MAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.72927244
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62276270
3positive regulation of synapse maturation (GO:0090129)4.45189589
4synaptic vesicle maturation (GO:0016188)4.36194020
5synaptic vesicle exocytosis (GO:0016079)4.11027012
6muscle filament sliding (GO:0030049)4.06668405
7actin-myosin filament sliding (GO:0033275)4.06668405
8RNA destabilization (GO:0050779)3.94623240
9locomotory exploration behavior (GO:0035641)3.84254997
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79081120
11protein localization to synapse (GO:0035418)3.78051460
12vocalization behavior (GO:0071625)3.75423128
13cytoskeletal anchoring at plasma membrane (GO:0007016)3.65586401
14glutamate secretion (GO:0014047)3.64375322
15neuronal action potential propagation (GO:0019227)3.62128423
16regulation of synapse maturation (GO:0090128)3.61880505
17cardiac myofibril assembly (GO:0055003)3.58353868
18sarcoplasmic reticulum calcium ion transport (GO:0070296)3.57251924
19ribosome assembly (GO:0042255)3.56519325
20cellular potassium ion homeostasis (GO:0030007)3.54599907
21actin-mediated cell contraction (GO:0070252)3.54514332
22neuron cell-cell adhesion (GO:0007158)3.50805178
23histone H4-K12 acetylation (GO:0043983)3.48692046
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.47668999
25regulation of synaptic vesicle exocytosis (GO:2000300)3.47633925
26sarcomere organization (GO:0045214)3.47472239
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.47463960
28neurotransmitter secretion (GO:0007269)3.45281217
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37968148
30protein-cofactor linkage (GO:0018065)3.36877109
31myofibril assembly (GO:0030239)3.35461197
32mRNA modification (GO:0016556)3.35149547
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34559775
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.27926933
35layer formation in cerebral cortex (GO:0021819)3.26876605
36deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.26536109
37cardiac muscle contraction (GO:0060048)3.24353288
38neuromuscular process controlling posture (GO:0050884)3.23284714
39cell communication by electrical coupling (GO:0010644)3.22457367
40response to pheromone (GO:0019236)3.21924812
41long-term memory (GO:0007616)3.21591584
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20147224
43regulation of synaptic vesicle transport (GO:1902803)3.16603624
44synaptic transmission, glutamatergic (GO:0035249)3.14794646
45sodium ion export (GO:0071436)3.14611849
46positive regulation of potassium ion transport (GO:0043268)3.14391239
47regulation of centriole replication (GO:0046599)3.13967592
48negative regulation of microtubule polymerization (GO:0031115)3.13595680
49ionotropic glutamate receptor signaling pathway (GO:0035235)3.13074579
50peristalsis (GO:0030432)3.12338787
51exploration behavior (GO:0035640)3.12048095
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11040985
53neuron-neuron synaptic transmission (GO:0007270)3.10116477
54regulation of synapse structural plasticity (GO:0051823)3.08001938
55regulation of cell communication by electrical coupling (GO:0010649)3.07182988
56neuromuscular synaptic transmission (GO:0007274)3.04811307
57cell-substrate junction assembly (GO:0007044)3.04418250
58regulation of glutamate receptor signaling pathway (GO:1900449)3.04181366
59adherens junction assembly (GO:0034333)3.03048340
60glutamate receptor signaling pathway (GO:0007215)2.99743919
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96067172
62hemidesmosome assembly (GO:0031581)2.96062764
63actin filament-based movement (GO:0030048)2.96033124
64positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.95454617
65cell-substrate adherens junction assembly (GO:0007045)2.95393813
66focal adhesion assembly (GO:0048041)2.95393813
67regulation of translational termination (GO:0006449)2.94004034
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92649878
69regulation of actin filament-based movement (GO:1903115)2.91838181
70neurofilament cytoskeleton organization (GO:0060052)2.91750359
71cell migration in hindbrain (GO:0021535)2.91138435
72striated muscle contraction (GO:0006941)2.90783958
73regulation of the force of heart contraction (GO:0002026)2.90114064
74actomyosin structure organization (GO:0031032)2.88783045
75regulation of neuronal synaptic plasticity (GO:0048168)2.88678635
76neurotransmitter transport (GO:0006836)2.86008912
77neuron recognition (GO:0008038)2.83408546
78DNA damage induced protein phosphorylation (GO:0006975)2.82893183
79innervation (GO:0060384)2.80793890
80neuromuscular process controlling balance (GO:0050885)2.79327371
81regulation of vesicle fusion (GO:0031338)2.75876577
82regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.74401507
83regulation of sodium ion transmembrane transport (GO:1902305)2.74354572
84regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74264927
85lateral ventricle development (GO:0021670)2.72660346
86dendritic spine morphogenesis (GO:0060997)2.71773307
87axonal fasciculation (GO:0007413)2.71330396
88response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.70885634
89regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.69911351
90myelination in peripheral nervous system (GO:0022011)2.68144554
91peripheral nervous system axon ensheathment (GO:0032292)2.68144554
92membrane hyperpolarization (GO:0060081)2.66937342
93regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.65800256
94cerebellar Purkinje cell differentiation (GO:0021702)2.65121799
95cardiac muscle hypertrophy (GO:0003300)2.64872753
96membrane depolarization during action potential (GO:0086010)2.64799695
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64587350
98regulation of relaxation of muscle (GO:1901077)2.62882776
99cerebellar granule cell differentiation (GO:0021707)2.62279991
100regulation of neurotransmitter levels (GO:0001505)2.60878952
101spindle assembly involved in mitosis (GO:0090307)2.58148730
102potassium ion homeostasis (GO:0055075)2.57628232
103establishment of mitochondrion localization (GO:0051654)2.57361355
104synaptic vesicle endocytosis (GO:0048488)2.56426828
105regulation of postsynaptic membrane potential (GO:0060078)2.56284295
106neuromuscular process (GO:0050905)2.55342777
107protein heterotrimerization (GO:0070208)2.55341254
108activation of protein kinase A activity (GO:0034199)2.55065640
109negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.55057334
110mitochondrion transport along microtubule (GO:0047497)2.54870356
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.54870356
112plasma membrane repair (GO:0001778)2.54822226
113transmission of nerve impulse (GO:0019226)2.54310561
114postsynaptic membrane organization (GO:0001941)2.53525650
115positive regulation of potassium ion transmembrane transport (GO:1901381)2.53222622
116mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.52922072
117skin morphogenesis (GO:0043589)2.52216689
118positive regulation of membrane potential (GO:0045838)2.52019987
119histone H4-K5 acetylation (GO:0043981)2.51284791
120histone H4-K8 acetylation (GO:0043982)2.51284791
121regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50846027
122protein targeting to plasma membrane (GO:0072661)2.50333376
123striated muscle hypertrophy (GO:0014897)2.49819160
124axon cargo transport (GO:0008088)2.49771046
125cell communication involved in cardiac conduction (GO:0086065)2.49595973
126gamma-aminobutyric acid signaling pathway (GO:0007214)2.47573512
127righting reflex (GO:0060013)2.47446332
128regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47387089
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.46218781
130regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.45933880
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.45413674
132positive regulation of sodium ion transport (GO:0010765)2.45408915
133positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.45365884
134organelle transport along microtubule (GO:0072384)2.44661807
135protein retention in ER lumen (GO:0006621)2.42429263
136muscle contraction (GO:0006936)2.41605293
137positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.41537657
138actin filament depolymerization (GO:0030042)2.40427900
139adult walking behavior (GO:0007628)2.40221445
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.40008020
141collagen fibril organization (GO:0030199)2.39982764
142maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39891526
143axon extension (GO:0048675)2.39213317
144stress fiber assembly (GO:0043149)2.38699918
145negative regulation of potassium ion transmembrane transport (GO:1901380)2.38131097
146cellular sodium ion homeostasis (GO:0006883)2.37158511
147cell adhesion mediated by integrin (GO:0033627)2.36095677
148planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35219050
149negative regulation of catenin import into nucleus (GO:0035414)2.34799902
150neuronal ion channel clustering (GO:0045161)2.34381509
151regulation of early endosome to late endosome transport (GO:2000641)2.34008335
152amino acid import (GO:0043090)2.33998622
153regulation of NFAT protein import into nucleus (GO:0051532)2.32869151
154myoblast fusion (GO:0007520)2.32763101
155cellular response to monoamine stimulus (GO:0071868)2.32516837
156cellular response to catecholamine stimulus (GO:0071870)2.32516837
157endodermal cell differentiation (GO:0035987)2.30353459
158regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.30281499
159regulation of cardiac muscle cell contraction (GO:0086004)2.29653124
160barbed-end actin filament capping (GO:0051016)2.29602404
161retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.28398400
162paraxial mesoderm development (GO:0048339)2.28095675
163protein localization to endosome (GO:0036010)2.27546806
164membrane assembly (GO:0071709)2.26516424
165basement membrane organization (GO:0071711)2.25997149
166cardiac muscle adaptation (GO:0014887)2.25761761
167cardiac muscle hypertrophy in response to stress (GO:0014898)2.25761761
168muscle hypertrophy in response to stress (GO:0003299)2.25761761
169response to inactivity (GO:0014854)2.25483051
170regulation of calcium ion transmembrane transport (GO:1903169)2.24481414
171regulation of calcium ion transmembrane transporter activity (GO:1901019)2.24481414
172cell migration involved in heart development (GO:0060973)2.24363294
173Golgi transport vesicle coating (GO:0048200)2.24167448
174COPI coating of Golgi vesicle (GO:0048205)2.24167448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03923279
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.17468634
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15965276
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78029108
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.71824138
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65917620
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.64460807
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43050487
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40872895
10REST_21632747_ChIP-Seq_MESCs_Mouse2.40017478
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.30542167
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29018984
13CLOCK_20551151_ChIP-Seq_293T_Human2.21323334
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21234492
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19029805
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16296911
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14348474
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.10970775
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09217865
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.09018592
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.07411401
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.04189312
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02620676
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02620676
25GATA1_26923725_Chip-Seq_HPCs_Mouse2.01495430
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00577124
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00134050
28DROSHA_22980978_ChIP-Seq_HELA_Human1.99712524
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96782177
30CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.93993954
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93617577
32GBX2_23144817_ChIP-Seq_PC3_Human1.92642341
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.89475621
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.84993502
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81919108
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80976672
37KDM2B_26808549_Chip-Seq_K562_Human1.79840229
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.78033903
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77728216
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77095465
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76900940
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76650425
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73837651
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.73100625
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.73100625
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68927086
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64316582
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62708517
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.60964039
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59291857
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.58220110
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.56330167
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.55996003
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55979953
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.54847833
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52685221
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52148579
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49087829
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48878616
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44474954
61ZNF263_19887448_ChIP-Seq_K562_Human1.42942190
62LXR_22292898_ChIP-Seq_THP-1_Human1.42855383
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40936476
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38897303
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38243342
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37829914
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37217323
68OCT4_19829295_ChIP-Seq_ESCs_Human1.33995381
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32713280
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32093419
71TP53_23651856_ChIP-Seq_MEFs_Mouse1.31736805
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30067643
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29326209
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29075962
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28411843
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27365853
77ZNF274_21170338_ChIP-Seq_K562_Hela1.26637250
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26617533
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.22820837
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22368466
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.21287232
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19759375
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18981619
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18092871
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16896308
86RACK7_27058665_Chip-Seq_MCF-7_Human1.16649641
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16438739
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15562932
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.12951512
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12310696
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10302994
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09304891
93* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08276505
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07258576
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06827517
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.06449098
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05152825
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04570402
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04180674
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.04020294
101KDM2B_26808549_Chip-Seq_DND41_Human1.03798728
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.03540276
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.03359303
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02823277
105TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01911397
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99727830
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97197387
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97003680
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96668653
110CTCF_27219007_Chip-Seq_Bcells_Human0.96489853
111CJUN_26792858_Chip-Seq_BT549_Human0.95780013
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95607067
113MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95490473
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94728503
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94535999
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94291065
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93136439
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92442226
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92403659
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.92362325
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.92219389
122SMAD_19615063_ChIP-ChIP_OVARY_Human0.91790268
123BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91134626
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89080515
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89009694
126* TP53_22127205_ChIP-Seq_IMR90_Human0.88669130
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.88254367
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87987591
129SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87769322
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.87098475
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86476822
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85797708
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85492239
134CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83815496
135EOMES_21245162_ChIP-Seq_HESCs_Human0.82845596
136CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82635522
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.82125118
138POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81945182
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81884350
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81275112
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.81243845
142SMAD4_21741376_ChIP-Seq_ESCs_Human0.81156079
143SMAD4_21799915_ChIP-Seq_A2780_Human0.81152273
144SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80632175
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80275448
146SOX9_26525672_Chip-Seq_HEART_Mouse0.80091755
147KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79398784
148KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79398784
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79398784
150E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79010572
151FUS_26573619_Chip-Seq_HEK293_Human0.78765321
152YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75505118
153KLF4_19829295_ChIP-Seq_ESCs_Human0.75312483
154NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.74525510
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.73923508
156NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73419273
157SMC4_20622854_ChIP-Seq_HELA_Human0.73350784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.75835172
2MP0008438_abnormal_cutaneous_collagen4.08508287
3MP0003880_abnormal_central_pattern3.57138815
4MP0004270_analgesia3.29088532
5MP0003705_abnormal_hypodermis_morpholog3.26594840
6MP0003635_abnormal_synaptic_transmissio3.16008322
7MP0005423_abnormal_somatic_nervous2.93501155
8MP0009046_muscle_twitch2.71021824
9MP0004272_abnormal_basement_membrane2.47717020
10MP0002734_abnormal_mechanical_nocicepti2.40870651
11MP0002064_seizures2.39233518
12MP0002063_abnormal_learning/memory/cond2.37696819
13MP0009745_abnormal_behavioral_response2.33616874
14MP0000751_myopathy2.31783915
15MP0005275_abnormal_skin_tensile2.29663764
16MP0009780_abnormal_chondrocyte_physiolo2.27986085
17MP0002272_abnormal_nervous_system2.20427452
18MP0001968_abnormal_touch/_nociception2.16207790
19MP0001958_emphysema2.11413585
20MP0004145_abnormal_muscle_electrophysio2.06037116
21MP0003329_amyloid_beta_deposits2.02669268
22MP0002735_abnormal_chemical_nociception1.99689042
23MP0003566_abnormal_cell_adhesion1.98827532
24MP0005503_abnormal_tendon_morphology1.98276047
25MP0003279_aneurysm1.97604825
26MP0002572_abnormal_emotion/affect_behav1.95327529
27MP0002184_abnormal_innervation1.92392288
28MP0005257_abnormal_intraocular_pressure1.89132369
29MP0001486_abnormal_startle_reflex1.87814840
30MP0001440_abnormal_grooming_behavior1.87545964
31MP0003646_muscle_fatigue1.81265439
32MP0005623_abnormal_meninges_morphology1.64492838
33MP0000733_abnormal_muscle_development1.58862447
34MP0000955_abnormal_spinal_cord1.58825714
35MP0002837_dystrophic_cardiac_calcinosis1.57058743
36MP0004084_abnormal_cardiac_muscle1.56972323
37MP0006276_abnormal_autonomic_nervous1.56366840
38MP0001970_abnormal_pain_threshold1.55658766
39MP0002108_abnormal_muscle_morphology1.54898993
40MP0010368_abnormal_lymphatic_system1.54739827
41MP0002736_abnormal_nociception_after1.53607066
42MP0005409_darkened_coat_color1.52698435
43MP0002067_abnormal_sensory_capabilities1.51208986
44MP0004924_abnormal_behavior1.51200451
45MP0005386_behavior/neurological_phenoty1.51200451
46MP0005551_abnormal_eye_electrophysiolog1.50747804
47MP0008569_lethality_at_weaning1.50098432
48MP0006138_congestive_heart_failure1.48739964
49MP0002269_muscular_atrophy1.47209514
50MP0000778_abnormal_nervous_system1.46984808
51MP0004215_abnormal_myocardial_fiber1.46736912
52MP0008877_abnormal_DNA_methylation1.45980955
53MP0003091_abnormal_cell_migration1.43652021
54MP0004142_abnormal_muscle_tone1.42683043
55MP0000579_abnormal_nail_morphology1.41963022
56MP0002882_abnormal_neuron_morphology1.41645495
57MP0002733_abnormal_thermal_nociception1.41059927
58MP0004811_abnormal_neuron_physiology1.40634199
59MP0004130_abnormal_muscle_cell1.40095877
60MP0000003_abnormal_adipose_tissue1.34530149
61MP0001529_abnormal_vocalization1.34283212
62MP0010630_abnormal_cardiac_muscle1.34096405
63MP0002877_abnormal_melanocyte_morpholog1.32962808
64MP0004510_myositis1.31910520
65MP0003879_abnormal_hair_cell1.29572705
66MP0004233_abnormal_muscle_weight1.28569016
67MP0000534_abnormal_ureter_morphology1.27966182
68MP0003137_abnormal_impulse_conducting1.26393245
69MP0004036_abnormal_muscle_relaxation1.24052097
70MP0005670_abnormal_white_adipose1.23389373
71MP0004858_abnormal_nervous_system1.22919749
72MP0000749_muscle_degeneration1.22304492
73MP0000747_muscle_weakness1.21337989
74MP0004885_abnormal_endolymph1.20630176
75MP0002066_abnormal_motor_capabilities/c1.19917853
76MP0006072_abnormal_retinal_apoptosis1.18793900
77MP0000762_abnormal_tongue_morphology1.15576636
78MP0001348_abnormal_lacrimal_gland1.13896782
79MP0001501_abnormal_sleep_pattern1.13885484
80MP0002557_abnormal_social/conspecific_i1.12735070
81MP0002822_catalepsy1.10264528
82MP0002896_abnormal_bone_mineralization1.09473866
83MP0009384_cardiac_valve_regurgitation1.08295337
84MP0002752_abnormal_somatic_nervous1.07406828
85MP0010030_abnormal_orbit_morphology1.07144705
86MP0005620_abnormal_muscle_contractility1.06268781
87MP0001905_abnormal_dopamine_level1.05831074
88MP0002229_neurodegeneration1.05269928
89MP0000767_abnormal_smooth_muscle1.03192282
90MP0002152_abnormal_brain_morphology1.02659931
91MP0002160_abnormal_reproductive_system1.02515251
92MP0000750_abnormal_muscle_regeneration1.00059333
93MP0004087_abnormal_muscle_fiber1.00016971
94MP0003111_abnormal_nucleus_morphology0.99560091
95MP0003385_abnormal_body_wall0.99431763
96MP0003632_abnormal_nervous_system0.99406216
97MP0000759_abnormal_skeletal_muscle0.98928472
98MP0005375_adipose_tissue_phenotype0.98130961
99MP0001849_ear_inflammation0.97093499
100MP0006035_abnormal_mitochondrial_morpho0.96718110
101MP0002909_abnormal_adrenal_gland0.96410505
102MP0005330_cardiomyopathy0.95774223
103MP0002106_abnormal_muscle_physiology0.95740552
104MP0003634_abnormal_glial_cell0.94518657
105MP0003950_abnormal_plasma_membrane0.94351895
106MP0004484_altered_response_of0.93129708
107MP0003941_abnormal_skin_development0.92973327
108MP0004085_abnormal_heartbeat0.92585852
109MP0002332_abnormal_exercise_endurance0.92387782
110MP0002060_abnormal_skin_morphology0.91292763
111MP0000013_abnormal_adipose_tissue0.88530410
112MP0005023_abnormal_wound_healing0.88424834
113MP0005451_abnormal_body_composition0.87796318
114MP0003861_abnormal_nervous_system0.87751944
115MP0005369_muscle_phenotype0.87469733
116MP0005385_cardiovascular_system_phenoty0.87330384
117MP0001544_abnormal_cardiovascular_syste0.87330384
118MP0005508_abnormal_skeleton_morphology0.84648832
119MP0001299_abnormal_eye_distance/0.84522402
120MP0003123_paternal_imprinting0.84378317
121MP0002295_abnormal_pulmonary_circulatio0.84254657
122MP0000920_abnormal_myelination0.80524004
123MP0002234_abnormal_pharynx_morphology0.80214451
124MP0001984_abnormal_olfaction0.79687258
125MP0003283_abnormal_digestive_organ0.79138548
126MP0005171_absent_coat_pigmentation0.78993612
127MP0003631_nervous_system_phenotype0.77987365
128MP0005666_abnormal_adipose_tissue0.77977877
129MP0008775_abnormal_heart_ventricle0.77781671
130MP0005253_abnormal_eye_physiology0.77757039
131MP0005595_abnormal_vascular_smooth0.75933953
132MP0001188_hyperpigmentation0.75520847
133MP0003122_maternal_imprinting0.75345705
134MP0002090_abnormal_vision0.74876681
135MP0009250_abnormal_appendicular_skeleto0.73480510
136MP0002653_abnormal_ependyma_morphology0.73261716
137MP0004133_heterotaxia0.73075469
138MP0003690_abnormal_glial_cell0.72003408
139MP0005187_abnormal_penis_morphology0.71552159
140MP0003045_fibrosis0.71233790
141MP0001879_abnormal_lymphatic_vessel0.71072544
142MP0003942_abnormal_urinary_system0.70236598
143MP0002089_abnormal_postnatal_growth/wei0.69883092
144MP0001502_abnormal_circadian_rhythm0.69594853
145MP0001177_atelectasis0.68927191
146MP0005499_abnormal_olfactory_system0.68236369
147MP0005394_taste/olfaction_phenotype0.68236369
148MP0000462_abnormal_digestive_system0.67126290
149MP0003718_maternal_effect0.66650939
150MP0005165_increased_susceptibility_to0.66396781
151MP0003119_abnormal_digestive_system0.64777757
152MP0003878_abnormal_ear_physiology0.64090449
153MP0005377_hearing/vestibular/ear_phenot0.64090449
154MP0002972_abnormal_cardiac_muscle0.63376970
155MP0008932_abnormal_embryonic_tissue0.62062432

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)5.92260409
2Type 1 muscle fiber predominance (HP:0003803)5.16118340
3Myokymia (HP:0002411)4.43752595
4Protrusio acetabuli (HP:0003179)4.21182298
5Focal motor seizures (HP:0011153)4.03919910
6Premature rupture of membranes (HP:0001788)4.03870964
7Fetal akinesia sequence (HP:0001989)3.91871827
8Neoplasm of the adrenal cortex (HP:0100641)3.67260059
9Focal seizures (HP:0007359)3.62452212
10Hyporeflexia of lower limbs (HP:0002600)3.44331277
11Increased variability in muscle fiber diameter (HP:0003557)3.37488904
12Congenital stationary night blindness (HP:0007642)3.31162073
13Increased connective tissue (HP:0009025)3.23952849
14Spinal rigidity (HP:0003306)3.22550034
15Abnormality of skeletal muscle fiber size (HP:0012084)3.18322274
16Progressive cerebellar ataxia (HP:0002073)3.14811798
17Visual hallucinations (HP:0002367)3.14220753
18Mildly elevated creatine phosphokinase (HP:0008180)3.08572137
19Stomach cancer (HP:0012126)3.05270434
20Absence seizures (HP:0002121)3.03384743
21Round ear (HP:0100830)3.02663788
22Epileptic encephalopathy (HP:0200134)3.01614059
23Progressive muscle weakness (HP:0003323)2.99056753
24External ophthalmoplegia (HP:0000544)2.97061099
25Cerebral hypomyelination (HP:0006808)2.96713996
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.94774961
27Ventricular fibrillation (HP:0001663)2.94705776
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.91554141
29Abnormality of the lower motor neuron (HP:0002366)2.88833580
30Distal lower limb muscle weakness (HP:0009053)2.88294022
31Exercise-induced muscle cramps (HP:0003710)2.88237761
32Ankle clonus (HP:0011448)2.87290115
33Shallow orbits (HP:0000586)2.86607472
34Action tremor (HP:0002345)2.86592003
35Atrophic scars (HP:0001075)2.82122829
36Lower limb amyotrophy (HP:0007210)2.77833900
37Distal lower limb amyotrophy (HP:0008944)2.77803147
38Atonic seizures (HP:0010819)2.77231038
39Amyotrophic lateral sclerosis (HP:0007354)2.74425048
40Dialeptic seizures (HP:0011146)2.71903001
41EMG: myopathic abnormalities (HP:0003458)2.71532647
42Vascular tortuosity (HP:0004948)2.69056962
43Broad-based gait (HP:0002136)2.66011873
44Aortic aneurysm (HP:0004942)2.65244692
45Breast hypoplasia (HP:0003187)2.65104969
46Supranuclear gaze palsy (HP:0000605)2.57808273
47Bladder diverticulum (HP:0000015)2.56569106
48Glioma (HP:0009733)2.55654235
49Myopathic facies (HP:0002058)2.55419117
50Arterial tortuosity (HP:0005116)2.55341667
51Aortic dissection (HP:0002647)2.53894367
52Generalized tonic-clonic seizures (HP:0002069)2.51840771
53Bundle branch block (HP:0011710)2.48959848
54Cerebral aneurysm (HP:0004944)2.48502408
55Muscle fiber splitting (HP:0003555)2.43924344
56Shoulder girdle muscle weakness (HP:0003547)2.43588142
57Febrile seizures (HP:0002373)2.42149503
58Neck muscle weakness (HP:0000467)2.41661883
59Distal arthrogryposis (HP:0005684)2.40593062
60Ankle contracture (HP:0006466)2.39736107
61Slender build (HP:0001533)2.37603774
62Asymmetric septal hypertrophy (HP:0001670)2.35753590
63Ventricular tachycardia (HP:0004756)2.34522644
64Fragile skin (HP:0001030)2.34288145
65Subaortic stenosis (HP:0001682)2.30994691
66Abnormality of the left ventricular outflow tract (HP:0011103)2.30994691
67Calcaneovalgus deformity (HP:0001848)2.30244946
68Difficulty running (HP:0009046)2.28581746
69Hyperacusis (HP:0010780)2.28400541
70Glucose intolerance (HP:0000833)2.27769681
71Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24547888
72Unsteady gait (HP:0002317)2.24309777
73Delusions (HP:0000746)2.24001023
74Scapular winging (HP:0003691)2.23312928
75Wormian bones (HP:0002645)2.22811624
76Sudden death (HP:0001699)2.22189603
77Difficulty climbing stairs (HP:0003551)2.22061597
78Hypoplastic nipples (HP:0002557)2.21591583
79Nemaline bodies (HP:0003798)2.20666874
80Muscle fiber inclusion bodies (HP:0100299)2.20332975
81Ulnar deviation of the wrist (HP:0003049)2.18555017
82Calf muscle hypertrophy (HP:0008981)2.18517666
83Aplasia/Hypoplasia of the earlobes (HP:0009906)2.17981680
84Distal upper limb amyotrophy (HP:0007149)2.17632522
85Upper limb amyotrophy (HP:0009129)2.17632522
86Abnormal atrioventricular conduction (HP:0005150)2.17464852
87Dysdiadochokinesis (HP:0002075)2.13864230
88Foot dorsiflexor weakness (HP:0009027)2.12525782
89Lipoatrophy (HP:0100578)2.12416971
90Deformed tarsal bones (HP:0008119)2.09960155
91Anxiety (HP:0000739)2.09017219
92Abnormality of the foot musculature (HP:0001436)2.08940080
93Broad metatarsal (HP:0001783)2.07977664
94Insomnia (HP:0100785)2.07277786
95Mutism (HP:0002300)2.06484496
96Neonatal short-limb short stature (HP:0008921)2.04907533
97Dysmetria (HP:0001310)2.04088028
98Myotonia (HP:0002486)2.02787056
99Abnormal eating behavior (HP:0100738)2.02703526
100Neurofibrillary tangles (HP:0002185)2.01641893
101Heart block (HP:0012722)2.01380039
102Overgrowth (HP:0001548)2.01322654
103Pheochromocytoma (HP:0002666)2.00738130
104Neoplasm of the adrenal gland (HP:0100631)1.99668443
105Mitral regurgitation (HP:0001653)1.99183746
106Genetic anticipation (HP:0003743)1.98740071
107Carpal bone hypoplasia (HP:0001498)1.98420378
108Urinary bladder sphincter dysfunction (HP:0002839)1.97921683
109Central scotoma (HP:0000603)1.97405929
110Achilles tendon contracture (HP:0001771)1.97332646
111Urinary urgency (HP:0000012)1.95877280
112Ulnar bowing (HP:0003031)1.95680190
113Poor eye contact (HP:0000817)1.95428476
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95275851
115EMG: neuropathic changes (HP:0003445)1.95008673
116Atrial fibrillation (HP:0005110)1.94366105
117Proximal tubulopathy (HP:0000114)1.93013220
118Bowel diverticulosis (HP:0005222)1.92932022
119Soft skin (HP:0000977)1.90476637
120Gaze-evoked nystagmus (HP:0000640)1.89488048
121Truncal ataxia (HP:0002078)1.88690136
122Exercise-induced myalgia (HP:0003738)1.88668901
123Cerebral inclusion bodies (HP:0100314)1.88259642
124Abnormality of the labia minora (HP:0012880)1.87605084
125Hammertoe (HP:0001765)1.87486289
126Abnormality of the calcaneus (HP:0008364)1.87245259
127CNS hypomyelination (HP:0003429)1.84639215
128Testicular atrophy (HP:0000029)1.83104312
129Right ventricular cardiomyopathy (HP:0011663)1.83063513
130Mitral valve prolapse (HP:0001634)1.82680350
131Atrioventricular block (HP:0001678)1.82281564
132Syncope (HP:0001279)1.82128869
133Abnormal social behavior (HP:0012433)1.81922932
134Impaired social interactions (HP:0000735)1.81922932
135Abnormality of the vocal cords (HP:0008777)1.81916654
136Abnormality of the calf musculature (HP:0001430)1.81106576
137Ulnar claw (HP:0001178)1.80746430
138Abnormal EKG (HP:0003115)1.80343883
139Hypoventilation (HP:0002791)1.78275201
140Athetosis (HP:0002305)1.77699213
141Follicular hyperkeratosis (HP:0007502)1.77154258
142Primary atrial arrhythmia (HP:0001692)1.76949773
143Abnormality of dentin (HP:0010299)1.76885038
144Myoglobinuria (HP:0002913)1.75451851
145Impaired vibration sensation in the lower limbs (HP:0002166)1.74579059
146Spastic gait (HP:0002064)1.74080905
147Decreased motor nerve conduction velocity (HP:0003431)1.73489525
148Termporal pattern (HP:0011008)1.72918942
149Insidious onset (HP:0003587)1.72918942
150Aneurysm (HP:0002617)1.72903673
151Turricephaly (HP:0000262)1.72804542
152Muscle stiffness (HP:0003552)1.72145131
153Polyphagia (HP:0002591)1.72090231
154Supraventricular arrhythmia (HP:0005115)1.71106552
155Hyperextensible skin (HP:0000974)1.71002912
156Horizontal nystagmus (HP:0000666)1.70843861
157Frequent falls (HP:0002359)1.70829331
158Obstructive sleep apnea (HP:0002870)1.70696619
159Supraventricular tachycardia (HP:0004755)1.70591320
160Abnormality of the Achilles tendon (HP:0005109)1.70041330
161Dilated cardiomyopathy (HP:0001644)1.69809831
162Hand muscle atrophy (HP:0009130)1.69650936
163Genu recurvatum (HP:0002816)1.68600621
164Thin ribs (HP:0000883)1.68334825
165Neuroendocrine neoplasm (HP:0100634)1.67313095
166Limb dystonia (HP:0002451)1.66966508
167Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65994725
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.64536558
169Muscle hypertrophy of the lower extremities (HP:0008968)1.64123112
170Prolonged QT interval (HP:0001657)1.62954909
171Epileptiform EEG discharges (HP:0011182)1.61144833
172Dysmetric saccades (HP:0000641)1.60881465
173Amblyopia (HP:0000646)1.60016519
174Rimmed vacuoles (HP:0003805)1.59922326
175Cortical visual impairment (HP:0100704)1.59750205
176Abnormality of pain sensation (HP:0010832)1.59278746
177Impaired pain sensation (HP:0007328)1.59278746
178EEG with generalized epileptiform discharges (HP:0011198)1.58597852
179Scotoma (HP:0000575)1.58423576
180Limb-girdle muscle weakness (HP:0003325)1.57947860
181Pointed chin (HP:0000307)1.57851818
182Distal sensory impairment (HP:0002936)1.57203001
183Depression (HP:0000716)1.56874842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.64608669
2PLK44.26391840
3ZAK3.87123123
4PNCK3.65185733
5IRAK23.16446648
6BUB12.96056982
7RIPK12.73990026
8PDGFRA2.58866641
9* MARK12.48741900
10MAP3K92.48725979
11MINK12.40688102
12TRIB32.27647219
13LATS22.26010867
14IRAK12.24062536
15NTRK32.09980259
16ICK2.05536584
17MYLK2.03909847
18NEK12.02863809
19EEF2K1.96903515
20EPHA21.86858810
21MAP3K41.82313659
22TTK1.71444087
23PTK21.70976701
24IRAK41.68316003
25DMPK1.66427141
26STK161.65690204
27TSSK61.64103303
28EPHA41.62456332
29DDR21.57583203
30PHKG11.42941906
31PHKG21.42941906
32PAK61.42206636
33STK381.42079128
34PLK21.41911782
35WEE11.39224927
36NME11.37299990
37SIK11.32696533
38PLK31.32005167
39CDK121.31571607
40PAK21.24969937
41NTRK11.24051838
42MOS1.19274244
43MET1.19072332
44PINK11.16313524
45NEK91.13249878
46CAMK2D1.09753886
47MAP3K121.07913043
48CDC42BPA1.07524799
49NTRK21.06955933
50CAMK2B1.06446164
51EPHB21.02630323
52MTOR1.01540560
53MAPK121.01259386
54MAP2K70.97871588
55EPHB10.97650011
56TESK20.96787135
57PRKCI0.95104440
58AKT30.93288060
59CAMK2G0.90922366
60ARAF0.90871925
61FGFR40.90112596
62PRKCG0.88839788
63LATS10.88796544
64MAP2K40.88416741
65MAP3K70.88175779
66LIMK10.86375738
67TRPM70.86165635
68ROCK20.83201535
69RPS6KA20.80380032
70LMTK20.80021794
71KSR20.78829366
72PRKD30.78639324
73CAMKK10.77186690
74STK38L0.75950729
75MAP3K60.74116746
76SGK30.73941328
77CDK140.72933938
78CAMK1G0.72246203
79KSR10.71811100
80PDGFRB0.71710672
81PDK40.71543154
82PDK30.71543154
83CDK50.69905016
84CAMK2A0.69321225
85SGK4940.68380269
86SGK2230.68380269
87CDK180.66368812
88PKN20.65376882
89CDK150.65186060
90MAP3K130.62858025
91MST1R0.62351516
92PAK40.62338903
93SMG10.61829606
94ERBB40.61807141
95GRK50.61669938
96PAK30.61015014
97CSNK1E0.59942756
98PRKD20.59010415
99DAPK20.58091523
100PIK3CG0.57496934
101PRKAA10.57376287
102CDK11A0.56354321
103PRKD10.56021485
104RET0.54755056
105CHEK20.54735242
106MUSK0.54330001
107MAPKAPK30.53666521
108PRKCH0.53137606
109OBSCN0.52624169
110MAPK70.52468295
111ALK0.52398352
112CAMKK20.52122323
113CASK0.51970669
114AKT20.51109525
115PLK10.50668616
116MAP2K10.50362681
117PDPK10.49585729
118PRKCZ0.47570156
119FER0.47262394
120TESK10.46276132
121SIK20.45601624
122PRPF4B0.45404344
123ABL20.45078407
124BCR0.44780193
125ROCK10.44662481
126DYRK20.44162615
127TYRO30.43928419
128PKN10.43157096
129UHMK10.42515001
130SGK20.42217899
131RPS6KA30.41572620
132ERN10.41514300
133MAPK130.40941269
134PRKG20.40318450
135PRKCE0.40168454
136AURKA0.39926167
137BRSK10.39396109
138WNK10.38942201
139TTN0.38723499
140DAPK10.38172547
141BRAF0.35522935
142SCYL20.35229246
143MARK20.32455168
144MAP3K110.32409609
145CAMK10.31802629
146CDK190.30117414
147PDK20.29390592
148SRPK10.27903129
149PAK10.27403901
150* MAPK100.27319523
151DYRK1A0.25003853
152FES0.22023725
153NEK60.21861191

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.46147784
2Nicotine addiction_Homo sapiens_hsa050333.44063964
3GABAergic synapse_Homo sapiens_hsa047272.38267764
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38116400
5Cardiac muscle contraction_Homo sapiens_hsa042602.29342346
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19185333
7Circadian entrainment_Homo sapiens_hsa047132.14575289
8Long-term potentiation_Homo sapiens_hsa047202.07778174
9Phototransduction_Homo sapiens_hsa047442.06104582
10Proteasome_Homo sapiens_hsa030502.06076584
11Glutamatergic synapse_Homo sapiens_hsa047242.00547603
12ECM-receptor interaction_Homo sapiens_hsa045121.98945714
13Oxidative phosphorylation_Homo sapiens_hsa001901.97526737
14Olfactory transduction_Homo sapiens_hsa047401.95890006
15Morphine addiction_Homo sapiens_hsa050321.87480832
16Amphetamine addiction_Homo sapiens_hsa050311.84055151
17Focal adhesion_Homo sapiens_hsa045101.82061316
18Parkinsons disease_Homo sapiens_hsa050121.79016181
19Oocyte meiosis_Homo sapiens_hsa041141.67001338
20Dopaminergic synapse_Homo sapiens_hsa047281.65841909
21Salivary secretion_Homo sapiens_hsa049701.63690971
22Collecting duct acid secretion_Homo sapiens_hsa049661.62917175
23Huntingtons disease_Homo sapiens_hsa050161.61661946
24Cholinergic synapse_Homo sapiens_hsa047251.61415244
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59155759
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59081043
27Oxytocin signaling pathway_Homo sapiens_hsa049211.51962376
28Insulin secretion_Homo sapiens_hsa049111.51400370
29Alzheimers disease_Homo sapiens_hsa050101.49265690
30Gastric acid secretion_Homo sapiens_hsa049711.47916302
31RNA polymerase_Homo sapiens_hsa030201.46272619
32Adherens junction_Homo sapiens_hsa045201.44801558
33Dilated cardiomyopathy_Homo sapiens_hsa054141.43305269
34Taste transduction_Homo sapiens_hsa047421.37926116
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36708319
36Calcium signaling pathway_Homo sapiens_hsa040201.33104647
37Long-term depression_Homo sapiens_hsa047301.30359449
38Gap junction_Homo sapiens_hsa045401.25936299
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24960280
40Serotonergic synapse_Homo sapiens_hsa047261.22430839
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22391108
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18352258
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17833563
44Renin secretion_Homo sapiens_hsa049241.17726906
45Axon guidance_Homo sapiens_hsa043601.17521937
46GnRH signaling pathway_Homo sapiens_hsa049121.16770822
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16027361
48Insulin signaling pathway_Homo sapiens_hsa049101.15233175
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.12288072
50Proteoglycans in cancer_Homo sapiens_hsa052051.08831709
51Vibrio cholerae infection_Homo sapiens_hsa051101.03885595
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03249006
53AMPK signaling pathway_Homo sapiens_hsa041521.01890125
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98466133
55Amoebiasis_Homo sapiens_hsa051460.98216256
56Protein digestion and absorption_Homo sapiens_hsa049740.94509782
57Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94362882
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94356697
59Estrogen signaling pathway_Homo sapiens_hsa049150.93759147
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91857068
61Tight junction_Homo sapiens_hsa045300.91264097
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89730466
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89147682
64Endometrial cancer_Homo sapiens_hsa052130.88765855
65Biosynthesis of amino acids_Homo sapiens_hsa012300.88057441
66Melanogenesis_Homo sapiens_hsa049160.86304868
67Cocaine addiction_Homo sapiens_hsa050300.85728863
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85350396
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84813427
70VEGF signaling pathway_Homo sapiens_hsa043700.84217486
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81227013
72Arginine and proline metabolism_Homo sapiens_hsa003300.80952919
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.79554825
74Carbon metabolism_Homo sapiens_hsa012000.77319232
75cAMP signaling pathway_Homo sapiens_hsa040240.77279579
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77212498
77Chronic myeloid leukemia_Homo sapiens_hsa052200.76161256
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75736448
79Bile secretion_Homo sapiens_hsa049760.74619113
80Pentose phosphate pathway_Homo sapiens_hsa000300.72699831
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72034999
82Arginine biosynthesis_Homo sapiens_hsa002200.71871539
83Glioma_Homo sapiens_hsa052140.71860125
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71365695
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71203618
86RNA transport_Homo sapiens_hsa030130.71103919
87ErbB signaling pathway_Homo sapiens_hsa040120.69783284
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68707814
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.67103923
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66390693
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66326564
92MicroRNAs in cancer_Homo sapiens_hsa052060.65666082
93Hedgehog signaling pathway_Homo sapiens_hsa043400.64551165
94Hippo signaling pathway_Homo sapiens_hsa043900.64522679
95Endocytosis_Homo sapiens_hsa041440.64212411
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63852239
97Fructose and mannose metabolism_Homo sapiens_hsa000510.61784800
98Renal cell carcinoma_Homo sapiens_hsa052110.61750978
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61513301
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61205868
101Bladder cancer_Homo sapiens_hsa052190.60838568
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60367067
103Purine metabolism_Homo sapiens_hsa002300.60335904
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60253835
105Lysine degradation_Homo sapiens_hsa003100.59289984
106Type II diabetes mellitus_Homo sapiens_hsa049300.59085496
107Inositol phosphate metabolism_Homo sapiens_hsa005620.57587893
108Insulin resistance_Homo sapiens_hsa049310.56595643
109Small cell lung cancer_Homo sapiens_hsa052220.55999138
110Choline metabolism in cancer_Homo sapiens_hsa052310.55847976
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55164239
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55137814
113MAPK signaling pathway_Homo sapiens_hsa040100.54624792
114Vitamin B6 metabolism_Homo sapiens_hsa007500.54565128
115mTOR signaling pathway_Homo sapiens_hsa041500.52354618
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51994404
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.50954795
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49565623
119Epstein-Barr virus infection_Homo sapiens_hsa051690.49219257
120Wnt signaling pathway_Homo sapiens_hsa043100.49116335
121Circadian rhythm_Homo sapiens_hsa047100.48718455
122Spliceosome_Homo sapiens_hsa030400.48213688
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48108330
124Pyrimidine metabolism_Homo sapiens_hsa002400.45624149
125Pancreatic secretion_Homo sapiens_hsa049720.45423527
126Ras signaling pathway_Homo sapiens_hsa040140.44922113
127Dorso-ventral axis formation_Homo sapiens_hsa043200.44261979
128Glucagon signaling pathway_Homo sapiens_hsa049220.43810322
129Prion diseases_Homo sapiens_hsa050200.43164906
130Fanconi anemia pathway_Homo sapiens_hsa034600.41589169
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.40180300
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.39925053
133Thyroid hormone synthesis_Homo sapiens_hsa049180.39042878
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38136435
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36904925
136Rap1 signaling pathway_Homo sapiens_hsa040150.36341176

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