MAP4K4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)3.44557498
2hippo signaling (GO:0035329)3.41412726
3semaphorin-plexin signaling pathway (GO:0071526)3.38098050
4cytoskeletal anchoring at plasma membrane (GO:0007016)3.32048026
5neuron recognition (GO:0008038)3.30838212
6skin morphogenesis (GO:0043589)3.28996712
7embryonic retina morphogenesis in camera-type eye (GO:0060059)3.19054184
8presynaptic membrane organization (GO:0097090)3.16009216
9polarized epithelial cell differentiation (GO:0030859)3.12825097
10negative regulation of catenin import into nucleus (GO:0035414)3.07373599
11positive regulation of dendritic spine morphogenesis (GO:0061003)3.06409214
12postsynaptic membrane organization (GO:0001941)3.06002151
13peripheral nervous system axon ensheathment (GO:0032292)3.05913082
14myelination in peripheral nervous system (GO:0022011)3.05913082
15establishment of nucleus localization (GO:0040023)2.99087903
16layer formation in cerebral cortex (GO:0021819)2.95142137
17planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92445056
18regulation of NFAT protein import into nucleus (GO:0051532)2.89164424
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85710084
20Notch signaling involved in heart development (GO:0061314)2.81434719
21mating behavior (GO:0007617)2.77413770
22presynaptic membrane assembly (GO:0097105)2.74384496
23lateral sprouting from an epithelium (GO:0060601)2.73222852
24cell migration in hindbrain (GO:0021535)2.72549970
25locomotory exploration behavior (GO:0035641)2.70342197
26synaptic vesicle docking involved in exocytosis (GO:0016081)2.69898527
27substrate-dependent cell migration (GO:0006929)2.69115355
28membrane assembly (GO:0071709)2.69007526
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.68369018
30neuron projection extension (GO:1990138)2.68128309
31cortical actin cytoskeleton organization (GO:0030866)2.67513535
32protein heterotrimerization (GO:0070208)2.66550130
33neuronal ion channel clustering (GO:0045161)2.65202624
34axon ensheathment (GO:0008366)2.64731789
35ensheathment of neurons (GO:0007272)2.64731789
36glial cell proliferation (GO:0014009)2.61634146
37neuron remodeling (GO:0016322)2.60587437
38neurotransmitter-gated ion channel clustering (GO:0072578)2.60414775
39myelination (GO:0042552)2.59744794
40dendrite morphogenesis (GO:0048813)2.56748428
41insulin-like growth factor receptor signaling pathway (GO:0048009)2.56417349
42asymmetric protein localization (GO:0008105)2.55250349
43suckling behavior (GO:0001967)2.53737531
44gastrulation with mouth forming second (GO:0001702)2.51566462
45regulation of catenin import into nucleus (GO:0035412)2.51097759
46plasma membrane repair (GO:0001778)2.50043260
47basement membrane organization (GO:0071711)2.48717689
48camera-type eye morphogenesis (GO:0048593)2.47389755
49paraxial mesoderm development (GO:0048339)2.47353585
50developmental cell growth (GO:0048588)2.45661854
51lens fiber cell development (GO:0070307)2.43841487
52cerebellar granule cell differentiation (GO:0021707)2.41650090
53heart morphogenesis (GO:0003007)2.41510534
54positive regulation of axon extension (GO:0045773)2.40923759
55regulation of hippo signaling (GO:0035330)2.38487820
56axon extension involved in axon guidance (GO:0048846)2.38462975
57neuron projection extension involved in neuron projection guidance (GO:1902284)2.38462975
58pre-miRNA processing (GO:0031054)2.38202456
59protein localization to endosome (GO:0036010)2.38178512
60apical protein localization (GO:0045176)2.37219452
61negative regulation of axon extension involved in axon guidance (GO:0048843)2.36037746
62regulation of RNA export from nucleus (GO:0046831)2.35933216
63regulation of axon extension involved in axon guidance (GO:0048841)2.35822163
64bone trabecula formation (GO:0060346)2.35810940
65ganglion development (GO:0061548)2.35335259
66adherens junction assembly (GO:0034333)2.35301405
67axonal fasciculation (GO:0007413)2.34649188
68blood vessel endothelial cell migration (GO:0043534)2.33531703
69nerve growth factor signaling pathway (GO:0038180)2.33435521
70cellular response to prostaglandin stimulus (GO:0071379)2.32384105
71axon ensheathment in central nervous system (GO:0032291)2.31911478
72central nervous system myelination (GO:0022010)2.31911478
73cortical cytoskeleton organization (GO:0030865)2.31357068
74positive regulation of dendritic spine development (GO:0060999)2.30598208
75establishment of cell polarity (GO:0030010)2.29445699
76dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28812475
77forebrain development (GO:0030900)2.28802361
78cellular potassium ion homeostasis (GO:0030007)2.28578596
79NLS-bearing protein import into nucleus (GO:0006607)2.28073375
80Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.27161947
81platelet-derived growth factor receptor signaling pathway (GO:0048008)2.26826631
82regulation of establishment of planar polarity (GO:0090175)2.25900795
83neuromuscular process controlling balance (GO:0050885)2.25201708
84head development (GO:0060322)2.25045618
