MAP4K5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)4.84956281
2axon ensheathment in central nervous system (GO:0032291)4.84956281
3apical protein localization (GO:0045176)3.56185463
4myelination (GO:0042552)3.49364202
5presynaptic membrane assembly (GO:0097105)3.47766853
6axon ensheathment (GO:0008366)3.47232473
7ensheathment of neurons (GO:0007272)3.47232473
8mesodermal cell differentiation (GO:0048333)3.30523212
9hippo signaling (GO:0035329)3.29710748
10chondrocyte proliferation (GO:0035988)3.27604805
11pyrimidine nucleobase catabolic process (GO:0006208)3.23762079
12asymmetric protein localization (GO:0008105)3.22175730
13presynaptic membrane organization (GO:0097090)3.17316705
14peripheral nervous system axon ensheathment (GO:0032292)3.02214139
15myelination in peripheral nervous system (GO:0022011)3.02214139
16endocardial cushion development (GO:0003197)2.95763148
17limb bud formation (GO:0060174)2.94695139
18paraxial mesoderm development (GO:0048339)2.93967754
19cytoskeletal anchoring at plasma membrane (GO:0007016)2.93157942
20establishment of nucleus localization (GO:0040023)2.92517267
21response to methylmercury (GO:0051597)2.88132938
22artery development (GO:0060840)2.86357130
23central nervous system projection neuron axonogenesis (GO:0021952)2.84419056
24protein localization to endosome (GO:0036010)2.83357158
25lateral sprouting from an epithelium (GO:0060601)2.78906516
26negative regulation of axon guidance (GO:1902668)2.78122769
27neuron recognition (GO:0008038)2.75760034
28negative chemotaxis (GO:0050919)2.75752819
29cerebral cortex cell migration (GO:0021795)2.74876016
30collagen fibril organization (GO:0030199)2.74389159
31craniofacial suture morphogenesis (GO:0097094)2.70323326
32substrate-dependent cell migration (GO:0006929)2.66804221
33retina vasculature morphogenesis in camera-type eye (GO:0061299)2.62692097
34extracellular matrix assembly (GO:0085029)2.61207045
35cerebral cortex radially oriented cell migration (GO:0021799)2.60901904
36negative regulation of protein localization to cell surface (GO:2000009)2.60685104
37photoreceptor cell differentiation (GO:0046530)2.59184385
38eye photoreceptor cell differentiation (GO:0001754)2.59184385
39interkinetic nuclear migration (GO:0022027)2.58247201
40sequestering of extracellular ligand from receptor (GO:0035581)2.57108121
41phospholipid translocation (GO:0045332)2.56715104
42lipid translocation (GO:0034204)2.56715104
43axon extension (GO:0048675)2.56644632
44plasma membrane repair (GO:0001778)2.54960465
45dendrite morphogenesis (GO:0048813)2.54734250
46polarized epithelial cell differentiation (GO:0030859)2.53903305
47myelin maintenance (GO:0043217)2.53379196
48camera-type eye morphogenesis (GO:0048593)2.53247833
49regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.52250813
50negative regulation of catenin import into nucleus (GO:0035414)2.51154844
51lymph vessel development (GO:0001945)2.49309899
52bone trabecula formation (GO:0060346)2.47748377
53positive regulation of neurological system process (GO:0031646)2.47125425
54microtubule anchoring (GO:0034453)2.47068084
55long-chain fatty acid biosynthetic process (GO:0042759)2.46756325
56stress fiber assembly (GO:0043149)2.46661165
57central nervous system neuron axonogenesis (GO:0021955)2.46592643
58negative regulation of neurotransmitter secretion (GO:0046929)2.45372289
59regulation of cardioblast differentiation (GO:0051890)2.45189849
60regulation of growth hormone secretion (GO:0060123)2.43926301
61fatty acid elongation (GO:0030497)2.43845824
62glomerular filtration (GO:0003094)2.43747789
63renal filtration (GO:0097205)2.42096287
64platelet-derived growth factor receptor signaling pathway (GO:0048008)2.41303026
65myelin assembly (GO:0032288)2.40912400
66negative regulation of axon extension involved in axon guidance (GO:0048843)2.40364866
67import into cell (GO:0098657)2.40180335
68lens fiber cell development (GO:0070307)2.40151190
69nucleobase catabolic process (GO:0046113)2.38563193
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37991496
71negative regulation of neurotransmitter transport (GO:0051589)2.37984379
72cytoplasmic mRNA processing body assembly (GO:0033962)2.37813085
73regulation of transforming growth factor beta2 production (GO:0032909)2.36258917
74SMAD protein complex assembly (GO:0007183)2.35713223
75inner ear receptor cell development (GO:0060119)2.35370821
76cranial suture morphogenesis (GO:0060363)2.35333932
77establishment of tissue polarity (GO:0007164)2.35268833
78establishment of planar polarity (GO:0001736)2.35268833
79axonal fasciculation (GO:0007413)2.34924686
80regulation of Rac protein signal transduction (GO:0035020)2.34277375
81negative regulation of Rho protein signal transduction (GO:0035024)2.33413728
82gastrulation with mouth forming second (GO:0001702)2.33325969
83ganglion development (GO:0061548)2.33151746
84nucleus localization (GO:0051647)2.32987150
85regulation of axon extension involved in axon guidance (GO:0048841)2.31429774
86regulation of non-canonical Wnt signaling pathway (GO:2000050)2.31379239
87regulation of catenin import into nucleus (GO:0035412)2.31335003
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.31117136
89negative regulation of keratinocyte proliferation (GO:0010839)2.30628009
