MAP3K8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interleukin-12 biosynthetic process (GO:0045075)4.58168498
2negative regulation of interleukin-12 production (GO:0032695)4.57414650
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.44159946
4regulation of vitamin D biosynthetic process (GO:0060556)4.36852844
5positive regulation of gamma-delta T cell activation (GO:0046645)4.35846029
6response to muramyl dipeptide (GO:0032495)4.16036983
7neutrophil activation involved in immune response (GO:0002283)4.10819569
8response to peptidoglycan (GO:0032494)4.08874067
9positive regulation by symbiont of host defense response (GO:0052509)4.06147563
10modulation by symbiont of host defense response (GO:0052031)4.06147563
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06147563
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06147563
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.06147563
14modulation by symbiont of host immune response (GO:0052553)4.06147563
15positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.02637824
16NIK/NF-kappaB signaling (GO:0038061)3.95271958
17positive regulation of heat generation (GO:0031652)3.91518996
18myeloid dendritic cell activation (GO:0001773)3.80837455
19myeloid dendritic cell differentiation (GO:0043011)3.80075467
20regulation of fever generation (GO:0031620)3.77803478
21positive regulation of interferon-alpha production (GO:0032727)3.77027012
22positive regulation of natural killer cell differentiation (GO:0032825)3.76440182
23type I interferon signaling pathway (GO:0060337)3.69038752
24cellular response to type I interferon (GO:0071357)3.69038752
25positive regulation of interleukin-12 production (GO:0032735)3.65537544
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.65381103
27response to type I interferon (GO:0034340)3.64950450
28antigen processing and presentation of endogenous antigen (GO:0019883)3.64463893
29immunoglobulin mediated immune response (GO:0016064)3.58590462
30regulation of interferon-alpha production (GO:0032647)3.58556220
31regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.57702384
32regulation of chronic inflammatory response (GO:0002676)3.51975695
33interferon-gamma-mediated signaling pathway (GO:0060333)3.48497162
34granulocyte activation (GO:0036230)3.47970325
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.44713093
36neutrophil activation (GO:0042119)3.43806558
37regulation of vitamin metabolic process (GO:0030656)3.43715841
38positive regulation of isotype switching (GO:0045830)3.39132440
39positive regulation of chemokine biosynthetic process (GO:0045080)3.38035195
40positive regulation of antigen processing and presentation (GO:0002579)3.37781425
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37518381
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37518381
43defense response to protozoan (GO:0042832)3.31628049
44germinal center formation (GO:0002467)3.31509761
45negative regulation of cytokine production involved in immune response (GO:0002719)3.29405638
46regulation of B cell receptor signaling pathway (GO:0050855)3.28884730
47positive regulation of mast cell activation (GO:0033005)3.26708841
48positive regulation of acute inflammatory response (GO:0002675)3.22543378
49regulation of T-helper 1 cell differentiation (GO:0045625)3.21438533
50regulation of podosome assembly (GO:0071801)3.19390353
51regulation of T-helper cell differentiation (GO:0045622)3.19164885
52regulation of RIG-I signaling pathway (GO:0039535)3.18911060
53positive regulation of interleukin-17 production (GO:0032740)3.18404900
54positive regulation of mast cell degranulation (GO:0043306)3.17973502
55positive regulation of mast cell activation involved in immune response (GO:0033008)3.17973502
56macrophage activation involved in immune response (GO:0002281)3.17850484
57response to protozoan (GO:0001562)3.17297683
58lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17261692
59regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.16937853
60positive regulation of B cell mediated immunity (GO:0002714)3.16674529
61positive regulation of immunoglobulin mediated immune response (GO:0002891)3.16674529
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15593629
63detection of molecule of bacterial origin (GO:0032490)3.14725526
64positive regulation of type 2 immune response (GO:0002830)3.14002734
65regulation of T-helper 2 cell differentiation (GO:0045628)3.13773929
66interferon-gamma production (GO:0032609)3.12200131
67regulation of gamma-delta T cell activation (GO:0046643)3.12084636
68T cell migration (GO:0072678)3.10976266
69negative regulation of growth of symbiont in host (GO:0044130)3.10827760
70negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.10827760
71modulation of growth of symbiont involved in interaction with host (GO:0044144)3.10827760
72regulation of growth of symbiont in host (GO:0044126)3.10827760
73regulation of interleukin-12 production (GO:0032655)3.10477816
74positive regulation of humoral immune response (GO:0002922)3.10465364
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08487294
76regulation of T cell tolerance induction (GO:0002664)3.07959084
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07527543
78JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07149175
79regulation of mast cell degranulation (GO:0043304)3.06783064
80regulation of interleukin-8 biosynthetic process (GO:0045414)3.06723274
81detection of other organism (GO:0098543)3.05921528
82regulation of immunoglobulin secretion (GO:0051023)3.05252375
83regulation of cytokine secretion involved in immune response (GO:0002739)3.05184239
84regulation of hypersensitivity (GO:0002883)3.04886379
85leukocyte aggregation (GO:0070486)3.04816302
86positive regulation of T-helper cell differentiation (GO:0045624)3.04405060
87positive regulation of NF-kappaB import into nucleus (GO:0042346)3.04306865
88regulation of interleukin-17 production (GO:0032660)3.03784270
89regulation of mast cell activation (GO:0033003)3.03011140
90positive regulation of interleukin-10 production (GO:0032733)3.02810351
91regulation of isotype switching to IgG isotypes (GO:0048302)3.00851856
92regulation of germinal center formation (GO:0002634)2.99730361
93regulation of chemokine biosynthetic process (GO:0045073)2.98561910
94regulation of heat generation (GO:0031650)2.96834482
95cellular response to interferon-gamma (GO:0071346)2.96819221
96regulation of antigen processing and presentation (GO:0002577)2.96661613
97regulation of inflammatory response to antigenic stimulus (GO:0002861)2.96142920
98regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.95997408
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95855380
100regulation of gamma-delta T cell differentiation (GO:0045586)2.95649178
101regulation of interferon-beta biosynthetic process (GO:0045357)2.95583031
102regulation of alpha-beta T cell proliferation (GO:0046640)2.95325696
103myeloid cell activation involved in immune response (GO:0002275)2.95137017
104positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.94675907
105regulation of response to interferon-gamma (GO:0060330)2.93757100
106positive regulation of DNA recombination (GO:0045911)2.93121653
107response to interleukin-15 (GO:0070672)2.92766431
108positive regulation of interleukin-2 production (GO:0032743)2.89513972
109natural killer cell mediated immunity (GO:0002228)2.88569775
110natural killer cell mediated cytotoxicity (GO:0042267)2.88569775
111negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87701335
112negative regulation of cell killing (GO:0031342)2.87701335
113negative thymic T cell selection (GO:0045060)2.87372891
114dendritic cell differentiation (GO:0097028)2.87060479
115detection of bacterium (GO:0016045)2.86739833
116positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.84840420
117negative regulation of T cell mediated immunity (GO:0002710)2.84585753
118negative regulation of interleukin-17 production (GO:0032700)2.84425232
119macrophage activation (GO:0042116)2.84281960
120mature B cell differentiation involved in immune response (GO:0002313)2.83719558
121positive regulation of cytokine biosynthetic process (GO:0042108)2.82908471
122cellular extravasation (GO:0045123)2.82741458
123regulation of mast cell activation involved in immune response (GO:0033006)2.82407388
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80054325
125response to host immune response (GO:0052572)2.80054325
126negative T cell selection (GO:0043383)2.79871076
127cytokine secretion (GO:0050663)2.79529424
128T cell activation involved in immune response (GO:0002286)2.78458519
129T-helper 1 type immune response (GO:0042088)2.78011503
130dendritic cell chemotaxis (GO:0002407)2.77950050
131cellular response to zinc ion (GO:0071294)2.77276097
132positive regulation of interferon-beta production (GO:0032728)2.76465241
133microglial cell activation (GO:0001774)2.76376359
134positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.76055866
135natural killer cell activation (GO:0030101)2.75863795
136respiratory burst (GO:0045730)2.75784740
137regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.75645753
138positive regulation of B cell differentiation (GO:0045579)2.75429412
139positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73239713
140negative regulation of lipid storage (GO:0010888)2.73147690
141positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73135791
142myeloid leukocyte activation (GO:0002274)2.73114072
143regulation of natural killer cell differentiation (GO:0032823)2.72241393
144regulation of B cell differentiation (GO:0045577)2.69528198
145response to interferon-alpha (GO:0035455)2.69513739
146B cell mediated immunity (GO:0019724)2.69220336
147positive thymic T cell selection (GO:0045059)2.69090505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.18297611
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.83409737
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.54890814
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.09206771
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.49616037
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.25364626
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.17770207
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.77196794
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.48244381
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.44076980
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38447854
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13223907
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.05416374
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98123677
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.89930777
16* EGR1_19374776_ChIP-ChIP_THP-1_Human2.76179838
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.67220449
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64725000
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63188522
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.59260066
21* RUNX_20019798_ChIP-Seq_JUKART_Human2.58107368
22* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51091444
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.50606504
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17848708
25* MYB_26560356_Chip-Seq_TH2_Human2.12556955
26* MAF_26560356_Chip-Seq_TH1_Human1.94278362
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89080357
28SCL_19346495_ChIP-Seq_HPC-7_Human1.88533991
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78687265
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78032054
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76727062
32MYB_26560356_Chip-Seq_TH1_Human1.75102512
33* SPI1_23547873_ChIP-Seq_NB4_Human1.68531908
34* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58677529
35PU_27001747_Chip-Seq_BMDM_Mouse1.58173723
36VDR_24787735_ChIP-Seq_THP-1_Human1.57908720
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56065121
38* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48852881
39* RUNX1_22412390_ChIP-Seq_EML_Mouse1.47776959
40VDR_24763502_ChIP-Seq_THP-1_Human1.47519994
41GATA1_22025678_ChIP-Seq_K562_Human1.46147055
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45314234
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40445221
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.40071635
45MYC_22102868_ChIP-Seq_BL_Human1.38584607
46* SPI1_23127762_ChIP-Seq_K562_Human1.36981323
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28519544
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28030770
49* GATA3_27048872_Chip-Seq_THYMUS_Human1.27742510
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25876685
51* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21837234
52* GATA3_26560356_Chip-Seq_TH2_Human1.16544614
53TCF7_22412390_ChIP-Seq_EML_Mouse1.16532869
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.15287967
55GATA1_19941826_ChIP-Seq_K562_Human1.13945437
56* UTX_26944678_Chip-Seq_JUKART_Human1.12480178
57* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12034331
58* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12034331
59EGR1_19032775_ChIP-ChIP_M12_Human1.11056218
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09676186
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.09512250
62VDR_21846776_ChIP-Seq_THP-1_Human1.08158966
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07761975
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06853488
65* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06847540
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05608860
67* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04152434
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01263254
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00932305
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96425225
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96012966
72* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95893057
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95283813
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94730006
75* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94640592
76STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94346713
77WT1_19549856_ChIP-ChIP_CCG9911_Human0.93102351
78MAF_26560356_Chip-Seq_TH2_Human0.92313702
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92095569
80STAT1_20625510_ChIP-Seq_HELA_Human0.91903492
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91135490
82* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89056788
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88101091
84* CJUN_26792858_Chip-Seq_BT549_Human0.87135376
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85752506
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83521061
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82940838
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82882596
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82872922
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82124595
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.81539405
92P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81278232
93* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81028085
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80826536
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79037527
96* SMRT_27268052_Chip-Seq_Bcells_Human0.77365070
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77210568
98* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76978047
99KDM2B_26808549_Chip-Seq_DND41_Human0.76972901
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75770264
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.75640773
102* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75542634
103* SOX2_20726797_ChIP-Seq_SW620_Human0.73902161
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73317780
105* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73248048
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71713865
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.71327142
108* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71084371
109TFEB_21752829_ChIP-Seq_HELA_Human0.69691605
110BCL6_27268052_Chip-Seq_Bcells_Human0.69367487
111* GATA2_19941826_ChIP-Seq_K562_Human0.69136589
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68148529
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.67956652
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.67644103
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67560993
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65527599
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63979259
118* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63380063
119* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63338514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.50532548
2MP0000685_abnormal_immune_system3.70550452
3MP0009785_altered_susceptibility_to3.45598218
4MP0002148_abnormal_hypersensitivity_rea3.37805795
5MP0003436_decreased_susceptibility_to3.36623862
6MP0005671_abnormal_response_to3.26992397
7MP0005387_immune_system_phenotype3.23059831
8MP0001790_abnormal_immune_system3.23059831
9MP0005000_abnormal_immune_tolerance3.18865956
10* MP0001800_abnormal_humoral_immune3.06734589
11MP0003724_increased_susceptibility_to3.06217028
12MP0006082_CNS_inflammation2.79771236
13* MP0002452_abnormal_antigen_presenting2.79456562
14MP0004510_myositis2.77258227
15MP0002419_abnormal_innate_immunity2.75129101
16* MP0005025_abnormal_response_to2.71108036
17* MP0002723_abnormal_immune_serum2.68303835
18* MP0001819_abnormal_immune_cell2.39848696
19* MP0002420_abnormal_adaptive_immunity2.38778560
20MP0004947_skin_inflammation2.37523745
21MP0003303_peritoneal_inflammation2.23108865
22MP0002405_respiratory_system_inflammati2.17468927
23MP0001853_heart_inflammation2.08514025
24MP0002006_tumorigenesis2.03650750
25MP0002166_altered_tumor_susceptibility1.93058076
26MP0008004_abnormal_stomach_pH1.87369911
27MP0003763_abnormal_thymus_physiology1.86608327
28MP0001533_abnormal_skeleton_physiology1.84407744
29* MP0010155_abnormal_intestine_physiology1.82527259
30* MP0002398_abnormal_bone_marrow1.80102292
31* MP0000716_abnormal_immune_system1.78968969
32* MP0001845_abnormal_inflammatory_respons1.78939342
33MP0002254_reproductive_system_inflammat1.75580275
34MP0005464_abnormal_platelet_physiology1.74210449
35MP0003300_gastrointestinal_ulcer1.67242396
36MP0001851_eye_inflammation1.62157196
37MP0009764_decreased_sensitivity_to1.60284516
38MP0003448_altered_tumor_morphology1.60251674
39MP0001873_stomach_inflammation1.58768576
40MP0005310_abnormal_salivary_gland1.58042829
41MP0009333_abnormal_splenocyte_physiolog1.56216140
42MP0008469_abnormal_protein_level1.44512275
43MP0005167_abnormal_blood-brain_barrier1.44274208