85astrocyte development (GO:0014002)2.24963998
86hemidesmosome assembly (GO:0031581)2.23741409
87cell communication by electrical coupling (GO:0010644)2.23539538
88protein localization to synapse (GO:0035418)2.23405510
89regulation of axon guidance (GO:1902667)2.23356218
90ventricular trabecula myocardium morphogenesis (GO:0003222)2.22453459
91cell-substrate junction assembly (GO:0007044)2.21647874
92positive regulation of receptor recycling (GO:0001921)2.21176973
93regulation of Rac protein signal transduction (GO:0035020)2.21075066
94establishment of mitochondrion localization (GO:0051654)2.20760336
95neuronal stem cell maintenance (GO:0097150)2.20646570
96neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.20584768
97mitotic cytokinesis (GO:0000281)2.19763413
98branching involved in salivary gland morphogenesis (GO:0060445)2.19722850
99negative regulation of fibrinolysis (GO:0051918)2.19666988
100retina vasculature morphogenesis in camera-type eye (GO:0061299)2.19641485
101vascular endothelial growth factor signaling pathway (GO:0038084)2.19425270
102ionotropic glutamate receptor signaling pathway (GO:0035235)2.19056476
103regulation of glutamate receptor signaling pathway (GO:1900449)2.18669464
104regulation of neuronal synaptic plasticity (GO:0048168)2.18533140
105negative regulation of axon extension (GO:0030517)2.17875469
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.17513594
107cell adhesion mediated by integrin (GO:0033627)2.17402743
108dendritic spine morphogenesis (GO:0060997)2.17076169
109regulation of short-term neuronal synaptic plasticity (GO:0048172)2.17061159
110dorsal/ventral axis specification (GO:0009950)2.16958558
111regulation of early endosome to late endosome transport (GO:2000641)2.16749400
112negative regulation of axon guidance (GO:1902668)2.16732997
113negative regulation of anoikis (GO:2000811)2.15978548
114hypotonic response (GO:0006971)2.15543480
115positive regulation of dendrite morphogenesis (GO:0050775)2.15314905
116peptidyl-lysine dimethylation (GO:0018027)2.14583105
117collagen fibril organization (GO:0030199)2.14571544
118positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.14376932
119glutamate secretion (GO:0014047)2.13102636
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.12508426
121vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.12076056
122nucleus localization (GO:0051647)2.11995536
123positive regulation of p38MAPK cascade (GO:1900745)2.11402375
124establishment or maintenance of bipolar cell polarity (GO:0061245)2.11270956
125establishment or maintenance of apical/basal cell polarity (GO:0035088)2.11270956
126synaptic vesicle maturation (GO:0016188)2.11230926
127central nervous system projection neuron axonogenesis (GO:0021952)2.10651553
128establishment or maintenance of cell polarity (GO:0007163)2.10549513
129regulation of neuron migration (GO:2001222)2.10260313
130non-canonical Wnt signaling pathway (GO:0035567)2.09954573
131germ cell migration (GO:0008354)2.09863529
132axon extension (GO:0048675)2.09509026
133neural tube development (GO:0021915)2.09155316
134chondrocyte proliferation (GO:0035988)2.09118243
135venous blood vessel morphogenesis (GO:0048845)2.08245620
136cell migration involved in sprouting angiogenesis (GO:0002042)2.08221800
137growth hormone receptor signaling pathway (GO:0060396)2.07994035
138regulation of nucleobase-containing compound transport (GO:0032239)2.07818277
139cerebral cortex radially oriented cell migration (GO:0021799)2.07447676
140renal filtration (GO:0097205)2.07245707
141adherens junction organization (GO:0034332)2.07205087
142outer ear morphogenesis (GO:0042473)2.06678330
143endodermal cell differentiation (GO:0035987)2.06410229
144cardiac myofibril assembly (GO:0055003)2.05945830
145dermatan sulfate biosynthetic process (GO:0030208)2.05464192
146cochlea morphogenesis (GO:0090103)2.05189210
147negative regulation of translation, ncRNA-mediated (GO:0040033)2.04374416
148regulation of translation, ncRNA-mediated (GO:0045974)2.04374416
149negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.04374416
150negative regulation of chondrocyte differentiation (GO:0032331)2.04173632
151response to nerve growth factor (GO:1990089)2.03719451
152cellular response to nerve growth factor stimulus (GO:1990090)2.03719451
153protein localization to cell surface (GO:0034394)2.03549434
154establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.02361284
155eye morphogenesis (GO:0048592)2.01940169
156stress fiber assembly (GO:0043149)2.01359206
157embryonic camera-type eye development (GO:0031076)2.00942745
158glomerular filtration (GO:0003094)2.00928390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human2.89919700
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88766320
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.84092774
4EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.83005894
5* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.51965063
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.42851164