90regulation of integrin-mediated signaling pathway (GO:2001044)2.29825880
91chondrocyte development (GO:0002063)2.29763066
92negative regulation of chondrocyte differentiation (GO:0032331)2.28896893
93organelle transport along microtubule (GO:0072384)2.27932619
94fibroblast migration (GO:0010761)2.26471795
95positive regulation of catenin import into nucleus (GO:0035413)2.26104190
96positive regulation of osteoblast proliferation (GO:0033690)2.25502132
97retinal ganglion cell axon guidance (GO:0031290)2.24719021
98lymphangiogenesis (GO:0001946)2.23705376
99olfactory bulb development (GO:0021772)2.23109403
100vascular endothelial growth factor signaling pathway (GO:0038084)2.22402465
101axis elongation (GO:0003401)2.22259361
102branch elongation of an epithelium (GO:0060602)2.21990788
103trabecula formation (GO:0060343)2.21205193
104axon extension involved in axon guidance (GO:0048846)2.20892310
105neuron projection extension involved in neuron projection guidance (GO:1902284)2.20892310
106membrane assembly (GO:0071709)2.20215274
107lung-associated mesenchyme development (GO:0060484)2.19653002
108nerve growth factor signaling pathway (GO:0038180)2.19401482
109blood vessel maturation (GO:0001955)2.19393885
110pathway-restricted SMAD protein phosphorylation (GO:0060389)2.18973565
111cell adhesion mediated by integrin (GO:0033627)2.18897062
112neural tube formation (GO:0001841)2.18666086
113limb development (GO:0060173)2.18660805
114appendage development (GO:0048736)2.18660805
115heart trabecula formation (GO:0060347)2.18324781
116positive regulation of amino acid transport (GO:0051957)2.18281977
117mitotic cytokinesis (GO:0000281)2.18134064
118intraciliary transport (GO:0042073)2.17616832
119positive regulation of cardiac muscle cell differentiation (GO:2000727)2.17514515
120neural crest cell development (GO:0014032)2.17429297
121regulation of pigment cell differentiation (GO:0050932)2.17243001
122cardiac myofibril assembly (GO:0055003)2.16577144
123cell migration involved in sprouting angiogenesis (GO:0002042)2.15852387
124kidney mesenchyme development (GO:0072074)2.15439850
125regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.14355115
126astrocyte development (GO:0014002)2.14290798
127prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.14064518
128body morphogenesis (GO:0010171)2.13956132
129branching involved in prostate gland morphogenesis (GO:0060442)2.13422184
130ephrin receptor signaling pathway (GO:0048013)2.13220107
131magnesium ion transport (GO:0015693)2.13191841
132positive regulation of dendritic spine morphogenesis (GO:0061003)2.13001089
133peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.12563938
134dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.12427359
135mesenchymal-epithelial cell signaling (GO:0060638)2.12116589
136neuron projection extension (GO:1990138)2.11733259
137postsynaptic membrane organization (GO:0001941)2.11461402
138neuromuscular junction development (GO:0007528)2.11031877
139adherens junction assembly (GO:0034333)2.10618284
140behavioral response to ethanol (GO:0048149)2.10512117
141positive regulation of Rho protein signal transduction (GO:0035025)2.09786968
142regulation of osteoblast proliferation (GO:0033688)2.08981090
143smooth muscle tissue development (GO:0048745)2.08678400
144pericardium development (GO:0060039)2.08587099
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.07946673
146acrosome assembly (GO:0001675)2.07938804
147negative regulation of adherens junction organization (GO:1903392)2.07688083
148negative regulation of focal adhesion assembly (GO:0051895)2.07688083
149negative regulation of cell junction assembly (GO:1901889)2.07688083
150regulation of adherens junction organization (GO:1903391)2.07501222
151sympathetic nervous system development (GO:0048485)2.06993518
152embryonic body morphogenesis (GO:0010172)2.06933161
153regulation of focal adhesion assembly (GO:0051893)2.06797969
154regulation of cell-substrate junction assembly (GO:0090109)2.06797969
155cardiac epithelial to mesenchymal transition (GO:0060317)2.06694333
156heart morphogenesis (GO:0003007)2.06018381
157regulation of axon guidance (GO:1902667)2.06002384
158protein targeting to plasma membrane (GO:0072661)2.05336411
159regulation of keratinocyte proliferation (GO:0010837)2.05332730
160cell proliferation in forebrain (GO:0021846)2.04820472
161regulation of hippo signaling (GO:0035330)2.02628711
162regulation of establishment of planar polarity (GO:0090175)2.01902155
163establishment of protein localization to Golgi (GO:0072600)2.01304137
164positive regulation of male gonad development (GO:2000020)2.01303380
165monoubiquitinated protein deubiquitination (GO:0035520)2.01070727
166face morphogenesis (GO:0060325)2.01025131
167metanephric mesenchyme development (GO:0072075)2.00559929
168positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)1.99322142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.67597273
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.64662612
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40050004
4TAF15_26573619_Chip-Seq_HEK293_Human2.24639060
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.23235634
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17013824
