

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.70567243 |
| 2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.40539195 |
| 3 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.31616357 |
| 4 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.31616357 |
| 5 | B cell receptor signaling pathway (GO:0050853) | 4.57410960 |
| 6 | ribosomal small subunit assembly (GO:0000028) | 4.47765166 |
| 7 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.45083291 |
| 8 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.22910638 |
| 9 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.20713944 |
| 10 | positive regulation of B cell differentiation (GO:0045579) | 4.14674631 |
| 11 | regulation of B cell differentiation (GO:0045577) | 4.04090094 |
| 12 | positive thymic T cell selection (GO:0045059) | 3.94188043 |
| 13 | regulation of gamma-delta T cell activation (GO:0046643) | 3.89472994 |
| 14 | negative thymic T cell selection (GO:0045060) | 3.80446142 |
| 15 | type I interferon signaling pathway (GO:0060337) | 3.79801321 |
| 16 | cellular response to type I interferon (GO:0071357) | 3.79801321 |
| 17 | viral transcription (GO:0019083) | 3.79520549 |
| 18 | response to type I interferon (GO:0034340) | 3.78799308 |
| 19 | negative T cell selection (GO:0043383) | 3.75741582 |
| 20 | detection of bacterium (GO:0016045) | 3.74530290 |
| 21 | positive regulation by symbiont of host defense response (GO:0052509) | 3.71838109 |
| 22 | modulation by symbiont of host defense response (GO:0052031) | 3.71838109 |
| 23 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.71838109 |
| 24 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.71838109 |
| 25 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.71838109 |
| 26 | modulation by symbiont of host immune response (GO:0052553) | 3.71838109 |
| 27 | translational termination (GO:0006415) | 3.62428695 |
| 28 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.61327706 |
| 29 | negative regulation of T cell mediated immunity (GO:0002710) | 3.59011594 |
| 30 | response to interleukin-15 (GO:0070672) | 3.58545588 |
| 31 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.56128155 |
| 32 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.51492662 |
| 33 | detection of other organism (GO:0098543) | 3.50926998 |
| 34 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.50405798 |
| 35 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.47124586 |
| 36 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.44819465 |
| 37 | cellular response to zinc ion (GO:0071294) | 3.41324069 |
| 38 | regulation of antigen processing and presentation (GO:0002577) | 3.37052193 |
| 39 | thymic T cell selection (GO:0045061) | 3.32377591 |
| 40 | DNA strand elongation (GO:0022616) | 3.29247741 |
| 41 | regulation of T cell tolerance induction (GO:0002664) | 3.28992919 |
| 42 | cellular response to interleukin-15 (GO:0071350) | 3.28363759 |
| 43 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.28067065 |
| 44 | Peyers patch development (GO:0048541) | 3.28067065 |
| 45 | ribosomal small subunit biogenesis (GO:0042274) | 3.27058173 |
| 46 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.25993386 |
| 47 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.25530420 |
| 48 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.24477932 |
| 49 | negative regulation of phagocytosis (GO:0050765) | 3.24233753 |
| 50 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.23339439 |
| 51 | translational elongation (GO:0006414) | 3.22427370 |
| 52 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.21536688 |
| 53 | germinal center formation (GO:0002467) | 3.20450483 |
| 54 | leukocyte aggregation (GO:0070486) | 3.18062623 |
| 55 | T cell homeostasis (GO:0043029) | 3.17229233 |
| 56 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.16079065 |
| 57 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.15462546 |
| 58 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.15462546 |
| 59 | telomere maintenance via recombination (GO:0000722) | 3.15300991 |
| 60 | NIK/NF-kappaB signaling (GO:0038061) | 3.15197310 |
| 61 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.14773688 |
| 62 | positive regulation of antigen processing and presentation (GO:0002579) | 3.14559544 |
| 63 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.14136776 |
| 64 | DNA unwinding involved in DNA replication (GO:0006268) | 3.13318672 |
| 65 | immunoglobulin mediated immune response (GO:0016064) | 3.12692453 |
| 66 | activated T cell proliferation (GO:0050798) | 3.12566440 |
| 67 | neutrophil activation involved in immune response (GO:0002283) | 3.10088337 |
| 68 | T cell selection (GO:0045058) | 3.09924114 |
| 69 | positive T cell selection (GO:0043368) | 3.08638625 |
| 70 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.06840063 |
| 71 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.05141254 |
| 72 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.03440399 |
| 73 | T cell migration (GO:0072678) | 3.03310437 |
| 74 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.03308705 |
| 75 | regulation of alpha-beta T cell activation (GO:0046634) | 2.99276359 |
| 76 | respiratory burst (GO:0045730) | 2.98766308 |
| 77 | maturation of SSU-rRNA (GO:0030490) | 2.96625603 |
| 78 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.94169756 |
| 79 | cotranslational protein targeting to membrane (GO:0006613) | 2.94168064 |
| 80 | protein targeting to ER (GO:0045047) | 2.93999269 |
| 81 | lymphocyte homeostasis (GO:0002260) | 2.93768144 |
| 82 | defense response to protozoan (GO:0042832) | 2.93286741 |
| 83 | mitotic recombination (GO:0006312) | 2.92972637 |
| 84 | macrophage activation involved in immune response (GO:0002281) | 2.92830060 |
| 85 | regulation of tolerance induction (GO:0002643) | 2.91197679 |
| 86 | cellular extravasation (GO:0045123) | 2.90962650 |
| 87 | cytidine metabolic process (GO:0046087) | 2.90388110 |
| 88 | cytidine catabolic process (GO:0006216) | 2.90388110 |
| 89 | cytidine deamination (GO:0009972) | 2.90388110 |
| 90 | response to muramyl dipeptide (GO:0032495) | 2.89458599 |
| 91 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.88743302 |
| 92 | myeloid cell activation involved in immune response (GO:0002275) | 2.87657503 |
| 93 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.87304548 |
| 94 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 2.85748262 |
| 95 | negative regulation of interleukin-12 production (GO:0032695) | 2.85321841 |
| 96 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.84704251 |
| 97 | translational initiation (GO:0006413) | 2.84429350 |
| 98 | negative regulation of innate immune response (GO:0045824) | 2.84169558 |
| 99 | mature B cell differentiation (GO:0002335) | 2.82536962 |
| 100 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.81953421 |
| 101 | viral life cycle (GO:0019058) | 2.80617804 |
| 102 | B cell mediated immunity (GO:0019724) | 2.80187660 |
| 103 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.79600549 |
| 104 | DNA deamination (GO:0045006) | 2.79125989 |
| 105 | cellular protein complex disassembly (GO:0043624) | 2.78924302 |
| 106 | mast cell activation (GO:0045576) | 2.78076457 |
| 107 | response to protozoan (GO:0001562) | 2.78031347 |
| 108 | DNA replication initiation (GO:0006270) | 2.75525777 |
| 109 | protein localization to endoplasmic reticulum (GO:0070972) | 2.74957694 |
| 110 | negative regulation of cell killing (GO:0031342) | 2.74499340 |
| 111 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.74499340 |
| 112 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.73799433 |
| 113 | negative regulation of B cell apoptotic process (GO:0002903) | 2.73439692 |
| 114 | T cell costimulation (GO:0031295) | 2.73414463 |
| 115 | tolerance induction (GO:0002507) | 2.72406964 |
| 116 | regulation of B cell apoptotic process (GO:0002902) | 2.70544276 |
| 117 | lymphocyte costimulation (GO:0031294) | 2.69226733 |
| 118 | interferon-gamma production (GO:0032609) | 2.66763266 |
| 119 | T cell receptor signaling pathway (GO:0050852) | 2.66556291 |
| 120 | negative regulation of B cell proliferation (GO:0030889) | 2.66040492 |
| 121 | telomere maintenance via telomere lengthening (GO:0010833) | 2.65536321 |
| 122 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.65404895 |
| 123 | positive regulation of interleukin-2 production (GO:0032743) | 2.64725341 |
| 124 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.62872499 |
| 125 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.62872499 |
| 126 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.61613837 |
| 127 | protein localization to kinetochore (GO:0034501) | 2.60490877 |
| 128 | B cell homeostasis (GO:0001782) | 2.60417075 |
| 129 | regulation of B cell proliferation (GO:0030888) | 2.60037964 |
| 130 | leukocyte homeostasis (GO:0001776) | 2.59527168 |
| 131 | myeloid dendritic cell activation (GO:0001773) | 2.58831035 |
| 132 | positive regulation of granulocyte differentiation (GO:0030854) | 2.57810937 |
| 133 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.57435413 |
| 134 | protein complex disassembly (GO:0043241) | 2.57423167 |
| 135 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 2.55208141 |
| 136 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.54889311 |
| 137 | formation of translation preinitiation complex (GO:0001731) | 2.53211320 |
| 138 | positive regulation of B cell activation (GO:0050871) | 2.50403764 |
| 139 | B cell proliferation (GO:0042100) | 2.49704183 |
| 140 | positive regulation of isotype switching (GO:0045830) | 2.49511706 |
| 141 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.49368318 |
| 142 | cellular response to interferon-beta (GO:0035458) | 2.48576863 |
| 143 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.47403297 |
| 144 | lymph node development (GO:0048535) | 2.46858826 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.13623888 |
| 2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.78544533 |
| 3 | MYC_22102868_ChIP-Seq_BL_Human | 3.45893908 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.15150250 |
| 5 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.13024724 |
| 6 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.87552285 |
| 7 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.87453995 |
| 8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.86110298 |
| 9 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.72355690 |
| 10 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.62248481 |
| 11 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.60276671 |
| 12 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.59939999 |
| 13 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.57545333 |
| 14 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.55408154 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.50454196 |
| 16 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.40343568 |
| 17 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.30098773 |
| 18 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.18527539 |
| 19 | MYB_26560356_Chip-Seq_TH2_Human | 2.13743032 |
| 20 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.08834581 |
| 21 | MAF_26560356_Chip-Seq_TH1_Human | 2.03697160 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.02879212 |
| 23 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.99504101 |
| 24 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.99354345 |
| 25 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.99297613 |
| 26 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.98825935 |
| 27 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.97943890 |
| 28 | MYB_26560356_Chip-Seq_TH1_Human | 1.97240442 |
| 29 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.92672788 |
| 30 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.91061471 |
| 31 | UTX_26944678_Chip-Seq_JUKART_Human | 1.86529164 |
| 32 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.84692598 |
| 33 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.80811215 |
| 34 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.78904138 |
| 35 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.77523789 |
| 36 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.75823638 |
| 37 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.74419707 |
| 38 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.72851178 |
| 39 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.71564343 |
| 40 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.71121425 |
| 41 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.70615935 |
| 42 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.70308692 |
| 43 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.67923587 |
| 44 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.67496780 |
| 45 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.65273113 |
| 46 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.65120420 |
| 47 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.64379413 |
| 48 | GATA3_26560356_Chip-Seq_TH2_Human | 1.63881017 |
| 49 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.63665179 |
| 50 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.63559811 |
| 51 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.59600034 |
| 52 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.58940577 |
| 53 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.58540935 |
| 54 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.54385568 |
| 55 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.53599665 |
| 56 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.52753624 |
| 57 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.50556623 |
| 58 | MAF_26560356_Chip-Seq_TH2_Human | 1.48960264 |
| 59 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.48853804 |
| 60 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.47393822 |
| 61 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.45361491 |
| 62 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.44144532 |
| 63 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.43210688 |
| 64 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.39033677 |
| 65 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.38969715 |
| 66 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.36880724 |
| 67 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.34047951 |
| 68 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.32896426 |
| 69 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31215082 |
| 70 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.31012379 |
| 71 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.30385045 |
| 72 | * NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.30366161 |
| 73 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.29924382 |
| 74 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.27182390 |
| 75 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.27056433 |
| 76 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.25998916 |
| 77 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.25235943 |
| 78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.23460290 |
| 79 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.22692873 |
| 80 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.22486345 |
| 81 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.21172989 |
| 82 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.17485625 |
| 83 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.16285966 |
| 84 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.15555084 |
| 85 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.14870668 |
| 86 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.14565586 |
| 87 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.13858574 |
| 88 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.13548008 |
| 89 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.13354944 |
| 90 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.13119734 |
| 91 | SPI1_23127762_ChIP-Seq_K562_Human | 1.12876724 |
| 92 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.12088069 |
| 93 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.11379973 |
| 94 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.10589349 |
| 95 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.10522401 |
| 96 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.06775524 |
| 97 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.06225801 |
| 98 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.05390425 |
| 99 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.05175280 |
| 100 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.04474001 |
| 101 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.04378360 |
| 102 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.03575304 |
| 103 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.03155692 |
| 104 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.02831058 |
| 105 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.02813105 |