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.34254246
8* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.24669357
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.17116553
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.10139752
11* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.01358445
12* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98927363
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96439729
14* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93522708
15* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93033095
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91569363
17KDM2B_26808549_Chip-Seq_DND41_Human1.89456720
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.82599156
19* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82183951
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77940722
21* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76186539
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72896553
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71397030
24KDM2B_26808549_Chip-Seq_K562_Human1.71271356
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70941956
26KDM2B_26808549_Chip-Seq_JURKAT_Human1.69367796
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.68297572
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67388767
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65825210
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62212752
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62212752
32CLOCK_20551151_ChIP-Seq_293T_Human1.61818138
33ISL1_27105846_Chip-Seq_CPCs_Mouse1.60419140
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.59557930
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55452387
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54691376
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.54461083
38* RING1B_27294783_Chip-Seq_NPCs_Mouse1.53258977
39FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.52230506
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51820966
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50624636
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48567692
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.47970096
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.46702527
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45127059
46TP53_16413492_ChIP-PET_HCT116_Human1.44097156
47DROSHA_22980978_ChIP-Seq_HELA_Human1.43994474
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42448979
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.40101812
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39814228
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39251115
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38643504
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37798789
54GBX2_23144817_ChIP-Seq_PC3_Human1.37147801
55* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37083858
56AR_21572438_ChIP-Seq_LNCaP_Human1.36481053
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32023781
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30207611
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.29458222
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.28776141
61AHR_22903824_ChIP-Seq_MCF-7_Human1.28541402
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27155475
63* BRD4_25478319_ChIP-Seq_HGPS_Human1.24797815
64* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22863637
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22152471
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22152471
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22152471
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20794207
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19785200
70* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18467273
71* TCF7_22412390_ChIP-Seq_EML_Mouse1.18202642
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.18146506
73EZH2_22144423_ChIP-Seq_EOC_Human1.17453734
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15810306
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14533946
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14434895
77* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14359100
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14358636
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13511298
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11824048
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11804825
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11779716
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11382098
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11275002
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.10244622
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10180731
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09726764
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.09651515
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.09418987
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09009865
91* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08631714
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07554865
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06931512
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06691460
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06613334
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06463461
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06160276
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05884108
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.05843359
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.05736408
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05216034
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04870234
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04294334
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03985691
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03946046
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.03932173
107MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02226296
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.02069765
109* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01667068
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01504707
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01252348
112REST_21632747_ChIP-Seq_MESCs_Mouse1.01124796
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.00994156
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00786776
115* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00403609
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98269732
117* GATA2_21666600_ChIP-Seq_HMVEC_Human0.97789336
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.97626743
119* TBX20_22328084_ChIP-Seq_HEART_Mouse0.96782836
120* TBX20_22080862_ChIP-Seq_HEART_Mouse0.96782836
121* CJUN_26792858_Chip-Seq_BT549_Human0.96456079
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95550943
123* TP53_23651856_ChIP-Seq_MEFs_Mouse0.95385025
124* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94513800
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94082796
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93994999
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93994999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.45221426
2MP0004859_abnormal_synaptic_plasticity3.39217593
3MP0010368_abnormal_lymphatic_system3.32675593
4MP0005623_abnormal_meninges_morphology3.32253915
5MP0003705_abnormal_hypodermis_morpholog2.78799823
6MP0005409_darkened_coat_color2.75748725
7MP0004270_analgesia2.46231324
8MP0004272_abnormal_basement_membrane2.36566599
9MP0000537_abnormal_urethra_morphology2.31502933
10MP0000733_abnormal_muscle_development2.28406265
11MP0000569_abnormal_digit_pigmentation2.26654218
12MP0006054_spinal_hemorrhage2.23105900
13MP0005076_abnormal_cell_differentiation2.21547247
14MP0003385_abnormal_body_wall1.97773544
15MP0001299_abnormal_eye_distance/1.90627115
16MP0003123_paternal_imprinting1.89873489
17MP0000778_abnormal_nervous_system1.88786172
18MP0003329_amyloid_beta_deposits1.82795285
19MP0003091_abnormal_cell_migration1.76625330
20MP0005275_abnormal_skin_tensile1.73264599
21MP0000428_abnormal_craniofacial_morphol1.67870383
22MP0010352_gastrointestinal_tract_polyps1.67382223
23MP0003690_abnormal_glial_cell1.64971519
24MP0005423_abnormal_somatic_nervous1.62401024
25MP0005503_abnormal_tendon_morphology1.59701111
26MP0009278_abnormal_bone_marrow1.54030697
27MP0004185_abnormal_adipocyte_glucose1.53898363
28MP0000955_abnormal_spinal_cord1.51287630
29MP0003635_abnormal_synaptic_transmissio1.50721129
30MP0004858_abnormal_nervous_system1.50537762
31MP0009053_abnormal_anal_canal1.46564171
32MP0010030_abnormal_orbit_morphology1.44364955
33* MP0003937_abnormal_limbs/digits/tail_de1.41876276
34MP0001348_abnormal_lacrimal_gland1.39786740
35MP0001958_emphysema1.39754346
36MP0003279_aneurysm1.39356928
37MP0000534_abnormal_ureter_morphology1.38851954
38MP0003755_abnormal_palate_morphology1.37867219
39MP0003566_abnormal_cell_adhesion1.37553842
40MP0004197_abnormal_fetal_growth/weight/1.37491394
41MP0003935_abnormal_craniofacial_develop1.36550142
42MP0004811_abnormal_neuron_physiology1.34254147
43MP0003121_genomic_imprinting1.32390924
44MP0009250_abnormal_appendicular_skeleto1.30756464
45MP0003115_abnormal_respiratory_system1.30712407
46MP0001849_ear_inflammation1.29801279
47MP0004134_abnormal_chest_morphology1.28147832
48MP0003942_abnormal_urinary_system1.27387935
49MP0003122_maternal_imprinting1.25370631
50MP0009780_abnormal_chondrocyte_physiolo1.24394041
51MP0003861_abnormal_nervous_system1.24181505
52MP0002697_abnormal_eye_size1.23650177
53MP0002063_abnormal_learning/memory/cond1.22457893
54MP0005171_absent_coat_pigmentation1.21460153
55MP0010678_abnormal_skin_adnexa1.21165682
56MP0002184_abnormal_innervation1.20347345
57MP0000751_myopathy1.20003853
58MP0000432_abnormal_head_morphology1.19117532
59MP0002925_abnormal_cardiovascular_devel1.18272493
60* MP0002084_abnormal_developmental_patter1.16917171
