MAP3K9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.28628374
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.26543115
3locomotory exploration behavior (GO:0035641)5.83537944
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.63090005
5vocalization behavior (GO:0071625)5.45495838
6layer formation in cerebral cortex (GO:0021819)5.41989047
7glutamate secretion (GO:0014047)5.34746210
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.29368706
9synaptic vesicle exocytosis (GO:0016079)5.23440276
10regulation of synaptic vesicle exocytosis (GO:2000300)5.16195906
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11200580
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.93206237
13regulation of glutamate receptor signaling pathway (GO:1900449)4.67340183
14proline transport (GO:0015824)4.65258773
15protein localization to synapse (GO:0035418)4.65038118
16exploration behavior (GO:0035640)4.56154840
17neuron cell-cell adhesion (GO:0007158)4.55085015
18dendritic spine morphogenesis (GO:0060997)4.47876109
19regulation of synaptic vesicle transport (GO:1902803)4.47476194
20neurotransmitter secretion (GO:0007269)4.36794733
21cell migration in hindbrain (GO:0021535)4.17507864
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.11733528
23regulation of neuronal synaptic plasticity (GO:0048168)4.03084130
24regulation of synapse structural plasticity (GO:0051823)4.01498952
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99794172
26cerebellar Purkinje cell differentiation (GO:0021702)3.90711980
27gamma-aminobutyric acid transport (GO:0015812)3.85302461
28positive regulation of synapse maturation (GO:0090129)3.82938218
29dendrite morphogenesis (GO:0048813)3.82890476
30sodium ion export (GO:0071436)3.76917114
31neuronal action potential propagation (GO:0019227)3.75106672
32synaptic transmission, glutamatergic (GO:0035249)3.71870146
33cellular potassium ion homeostasis (GO:0030007)3.69170493
34neuron recognition (GO:0008038)3.68078475
35neuromuscular process controlling balance (GO:0050885)3.65353971
36axonal fasciculation (GO:0007413)3.59639449
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59220354
38glutamate receptor signaling pathway (GO:0007215)3.59158790
39activation of protein kinase A activity (GO:0034199)3.53951055
40synaptic vesicle endocytosis (GO:0048488)3.49362488
41negative regulation of microtubule polymerization (GO:0031115)3.45850505
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44413555
43neurotransmitter transport (GO:0006836)3.41753638
44positive regulation of membrane potential (GO:0045838)3.41517608
45neurotransmitter-gated ion channel clustering (GO:0072578)3.40303399
46presynaptic membrane organization (GO:0097090)3.39353334
47long-term memory (GO:0007616)3.39231972
48neuron-neuron synaptic transmission (GO:0007270)3.38661693
49pyrimidine nucleobase catabolic process (GO:0006208)3.37509932
50postsynaptic membrane organization (GO:0001941)3.35728183
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.35310933
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32950444
53regulation of neurotransmitter secretion (GO:0046928)3.30119973
54presynaptic membrane assembly (GO:0097105)3.29828506
55central nervous system projection neuron axonogenesis (GO:0021952)3.28796660
56regulation of dendritic spine morphogenesis (GO:0061001)3.25328677
57regulation of postsynaptic membrane potential (GO:0060078)3.24576285
58glycine transport (GO:0015816)3.24096270
59vesicle transport along microtubule (GO:0047496)3.22877187
60regulation of ARF protein signal transduction (GO:0032012)3.22721122
61neuronal ion channel clustering (GO:0045161)3.20628011
62axon cargo transport (GO:0008088)3.20209999
63organelle transport along microtubule (GO:0072384)3.17733735
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17531181
65regulation of synaptic plasticity (GO:0048167)3.17241724
66response to auditory stimulus (GO:0010996)3.17094779
67auditory behavior (GO:0031223)3.14275736
68cell communication by electrical coupling (GO:0010644)3.13815284
69regulation of neurotransmitter levels (GO:0001505)3.10932454
70membrane depolarization during action potential (GO:0086010)3.09738720
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09339605
72positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08718290
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08572247
74innervation (GO:0060384)3.07772572
75regulation of calcium ion-dependent exocytosis (GO:0017158)3.06961502
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06536503
77transmission of nerve impulse (GO:0019226)3.06019230
78regulation of clathrin-mediated endocytosis (GO:2000369)3.04865818
79regulation of vesicle fusion (GO:0031338)3.04811602
80neuromuscular process controlling posture (GO:0050884)3.03718130
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03282616
82establishment of nucleus localization (GO:0040023)3.02075499
83G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01783074
84clathrin coat assembly (GO:0048268)3.01453603
85synapse assembly (GO:0007416)3.01355448
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.99847664
87nucleobase catabolic process (GO:0046113)2.96943174
88apical protein localization (GO:0045176)2.96338628
89neuromuscular process (GO:0050905)2.95677632
90dendritic spine organization (GO:0097061)2.94577431
91social behavior (GO:0035176)2.94400678
92intraspecies interaction between organisms (GO:0051703)2.94400678
93response to pheromone (GO:0019236)2.94356758
94regulation of neurotransmitter transport (GO:0051588)2.93786969
95mitochondrion transport along microtubule (GO:0047497)2.93598197
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93598197
97regulation of heart rate by cardiac conduction (GO:0086091)2.93261121
98regulation of synapse maturation (GO:0090128)2.92118846
99negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91510335
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.89912047
101membrane depolarization (GO:0051899)2.88999159
102cerebellar granule cell differentiation (GO:0021707)2.88377254
103prepulse inhibition (GO:0060134)2.87616655
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87152932
105neuromuscular synaptic transmission (GO:0007274)2.86952245
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86240650
107negative regulation of dendrite morphogenesis (GO:0050774)2.85623057
108serotonin metabolic process (GO:0042428)2.83465837
109chemosensory behavior (GO:0007635)2.83292729
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81683439
111synapse organization (GO:0050808)2.81254509
112membrane hyperpolarization (GO:0060081)2.79760467
113gamma-aminobutyric acid signaling pathway (GO:0007214)2.79669661
114keratinization (GO:0031424)2.79564322
115cell communication involved in cardiac conduction (GO:0086065)2.75343655
116behavioral response to nicotine (GO:0035095)2.72173783
117positive regulation of dendritic spine development (GO:0060999)2.70021472
118potassium ion homeostasis (GO:0055075)2.64474871
119establishment of mitochondrion localization (GO:0051654)2.64455551
120cardiac conduction (GO:0061337)2.60516174
121multicellular organismal signaling (GO:0035637)2.59836352
122startle response (GO:0001964)2.59417264
123cell differentiation in hindbrain (GO:0021533)2.56541329
124primary amino compound metabolic process (GO:1901160)2.55796337
125cochlea development (GO:0090102)2.54608690
126positive regulation of synapse assembly (GO:0051965)2.54294466
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.50000900
128ephrin receptor signaling pathway (GO:0048013)2.48092319
129calcium ion-dependent exocytosis (GO:0017156)2.46679064
130mechanosensory behavior (GO:0007638)2.42222804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60138246
2* REST_21632747_ChIP-Seq_MESCs_Mouse2.84291728
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75956288
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74432430
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.72638205
6DROSHA_22980978_ChIP-Seq_HELA_Human2.69044866
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.62710655
8GBX2_23144817_ChIP-Seq_PC3_Human2.60360565
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58300754
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52059020
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46687794
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46687794
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40602001
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37533893
15* REST_18959480_ChIP-ChIP_MESCs_Mouse2.33773778
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30777522
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25862361
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.23295851
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.19495442
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19191445
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17931425
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.15713541
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09035618
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06378000
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05703245
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04110802
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96574156
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86157285
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.84671957
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78914032
31KDM2B_26808549_Chip-Seq_K562_Human1.75888022
32AR_21572438_ChIP-Seq_LNCaP_Human1.75615602
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.69139716
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.58895553
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53779242
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52339273
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47697126
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47416988
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47374663
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46735299
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45432932
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45208225
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43881090
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40484014
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38926050
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38067444
47* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38049246
48ZNF274_21170338_ChIP-Seq_K562_Hela1.33642024
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.32377292
50SMAD4_21799915_ChIP-Seq_A2780_Human1.31356384
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29448628
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27567880
53AHR_22903824_ChIP-Seq_MCF-7_Human1.26928835
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26789992
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26733077
56AR_19668381_ChIP-Seq_PC3_Human1.25554284
57* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24671513
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22629712
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21498088
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19807448
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19479134
62* ARNT_22903824_ChIP-Seq_MCF-7_Human1.15949660
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.14679296
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14080694
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13320290
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10081330
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08978880
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08397342
69STAT3_23295773_ChIP-Seq_U87_Human1.08027917
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.07798247
71* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07661769
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07046937
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06998488
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.06128889
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05435509
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05319988
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05319593
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03821949
79* SMAD3_21741376_ChIP-Seq_ESCs_Human1.03493980
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03287701
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.02758836
82P300_19829295_ChIP-Seq_ESCs_Human1.02630992
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.02325382
84RNF2_27304074_Chip-Seq_NSC_Mouse1.01921641
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00403584
86AR_25329375_ChIP-Seq_VCAP_Human1.00226605
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00033814
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99748119
89* KDM2B_26808549_Chip-Seq_JURKAT_Human0.97966020
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.97055472
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96377300
92* KDM2B_26808549_Chip-Seq_DND41_Human0.95767413
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.95460969
94CTCF_27219007_Chip-Seq_Bcells_Human0.94582571
95FUS_26573619_Chip-Seq_HEK293_Human0.94199047
96* SMAD3_21741376_ChIP-Seq_EPCs_Human0.92729618
97* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91133457
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90900776
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.90871054
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90233225
101ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89962977
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.89829210
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89249409
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88985238
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88985238
106TAF15_26573619_Chip-Seq_HEK293_Human0.88243691
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88022376
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.87736946
109TP53_16413492_ChIP-PET_HCT116_Human0.87470602
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87449061
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87309969
112LXR_22292898_ChIP-Seq_THP-1_Human0.86168897
113* TCF4_23295773_ChIP-Seq_U87_Human0.85813336
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85650034
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85509781
116ISL1_27105846_Chip-Seq_CPCs_Mouse0.85499403
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85430282
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85336713
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85323985
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85004959
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84897716
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84762656
123* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83989012
124CBX2_27304074_Chip-Seq_ESCs_Mouse0.82805610
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82155187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.58365578
2MP0004270_analgesia4.17807771
3MP0003635_abnormal_synaptic_transmissio4.02841344
4MP0003880_abnormal_central_pattern3.84155051
5MP0002063_abnormal_learning/memory/cond3.21133226
6MP0001968_abnormal_touch/_nociception3.18124493
7MP0005423_abnormal_somatic_nervous3.10941950
8MP0009046_muscle_twitch3.07491034
9MP0009745_abnormal_behavioral_response2.96478692
10MP0002734_abnormal_mechanical_nocicepti2.95815910
11MP0002064_seizures2.85228355
12MP0002735_abnormal_chemical_nociception2.62651765
13MP0002572_abnormal_emotion/affect_behav2.56484925
14MP0004858_abnormal_nervous_system2.51745692
15MP0000569_abnormal_digit_pigmentation2.50747420
16MP0002733_abnormal_thermal_nociception2.49256849
17MP0002736_abnormal_nociception_after2.35997220
18MP0000778_abnormal_nervous_system2.32351064
19MP0001486_abnormal_startle_reflex2.29350905
20MP0002272_abnormal_nervous_system2.17595780
21MP0001970_abnormal_pain_threshold2.15834398
22MP0009780_abnormal_chondrocyte_physiolo2.14583175
23MP0001440_abnormal_grooming_behavior2.13311496
24MP0004811_abnormal_neuron_physiology2.13059634
25MP0002184_abnormal_innervation2.09531820
26MP0008877_abnormal_DNA_methylation2.00743809
27MP0003329_amyloid_beta_deposits1.89138233
28MP0002067_abnormal_sensory_capabilities1.88092627
29MP0000955_abnormal_spinal_cord1.87071398
30MP0003123_paternal_imprinting1.86892764
31MP0002909_abnormal_adrenal_gland1.86317510
32MP0008569_lethality_at_weaning1.85493007
33MP0002557_abnormal_social/conspecific_i1.82904673
34MP0001501_abnormal_sleep_pattern1.81566669
35MP0008961_abnormal_basal_metabolism1.70420484
36MP0004924_abnormal_behavior1.58884258
37MP0005386_behavior/neurological_phenoty1.58884258
38MP0010234_abnormal_vibrissa_follicle1.57513931
39MP0004885_abnormal_endolymph1.55359496
40MP0006276_abnormal_autonomic_nervous1.52995183
41MP0002882_abnormal_neuron_morphology1.52114496
42MP0003879_abnormal_hair_cell1.51009560
43MP0010678_abnormal_skin_adnexa1.50422500
44MP0000566_synostosis1.46538395
45MP0003787_abnormal_imprinting1.45207943
46MP0002822_catalepsy1.44134079
47MP0002066_abnormal_motor_capabilities/c1.37745294
48MP0000383_abnormal_hair_follicle1.30831267
49MP0006292_abnormal_olfactory_placode1.30572808
50MP0002152_abnormal_brain_morphology1.29991182
51MP0005645_abnormal_hypothalamus_physiol1.27539611
52MP0002796_impaired_skin_barrier1.26745739
53MP0003122_maternal_imprinting1.25485816
54MP0001984_abnormal_olfaction1.20298517
55MP0003633_abnormal_nervous_system1.19973937
56MP0002653_abnormal_ependyma_morphology1.12064302
57MP0004133_heterotaxia1.08064860
58MP0003283_abnormal_digestive_organ1.06613995
59MP0003631_nervous_system_phenotype1.05823061
60MP0001485_abnormal_pinna_reflex1.05699406
61MP0003172_abnormal_lysosome_physiology1.04435907
62MP0004142_abnormal_muscle_tone1.03808235
63MP0005499_abnormal_olfactory_system1.02454703
64MP0005394_taste/olfaction_phenotype1.02454703
65MP0001502_abnormal_circadian_rhythm1.01657607
66MP0005409_darkened_coat_color0.99208750
67MP0005377_hearing/vestibular/ear_phenot0.95578407
68MP0003878_abnormal_ear_physiology0.95578407
69MP0008057_abnormal_DNA_replication0.94843621
70MP0005551_abnormal_eye_electrophysiolog0.94787583
71MP0003861_abnormal_nervous_system0.94173812
72MP0003632_abnormal_nervous_system0.90415647
73MP0002229_neurodegeneration0.88974341
74MP0009672_abnormal_birth_weight0.88802289
75MP0002069_abnormal_eating/drinking_beha0.88158237
76MP0002098_abnormal_vibrissa_morphology0.86615605
77MP0003937_abnormal_limbs/digits/tail_de0.86481733
78MP0005646_abnormal_pituitary_gland0.85728204
79MP0003938_abnormal_ear_development0.84456653
80MP0003634_abnormal_glial_cell0.83617385
81MP0001348_abnormal_lacrimal_gland0.82656424
82MP0008872_abnormal_physiological_respon0.81469497
83MP0004742_abnormal_vestibular_system0.81444487
84MP0003303_peritoneal_inflammation0.79481259
85MP0009053_abnormal_anal_canal0.78410378
86MP0000631_abnormal_neuroendocrine_gland0.77825875
87MP0000604_amyloidosis0.77811789
88MP0000427_abnormal_hair_cycle0.77799000
89MP0005187_abnormal_penis_morphology0.77548050
90MP0003183_abnormal_peptide_metabolism0.77313868
91MP0002752_abnormal_somatic_nervous0.77072059
92MP0008874_decreased_physiological_sensi0.75539956
93MP0001177_atelectasis0.72804562
94MP0003119_abnormal_digestive_system0.72547245
95MP0002081_perinatal_lethality0.72446463
96MP0005623_abnormal_meninges_morphology0.69958701
97MP0003941_abnormal_skin_development0.69651314
98MP0000762_abnormal_tongue_morphology0.69387855
99MP0004233_abnormal_muscle_weight0.68773697
100MP0003693_abnormal_embryo_hatching0.68219111
101MP0008789_abnormal_olfactory_epithelium0.67538585
102MP0003890_abnormal_embryonic-extraembry0.66006581
103MP0001944_abnormal_pancreas_morphology0.65173236
104MP0001963_abnormal_hearing_physiology0.64780775
105MP0001943_abnormal_respiration0.64175293
106MP0003755_abnormal_palate_morphology0.63942961
107MP0010769_abnormal_survival0.63080657
108MP0004145_abnormal_muscle_electrophysio0.61505872
109MP0005167_abnormal_blood-brain_barrier0.61068133
110MP0000751_myopathy0.61018235
111MP0001299_abnormal_eye_distance/0.60327549
112MP0000579_abnormal_nail_morphology0.60162937
113MP0001905_abnormal_dopamine_level0.60069262
114MP0010770_preweaning_lethality0.60004535
115MP0002082_postnatal_lethality0.60004535
116MP0010768_mortality/aging0.59785268
117MP0000537_abnormal_urethra_morphology0.59319979
118MP0003075_altered_response_to0.59104073
119MP0001188_hyperpigmentation0.57641067
120MP0003121_genomic_imprinting0.57326764
121MP0004085_abnormal_heartbeat0.56932004
122MP0003690_abnormal_glial_cell0.56270362
123MP0002089_abnormal_postnatal_growth/wei0.55953469
124MP0001529_abnormal_vocalization0.55290924
125MP0004510_myositis0.54870891
126MP0001664_abnormal_digestion0.53011810
127MP0002234_abnormal_pharynx_morphology0.52742324

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.78745810
2Focal motor seizures (HP:0011153)5.52000367
3Focal seizures (HP:0007359)5.00166422
4Visual hallucinations (HP:0002367)4.86232234
5Epileptic encephalopathy (HP:0200134)3.98657201
6Progressive cerebellar ataxia (HP:0002073)3.96076805
7Supranuclear gaze palsy (HP:0000605)3.93423105
8Mutism (HP:0002300)3.81447674
9Ankle clonus (HP:0011448)3.76679340
10Action tremor (HP:0002345)3.70748175
11Papilledema (HP:0001085)3.65988585
12Febrile seizures (HP:0002373)3.52448717
13Atonic seizures (HP:0010819)3.46831715
14Absence seizures (HP:0002121)3.34049040
15Urinary bladder sphincter dysfunction (HP:0002839)3.26206022
16Amyotrophic lateral sclerosis (HP:0007354)3.13997503
17Abnormality of the lower motor neuron (HP:0002366)3.13439418
18Generalized tonic-clonic seizures (HP:0002069)3.05330326
19Broad-based gait (HP:0002136)3.04881025
20Poor eye contact (HP:0000817)3.03791725
21Dialeptic seizures (HP:0011146)3.03188878
22Genetic anticipation (HP:0003743)2.99118784
23Impaired vibration sensation in the lower limbs (HP:0002166)2.94712630
24Urinary urgency (HP:0000012)2.94201732
25Abnormal social behavior (HP:0012433)2.84785033
26Impaired social interactions (HP:0000735)2.84785033
27Abnormal eating behavior (HP:0100738)2.83137798
28Abnormality of the corticospinal tract (HP:0002492)2.80131237
29Truncal ataxia (HP:0002078)2.76262782
30Depression (HP:0000716)2.75055878
31Termporal pattern (HP:0011008)2.73052009
32Insidious onset (HP:0003587)2.73052009
33Amblyopia (HP:0000646)2.72735860
34Gaze-evoked nystagmus (HP:0000640)2.71901315
35Drooling (HP:0002307)2.66710378
36Excessive salivation (HP:0003781)2.66710378
37Postural instability (HP:0002172)2.61035755
38Insomnia (HP:0100785)2.60532791
39Dysdiadochokinesis (HP:0002075)2.60504422
40Impaired smooth pursuit (HP:0007772)2.60212007
41Spastic gait (HP:0002064)2.58495059
42Diplopia (HP:0000651)2.55726055
43Abnormality of binocular vision (HP:0011514)2.55726055
44Hyperacusis (HP:0010780)2.54689047
45Abnormality of nail color (HP:0100643)2.54587492
46Polyphagia (HP:0002591)2.52896465
47Inappropriate behavior (HP:0000719)2.51412007
48Hemiparesis (HP:0001269)2.49329678
49Dysmetria (HP:0001310)2.39761109
50Stereotypic behavior (HP:0000733)2.38050483
51Abnormality of ocular smooth pursuit (HP:0000617)2.37365692
52Cerebral inclusion bodies (HP:0100314)2.36961083
53Pointed chin (HP:0000307)2.36511851
54Obstructive sleep apnea (HP:0002870)2.36309396
55Failure to thrive in infancy (HP:0001531)2.35821264
56Apathy (HP:0000741)2.34063785
57Megalencephaly (HP:0001355)2.29785863
58Ventricular fibrillation (HP:0001663)2.28158275
59Limb dystonia (HP:0002451)2.26935807
60Intention tremor (HP:0002080)2.26735412
61Neurofibrillary tangles (HP:0002185)2.25556096
62Hemiplegia (HP:0002301)2.25309203
63Aqueductal stenosis (HP:0002410)2.23759440
64Progressive inability to walk (HP:0002505)2.20340387
65Lower limb muscle weakness (HP:0007340)2.17128961
66Macroorchidism (HP:0000053)2.17057260
67Agitation (HP:0000713)2.13934869
68Elfin facies (HP:0004428)2.13813287
69Labial hypoplasia (HP:0000066)2.13204829
70EEG with generalized epileptiform discharges (HP:0011198)2.11463267
71Epileptiform EEG discharges (HP:0011182)2.11290178
72Akinesia (HP:0002304)2.11150274
73Bradykinesia (HP:0002067)2.10970664
74Hypsarrhythmia (HP:0002521)2.07371964
75Volvulus (HP:0002580)2.06934907
76Torticollis (HP:0000473)2.06875894
77Neuronal loss in central nervous system (HP:0002529)2.04514104
78Anxiety (HP:0000739)2.04366335
79Absent speech (HP:0001344)2.04098786
80Diminished motivation (HP:0000745)2.04029320
81Fetal akinesia sequence (HP:0001989)2.03027034
82Morphological abnormality of the pyramidal tract (HP:0002062)2.01343337
83Lower limb amyotrophy (HP:0007210)2.00734636
84Annular pancreas (HP:0001734)1.99763258
85Lissencephaly (HP:0001339)1.99387157
86Oligodontia (HP:0000677)1.98511651
87Clonus (HP:0002169)1.98326034
88Hypoplasia of the brainstem (HP:0002365)1.96309815
89Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96309815
90Inability to walk (HP:0002540)1.93650578
91Abnormality of the astrocytes (HP:0100707)1.93355948
92Astrocytoma (HP:0009592)1.93355948
93Overriding aorta (HP:0002623)1.93002945
94Abnormality of the labia minora (HP:0012880)1.92200097
95Status epilepticus (HP:0002133)1.91940726
96Fragile nails (HP:0001808)1.91534322
97Hypoplastic labia majora (HP:0000059)1.91320784
98Hypoplastic female external genitalia (HP:0012815)1.90219427
99Bronchomalacia (HP:0002780)1.89929064
100Hepatoblastoma (HP:0002884)1.88852683
101Impaired vibratory sensation (HP:0002495)1.88575588
102Hyperventilation (HP:0002883)1.88082707
103Cutaneous finger syndactyly (HP:0010554)1.88020263
104Lip pit (HP:0100267)1.86598570
105Ankyloglossia (HP:0010296)1.86199724
106Sleep apnea (HP:0010535)1.85311516
107Focal dystonia (HP:0004373)1.82799106
108Scanning speech (HP:0002168)1.81358930
109Plantar hyperkeratosis (HP:0007556)1.81065326
110Intellectual disability, profound (HP:0002187)1.80923132
111Dysmetric saccades (HP:0000641)1.80800280
112Rapidly progressive (HP:0003678)1.79460325
113Exotropia (HP:0000577)1.78989727
114Abnormal pancreas size (HP:0012094)1.78144092
115Optic nerve hypoplasia (HP:0000609)1.75096469
116Abnormality of the nasal septum (HP:0000419)1.74216961
117Abnormality of salivation (HP:0100755)1.72178520
118Shawl scrotum (HP:0000049)1.69329001
119Cutaneous syndactyly (HP:0012725)1.66673276
120Slow-growing hair (HP:0002217)1.65668875
121Abnormality of hair growth rate (HP:0011363)1.65668875
122Onycholysis (HP:0001806)1.64391972
123Abnormality of the labia majora (HP:0012881)1.64253842
124Hypoplasia of dental enamel (HP:0006297)1.63192421
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63111448
126Aplasia involving bones of the extremities (HP:0009825)1.60950702
127Aplasia involving bones of the upper limbs (HP:0009823)1.60950702
128Aplasia of the phalanges of the hand (HP:0009802)1.60950702
129Partial agenesis of the corpus callosum (HP:0001338)1.60154402
130Truncal obesity (HP:0001956)1.58690384
131Spastic tetraparesis (HP:0001285)1.58120395
132Hypotrichosis (HP:0001006)1.57993731
133Absent eyelashes (HP:0000561)1.57697042
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.57326466
135Protruding tongue (HP:0010808)1.55702344
136Palmoplantar hyperkeratosis (HP:0000972)1.55677702
137Muscular hypotonia of the trunk (HP:0008936)1.55477919
138Gastroesophageal reflux (HP:0002020)1.55094438
139Milia (HP:0001056)1.54489985
140Pachygyria (HP:0001302)1.53526097
141Confusion (HP:0001289)1.50331043
142Absent eyebrow (HP:0002223)1.49037965
143Obsessive-compulsive behavior (HP:0000722)1.48950848
144Palmar hyperkeratosis (HP:0010765)1.48223468
145Abnormality of the aortic arch (HP:0012303)1.43937071
146Abnormality of the labia (HP:0000058)1.43618276
147Oligodactyly (hands) (HP:0001180)1.43407668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.39248432
2NTRK33.91391834
3MAP3K43.10407191
4MINK12.93700440
5EPHA42.54371211
6PAK62.52167160
7DAPK22.51981759
8NTRK22.51316232
9MAP2K72.17246642
10LATS22.10196806
11EPHA22.07168387
12KSR22.03856974
13MAP2K41.93748183
14* MAP3K91.91712921
15CAMKK11.90865145
16NTRK11.88514532
17MAP3K121.83320489
18PRKD31.77561625
19SIK21.74443174
20KSR11.69685480
21TYRO31.66889999
22TAF11.62553563
23TAOK11.56389249
24CDK51.55297473
25PHKG11.52753245
26PHKG21.52753245
27MAP3K21.52298660
28MAPK131.51288334
29DAPK11.49110363
30GRK51.40077426
31UHMK11.38860702
32STK381.37020817
33ARAF1.36205258
34MST1R1.33305055
35ALK1.30459829
36RIPK41.25193200
37PNCK1.22435336
38CDK191.19320109
39STK111.18389109
40RET1.16071016
41MET1.05619586
42CAMK1D1.05377686
43FRK1.02614191
44LMTK21.01327211
45RIPK11.01181623
46TSSK60.99803787
47PRKCG0.97244714
48WNK30.96999847
49CDK180.93888715
50SCYL20.93849965
51PRPF4B0.93402665
52PLK20.93372750
53CDK150.92665921
54MARK20.91968000
55PINK10.90956512
56ICK0.90424762
57BMPR1B0.90175048
58CDK140.88392608
59CSNK1G20.87515514
60CAMK1G0.86813939
61CASK0.84885466
62DYRK20.83312473
63BCR0.82875353
64CDK11A0.82248976
65FGFR20.81961253
66CAMKK20.78678385
67ERBB30.77992345
68PAK30.77135975
69BRAF0.72907482
70GRK10.71340874
71DYRK1A0.69931614
72RPS6KA20.69554204
73PRKCZ0.68785729
74OXSR10.68584369
75CAMK10.68356000
76PRKCH0.66260943
77MAP3K60.64909851
78SGK30.64741958
79FES0.64656733
80CDC42BPA0.62506108
81CSNK1G10.62416740
82SGK4940.61235933
83SGK2230.61235933
84SGK10.60715351
85CAMK2A0.60457839
86TNIK0.59520938
87NEK10.59020252
88WNK40.58887224
89FER0.58778049
90STK390.58631781
91LATS10.58506856
92PRKCE0.57524844
93SIK10.56952400
94CSNK1G30.56436646
95NEK60.55656939
96PRKCI0.55241365
97FYN0.53932207
98MAPK100.51548602
99RPS6KB10.51125639
100MAP2K60.51039571
101STK38L0.50504220
102CSNK1A1L0.50398640
103SGK20.50297784
104PDK10.49381582
105RPS6KA30.48762143
106FGFR10.48191631
107LIMK10.45862411
108CAMK40.44995235
109TRIM280.44490481
110MKNK20.43704235
111PDPK10.41929951
112WNK10.41917084
113PRKAA10.41778998
114FGR0.41484716
115AURKA0.41173902
116ERBB20.41024609
117PRKDC0.39009549
118PDGFRA0.38792962
119MAP3K10.38285185
120PTK20.37666229
121CCNB10.37195192
122BRSK10.36322811
123MAPK80.35348599
124MAPK120.35336272
125CSNK1E0.33773908
126MAP3K70.32348217
127MAPK90.31316708
128MATK0.31034343
129RAF10.30676511
130GSK3B0.30573027
131CAMK2B0.29265094
132TRIB30.28217719
133PRKCB0.27580234
134CSNK1D0.27342558

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.13451996
2Nicotine addiction_Homo sapiens_hsa050333.01371365
3Long-term potentiation_Homo sapiens_hsa047202.35954077
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33578889
5Olfactory transduction_Homo sapiens_hsa047402.31615221
6Circadian entrainment_Homo sapiens_hsa047132.30893837
7Glutamatergic synapse_Homo sapiens_hsa047242.23952434
8GABAergic synapse_Homo sapiens_hsa047272.21982695
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20501183
10Morphine addiction_Homo sapiens_hsa050322.04908236
11Dopaminergic synapse_Homo sapiens_hsa047281.99426065
12Salivary secretion_Homo sapiens_hsa049701.95360374
13Amphetamine addiction_Homo sapiens_hsa050311.92921056
14Gastric acid secretion_Homo sapiens_hsa049711.81139217
15Insulin secretion_Homo sapiens_hsa049111.79416898
16Cholinergic synapse_Homo sapiens_hsa047251.76695504
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67883273
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63613389
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62572518
20Long-term depression_Homo sapiens_hsa047301.57929695
21GnRH signaling pathway_Homo sapiens_hsa049121.57116735
22Oxytocin signaling pathway_Homo sapiens_hsa049211.54449402
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48822770
24Taste transduction_Homo sapiens_hsa047421.46682132
25Renin secretion_Homo sapiens_hsa049241.46286441
26Gap junction_Homo sapiens_hsa045401.43688319
27Axon guidance_Homo sapiens_hsa043601.42776322
28Estrogen signaling pathway_Homo sapiens_hsa049151.41745450
29Type II diabetes mellitus_Homo sapiens_hsa049301.40481330
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39806825
31Vitamin B6 metabolism_Homo sapiens_hsa007501.37478955
32Glioma_Homo sapiens_hsa052141.36505347
33Serotonergic synapse_Homo sapiens_hsa047261.36191878
34ErbB signaling pathway_Homo sapiens_hsa040121.34220820
35Cocaine addiction_Homo sapiens_hsa050301.33706050
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29751219
37Calcium signaling pathway_Homo sapiens_hsa040201.21944738
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.19883276
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19733817
40Dorso-ventral axis formation_Homo sapiens_hsa043201.15545912
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.10209249
42cAMP signaling pathway_Homo sapiens_hsa040241.09902892
43mTOR signaling pathway_Homo sapiens_hsa041501.08221575
44Melanogenesis_Homo sapiens_hsa049161.07073443
45Oocyte meiosis_Homo sapiens_hsa041141.06313775
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06073790
47Endometrial cancer_Homo sapiens_hsa052131.05721057
48VEGF signaling pathway_Homo sapiens_hsa043701.01226408
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99015988
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.98181935
51Collecting duct acid secretion_Homo sapiens_hsa049660.97749102
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91681702
53Choline metabolism in cancer_Homo sapiens_hsa052310.91172264
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90606640
55MAPK signaling pathway_Homo sapiens_hsa040100.89380165
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88808610
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87141996
58Butanoate metabolism_Homo sapiens_hsa006500.86476196
59Colorectal cancer_Homo sapiens_hsa052100.85483717
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84719766
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82518084
62Renal cell carcinoma_Homo sapiens_hsa052110.80472052
63Pancreatic secretion_Homo sapiens_hsa049720.79916513
64Basal cell carcinoma_Homo sapiens_hsa052170.79808500
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76985786
66Fatty acid biosynthesis_Homo sapiens_hsa000610.75685795
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75650566
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75232800
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.75186427
70Endocytosis_Homo sapiens_hsa041440.74711473
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73991747
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73290313
73Thyroid hormone synthesis_Homo sapiens_hsa049180.73002665
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72731878
75Rap1 signaling pathway_Homo sapiens_hsa040150.72019729
76Non-small cell lung cancer_Homo sapiens_hsa052230.71478281
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.71336788
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70941299
79Insulin signaling pathway_Homo sapiens_hsa049100.70893129
80Inositol phosphate metabolism_Homo sapiens_hsa005620.68819094
81Ras signaling pathway_Homo sapiens_hsa040140.68156386
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67850991
83Vibrio cholerae infection_Homo sapiens_hsa051100.66747452
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65484454
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65191797
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64982412
87Adherens junction_Homo sapiens_hsa045200.64881176
88Selenocompound metabolism_Homo sapiens_hsa004500.63345718
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63002331
90Ovarian steroidogenesis_Homo sapiens_hsa049130.62885417
91Wnt signaling pathway_Homo sapiens_hsa043100.62105651
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61392653
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61104979
94Dilated cardiomyopathy_Homo sapiens_hsa054140.58461566
95Phototransduction_Homo sapiens_hsa047440.56261190
96Sphingolipid metabolism_Homo sapiens_hsa006000.56141174
97Steroid biosynthesis_Homo sapiens_hsa001000.55608472
98Alcoholism_Homo sapiens_hsa050340.55003118
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54078873
100Hippo signaling pathway_Homo sapiens_hsa043900.53618796
101Glucagon signaling pathway_Homo sapiens_hsa049220.52656808
102Prolactin signaling pathway_Homo sapiens_hsa049170.52648561
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52638632
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51332464
105Basal transcription factors_Homo sapiens_hsa030220.50824352
106Chemokine signaling pathway_Homo sapiens_hsa040620.50790210
107Tight junction_Homo sapiens_hsa045300.48290084
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48165401
109Thyroid cancer_Homo sapiens_hsa052160.46115419
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.45984628
111Lysine degradation_Homo sapiens_hsa003100.45583680
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45449539
113Cardiac muscle contraction_Homo sapiens_hsa042600.45298016
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43301046
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43237458
116AMPK signaling pathway_Homo sapiens_hsa041520.42718990
117mRNA surveillance pathway_Homo sapiens_hsa030150.42273603
118Ether lipid metabolism_Homo sapiens_hsa005650.41773140
119Circadian rhythm_Homo sapiens_hsa047100.39787159
120Hedgehog signaling pathway_Homo sapiens_hsa043400.39425466
121Chronic myeloid leukemia_Homo sapiens_hsa052200.38176494
122Platelet activation_Homo sapiens_hsa046110.37723948
123Bile secretion_Homo sapiens_hsa049760.36923455
124Histidine metabolism_Homo sapiens_hsa003400.36213332
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35048498
126beta-Alanine metabolism_Homo sapiens_hsa004100.33672960

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