MAP6D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.79615441
2axon ensheathment in central nervous system (GO:0032291)9.79615441
3synaptic vesicle docking involved in exocytosis (GO:0016081)7.57585332
4cellular potassium ion homeostasis (GO:0030007)6.18393790
5fatty acid elongation (GO:0030497)5.91430372
6myelination (GO:0042552)5.86616009
7axon ensheathment (GO:0008366)5.86349434
8ensheathment of neurons (GO:0007272)5.86349434
9sodium ion export (GO:0071436)5.71254267
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.48723076
11long-chain fatty acid biosynthetic process (GO:0042759)5.24837410
12neurotransmitter secretion (GO:0007269)5.11040320
13regulation of synaptic vesicle transport (GO:1902803)5.01938931
14positive regulation of synapse maturation (GO:0090129)4.95713226
15L-amino acid import (GO:0043092)4.66600982
16potassium ion homeostasis (GO:0055075)4.44194688
17negative regulation of neurotransmitter secretion (GO:0046929)4.39127492
18negative regulation of neurotransmitter transport (GO:0051589)4.37428009
19presynaptic membrane organization (GO:0097090)4.28563467
20potassium ion import (GO:0010107)4.17192190
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.15368043
22neurotransmitter transport (GO:0006836)4.12423558
23presynaptic membrane assembly (GO:0097105)4.07577832
24neuronal action potential propagation (GO:0019227)4.02454786
25neuron cell-cell adhesion (GO:0007158)4.01129858
26myelin maintenance (GO:0043217)3.99255391
27transmission of nerve impulse (GO:0019226)3.97629572
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.94749247
29glycerophospholipid catabolic process (GO:0046475)3.91740507
30exploration behavior (GO:0035640)3.91401500
31establishment of mitochondrion localization (GO:0051654)3.90575527
32postsynaptic membrane organization (GO:0001941)3.88594308
33oligodendrocyte differentiation (GO:0048709)3.84714104
34neuromuscular process controlling balance (GO:0050885)3.84335247
35regulation of synaptic plasticity (GO:0048167)3.83343305
36negative regulation of protein localization to cell surface (GO:2000009)3.79932896
37apical protein localization (GO:0045176)3.79503825
38regulation of synapse maturation (GO:0090128)3.72979227
39adult walking behavior (GO:0007628)3.72671887
40regulation of collateral sprouting (GO:0048670)3.71578610
41regulation of neurotransmitter levels (GO:0001505)3.70544292
42synaptic vesicle maturation (GO:0016188)3.60907636
43regulation of glutamate receptor signaling pathway (GO:1900449)3.58983205
44cell communication by electrical coupling (GO:0010644)3.58613107
45negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.57830638
46synaptic vesicle endocytosis (GO:0048488)3.57468157
47regulation of ARF protein signal transduction (GO:0032012)3.56958506
48regulation of neurotransmitter secretion (GO:0046928)3.56245180
49response to methylmercury (GO:0051597)3.55908386
50regulation of synapse structural plasticity (GO:0051823)3.54699078
51positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.53832091
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51829865
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.50957493
54positive regulation of dendritic spine development (GO:0060999)3.49288758
55amino acid import (GO:0043090)3.48574347
56astrocyte development (GO:0014002)3.45270655
57asymmetric protein localization (GO:0008105)3.44364405
58negative regulation of dendrite morphogenesis (GO:0050774)3.43528876
59acidic amino acid transport (GO:0015800)3.43450480
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41898293
61peptidyl-tyrosine autophosphorylation (GO:0038083)3.41350473
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.40664354
63substantia nigra development (GO:0021762)3.39578840
64cellular sodium ion homeostasis (GO:0006883)3.37838931
65layer formation in cerebral cortex (GO:0021819)3.37638398
66cholesterol biosynthetic process (GO:0006695)3.36991038
67photoreceptor cell differentiation (GO:0046530)3.36712058
68eye photoreceptor cell differentiation (GO:0001754)3.36712058
69long-term memory (GO:0007616)3.34632609
70neuronal ion channel clustering (GO:0045161)3.33537990
71regulation of neurotransmitter transport (GO:0051588)3.30035375
72creatine metabolic process (GO:0006600)3.27285132
73dendritic spine morphogenesis (GO:0060997)3.26093412
74ionotropic glutamate receptor signaling pathway (GO:0035235)3.25468448
75cerebellar Purkinje cell differentiation (GO:0021702)3.23060405
76locomotory exploration behavior (GO:0035641)3.21376282
77regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.20384958
78cerebellar granule cell differentiation (GO:0021707)3.19214550
79synaptic vesicle exocytosis (GO:0016079)3.18509785
80neuromuscular synaptic transmission (GO:0007274)3.16477927
81regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13230798
82regulation of vesicle fusion (GO:0031338)3.11451638
83long-term synaptic potentiation (GO:0060291)3.10180906
84negative regulation of axonogenesis (GO:0050771)3.09879639
85cerebellar Purkinje cell layer development (GO:0021680)3.07932385
86positive regulation of oligodendrocyte differentiation (GO:0048714)3.07773191
87import into cell (GO:0098657)3.04957039
88neurotransmitter-gated ion channel clustering (GO:0072578)3.04667225