44* MP0002429_abnormal_blood_cell1.42242932
45MP0005076_abnormal_cell_differentiation1.41293042
46MP0004381_abnormal_hair_follicle1.40534911
47MP0000689_abnormal_spleen_morphology1.40440699
48MP0000858_altered_metastatic_potential1.40299153
49MP0005451_abnormal_body_composition1.38768107
50MP0002722_abnormal_immune_system1.35990069
51MP0002332_abnormal_exercise_endurance1.30940571
52MP0003453_abnormal_keratinocyte_physiol1.27693761
53MP0009278_abnormal_bone_marrow1.25771067
54MP0002998_abnormal_bone_remodeling1.23511163
55MP0002138_abnormal_hepatobiliary_system1.23288744
56MP0003656_abnormal_erythrocyte_physiolo1.21226860
57MP0005058_abnormal_lysosome_morphology1.14050710
58MP0002009_preneoplasia1.13994152
59MP0002396_abnormal_hematopoietic_system1.12193150
60MP0002139_abnormal_hepatobiliary_system1.10418632
61MP0003195_calcinosis1.09232422
62MP0003566_abnormal_cell_adhesion1.08867913
63MP0009840_abnormal_foam_cell1.07870368
64MP0004808_abnormal_hematopoietic_stem1.07374080
65MP0010352_gastrointestinal_tract_polyps1.07096982
66MP0002877_abnormal_melanocyte_morpholog1.06568308
67MP0000703_abnormal_thymus_morphology1.05082264
68MP0002277_abnormal_respiratory_mucosa1.01858249
69MP0003183_abnormal_peptide_metabolism1.01421507
70MP0000343_altered_response_to1.00475625
71MP0002933_joint_inflammation0.99919276
72MP0005390_skeleton_phenotype0.99255253
73MP0006054_spinal_hemorrhage0.98917215
74MP0001545_abnormal_hematopoietic_system0.98481243
75MP0005397_hematopoietic_system_phenotyp0.98481243
76MP0000569_abnormal_digit_pigmentation0.97328463
77MP0005164_abnormal_response_to0.96169734
78MP0003045_fibrosis0.95878851
79MP0003191_abnormal_cellular_cholesterol0.94233496
80MP0003828_pulmonary_edema0.93266908
81MP0003806_abnormal_nucleotide_metabolis0.90371409
82MP0002132_abnormal_respiratory_system0.90144934
83MP0003075_altered_response_to0.87893190
84MP0003646_muscle_fatigue0.87586199
85MP0001216_abnormal_epidermal_layer0.85435161
86MP0003866_abnormal_defecation0.85312967
87MP0005166_decreased_susceptibility_to0.85273841
88MP0001663_abnormal_digestive_system0.83808915
89MP0004782_abnormal_surfactant_physiolog0.82343255
90MP0005174_abnormal_tail_pigmentation0.80933852
91MP0003172_abnormal_lysosome_physiology0.80381033
92MP0000627_abnormal_mammary_gland0.76878557
93MP0010307_abnormal_tumor_latency0.76729291
94MP0005275_abnormal_skin_tensile0.76675587
95MP0002060_abnormal_skin_morphology0.76395672
96MP0009763_increased_sensitivity_to0.76177943
97MP0005165_increased_susceptibility_to0.75735523
98MP0000249_abnormal_blood_vessel0.75140298
99MP0000767_abnormal_smooth_muscle0.75019687
100MP0009765_abnormal_xenobiotic_induced0.73825219
101MP0001881_abnormal_mammary_gland0.73268857
102MP0003091_abnormal_cell_migration0.73106805
103MP0005023_abnormal_wound_healing0.72541749
104MP0002163_abnormal_gland_morphology0.72183495
105MP0001501_abnormal_sleep_pattern0.71723957
106MP0005535_abnormal_body_temperature0.71586400
107MP0003690_abnormal_glial_cell0.71082993
108MP0004883_abnormal_blood_vessel0.71060888
109MP0000371_diluted_coat_color0.70893897
110MP0000465_gastrointestinal_hemorrhage0.70150888
111MP0000604_amyloidosis0.69284297
112MP0001191_abnormal_skin_condition0.68144332
113MP0003186_abnormal_redox_activity0.67769009
114MP0005647_abnormal_sex_gland0.66597720
115MP0001542_abnormal_bone_strength0.66106060
116MP0001879_abnormal_lymphatic_vessel0.65536568
117MP0002796_impaired_skin_barrier0.65144582
118MP0003795_abnormal_bone_structure0.63463382
119MP0002136_abnormal_kidney_physiology0.62942076
120MP0005666_abnormal_adipose_tissue0.54091644
121MP0000609_abnormal_liver_physiology0.51913470
122MP0005319_abnormal_enzyme/_coenzyme0.49514039
123MP0008874_decreased_physiological_sensi0.48012975
124MP0008873_increased_physiological_sensi0.45930110

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.26338822
2Recurrent abscess formation (HP:0002722)5.71907562
3Myositis (HP:0100614)5.55183114
4Recurrent bacterial skin infections (HP:0005406)5.51449683
5Optic neuritis (HP:0100653)5.44774298
6Retrobulbar optic neuritis (HP:0100654)5.44774298
7Orchitis (HP:0100796)5.41546591
8Elevated erythrocyte sedimentation rate (HP:0003565)4.77388061
9Mediastinal lymphadenopathy (HP:0100721)4.62489777
10Abnormality of glycolipid metabolism (HP:0010969)4.24838857
11Abnormality of liposaccharide metabolism (HP:0010968)4.24838857
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.24838857
13Recurrent gram-negative bacterial infections (HP:0005420)3.95833219
14Increased IgM level (HP:0003496)3.92028817
15Stomatitis (HP:0010280)3.91285117
16Recurrent fungal infections (HP:0002841)3.90739346
17Vasculitis (HP:0002633)3.80949636
18Pulmonary infiltrates (HP:0002113)3.66101420
