

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | behavioral response to nicotine (GO:0035095) | 5.38491964 |
| 2 | neuron cell-cell adhesion (GO:0007158) | 5.30680368 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.29652482 |
| 4 | synaptic vesicle maturation (GO:0016188) | 5.25276903 |
| 5 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.08651215 |
| 6 | vocalization behavior (GO:0071625) | 4.99546932 |
| 7 | layer formation in cerebral cortex (GO:0021819) | 4.97883710 |
| 8 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.90890116 |
| 9 | protein localization to synapse (GO:0035418) | 4.84035860 |
| 10 | synaptic vesicle exocytosis (GO:0016079) | 4.82998444 |
| 11 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.71121695 |
| 12 | locomotory exploration behavior (GO:0035641) | 4.69039220 |
| 13 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.66986566 |
| 14 | response to pheromone (GO:0019236) | 4.65403981 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.52928027 |
| 16 | glutamate secretion (GO:0014047) | 4.49268646 |
| 17 | regulation of synapse structural plasticity (GO:0051823) | 4.42396609 |
| 18 | dendritic spine morphogenesis (GO:0060997) | 4.40563925 |
| 19 | neuron recognition (GO:0008038) | 4.38470172 |
| 20 | axonal fasciculation (GO:0007413) | 4.31342338 |
| 21 | cell migration in hindbrain (GO:0021535) | 4.20243596 |
| 22 | exploration behavior (GO:0035640) | 4.17585685 |
| 23 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.13824000 |
| 24 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.94941875 |
| 25 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.94941875 |
| 26 | nucleobase catabolic process (GO:0046113) | 3.92386551 |
| 27 | negative regulation of microtubule polymerization (GO:0031115) | 3.92233213 |
| 28 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.91799634 |
| 29 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.91634016 |
| 30 | regulation of synaptic vesicle transport (GO:1902803) | 3.89256749 |
| 31 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.88469196 |
| 32 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.83494603 |
| 33 | neurotransmitter secretion (GO:0007269) | 3.76466635 |
| 34 | * dendrite morphogenesis (GO:0048813) | 3.75898096 |
| 35 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.74208119 |
| 36 | positive regulation of synapse maturation (GO:0090129) | 3.73914361 |
| 37 | neurofilament cytoskeleton organization (GO:0060052) | 3.73262872 |
| 38 | postsynaptic membrane organization (GO:0001941) | 3.72151370 |
| 39 | retinal ganglion cell axon guidance (GO:0031290) | 3.71457128 |
| 40 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.69670390 |
| 41 | epithelial cilium movement (GO:0003351) | 3.63875608 |
| 42 | axonemal dynein complex assembly (GO:0070286) | 3.63443273 |
| 43 | proline transport (GO:0015824) | 3.62040800 |
| 44 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.58168897 |
| 45 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.53950673 |
| 46 | glutamate receptor signaling pathway (GO:0007215) | 3.47345757 |
| 47 | establishment of mitochondrion localization (GO:0051654) | 3.46162114 |
| 48 | mechanosensory behavior (GO:0007638) | 3.43237535 |
| 49 | synaptic transmission, glutamatergic (GO:0035249) | 3.40719933 |
| 50 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.39770825 |
| 51 | mitochondrion transport along microtubule (GO:0047497) | 3.39770825 |
| 52 | cilium movement (GO:0003341) | 3.36199615 |
| 53 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.34073464 |
| 54 | cellular potassium ion homeostasis (GO:0030007) | 3.31261457 |
| 55 | synapse assembly (GO:0007416) | 3.29655731 |
| 56 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.28968177 |
| 57 | neuronal action potential propagation (GO:0019227) | 3.28734811 |
| 58 | neuron-neuron synaptic transmission (GO:0007270) | 3.26903889 |
| 59 | positive regulation of gastrulation (GO:2000543) | 3.25326183 |
| 60 | forebrain neuron differentiation (GO:0021879) | 3.25317150 |
| 61 | axon extension (GO:0048675) | 3.24681971 |
| 62 | auditory behavior (GO:0031223) | 3.24524668 |
| 63 | axon cargo transport (GO:0008088) | 3.24486713 |
| 64 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.20237111 |
| 65 | adult walking behavior (GO:0007628) | 3.20026835 |
| 66 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.18882229 |
| 67 | response to auditory stimulus (GO:0010996) | 3.17822417 |
| 68 | positive regulation of synapse assembly (GO:0051965) | 3.12620308 |
| 69 | positive regulation of membrane potential (GO:0045838) | 3.12328504 |
| 70 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.12261549 |
| 71 | axon ensheathment in central nervous system (GO:0032291) | 3.12067183 |
| 72 | central nervous system myelination (GO:0022010) | 3.12067183 |
| 73 | transmission of nerve impulse (GO:0019226) | 3.11969330 |
| 74 | regulation of neurotransmitter secretion (GO:0046928) | 3.11591274 |
| 75 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.10708261 |
| 76 | synaptic vesicle endocytosis (GO:0048488) | 3.10674244 |
| 77 | organelle transport along microtubule (GO:0072384) | 3.10301214 |
| 78 | spinal cord association neuron differentiation (GO:0021527) | 3.10046883 |
| 79 | positive regulation of dendritic spine development (GO:0060999) | 3.09094460 |
| 80 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.08803845 |
| 81 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.08669930 |
| 82 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.08093817 |
| 83 | spinal cord development (GO:0021510) | 3.07770869 |
| 84 | innervation (GO:0060384) | 3.07567466 |
| 85 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.07509721 |
| 86 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.06275201 |
| 87 | central nervous system neuron axonogenesis (GO:0021955) | 3.05952982 |
| 88 | neurotransmitter transport (GO:0006836) | 3.05037224 |
| 89 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.04983581 |
| 90 | regulation of postsynaptic membrane potential (GO:0060078) | 3.04670088 |
| 91 | gamma-aminobutyric acid transport (GO:0015812) | 3.03118639 |
| 92 | membrane hyperpolarization (GO:0060081) | 3.02420361 |
| 93 | neuronal ion channel clustering (GO:0045161) | 3.01436385 |
| 94 | activation of protein kinase A activity (GO:0034199) | 3.00602348 |
| 95 | presynaptic membrane assembly (GO:0097105) | 3.00455882 |
| 96 | regulation of vesicle fusion (GO:0031338) | 3.00151497 |
| 97 | long-term memory (GO:0007616) | 2.97834321 |
| 98 | mating behavior (GO:0007617) | 2.96538598 |
| 99 | negative regulation of axon guidance (GO:1902668) | 2.95431258 |
| 100 | synapse organization (GO:0050808) | 2.93959690 |
| 101 | presynaptic membrane organization (GO:0097090) | 2.93577028 |
| 102 | neuromuscular process controlling balance (GO:0050885) | 2.93323005 |
| 103 | regulation of microtubule-based movement (GO:0060632) | 2.91964699 |
| 104 | regulation of synapse maturation (GO:0090128) | 2.91212957 |
| 105 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.90685871 |
| 106 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.90191015 |
| 107 | neuron projection extension (GO:1990138) | 2.89474700 |
| 108 | short-term memory (GO:0007614) | 2.88967493 |
| 109 | cell communication by electrical coupling (GO:0010644) | 2.87930884 |
| 110 | dendritic spine organization (GO:0097061) | 2.87121022 |
| 111 | synaptic transmission, cholinergic (GO:0007271) | 2.87054066 |
| 112 | clathrin coat assembly (GO:0048268) | 2.84717433 |
| 113 | regulation of axon guidance (GO:1902667) | 2.84068843 |
| 114 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.83660814 |
| 115 | axon extension involved in axon guidance (GO:0048846) | 2.83428470 |
| 116 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.83428470 |
| 117 | regulation of synaptic plasticity (GO:0048167) | 2.83068734 |
| 118 | regulation of axon extension (GO:0030516) | 2.82970740 |
| 119 | cerebellar Purkinje cell layer development (GO:0021680) | 2.82533828 |
| 120 | positive regulation of axon extension (GO:0045773) | 2.82311957 |
| 121 | cerebellar granule cell differentiation (GO:0021707) | 2.82300741 |
| 122 | regulation of cilium movement (GO:0003352) | 2.81868084 |
| 123 | negative regulation of axon extension (GO:0030517) | 2.81786561 |
| 124 | regulation of neurotransmitter transport (GO:0051588) | 2.81779723 |
| 125 | neuromuscular synaptic transmission (GO:0007274) | 2.81525478 |
| 126 | negative regulation of axonogenesis (GO:0050771) | 2.81298875 |
| 127 | neuron migration (GO:0001764) | 2.81095611 |
| 128 | learning (GO:0007612) | 2.80953412 |
| 129 | cell differentiation in hindbrain (GO:0021533) | 2.80736277 |
| 130 | prepulse inhibition (GO:0060134) | 2.80464942 |
| 131 | nonmotile primary cilium assembly (GO:0035058) | 2.80217679 |
| 132 | dopamine receptor signaling pathway (GO:0007212) | 2.80118250 |
| 133 | dendrite development (GO:0016358) | 2.79979639 |
| 134 | cell proliferation in forebrain (GO:0021846) | 2.78048184 |
| 135 | intraciliary transport (GO:0042073) | 2.76777622 |
| 136 | protein localization to cilium (GO:0061512) | 2.71904987 |
| 137 | left/right pattern formation (GO:0060972) | 2.69274817 |
| 138 | regulation of synapse assembly (GO:0051963) | 2.68523001 |
| 139 | regulation of respiratory system process (GO:0044065) | 2.64808883 |
| 140 | membrane depolarization during action potential (GO:0086010) | 2.63953158 |
| 141 | neuron maturation (GO:0042551) | 2.61643121 |
| 142 | camera-type eye morphogenesis (GO:0048593) | 2.58280033 |
| 143 | body morphogenesis (GO:0010171) | 2.57394966 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.72075930 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.44478609 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.09299813 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.07751708 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.94834844 |
| 6 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.77174261 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.76801485 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.76801485 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.72749002 |
| 10 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.64364283 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.61933192 |
| 12 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.57975402 |
| 13 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.56695286 |
| 14 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.50783201 |
| 15 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.48730673 |
| 16 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.47366544 |
| 17 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.45901239 |
| 18 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.45218541 |
| 19 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.44863235 |
| 20 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.44315051 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.40007459 |
| 22 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.37699412 |
| 23 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.28182185 |
| 24 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.27664523 |
| 25 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.26777716 |
| 26 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.21620384 |
| 27 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.15644982 |