| 106 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.02265658 |
| 107 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.02259237 |
| 108 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.02230230 |
| 109 | P300_27268052_Chip-Seq_Bcells_Human | 1.00601398 |
| 110 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.00051560 |
| 111 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.99362903 |
| 112 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.98115012 |
| 113 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.98035304 |
| 114 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.96238578 |
| 115 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.95539712 |
| 116 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.95105788 |
| 117 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.95000640 |
| 118 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.94704871 |
| 119 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.94421862 |
| 120 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.93551896 |
| 121 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.92436736 |
| 122 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.91335568 |
| 123 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.91101767 |
| 124 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.91056301 |
| 125 | GATA1_22025678_ChIP-Seq_K562_Human | 0.90829931 |
| 126 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.90824296 |
| 127 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.89627873 |
| 128 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.86989555 |
| 129 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.86196466 |
| 130 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.84082947 |
| 131 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.83492544 |
| 132 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.82419431 |
| 133 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.81575616 |
| 134 | GATA3_26560356_Chip-Seq_TH1_Human | 0.79217206 |
| 135 | P68_20966046_ChIP-Seq_HELA_Human | 0.78903545 |
| 136 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.78225153 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * MP0001835_abnormal_antigen_presentation | 4.35118622 |
| 2 | * MP0001800_abnormal_humoral_immune | 3.51130936 |
| 3 | MP0003763_abnormal_thymus_physiology | 3.45975834 |
| 4 | MP0000685_abnormal_immune_system | 3.38576445 |
| 5 | MP0005671_abnormal_response_to | 3.29575792 |
| 6 | MP0001790_abnormal_immune_system | 3.21978575 |
| 7 | MP0005387_immune_system_phenotype | 3.21978575 |
| 8 | MP0002396_abnormal_hematopoietic_system | 3.15684972 |
| 9 | * MP0002452_abnormal_antigen_presenting | 2.89950540 |
| 10 | * MP0002398_abnormal_bone_marrow | 2.82165744 |
| 11 | * MP0002420_abnormal_adaptive_immunity | 2.70682840 |
| 12 | * MP0002723_abnormal_immune_serum | 2.69772956 |
| 13 | * MP0001819_abnormal_immune_cell | 2.66746958 |
| 14 | MP0008057_abnormal_DNA_replication | 2.66032541 |
| 15 | * MP0005000_abnormal_immune_tolerance | 2.65642029 |
| 16 | * MP0000716_abnormal_immune_system | 2.43290077 |
| 17 | MP0000689_abnormal_spleen_morphology | 2.41509087 |
| 18 | MP0003693_abnormal_embryo_hatching | 2.39721532 |
| 19 | MP0010094_abnormal_chromosome_stability | 2.37016287 |
| 20 | MP0005025_abnormal_response_to | 2.34076279 |
| 21 | MP0002166_altered_tumor_susceptibility | 2.33791828 |
| 22 | MP0002722_abnormal_immune_system | 2.28854185 |
| 23 | MP0009785_altered_susceptibility_to | 2.27096632 |
| 24 | MP0003303_peritoneal_inflammation | 2.26155281 |
| 25 | MP0009333_abnormal_splenocyte_physiolog | 2.16992301 |
| 26 | MP0003436_decreased_susceptibility_to | 2.16155785 |
| 27 | * MP0002429_abnormal_blood_cell | 2.11979669 |
| 28 | MP0004808_abnormal_hematopoietic_stem | 2.09788880 |
| 29 | MP0000703_abnormal_thymus_morphology | 2.08902665 |
| 30 | MP0002405_respiratory_system_inflammati | 2.05804788 |
| 31 | MP0003077_abnormal_cell_cycle | 2.03750523 |
| 32 | MP0001873_stomach_inflammation | 1.99784168 |
| 33 | MP0003111_abnormal_nucleus_morphology | 1.94109766 |
| 34 | MP0002148_abnormal_hypersensitivity_rea | 1.93711655 |
| 35 | MP0002419_abnormal_innate_immunity | 1.93196793 |
| 36 | MP0001853_heart_inflammation | 1.91682422 |
| 37 | MP0002006_tumorigenesis | 1.86880358 |
| 38 | MP0010155_abnormal_intestine_physiology | 1.80482673 |
| 39 | MP0005464_abnormal_platelet_physiology | 1.80277527 |
| 40 | MP0002138_abnormal_hepatobiliary_system | 1.75273666 |
| 41 | MP0004957_abnormal_blastocyst_morpholog | 1.74278830 |
| 42 | MP0001545_abnormal_hematopoietic_system | 1.69957481 |
| 43 | MP0005397_hematopoietic_system_phenotyp | 1.69957481 |
| 44 | MP0000490_abnormal_crypts_of | 1.68863714 |
| 45 | MP0003866_abnormal_defecation | 1.61228568 |
| 46 | MP0008058_abnormal_DNA_repair | 1.55635040 |
| 47 | MP0001845_abnormal_inflammatory_respons | 1.55202103 |
| 48 | MP0003300_gastrointestinal_ulcer | 1.51150118 |
| 49 | MP0005174_abnormal_tail_pigmentation | 1.49599015 |
| 50 | MP0010352_gastrointestinal_tract_polyps | 1.48587820 |
| 51 | MP0002019_abnormal_tumor_incidence | 1.46421177 |
| 52 | MP0004947_skin_inflammation | 1.45823952 |
| 53 | MP0006082_CNS_inflammation | 1.36696341 |
| 54 | MP0000465_gastrointestinal_hemorrhage | 1.36202909 |
| 55 | MP0004510_myositis | 1.35307718 |
| 56 | MP0004381_abnormal_hair_follicle | 1.30081424 |
| 57 | MP0005075_abnormal_melanosome_morpholog | 1.27848376 |
| 58 | MP0008007_abnormal_cellular_replicative | 1.27711210 |
| 59 | MP0009278_abnormal_bone_marrow | 1.25537496 |
| 60 | MP0005310_abnormal_salivary_gland | 1.24283805 |
| 61 | MP0002933_joint_inflammation | 1.19922402 |
| 62 | MP0010307_abnormal_tumor_latency | 1.13103429 |