89L-glutamate transport (GO:0015813)3.04023471
90positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04011711
91positive regulation of neurotransmitter transport (GO:0051590)3.03846431
92regulation of postsynaptic membrane potential (GO:0060078)3.03750850
93gamma-aminobutyric acid signaling pathway (GO:0007214)3.03096787
94response to redox state (GO:0051775)3.02191243
95regulation of synaptic transmission (GO:0050804)3.01465157
96regulation of synaptic vesicle exocytosis (GO:2000300)3.00108640
97neuron recognition (GO:0008038)2.99691341
98peripheral nervous system axon ensheathment (GO:0032292)2.98925867
99myelination in peripheral nervous system (GO:0022011)2.98925867
100activation of protein kinase A activity (GO:0034199)2.98078274
101positive regulation of neurotransmitter secretion (GO:0001956)2.97951214
102regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.97362020
103long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.96053363
104sterol biosynthetic process (GO:0016126)2.95592852
105cerebral cortex radially oriented cell migration (GO:0021799)2.94760557
106glutamate receptor signaling pathway (GO:0007215)2.93695564
107glutamate secretion (GO:0014047)2.93086947
108membrane tubulation (GO:0097320)2.92908361
109nerve growth factor signaling pathway (GO:0038180)2.91521061
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89621529
111neuron-neuron synaptic transmission (GO:0007270)2.88878931
112dicarboxylic acid transport (GO:0006835)2.88857293
113cell communication involved in cardiac conduction (GO:0086065)2.87772116
114synaptic transmission, glutamatergic (GO:0035249)2.87568450
115neuromuscular process (GO:0050905)2.86959376
116protein localization to synapse (GO:0035418)2.84446398
117isoprenoid biosynthetic process (GO:0008299)2.84215208
118regulation of neuronal synaptic plasticity (GO:0048168)2.83754770
119membrane depolarization during action potential (GO:0086010)2.83554927
120glycine transport (GO:0015816)2.82691417
121vesicle docking involved in exocytosis (GO:0006904)2.82221049
122neurotransmitter uptake (GO:0001504)2.81852180
123negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81121412
124vocalization behavior (GO:0071625)2.81079150
125neuron remodeling (GO:0016322)2.80981790
126synaptic transmission (GO:0007268)2.80962165
127gamma-aminobutyric acid transport (GO:0015812)2.79694579
128long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.79176693
129regulation of dendritic spine morphogenesis (GO:0061001)2.77435742
130regulation of voltage-gated calcium channel activity (GO:1901385)2.75124780
131amyloid precursor protein metabolic process (GO:0042982)2.70739733
132positive regulation of membrane potential (GO:0045838)2.70305522
133substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65666671
134substrate-independent telencephalic tangential migration (GO:0021826)2.65666671
135negative regulation of axon extension (GO:0030517)2.65054653
136axonal fasciculation (GO:0007413)2.64753192
137cellular response to epinephrine stimulus (GO:0071872)2.60214412
138regulation of long-term neuronal synaptic plasticity (GO:0048169)2.60115856
139negative regulation of synaptic transmission (GO:0050805)2.59864947
140regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59502993
141magnesium ion transport (GO:0015693)2.57307819
142regulation of catecholamine metabolic process (GO:0042069)2.57280428
143regulation of dopamine metabolic process (GO:0042053)2.57280428
144axon development (GO:0061564)2.57245144
145peripheral nervous system development (GO:0007422)2.55088205
146adult locomotory behavior (GO:0008344)2.53857244
147positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.53323031
148mating behavior (GO:0007617)2.53244411
149neuromuscular process controlling posture (GO:0050884)2.53155522
150regulation of dendritic spine development (GO:0060998)2.52846982
151Golgi to endosome transport (GO:0006895)2.51973801
152mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.51825160
153fatty-acyl-CoA biosynthetic process (GO:0046949)2.51342206
154membrane hyperpolarization (GO:0060081)2.50513704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.71060444
2GBX2_23144817_ChIP-Seq_PC3_Human3.57172326
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.46263718
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.92685765
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86301513
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81989986
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73867601
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44570887
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44570887
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.36659014
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35880464
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.32323966
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31140648
14SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.30994261
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28634241
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.27710486
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26101355
18TAF15_26573619_Chip-Seq_HEK293_Human2.25997032
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24929883
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20677335
21KDM2B_26808549_Chip-Seq_K562_Human2.16511904
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.14988061
23DROSHA_22980978_ChIP-Seq_HELA_Human2.14001167
24AR_21572438_ChIP-Seq_LNCaP_Human2.10126578
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10085977
26DNAJC2_21179169_ChIP-ChIP_NT2_Human2.09088074
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.07063290
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.04005036
29* RARB_27405468_Chip-Seq_BRAIN_Mouse2.02061768
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.00504810
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.96235007
32LXR_22292898_ChIP-Seq_THP-1_Human1.96073350
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.92681453
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88323227
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.88282141
36REST_21632747_ChIP-Seq_MESCs_Mouse1.86198678
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82393051
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.82029703
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72672249
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70555128
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69168603
42TET1_21490601_ChIP-Seq_MESCs_Mouse1.67645528
43* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64469589
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64439652
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64296428
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62816345
47CTCF_27219007_Chip-Seq_Bcells_Human1.62564671
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56085749
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55610778
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.55607233
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.53609330
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51928066
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51447326
54* ESR1_20079471_ChIP-ChIP_T-47D_Human1.50514778
55ER_23166858_ChIP-Seq_MCF-7_Human1.48717663
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48617333
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46478531
58VDR_22108803_ChIP-Seq_LS180_Human1.46212078
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45703431
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.43380260
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42156434
62P300_19829295_ChIP-Seq_ESCs_Human1.41686216
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40175513
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39245523
65SMC4_20622854_ChIP-Seq_HELA_Human1.38912822
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38052688
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36398432
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36006540
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33965416
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33316506
71KDM2B_26808549_Chip-Seq_DND41_Human1.32122147
72SMAD4_21799915_ChIP-Seq_A2780_Human1.30000864
73P68_20966046_ChIP-Seq_HELA_Human1.28342157
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.27716439
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25840618
76RACK7_27058665_Chip-Seq_MCF-7_Human1.25781145
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24994329
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24309932
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24129523
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24012517
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22770487
82OCT4_19829295_ChIP-Seq_ESCs_Human1.22377849
83FUS_26573619_Chip-Seq_HEK293_Human1.22374308
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22015507
85STAT3_23295773_ChIP-Seq_U87_Human1.21665554
86* PIAS1_25552417_ChIP-Seq_VCAP_Human1.21613333
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21326664
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20716309
89CREB1_26743006_Chip-Seq_LNCaP_Human1.17638656
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.17244692
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16402131
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15546967
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15031240
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11793129
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.10599884
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10560584
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10292869
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09861359
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.09300126
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09261463
101TCF4_23295773_ChIP-Seq_U87_Human1.08999365
102DPY_21335234_ChIP-Seq_ESCs_Mouse1.07532133
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.07436652
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.06275967
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.06160774
106RNF2_27304074_Chip-Seq_NSC_Mouse1.05676957
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.05618387
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05029561
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.04929226
110AHR_22903824_ChIP-Seq_MCF-7_Human1.03573501
111* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03236569
112RING1B_27294783_Chip-Seq_NPCs_Mouse1.02896519
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02841651
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02760765
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02275081
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02043895
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01898755
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01898755
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.01648688
120LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01155022
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00686708
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00422635
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00264789
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99860969
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97714700
126TP53_16413492_ChIP-PET_HCT116_Human0.97683206
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.97614173
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97265571
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.96943395
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.96725303
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95772110
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95718965
133RUNX2_22187159_ChIP-Seq_PCA_Human0.93517349
134SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92823906
135SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92543568
136TP53_20018659_ChIP-ChIP_R1E_Mouse0.92367627
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90944475
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90742248
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90668078
140AR_25329375_ChIP-Seq_VCAP_Human0.90248640
141SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90066566
142P300_18555785_Chip-Seq_ESCs_Mouse0.89890848
143* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89602748
144NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89274986
145EOMES_21245162_ChIP-Seq_HESCs_Human0.89043068
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88622325
147RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88598637
148AR_19668381_ChIP-Seq_PC3_Human0.88554487
149TRIM28_21343339_ChIP-Seq_HEK293_Human0.88418353
150CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87384916
151KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87142242
152* SMAD4_21741376_ChIP-Seq_EPCs_Human0.87131919
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86928114
154GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86805905
155E2F1_18555785_Chip-Seq_ESCs_Mouse0.86479107
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86205747
157NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85717353
158* MITF_21258399_ChIP-Seq_MELANOMA_Human0.85648701
159SA1_27219007_Chip-Seq_ERYTHROID_Human0.85547790
160CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84685839
161MYC_19915707_ChIP-ChIP_AK7_Human0.83870201
162* SMAD4_21741376_ChIP-Seq_ESCs_Human0.83076326
163KLF4_19829295_ChIP-Seq_ESCs_Human0.82730512
164SA1_27219007_Chip-Seq_Bcells_Human0.81271412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.97957933
2MP0004859_abnormal_synaptic_plasticity4.47591047
3MP0000920_abnormal_myelination4.34538576
4MP0004270_analgesia3.72702064
5MP0003635_abnormal_synaptic_transmissio3.00592133
6MP0002272_abnormal_nervous_system2.96641561
7MP0002064_seizures2.94719117
8MP0001486_abnormal_startle_reflex2.84801756
9MP0009745_abnormal_behavioral_response2.75156810
10MP0003690_abnormal_glial_cell2.64410697
11MP0009046_muscle_twitch2.64172723
12MP0001529_abnormal_vocalization2.57830281
13MP0003329_amyloid_beta_deposits2.56639317
14MP0004885_abnormal_endolymph2.50143031
15MP0005423_abnormal_somatic_nervous2.46463504
16MP0005171_absent_coat_pigmentation2.36240490
17MP0002063_abnormal_learning/memory/cond2.29969414
18MP0004742_abnormal_vestibular_system2.23879692
19MP0002822_catalepsy2.21109511
20MP0000778_abnormal_nervous_system2.15827631
21MP0001905_abnormal_dopamine_level2.14234558
22MP0002572_abnormal_emotion/affect_behav2.13608976
23MP0003950_abnormal_plasma_membrane2.12211967
24MP0002734_abnormal_mechanical_nocicepti2.10983956
25MP0004142_abnormal_muscle_tone2.06158287
26MP0003634_abnormal_glial_cell1.95884310
27MP0001485_abnormal_pinna_reflex1.92521600
28MP0001968_abnormal_touch/_nociception1.79699716
29MP0003123_paternal_imprinting1.79494214
30MP0001440_abnormal_grooming_behavior1.78642686
31MP0003136_yellow_coat_color1.76430216
32MP0008569_lethality_at_weaning1.71770155
33MP0002229_neurodegeneration1.69376640
34MP0005409_darkened_coat_color1.65424090
35MP0001970_abnormal_pain_threshold1.64099093
36MP0002067_abnormal_sensory_capabilities1.62920269
37MP0003632_abnormal_nervous_system1.62135077
38MP0000751_myopathy1.61726715
39MP0000955_abnormal_spinal_cord1.60142236
40MP0002882_abnormal_neuron_morphology1.50942548
41MP0004924_abnormal_behavior1.50794044
42MP0005386_behavior/neurological_phenoty1.50794044
43MP0003631_nervous_system_phenotype1.49315657
44MP0003633_abnormal_nervous_system1.46459934