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15311749
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10792236
9IGF1R_20145208_ChIP-Seq_DFB_Human2.08479473
10WT1_19549856_ChIP-ChIP_CCG9911_Human1.97253422
11TP53_16413492_ChIP-PET_HCT116_Human1.96427733
12SALL1_21062744_ChIP-ChIP_HESCs_Human1.96221877
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95340302
14* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94556452
15SMAD_19615063_ChIP-ChIP_OVARY_Human1.86293874
16AR_21572438_ChIP-Seq_LNCaP_Human1.84940837
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84507190
18* GBX2_23144817_ChIP-Seq_PC3_Human1.83918375
19* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83391453
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82556736
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82309385
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81570998
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80147013
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79976419
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77002230
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76837595
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.73924322
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69765884
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69212471
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.67739446
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.66408076
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65696014
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65400959
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65400959
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63304096
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63304096
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55710847
38FUS_26573619_Chip-Seq_HEK293_Human1.55384760
39* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51405911
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49602579
41CJUN_26792858_Chip-Seq_BT549_Human1.48580135
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48291151
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46648937
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45703959
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45666558
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.44415136
47CLOCK_20551151_ChIP-Seq_293T_Human1.44020867
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43105988
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42574077
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42432519
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42349706
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.42186327
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41753147
54EZH2_22144423_ChIP-Seq_EOC_Human1.41284672
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39525928
56* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38994857
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36511155
58TCF4_23295773_ChIP-Seq_U87_Human1.36061637
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34932537
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.34571784
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33661991
62AR_25329375_ChIP-Seq_VCAP_Human1.32638004
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32464236
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.32284584
65BRD4_25478319_ChIP-Seq_HGPS_Human1.32279424
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.32091274
67RNF2_27304074_Chip-Seq_NSC_Mouse1.31968869
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31945644
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.31790335
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.31275543
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30478962
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29170216
73STAT3_23295773_ChIP-Seq_U87_Human1.28203237
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.28029216
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.27802890
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27773206
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26855795
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24560994
79TP53_18474530_ChIP-ChIP_U2OS_Human1.23519059
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23307192
81EWS_26573619_Chip-Seq_HEK293_Human1.23294647
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23194946
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22795357
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22765303
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21680115
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.21168504
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.20913488
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20184538
89P53_22387025_ChIP-Seq_ESCs_Mouse1.19159594
90VDR_22108803_ChIP-Seq_LS180_Human1.18082148
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17603383
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17275930
93RUNX2_22187159_ChIP-Seq_PCA_Human1.16988086
94SMAD4_21799915_ChIP-Seq_A2780_Human1.16022934
95PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14516594
96AHR_22903824_ChIP-Seq_MCF-7_Human1.14480800