19Abnormality of macrophages (HP:0004311)3.63612127
20Recurrent skin infections (HP:0001581)3.56267756
21Recurrent viral infections (HP:0004429)3.46315831
22Keratoconjunctivitis sicca (HP:0001097)3.39053450
23Arterial thrombosis (HP:0004420)3.31148913
24Gingivitis (HP:0000230)3.22949897
25Keratoconjunctivitis (HP:0001096)3.20454436
26Autoimmune thrombocytopenia (HP:0001973)3.16618465
27Dysostosis multiplex (HP:0000943)3.13980683
28Cellulitis (HP:0100658)3.10847988
29Meningitis (HP:0001287)3.09348495
30Systemic lupus erythematosus (HP:0002725)3.07831159
31Thick nail (HP:0001805)3.05795308
32Obstructive lung disease (HP:0006536)2.98348751
33Chronic obstructive pulmonary disease (HP:0006510)2.98348751
34Autoimmune hemolytic anemia (HP:0001890)2.97304547
35Gastrointestinal infarctions (HP:0005244)2.91635988
36Periodontitis (HP:0000704)2.88900080
37Chronic mucocutaneous candidiasis (HP:0002728)2.85936706
38Recurrent cutaneous fungal infections (HP:0011370)2.85936706
39Nasal polyposis (HP:0100582)2.84266916
40Abnormality of T cell number (HP:0011839)2.83837469
41Agammaglobulinemia (HP:0004432)2.81149998
42Chronic otitis media (HP:0000389)2.79653888
43Hypergammaglobulinemia (HP:0010702)2.78104609
44Pustule (HP:0200039)2.78084939
45Loss of speech (HP:0002371)2.78017048
46Increased IgE level (HP:0003212)2.72064706
47Polyneuropathy (HP:0001271)2.70698982
48Hemoptysis (HP:0002105)2.67913435
49Disinhibition (HP:0000734)2.66730349
50Recurrent bronchitis (HP:0002837)2.63312150
51Amyloidosis (HP:0011034)2.62118815
52Colitis (HP:0002583)2.62022306
53Leukocytosis (HP:0001974)2.61461445
54Abnormality of B cell number (HP:0010975)2.60836196
55Gangrene (HP:0100758)2.60747199
56Inflammation of the large intestine (HP:0002037)2.60647976
57IgA deficiency (HP:0002720)2.59821037
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.59301327
59T lymphocytopenia (HP:0005403)2.58575088
60Interstitial pulmonary disease (HP:0006530)2.58173382
61Abnormality of the nasal mucosa (HP:0000433)2.57864894
62Basal ganglia calcification (HP:0002135)2.56574156
63Chronic diarrhea (HP:0002028)2.55910109
64Increased serum ferritin (HP:0003281)2.54081057
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.52944648
66Prostate neoplasm (HP:0100787)2.52279948
67Eosinophilia (HP:0001880)2.50235449
68Increased cerebral lipofuscin (HP:0011813)2.47175529
69Encephalitis (HP:0002383)2.43297562
70Episodic fever (HP:0001954)2.43231814
71Vertigo (HP:0002321)2.42548372
72Osteomyelitis (HP:0002754)2.41770701
73B lymphocytopenia (HP:0010976)2.41407724
74Abnormality of T cells (HP:0002843)2.39656922
75Gastrointestinal inflammation (HP:0004386)2.37639501
76Gingival bleeding (HP:0000225)2.36509899
77Petechiae (HP:0000967)2.36266556
78Recurrent pneumonia (HP:0006532)2.35612150
79Osteolytic defects of the hand bones (HP:0009699)2.34521572
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.34521572
81Gastrointestinal stroma tumor (HP:0100723)2.30056068
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29727174
83Abnormality of polysaccharide metabolism (HP:0011012)2.29727174
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29727174
85Porencephaly (HP:0002132)2.29429801
86Prolonged bleeding time (HP:0003010)2.29140622
87Myocardial infarction (HP:0001658)2.28946269
88Urticaria (HP:0001025)2.25230953
89Keratitis (HP:0000491)2.23947110
90Anorexia (HP:0002039)2.23259309
91Purpura (HP:0000979)2.21607738
92Vacuolated lymphocytes (HP:0001922)2.21405690
93Premature loss of primary teeth (HP:0006323)2.20284194
94Hematochezia (HP:0002573)2.20272659
95Joint swelling (HP:0001386)2.19512867
96Abnormality of the pericardium (HP:0001697)2.18832722
97Urinary glycosaminoglycan excretion (HP:0003541)2.18787798
98Mucopolysacchariduria (HP:0008155)2.18787798
99Spontaneous hematomas (HP:0007420)2.18358365
100Amaurosis fugax (HP:0100576)2.18218564
101Abnormality of the pleura (HP:0002103)2.17951619
102Restrictive lung disease (HP:0002091)2.16579629
103Abnormality of iron homeostasis (HP:0011031)2.15962460
104Panhypogammaglobulinemia (HP:0003139)2.15332082
105Abnormality of T cell physiology (HP:0011840)2.15228367
106Persistence of primary teeth (HP:0006335)2.13245774
107Abnormality of eosinophils (HP:0001879)2.12419546
108IgM deficiency (HP:0002850)2.12187275
109Thrombocytosis (HP:0001894)2.12063881
110Granulocytopenia (HP:0001913)2.10177464
111IgG deficiency (HP:0004315)2.08682831
112Recurrent lower respiratory tract infections (HP:0002783)2.07030772
113Skin ulcer (HP:0200042)1.99833275
114Pulmonary embolism (HP:0002204)1.98009501
115Glomerulopathy (HP:0100820)1.96966096
116Emphysema (HP:0002097)1.94736963
117Sepsis (HP:0100806)1.94002612
118Peritonitis (HP:0002586)1.93582635
119Epistaxis (HP:0000421)1.93468802