45MP0002733_abnormal_thermal_nociception1.45923753
46MP0002066_abnormal_motor_capabilities/c1.45693729
47MP0003787_abnormal_imprinting1.43378445
48MP0002735_abnormal_chemical_nociception1.43209318
49MP0005410_abnormal_fertilization1.42150868
50MP0002736_abnormal_nociception_after1.37382200
51MP0004043_abnormal_pH_regulation1.37080469
52MP0000749_muscle_degeneration1.36442172
53MP0001501_abnormal_sleep_pattern1.34296793
54MP0005551_abnormal_eye_electrophysiolog1.29246919
55MP0000604_amyloidosis1.26485230
56MP0002184_abnormal_innervation1.19806605
57MP0001963_abnormal_hearing_physiology1.18622053
58MP0010678_abnormal_skin_adnexa1.15443157
59MP0002557_abnormal_social/conspecific_i1.14645830
60MP0000462_abnormal_digestive_system1.13602780
61MP0004381_abnormal_hair_follicle1.11344066
62MP0004145_abnormal_muscle_electrophysio1.10698056
63MP0001177_atelectasis1.07974585
64MP0005623_abnormal_meninges_morphology1.07581118
65MP0000579_abnormal_nail_morphology1.07367692
66MP0004811_abnormal_neuron_physiology1.07126614
67MP0002752_abnormal_somatic_nervous1.06258578
68MP0001299_abnormal_eye_distance/1.04698354
69MP0002152_abnormal_brain_morphology0.99200528
70MP0008260_abnormal_autophagy0.97628933
71MP0000747_muscle_weakness0.97241559
72MP0004134_abnormal_chest_morphology0.96730621
73MP0001346_abnormal_lacrimal_gland0.95536034
74MP0001986_abnormal_taste_sensitivity0.95222179
75MP0000383_abnormal_hair_follicle0.92169478
76MP0005646_abnormal_pituitary_gland0.91597000
77MP0009780_abnormal_chondrocyte_physiolo0.91256966
78MP0004233_abnormal_muscle_weight0.90141250
79MP0004130_abnormal_muscle_cell0.86449012
80MP0005451_abnormal_body_composition0.84969332
81MP0004147_increased_porphyrin_level0.84684765
82MP0001502_abnormal_circadian_rhythm0.83874433
83MP0005645_abnormal_hypothalamus_physiol0.83755578
84MP0000759_abnormal_skeletal_muscle0.80697095
85MP0005167_abnormal_blood-brain_barrier0.77091919
86MP0003938_abnormal_ear_development0.77027944
87MP0005195_abnormal_posterior_eye0.75023037
88MP0002090_abnormal_vision0.74612462
89MP0008874_decreased_physiological_sensi0.72293067
90MP0004087_abnormal_muscle_fiber0.71627343
91MP0000026_abnormal_inner_ear0.70789035
92MP0010234_abnormal_vibrissa_follicle0.70657822
93MP0001188_hyperpigmentation0.69900338
94MP0001984_abnormal_olfaction0.69047839
95MP0003122_maternal_imprinting0.67732284
96MP0006276_abnormal_autonomic_nervous0.67215493
97MP0003137_abnormal_impulse_conducting0.66941269
98MP0005535_abnormal_body_temperature0.66580281
99MP0003075_altered_response_to0.66449689
100MP0003705_abnormal_hypodermis_morpholog0.63158983
101MP0000631_abnormal_neuroendocrine_gland0.62256957
102MP0001661_extended_life_span0.61874663
103MP0002909_abnormal_adrenal_gland0.61590796
104MP0001851_eye_inflammation0.61533178
105MP0002269_muscular_atrophy0.61278513
106MP0004858_abnormal_nervous_system0.60909316
107MP0004085_abnormal_heartbeat0.60714272
108MP0002295_abnormal_pulmonary_circulatio0.59627747
109MP0002069_abnormal_eating/drinking_beha0.59184131
110MP0001348_abnormal_lacrimal_gland0.58771566
111MP0000566_synostosis0.57776807
112MP0002638_abnormal_pupillary_reflex0.57399806
113MP0005253_abnormal_eye_physiology0.56096956
114MP0004036_abnormal_muscle_relaxation0.55802116
115MP0010769_abnormal_survival0.55565915
116MP0006072_abnormal_retinal_apoptosis0.54603844
117MP0000647_abnormal_sebaceous_gland0.54313166
118MP0001943_abnormal_respiration0.53971299
119MP0002249_abnormal_larynx_morphology0.53509077
120MP0001664_abnormal_digestion0.52707643
121MP0009672_abnormal_birth_weight0.51919385
122MP0010768_mortality/aging0.51831601
123MP0003879_abnormal_hair_cell0.51711880
124MP0004510_myositis0.51081829
125MP0003956_abnormal_body_size0.50131388

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.11371550
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.11371550
3Neurofibrillary tangles (HP:0002185)5.79021198
4Myokymia (HP:0002411)4.88763214
5Abnormality of the corticospinal tract (HP:0002492)4.83803398
6Cerebral inclusion bodies (HP:0100314)4.33494511
7Peripheral hypomyelination (HP:0007182)4.33356158
8Focal motor seizures (HP:0011153)4.31995905
9Sensory axonal neuropathy (HP:0003390)4.09958097
10Supranuclear gaze palsy (HP:0000605)4.09587162
11Febrile seizures (HP:0002373)3.96228036
12Diplopia (HP:0000651)3.87339586
13Abnormality of binocular vision (HP:0011514)3.87339586
14Spastic gait (HP:0002064)3.86121614
15Dysmetria (HP:0001310)3.76296000
16Cerebral hypomyelination (HP:0006808)3.68966895
17Parakeratosis (HP:0001036)3.64080025
18Intention tremor (HP:0002080)3.55390749
19Onion bulb formation (HP:0003383)3.53147309
20Termporal pattern (HP:0011008)3.44594408
21Insidious onset (HP:0003587)3.44594408
22Ankle clonus (HP:0011448)3.38814346
23Scanning speech (HP:0002168)3.30487248
24Visual hallucinations (HP:0002367)3.21361870
25Abnormal auditory evoked potentials (HP:0006958)3.21326194
26Annular pancreas (HP:0001734)3.17991784
27Obstructive sleep apnea (HP:0002870)3.16343579
28Focal seizures (HP:0007359)3.10705667
29Alacrima (HP:0000522)2.99442073
30Action tremor (HP:0002345)2.96507061
31Epileptic encephalopathy (HP:0200134)2.93470565
32Bundle branch block (HP:0011710)2.91266172
33Atonic seizures (HP:0010819)2.89335938