| 28 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.11596006 |
| 29 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.09122343 |
| 30 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.05997919 |
| 31 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.04167851 |
| 32 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.93710620 |
| 33 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.81269052 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.71033762 |
| 35 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.62255565 |
| 36 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.61531538 |
| 37 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.61005871 |
| 38 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.59263198 |
| 39 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.57863497 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.52391563 |
| 41 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.52000826 |
| 42 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.51729780 |
| 43 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.48572897 |
| 44 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.47639229 |
| 45 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.46715943 |
| 46 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.43757959 |
| 47 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.42598933 |
| 48 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.41403365 |
| 49 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.40330949 |
| 50 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.40069556 |
| 51 | VDR_22108803_ChIP-Seq_LS180_Human | 1.37468021 |
| 52 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.31114327 |
| 53 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.28028100 |
| 54 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.26396236 |
| 55 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.24578332 |
| 56 | P300_19829295_ChIP-Seq_ESCs_Human | 1.23065233 |
| 57 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.22590031 |
| 58 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.22390706 |
| 59 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.22078859 |
| 60 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.19767653 |
| 61 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.18522881 |
| 62 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.18402962 |
| 63 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.18303318 |
| 64 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.18016904 |
| 65 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.17005842 |
| 66 | * AR_19668381_ChIP-Seq_PC3_Human | 1.15096565 |
| 67 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.13597860 |
| 68 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.12695696 |
| 69 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.11338021 |
| 70 | AR_25329375_ChIP-Seq_VCAP_Human | 1.10980188 |
| 71 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.10636765 |
| 72 | STAT3_23295773_ChIP-Seq_U87_Human | 1.10227318 |
| 73 | KDM2B_26808549_Chip-Seq_K562_Human | 1.09964416 |
| 74 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.09439970 |
| 75 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.08925477 |
| 76 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.07398849 |
| 77 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.06105087 |
| 78 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.05655075 |
| 79 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.05359888 |
| 80 | FUS_26573619_Chip-Seq_HEK293_Human | 1.04534802 |
| 81 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.03309749 |
| 82 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.02283633 |
| 83 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.00824710 |
| 84 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.00609840 |
| 85 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.99999246 |
| 86 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.99946050 |
| 87 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.98343294 |
| 88 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97581918 |
| 89 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.97091406 |
| 90 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.96840729 |
| 91 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.95324089 |
| 92 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94852387 |
| 93 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94492316 |
| 94 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.92970537 |
| 95 | JUN_21703547_ChIP-Seq_K562_Human | 0.92882240 |
| 96 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.92667949 |
| 97 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.92604489 |
| 98 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92404071 |
| 99 | TCF4_23295773_ChIP-Seq_U87_Human | 0.91773032 |
| 100 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91650831 |
| 101 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.91626277 |
| 102 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.91281648 |
| 103 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.90101266 |
| 104 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.89899674 |
| 105 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.89629613 |
| 106 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.89579251 |
| 107 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.88546177 |
| 108 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.88546177 |
| 109 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.88395835 |
| 110 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.87497411 |
| 111 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.86900690 |