97SOX9_26525672_Chip-Seq_HEART_Mouse1.13979976
98RXR_22108803_ChIP-Seq_LS180_Human1.13880070
99JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13673963
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12975072
101CBP_20019798_ChIP-Seq_JUKART_Human1.12975072
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.12582848
103KDM2B_26808549_Chip-Seq_REH_Human1.12413178
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.12039380
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11010467
106* FLI1_21867929_ChIP-Seq_TH2_Mouse1.10824890
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10519465
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08956448
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.08360195
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07643458
111P300_19829295_ChIP-Seq_ESCs_Human1.07345595
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07239098
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06999621
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06226423
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06176058
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05152022
117TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04762465
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04584371
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04503675
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03776770
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03727699
122TCF4_18268006_ChIP-ChIP_LS174T_Human1.03640060
123ZNF274_21170338_ChIP-Seq_K562_Hela1.03462960
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03198604
125RING1B_27294783_Chip-Seq_NPCs_Mouse1.02828595
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02749429
127SMAD3_21741376_ChIP-Seq_HESCs_Human1.02598130
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02062418
129MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01447186
130TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01345518
131TP63_23658742_ChIP-Seq_EP156T_Human1.00189455
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99471168
133TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98701054
134EZH2_27294783_Chip-Seq_ESCs_Mouse0.98379739
135ER_23166858_ChIP-Seq_MCF-7_Human0.96818367
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95520116
137* AR_19668381_ChIP-Seq_PC3_Human0.94264151
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93193071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.01536026
2MP0004272_abnormal_basement_membrane2.91721124
3MP0005623_abnormal_meninges_morphology2.72244252
4MP0003950_abnormal_plasma_membrane2.70662242
5MP0000569_abnormal_digit_pigmentation2.45008630
6MP0005275_abnormal_skin_tensile2.36634378
7MP0001299_abnormal_eye_distance/2.14479764
8MP0005503_abnormal_tendon_morphology2.13999167
9MP0003705_abnormal_hypodermis_morpholog2.06435922
10MP0000537_abnormal_urethra_morphology2.05724327
11MP0005171_absent_coat_pigmentation1.98070118
12MP0003937_abnormal_limbs/digits/tail_de1.97440837
13MP0003385_abnormal_body_wall1.94727557
14MP0009384_cardiac_valve_regurgitation1.86688291
15MP0009250_abnormal_appendicular_skeleto1.81656642
16MP0010368_abnormal_lymphatic_system1.78072860
17MP0010678_abnormal_skin_adnexa1.73682031
18MP0000920_abnormal_myelination1.64410517
19MP0000049_abnormal_middle_ear1.59691265
20MP0003890_abnormal_embryonic-extraembry1.56088504
21MP0000462_abnormal_digestive_system1.53444410
22MP0003279_aneurysm1.50818045
23MP0006054_spinal_hemorrhage1.50412375
24MP0002234_abnormal_pharynx_morphology1.47898617
25MP0001188_hyperpigmentation1.45145992
26MP0002295_abnormal_pulmonary_circulatio1.44916309
27MP0000733_abnormal_muscle_development1.44755136
28MP0000003_abnormal_adipose_tissue1.43424107
29MP0003880_abnormal_central_pattern1.43352704
30MP0005508_abnormal_skeleton_morphology1.42342319
31MP0001879_abnormal_lymphatic_vessel1.40984997
32MP0004145_abnormal_muscle_electrophysio1.38357926
33MP0000013_abnormal_adipose_tissue1.37337356
34MP0004885_abnormal_endolymph1.36779915
35MP0003755_abnormal_palate_morphology1.34597949
36MP0004084_abnormal_cardiac_muscle1.32492047
37MP0005248_abnormal_Harderian_gland1.31073219
38MP0010352_gastrointestinal_tract_polyps1.29237462
39MP0003091_abnormal_cell_migration1.29148922
40MP0000383_abnormal_hair_follicle1.28144195
41MP0009780_abnormal_chondrocyte_physiolo1.27693750
42MP0000778_abnormal_nervous_system1.27661907
43MP0009697_abnormal_copulation1.27111841
44MP0006276_abnormal_autonomic_nervous1.25940949
45MP0004185_abnormal_adipocyte_glucose1.25899790
46MP0003935_abnormal_craniofacial_develop1.23527709
47MP0006138_congestive_heart_failure1.23095186
48MP0008057_abnormal_DNA_replication1.22446179
49MP0003123_paternal_imprinting1.22296535
50MP0000534_abnormal_ureter_morphology1.22108274
51MP0002938_white_spotting1.21857331
52MP0005257_abnormal_intraocular_pressure1.21789145
53MP0004134_abnormal_chest_morphology1.18983519
54MP0004859_abnormal_synaptic_plasticity1.18685187
55MP0000428_abnormal_craniofacial_morphol1.18613812
56MP0000767_abnormal_smooth_muscle1.18324480
57MP0000427_abnormal_hair_cycle1.17334024
58MP0003115_abnormal_respiratory_system1.17054672
59MP0004270_analgesia1.16235193
60MP0001286_abnormal_eye_development1.14014265
61MP0001958_emphysema1.13645127