34Fetal akinesia sequence (HP:0001989)2.86702466
35Tetraplegia (HP:0002445)2.85544205
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.81598646
37Depression (HP:0000716)2.80476040
38Nemaline bodies (HP:0003798)2.73129092
39Abnormal eating behavior (HP:0100738)2.72205926
40Hyporeflexia of lower limbs (HP:0002600)2.71438671
41Muscle fiber inclusion bodies (HP:0100299)2.70158463
42Insomnia (HP:0100785)2.66792455
43Broad-based gait (HP:0002136)2.65666933
44Akinesia (HP:0002304)2.65096157
45Slow saccadic eye movements (HP:0000514)2.63683114
46Leukodystrophy (HP:0002415)2.61822838
47Torticollis (HP:0000473)2.59960155
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.59795535
49Urinary urgency (HP:0000012)2.59489098
50Retinal dysplasia (HP:0007973)2.57556660
51Poor eye contact (HP:0000817)2.57315785
52Rigidity (HP:0002063)2.52738488
53Lower limb muscle weakness (HP:0007340)2.52545728
54Clumsiness (HP:0002312)2.51102422
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49262359
56Papilledema (HP:0001085)2.48838369
57Gaze-evoked nystagmus (HP:0000640)2.47907435
58Thickened helices (HP:0000391)2.46440204
59Exercise-induced myalgia (HP:0003738)2.44398651
60Dysdiadochokinesis (HP:0002075)2.43957349
61CNS hypomyelination (HP:0003429)2.41870383
62Apathy (HP:0000741)2.38652163
63Delusions (HP:0000746)2.38515490
64Decreased lacrimation (HP:0000633)2.38366353
65Morphological abnormality of the inner ear (HP:0011390)2.37043394
66Hyperventilation (HP:0002883)2.36844591
67Rapidly progressive (HP:0003678)2.35886566
68Pheochromocytoma (HP:0002666)2.34422589
69Myopathic facies (HP:0002058)2.33951280
70Megalencephaly (HP:0001355)2.32839284
71Exercise-induced muscle cramps (HP:0003710)2.31622739
72Hemiplegia (HP:0002301)2.30884134
73Dialeptic seizures (HP:0011146)2.30212938
74Bradykinesia (HP:0002067)2.30156636
75Spastic paraparesis (HP:0002313)2.29056839
76Heart block (HP:0012722)2.27520362
77Anteriorly placed anus (HP:0001545)2.26440266
78Cerebral hemorrhage (HP:0001342)2.24973846
79Hypoplastic pelvis (HP:0008839)2.24588544
80Status epilepticus (HP:0002133)2.21997910
81Increased circulating renin level (HP:0000848)2.21765491
82Urinary bladder sphincter dysfunction (HP:0002839)2.21509610
83Progressive inability to walk (HP:0002505)2.19709067
84Aplasia involving bones of the upper limbs (HP:0009823)2.18397092
85Aplasia of the phalanges of the hand (HP:0009802)2.18397092
86Aplasia involving bones of the extremities (HP:0009825)2.18397092
87Focal dystonia (HP:0004373)2.17899799
88Progressive cerebellar ataxia (HP:0002073)2.16930554
89Abnormal atrioventricular conduction (HP:0005150)2.16358688
90Diminished motivation (HP:0000745)2.15898158
91Split foot (HP:0001839)2.15600350
92Increased serum pyruvate (HP:0003542)2.15382558
93Abnormality of glycolysis (HP:0004366)2.15382558
94Abnormal social behavior (HP:0012433)2.14695753
95Impaired social interactions (HP:0000735)2.14695753
96Turricephaly (HP:0000262)2.13329709
97Epileptiform EEG discharges (HP:0011182)2.12325014
98EMG: myopathic abnormalities (HP:0003458)2.12110753
99Spastic tetraparesis (HP:0001285)2.11815469
100Lower limb amyotrophy (HP:0007210)2.11246751
101Bowel incontinence (HP:0002607)2.09206291
102Clonus (HP:0002169)2.07928490
103Diminished movement (HP:0002374)2.06253254
104Truncal ataxia (HP:0002078)2.06085034
105Absent septum pellucidum (HP:0001331)2.05196078
106Metabolic alkalosis (HP:0200114)2.04987250
107Generalized myoclonic seizures (HP:0002123)2.04723130
108Craniofacial dystonia (HP:0012179)2.03954596
109Neuroendocrine neoplasm (HP:0100634)2.01869705
110Abnormality of the lower motor neuron (HP:0002366)2.01627643
111Generalized tonic-clonic seizures (HP:0002069)2.01477303
112Premature skin wrinkling (HP:0100678)2.00818478
113Segmental peripheral demyelination/remyelination (HP:0003481)2.00265403
114Sleep apnea (HP:0010535)1.98310564
115Impaired vibration sensation in the lower limbs (HP:0002166)1.97311944
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.96603268
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95728426
118Abnormality of saccadic eye movements (HP:0000570)1.95491659
119Foot dorsiflexor weakness (HP:0009027)1.95323932
120Absence seizures (HP:0002121)1.95127975
121Stridor (HP:0010307)1.94800512
122White forelock (HP:0002211)1.90863229
123Decreased motor nerve conduction velocity (HP:0003431)1.90234765
124Abnormal large intestine physiology (HP:0012700)1.90013718
125Autoamputation (HP:0001218)1.89336811
126Congenital ichthyosiform erythroderma (HP:0007431)1.89290096
127Urinary incontinence (HP:0000020)1.89008664
128Morphological abnormality of the pyramidal tract (HP:0002062)1.88297663
129Impaired smooth pursuit (HP:0007772)1.87590167
130Slow progression (HP:0003677)1.87317651
131Poor speech (HP:0002465)1.86608937
132Anxiety (HP:0000739)1.86328765
133EEG with generalized epileptiform discharges (HP:0011198)1.85804032
134Neuronal loss in central nervous system (HP:0002529)1.84975272
135Blue irides (HP:0000635)1.83908095
136Hammertoe (HP:0001765)1.83543258
137Coronal craniosynostosis (HP:0004440)1.82886142
138Hemiparesis (HP:0001269)1.82721558
139Choreoathetosis (HP:0001266)1.82628567
140Patchy hypopigmentation of hair (HP:0011365)1.78825924
141Limb dystonia (HP:0002451)1.78301590