| 112 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.86863512 |
| 113 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.86627192 |
| 114 | * CTCF_27219007_Chip-Seq_Bcells_Human | 0.86142760 |
| 115 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.85425395 |
| 116 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.84970145 |
| 117 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.84655923 |
| 118 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.84647583 |
| 119 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.84598473 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.31751665 |
| 2 | MP0003880_abnormal_central_pattern | 4.42547540 |
| 3 | MP0004270_analgesia | 3.67422395 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.60191317 |
| 5 | MP0005423_abnormal_somatic_nervous | 3.35588865 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.03218299 |
| 7 | MP0001968_abnormal_touch/_nociception | 2.88351236 |
| 8 | MP0002734_abnormal_mechanical_nocicepti | 2.80166548 |
| 9 | MP0006276_abnormal_autonomic_nervous | 2.76597904 |
| 10 | MP0000778_abnormal_nervous_system | 2.72389225 |
| 11 | MP0009745_abnormal_behavioral_response | 2.68245064 |
| 12 | MP0002735_abnormal_chemical_nociception | 2.53415773 |
| 13 | MP0002064_seizures | 2.48730332 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.46179748 |
| 15 | MP0009046_muscle_twitch | 2.36787813 |
| 16 | MP0003123_paternal_imprinting | 2.34686246 |
| 17 | MP0002184_abnormal_innervation | 2.34229337 |
| 18 | MP0001984_abnormal_olfaction | 2.24161713 |
| 19 | MP0002733_abnormal_thermal_nociception | 2.23899280 |
| 20 | MP0001486_abnormal_startle_reflex | 2.22051262 |
| 21 | MP0002736_abnormal_nociception_after | 2.15459374 |
| 22 | MP0002272_abnormal_nervous_system | 2.14773369 |
| 23 | MP0004858_abnormal_nervous_system | 2.13535074 |
| 24 | MP0005645_abnormal_hypothalamus_physiol | 2.04685434 |
| 25 | MP0006292_abnormal_olfactory_placode | 2.04094619 |
| 26 | MP0001440_abnormal_grooming_behavior | 2.03493334 |
| 27 | MP0001970_abnormal_pain_threshold | 1.98781213 |
| 28 | MP0003122_maternal_imprinting | 1.92118429 |
| 29 | MP0004811_abnormal_neuron_physiology | 1.89760856 |
| 30 | MP0003329_amyloid_beta_deposits | 1.87492332 |
| 31 | MP0002067_abnormal_sensory_capabilities | 1.85730992 |
| 32 | MP0000955_abnormal_spinal_cord | 1.83746896 |
| 33 | MP0002557_abnormal_social/conspecific_i | 1.83273934 |
| 34 | MP0000566_synostosis | 1.77377583 |
| 35 | MP0009780_abnormal_chondrocyte_physiolo | 1.74845147 |
| 36 | MP0000569_abnormal_digit_pigmentation | 1.74645359 |
| 37 | MP0004924_abnormal_behavior | 1.64747475 |
| 38 | MP0005386_behavior/neurological_phenoty | 1.64747475 |
| 39 | MP0002882_abnormal_neuron_morphology | 1.62570096 |
| 40 | MP0010386_abnormal_urinary_bladder | 1.61662489 |
| 41 | MP0009379_abnormal_foot_pigmentation | 1.60531267 |
| 42 | MP0001529_abnormal_vocalization | 1.59137497 |
| 43 | MP0004133_heterotaxia | 1.58043370 |
| 44 | MP0001501_abnormal_sleep_pattern | 1.56001372 |
| 45 | MP0002909_abnormal_adrenal_gland | 1.44600255 |
| 46 | MP0008569_lethality_at_weaning | 1.43538486 |
| 47 | MP0001502_abnormal_circadian_rhythm | 1.41067026 |
| 48 | MP0003879_abnormal_hair_cell | 1.39346632 |
| 49 | MP0003890_abnormal_embryonic-extraembry | 1.37695701 |
| 50 | MP0002066_abnormal_motor_capabilities/c | 1.36527356 |
| 51 | MP0004742_abnormal_vestibular_system | 1.33976463 |
| 52 | MP0002152_abnormal_brain_morphology | 1.28470566 |
| 53 | MP0008877_abnormal_DNA_methylation | 1.28168389 |
| 54 | MP0005646_abnormal_pituitary_gland | 1.22261621 |
| 55 | MP0001485_abnormal_pinna_reflex | 1.20442887 |
| 56 | MP0002822_catalepsy | 1.19989980 |
| 57 | MP0003938_abnormal_ear_development | 1.19917161 |
| 58 | MP0001299_abnormal_eye_distance/ | 1.19792256 |
| 59 | MP0004885_abnormal_endolymph | 1.17484238 |
| 60 | MP0001905_abnormal_dopamine_level | 1.15044270 |
| 61 | MP0004142_abnormal_muscle_tone | 1.13891638 |
| 62 | MP0000751_myopathy | 1.11030170 |
| 63 | MP0005551_abnormal_eye_electrophysiolog | 1.10956019 |
| 64 | MP0002638_abnormal_pupillary_reflex | 1.10601897 |
| 65 | MP0005499_abnormal_olfactory_system | 1.09606430 |
| 66 | MP0005394_taste/olfaction_phenotype | 1.09606430 |
| 67 | MP0003136_yellow_coat_color | 1.08890735 |
| 68 | MP0002752_abnormal_somatic_nervous | 1.07971378 |
| 69 | MP0002102_abnormal_ear_morphology | 1.07306869 |
| 70 | MP0001348_abnormal_lacrimal_gland | 1.07221683 |
| 71 | MP0003942_abnormal_urinary_system | 1.05509608 |
| 72 | MP0000049_abnormal_middle_ear | 1.04469214 |
| 73 | MP0000631_abnormal_neuroendocrine_gland | 1.03506439 |
| 74 | MP0003634_abnormal_glial_cell | 1.03087746 |
| 75 | MP0001188_hyperpigmentation | 1.02833978 |
| 76 | MP0003283_abnormal_digestive_organ | 1.00502007 |
| 77 | MP0000013_abnormal_adipose_tissue | 1.00185401 |
| 78 | MP0005623_abnormal_meninges_morphology | 0.99758228 |
| 79 | MP0002751_abnormal_autonomic_nervous | 0.99722847 |
| 80 | MP0003011_delayed_dark_adaptation | 0.99142473 |
| 81 | MP0003861_abnormal_nervous_system | 0.95428875 |
| 82 | MP0003787_abnormal_imprinting | 0.94389503 |
| 83 | MP0002163_abnormal_gland_morphology | 0.94015957 |
| 84 | MP0002229_neurodegeneration | 0.93785328 |
| 85 | MP0005195_abnormal_posterior_eye | 0.92601665 |
| 86 | MP0003119_abnormal_digestive_system | 0.92286187 |
| 87 | MP0003633_abnormal_nervous_system | 0.90735620 |
| 88 | MP0002069_abnormal_eating/drinking_beha | 0.88351956 |
| 89 | MP0002160_abnormal_reproductive_system | 0.87064933 |
| 90 | MP0003631_nervous_system_phenotype | 0.85198730 |
| 91 | MP0002938_white_spotting | 0.84301985 |
| 92 | MP0001293_anophthalmia | 0.83522810 |
| 93 | MP0002928_abnormal_bile_duct | 0.81845309 |
| 94 | MP0008961_abnormal_basal_metabolism | 0.79827926 |