61MP0003045_fibrosis1.16203871
62MP0000920_abnormal_myelination1.15800296
63MP0003283_abnormal_digestive_organ1.14271414
64MP0005023_abnormal_wound_healing1.13717257
65MP0002116_abnormal_craniofacial_bone1.12924401
66MP0004885_abnormal_endolymph1.11370940
67MP0002734_abnormal_mechanical_nocicepti1.10848016
68MP0004084_abnormal_cardiac_muscle1.10585660
69MP0002282_abnormal_trachea_morphology1.10123769
70MP0002108_abnormal_muscle_morphology1.06701761
71MP0003632_abnormal_nervous_system1.05549820
72MP0003634_abnormal_glial_cell1.05548958
73MP0002932_abnormal_joint_morphology1.05402619
74MP0003567_abnormal_fetal_cardiomyocyte1.05143287
75MP0002092_abnormal_eye_morphology1.04709329
76MP0003950_abnormal_plasma_membrane1.04250314
77MP0005508_abnormal_skeleton_morphology1.03806259
78* MP0002085_abnormal_embryonic_tissue1.03416217
79MP0002882_abnormal_neuron_morphology1.02667700
80MP0000383_abnormal_hair_follicle1.02411720
81MP0003300_gastrointestinal_ulcer1.02108027
82MP0010630_abnormal_cardiac_muscle1.00643064
83MP0004087_abnormal_muscle_fiber1.00505156
84MP0005257_abnormal_intraocular_pressure1.00233394
85MP0000049_abnormal_middle_ear1.00142432
86MP0003880_abnormal_central_pattern1.00083889
87MP0003119_abnormal_digestive_system0.99218002
88MP0005187_abnormal_penis_morphology0.98830097
89MP0003787_abnormal_imprinting0.98219763
90MP0010234_abnormal_vibrissa_follicle0.97199102
91MP0005248_abnormal_Harderian_gland0.96826136
92MP0002233_abnormal_nose_morphology0.96270563
93MP0002653_abnormal_ependyma_morphology0.95973796
94MP0009384_cardiac_valve_regurgitation0.95388319
95MP0000767_abnormal_smooth_muscle0.94636525
96MP0002896_abnormal_bone_mineralization0.94017367
97MP0001177_atelectasis0.93858515
98MP0002249_abnormal_larynx_morphology0.93051992
99MP0005375_adipose_tissue_phenotype0.91564802
100MP0002735_abnormal_chemical_nociception0.90986894
101MP0002877_abnormal_melanocyte_morpholog0.89982069
102MP0000467_abnormal_esophagus_morphology0.89953232
103MP0005666_abnormal_adipose_tissue0.89874703
104MP0003303_peritoneal_inflammation0.89673044
105MP0001486_abnormal_startle_reflex0.89464922
106MP0001915_intracranial_hemorrhage0.89312799
107MP0002081_perinatal_lethality0.88809006
108MP0000762_abnormal_tongue_morphology0.88285250
109MP0002089_abnormal_postnatal_growth/wei0.87952976
110MP0000566_synostosis0.87583900
111MP0002111_abnormal_tail_morphology0.86385844
112MP0002128_abnormal_blood_circulation0.84360653
113MP0001879_abnormal_lymphatic_vessel0.84166323
114MP0000003_abnormal_adipose_tissue0.83794091
115MP0005197_abnormal_uvea_morphology0.82912209
116MP0001784_abnormal_fluid_regulation0.82855075
117MP0008569_lethality_at_weaning0.81059799
118MP0002114_abnormal_axial_skeleton0.80699939
119MP0003315_abnormal_perineum_morphology0.80509401
120MP0003890_abnormal_embryonic-extraembry0.80478624
121MP0001293_anophthalmia0.80077322
122MP0001614_abnormal_blood_vessel0.79728647
123MP0001340_abnormal_eyelid_morphology0.79680343
124* MP0002088_abnormal_embryonic_growth/wei0.79679832
125MP0002152_abnormal_brain_morphology0.79497093
126* MP0003984_embryonic_growth_retardation0.79363430
127MP0002086_abnormal_extraembryonic_tissu0.79244738
128MP0000462_abnormal_digestive_system0.78977158
129MP0003633_abnormal_nervous_system0.78947495
130MP0003631_nervous_system_phenotype0.76879924
131MP0001943_abnormal_respiration0.73971592
132MP0003868_abnormal_feces_composition0.73266372
133MP0002064_seizures0.70681954
134MP0000604_amyloidosis0.69427124
135MP0002572_abnormal_emotion/affect_behav0.67643096
136MP0002060_abnormal_skin_morphology0.67557509

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.91212304
2Short 4th metacarpal (HP:0010044)3.25991072
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.25991072
4Neurofibrillary tangles (HP:0002185)3.12363582
5Premature rupture of membranes (HP:0001788)3.09086412
6Neonatal short-limb short stature (HP:0008921)3.03666105
7Protrusio acetabuli (HP:0003179)2.83956482
8Vertebral arch anomaly (HP:0008438)2.81313014
9Bladder diverticulum (HP:0000015)2.81084307
10Cerebral aneurysm (HP:0004944)2.77866439
11Abnormality of the 4th metacarpal (HP:0010012)2.72818507
12Hyperacusis (HP:0010780)2.63022515
13Deep venous thrombosis (HP:0002625)2.58003107
14Cerebral inclusion bodies (HP:0100314)2.56736366
15Termporal pattern (HP:0011008)2.56042238
16Insidious onset (HP:0003587)2.56042238
17Obstructive sleep apnea (HP:0002870)2.55809265
18Ankle contracture (HP:0006466)2.49802963
19Overriding aorta (HP:0002623)2.45955769
20Broad metatarsal (HP:0001783)2.41769300
21Renal duplication (HP:0000075)2.41709881
22Scapular winging (HP:0003691)2.40001760
23Macroorchidism (HP:0000053)2.38448900
24Flat cornea (HP:0007720)2.21130509
25Peritonitis (HP:0002586)2.16270725
26Renovascular hypertension (HP:0100817)2.16270473
27Bowel diverticulosis (HP:0005222)2.13801959
28Mild short stature (HP:0003502)2.13614296
29Mitral valve prolapse (HP:0001634)2.13585899
30Elfin facies (HP:0004428)2.13137450
31Trigonocephaly (HP:0000243)2.10242051
32Abnormality of dentin (HP:0010299)2.09910271
