid leukemia_Homo sapiens_hsa052200.30503954
166Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30469159
167Pentose phosphate pathway_Homo sapiens_hsa000300.30031929
168Shigellosis_Homo sapiens_hsa051310.29576425
169Malaria_Homo sapiens_hsa051440.28964997
170Prostate cancer_Homo sapiens_hsa052150.26106897

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »