MAP4K2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.65910236
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.60246890
3negative regulation of cell killing (GO:0031342)6.60246890
4regulation of gamma-delta T cell differentiation (GO:0045586)6.60219129
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.07620704
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.07620704
7regulation of gamma-delta T cell activation (GO:0046643)5.97158582
8antigen processing and presentation of endogenous antigen (GO:0019883)5.94703368
9positive thymic T cell selection (GO:0045059)5.91599413
10B cell receptor signaling pathway (GO:0050853)5.59393888
11negative T cell selection (GO:0043383)5.49273494
12negative thymic T cell selection (GO:0045060)5.42816104
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.35524654
14positive T cell selection (GO:0043368)5.24222852
15thymic T cell selection (GO:0045061)5.15023286
16response to interleukin-15 (GO:0070672)5.13399005
17T cell selection (GO:0045058)5.11523450
18regulation of regulatory T cell differentiation (GO:0045589)4.89483851
19regulation of B cell receptor signaling pathway (GO:0050855)4.75855221
20regulation of B cell differentiation (GO:0045577)4.52776379
21neutrophil activation involved in immune response (GO:0002283)4.45155759
22cellular response to interleukin-15 (GO:0071350)4.42680834
23positive regulation of B cell differentiation (GO:0045579)4.40309825
24leukocyte aggregation (GO:0070486)4.35888008
25antigen receptor-mediated signaling pathway (GO:0050851)4.30600305
26tolerance induction (GO:0002507)4.23234443
27positive regulation of Rap GTPase activity (GO:0032854)4.11853131
28T cell migration (GO:0072678)4.09590445
29positive regulation by symbiont of host defense response (GO:0052509)4.08843322
30modulation by symbiont of host defense response (GO:0052031)4.08843322
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.08843322
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.08843322
33positive regulation by organism of defense response of other organism involved in symbiotic interact4.08843322
34modulation by symbiont of host immune response (GO:0052553)4.08843322
35T cell receptor signaling pathway (GO:0050852)4.06407691
36regulation of T cell tolerance induction (GO:0002664)3.92744288
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.88680900
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.86002887
39positive regulation of histone deacetylation (GO:0031065)3.82756738
40T cell costimulation (GO:0031295)3.79776861
41T cell homeostasis (GO:0043029)3.79604694
42regulation of isotype switching to IgG isotypes (GO:0048302)3.75674476
43lymphocyte costimulation (GO:0031294)3.72547851
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.63405893
45neutrophil activation (GO:0042119)3.60715779
46positive regulation of tolerance induction (GO:0002645)3.60261571
47interferon-gamma production (GO:0032609)3.56533338
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.54265376
49positive regulation of interleukin-2 production (GO:0032743)3.53537861
50detection of bacterium (GO:0016045)3.45090639
51regulation of alpha-beta T cell proliferation (GO:0046640)3.43611657
52histone H3-K4 trimethylation (GO:0080182)3.41690299
53regulation of Rap GTPase activity (GO:0032317)3.41485430
54detection of other organism (GO:0098543)3.41332617
55mast cell degranulation (GO:0043303)3.41102826
56mast cell activation involved in immune response (GO:0002279)3.41102826
57immunoglobulin mediated immune response (GO:0016064)3.40649661
58positive regulation of granulocyte differentiation (GO:0030854)3.40058734
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39364591
60natural killer cell differentiation (GO:0001779)3.39170709
61germinal center formation (GO:0002467)3.37662083
62immune response-activating cell surface receptor signaling pathway (GO:0002429)3.37660110
63negative regulation of erythrocyte differentiation (GO:0045647)3.37209300
64lymphocyte homeostasis (GO:0002260)3.33861094
65response to muramyl dipeptide (GO:0032495)3.32935954
66regulation of mast cell degranulation (GO:0043304)3.30957648
67negative regulation of T cell mediated immunity (GO:0002710)3.28139849
68leukocyte degranulation (GO:0043299)3.26646697
69macrophage activation involved in immune response (GO:0002281)3.24406594
70negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.21816039
71negative regulation of T-helper cell differentiation (GO:0045623)3.21816039
72myeloid cell activation involved in immune response (GO:0002275)3.21355746
73mast cell activation (GO:0045576)3.21335415
74activated T cell proliferation (GO:0050798)3.20933294
75B cell proliferation (GO:0042100)3.18736470
76granulocyte activation (GO:0036230)3.17901192
77positive regulation of mast cell activation (GO:0033005)3.15887718
78mature B cell differentiation (GO:0002335)3.13063220
79defense response to protozoan (GO:0042832)3.12862303
80regulation of mast cell activation involved in immune response (GO:0033006)3.12739023
81response to peptidoglycan (GO:0032494)3.12627874
82negative regulation of lymphocyte mediated immunity (GO:0002707)3.11727082
83adaptation of signaling pathway (GO:0023058)3.11517843
84regulation of interleukin-2 biosynthetic process (GO:0045076)3.10145754
85mucosal-associated lymphoid tissue development (GO:0048537)3.08796558
86Peyers patch development (GO:0048541)3.08796558
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.08348088
88regulation of mast cell activation (GO:0033003)3.07885454
89regulation of tolerance induction (GO:0002643)3.06620823
90positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04255773
91negative regulation of interleukin-12 production (GO:0032695)3.02196555
92regulation of T cell receptor signaling pathway (GO:0050856)3.01590385
93regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01508299
94negative regulation of phagocytosis (GO:0050765)2.99302806
95leukocyte homeostasis (GO:0001776)2.96598163
96megakaryocyte development (GO:0035855)2.93498566
97regulation of leukocyte degranulation (GO:0043300)2.88424138
98response to type I interferon (GO:0034340)2.88253112
99B cell homeostasis (GO:0001782)2.87776887
100response to protozoan (GO:0001562)2.87406197
101regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.85865000
102regulation of natural killer cell mediated immunity (GO:0002715)2.85865000
103leukocyte cell-cell adhesion (GO:0007159)2.84863951
104cellular response to type I interferon (GO:0071357)2.84296218
105type I interferon signaling pathway (GO:0060337)2.84296218
106regulation of interleukin-2 production (GO:0032663)2.83624881
107cellular extravasation (GO:0045123)2.83288979
108lymph node development (GO:0048535)2.82345396
109positive regulation of protein deacetylation (GO:0090312)2.81905589
110antigen processing and presentation via MHC class Ib (GO:0002475)2.81693694
111interferon-gamma-mediated signaling pathway (GO:0060333)2.81584958
112NIK/NF-kappaB signaling (GO:0038061)2.81446777
113regulation of interferon-beta biosynthetic process (GO:0045357)2.80904055
114histone H3-K4 methylation (GO:0051568)2.80600881
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79214149
116response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79066236
117response to host immune response (GO:0052572)2.79066236
118regulation of T cell mediated cytotoxicity (GO:0001914)2.78665265
119V(D)J recombination (GO:0033151)2.78151285
120regulation of ARF protein signal transduction (GO:0032012)2.77600246
121positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.77137239
122regulation of MHC class II biosynthetic process (GO:0045346)2.76449383
123negative regulation of innate immune response (GO:0045824)2.75785184
124negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.75410953
125negative regulation of type I interferon production (GO:0032480)2.74464672
126cellular response to zinc ion (GO:0071294)2.73025308
127interkinetic nuclear migration (GO:0022027)2.72164648
128regulation of granulocyte differentiation (GO:0030852)2.71196575
129regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.71142078
130mononuclear cell proliferation (GO:0032943)2.67559640
131positive regulation of isotype switching (GO:0045830)2.66941652
132T cell proliferation (GO:0042098)2.66629703
133regulation of B cell proliferation (GO:0030888)2.65235397
134negative regulation of bone resorption (GO:0045779)2.65166895
135negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.65063374
136positive regulation of immunoglobulin production (GO:0002639)2.65014288
137negative regulation of leukocyte mediated immunity (GO:0002704)2.64775865
138regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63707920
139lymphocyte proliferation (GO:0046651)2.63130375
140positive regulation of T cell differentiation (GO:0045582)2.63073490
141natural killer cell activation (GO:0030101)2.62721209
142positive regulation of gene expression, epigenetic (GO:0045815)2.62037067
143regulation of alpha-beta T cell activation (GO:0046634)2.61442699
144negative regulation of histone methylation (GO:0031061)2.60958684
145positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60081493
146regulation of histone H3-K27 methylation (GO:0061085)2.59142774
147positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57382800
148regulation of isotype switching (GO:0045191)2.56872840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.36059201
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.14929379
3MYC_22102868_ChIP-Seq_BL_Human4.59371773
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.13594849
5RUNX_20019798_ChIP-Seq_JUKART_Human3.62440472
6VDR_21846776_ChIP-Seq_THP-1_Human3.52830054
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.38930126
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.36852030
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04982031
10MAF_26560356_Chip-Seq_TH1_Human2.98952175
11TCF7_22412390_ChIP-Seq_EML_Mouse2.91052616
12UTX_26944678_Chip-Seq_JUKART_Human2.87026308
13MYB_26560356_Chip-Seq_TH2_Human2.85520397
14SCL_19346495_ChIP-Seq_HPC-7_Human2.81625770
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.80161106
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72252614
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.70689252
18KDM2B_26808549_Chip-Seq_DND41_Human2.68248740
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.66271022
20MYB_26560356_Chip-Seq_TH1_Human2.64622131
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62579565
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58516620
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.51838409
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37406724
25VDR_24763502_ChIP-Seq_THP-1_Human2.34859928
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.32803610
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30658889
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24739321
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.18745607
30* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18725404
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.15157233
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09303291
33IRF8_21731497_ChIP-ChIP_J774_Mouse2.05676495
34SPI1_23127762_ChIP-Seq_K562_Human2.05464980
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05045405
36MAF_26560356_Chip-Seq_TH2_Human2.00073324
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.93873875
38GATA3_27048872_Chip-Seq_THYMUS_Human1.89008362
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88296187
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84700386
41CIITA_25753668_ChIP-Seq_RAJI_Human1.82666569
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.80302511
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.75229159
44SPI1_23547873_ChIP-Seq_NB4_Human1.68000097
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59210621
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58355993
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55860403
48E2F7_22180533_ChIP-Seq_HELA_Human1.53270443
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50390578
50* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50324014
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.47728200
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43122733
53GATA1_22025678_ChIP-Seq_K562_Human1.42910570
54LXR_22292898_ChIP-Seq_THP-1_Human1.40831358
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38352469
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37313486
57GATA1_19941826_ChIP-Seq_K562_Human1.30577388
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30050999
59DROSHA_22980978_ChIP-Seq_HELA_Human1.29120212
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28750187
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28537218
62VDR_24787735_ChIP-Seq_THP-1_Human1.28448913
63* BCOR_27268052_Chip-Seq_Bcells_Human1.26448670
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24045620
65* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22453139
66PU_27001747_Chip-Seq_BMDM_Mouse1.22009331
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21389596
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19487663
69NCOR1_26117541_ChIP-Seq_K562_Human1.15215576
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15212148
71* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13587039
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11202466
73* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09222382
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.08729349
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07220611
76GATA3_26560356_Chip-Seq_TH2_Human1.06400215
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05149110
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.05138793
79* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04429518
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03973459
81SPI1_20517297_ChIP-Seq_HL60_Human1.02383582
82* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02287913
83* P300_27268052_Chip-Seq_Bcells_Human1.01748381
84RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01672048
85KDM2B_26808549_Chip-Seq_K562_Human1.01491864
86* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00823317
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.00671835
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00507101
89* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00431970
90* SA1_27219007_Chip-Seq_ERYTHROID_Human1.00093815
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98989759
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98823200
93* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98733906
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98440065
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98381355
96* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98064523
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97630846
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.96763020
99GATA2_19941826_ChIP-Seq_K562_Human0.96732096
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94815912
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94509975
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94123203
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92318942
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90595016
105* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90177092
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.90087642
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89511125
108* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89087746
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.87461356
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87332393
111STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85764566
112CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85555027
113BCL6_27268052_Chip-Seq_Bcells_Human0.84943027
114RARB_27405468_Chip-Seq_BRAIN_Mouse0.83405689
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83276404
116* P68_20966046_ChIP-Seq_HELA_Human0.82305978
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81780772
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79962538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.92355852
2MP0001800_abnormal_humoral_immune3.69355353
3MP0005387_immune_system_phenotype3.65485877
4MP0001790_abnormal_immune_system3.65485877
5MP0000685_abnormal_immune_system3.60858592
6MP0001835_abnormal_antigen_presentation3.54766529
7MP0005671_abnormal_response_to3.25327982
8MP0003303_peritoneal_inflammation3.05798989
9MP0002398_abnormal_bone_marrow2.85882600
10MP0002452_abnormal_antigen_presenting2.85396354
11MP0002420_abnormal_adaptive_immunity2.78497226
12MP0002396_abnormal_hematopoietic_system2.73347791
13MP0001819_abnormal_immune_cell2.72547247
14* MP0002723_abnormal_immune_serum2.70650257
15MP0005000_abnormal_immune_tolerance2.68990224
16MP0003300_gastrointestinal_ulcer2.66421107
17MP0001873_stomach_inflammation2.53331207
18MP0002166_altered_tumor_susceptibility2.51058694
19MP0000716_abnormal_immune_system2.47276382
20MP0004808_abnormal_hematopoietic_stem2.40945642
21MP0000689_abnormal_spleen_morphology2.35073231
22MP0000703_abnormal_thymus_morphology2.34095540
23MP0002722_abnormal_immune_system2.23414523
24MP0009278_abnormal_bone_marrow2.20790013
25MP0003436_decreased_susceptibility_to2.17734701
26MP0003866_abnormal_defecation2.11817579
27MP0005025_abnormal_response_to2.03678929
28MP0008961_abnormal_basal_metabolism2.02995376
29MP0002429_abnormal_blood_cell1.99970750
30MP0009785_altered_susceptibility_to1.96551418
31MP0002405_respiratory_system_inflammati1.93643538
32MP0005464_abnormal_platelet_physiology1.90003437
33MP0004510_myositis1.89145466
34MP0010155_abnormal_intestine_physiology1.89062147
35MP0004947_skin_inflammation1.81863424
36MP0002419_abnormal_innate_immunity1.81180968
37MP0000465_gastrointestinal_hemorrhage1.80477596
38MP0002006_tumorigenesis1.76540107
39MP0009333_abnormal_splenocyte_physiolog1.60690271
40* MP0001845_abnormal_inflammatory_respons1.46850871
41MP0001545_abnormal_hematopoietic_system1.46726580
42MP0005397_hematopoietic_system_phenotyp1.46726580
43MP0002148_abnormal_hypersensitivity_rea1.40525286
44MP0001853_heart_inflammation1.36699084
45MP0002933_joint_inflammation1.36502737
46MP0004381_abnormal_hair_follicle1.27966549
47MP0008569_lethality_at_weaning1.24205847
48MP0005310_abnormal_salivary_gland1.23504966
49MP0002132_abnormal_respiratory_system1.17425890
50MP0005174_abnormal_tail_pigmentation1.13841042
51MP0003787_abnormal_imprinting1.13792321
52MP0008874_decreased_physiological_sensi1.11577594
53MP0003183_abnormal_peptide_metabolism1.11471761
54MP0001879_abnormal_lymphatic_vessel1.11463322
55MP0003045_fibrosis1.08809864
56MP0006082_CNS_inflammation0.97466774
57MP0000569_abnormal_digit_pigmentation0.95768735
58MP0008260_abnormal_autophagy0.95606818
59* MP0009764_decreased_sensitivity_to0.92037904
60MP0001851_eye_inflammation0.91652957
61MP0002009_preneoplasia0.91223205
62MP0003172_abnormal_lysosome_physiology0.86572102
63MP0002019_abnormal_tumor_incidence0.85711347
64MP0002693_abnormal_pancreas_physiology0.85575218
65MP0003724_increased_susceptibility_to0.85370296
66MP0004484_altered_response_of0.84405341
67MP0004130_abnormal_muscle_cell0.83588372
68MP0004883_abnormal_blood_vessel0.83464138
69MP0004859_abnormal_synaptic_plasticity0.81358953
70MP0010368_abnormal_lymphatic_system0.80656361
71MP0003091_abnormal_cell_migration0.78569744
72MP0005451_abnormal_body_composition0.78134593
73* MP0008469_abnormal_protein_level0.76986236
74MP0003828_pulmonary_edema0.76917205
75MP0002163_abnormal_gland_morphology0.76873246
76MP0001348_abnormal_lacrimal_gland0.76540156
77MP0001533_abnormal_skeleton_physiology0.75444222
78MP0002928_abnormal_bile_duct0.75438031
79MP0005076_abnormal_cell_differentiation0.73988534
80MP0002909_abnormal_adrenal_gland0.71266334
81MP0008004_abnormal_stomach_pH0.70586206
82MP0000490_abnormal_crypts_of0.70140852
83MP0000015_abnormal_ear_pigmentation0.67158588
84MP0005075_abnormal_melanosome_morpholog0.67106749
85MP0005167_abnormal_blood-brain_barrier0.66282713
86MP0005058_abnormal_lysosome_morphology0.65479086
87MP0001501_abnormal_sleep_pattern0.65128651
88MP0005084_abnormal_gallbladder_morpholo0.62703080
89MP0003191_abnormal_cellular_cholesterol0.62378360
90MP0010630_abnormal_cardiac_muscle0.61511484
91MP0010234_abnormal_vibrissa_follicle0.60912111
92MP0001663_abnormal_digestive_system0.60196682
93MP0000249_abnormal_blood_vessel0.60001220
94MP0005535_abnormal_body_temperature0.57966533
95MP0002095_abnormal_skin_pigmentation0.57935365
96MP0002136_abnormal_kidney_physiology0.57703294
97MP0000858_altered_metastatic_potential0.57076249
98MP0003075_altered_response_to0.56644729
99MP0001986_abnormal_taste_sensitivity0.55857357
100MP0005166_decreased_susceptibility_to0.54716040
101MP0005390_skeleton_phenotype0.54491520
102MP0002822_catalepsy0.53808517
103MP0004185_abnormal_adipocyte_glucose0.53689043
104MP0003448_altered_tumor_morphology0.52946378
105MP0002998_abnormal_bone_remodeling0.52324442
106MP0001784_abnormal_fluid_regulation0.52277683
107MP0002083_premature_death0.50874655
108MP0001765_abnormal_ion_homeostasis0.50002487
109MP0003943_abnormal_hepatobiliary_system0.49794768
110MP0003690_abnormal_glial_cell0.49328455
111MP0003566_abnormal_cell_adhesion0.48386706
112MP0009763_increased_sensitivity_to0.48085257
113MP0003279_aneurysm0.46874228
114MP0005023_abnormal_wound_healing0.46068547
115MP0000003_abnormal_adipose_tissue0.45769948
116MP0003633_abnormal_nervous_system0.44442766
117MP0005409_darkened_coat_color0.43745086
118MP0002138_abnormal_hepatobiliary_system0.43741928
119MP0005621_abnormal_cell_physiology0.43157598
120MP0010352_gastrointestinal_tract_polyps0.42282755
121MP0006054_spinal_hemorrhage0.41657717

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.14971907
2Panhypogammaglobulinemia (HP:0003139)5.16298240
3T lymphocytopenia (HP:0005403)5.00794275
4Recurrent bronchitis (HP:0002837)4.96643430
5Recurrent viral infections (HP:0004429)4.92030486
6Verrucae (HP:0200043)4.81950678
7Papilloma (HP:0012740)4.81950678
8Abnormality of T cell number (HP:0011839)4.72615407
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.67447339
10Cellulitis (HP:0100658)4.59311470
11Abnormality of the fingertips (HP:0001211)4.43784597
12B lymphocytopenia (HP:0010976)4.38230670
13Abnormality of B cell number (HP:0010975)4.38230670
14Chronic otitis media (HP:0000389)4.36035596
15IgM deficiency (HP:0002850)4.21226724
16Colitis (HP:0002583)4.19428705
17Recurrent fungal infections (HP:0002841)4.16219451
18Inflammation of the large intestine (HP:0002037)4.07033260
19Gastrointestinal inflammation (HP:0004386)4.04863011
20Thyroiditis (HP:0100646)3.90747983
21Meningitis (HP:0001287)3.84517404
22Gastrointestinal stroma tumor (HP:0100723)3.80166133
23Abnormality of T cells (HP:0002843)3.76265741
24Orchitis (HP:0100796)3.73125693
25Retrobulbar optic neuritis (HP:0100654)3.71048510
26Optic neuritis (HP:0100653)3.71048510
27Abnormality of macrophages (HP:0004311)3.63043938
28Chronic mucocutaneous candidiasis (HP:0002728)3.51376748
29Recurrent cutaneous fungal infections (HP:0011370)3.51376748
30Gastrointestinal infarctions (HP:0005244)3.51025160
31Recurrent sinusitis (HP:0011108)3.35030158
32Lymphopenia (HP:0001888)3.34905257
33Chronic sinusitis (HP:0011109)3.32140697
34Severe combined immunodeficiency (HP:0004430)3.26639917
35Nasal polyposis (HP:0100582)3.24466289
36Spontaneous hematomas (HP:0007420)3.23077561
37Abnormality of the nasal mucosa (HP:0000433)3.18863112
38Abnormality of cells of the lymphoid lineage (HP:0012140)3.18557284
39Autoimmune thrombocytopenia (HP:0001973)3.15657196
40Petechiae (HP:0000967)3.13395912
41Pustule (HP:0200039)3.05495787
42Combined immunodeficiency (HP:0005387)3.05142011
43Emphysema (HP:0002097)2.97946601
44Recurrent abscess formation (HP:0002722)2.88180057
45Recurrent gram-negative bacterial infections (HP:0005420)2.83200828
46Gingival bleeding (HP:0000225)2.82020250
47Eczematoid dermatitis (HP:0000976)2.77963904
48Bronchitis (HP:0012387)2.75000478
49Prolonged bleeding time (HP:0003010)2.73632950
50Abnormality of T cell physiology (HP:0011840)2.70627440
51Vasculitis (HP:0002633)2.68924447
52IgG deficiency (HP:0004315)2.68436842
53Vertebral arch anomaly (HP:0008438)2.67661337
54Hypochromic anemia (HP:0001931)2.63581419
55Keratoconjunctivitis sicca (HP:0001097)2.62461920
56Purpura (HP:0000979)2.61944336
57Eosinophilia (HP:0001880)2.61264893
58Mediastinal lymphadenopathy (HP:0100721)2.59208327
59Sepsis (HP:0100806)2.56168441
60Recurrent bacterial skin infections (HP:0005406)2.55658280
61Osteomyelitis (HP:0002754)2.55558267
62Increased IgM level (HP:0003496)2.55010939
63Recurrent otitis media (HP:0000403)2.54753742
64Keratoconjunctivitis (HP:0001096)2.53198806
65Increased IgE level (HP:0003212)2.51335639
66Recurrent skin infections (HP:0001581)2.49917910
67Hypoplasia of the thymus (HP:0000778)2.49866579
68Menorrhagia (HP:0000132)2.48932682
69Pulmonary embolism (HP:0002204)2.48397375
70Macroorchidism (HP:0000053)2.47474708
71Elevated erythrocyte sedimentation rate (HP:0003565)2.45311892
72Urticaria (HP:0001025)2.43135901
73Abnormality of eosinophils (HP:0001879)2.37442155
74Stomatitis (HP:0010280)2.36988231
75Basal cell carcinoma (HP:0002671)2.36665342
76IgA deficiency (HP:0002720)2.35473957
77Restrictive lung disease (HP:0002091)2.34411715
78Acute hepatic failure (HP:0006554)2.31110164
79Increased mean platelet volume (HP:0011877)2.28148992
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27592218
81Granulocytopenia (HP:0001913)2.27544187
82Gingivitis (HP:0000230)2.26296932
83Chronic diarrhea (HP:0002028)2.25931184
84Episodic fever (HP:0001954)2.25779590
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24857764
86Hypochromic microcytic anemia (HP:0004840)2.22793837
87Fatigue (HP:0012378)2.22280913
88Chest pain (HP:0100749)2.21320668
89Papilledema (HP:0001085)2.17888794
90Hyperacusis (HP:0010780)2.15881176
91Interstitial pulmonary disease (HP:0006530)2.15578195
92Abnormality of binocular vision (HP:0011514)2.15511644
93Diplopia (HP:0000651)2.15511644
94Thrombocytosis (HP:0001894)2.10974764
95Leukocytosis (HP:0001974)2.09964350
96Myositis (HP:0100614)2.08167686
97Lymphoma (HP:0002665)2.07884824
98Epistaxis (HP:0000421)2.07204929
99Autoimmune hemolytic anemia (HP:0001890)2.06845428
100Hematochezia (HP:0002573)2.06033774
101Obstructive lung disease (HP:0006536)2.04859319
102Chronic obstructive pulmonary disease (HP:0006510)2.04859319
103Hypergammaglobulinemia (HP:0010702)2.04337066
104Abnormality of the pleura (HP:0002103)2.00801729
105Microcytic anemia (HP:0001935)2.00128966
106Slow saccadic eye movements (HP:0000514)1.99367999
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97883899
108Stomach cancer (HP:0012126)1.97461619
109Mitral stenosis (HP:0001718)1.94635024
110Anorexia (HP:0002039)1.93970670
111Cerebral aneurysm (HP:0004944)1.92193974
112Encephalitis (HP:0002383)1.84821604
113Hemiplegia (HP:0002301)1.84591238
114Skin ulcer (HP:0200042)1.82167401
115Viral hepatitis (HP:0006562)1.80207137
116Long eyelashes (HP:0000527)1.79252840
117Increased density of long bones (HP:0006392)1.76854749
118Abnormal platelet volume (HP:0011876)1.76449869
119Small epiphyses (HP:0010585)1.75418947
120Hemoptysis (HP:0002105)1.75363626
121Recurrent lower respiratory tract infections (HP:0002783)1.74715185
122Acute lymphatic leukemia (HP:0006721)1.73901029
123Abnormality of the intervertebral disk (HP:0005108)1.73787749
124Recurrent pneumonia (HP:0006532)1.73323684
125Pulmonary infiltrates (HP:0002113)1.69773221
126Heterotopia (HP:0002282)1.67701272
127Skin rash (HP:0000988)1.67382509
128Impaired platelet aggregation (HP:0003540)1.65267695
129Abnormal platelet function (HP:0011869)1.65267695
130Ulnar bowing (HP:0003031)1.59773704
131Arterial thrombosis (HP:0004420)1.59211291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.69417014
2MAP3K103.60862306
3PRPF4B2.96171303
4GRK62.84107806
5SIK22.71385530
6EEF2K2.65899938
7TIE12.47974229
8MAP3K132.25507704
9STK102.23007405
10TXK2.12431841
11ZAP702.10632421
12JAK32.05259232
13ITK2.00349726
14TYK21.96501795
15BTK1.91234884
16SYK1.87485432
17FGFR41.75629968
18FES1.71675328
19JAK11.68878696
20RIPK41.64190915
21ERN11.63823763
22PKN21.60630887
23FGFR31.56618642
24HCK1.54293268
25CAMKK21.53348944
26TRIB31.53157086
27MAP3K71.51714242
28CSF1R1.50559913
29PRKCH1.50149396
30CDK121.48556306
31MARK31.45498014
32LRRK21.44587209
33IKBKE1.42759556
34LCK1.41867259
35MAP3K141.40864392
36CSK1.34192072
37MAP3K111.31269155
38TNK21.28332315
39PRKD21.26087847
40CLK11.24794970
41BLK1.23548388
42TGFBR21.21525409
43MAP2K31.21437572
44MARK21.18611174
45TEC1.17712801
46KIT1.17606980
47SMG11.17573406
48BRD41.17356986
49NLK1.12749821
50HIPK21.06291125
51EPHB11.03706938
52PRKCQ0.96293179
53DAPK20.96158860
54TBK10.94171568
55TTN0.93360392
56PTK2B0.91864490
57CAMK1G0.89852745
58MAPK120.87998843
59SGK30.87233457
60PDK10.84966277
61FGFR20.84226489
62JAK20.84216527
63ALK0.82931516
64LYN0.81381825
65MAP3K10.81283360
66IRAK40.78608621
67PIM10.75071376
68IRAK10.74143885
69TAOK10.71695074
70MAPK70.71327724
71TYRO30.68827377
72SIK10.68679250
73PTK60.68111683
74IKBKB0.66412978
75CDK40.66180256
76SIK30.65436743
77BMPR20.65193679
78BMX0.63685230
79IRAK20.63504073
80NEK20.62808222
81RPS6KL10.62147067
82RPS6KC10.62147067
83PRKD10.61705071
84FGR0.61696011
85MAP2K20.61613865
86RIPK10.61249139
87FLT30.61093013
88WNK10.61067971
89PASK0.60798604
90MAPK40.60712795
91STK40.58658511
92STK110.58046671
93MAP3K30.56192110
94PDGFRB0.55404888
95CAMK40.53201058
96CAMK1D0.50452501
97CDC42BPA0.48883906
98SGK20.48807325
99MATK0.48368168
100FYN0.47833729
101RET0.47752138
102KDR0.47000005
103CHUK0.46993508
104CDK190.46963192
105CDK90.46693322
106DMPK0.46383719
107MAPK110.45680951
108TAOK20.45609654
109TESK20.45500612
110RPS6KA20.42224746
111KSR20.40095870
112NTRK20.39857838
113STK380.39779923
114PDPK10.39151889
115CAMK10.39098233
116GRK50.39074954
117TLK10.36424497
118MELK0.36258216
119MAP3K90.35943135
120ABL10.35941623
121TAOK30.35940541
122CDK60.35038385
123RPS6KA60.34821443
124MAP2K60.33750201
125TRPM70.33717455
126CSNK1A1L0.29570356
127CAMKK10.26559376
128DYRK1B0.26416192

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.04624919
2B cell receptor signaling pathway_Homo sapiens_hsa046623.57924926
3T cell receptor signaling pathway_Homo sapiens_hsa046602.65807333
4Allograft rejection_Homo sapiens_hsa053302.58903175
5Autoimmune thyroid disease_Homo sapiens_hsa053202.40238445
6Graft-versus-host disease_Homo sapiens_hsa053322.34089756
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07297214
8Osteoclast differentiation_Homo sapiens_hsa043802.03423132
9Hematopoietic cell lineage_Homo sapiens_hsa046401.97294751
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.96684103
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.93074754
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.87053494
13Type I diabetes mellitus_Homo sapiens_hsa049401.85576321
14Asthma_Homo sapiens_hsa053101.84816430
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.82194131
16Staphylococcus aureus infection_Homo sapiens_hsa051501.73761812
17Measles_Homo sapiens_hsa051621.66611718
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.66128688
19Leishmaniasis_Homo sapiens_hsa051401.63874020
20Chemokine signaling pathway_Homo sapiens_hsa040621.63552202
21Platelet activation_Homo sapiens_hsa046111.56751933
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48248470
23Acute myeloid leukemia_Homo sapiens_hsa052211.48043429
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.45945244
25Chronic myeloid leukemia_Homo sapiens_hsa052201.39066727
26Antigen processing and presentation_Homo sapiens_hsa046121.35065117
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.30886259
28Non-small cell lung cancer_Homo sapiens_hsa052231.30082403
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.29572785
30VEGF signaling pathway_Homo sapiens_hsa043701.17356225
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15648021
32Toxoplasmosis_Homo sapiens_hsa051451.11427386
33Pancreatic cancer_Homo sapiens_hsa052121.10863527
34Inositol phosphate metabolism_Homo sapiens_hsa005621.10367101
35Hepatitis B_Homo sapiens_hsa051611.09718651
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08791830
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05918859
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05696606
39Herpes simplex infection_Homo sapiens_hsa051681.05173399
40Regulation of autophagy_Homo sapiens_hsa041401.04449602
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03830270
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01126115
43Olfactory transduction_Homo sapiens_hsa047400.99497581