142Distal sensory impairment (HP:0002936)1.78205061
143Cupped ear (HP:0000378)1.78179601
144Abnormality of the foot musculature (HP:0001436)1.76679675
145Mutism (HP:0002300)1.75158613
146Paraparesis (HP:0002385)1.75105554
147Hypoplasia of the iris (HP:0007676)1.73030298
148Postural instability (HP:0002172)1.72491088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.43459357
2OXSR14.07517400
3EPHA42.96918143
4CDK192.58856803
5EPHB12.39597877
6BCR2.33557149
7PKN12.31694695
8TNIK2.28764083
9RIPK12.25563313
10CAMKK12.18532796
11WNK42.09955710
12NTRK32.02039986
13MAPKAPK51.88213850
14FGFR21.87510128
15PAK61.85942021
16UHMK11.84984148
17WNK11.83559443
18NTRK11.82875662
19LATS21.79210626
20PNCK1.72826903
21CASK1.69664941
22PRPF4B1.67271221
23LIMK11.61354148
24CAMK2B1.60826418
25MAP3K91.56586349
26MARK11.55033930
27TESK21.54377058
28TYRO31.53972114
29TESK11.49647356
30TRIB31.47305943
31MET1.47050543
32KSR21.43907716
33NEK61.40587185
34PBK1.38949870
35ICK1.37140106
36FGR1.34038967
37ROCK21.33325844
38CSNK1G31.32839535
39ARAF1.31569075
40DAPK11.29368826
41CSNK1A1L1.29129128
42CAMK2D1.26395160
43SGK2231.24316077
44SGK4941.24316077
45CDK51.22467123
46OBSCN1.19741247
47CSNK1G21.17334769
48PRKD31.14431569
49MAPK121.12514071
50ALK1.09669066
51MAP3K131.07810221
52PINK11.05317670
53CAMK2A1.04457196
54CAMK2G1.02106675
55MINK11.00959774
56NTRK21.00746175
57FES0.97394213
58SGK30.97011734
59DAPK20.96833394
60CDK140.95803124
61CLK10.95010064
62CSNK1G10.94970279
63MST40.92852486
64MAP3K40.92237099
65MAPK130.91263719
66PAK30.89538877
67CDK150.88497565
68BRAF0.88141093
69IRAK20.86974464
70MARK20.85703013
71CDK180.85657176
72MAP3K20.82515625
73PDPK10.80640201
74SGK20.80355686
75STK380.78753113
76CDK11A0.78719193
77PLK20.71032926
78PHKG20.70052183
79PHKG10.70052183
80PRKCE0.70040281
81BRSK10.68741349
82CAMKK20.67888356
83PRKCQ0.67591939
84STK110.64450950
85PRKCH0.64376547
86PTK2B0.64225562
87MUSK0.64205480
88PRKD10.63196038
89MAP2K70.61186411
90CAMK40.60539106
91FYN0.60354836
92EEF2K0.59770851
93MAP3K110.59510700
94MAP2K40.58466233
95KSR10.57754264
96SIK20.57059983
97BMPR20.57053200
98RPS6KA30.56807713
99SCYL20.56533307
100PDK10.54975027
101GRK50.54806000
102PRKCG0.53668337
103CCNB10.51082538
104MAP3K10.49475822
105RIPK40.47690362
106DMPK0.46437500
107NME10.45717374
108MAPKAPK30.45613270
109DYRK20.45572122
110PRKG10.45374948
111CSNK1D0.43791009
112TAOK20.42615133
113SGK10.42169816
114MAP2K10.41589175
115CAMK1G0.41008839
116PRKCZ0.40325367
117DYRK1A0.40319993
118PRKACB0.40242087
119CSNK1A10.39988277
120TNK20.39235632
121ILK0.38195741
122RAF10.37572843
123CAMK10.36968718
124DAPK30.35645334
125ERBB40.35177972
126MAPK100.34659639
127TTN0.34488206
128MAP3K120.34078277
129RPS6KB10.33302996
130RET0.32727045
131PDGFRB0.32650682
132ROCK10.32451297
133PRKACA0.31708183
134BMPR1B0.30991040
135MOS0.30765041

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.06797960
2Fatty acid elongation_Homo sapiens_hsa000622.93178963
3Steroid biosynthesis_Homo sapiens_hsa001002.92877120
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49751737
5Ether lipid metabolism_Homo sapiens_hsa005652.39450267
6Glutamatergic synapse_Homo sapiens_hsa047242.35640442
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30382620
8Nicotine addiction_Homo sapiens_hsa050332.29610565
9GABAergic synapse_Homo sapiens_hsa047272.27628510
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12253505
11Morphine addiction_Homo sapiens_hsa050322.01664561
12Circadian entrainment_Homo sapiens_hsa047131.89442441
13Axon guidance_Homo sapiens_hsa043601.88490411
14Synaptic vesicle cycle_Homo sapiens_hsa047211.87266487
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86280702
16Serotonergic synapse_Homo sapiens_hsa047261.68218138
17Long-term depression_Homo sapiens_hsa047301.68207552
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66664914
19Nitrogen metabolism_Homo sapiens_hsa009101.64733922
20Salivary secretion_Homo sapiens_hsa049701.64592936
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60491709
22Long-term potentiation_Homo sapiens_hsa047201.55789069
23Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.52203807
24Olfactory transduction_Homo sapiens_hsa047401.49589373
25Dopaminergic synapse_Homo sapiens_hsa047281.46965440
26Amphetamine addiction_Homo sapiens_hsa050311.46366366
27Cholinergic synapse_Homo sapiens_hsa047251.42021666
28Gastric acid secretion_Homo sapiens_hsa049711.41610232
29Oxidative phosphorylation_Homo sapiens_hsa001901.40973048
30Collecting duct acid secretion_Homo sapiens_hsa049661.35188804
31Cocaine addiction_Homo sapiens_hsa050301.32894086
32Sulfur metabolism_Homo sapiens_hsa009201.31054352
33Vitamin B6 metabolism_Homo sapiens_hsa007501.29156613
34Sphingolipid metabolism_Homo sapiens_hsa006001.28177718
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19692174
36Renin secretion_Homo sapiens_hsa049241.18236013
37Taste transduction_Homo sapiens_hsa047421.16370563
38Alzheimers disease_Homo sapiens_hsa050101.15307180
39Oocyte meiosis_Homo sapiens_hsa041141.09761212
40Vibrio cholerae infection_Homo sapiens_hsa051101.06652465
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05729419
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05218956
43Cardiac muscle contraction_Homo sapiens_hsa042601.04449634
44Renal cell carcinoma_Homo sapiens_hsa052111.04137334
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04010213
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01653803
47Oxytocin signaling pathway_Homo sapiens_hsa049211.01437739
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00124317
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98877655
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.98789232
51Insulin secretion_Homo sapiens_hsa049110.98733195
52Butanoate metabolism_Homo sapiens_hsa006500.98000373
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.97710334
54Parkinsons disease_Homo sapiens_hsa050120.96634907
55Gap junction_Homo sapiens_hsa045400.96162959
56Calcium signaling pathway_Homo sapiens_hsa040200.95748838
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.93546363
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92877341
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92673346
60VEGF signaling pathway_Homo sapiens_hsa043700.91217343
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89909355
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.89853842
63cAMP signaling pathway_Homo sapiens_hsa040240.89678878
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89675908
65Linoleic acid metabolism_Homo sapiens_hsa005910.88617732
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88390777
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87108800
68Bile secretion_Homo sapiens_hsa049760.85416966
69Circadian rhythm_Homo sapiens_hsa047100.85171883
70ErbB signaling pathway_Homo sapiens_hsa040120.83781336
71Pancreatic secretion_Homo sapiens_hsa049720.82805838
72Phototransduction_Homo sapiens_hsa047440.81944976
73Histidine metabolism_Homo sapiens_hsa003400.81685493
74Glucagon signaling pathway_Homo sapiens_hsa049220.81449784
75Dorso-ventral axis formation_Homo sapiens_hsa043200.79543452
76Ras signaling pathway_Homo sapiens_hsa040140.78943048
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78566181
78beta-Alanine metabolism_Homo sapiens_hsa004100.78316403
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77620567
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77050929
81GnRH signaling pathway_Homo sapiens_hsa049120.76543366
82Tight junction_Homo sapiens_hsa045300.74758354
83Endocytosis_Homo sapiens_hsa041440.73783737
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72032717
85Choline metabolism in cancer_Homo sapiens_hsa052310.67884622
86Protein export_Homo sapiens_hsa030600.67459960
87Insulin signaling pathway_Homo sapiens_hsa049100.66725011
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.65562989
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65206797
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62678427
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62526445
92Arginine biosynthesis_Homo sapiens_hsa002200.59899571
93mTOR signaling pathway_Homo sapiens_hsa041500.59359642
94Ovarian steroidogenesis_Homo sapiens_hsa049130.59276522
95Melanogenesis_Homo sapiens_hsa049160.58057615
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57712627
97AMPK signaling pathway_Homo sapiens_hsa041520.57350457
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57015639
99Arginine and proline metabolism_Homo sapiens_hsa003300.56784576
100Rheumatoid arthritis_Homo sapiens_hsa053230.55632060
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55462755
102Endometrial cancer_Homo sapiens_hsa052130.55352586
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54828131
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52716780
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52206982
106Estrogen signaling pathway_Homo sapiens_hsa049150.51116763
107MAPK signaling pathway_Homo sapiens_hsa040100.50217237
108Autoimmune thyroid disease_Homo sapiens_hsa053200.48410241
109Mineral absorption_Homo sapiens_hsa049780.48283906
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46128656
111Prion diseases_Homo sapiens_hsa050200.45428600
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42856097
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42780882
114Thyroid hormone synthesis_Homo sapiens_hsa049180.42188050
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40515690
116Huntingtons disease_Homo sapiens_hsa050160.40459132
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38886825
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38860249
119Hippo signaling pathway_Homo sapiens_hsa043900.38847476
120Alcoholism_Homo sapiens_hsa050340.38233090
121Dilated cardiomyopathy_Homo sapiens_hsa054140.36813918
122Type II diabetes mellitus_Homo sapiens_hsa049300.36671321
123Wnt signaling pathway_Homo sapiens_hsa043100.36537205
124Non-small cell lung cancer_Homo sapiens_hsa052230.36413776
125Inositol phosphate metabolism_Homo sapiens_hsa005620.35355893
126Rap1 signaling pathway_Homo sapiens_hsa040150.34401962
127Folate biosynthesis_Homo sapiens_hsa007900.33933757
128Phagosome_Homo sapiens_hsa041450.31635369
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31425908
130Chemokine signaling pathway_Homo sapiens_hsa040620.29684770
131Glioma_Homo sapiens_hsa052140.28867053

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