62MP0004036_abnormal_muscle_relaxation1.13553001
63MP0002751_abnormal_autonomic_nervous1.13311381
64MP0002282_abnormal_trachea_morphology1.11715896
65MP0002108_abnormal_muscle_morphology1.11691723
66MP0003942_abnormal_urinary_system1.11416499
67MP0005187_abnormal_penis_morphology1.10645927
68MP0003941_abnormal_skin_development1.10616958
69MP0001177_atelectasis1.09181541
70MP0010030_abnormal_orbit_morphology1.08365719
71MP0002932_abnormal_joint_morphology1.08212222
72MP0009053_abnormal_anal_canal1.08052275
73MP0003121_genomic_imprinting1.05844202
74MP0002177_abnormal_outer_ear1.04347521
75MP0002109_abnormal_limb_morphology1.02983551
76MP0000747_muscle_weakness1.02925661
77MP0000762_abnormal_tongue_morphology1.02411140
78MP0008789_abnormal_olfactory_epithelium1.00838618
79MP0002925_abnormal_cardiovascular_devel0.99825025
80MP0000432_abnormal_head_morphology0.99612999
81MP0000647_abnormal_sebaceous_gland0.99138127
82MP0010386_abnormal_urinary_bladder0.99137301
83MP0002184_abnormal_innervation0.98398482
84MP0001346_abnormal_lacrimal_gland0.97598174
85MP0000631_abnormal_neuroendocrine_gland0.95885806
86MP0003122_maternal_imprinting0.95665631
87MP0004215_abnormal_myocardial_fiber0.95044268
88MP0005620_abnormal_muscle_contractility0.94839923
89MP0002092_abnormal_eye_morphology0.94167081
90MP0005595_abnormal_vascular_smooth0.94013360
91MP0003656_abnormal_erythrocyte_physiolo0.93887921
92MP0003566_abnormal_cell_adhesion0.92484669
93MP0000566_synostosis0.90814290
94MP0004087_abnormal_muscle_fiber0.90581624
95MP0002009_preneoplasia0.89073759
96MP0001293_anophthalmia0.87797268
97MP0002081_perinatal_lethality0.87343422
98MP0002115_abnormal_skeleton_extremities0.86954580
99MP0002233_abnormal_nose_morphology0.86474521
100MP0002084_abnormal_developmental_patter0.86212951
101MP0003634_abnormal_glial_cell0.86043090
102MP0002116_abnormal_craniofacial_bone0.85913652
103MP0000751_myopathy0.85345038
104MP0005394_taste/olfaction_phenotype0.85313816
105MP0005499_abnormal_olfactory_system0.85313816
106MP0002102_abnormal_ear_morphology0.85095451
107MP0002896_abnormal_bone_mineralization0.84963483
108MP0002972_abnormal_cardiac_muscle0.84395873
109MP0003329_amyloid_beta_deposits0.84314737
110MP0000749_muscle_degeneration0.83495313
111MP0001614_abnormal_blood_vessel0.83331009
112MP0003861_abnormal_nervous_system0.83320546
113MP0002697_abnormal_eye_size0.82841064
114MP0004811_abnormal_neuron_physiology0.82444643
115MP0000955_abnormal_spinal_cord0.82401262
116MP0000579_abnormal_nail_morphology0.82032775
117MP0002877_abnormal_melanocyte_morpholog0.81137931
118MP0005367_renal/urinary_system_phenotyp0.81137862
119MP0000516_abnormal_urinary_system0.81137862
120MP0002128_abnormal_blood_circulation0.81040819
121MP0003119_abnormal_digestive_system0.80903365
122MP0003787_abnormal_imprinting0.80783350
123MP0002160_abnormal_reproductive_system0.80437197
124MP0003632_abnormal_nervous_system0.80332990
125MP0001529_abnormal_vocalization0.80255100
126MP0002152_abnormal_brain_morphology0.79859446
127MP0010234_abnormal_vibrissa_follicle0.79812495
128MP0001340_abnormal_eyelid_morphology0.79684909
129MP0001784_abnormal_fluid_regulation0.78405827
130MP0002249_abnormal_larynx_morphology0.78169541
131MP0005391_vision/eye_phenotype0.78023102
132MP0002114_abnormal_axial_skeleton0.77931436
133MP0004484_altered_response_of0.77113386
134MP0000163_abnormal_cartilage_morphology0.76951245
135MP0008775_abnormal_heart_ventricle0.76945148
136MP0005388_respiratory_system_phenotype0.75721852
137MP0002133_abnormal_respiratory_system0.75721852
138MP0002882_abnormal_neuron_morphology0.74325369
139MP0005195_abnormal_posterior_eye0.73649640

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.59775476
2Protrusio acetabuli (HP:0003179)3.70864892
3Shallow orbits (HP:0000586)3.60724353
4Degeneration of the lateral corticospinal tracts (HP:0002314)2.99591634
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.99591634
6Aplasia involving bones of the upper limbs (HP:0009823)2.99248462
7Aplasia of the phalanges of the hand (HP:0009802)2.99248462
8Aplasia involving bones of the extremities (HP:0009825)2.99248462
9Papillary thyroid carcinoma (HP:0002895)2.98397375
10Broad metatarsal (HP:0001783)2.90159087
11Buphthalmos (HP:0000557)2.78529863
12Bell-shaped thorax (HP:0001591)2.73053325
13Aortic dissection (HP:0002647)2.72680043
14Neonatal short-limb short stature (HP:0008921)2.72464790
15Termporal pattern (HP:0011008)2.67098831
16Insidious onset (HP:0003587)2.67098831
17Muscle fiber splitting (HP:0003555)2.59067126
18Coronal craniosynostosis (HP:0004440)2.51411649
19Vascular tortuosity (HP:0004948)2.49917372
20Arterial tortuosity (HP:0005116)2.49464339
21Neurofibrillary tangles (HP:0002185)2.48570633
22Soft skin (HP:0000977)2.42584460
23Hypoplastic ischia (HP:0003175)2.41050943
24Infantile muscular hypotonia (HP:0008947)2.36974455
25Cerebral inclusion bodies (HP:0100314)2.34331127
26Short hallux (HP:0010109)2.31245910
27Atrophic scars (HP:0001075)2.28396767
28Bladder diverticulum (HP:0000015)2.24449646
29Drooling (HP:0002307)2.24078619
30Ankle contracture (HP:0006466)2.22844048
31Scapular winging (HP:0003691)2.21436934
32Aortic aneurysm (HP:0004942)2.20207709
33Abnormality of the ischium (HP:0003174)2.19674713
34Abnormality of the corticospinal tract (HP:0002492)2.19546820
35Cerebral aneurysm (HP:0004944)2.18805597
36Abnormality of dentin (HP:0010299)2.15045930
37Overgrowth (HP:0001548)2.13079893
38Megalencephaly (HP:0001355)2.12350469
39Mitral valve prolapse (HP:0001634)2.10687564
40Volvulus (HP:0002580)2.09197668
41Vertebral arch anomaly (HP:0008438)2.08407166
42Myelomeningocele (HP:0002475)2.06949983
43Hyperextensible skin (HP:0000974)2.06487996
44Aplasia/Hypoplasia of the hallux (HP:0008362)2.05129179
45Microglossia (HP:0000171)2.04474989
46Spinal rigidity (HP:0003306)2.04165522
47Hypoplasia of the iris (HP:0007676)2.01708486
48Hyporeflexia of lower limbs (HP:0002600)2.00512275
49Absent frontal sinuses (HP:0002688)2.00422076
50Protruding tongue (HP:0010808)1.98375009
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98178490
52Thyroid carcinoma (HP:0002890)1.97816366
53Thickened helices (HP:0000391)1.95933778
54Heterotopia (HP:0002282)1.94332236
55Limited hip movement (HP:0008800)1.94240532
56Hyperventilation (HP:0002883)1.92975943
57Broad ribs (HP:0000885)1.92667668
58Excessive salivation (HP:0003781)1.90060204
59Abnormality of the antihelix (HP:0009738)1.88629872
60Peritonitis (HP:0002586)1.88555076
61Preaxial foot polydactyly (HP:0001841)1.87663119
62Bronchomalacia (HP:0002780)1.86014296
63Fibular aplasia (HP:0002990)1.85897050
64Mild short stature (HP:0003502)1.85185651
65Abnormality of the phalanges of the hallux (HP:0010057)1.85045374
66Wrist flexion contracture (HP:0001239)1.83425985
67Wormian bones (HP:0002645)1.83163863
68Aortic regurgitation (HP:0001659)1.82930362
69Broad distal phalanx of finger (HP:0009836)1.82745666
70Intellectual disability, moderate (HP:0002342)1.82579588
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.81475663
72Round ear (HP:0100830)1.80884514
73Pancreatic fibrosis (HP:0100732)1.80830345
74Pulmonic stenosis (HP:0001642)1.80586438
75Bowel diverticulosis (HP:0005222)1.80478202
76Cutaneous finger syndactyly (HP:0010554)1.78093543
77Relative macrocephaly (HP:0004482)1.77212087
78Morphological abnormality of the middle ear (HP:0008609)1.76879470
79Cubitus valgus (HP:0002967)1.74892527
80Absent speech (HP:0001344)1.73394525
81Broad long bones (HP:0005622)1.72874407
82Wide anterior fontanel (HP:0000260)1.72788670
83Increased mean platelet volume (HP:0011877)1.71382465
84Hypoplastic labia majora (HP:0000059)1.71056084
85Dilatation of the ascending aorta (HP:0005111)1.70505149
86Type 1 muscle fiber predominance (HP:0003803)1.70399829
87Anteriorly placed anus (HP:0001545)1.70394229
88Blue sclerae (HP:0000592)1.70307300
89Ulnar bowing (HP:0003031)1.69562709
90Deviation of the hallux (HP:0010051)1.68728814
91Nephronophthisis (HP:0000090)1.68521871
92Asymmetry of the thorax (HP:0001555)1.68399935
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68162614
94Follicular hyperkeratosis (HP:0007502)1.67214890
95Congenital glaucoma (HP:0001087)1.67063630
96Abnormality of incisor morphology (HP:0011063)1.65799679
97Esophageal atresia (HP:0002032)1.65488707
98Midline defect of the nose (HP:0004122)1.64943147
99Difficulty running (HP:0009046)1.64601446
100Vitreoretinal degeneration (HP:0000655)1.64399883
101Short 4th metacarpal (HP:0010044)1.63752636
102Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63752636
103Abnormality of the middle phalanges of the toes (HP:0010183)1.63559202
104Genital tract atresia (HP:0001827)1.63467533
105Alacrima (HP:0000522)1.62689189
106Onion bulb formation (HP:0003383)1.62153704
107Postaxial hand polydactyly (HP:0001162)1.61977921
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61631655
109Broad phalanx (HP:0006009)1.61623445
110Transitional cell carcinoma of the bladder (HP:0006740)1.61433051
111Tracheomalacia (HP:0002779)1.60361761
112Hallux valgus (HP:0001822)1.60310315
113Type II lissencephaly (HP:0007260)1.60193168
114Aplasia/Hypoplasia of the tongue (HP:0010295)1.59917294
115Abnormality of the 2nd finger (HP:0004100)1.59871286
116Postaxial foot polydactyly (HP:0001830)1.59792571
117Genu recurvatum (HP:0002816)1.59775082
118Abnormality of midbrain morphology (HP:0002418)1.59605541
119Molar tooth sign on MRI (HP:0002419)1.59605541
120Hammertoe (HP:0001765)1.59459350
121Abnormality of the renal medulla (HP:0100957)1.59088366
122Short foot (HP:0001773)1.57215853
123Increased variability in muscle fiber diameter (HP:0003557)1.57139152
124Hip contracture (HP:0003273)1.56303631
125Chronic hepatic failure (HP:0100626)1.56095334
126Abnormality of the proximal phalanges of the hand (HP:0009834)1.55719976
127Bladder carcinoma (HP:0002862)1.55326264
128Bladder neoplasm (HP:0009725)1.55326264
129Broad-based gait (HP:0002136)1.55062090
130Absent eyelashes (HP:0000561)1.54544161
131Abnormality of the shoulder girdle musculature (HP:0001435)1.54329650
132Hepatoblastoma (HP:0002884)1.53930237
133Aneurysm (HP:0002617)1.53909662
134Hypoplastic iliac wings (HP:0002866)1.53509712
135Chorioretinal atrophy (HP:0000533)1.53117362
136Tarsal synostosis (HP:0008368)1.53045608
137True hermaphroditism (HP:0010459)1.52829629
138Medial flaring of the eyebrow (HP:0010747)1.52806328
139Abnormal auditory evoked potentials (HP:0006958)1.52347917
140Exotropia (HP:0000577)1.52034029
141Abnormality of the labia majora (HP:0012881)1.51565180
142Knee flexion contracture (HP:0006380)1.51560724