| 95 | MP0006072_abnormal_retinal_apoptosis | 0.79706215 |
| 96 | MP0001177_atelectasis | 0.79428924 |
| 97 | MP0002234_abnormal_pharynx_morphology | 0.78760716 |
| 98 | MP0004145_abnormal_muscle_electrophysio | 0.77996143 |
| 99 | MP0003137_abnormal_impulse_conducting | 0.77313375 |
| 100 | MP0004233_abnormal_muscle_weight | 0.75845057 |
| 101 | MP0003315_abnormal_perineum_morphology | 0.75443932 |
| 102 | MP0001963_abnormal_hearing_physiology | 0.75014082 |
| 103 | MP0003937_abnormal_limbs/digits/tail_de | 0.72620225 |
| 104 | MP0000534_abnormal_ureter_morphology | 0.72226209 |
| 105 | MP0001286_abnormal_eye_development | 0.70364856 |
| 106 | MP0003121_genomic_imprinting | 0.70178978 |
| 107 | MP0008789_abnormal_olfactory_epithelium | 0.69678627 |
| 108 | MP0004085_abnormal_heartbeat | 0.69665246 |
| 109 | MP0002090_abnormal_vision | 0.68986926 |
| 110 | MP0003632_abnormal_nervous_system | 0.68868055 |
| 111 | MP0002653_abnormal_ependyma_morphology | 0.68723076 |
| 112 | MP0004130_abnormal_muscle_cell | 0.68579254 |
| 113 | MP0000604_amyloidosis | 0.68504759 |
| 114 | MP0000026_abnormal_inner_ear | 0.62633537 |
| 115 | MP0001943_abnormal_respiration | 0.62179987 |
| 116 | MP0005187_abnormal_penis_morphology | 0.61471155 |
| 117 | MP0000920_abnormal_myelination | 0.60718561 |
| 118 | MP0002081_perinatal_lethality | 0.60245646 |
| 119 | MP0005253_abnormal_eye_physiology | 0.60052205 |
| 120 | MP0000538_abnormal_urinary_bladder | 0.59346326 |
| 121 | MP0002082_postnatal_lethality | 0.57919384 |
| 122 | MP0010770_preweaning_lethality | 0.57919384 |
| 123 | MP0010769_abnormal_survival | 0.57355688 |
| 124 | MP0002089_abnormal_postnatal_growth/wei | 0.53978139 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 5.63822562 |
| 2 | Focal motor seizures (HP:0011153) | 5.12145960 |
| 3 | Focal seizures (HP:0007359) | 4.57922289 |
| 4 | Supranuclear gaze palsy (HP:0000605) | 4.10631382 |
| 5 | Visual hallucinations (HP:0002367) | 4.05999835 |
| 6 | Epileptic encephalopathy (HP:0200134) | 3.89602410 |
| 7 | Mutism (HP:0002300) | 3.78392996 |
| 8 | Ankle clonus (HP:0011448) | 3.73252487 |
| 9 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.70729168 |
| 10 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.70729168 |
| 11 | Progressive cerebellar ataxia (HP:0002073) | 3.69227465 |
| 12 | Polyphagia (HP:0002591) | 3.67923946 |
| 13 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.66392601 |
| 14 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.51609390 |
| 15 | Absent/shortened dynein arms (HP:0200106) | 3.51609390 |
| 16 | Limb dystonia (HP:0002451) | 3.50980989 |
| 17 | Atonic seizures (HP:0010819) | 3.43795450 |
| 18 | Abnormal ciliary motility (HP:0012262) | 3.38621163 |
| 19 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.37131897 |
| 20 | Febrile seizures (HP:0002373) | 3.35772343 |
| 21 | Action tremor (HP:0002345) | 3.35150973 |
| 22 | Failure to thrive in infancy (HP:0001531) | 3.28504847 |
| 23 | Absence seizures (HP:0002121) | 3.27564073 |
| 24 | Insidious onset (HP:0003587) | 3.24656863 |
| 25 | Termporal pattern (HP:0011008) | 3.24656863 |
| 26 | Abnormal eating behavior (HP:0100738) | 3.17720526 |
| 27 | Abnormality of midbrain morphology (HP:0002418) | 3.09512948 |
| 28 | Molar tooth sign on MRI (HP:0002419) | 3.09512948 |
| 29 | Nephronophthisis (HP:0000090) | 3.09326238 |
| 30 | Abnormality of the corticospinal tract (HP:0002492) | 3.07565790 |
| 31 | Generalized tonic-clonic seizures (HP:0002069) | 2.98742336 |
| 32 | Pancreatic fibrosis (HP:0100732) | 2.96781847 |
| 33 | Broad-based gait (HP:0002136) | 2.88353558 |
| 34 | Drooling (HP:0002307) | 2.88205683 |
| 35 | Excessive salivation (HP:0003781) | 2.88205683 |
| 36 | Dialeptic seizures (HP:0011146) | 2.87602278 |
| 37 | Amblyopia (HP:0000646) | 2.85108209 |
| 38 | True hermaphroditism (HP:0010459) | 2.81926332 |
| 39 | Amyotrophic lateral sclerosis (HP:0007354) | 2.81120900 |
| 40 | Neurofibrillary tangles (HP:0002185) | 2.79697929 |
| 41 | Hepatoblastoma (HP:0002884) | 2.77752689 |
| 42 | Rhinitis (HP:0012384) | 2.73704737 |
| 43 | Medial flaring of the eyebrow (HP:0010747) | 2.73575220 |
| 44 | Urinary urgency (HP:0000012) | 2.70309454 |
| 45 | Poor eye contact (HP:0000817) | 2.65329023 |
| 46 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.63848923 |
| 47 | Cerebral inclusion bodies (HP:0100314) | 2.63746792 |
| 48 | Depression (HP:0000716) | 2.58881837 |
| 49 | Spastic gait (HP:0002064) | 2.58125579 |
| 50 | Truncal ataxia (HP:0002078) | 2.56121941 |
| 51 | Papilledema (HP:0001085) | 2.55873001 |
| 52 | Torticollis (HP:0000473) | 2.54336109 |
| 53 | Pheochromocytoma (HP:0002666) | 2.52611826 |
| 54 | Hypoplasia of the brainstem (HP:0002365) | 2.51872943 |
| 55 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.51872943 |
| 56 | Pancreatic cysts (HP:0001737) | 2.51036078 |
| 57 | Genetic anticipation (HP:0003743) | 2.49611570 |
| 58 | Congenital primary aphakia (HP:0007707) | 2.49588462 |
| 59 | Megalencephaly (HP:0001355) | 2.49118792 |
| 60 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.49030247 |
| 61 | Abnormality of the renal medulla (HP:0100957) | 2.46695582 |
| 62 | Agitation (HP:0000713) | 2.45551553 |
| 63 | Akinesia (HP:0002304) | 2.45007334 |
| 64 | Lissencephaly (HP:0001339) | 2.42175528 |
| 65 | EEG with generalized epileptiform discharges (HP:0011198) | 2.41746955 |
| 66 | Impaired social interactions (HP:0000735) | 2.41163228 |
| 67 | Abnormal social behavior (HP:0012433) | 2.41163228 |
| 68 | Lower limb muscle weakness (HP:0007340) | 2.40812826 |
| 69 | Vaginal atresia (HP:0000148) | 2.40695018 |
| 70 | Epileptiform EEG discharges (HP:0011182) | 2.39363152 |
| 71 | Hypoventilation (HP:0002791) | 2.37129560 |
| 72 | Genital tract atresia (HP:0001827) | 2.35668003 |
| 73 | Rib fusion (HP:0000902) | 2.34490929 |
| 74 | Nephrogenic diabetes insipidus (HP:0009806) | 2.34235121 |
| 75 | Abnormality of the lower motor neuron (HP:0002366) | 2.32641605 |
| 76 | Chronic hepatic failure (HP:0100626) | 2.31357001 |
| 77 | Hemiparesis (HP:0001269) | 2.31207990 |
| 78 | Abnormal pancreas size (HP:0012094) | 2.30771870 |
| 79 | Anencephaly (HP:0002323) | 2.29622584 |
| 80 | Fetal akinesia sequence (HP:0001989) | 2.26393107 |
| 81 | Cystic liver disease (HP:0006706) | 2.20760104 |
| 82 | Hypsarrhythmia (HP:0002521) | 2.20439290 |
| 83 | Anxiety (HP:0000739) | 2.20244588 |
| 84 | Insomnia (HP:0100785) | 2.17930372 |
| 85 | Sleep apnea (HP:0010535) | 2.17442923 |
| 86 | Progressive inability to walk (HP:0002505) | 2.17132095 |
| 87 | Neuroendocrine neoplasm (HP:0100634) | 2.13754931 |
| 88 | Oligodactyly (hands) (HP:0001180) | 2.13748090 |
| 89 | Focal dystonia (HP:0004373) | 2.12457821 |
| 90 | Dysdiadochokinesis (HP:0002075) | 2.11173474 |
| 91 | Ulnar claw (HP:0001178) | 2.10056189 |
| 92 | Occipital encephalocele (HP:0002085) | 2.08965906 |
| 93 | Spastic tetraplegia (HP:0002510) | 2.08901677 |
| 94 | Gait imbalance (HP:0002141) | 2.08154329 |
| 95 | Dysmetria (HP:0001310) | 2.05974620 |
| 96 | Stereotypic behavior (HP:0000733) | 2.04356303 |
| 97 | Craniofacial dystonia (HP:0012179) | 2.03770836 |
| 98 | Hyperventilation (HP:0002883) | 2.03140298 |
| 99 | Specific learning disability (HP:0001328) | 2.02519983 |
| 100 | Cortical dysplasia (HP:0002539) | 2.02397751 |
| 101 | Apathy (HP:0000741) | 2.02304947 |
| 102 | Aqueductal stenosis (HP:0002410) | 2.02148386 |
| 103 | Abnormality of salivation (HP:0100755) | 2.01980892 |
| 104 | Abnormality of the labia minora (HP:0012880) | 2.01969361 |
| 105 | Septo-optic dysplasia (HP:0100842) | 2.01206958 |
| 106 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.00852415 |
| 107 | Anosmia (HP:0000458) | 2.00422889 |
| 108 | Sclerocornea (HP:0000647) | 1.99111605 |
| 109 | Exotropia (HP:0000577) | 1.99064001 |
| 110 | Absent speech (HP:0001344) | 1.96767958 |
| 111 | Growth hormone deficiency (HP:0000824) | 1.96767906 |
| 112 | Inappropriate behavior (HP:0000719) | 1.96284344 |
| 113 | Short 4th metacarpal (HP:0010044) | 1.96119428 |
| 114 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.96119428 |
| 115 | Abnormality of binocular vision (HP:0011514) | 1.93644472 |
| 116 | Diplopia (HP:0000651) | 1.93644472 |
| 117 | Gaze-evoked nystagmus (HP:0000640) | 1.93540982 |
| 118 | Poor coordination (HP:0002370) | 1.93246358 |
| 119 | Osteomalacia (HP:0002749) | 1.93049414 |
| 120 | Pachygyria (HP:0001302) | 1.91872610 |
| 121 | Narrow forehead (HP:0000341) | 1.91308070 |
| 122 | Optic nerve hypoplasia (HP:0000609) | 1.90898749 |
| 123 | Open mouth (HP:0000194) | 1.90617654 |
| 124 | Clonus (HP:0002169) | 1.90148384 |
| 125 | Esotropia (HP:0000565) | 1.90057955 |
| 126 | Postural instability (HP:0002172) | 1.86546649 |
| 127 | Diastasis recti (HP:0001540) | 1.86388479 |
| 128 | Shawl scrotum (HP:0000049) | 1.85791351 |
| 129 | Postaxial hand polydactyly (HP:0001162) | 1.84756688 |
| 130 | Lower limb amyotrophy (HP:0007210) | 1.84603542 |
| 131 | Anophthalmia (HP:0000528) | 1.84548463 |
| 132 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.83617245 |
| 133 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.83617245 |
| 134 | Poor suck (HP:0002033) | 1.83443595 |
| 135 | Inability to walk (HP:0002540) | 1.82572634 |
| 136 | Shoulder girdle muscle weakness (HP:0003547) | 1.81994890 |
| 137 | Hammertoe (HP:0001765) | 1.80777097 |
| 138 | Bradykinesia (HP:0002067) | 1.79479501 |
| 139 | Pointed chin (HP:0000307) | 1.79383827 |
| 140 | Diminished motivation (HP:0000745) | 1.77392564 |
| 141 | Central scotoma (HP:0000603) | 1.75337164 |
| 142 | Cutaneous finger syndactyly (HP:0010554) | 1.74826896 |
| 143 | Chronic bronchitis (HP:0004469) | 1.73586717 |
| 144 | Narrow nasal bridge (HP:0000446) | 1.73420846 |
| 145 | Hypogonadotrophic hypogonadism (HP:0000044) | 1.73238936 |
| 146 | Postaxial foot polydactyly (HP:0001830) | 1.71036128 |
| 147 | Retinal dysplasia (HP:0007973) | 1.70994248 |
| 148 | Type II lissencephaly (HP:0007260) | 1.68887982 |
| 149 | Scanning speech (HP:0002168) | 1.68551543 |
| 150 | Neuronal loss in central nervous system (HP:0002529) | 1.67963430 |
| 151 | Abnormality of the aortic arch (HP:0012303) | 1.66719883 |
| 152 | Hip dysplasia (HP:0001385) | 1.65838606 |
| 153 | Aplasia of the phalanges of the hand (HP:0009802) | 1.64934714 |
| 154 | Aplasia involving bones of the extremities (HP:0009825) | 1.64934714 |
| 155 | Neoplasm of the adrenal cortex (HP:0100641) | 1.64617686 |
| 156 | Labial hypoplasia (HP:0000066) | 1.63631669 |
| 157 | Renal hypoplasia (HP:0000089) | 1.62984898 |
| 158 | Hypoplasia of the corpus callosum (HP:0002079) | 1.62618535 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 5.97361631 |
| 2 | MAP3K9 | 3.82493407 |
| 3 | NTRK3 | 3.41608949 |
| 4 | MINK1 | 3.15694130 |
| 5 | MAP3K4 | 2.59296882 |
| 6 | EPHA4 | 2.42629216 |
| 7 | NTRK2 | 2.38996582 |
| 8 | PAK6 | 2.38609274 |
| 9 | KSR1 | 2.18789095 |
| 10 | MAP2K7 | 2.11800106 |
| 11 | MAPK13 | 2.09340046 |
| 12 | LATS2 | 1.97036426 |
| 13 | PHKG2 | 1.92986694 |
| 14 | PHKG1 | 1.92986694 |
| 15 | CASK | 1.91139543 |
| 16 | NTRK1 | 1.84686914 |
| 17 | DAPK2 | 1.72785053 |
| 18 | DYRK2 | 1.72191970 |
| 19 | WNK4 | 1.71123030 |
| 20 | KSR2 | 1.70792196 |
| 21 | MAPK15 | 1.66224787 |
| 22 | MAP2K4 | 1.57849189 |
| 23 | CAMKK1 | 1.52590266 |
| 24 | MAP3K12 | 1.50304313 |
| 25 | LIMK1 | 1.48982289 |
| 26 | CDK5 | 1.48040339 |
| 27 | SIK2 | 1.42941663 |
| 28 | PINK1 | 1.42821409 |
| 29 | UHMK1 | 1.39722324 |
| 30 | ERBB3 | 1.33657366 |
| 31 | PAK3 | 1.32414009 |
| 32 | PNCK | 1.26455622 |
| 33 | CAMKK2 | 1.17705914 |
| 34 | PRPF4B | 1.17529815 |
| 35 | DYRK3 | 1.16262590 |
| 36 | BCR | 1.15608005 |
| 37 | STK16 | 1.14844505 |
| 38 | SIK3 | 1.12632178 |
| 39 | MARK2 | 1.11785756 |
| 40 | CDK18 | 1.11082914 |
| 41 | PRKD3 | 1.09775334 |
| 42 | CDK14 | 1.08783973 |
| 43 | GRK5 | 1.07821471 |
| 44 | TYRO3 | 1.07590439 |
| 45 | PLK2 | 1.07535981 |
| 46 | CDK15 | 1.04414510 |
| 47 | PRKCG | 1.03598597 |
| 48 | DYRK1B | 1.02857457 |
| 49 | CSNK1G2 | 1.02036975 |
| 50 | CAMK1G | 1.00937181 |
| 51 | EPHB2 | 0.95309346 |
| 52 | TNIK | 0.91661031 |
| 53 | CDK11A | 0.90904768 |
| 54 | TAOK1 | 0.87885611 |
| 55 | ADRBK2 | 0.87580107 |
| 56 | RET | 0.86630348 |
| 57 | DYRK1A | 0.82194132 |
| 58 | MAP3K2 | 0.80215904 |
| 59 | SGK494 | 0.78949835 |
| 60 | SGK223 | 0.78949835 |
| 61 | CAMK2A | 0.78909025 |
| 62 | DAPK1 | 0.77517550 |
| 63 | STK39 | 0.77431926 |
| 64 | BMPR1B | 0.76158586 |
| 65 | WNK3 | 0.74813458 |
| 66 | FRK | 0.74368601 |
| 67 | CDK19 | 0.74162713 |
| 68 | RPS6KA2 | 0.69517581 |
| 69 | PRKCZ | 0.68087220 |
| 70 | STK11 | 0.67881146 |
| 71 | LMTK2 | 0.66349721 |
| 72 | ARAF | 0.65716292 |
| 73 | STK38 | 0.65247520 |
| 74 | DDR2 | 0.64869992 |
| 75 | CSNK1G3 | 0.64613945 |
| 76 | PKN1 | 0.63944651 |
| 77 | FER | 0.61486374 |
| 78 | IRAK2 | 0.60707065 |
| 79 | SGK3 | 0.60007329 |
| 80 | CSNK1E | 0.57993210 |
| 81 | CAMK2B | 0.57130251 |
| 82 | PRKCE | 0.56417244 |
| 83 | CAMK1 | 0.54325279 |
| 84 | PRKCH | 0.54262632 |
| 85 | MAP2K1 | 0.53671638 |
| 86 | ICK | 0.53519881 |
| 87 | GRK1 | 0.52394442 |
| 88 | CDC42BPA | 0.52126164 |
| 89 | PRKACA | 0.51983058 |
| 90 | CSNK1A1L | 0.50698732 |
| 91 | FES | 0.50010702 |
| 92 | EPHA3 | 0.49973636 |
| 93 | FGFR2 | 0.49925846 |
| 94 | MKNK2 | 0.48835724 |
| 95 | WNK1 | 0.48551828 |
| 96 | MAP3K11 | 0.47300887 |
| 97 | FYN | 0.45996837 |
| 98 | ROCK2 | 0.44461004 |
| 99 | PRKG1 | 0.44052142 |
| 100 | CAMK1D | 0.43819182 |
| 101 | SGK1 | 0.42809098 |
| 102 | ROCK1 | 0.42632251 |
| 103 | CAMK4 | 0.41293316 |
| 104 | CSNK1G1 | 0.40253066 |
| 105 | TLK1 | 0.40193370 |
| 106 | ADRBK1 | 0.39150777 |
| 107 | RIPK4 | 0.38513757 |
| 108 | MAPK9 | 0.38350673 |
| 109 | RAF1 | 0.37548059 |
| 110 | PDGFRA | 0.37263420 |
| 111 | OXSR1 | 0.36974319 |
| 112 | MAPK12 | 0.36738106 |
| 113 | PRKAA1 | 0.36711848 |
| 114 | CSNK1A1 | 0.36610040 |
| 115 | ALK | 0.36601830 |
| 116 | CAMK2D | 0.35248510 |
| 117 | SGK2 | 0.35194696 |
| 118 | SCYL2 | 0.35041115 |
| 119 | RPS6KA3 | 0.34731145 |
| 120 | NEK1 | 0.34333829 |
| 121 | MAP4K2 | 0.34120996 |
| 122 | INSRR | 0.34113800 |
| 123 | DMPK | 0.33827968 |
| 124 | ERBB2 | 0.33770051 |
| 125 | TESK1 | 0.33314321 |
| 126 | MAPK10 | 0.32467339 |
| 127 | CSNK1D | 0.31897186 |
| 128 | MAPK8 | 0.31203103 |
| 129 | PRKCB | 0.30667602 |
| 130 | GSK3B | 0.29471035 |
| 131 | TRIM28 | 0.28258825 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.30779136 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.27695705 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.53169105 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.46314882 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.37759752 |
| 6 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.36890715 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.24287757 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.20317146 |
| 9 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.20068810 |
| 10 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.14658728 |
| 11 | Long-term potentiation_Homo sapiens_hsa04720 | 2.03950121 |
| 12 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.03014299 |
| 13 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.02406003 |
| 14 | Axon guidance_Homo sapiens_hsa04360 | 2.01674323 |
| 15 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.93481799 |
| 16 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.91922238 |
| 17 | Parkinsons disease_Homo sapiens_hsa05012 | 1.82928829 |
| 18 | Insulin secretion_Homo sapiens_hsa04911 | 1.81443291 |
| 19 | Salivary secretion_Homo sapiens_hsa04970 | 1.75715620 |
| 20 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.71915428 |
| 21 | Taste transduction_Homo sapiens_hsa04742 | 1.68644866 |
| 22 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.67270099 |
| 23 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.66446286 |
| 24 | Cocaine addiction_Homo sapiens_hsa05030 | 1.62137498 |
| 25 | Gap junction_Homo sapiens_hsa04540 | 1.60736984 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.55143548 |
| 27 | Renin secretion_Homo sapiens_hsa04924 | 1.54356493 |
| 28 | Long-term depression_Homo sapiens_hsa04730 | 1.54224175 |
| 29 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.53896189 |
| 30 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.49065551 |
| 31 | Huntingtons disease_Homo sapiens_hsa05016 | 1.47622345 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.46625128 |
| 33 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.41199576 |
| 34 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.40255370 |
| 35 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.30232962 |
| 36 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.26172490 |
| 37 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.25818353 |
| 38 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.25216951 |
| 39 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.19672886 |
| 40 | Glioma_Homo sapiens_hsa05214 | 1.19648592 |
| 41 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.19027124 |
| 42 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.16601171 |
| 43 | Phototransduction_Homo sapiens_hsa04744 | 1.07189621 |
| 44 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.07153735 |
| 45 | Melanogenesis_Homo sapiens_hsa04916 | 1.06317723 |
| 46 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.05392892 |
| 47 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.03516435 |
| 48 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.01896763 |
| 49 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.99367663 |
| 50 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.97436549 |
| 51 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.97372308 |
| 52 | Endometrial cancer_Homo sapiens_hsa05213 | 0.91982317 |
| 53 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.91316419 |
| 54 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.90166608 |
| 55 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.90123095 |
| 56 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.89536038 |
| 57 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.89037974 |
| 58 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.87261095 |
| 59 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.87218527 |
| 60 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.86780159 |
| 61 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.85718900 |
| 62 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.85519300 |
| 63 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.85101860 |
| 64 | Colorectal cancer_Homo sapiens_hsa05210 | 0.84291385 |
| 65 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.83347217 |
| 66 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.81512616 |
| 67 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.80618747 |
| 68 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.80097920 |
| 69 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.79478996 |
| 70 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.77984689 |
| 71 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.77570595 |
| 72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.77274811 |
| 73 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.77260562 |
| 74 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.77024536 |
| 75 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.75109827 |
| 76 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.74959914 |
| 77 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.74712849 |
| 78 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.74646384 |
| 79 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.74232133 |
| 80 | Ribosome_Homo sapiens_hsa03010 | 0.72667844 |
| 81 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.71858879 |
| 82 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.68794326 |
| 83 | Alcoholism_Homo sapiens_hsa05034 | 0.66846324 |
| 84 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.65121834 |
| 85 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.64048934 |
| 86 | Endocytosis_Homo sapiens_hsa04144 | 0.63288951 |
| 87 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.63286688 |
| 88 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.62484082 |
| 89 | Prion diseases_Homo sapiens_hsa05020 | 0.62000567 |
| 90 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.60632860 |
| 91 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.57565187 |
| 92 | Protein export_Homo sapiens_hsa03060 | 0.56746336 |
| 93 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.56682757 |
| 94 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.55874441 |
| 95 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.54622977 |
| 96 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.54609640 |
| 97 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.54607677 |
| 98 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.52666107 |
| 99 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.52440088 |
| 100 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.52301518 |
| 101 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.52234806 |
| 102 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.52206445 |
| 103 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.51384129 |
| 104 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.51156828 |
| 105 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.50711831 |
| 106 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.49470665 |
| 107 | Phagosome_Homo sapiens_hsa04145 | 0.48124788 |
| 108 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.46405278 |
| 109 | Bile secretion_Homo sapiens_hsa04976 | 0.45740997 |
| 110 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.44094267 |
| 111 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.43222690 |
| 112 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.41983260 |
| 113 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.41939468 |
| 114 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.41894776 |
| 115 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.41414962 |
| 116 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.40794565 |
| 117 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.40782817 |
| 118 | Tight junction_Homo sapiens_hsa04530 | 0.40479000 |
| 119 | Melanoma_Homo sapiens_hsa05218 | 0.39981713 |
| 120 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.39889654 |
| 121 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.39649352 |
| 122 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.38874008 |
| 123 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.38776813 |
| 124 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.37577043 |
| 125 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37181171 |
| 126 | Circadian rhythm_Homo sapiens_hsa04710 | 0.31296068 |
| 127 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.30340912 |
| 128 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.27168260 |