33Buphthalmos (HP:0000557)2.09110517
34Subacute progressive viral hepatitis (HP:0006572)2.06829852
35Coronal craniosynostosis (HP:0004440)2.04337703
36Chin dimple (HP:0010751)2.01752414
37Asymmetry of the thorax (HP:0001555)2.01639728
38Difficulty running (HP:0009046)2.01446370
39Hepatoblastoma (HP:0002884)2.00818525
40Arnold-Chiari malformation (HP:0002308)2.00593957
41Aortic dissection (HP:0002647)2.00076751
42Broad ribs (HP:0000885)1.99047883
43Deviation of the hallux (HP:0010051)1.98343519
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98021270
45Atrophic scars (HP:0001075)1.97166097
46Genu recurvatum (HP:0002816)1.94937999
47Vitreoretinal degeneration (HP:0000655)1.94143077
48Fragile skin (HP:0001030)1.90243049
49Astrocytoma (HP:0009592)1.90117751
50Abnormality of the astrocytes (HP:0100707)1.90117751
51Hallux valgus (HP:0001822)1.89814300
52Supernumerary ribs (HP:0005815)1.89536314
53Hammertoe (HP:0001765)1.89228589
54Overgrowth (HP:0001548)1.88980780
55Aqueductal stenosis (HP:0002410)1.88711752
56Supranuclear gaze palsy (HP:0000605)1.85576992
57Dilatation of the ascending aorta (HP:0005111)1.85316971
58Megalencephaly (HP:0001355)1.84158026
59Persistence of primary teeth (HP:0006335)1.84086239
60Scanning speech (HP:0002168)1.83567105
61Abnormality of the lower motor neuron (HP:0002366)1.82857274
62Broad palm (HP:0001169)1.82649338
63Abnormality of the diencephalon (HP:0010662)1.81942425
64Action tremor (HP:0002345)1.81792813
65Ankyloglossia (HP:0010296)1.80467505
66Pulmonic stenosis (HP:0001642)1.80003168
67Ulnar bowing (HP:0003031)1.79018454
68Pointed chin (HP:0000307)1.78621154
69Broad thumb (HP:0011304)1.77577241
70Esophageal atresia (HP:0002032)1.76954340
71Wrist flexion contracture (HP:0001239)1.76009135
72Aortic aneurysm (HP:0004942)1.75316222
73Wormian bones (HP:0002645)1.74533097
74Hypoplasia of the iris (HP:0007676)1.73739690
75Lower limb amyotrophy (HP:0007210)1.73724560
76Insomnia (HP:0100785)1.73655650
77Increased connective tissue (HP:0009025)1.73005296
78Large earlobe (HP:0009748)1.72727848
79Increased nuchal translucency (HP:0010880)1.72586438
80Biconcave vertebral bodies (HP:0004586)1.71408074
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71172854
82Tibial bowing (HP:0002982)1.70483158
83Increased density of long bones (HP:0006392)1.69030246
84Lymphangioma (HP:0100764)1.68146331
85Morphological abnormality of the middle ear (HP:0008609)1.67988689
86Cubitus valgus (HP:0002967)1.67693429
87Decreased motor nerve conduction velocity (HP:0003431)1.66442823
88Skull defect (HP:0001362)1.65635775
89Disproportionate tall stature (HP:0001519)1.65264017
90Distal upper limb amyotrophy (HP:0007149)1.65241418
91Upper limb amyotrophy (HP:0009129)1.65241418
92Hypoplastic ischia (HP:0003175)1.63980667
93Thoracolumbar scoliosis (HP:0002944)1.63928001
94Hypoventilation (HP:0002791)1.63819081
95Hyporeflexia of lower limbs (HP:0002600)1.63809461
96Narrow palate (HP:0000189)1.63676385
97Relative macrocephaly (HP:0004482)1.63505742
98Epiphyseal dysplasia (HP:0002656)1.63402021
99Soft skin (HP:0000977)1.63059818
100Fibrous tissue neoplasm (HP:0012316)1.62848416
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.61915179
102Degeneration of the lateral corticospinal tracts (HP:0002314)1.61915179
103Arterial tortuosity (HP:0005116)1.61855681
104Exostoses (HP:0100777)1.61800532
105Fibroma (HP:0010614)1.61757717
106Midline defect of the nose (HP:0004122)1.61625359
107Vascular tortuosity (HP:0004948)1.60620585
108Thin ribs (HP:0000883)1.60331288
109Heterotopia (HP:0002282)1.59726848
110Hyperextensible skin (HP:0000974)1.58572540
111Bronchomalacia (HP:0002780)1.58199107
112Wide anterior fontanel (HP:0000260)1.57781809
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.57028653
114Small epiphyses (HP:0010585)1.56891096
115Aplasia involving bones of the extremities (HP:0009825)1.56825554
116Aplasia involving bones of the upper limbs (HP:0009823)1.56825554
117Aplasia of the phalanges of the hand (HP:0009802)1.56825554
118Abnormality of the corticospinal tract (HP:0002492)1.56212221
119Increased variability in muscle fiber diameter (HP:0003557)1.56015161
120Deviation of the thumb (HP:0009603)1.55609732
121Abnormality of the ischium (HP:0003174)1.55042726
122Onion bulb formation (HP:0003383)1.54424959
123Supernumerary bones of the axial skeleton (HP:0009144)1.54266670
124Hand muscle atrophy (HP:0009130)1.53833382
125Spinal rigidity (HP:0003306)1.52709668
126Long eyelashes (HP:0000527)1.52434650
127Absent frontal sinuses (HP:0002688)1.52341989
128Dislocated radial head (HP:0003083)1.52187510
129Cervical subluxation (HP:0003308)1.51767502
130Exotropia (HP:0000577)1.51547360
131Leiomyosarcoma (HP:0100243)1.51521616
132Uterine leiomyosarcoma (HP:0002891)1.51521616
133Cortical dysplasia (HP:0002539)1.50921646
134Mitral regurgitation (HP:0001653)1.50570966
135Peripheral hypomyelination (HP:0007182)1.50505675
136Distal lower limb amyotrophy (HP:0008944)1.50269441
137Limited elbow extension (HP:0001377)1.50107752
138Turricephaly (HP:0000262)1.49882696
139Missing ribs (HP:0000921)1.49786894
140Syringomyelia (HP:0003396)1.49736405
141Spinal cord lesions (HP:0100561)1.49736405
142Cupped ribs (HP:0000887)1.49716902
143Joint laxity (HP:0001388)1.49567977
144Limited hip movement (HP:0008800)1.49535430
145Broad long bones (HP:0005622)1.49057391
146Blue sclerae (HP:0000592)1.48452128
147Aneurysm (HP:0002617)1.48148821
148Transitional cell carcinoma of the bladder (HP:0006740)1.47418867
149Anteriorly placed anus (HP:0001545)1.47362193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK2.89513974
2TYRO32.80717552
3TRIB32.75183044
4PDGFRA2.64335167
5CDK122.62689723
6EPHB12.34331870
7TTN2.33623679
8DDR22.31544083
9PKN22.31518770
10EEF2K2.17617923
11CASK2.15041186
12LATS12.14586983
13MARK12.02611167
14MAP3K101.91336069
15PDGFRB1.83387412
16EPHB21.81875331
17FGFR21.81252604
18TNIK1.79682309
19NTRK31.78704158
20RIPK11.69992530
21PTK61.68227038
22CAMK1G1.62494274
23DMPK1.62228995
24FGFR41.57808580
25BMX1.55028794
26MAP3K91.53164421
27TIE11.52323214
28MOS1.50121436
29PAK61.49689671
30SIK11.45556074
31BRD41.44444846
32MTOR1.38722007
33MET1.30825969
34ALK1.30119343
35CSNK1A1L1.26561847
36SGK31.25385549
37SIK21.25342332
38MINK11.25209976
39PAK21.25012951
40CAMK1D1.19639957
41STK391.19623424
42SGK2231.17973754
43SGK4941.17973754
44PAK31.17849842
45LATS21.15296922
46SGK21.14964315
47ROCK21.14615311
48RET1.11799010
49PTK21.11338553
50PKN11.07259002
51FGFR11.07239455
52LIMK11.03664266
53UHMK10.99698255
54TGFBR20.99250314
55PNCK0.98391671
56FGR0.98228802
57CDK60.98151931
58PRKD30.96443543
59EPHA30.96427796
60KSR10.95055766
61WNK10.94228867
62STK380.93587403
63MARK20.92288303
64MAP3K60.91823635
65ROCK10.91760987
66PAK40.90611803
67EPHA40.84202229
68MKNK10.83881503
69CDK50.83869927
70STK30.81906803
71FER0.78782913
72YES10.78295923
73BCR0.77605099
74CSNK1G30.77287843
75ILK0.77275421
76CLK10.76423371
77RPS6KB20.74984457
78PRKD10.73486807
79CSNK1G10.72581941
80DYRK1B0.72364611
81ERBB20.72326282
82NTRK20.72146751
83LRRK20.69209259
84FGFR30.69078568
85CSNK1D0.67946031
86MAPK100.67756075
87INSR0.66666660
88NTRK10.66640704
89CSNK1G20.66316651
90RPS6KA20.64533963
91STK110.62506255
92PRKCH0.61225356
93ERBB30.60610027
94GSK3A0.60398812
95ERBB40.60316139
96CDC42BPA0.59924396
97STK100.58342793
98TRPM70.56955540
99PHKG20.56884227
100PHKG10.56884227
101NEK90.54946780
102CDK140.54748477
103DYRK20.53716646
104CDK150.53599249
105PLK20.52139944
106DYRK1A0.51982163
107PRPF4B0.51574098
108MAPK130.50447741
109SGK10.50147327
110AKT30.49848204
111MKNK20.47681078
112CDK11A0.47591032
113SRC0.46245325
114KSR20.46143191
115CHUK0.45953434
116CDK180.45683469
117CDK90.45624046
118FYN0.45413555
119ARAF0.45110307
120CAMKK10.43809789
121WNK40.43808169
122IRAK30.42873641
123TGFBR10.42465968
124CSK0.41681995
125CDC70.41134397
126PRKD20.40213617
127PRKDC0.40203116
128MELK0.39942707
129NEK20.39718935
130CHEK10.39379366
131CAMK2B0.37928809
132PRKCG0.35885800
133CSNK1E0.34601963
134LMTK20.33583189
135PRKCZ0.33562175
136FES0.32958404

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.07795405
2Basal cell carcinoma_Homo sapiens_hsa052171.90660112
3ECM-receptor interaction_Homo sapiens_hsa045121.88919713
4Focal adhesion_Homo sapiens_hsa045101.85104758
5MicroRNAs in cancer_Homo sapiens_hsa052061.77918762
6Viral myocarditis_Homo sapiens_hsa054161.76126069
7Adherens junction_Homo sapiens_hsa045201.73726388
8Hippo signaling pathway_Homo sapiens_hsa043901.71711441
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71259394
10Chronic myeloid leukemia_Homo sapiens_hsa052201.69319011
11Proteoglycans in cancer_Homo sapiens_hsa052051.68315749
12Renal cell carcinoma_Homo sapiens_hsa052111.68124842
13Long-term potentiation_Homo sapiens_hsa047201.62096922
14Hedgehog signaling pathway_Homo sapiens_hsa043401.58054959
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56376865
16Colorectal cancer_Homo sapiens_hsa052101.53146001
17Small cell lung cancer_Homo sapiens_hsa052221.52922752
18Prion diseases_Homo sapiens_hsa050201.52357332
19Endometrial cancer_Homo sapiens_hsa052131.52074385
20Glioma_Homo sapiens_hsa052141.42877539
21Notch signaling pathway_Homo sapiens_hsa043301.41763334
22Dorso-ventral axis formation_Homo sapiens_hsa043201.41472451
23Dilated cardiomyopathy_Homo sapiens_hsa054141.38729787
24Tight junction_Homo sapiens_hsa045301.37422261
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35654262
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33999740
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33316956
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32170615
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28911300
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28904005
31Pancreatic cancer_Homo sapiens_hsa052121.28581666
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.26306192
33Wnt signaling pathway_Homo sapiens_hsa043101.22950356
34ErbB signaling pathway_Homo sapiens_hsa040121.22180384
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22138552
36Glutamatergic synapse_Homo sapiens_hsa047241.19357176