120Abnormality of the prostate (HP:0008775)1.92739527
121Abnormality of cells of the lymphoid lineage (HP:0012140)1.92002030
122Arthralgia (HP:0002829)1.91586058
123Chest pain (HP:0100749)1.90882990
124Lymphopenia (HP:0001888)1.90239437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.94297754
2MAP4K13.13216443
3TBK13.12889873
4TYK23.06738072
5TXK3.02210054
6IKBKE3.00694657
7IRAK42.90201197
8* IKBKB2.78948650
9JAK32.74291299
10RIPK42.42732826
11BLK2.39522175
12IRAK32.34333246
13JAK12.17017338
14CHUK2.06376913
15EPHA31.98010500
16TAOK21.95713832
17ITK1.87505835
18MAP3K131.86245941
19EPHB11.83629439
20PIM21.77398199
21TGFBR21.76687852
22PRPF4B1.75556084
23STK101.71025248
24ZAP701.68714548
25FGFR41.65860304
26IRAK11.63267779
27KIT1.51290433
28FGFR31.50986632
29ERN11.48783260
30TLK11.44754335
31MST41.44370759
32DMPK1.43264356
33NME21.40945207
34TEC1.40124207
35CSK1.36525120
36HCK1.33548442
37PIM11.32957863
38BTK1.31802228
39SYK1.29718506
40TAOK11.25724445
41DDR21.20709851
42MAP3K111.15386220
43NLK1.13922039
44CSF1R1.11140533
45MAP3K31.08315724
46JAK21.07221244
47LCK1.06153529
48NEK91.02907747
49STK241.01232371
50ADRBK20.99148588
51GSK3A0.96199372
52GRK70.94917162
53MARK30.93807576
54EIF2AK20.91125809
55TNK20.91105252
56IRAK20.90077206
57MAPK150.89172623
58RPS6KA40.84644573
59CDC42BPA0.82837211
60LYN0.82719270
61MAP3K50.78781890
62MAP2K30.74897664
63LRRK20.74547349
64BMX0.72403070
65PTK60.71619867
66SIK30.71209793
67TAOK30.68077987
68NUAK10.65576627
69STK40.64341418
70RIPK10.63428733
71PRKCQ0.62476136
72CDK90.62396474
73MAPKAPK20.61657878
74MAP3K120.61449902
75TESK20.60630780
76HIPK20.58659741
77TRPM70.57881695
78STK30.57611798
79FES0.57085354
80MST1R0.56773257
81BMPR1B0.56514430
82PDK10.52589787
83MAP2K60.51516482
84PBK0.51297170
85CDK60.50447349
86ABL10.48523190
87CLK10.47900890
88ABL20.46328709
89PRKCD0.45589363
90EIF2AK30.45336654
91MAPK40.44812507
92MAP3K100.43662625
93FLT30.41792870
94GRK60.41169935
95PDPK10.41088173
96PDGFRB0.40945286
97PKN10.40553069
98EGFR0.40159254
99TGFBR10.38092499
100RPS6KA50.37382440
101CDK120.36897276
102NEK60.36584793
103MAPK120.36497243
104KDR0.35623416
105IGF1R0.35572902
106FGR0.35245073
107MATK0.35122688
108YES10.34845610
109MOS0.32828803
110FYN0.32808167
111MAP3K10.32529227
112ARAF0.31685169
113PIK3CA0.31336110
114RPS6KA10.30606508
115MAPK30.29882174
116ERBB30.29829424
117CDK190.28831957
118SIK20.28794250
119RPS6KA60.27400338
120SGK30.26961874
121DAPK30.26820393
122MAPK110.26687640
123CDK40.26633212
124MAPK70.26332358
125RPS6KL10.25181750
126RPS6KC10.25181750
127INSR0.24473847
128MAP2K20.23427252
129PIK3CG0.23197199
130PDK20.22876064
131* BMPR20.21848280

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.88412437
2Allograft rejection_Homo sapiens_hsa053303.46715926
3NF-kappa B signaling pathway_Homo sapiens_hsa040643.02201870
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.97032473
5Leishmaniasis_Homo sapiens_hsa051402.91389953
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.49770125
7Osteoclast differentiation_Homo sapiens_hsa043802.46492470
8* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42718523
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.33189081
10Measles_Homo sapiens_hsa051622.31661490
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.17739161
12Type I diabetes mellitus_Homo sapiens_hsa049402.13584320
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11190476
14Malaria_Homo sapiens_hsa051442.06387200
15Staphylococcus aureus infection_Homo sapiens_hsa051502.02358082
16Primary immunodeficiency_Homo sapiens_hsa053402.02139574
17Legionellosis_Homo sapiens_hsa051342.00755142
18* TNF signaling pathway_Homo sapiens_hsa046681.99571210
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.90285485
20Asthma_Homo sapiens_hsa053101.85619475
21Autoimmune thyroid disease_Homo sapiens_hsa053201.84362516
22Pertussis_Homo sapiens_hsa051331.82663755
23Toxoplasmosis_Homo sapiens_hsa051451.78772231
24Rheumatoid arthritis_Homo sapiens_hsa053231.77379280
25B cell receptor signaling pathway_Homo sapiens_hsa046621.76880583
26African trypanosomiasis_Homo sapiens_hsa051431.74734799
27Antigen processing and presentation_Homo sapiens_hsa046121.74532708
28Influenza A_Homo sapiens_hsa051641.72475185
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71386776
30Herpes simplex infection_Homo sapiens_hsa051681.61912587
31Tuberculosis_Homo sapiens_hsa051521.60256604
32Apoptosis_Homo sapiens_hsa042101.55717147
33Hematopoietic cell lineage_Homo sapiens_hsa046401.53311571
34* T cell receptor signaling pathway_Homo sapiens_hsa046601.52904152
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49366229
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45636968
37Chemokine signaling pathway_Homo sapiens_hsa040621.37814662
38Viral myocarditis_Homo sapiens_hsa054161.30267510
39Salmonella infection_Homo sapiens_hsa051321.27514859
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19984663
41Hepatitis B_Homo sapiens_hsa051611.18115696
42Shigellosis_Homo sapiens_hsa051311.07393197
43Acute myeloid leukemia_Homo sapiens_hsa052211.02435994
44Hepatitis C_Homo sapiens_hsa051601.01530777
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.96926024
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95402953
47Amoebiasis_Homo sapiens_hsa051460.92402517
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.90521922
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88809961
50Pancreatic cancer_Homo sapiens_hsa052120.87397926
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86286772
52Lysosome_Homo sapiens_hsa041420.81879869
53Prolactin signaling pathway_Homo sapiens_hsa049170.79975595
54Chronic myeloid leukemia_Homo sapiens_hsa052200.77347798
55Systemic lupus erythematosus_Homo sapiens_hsa053220.76928849
56Small cell lung cancer_Homo sapiens_hsa052220.74001996
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.71434566
58Platelet activation_Homo sapiens_hsa046110.69601699
59Phagosome_Homo sapiens_hsa041450.69380701
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66456016
61Epstein-Barr virus infection_Homo sapiens_hsa051690.62850678
62HTLV-I infection_Homo sapiens_hsa051660.59838163
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.59082512
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58880240
65Viral carcinogenesis_Homo sapiens_hsa052030.57386321
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56113683
67Other glycan degradation_Homo sapiens_hsa005110.51841477
68Notch signaling pathway_Homo sapiens_hsa043300.45412023
69p53 signaling pathway_Homo sapiens_hsa041150.41685879
70MicroRNAs in cancer_Homo sapiens_hsa052060.41544716
71Proteoglycans in cancer_Homo sapiens_hsa052050.38741308
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38526867
73Bladder cancer_Homo sapiens_hsa052190.38513491
74Insulin resistance_Homo sapiens_hsa049310.38295883
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37847469
76HIF-1 signaling pathway_Homo sapiens_hsa040660.36233089
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35890983
78FoxO signaling pathway_Homo sapiens_hsa040680.33503949
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32694882
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.32471277
81Complement and coagulation cascades_Homo sapiens_hsa046100.32195167
82Prion diseases_Homo sapiens_hsa050200.31567335
83VEGF signaling pathway_Homo sapiens_hsa043700.30424882
84* MAPK signaling pathway_Homo sapiens_hsa040100.28157830
85Collecting duct acid secretion_Homo sapiens_hsa049660.26067536
86Sphingolipid metabolism_Homo sapiens_hsa006000.25398411
87Prostate cancer_Homo sapiens_hsa052150.24633178
88TGF-beta signaling pathway_Homo sapiens_hsa043500.23710257
89Type II diabetes mellitus_Homo sapiens_hsa049300.23668809
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21176186
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21071577
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20724894
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19806426
94Adherens junction_Homo sapiens_hsa045200.19549622
95Pathways in cancer_Homo sapiens_hsa052000.18726066
96Caffeine metabolism_Homo sapiens_hsa002320.18435413
97Focal adhesion_Homo sapiens_hsa045100.17574490
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17388626
99Endocytosis_Homo sapiens_hsa041440.16658145
100Inositol phosphate metabolism_Homo sapiens_hsa005620.16278358
101Non-small cell lung cancer_Homo sapiens_hsa052230.14719401
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14138327
103Dorso-ventral axis formation_Homo sapiens_hsa043200.14000515
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12461124
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12119210
106Arachidonic acid metabolism_Homo sapiens_hsa005900.10426740
107Renal cell carcinoma_Homo sapiens_hsa052110.09559284
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08954240
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.07941433
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.07641607
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05278240
112mTOR signaling pathway_Homo sapiens_hsa041500.01734332
113PPAR signaling pathway_Homo sapiens_hsa033200.00035614
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0168608
115Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0005822

Most similar genes based on co-expression Upload to Enrichr

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