143Premature skin wrinkling (HP:0100678)1.50998219
144Narrow palate (HP:0000189)1.50845004
145Round face (HP:0000311)1.50307614
146Turricephaly (HP:0000262)1.50232604
147Aqueductal stenosis (HP:0002410)1.49967720
148Fragile skin (HP:0001030)1.49792337
149Cutaneous syndactyly (HP:0012725)1.49692888
150Abnormality of the 4th metacarpal (HP:0010012)1.49680273
151Intestinal atresia (HP:0011100)1.49271754
152Macroorchidism (HP:0000053)1.49086422
153Gait imbalance (HP:0002141)1.48076815
154Hip dysplasia (HP:0001385)1.46880835
155Pachygyria (HP:0001302)1.45704880
156Vaginal atresia (HP:0000148)1.45600328
157Mesomelia (HP:0003027)1.44865557
158Short tibia (HP:0005736)1.44479459
159Abnormality of the lower motor neuron (HP:0002366)1.43926370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.32023336
2CASK3.34547272
3STK392.75444840
4MAP3K42.67198387
5FGFR22.54854515
6TNIK2.41656376
7DDR22.38513358
8MET2.29370405
9LATS22.24795183
10ERBB32.17748563
11PRKD32.05731436
12PDGFRA1.92658763
13DMPK1.88668506
14EPHA41.84864917
15TTN1.79484395
16BRSK21.78148342
17MKNK21.71010694
18TYRO31.59615851
19PAK31.57895878
20STK31.55597294
21EPHB11.51884000
22PTK2B1.51819442
23WNK11.46045678
24BCR1.43880477
25FER1.41607722
26NUAK11.41197785
27MOS1.39125699
28AKT31.38413253
29MAP2K71.37971714
30PDGFRB1.36954599
31MYLK1.34405585
32PTK21.34244293
33TESK21.32951734
34TIE11.32304624
35CAMK1G1.29530582
36PAK61.28846743
37OXSR11.28750933
38MKNK11.25529037
39CSNK1A1L1.24640505
40STK38L1.22312046
41BRD41.20400025
42WEE11.18100512
43EIF2AK31.16916348
44PNCK1.16167993
45BMPR1B1.16155012
46MAP4K21.11084626
47MAPKAPK51.10786720
48KSR11.10084961
49PAK21.09820082
50WNK41.08351529
51PKN11.07873924
52NTRK11.07153084
53TAF11.07062388
54LIMK11.06883636
55SGK21.06363531
56KSR21.05922659
57EPHA31.03942558
58RPS6KA41.03835913
59DYRK31.01931699
60CAMK1D0.98987030
61NTRK20.98311395
62CSNK1G20.96355998
63SGK4940.95823638
64SGK2230.95823638
65MAP3K60.95161441
66ROCK20.94913432
67FRK0.94595844
68MELK0.93521931
69PIK3CA0.93380277
70FGFR10.92433407
71TRIM280.91742464
72RET0.90089740
73PLK20.89499173
74BMX0.87907094
75ERBB40.85734815
76NEK90.85274523
77NTRK30.83641899
78EPHB20.83389197
79CSNK1G10.82490147
80MINK10.81256662
81CCNB10.80971412
82GRK10.80891200
83CSNK1G30.80560940
84PLK40.80012741
85TGFBR10.79046688
86MAP3K20.78014318
87NEK60.77630470
88CDC70.76983715
89PRKD10.75911586
90TRPM70.75701330
91FGR0.75621038
92WNK30.74602035
93MTOR0.74293510
94ROCK10.73156318
95STK240.72047002
96SGK30.69022018
97CDK120.68696065
98PKN20.66396831
99KDR0.66213927
100CDK80.64705987
101MARK10.62438008
102CHEK20.61210942
103PTK60.61112541
104TGFBR20.59622329
105PLK30.59272670
106PRKD20.57083627
107STK380.56611700
108PRKCH0.55788394
109MAP3K90.55684769
110OBSCN0.55332967
111CSNK1D0.53891993
112CAMK2B0.53557718
113BCKDK0.53046950
114PRKCE0.52832226
115DYRK1A0.51807363
116MARK20.51379629
117CAMK2A0.51010270
118PHKG10.50857436
119PHKG20.50857436
120MAPK130.50755668
121CAMK2D0.49604533
122ERBB20.49360136
123FLT30.47437963
124DYRK20.46879290
125TTK0.46872995
126CDK30.45557723
127INSR0.45510078
128BMPR20.45500507
129CDK90.45347910
130NLK0.45308628
131ATM0.45239947
132YES10.43716733
133CDK50.43503754
134CDK140.43446970
135STK100.43359373
136ADRBK10.42929786
137MAP2K10.42687305
138PRKAA10.41880088
139SGK10.40950617
140CAMKK20.40805137
141MAPK100.40550644
142UHMK10.39974793
143GSK3A0.39818294
144PRKACB0.37979447
145PRKCG0.37705375
146CSNK1E0.36600964

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.56118125
2ECM-receptor interaction_Homo sapiens_hsa045122.35784234
3Nitrogen metabolism_Homo sapiens_hsa009102.04110279
4Focal adhesion_Homo sapiens_hsa045101.96172110
5Hippo signaling pathway_Homo sapiens_hsa043901.93490128
6Tight junction_Homo sapiens_hsa045301.89526388
7Axon guidance_Homo sapiens_hsa043601.87978678
8Adherens junction_Homo sapiens_hsa045201.87081885
9Renal cell carcinoma_Homo sapiens_hsa052111.81816820
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77019623
11Vitamin B6 metabolism_Homo sapiens_hsa007501.74557764
12TGF-beta signaling pathway_Homo sapiens_hsa043501.68493979
13Hedgehog signaling pathway_Homo sapiens_hsa043401.64638600
14Dilated cardiomyopathy_Homo sapiens_hsa054141.63244654
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.54617487
16Steroid biosynthesis_Homo sapiens_hsa001001.53121241
17MicroRNAs in cancer_Homo sapiens_hsa052061.51499202
18Proteoglycans in cancer_Homo sapiens_hsa052051.49334355
19Basal cell carcinoma_Homo sapiens_hsa052171.46101498
20Dorso-ventral axis formation_Homo sapiens_hsa043201.43824809
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43818629
22Ether lipid metabolism_Homo sapiens_hsa005651.43199474
23Nicotine addiction_Homo sapiens_hsa050331.40544690
24Ovarian steroidogenesis_Homo sapiens_hsa049131.25609451
25Wnt signaling pathway_Homo sapiens_hsa043101.22705403
26Glioma_Homo sapiens_hsa052141.22561935
27Gap junction_Homo sapiens_hsa045401.19545133
28Long-term depression_Homo sapiens_hsa047301.19061286
29Glutamatergic synapse_Homo sapiens_hsa047241.17079513
30Melanogenesis_Homo sapiens_hsa049161.16110131
31Rap1 signaling pathway_Homo sapiens_hsa040151.11161157
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09607860
33Lysine degradation_Homo sapiens_hsa003101.09547394