37mTOR signaling pathway_Homo sapiens_hsa041501.18558451
38Prostate cancer_Homo sapiens_hsa052151.17964191
39TGF-beta signaling pathway_Homo sapiens_hsa043501.14371097
40Amoebiasis_Homo sapiens_hsa051461.13460479
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.12512437
42VEGF signaling pathway_Homo sapiens_hsa043701.11788230
43Pathways in cancer_Homo sapiens_hsa052001.10314870
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.09899060
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.09651162
46Rap1 signaling pathway_Homo sapiens_hsa040151.08254569
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08009418
48Non-small cell lung cancer_Homo sapiens_hsa052231.07622515
49Estrogen signaling pathway_Homo sapiens_hsa049151.06248725
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05249144
51Dopaminergic synapse_Homo sapiens_hsa047281.04592432
52Melanoma_Homo sapiens_hsa052181.03801201
53Nicotine addiction_Homo sapiens_hsa050331.02479901
54Gap junction_Homo sapiens_hsa045401.01226604
55Melanogenesis_Homo sapiens_hsa049160.98604970
56Thyroid cancer_Homo sapiens_hsa052160.97837622
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97151821
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95935793
59Cocaine addiction_Homo sapiens_hsa050300.95410878
60Platelet activation_Homo sapiens_hsa046110.94070350
61Circadian entrainment_Homo sapiens_hsa047130.93316934
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93103678
63mRNA surveillance pathway_Homo sapiens_hsa030150.92827521
64HTLV-I infection_Homo sapiens_hsa051660.91845295
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90875308
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90258041
67Ras signaling pathway_Homo sapiens_hsa040140.90011907
68Type II diabetes mellitus_Homo sapiens_hsa049300.89317335
69Complement and coagulation cascades_Homo sapiens_hsa046100.89034139
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88571004
71Toxoplasmosis_Homo sapiens_hsa051450.88114392
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87502125
73T cell receptor signaling pathway_Homo sapiens_hsa046600.85484024
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.85363717
75Bladder cancer_Homo sapiens_hsa052190.85133226
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85025164
77Choline metabolism in cancer_Homo sapiens_hsa052310.84809515
78* MAPK signaling pathway_Homo sapiens_hsa040100.84654770
79Endocytosis_Homo sapiens_hsa041440.84074543
80GnRH signaling pathway_Homo sapiens_hsa049120.83224262
81Thyroid hormone synthesis_Homo sapiens_hsa049180.82532096
82cAMP signaling pathway_Homo sapiens_hsa040240.81918574
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80898662
84GABAergic synapse_Homo sapiens_hsa047270.80746753
85Oxytocin signaling pathway_Homo sapiens_hsa049210.80325708
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.79515444
87Amphetamine addiction_Homo sapiens_hsa050310.79366842
88Lysine degradation_Homo sapiens_hsa003100.79120469
89Acute myeloid leukemia_Homo sapiens_hsa052210.78368950
90Insulin signaling pathway_Homo sapiens_hsa049100.77848376
91FoxO signaling pathway_Homo sapiens_hsa040680.75868836
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75797816
93Cholinergic synapse_Homo sapiens_hsa047250.74892318
94Viral carcinogenesis_Homo sapiens_hsa052030.74343952
95Long-term depression_Homo sapiens_hsa047300.74135799
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74027426
97B cell receptor signaling pathway_Homo sapiens_hsa046620.73900731
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73753645
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73531430
100Insulin secretion_Homo sapiens_hsa049110.73414052
101Gastric acid secretion_Homo sapiens_hsa049710.72441117
102Morphine addiction_Homo sapiens_hsa050320.71973637
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71804101
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71676010
105Chemokine signaling pathway_Homo sapiens_hsa040620.70762164
106Salmonella infection_Homo sapiens_hsa051320.70753655
107AMPK signaling pathway_Homo sapiens_hsa041520.70244263
108Prolactin signaling pathway_Homo sapiens_hsa049170.70003660
109Osteoclast differentiation_Homo sapiens_hsa043800.69713762
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66802029
111Shigellosis_Homo sapiens_hsa051310.65650858
112Renin secretion_Homo sapiens_hsa049240.65622571
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64914929
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63867302
115TNF signaling pathway_Homo sapiens_hsa046680.63214305
116Inositol phosphate metabolism_Homo sapiens_hsa005620.62403206
117Protein digestion and absorption_Homo sapiens_hsa049740.62221228
118Hepatitis B_Homo sapiens_hsa051610.62155503
119HIF-1 signaling pathway_Homo sapiens_hsa040660.60785066
120Insulin resistance_Homo sapiens_hsa049310.60166146
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60158474
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59694153

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