| 63 | MP0005645_abnormal_hypothalamus_physiol | 1.11318260 |
| 64 | MP0000858_altered_metastatic_potential | 1.07892025 |
| 65 | MP0000350_abnormal_cell_proliferation | 1.06501706 |
| 66 | MP0008469_abnormal_protein_level | 1.02358689 |
| 67 | MP0000313_abnormal_cell_death | 1.02329262 |
| 68 | MP0003724_increased_susceptibility_to | 0.98833371 |
| 69 | MP0002095_abnormal_skin_pigmentation | 0.96585298 |
| 70 | MP0006054_spinal_hemorrhage | 0.90537560 |
| 71 | MP0003786_premature_aging | 0.87387453 |
| 72 | MP0001730_embryonic_growth_arrest | 0.85656772 |
| 73 | MP0000015_abnormal_ear_pigmentation | 0.84975827 |
| 74 | MP0002132_abnormal_respiratory_system | 0.82084535 |
| 75 | MP0008260_abnormal_autophagy | 0.80690190 |
| 76 | MP0003448_altered_tumor_morphology | 0.80600898 |
| 77 | MP0002163_abnormal_gland_morphology | 0.79063691 |
| 78 | MP0002693_abnormal_pancreas_physiology | 0.77879477 |
| 79 | MP0001533_abnormal_skeleton_physiology | 0.72944271 |
| 80 | MP0001348_abnormal_lacrimal_gland | 0.71759517 |
| 81 | MP0005076_abnormal_cell_differentiation | 0.71621973 |
| 82 | MP0003045_fibrosis | 0.70418288 |
| 83 | MP0008961_abnormal_basal_metabolism | 0.68523339 |
| 84 | MP0005451_abnormal_body_composition | 0.66234710 |
| 85 | MP0002277_abnormal_respiratory_mucosa | 0.66068827 |
| 86 | MP0003172_abnormal_lysosome_physiology | 0.62841107 |
| 87 | MP0000477_abnormal_intestine_morphology | 0.62316822 |
| 88 | MP0002998_abnormal_bone_remodeling | 0.61938761 |
| 89 | MP0002928_abnormal_bile_duct | 0.61305737 |
| 90 | MP0002080_prenatal_lethality | 0.60946052 |
| 91 | MP0005166_decreased_susceptibility_to | 0.60748914 |
| 92 | MP0008877_abnormal_DNA_methylation | 0.60670905 |
| 93 | MP0003183_abnormal_peptide_metabolism | 0.59605129 |
| 94 | MP0000371_diluted_coat_color | 0.59028534 |
| 95 | MP0001663_abnormal_digestive_system | 0.58572301 |
| 96 | MP0005621_abnormal_cell_physiology | 0.58126588 |
| 97 | MP0008995_early_reproductive_senescence | 0.56650031 |
| 98 | MP0000372_irregular_coat_pigmentation | 0.56642457 |
| 99 | MP0008932_abnormal_embryonic_tissue | 0.55059986 |
| 100 | MP0002136_abnormal_kidney_physiology | 0.54714936 |
| 101 | MP0001986_abnormal_taste_sensitivity | 0.54281738 |
| 102 | MP0009765_abnormal_xenobiotic_induced | 0.54073361 |
| 103 | MP0002009_preneoplasia | 0.52833596 |
| 104 | MP0009763_increased_sensitivity_to | 0.51341532 |
| 105 | MP0003787_abnormal_imprinting | 0.51006886 |
| 106 | MP0001697_abnormal_embryo_size | 0.50583763 |
| 107 | MP0001851_eye_inflammation | 0.47805676 |
| 108 | MP0003984_embryonic_growth_retardation | 0.47560067 |
| 109 | MP0005023_abnormal_wound_healing | 0.47312846 |
| 110 | MP0000598_abnormal_liver_morphology | 0.47103135 |
| 111 | MP0003943_abnormal_hepatobiliary_system | 0.47082937 |
| 112 | MP0005384_cellular_phenotype | 0.46683568 |
| 113 | MP0006035_abnormal_mitochondrial_morpho | 0.46607176 |
| 114 | MP0008874_decreased_physiological_sensi | 0.46596382 |
| 115 | MP0005380_embryogenesis_phenotype | 0.46448094 |
| 116 | MP0001672_abnormal_embryogenesis/_devel | 0.46448094 |
| 117 | MP0002083_premature_death | 0.46375173 |
| 118 | MP0000249_abnormal_blood_vessel | 0.46155676 |
| 119 | MP0002086_abnormal_extraembryonic_tissu | 0.45592487 |
| 120 | MP0002088_abnormal_embryonic_growth/wei | 0.45335779 |
| 121 | MP0003191_abnormal_cellular_cholesterol | 0.45017606 |
| 122 | MP0003656_abnormal_erythrocyte_physiolo | 0.45008201 |
| 123 | MP0003806_abnormal_nucleotide_metabolis | 0.44870916 |
| 124 | MP0009764_decreased_sensitivity_to | 0.44790376 |
| 125 | MP0000609_abnormal_liver_physiology | 0.43998702 |
| 126 | MP0005381_digestive/alimentary_phenotyp | 0.43797571 |
| 127 | MP0006036_abnormal_mitochondrial_physio | 0.42615144 |
| 128 | MP0003252_abnormal_bile_duct | 0.42468605 |
| 129 | MP0008872_abnormal_physiological_respon | 0.41653727 |
| 130 | MP0009642_abnormal_blood_homeostasis | 0.39649184 |
| 131 | MP0005390_skeleton_phenotype | 0.37487847 |
| 132 | MP0003795_abnormal_bone_structure | 0.37307969 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Agammaglobulinemia (HP:0004432) | 5.44565565 |
| 2 | IgM deficiency (HP:0002850) | 5.30591149 |
| 3 | Recurrent bronchitis (HP:0002837) | 5.17924429 |
| 4 | Recurrent viral infections (HP:0004429) | 4.66279583 |
| 5 | Chronic otitis media (HP:0000389) | 4.51198578 |
| 6 | Panhypogammaglobulinemia (HP:0003139) | 4.45355014 |
| 7 | Cellulitis (HP:0100658) | 4.19933990 |
| 8 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.10537593 |
| 9 | Gastrointestinal stroma tumor (HP:0100723) | 4.02013103 |
| 10 | Recurrent fungal infections (HP:0002841) | 3.95679841 |
| 11 | Meningitis (HP:0001287) | 3.93258083 |
| 12 | Recurrent sinusitis (HP:0011108) | 3.87587463 |
| 13 | Recurrent abscess formation (HP:0002722) | 3.83923439 |
| 14 | Abnormality of T cells (HP:0002843) | 3.78441533 |
| 15 | T lymphocytopenia (HP:0005403) | 3.72894794 |
| 16 | Lymphopenia (HP:0001888) | 3.72843215 |
| 17 | Thrombocytosis (HP:0001894) | 3.68256332 |
| 18 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.67232805 |
| 19 | Inflammation of the large intestine (HP:0002037) | 3.65447213 |
| 20 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.64679836 |
| 21 | Gastrointestinal inflammation (HP:0004386) | 3.63858694 |
| 22 | Colitis (HP:0002583) | 3.63502602 |
| 23 | Abnormality of B cell number (HP:0010975) | 3.61311313 |
| 24 | B lymphocytopenia (HP:0010976) | 3.61311313 |
| 25 | Abnormality of T cell number (HP:0011839) | 3.60110655 |
| 26 | Abnormality of T cell physiology (HP:0011840) | 3.57381078 |
| 27 | Increased IgM level (HP:0003496) | 3.52799405 |
| 28 | IgG deficiency (HP:0004315) | 3.51075290 |
| 29 | Recurrent cutaneous fungal infections (HP:0011370) | 3.49159395 |
| 30 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.49159395 |
| 31 | Papilloma (HP:0012740) | 3.45341330 |
| 32 | Verrucae (HP:0200043) | 3.45341330 |
| 33 | Recurrent bacterial skin infections (HP:0005406) | 3.43132452 |
| 34 | Eczematoid dermatitis (HP:0000976) | 3.30152423 |
| 35 | Vasculitis (HP:0002633) | 3.22286899 |
| 36 | IgA deficiency (HP:0002720) | 3.19742489 |
| 37 | Orchitis (HP:0100796) | 3.19493507 |
| 38 | Nasal polyposis (HP:0100582) | 3.18743643 |
| 39 | Thyroiditis (HP:0100646) | 3.16804245 |
| 40 | Abnormality of the fingertips (HP:0001211) | 3.12518618 |
| 41 | Gastrointestinal infarctions (HP:0005244) | 3.12153782 |
| 42 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.11730315 |
| 43 | Lymphoma (HP:0002665) | 3.09018661 |
| 44 | Chronic sinusitis (HP:0011109) | 3.08925610 |
| 45 | Abnormal number of erythroid precursors (HP:0012131) | 3.08647611 |
| 46 | Myositis (HP:0100614) | 2.94997066 |
| 47 | Combined immunodeficiency (HP:0005387) | 2.94949426 |
| 48 | Bronchitis (HP:0012387) | 2.91860597 |
| 49 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.91724299 |
| 50 | Mediastinal lymphadenopathy (HP:0100721) | 2.91055658 |
| 51 | Emphysema (HP:0002097) | 2.90662362 |
| 52 | Reticulocytopenia (HP:0001896) | 2.90212131 |
| 53 | Severe combined immunodeficiency (HP:0004430) | 2.89802500 |
| 54 | Recurrent skin infections (HP:0001581) | 2.88977506 |
| 55 | Chronic obstructive pulmonary disease (HP:0006510) | 2.80764616 |
| 56 | Obstructive lung disease (HP:0006536) | 2.80764616 |
| 57 | Urticaria (HP:0001025) | 2.80721336 |
| 58 | Pustule (HP:0200039) | 2.79379055 |
| 59 | Abnormality of the nasal mucosa (HP:0000433) | 2.70793114 |
| 60 | Recurrent lower respiratory tract infections (HP:0002783) | 2.63707255 |
| 61 | Autoimmune thrombocytopenia (HP:0001973) | 2.63584893 |
| 62 | Osteomyelitis (HP:0002754) | 2.62505849 |
| 63 | Petechiae (HP:0000967) | 2.60655783 |
| 64 | Recurrent pneumonia (HP:0006532) | 2.60438796 |
| 65 | Encephalitis (HP:0002383) | 2.51046847 |
| 66 | Basal cell carcinoma (HP:0002671) | 2.50828399 |
| 67 | Abnormality of the pleura (HP:0002103) | 2.47256138 |
| 68 | Keratoconjunctivitis sicca (HP:0001097) | 2.45301089 |
| 69 | Leukopenia (HP:0001882) | 2.41031445 |
| 70 | Recurrent otitis media (HP:0000403) | 2.40918742 |
| 71 | Granulocytopenia (HP:0001913) | 2.40554231 |
| 72 | Keratoconjunctivitis (HP:0001096) | 2.39473085 |
| 73 | Eosinophilia (HP:0001880) | 2.34937703 |
| 74 | Prolonged bleeding time (HP:0003010) | 2.32186784 |
| 75 | Increased IgE level (HP:0003212) | 2.30937203 |
| 76 | Viral hepatitis (HP:0006562) | 2.29570348 |
| 77 | Restrictive lung disease (HP:0002091) | 2.29172323 |
| 78 | Chronic diarrhea (HP:0002028) | 2.27785208 |
| 79 | Sepsis (HP:0100806) | 2.25500721 |
| 80 | Abnormality of eosinophils (HP:0001879) | 2.24655564 |
| 81 | Spontaneous hematomas (HP:0007420) | 2.21982885 |
| 82 | Aplastic anemia (HP:0001915) | 2.20334236 |
| 83 | Skin rash (HP:0000988) | 2.19834316 |
| 84 | Poikiloderma (HP:0001029) | 2.19794540 |
| 85 | Leukocytosis (HP:0001974) | 2.17591048 |
| 86 | Acute hepatic failure (HP:0006554) | 2.17563550 |
| 87 | Skin ulcer (HP:0200042) | 2.17312495 |
| 88 | Interstitial pulmonary disease (HP:0006530) | 2.15823637 |
| 89 | Pulmonary embolism (HP:0002204) | 2.15547779 |
| 90 | Pallor (HP:0000980) | 2.13648272 |
| 91 | Stomatitis (HP:0010280) | 2.09706598 |
| 92 | Amaurosis fugax (HP:0100576) | 2.09056893 |
| 93 | Abnormality of male internal genitalia (HP:0000022) | 2.08819463 |
| 94 | Neutropenia (HP:0001875) | 2.07412510 |
| 95 | Myelodysplasia (HP:0002863) | 2.07051830 |
| 96 | Arterial thrombosis (HP:0004420) | 2.06232368 |
| 97 | Papilledema (HP:0001085) | 2.03415692 |
| 98 | Pulmonary infiltrates (HP:0002113) | 2.01083799 |
| 99 | Arthralgia (HP:0002829) | 2.00179553 |
| 100 | Gingivitis (HP:0000230) | 1.98677849 |
| 101 | Hypoplasia of the thymus (HP:0000778) | 1.96194230 |
| 102 | Joint swelling (HP:0001386) | 1.96092312 |
| 103 | Gangrene (HP:0100758) | 1.96077364 |
| 104 | Birth length less than 3rd percentile (HP:0003561) | 1.95799282 |
| 105 | Abnormality of macrophages (HP:0004311) | 1.94591496 |
| 106 | Chest pain (HP:0100749) | 1.92755563 |
| 107 | Epistaxis (HP:0000421) | 1.90366424 |
| 108 | Abnormality of the prostate (HP:0008775) | 1.90359256 |
| 109 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.90240828 |
| 110 | Hemoptysis (HP:0002105) | 1.88709932 |
| 111 | Hypergammaglobulinemia (HP:0010702) | 1.88392219 |
| 112 | Optic neuritis (HP:0100653) | 1.85969824 |
| 113 | Retrobulbar optic neuritis (HP:0100654) | 1.85969824 |
| 114 | Pulmonary fibrosis (HP:0002206) | 1.85276107 |
| 115 | Autoimmune hemolytic anemia (HP:0001890) | 1.80034213 |
| 116 | Abnormal platelet volume (HP:0011876) | 1.77061403 |
| 117 | Hypochromic anemia (HP:0001931) | 1.76963284 |
| 118 | Fatigue (HP:0012378) | 1.76077348 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * MAP4K1 | 4.82750043 |
| 2 | EEF2K | 2.75172231 |
| 3 | PRPF4B | 2.72224478 |
| 4 | BLK | 2.60765097 |
| 5 | MAP3K10 | 2.52036150 |
| 6 | BTK | 2.40529157 |
| 7 | GRK6 | 2.36436672 |
| 8 | TXK | 2.30932905 |
| 9 | JAK3 | 2.30047475 |
| 10 | STK10 | 2.28980165 |
| 11 | TYK2 | 2.22562781 |
| 12 | ZAP70 | 2.20019838 |
| 13 | KIT | 2.14268070 |
| 14 | * SYK | 2.01443508 |
| 15 | CDC7 | 1.81740416 |
| 16 | TEC | 1.76902240 |
| 17 | IKBKE | 1.76252759 |
| 18 | NME2 | 1.75484224 |
| 19 | LRRK2 | 1.71437906 |
| 20 | MAP3K14 | 1.70455435 |
| 21 | IRAK4 | 1.67227070 |
| 22 | TBK1 | 1.63280163 |
| 23 | ERN1 | 1.61385952 |
| 24 | NEK2 | 1.61196664 |
| 25 | ITK | 1.54502494 |
| 26 | TESK2 | 1.46620664 |
| 27 | PIM1 | 1.44131540 |
| 28 | IKBKB | 1.40872508 |
| 29 | LCK | 1.37816387 |
| 30 | BUB1 | 1.34686788 |
| 31 | SMG1 | 1.33029267 |
| 32 | CLK1 | 1.31928004 |
| 33 | JAK1 | 1.31204833 |
| 34 | RPS6KA4 | 1.28380594 |
| 35 | WEE1 | 1.25458719 |
| 36 | HCK | 1.23273977 |
| 37 | * LYN | 1.21855644 |
| 38 | FLT3 | 1.21739362 |
| 39 | EIF2AK1 | 1.21118548 |
| 40 | CDK12 | 1.19396620 |
| 41 | FGFR4 | 1.18370826 |
| 42 | MAP2K3 | 1.18084203 |
| 43 | CDK4 | 1.16785118 |
| 44 | PKN2 | 1.16076943 |
| 45 | CSK | 1.12935189 |
| 46 | SIK2 | 1.12806476 |
| 47 | EIF2AK3 | 1.12326788 |
| 48 | MAP3K13 | 1.10615310 |
| 49 | CDK19 | 1.08616434 |
| 50 | BMPR2 | 1.01312228 |
| 51 | MST4 | 1.00299632 |
| 52 | PIM2 | 1.00087154 |
| 53 | IRAK3 | 0.99576902 |
| 54 | RPS6KB2 | 0.99368832 |
| 55 | SCYL2 | 0.97705157 |
| 56 | * CSF1R | 0.96602392 |
| 57 | ATR | 0.96490083 |
| 58 | KDR | 0.96277088 |
| 59 | RIPK4 | 0.96174640 |
| 60 | FES | 0.95044807 |
| 61 | FGFR3 | 0.94197600 |
| 62 | STK4 | 0.93006940 |
| 63 | CHUK | 0.83543067 |
| 64 | ACVR1B | 0.82973227 |
| 65 | TRIB3 | 0.81674623 |
| 66 | MARK3 | 0.81451240 |
| 67 | MAP3K8 | 0.80065873 |
| 68 | MAPK12 | 0.79561276 |
| 69 | NLK | 0.77755319 |
| 70 | SIK3 | 0.77022865 |
| 71 | TNK2 | 0.76736671 |
| 72 | PASK | 0.75203880 |
| 73 | CDK7 | 0.70677214 |
| 74 | TGFBR1 | 0.69809915 |
| 75 | PIK3CG | 0.68950038 |
| 76 | FGR | 0.67363426 |
| 77 | ALK | 0.67033879 |
| 78 | PRKCQ | 0.65949938 |
| 79 | BRD4 | 0.65414536 |
| 80 | VRK1 | 0.64440768 |
| 81 | CAMKK1 | 0.63883852 |
| 82 | MAPK7 | 0.61780240 |
| 83 | MAPK11 | 0.59388392 |
| 84 | AURKB | 0.58739947 |
| 85 | DYRK3 | 0.58467038 |
| 86 | TSSK6 | 0.58043833 |
| 87 | TLK1 | 0.57417028 |
| 88 | MAP3K7 | 0.55190063 |
| 89 | IRAK1 | 0.53921445 |
| 90 | MATK | 0.53284863 |
| 91 | TAOK3 | 0.53208877 |
| 92 | HIPK2 | 0.52091994 |
| 93 | PRKD2 | 0.51784643 |
| 94 | CHEK1 | 0.51768861 |
| 95 | BCKDK | 0.51327583 |
| 96 | SRPK1 | 0.49207693 |
| 97 | FYN | 0.49079426 |
| 98 | * PDK1 | 0.48204929 |
| 99 | JAK2 | 0.48200518 |
| 100 | TAOK1 | 0.47313906 |
| 101 | TGFBR2 | 0.46616051 |
| 102 | PRKCH | 0.46582232 |
| 103 | MAP3K11 | 0.46458797 |
| 104 | CDC42BPA | 0.46393735 |
| 105 | EPHB1 | 0.44921033 |
| 106 | NEK9 | 0.44254175 |
| 107 | CDK6 | 0.44235761 |
| 108 | MAPK4 | 0.42679204 |
| 109 | BRSK2 | 0.42654094 |
| 110 | MAP3K1 | 0.42625412 |
| 111 | RPS6KA6 | 0.42585338 |
| 112 | TAOK2 | 0.42348812 |
| 113 | MAP2K2 | 0.41779913 |
| 114 | PLK1 | 0.41089339 |
| 115 | CCNB1 | 0.40449216 |
| 116 | CAMKK2 | 0.39629795 |
| 117 | MARK2 | 0.37061514 |
| 118 | MAPKAPK2 | 0.36559351 |
| 119 | ZAK | 0.36002309 |
| 120 | MAP2K6 | 0.34853207 |
| 121 | MELK | 0.34308132 |
| 122 | BRSK1 | 0.33752459 |
| 123 | RPS6KA5 | 0.32710531 |
| 124 | * CDK2 | 0.32646032 |
| 125 | RPS6KL1 | 0.30739736 |
| 126 | RPS6KC1 | 0.30739736 |
| 127 | MAPK3 | 0.30234155 |
| 128 | CDK9 | 0.29799945 |
| 129 | ATM | 0.29350256 |
| 130 | PDPK1 | 0.28787033 |
| 131 | VRK2 | 0.28773228 |
| 132 | STK11 | 0.24730063 |
| 133 | * ABL1 | 0.23876281 |
| 134 | PRKCD | 0.23233111 |
| 135 | MAP3K5 | 0.22486290 |
| 136 | NUAK1 | 0.18997783 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.65100329 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.73413327 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.03194590 |
| 4 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.92265194 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 2.83083999 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 2.72454138 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.26074250 |
| 8 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.24773660 |
| 9 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.23296630 |
| 10 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.20964489 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.06133262 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.00633484 |
| 13 | Measles_Homo sapiens_hsa05162 | 1.94404761 |
| 14 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.93359995 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.88209550 |
| 16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.83931872 |
| 17 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.78898392 |
| 18 | Leishmaniasis_Homo sapiens_hsa05140 | 1.78847171 |
| 19 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.78066847 |
| 20 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.77071089 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.76379578 |
| 22 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.69796689 |
| 23 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.61170361 |
| 24 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.54056912 |
| 25 | Cell cycle_Homo sapiens_hsa04110 | 1.45673173 |
| 26 | RNA transport_Homo sapiens_hsa03013 | 1.43235794 |
| 27 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.41640395 |
| 28 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.38775404 |
| 29 | RNA polymerase_Homo sapiens_hsa03020 | 1.36603455 |
| 30 | Proteasome_Homo sapiens_hsa03050 | 1.35981004 |
| 31 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.35707830 |
| 32 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.35276056 |
| 33 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.34604012 |
| 34 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.30962876 |
| 35 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.29814126 |
| 36 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.28603414 |
| 37 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.25837770 |
| 38 | Allograft rejection_Homo sapiens_hsa05330 | 1.23400020 |
| 39 | RNA degradation_Homo sapiens_hsa03018 | 1.15976111 |
| 40 | Hepatitis B_Homo sapiens_hsa05161 | 1.15928262 |
| 41 | Shigellosis_Homo sapiens_hsa05131 | 1.15742705 |
| 42 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.14069228 |
| 43 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.10808085 |
| 44 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.10537898 |
| 45 | Influenza A_Homo sapiens_hsa05164 | 1.10456177 |
| 46 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.09554483 |
| 47 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.09068880 |
| 48 | Apoptosis_Homo sapiens_hsa04210 | 1.06989223 |
| 49 | Legionellosis_Homo sapiens_hsa05134 | 1.04678734 |
| 50 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.03713124 |
| 51 | Viral myocarditis_Homo sapiens_hsa05416 | 1.01340785 |
| 52 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.99966342 |
| 53 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.98818958 |
| 54 | HTLV-I infection_Homo sapiens_hsa05166 | 0.96631901 |
| 55 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.94219421 |
| 56 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.92479758 |
| 57 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.91974793 |
| 58 | Tuberculosis_Homo sapiens_hsa05152 | 0.90253247 |
| 59 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.89314446 |
| 60 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.88515847 |
| 61 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.87310487 |
| 62 | Asthma_Homo sapiens_hsa05310 | 0.76761500 |
| 63 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.76735500 |
| 64 | Platelet activation_Homo sapiens_hsa04611 | 0.76719221 |
| 65 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.70848911 |
| 66 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.70122359 |
| 67 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.69636794 |
| 68 | Pertussis_Homo sapiens_hsa05133 | 0.65579022 |
| 69 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.65188232 |
| 70 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.65099443 |
| 71 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.64633400 |
| 72 | Phagosome_Homo sapiens_hsa04145 | 0.64239923 |
| 73 | Basal transcription factors_Homo sapiens_hsa03022 | 0.64137349 |
| 74 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.63645615 |
| 75 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.59584544 |
| 76 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.58761415 |
| 77 | Malaria_Homo sapiens_hsa05144 | 0.56511624 |
| 78 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.56346402 |
| 79 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.55651727 |
| 80 | Hepatitis C_Homo sapiens_hsa05160 | 0.55071037 |
| 81 | Other glycan degradation_Homo sapiens_hsa00511 | 0.50904999 |
| 82 | Colorectal cancer_Homo sapiens_hsa05210 | 0.50773696 |
| 83 | Purine metabolism_Homo sapiens_hsa00230 | 0.49600049 |
| 84 | Salmonella infection_Homo sapiens_hsa05132 | 0.49167556 |
| 85 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.47458884 |
| 86 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.47239011 |
| 87 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.45883266 |
| 88 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.45422319 |
| 89 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.42640160 |
| 90 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.42552466 |
| 91 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.37980913 |
| 92 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.37754404 |
| 93 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.36874337 |
| 94 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.34904889 |
| 95 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.33622128 |
| 96 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.32425723 |
| 97 | Sulfur relay system_Homo sapiens_hsa04122 | 0.29214613 |
| 98 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.28785758 |
| 99 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.27150439 |
| 100 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.26855457 |
| 101 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.26797197 |
| 102 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.24893914 |
| 103 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.23722572 |
| 104 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.23027033 |
| 105 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.22693687 |
| 106 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.22590222 |
| 107 | Alcoholism_Homo sapiens_hsa05034 | 0.22551818 |
| 108 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.21512347 |
| 109 | Thyroid cancer_Homo sapiens_hsa05216 | 0.20504279 |
| 110 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.19922409 |
| 111 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.18930372 |
| 112 | * MAPK signaling pathway_Homo sapiens_hsa04010 | 0.18029963 |
| 113 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.17599977 |
| 114 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.17263698 |
| 115 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.15673384 |
| 116 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.15448582 |
| 117 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.13760384 |
| 118 | Endocytosis_Homo sapiens_hsa04144 | 0.12812058 |
| 119 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.12397415 |
| 120 | Prostate cancer_Homo sapiens_hsa05215 | 0.11969509 |
| 121 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.11653589 |
| 122 | Insulin resistance_Homo sapiens_hsa04931 | 0.11131757 |
| 123 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.07463730 |
| 124 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.06658138 |
| 125 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.05626530 |