44African trypanosomiasis_Homo sapiens_hsa051430.97305668
45Lysine degradation_Homo sapiens_hsa003100.97025432
46Shigellosis_Homo sapiens_hsa051310.96628984
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96524569
48Viral myocarditis_Homo sapiens_hsa054160.96011958
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.95373713
50Influenza A_Homo sapiens_hsa051640.92812277
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91638195
52Type II diabetes mellitus_Homo sapiens_hsa049300.91586591
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90068834
54Long-term potentiation_Homo sapiens_hsa047200.89392141
55Prolactin signaling pathway_Homo sapiens_hsa049170.88924317
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88892152
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88027100
58Morphine addiction_Homo sapiens_hsa050320.87316502
59Rheumatoid arthritis_Homo sapiens_hsa053230.86317491
60Gastric acid secretion_Homo sapiens_hsa049710.86249152
61Tuberculosis_Homo sapiens_hsa051520.86239710
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86096087
63mTOR signaling pathway_Homo sapiens_hsa041500.85873537
64Colorectal cancer_Homo sapiens_hsa052100.85805257
65Notch signaling pathway_Homo sapiens_hsa043300.85477889
66Insulin resistance_Homo sapiens_hsa049310.85066086
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83128294
68Choline metabolism in cancer_Homo sapiens_hsa052310.82624951
69Malaria_Homo sapiens_hsa051440.82411350
70HTLV-I infection_Homo sapiens_hsa051660.80960692
71TNF signaling pathway_Homo sapiens_hsa046680.79688291
72Other glycan degradation_Homo sapiens_hsa005110.79108060
73* MAPK signaling pathway_Homo sapiens_hsa040100.77970939
74Glioma_Homo sapiens_hsa052140.76001079
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75798181
76FoxO signaling pathway_Homo sapiens_hsa040680.75447729
77Dorso-ventral axis formation_Homo sapiens_hsa043200.74990021
78Apoptosis_Homo sapiens_hsa042100.74989473
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73875329
80Hepatitis C_Homo sapiens_hsa051600.73072675
81Salivary secretion_Homo sapiens_hsa049700.72555458
82Endocytosis_Homo sapiens_hsa041440.72023063
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71684689
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70959431
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.70423764
86Estrogen signaling pathway_Homo sapiens_hsa049150.69049915
87GnRH signaling pathway_Homo sapiens_hsa049120.68292555
88Phagosome_Homo sapiens_hsa041450.67796521
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66355311
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66169165
91Endometrial cancer_Homo sapiens_hsa052130.65561960
92Oxytocin signaling pathway_Homo sapiens_hsa049210.64936806
93Rap1 signaling pathway_Homo sapiens_hsa040150.64813869
94Renin secretion_Homo sapiens_hsa049240.64267240
95Cholinergic synapse_Homo sapiens_hsa047250.63973978
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62993589
97Renal cell carcinoma_Homo sapiens_hsa052110.62679911
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61668544
99Epstein-Barr virus infection_Homo sapiens_hsa051690.60789899
100Ras signaling pathway_Homo sapiens_hsa040140.60078576
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.58650239
102Salmonella infection_Homo sapiens_hsa051320.56862344
103Legionellosis_Homo sapiens_hsa051340.56519867
104Circadian entrainment_Homo sapiens_hsa047130.56346756
105Viral carcinogenesis_Homo sapiens_hsa052030.56168614
106Long-term depression_Homo sapiens_hsa047300.56040967
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56023923
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54918959
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54667049
110Small cell lung cancer_Homo sapiens_hsa052220.54094392
111ErbB signaling pathway_Homo sapiens_hsa040120.53917863
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52791420
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.52639709
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51263693
115Proteoglycans in cancer_Homo sapiens_hsa052050.51012619
116Non-homologous end-joining_Homo sapiens_hsa034500.49355379
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49334172
118Insulin signaling pathway_Homo sapiens_hsa049100.49287208
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.49178456
120Pancreatic secretion_Homo sapiens_hsa049720.48955356
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.48885896
122Glutamatergic synapse_Homo sapiens_hsa047240.48855046
123cAMP signaling pathway_Homo sapiens_hsa040240.47788168
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47544909

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