34Small cell lung cancer_Homo sapiens_hsa052221.09095976
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08136995
36Bladder cancer_Homo sapiens_hsa052191.07753563
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05724785
38Prostate cancer_Homo sapiens_hsa052151.05276087
39Fanconi anemia pathway_Homo sapiens_hsa034601.05173615
40ErbB signaling pathway_Homo sapiens_hsa040121.05093066
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04330880
42PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04212858
43Long-term potentiation_Homo sapiens_hsa047201.02793628
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.02502338
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02349390
46Ras signaling pathway_Homo sapiens_hsa040141.01789289
47Platelet activation_Homo sapiens_hsa046111.00642569
48Oxytocin signaling pathway_Homo sapiens_hsa049210.98503232
49Choline metabolism in cancer_Homo sapiens_hsa052310.98189672
50Amoebiasis_Homo sapiens_hsa051460.97471652
51Protein digestion and absorption_Homo sapiens_hsa049740.97408950
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.97253431
53Pancreatic cancer_Homo sapiens_hsa052120.96964338
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96404616
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95471453
56Fatty acid elongation_Homo sapiens_hsa000620.94013626
57GnRH signaling pathway_Homo sapiens_hsa049120.93575929
58Circadian entrainment_Homo sapiens_hsa047130.93076066
59Endometrial cancer_Homo sapiens_hsa052130.92002852
60Oocyte meiosis_Homo sapiens_hsa041140.91924558
61Basal transcription factors_Homo sapiens_hsa030220.91804928
62Dopaminergic synapse_Homo sapiens_hsa047280.90526372
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90445517
64Melanoma_Homo sapiens_hsa052180.90204662
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89963145
66Estrogen signaling pathway_Homo sapiens_hsa049150.89574561
67Serotonergic synapse_Homo sapiens_hsa047260.88652992
68mTOR signaling pathway_Homo sapiens_hsa041500.88186230
69GABAergic synapse_Homo sapiens_hsa047270.85600339
70p53 signaling pathway_Homo sapiens_hsa041150.84969290
71Pathways in cancer_Homo sapiens_hsa052000.84815859
72Cholinergic synapse_Homo sapiens_hsa047250.83626722
73Circadian rhythm_Homo sapiens_hsa047100.81805580
74Olfactory transduction_Homo sapiens_hsa047400.81303704
75Insulin secretion_Homo sapiens_hsa049110.81242279
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79293757
77Taste transduction_Homo sapiens_hsa047420.79060414
78Phototransduction_Homo sapiens_hsa047440.78015606
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76343998
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76305366
81VEGF signaling pathway_Homo sapiens_hsa043700.75136693
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.74765079
83cAMP signaling pathway_Homo sapiens_hsa040240.74591310
84Alcoholism_Homo sapiens_hsa050340.74474818
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.74018953
86Endocytosis_Homo sapiens_hsa041440.73906573
87Inositol phosphate metabolism_Homo sapiens_hsa005620.73445920
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73064948
89Colorectal cancer_Homo sapiens_hsa052100.72685345
90Prolactin signaling pathway_Homo sapiens_hsa049170.72333017
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72316294
92Renin secretion_Homo sapiens_hsa049240.72305334
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71856581
94Thyroid cancer_Homo sapiens_hsa052160.70508589
95Gastric acid secretion_Homo sapiens_hsa049710.70050691
96Calcium signaling pathway_Homo sapiens_hsa040200.69961596
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69275185
98Non-homologous end-joining_Homo sapiens_hsa034500.69017842
99Salivary secretion_Homo sapiens_hsa049700.67716481
100Cocaine addiction_Homo sapiens_hsa050300.67445631
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.67001116
102Chronic myeloid leukemia_Homo sapiens_hsa052200.66710847
103Amphetamine addiction_Homo sapiens_hsa050310.65228176
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65125338
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64555868
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64484211
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63390363
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62492015
109Non-small cell lung cancer_Homo sapiens_hsa052230.61709253
110MAPK signaling pathway_Homo sapiens_hsa040100.61082212
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60247343
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60162538
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58151668
114FoxO signaling pathway_Homo sapiens_hsa040680.57014896
115Cell cycle_Homo sapiens_hsa041100.57013861
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56751172
117AMPK signaling pathway_Homo sapiens_hsa041520.56143980
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55793155
119mRNA surveillance pathway_Homo sapiens_hsa030150.55260527
120Sphingolipid metabolism_Homo sapiens_hsa006000.55070857
121Selenocompound metabolism_Homo sapiens_hsa004500.55002450
122Morphine addiction_Homo sapiens_hsa050320.54812421
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50679090

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »