MAP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.83127723
2central nervous system myelination (GO:0022010)9.83127723
3fatty acid elongation (GO:0030497)6.19274464
4ensheathment of neurons (GO:0007272)5.67441457
5axon ensheathment (GO:0008366)5.67441457
6myelination (GO:0042552)5.63537724
7desmosome organization (GO:0002934)4.85157326
8myelin maintenance (GO:0043217)4.73772376
9long-chain fatty acid biosynthetic process (GO:0042759)4.71061994
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.69243209
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.56147197
12L-amino acid import (GO:0043092)4.19812409
13establishment of mitochondrion localization (GO:0051654)4.19753839
14negative regulation of neurotransmitter secretion (GO:0046929)4.17586459
15glutamate secretion (GO:0014047)4.10654856
16negative regulation of neurotransmitter transport (GO:0051589)4.01089007
17apical protein localization (GO:0045176)3.95699839
18photoreceptor cell differentiation (GO:0046530)3.95133687
19eye photoreceptor cell differentiation (GO:0001754)3.95133687
20creatine metabolic process (GO:0006600)3.90630711
21regulation of collateral sprouting (GO:0048670)3.90010569
22cytoskeletal anchoring at plasma membrane (GO:0007016)3.77056275
23asymmetric protein localization (GO:0008105)3.76781700
24response to methylmercury (GO:0051597)3.73416689
25sodium ion export (GO:0071436)3.66306037
26L-alpha-amino acid transmembrane transport (GO:1902475)3.65738655
27glycerophospholipid catabolic process (GO:0046475)3.61506882
28oligodendrocyte differentiation (GO:0048709)3.53016809
29peptidyl-tyrosine autophosphorylation (GO:0038083)3.52767142
30intestinal epithelial cell development (GO:0060576)3.43018277
31presynaptic membrane organization (GO:0097090)3.42948922
32urea cycle (GO:0000050)3.40042296
33long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.33381600
34negative regulation of dendrite morphogenesis (GO:0050774)3.30800807
35regulation of water loss via skin (GO:0033561)3.28759206
36negative regulation of protein localization to cell surface (GO:2000009)3.28684929
37negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.28397879
38cholesterol biosynthetic process (GO:0006695)3.27984349
39multicellular organismal water homeostasis (GO:0050891)3.23356026
40neuronal action potential propagation (GO:0019227)3.23034648
41presynaptic membrane assembly (GO:0097105)3.22787696
42urea metabolic process (GO:0019627)3.21629671
43adult walking behavior (GO:0007628)3.20659634
44protein palmitoylation (GO:0018345)3.12943791
45protein complex localization (GO:0031503)3.12942394
46membrane tubulation (GO:0097320)3.12008316
47transmission of nerve impulse (GO:0019226)3.11911115
48neurotransmitter secretion (GO:0007269)3.11384643
49establishment of skin barrier (GO:0061436)3.09684959
50amyloid precursor protein metabolic process (GO:0042982)3.08856458
51homocysteine metabolic process (GO:0050667)3.08701758
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08232991
53regulation of neuronal synaptic plasticity (GO:0048168)3.06801851
54astrocyte development (GO:0014002)3.06464824
55long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.05745813
56establishment of apical/basal cell polarity (GO:0035089)3.03929409
57negative regulation of hormone metabolic process (GO:0032351)3.03734259
58fatty-acyl-CoA biosynthetic process (GO:0046949)3.01283430
59magnesium ion transport (GO:0015693)2.99874127
60amino acid import (GO:0043090)2.97510833
61synaptic vesicle maturation (GO:0016188)2.96203008
62iron coordination entity transport (GO:1901678)2.94386710
63primary alcohol catabolic process (GO:0034310)2.93566914
64gap junction assembly (GO:0016264)2.93116194
65cellular potassium ion homeostasis (GO:0030007)2.89483255
66negative regulation of inclusion body assembly (GO:0090084)2.89058511
67cell communication involved in cardiac conduction (GO:0086065)2.87834460
68sterol biosynthetic process (GO:0016126)2.87190897
69neuron cell-cell adhesion (GO:0007158)2.86441731
70neuron remodeling (GO:0016322)2.84936795
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84512105
72L-phenylalanine catabolic process (GO:0006559)2.84512105
73potassium ion homeostasis (GO:0055075)2.84330399
74very long-chain fatty acid metabolic process (GO:0000038)2.83334278
75cellular protein complex localization (GO:0034629)2.82351105
76nerve growth factor signaling pathway (GO:0038180)2.81168219
77response to redox state (GO:0051775)2.80383128
78glutathione biosynthetic process (GO:0006750)2.79867054
79tight junction assembly (GO:0070830)2.79645864
80positive regulation of oligodendrocyte differentiation (GO:0048714)2.79214873
81fatty-acyl-CoA metabolic process (GO:0035337)2.78661199
82neuronal ion channel clustering (GO:0045161)2.77530426
83citrulline biosynthetic process (GO:0019240)2.77519335
84substantia nigra development (GO:0021762)2.77492141
85adhesion of symbiont to host cell (GO:0044650)2.77085074
86virion attachment to host cell (GO:0019062)2.77085074
87import into cell (GO:0098657)2.75803897
88nitrogen cycle metabolic process (GO:0071941)2.74766065
89regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74371799
90Golgi to endosome transport (GO:0006895)2.74120823
91regulation of lipoprotein metabolic process (GO:0050746)2.73844228
92regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73841207
93neurotransmitter transport (GO:0006836)2.73739700
94potassium ion import (GO:0010107)2.70826862
95detection of light stimulus involved in visual perception (GO:0050908)2.69239911
96detection of light stimulus involved in sensory perception (GO:0050962)2.69239911
97calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.69137034
98glycine transport (GO:0015816)2.68487706
99regulation of heart rate by cardiac conduction (GO:0086091)2.68303104
100regulation of synaptic vesicle transport (GO:1902803)2.68002051
101cerebellar granule cell differentiation (GO:0021707)2.67934479
102water homeostasis (GO:0030104)2.67331448
103nonribosomal peptide biosynthetic process (GO:0019184)2.65438559
104protein autoprocessing (GO:0016540)2.64903133
105mating behavior (GO:0007617)2.64498016
106synaptic vesicle exocytosis (GO:0016079)2.63322473
107positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.63177223
108biotin metabolic process (GO:0006768)2.63019476
109neuromuscular process controlling posture (GO:0050884)2.62911628
110regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.62581929
111L-phenylalanine metabolic process (GO:0006558)2.57968150
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.57968150
113cell-cell junction assembly (GO:0007043)2.56886099
114toxin transport (GO:1901998)2.55505051
115heme transport (GO:0015886)2.54693314
116neurotransmitter uptake (GO:0001504)2.54662016
117glycosylceramide metabolic process (GO:0006677)2.53472164
118myelination in peripheral nervous system (GO:0022011)2.53370170
119peripheral nervous system axon ensheathment (GO:0032292)2.53370170
120phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.53368038
121regulation of dopamine metabolic process (GO:0042053)2.53152397
122regulation of catecholamine metabolic process (GO:0042069)2.53152397
123axon development (GO:0061564)2.52396821
124neurotransmitter catabolic process (GO:0042135)2.52026423
125negative regulation of axonogenesis (GO:0050771)2.52001209
126thioester biosynthetic process (GO:0035384)2.51113942
127acyl-CoA biosynthetic process (GO:0071616)2.51113942
128regulation of bile acid biosynthetic process (GO:0070857)2.51002058
129ventricular cardiac muscle cell action potential (GO:0086005)2.50635538
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50531178
131mitochondrion transport along microtubule (GO:0047497)2.50531178
132isoprenoid biosynthetic process (GO:0008299)2.49426545
133gamma-aminobutyric acid signaling pathway (GO:0007214)2.48965413
134regulation of synaptic vesicle exocytosis (GO:2000300)2.48500827
135citrulline metabolic process (GO:0000052)2.45944267
136negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.45323681
137peptide biosynthetic process (GO:0043043)2.45206599
138dendritic spine morphogenesis (GO:0060997)2.44316874
139vocalization behavior (GO:0071625)2.44215496
140regulation of voltage-gated calcium channel activity (GO:1901385)2.43779175
141membrane hyperpolarization (GO:0060081)2.43361390
142negative regulation of hormone biosynthetic process (GO:0032353)2.43161360
143positive regulation of action potential (GO:0045760)2.43039491
144cellular glucuronidation (GO:0052695)2.42834734
145glutamine family amino acid biosynthetic process (GO:0009084)2.41944975
146cochlea development (GO:0090102)2.38697948
147regulation of cholesterol biosynthetic process (GO:0045540)2.38003071
148peptidyl-cysteine modification (GO:0018198)2.37985944
149rhodopsin mediated signaling pathway (GO:0016056)2.37539525
150regulation of rhodopsin mediated signaling pathway (GO:0022400)2.36628105
151positive regulation of macroautophagy (GO:0016239)2.36532194
152keratinization (GO:0031424)2.36178590
153nuclear pore complex assembly (GO:0051292)2.35367391
154positive regulation of Rap GTPase activity (GO:0032854)2.33812361
155cardiac conduction (GO:0061337)2.33463816
156pre-miRNA processing (GO:0031054)2.33378169
157hemidesmosome assembly (GO:0031581)2.32699778
158activation of Rac GTPase activity (GO:0032863)2.32159458
159cellular sodium ion homeostasis (GO:0006883)2.31896538
160regulation of neurotransmitter levels (GO:0001505)2.30981323
161zinc ion transmembrane transport (GO:0071577)2.30626739
162uronic acid metabolic process (GO:0006063)2.30099384
163glucuronate metabolic process (GO:0019585)2.30099384
164regulation of translational fidelity (GO:0006450)2.29604156
165chemosensory behavior (GO:0007635)2.28474356
166cardiac muscle cell action potential involved in contraction (GO:0086002)2.26872474
167receptor recycling (GO:0001881)2.26785552
168establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.24468420
169regulation of synaptic plasticity (GO:0048167)2.23761035
170glandular epithelial cell differentiation (GO:0002067)2.23241449
171cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.22852363
172positive regulation of cellular amine metabolic process (GO:0033240)2.21335637
173innervation (GO:0060384)2.19990218
174positive regulation of synapse maturation (GO:0090129)2.19009476
175cell communication by electrical coupling (GO:0010644)2.17879254
176cGMP-mediated signaling (GO:0019934)2.17411099
177vitamin transmembrane transport (GO:0035461)2.17332547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human3.40830893
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.22027298
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.13462304
4GBX2_23144817_ChIP-Seq_PC3_Human2.86048453
5EZH2_22144423_ChIP-Seq_EOC_Human2.59607205
6* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.49837204
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47245939
8AR_21909140_ChIP-Seq_LNCAP_Human2.34274341
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18213085
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16386398
11E2F7_22180533_ChIP-Seq_HELA_Human2.12160650
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.10569975
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04678362
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03962722
15* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.02357376
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.02141155
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99159268
18DROSHA_22980978_ChIP-Seq_HELA_Human1.98562523
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93404774
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.91798261
21TAF15_26573619_Chip-Seq_HEK293_Human1.91433056
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90344821
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.88568827
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85254256
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81161085
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81161085
27VDR_22108803_ChIP-Seq_LS180_Human1.77395467
28GATA6_25053715_ChIP-Seq_YYC3_Human1.72606455
29REST_21632747_ChIP-Seq_MESCs_Mouse1.72473986
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72051917
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.71875537
32FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.71814453
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71709437
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71649749
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71318237
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67281997
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64984321
38SOX2_20726797_ChIP-Seq_SW620_Human1.64877841
39AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.63358005
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.63155306
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63119307
42GATA3_24758297_ChIP-Seq_MCF-7_Human1.62224007
43RACK7_27058665_Chip-Seq_MCF-7_Human1.61962149
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61137505
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.60815178
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60636475
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60080859
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58872475
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54068857
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53466399
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52377188
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51498209
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49736214
54* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49483462
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49392991
56CHD1_26751641_Chip-Seq_LNCaP_Human1.48168666
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47755582
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46736748
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.46248219
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46037600
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.45294641
62AR_21572438_ChIP-Seq_LNCaP_Human1.45233366
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.45014180
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42488763
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.41969758
66FOXA1_25552417_ChIP-Seq_VCAP_Human1.41575508
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39333319
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38161693
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37670415
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37556943
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36385639
72* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36093393
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34811483
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33956475
75CLOCK_20551151_ChIP-Seq_293T_Human1.33063162
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32904930
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32678674
78KLF5_25053715_ChIP-Seq_YYC3_Human1.31223196
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30942506
80* FOXO3_23340844_ChIP-Seq_DLD1_Human1.30641502
81* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29835103
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29431687
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28394790
84CREB1_26743006_Chip-Seq_LNCaP_Human1.28245659
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27702296
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27450005
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25967879
88ER_23166858_ChIP-Seq_MCF-7_Human1.25217052
89MYC_18555785_ChIP-Seq_MESCs_Mouse1.24833456
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22315999
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20341873
92STAT3_23295773_ChIP-Seq_U87_Human1.18515905
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17043009
94KDM2B_26808549_Chip-Seq_K562_Human1.16750052
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16310743
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16269079
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16087697
98* PIAS1_25552417_ChIP-Seq_VCAP_Human1.15866717
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.15817454
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12872683
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12571448
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.12378238
103* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11564532
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.10683810
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10339647
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09620320
107TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09425252
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08901359
109GATA4_25053715_ChIP-Seq_YYC3_Human1.08625292
110KAP1_27257070_Chip-Seq_ESCs_Mouse1.07550083
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06569064
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.06259957
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05873008
114LXR_22158963_ChIP-Seq_LIVER_Mouse1.05628333
115SMAD4_21799915_ChIP-Seq_A2780_Human1.05322410
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05009094
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04946479
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04935160
119BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04086611
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03719458
121POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03589207
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.02995577
123TBL1_22424771_ChIP-Seq_293T_Human1.02150082
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01398168
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.01089362
126CTCF_27219007_Chip-Seq_Bcells_Human1.00865645
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00647252
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00517067
129TCF4_23295773_ChIP-Seq_U87_Human1.00502856
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00082126
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99509340
132AHR_22903824_ChIP-Seq_MCF-7_Human0.99311129
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98804705
134SMC4_20622854_ChIP-Seq_HELA_Human0.98773804
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98620707
136MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98025955
137ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97903986
138HTT_18923047_ChIP-ChIP_STHdh_Human0.97844956
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96983402
140TAL1_26923725_Chip-Seq_HPCs_Mouse0.96788245
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95840400
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95714559
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95530219
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95530219
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.95468196
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94168521
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93722105
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92634010
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92407897
150ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92006667
151RING1B_27294783_Chip-Seq_ESCs_Mouse0.91777244
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91735989
153* P300_19829295_ChIP-Seq_ESCs_Human0.91083141
154* ATF3_27146783_Chip-Seq_COLON_Human0.90860867
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90557975
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90188197
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89377103
158EOMES_21245162_ChIP-Seq_HESCs_Human0.89344834
159FOXA2_19822575_ChIP-Seq_HepG2_Human0.88857554
160EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88544896
161RING1B_27294783_Chip-Seq_NPCs_Mouse0.88354868
162SOX2_21211035_ChIP-Seq_LN229_Gbm0.88168345
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87845226
164FUS_26573619_Chip-Seq_HEK293_Human0.87504280
165MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87454643
166PRDM14_20953172_ChIP-Seq_ESCs_Human0.87418923
167* SMAD4_21741376_ChIP-Seq_EPCs_Human0.87303742
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87049317
169SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85880501
170* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84862539
171TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84847393
172RNF2_27304074_Chip-Seq_NSC_Mouse0.84666140
173EP300_21415370_ChIP-Seq_HL-1_Mouse0.84493833
174NANOG_18555785_Chip-Seq_ESCs_Mouse0.84127539
175CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83925056
176CMYC_18555785_Chip-Seq_ESCs_Mouse0.83392375
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81800558
178TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80703305
179* SMAD3_21741376_ChIP-Seq_HESCs_Human0.80615573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.25725700
2MP0000920_abnormal_myelination4.15591370
3MP0003880_abnormal_central_pattern3.82391385
4MP0004270_analgesia3.61575137
5MP0004885_abnormal_endolymph3.10091930
6MP0004859_abnormal_synaptic_plasticity3.01804297
7MP0009780_abnormal_chondrocyte_physiolo2.80080949
8MP0005551_abnormal_eye_electrophysiolog2.74479139
9MP0004043_abnormal_pH_regulation2.73181470
10MP0003950_abnormal_plasma_membrane2.67616106
11MP0002272_abnormal_nervous_system2.66928657
12MP0003329_amyloid_beta_deposits2.56860107
13MP0001486_abnormal_startle_reflex2.55226237
14MP0003690_abnormal_glial_cell2.54537152
15MP0003941_abnormal_skin_development2.52092763
16MP0001188_hyperpigmentation2.45307209
17MP0002822_catalepsy2.41907052
18MP0002064_seizures2.35614042
19MP0010352_gastrointestinal_tract_polyps2.23980442
20MP0003635_abnormal_synaptic_transmissio2.21761629
21MP0004264_abnormal_extraembryonic_tissu2.17044969
22MP0004742_abnormal_vestibular_system2.16943797
23MP0005410_abnormal_fertilization2.16853790
24MP0002229_neurodegeneration2.15523942
25MP0005423_abnormal_somatic_nervous2.14030628
26MP0001485_abnormal_pinna_reflex2.11234295
27MP0001529_abnormal_vocalization2.10045876
28MP0003123_paternal_imprinting2.08101388
29MP0009745_abnormal_behavioral_response2.00460531
30MP0009046_muscle_twitch1.94947504
31MP0010678_abnormal_skin_adnexa1.91746962
32MP0003634_abnormal_glial_cell1.89913150
33MP0005501_abnormal_skin_physiology1.84909782
34MP0001905_abnormal_dopamine_level1.84684786
35MP0000462_abnormal_digestive_system1.79312611
36MP0006072_abnormal_retinal_apoptosis1.77429470
37MP0004142_abnormal_muscle_tone1.77363973
38MP0002734_abnormal_mechanical_nocicepti1.77160132
39MP0005409_darkened_coat_color1.71781224
40MP0008057_abnormal_DNA_replication1.71028943
41MP0002139_abnormal_hepatobiliary_system1.67819297
42MP0002063_abnormal_learning/memory/cond1.63155889
43MP0000383_abnormal_hair_follicle1.62119991
44MP0000778_abnormal_nervous_system1.61643834
45MP0003136_yellow_coat_color1.60315718
46MP0002572_abnormal_emotion/affect_behav1.57733605
47MP0002098_abnormal_vibrissa_morphology1.57708955
48MP0005253_abnormal_eye_physiology1.54650415
49MP0008569_lethality_at_weaning1.53525474
50MP0009672_abnormal_birth_weight1.51074289
51MP0000678_abnormal_parathyroid_gland1.50835025
52MP0000537_abnormal_urethra_morphology1.50593152
53MP0004782_abnormal_surfactant_physiolog1.49897339
54MP0003453_abnormal_keratinocyte_physiol1.44745386
55MP0001440_abnormal_grooming_behavior1.44732793
56MP0003632_abnormal_nervous_system1.44730218
57MP0005171_absent_coat_pigmentation1.44657906
58MP0002882_abnormal_neuron_morphology1.44499045
59MP0004019_abnormal_vitamin_homeostasis1.43390388
60MP0002909_abnormal_adrenal_gland1.42516276
61MP0003633_abnormal_nervous_system1.41064694
62MP0003879_abnormal_hair_cell1.40389154
63MP0003195_calcinosis1.39679870
64MP0009379_abnormal_foot_pigmentation1.37521597
65MP0003693_abnormal_embryo_hatching1.36566095
66MP0003631_nervous_system_phenotype1.35560752
67MP0000955_abnormal_spinal_cord1.33729599
68MP0002009_preneoplasia1.30691766
69MP0004957_abnormal_blastocyst_morpholog1.30550893
70MP0002067_abnormal_sensory_capabilities1.29344064
71MP0005195_abnormal_posterior_eye1.28813895
72MP0001346_abnormal_lacrimal_gland1.25713220
73MP0003787_abnormal_imprinting1.24166302
74MP0002066_abnormal_motor_capabilities/c1.24088929
75MP0001970_abnormal_pain_threshold1.22071494
76MP0000377_abnormal_hair_follicle1.21571480
77MP0001502_abnormal_circadian_rhythm1.21516447
78MP0002752_abnormal_somatic_nervous1.20960799
79MP0005386_behavior/neurological_phenoty1.20798348
80MP0004924_abnormal_behavior1.20798348
81MP0004185_abnormal_adipocyte_glucose1.17844194
82MP0005451_abnormal_body_composition1.17363154
83MP0008260_abnormal_autophagy1.15305995
84MP0001963_abnormal_hearing_physiology1.12876195
85MP0004381_abnormal_hair_follicle1.12836148
86MP0003806_abnormal_nucleotide_metabolis1.12236521
87MP0005365_abnormal_bile_salt1.10591236
88MP0010771_integument_phenotype1.10038533
89MP0000604_amyloidosis1.06580910
90MP0003011_delayed_dark_adaptation1.05481302
91MP0002090_abnormal_vision1.05263782
92MP0003183_abnormal_peptide_metabolism1.05151833
93MP0002733_abnormal_thermal_nociception1.04576024
94MP0003718_maternal_effect1.03284505
95MP0008877_abnormal_DNA_methylation1.03120635
96MP0001968_abnormal_touch/_nociception1.02828721
97MP0002254_reproductive_system_inflammat1.01960866
98MP0003890_abnormal_embryonic-extraembry1.01822186
99MP0000747_muscle_weakness1.00166917
100MP0001216_abnormal_epidermal_layer1.00070762
101MP0004147_increased_porphyrin_level0.99857181
102MP0000627_abnormal_mammary_gland0.99327648
103MP0001501_abnormal_sleep_pattern0.98574874
104MP0002876_abnormal_thyroid_physiology0.97952314
105MP0002396_abnormal_hematopoietic_system0.95204527
106MP0000579_abnormal_nail_morphology0.90790629
107MP0000647_abnormal_sebaceous_gland0.90740858
108MP0001666_abnormal_nutrient_absorption0.89400704
109MP0001661_extended_life_span0.88725196
110MP0005076_abnormal_cell_differentiation0.83702907
111MP0005636_abnormal_mineral_homeostasis0.83323913
112MP0002152_abnormal_brain_morphology0.82751322
113MP0001730_embryonic_growth_arrest0.82153021
114MP0001765_abnormal_ion_homeostasis0.81751662
115MP0004145_abnormal_muscle_electrophysio0.81507427
116MP0001984_abnormal_olfaction0.81369794
117MP0003698_abnormal_male_reproductive0.80687245
118MP0009840_abnormal_foam_cell0.80437209
119MP0009703_decreased_birth_body0.80416925
120MP0000566_synostosis0.80296871
121MP0002160_abnormal_reproductive_system0.79789677
122MP0005360_urolithiasis0.79165647
123MP0002557_abnormal_social/conspecific_i0.77704305
124MP0008875_abnormal_xenobiotic_pharmacok0.77359180
125MP0001177_atelectasis0.75398534
126MP0000467_abnormal_esophagus_morphology0.75138994
127MP0002796_impaired_skin_barrier0.74240679
128MP0005646_abnormal_pituitary_gland0.74023498
129MP0001944_abnormal_pancreas_morphology0.73137213
130MP0002735_abnormal_chemical_nociception0.72660575
131MP0005085_abnormal_gallbladder_physiolo0.72544567
132MP0003283_abnormal_digestive_organ0.71696842
133MP0005666_abnormal_adipose_tissue0.71504128
134MP0005332_abnormal_amino_acid0.71147697
135MP0000003_abnormal_adipose_tissue0.70872393
136MP0002184_abnormal_innervation0.70610875
137MP0001849_ear_inflammation0.70320684
138MP0004811_abnormal_neuron_physiology0.70142902
139MP0003868_abnormal_feces_composition0.69019244
140MP0005391_vision/eye_phenotype0.68623691
141MP0002118_abnormal_lipid_homeostasis0.67836748
142MP0005220_abnormal_exocrine_pancreas0.67328562
143MP0000477_abnormal_intestine_morphology0.67121134
144MP0001664_abnormal_digestion0.66431243
145MP0004036_abnormal_muscle_relaxation0.65321984
146MP0001731_abnormal_postnatal_growth0.64876624
147MP0000762_abnormal_tongue_morphology0.64404981
148MP0001881_abnormal_mammary_gland0.64392055
149MP0000350_abnormal_cell_proliferation0.63669016
150MP0005645_abnormal_hypothalamus_physiol0.63647897
151MP0002736_abnormal_nociception_after0.62900411
152MP0001299_abnormal_eye_distance/0.62297459

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.49835387
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.49835387
3Neurofibrillary tangles (HP:0002185)5.44961302
4Abnormality of the corticospinal tract (HP:0002492)4.27155159
5Peripheral hypomyelination (HP:0007182)4.26465813
6Right ventricular cardiomyopathy (HP:0011663)4.15632372
7Cerebral inclusion bodies (HP:0100314)3.97841829
8Myokymia (HP:0002411)3.97825427
9Pili torti (HP:0003777)3.88871082
10Onion bulb formation (HP:0003383)3.75264019
11Supranuclear gaze palsy (HP:0000605)3.69420081
12Intention tremor (HP:0002080)3.65892358
13Spastic gait (HP:0002064)3.64395354
14Parakeratosis (HP:0001036)3.51698840
15Ankle clonus (HP:0011448)3.48269121
16Dysmetria (HP:0001310)3.46847930
17Cerebral hypomyelination (HP:0006808)3.45785438
18Sensory axonal neuropathy (HP:0003390)3.33316591
19Hyperactive renin-angiotensin system (HP:0000841)3.33138024
20Increased circulating renin level (HP:0000848)3.31353870
21Metabolic alkalosis (HP:0200114)3.12068607
22Chronic bronchitis (HP:0004469)3.09304030
23Abnormal auditory evoked potentials (HP:0006958)3.05789654
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.99177082
25Scanning speech (HP:0002168)2.95321780
26Hypoglycemic seizures (HP:0002173)2.92601393
27Alacrima (HP:0000522)2.91253906
28Congenital stationary night blindness (HP:0007642)2.90824375
29Dysmetric saccades (HP:0000641)2.82698975
30Insidious onset (HP:0003587)2.78747067
31Termporal pattern (HP:0011008)2.78747067
32Hypokalemic alkalosis (HP:0001949)2.73639443
33Abolished electroretinogram (ERG) (HP:0000550)2.68282044
34Focal motor seizures (HP:0011153)2.62133280
35Hypomagnesemia (HP:0002917)2.61243473
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.58382114
37Retinal dysplasia (HP:0007973)2.57344261
38Clumsiness (HP:0002312)2.56685603
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56202111
40Abnormal hair laboratory examination (HP:0003328)2.55730106
41Slow saccadic eye movements (HP:0000514)2.55303130
42Lip pit (HP:0100267)2.54883391
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51574655
44Segmental peripheral demyelination/remyelination (HP:0003481)2.50727947
45Action tremor (HP:0002345)2.48060442
46Spastic paraparesis (HP:0002313)2.44845588
47Clonus (HP:0002169)2.44607182
48CNS hypomyelination (HP:0003429)2.44081335
49Spastic tetraparesis (HP:0001285)2.42427560
50Hyperinsulinemic hypoglycemia (HP:0000825)2.42262628
51Dysdiadochokinesis (HP:0002075)2.41910284
52Hypoglycemic coma (HP:0001325)2.40200580
53Urethral obstruction (HP:0000796)2.39742371
54Anteriorly placed anus (HP:0001545)2.39227297
55Split foot (HP:0001839)2.37001190
56Abnormality of macular pigmentation (HP:0008002)2.33134458
57Bronchomalacia (HP:0002780)2.31126705
58Abnormality of permanent molar morphology (HP:0011071)2.27819466
59Abnormality of the dental root (HP:0006486)2.27819466
60Taurodontia (HP:0000679)2.27819466
61Thickened helices (HP:0000391)2.25895559
62Hyperphosphatemia (HP:0002905)2.24994451
63Abnormality of nail color (HP:0100643)2.24813937
64Lower limb muscle weakness (HP:0007340)2.24336509
65Symptomatic seizures (HP:0011145)2.22742158
66Decreased lacrimation (HP:0000633)2.21191377
67Hyperaldosteronism (HP:0000859)2.20705922
68Central scotoma (HP:0000603)2.19941924
69Leukodystrophy (HP:0002415)2.19599124
70Absent septum pellucidum (HP:0001331)2.13936510
71Hypoplasia of dental enamel (HP:0006297)2.11806441
72Epileptic encephalopathy (HP:0200134)2.11123317
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10328161
74Impaired vibration sensation in the lower limbs (HP:0002166)2.09975841
75Abnormality of chloride homeostasis (HP:0011422)2.09500348
76Alkalosis (HP:0001948)2.08601520
77Megalencephaly (HP:0001355)2.07009043
78Premature skin wrinkling (HP:0100678)2.06626007
79Amelogenesis imperfecta (HP:0000705)2.05296439
80Congenital ichthyosiform erythroderma (HP:0007431)2.05234392
81Pheochromocytoma (HP:0002666)2.04674106
82Morphological abnormality of the inner ear (HP:0011390)2.04463861
83Septate vagina (HP:0001153)2.04019938
84Aplasia involving bones of the upper limbs (HP:0009823)2.03447646
85Aplasia of the phalanges of the hand (HP:0009802)2.03447646
86Aplasia involving bones of the extremities (HP:0009825)2.03447646
87Decreased central vision (HP:0007663)2.03365144
88Akinesia (HP:0002304)2.02686122
89Abnormality of vitamin metabolism (HP:0100508)2.01643849
90Ankyloglossia (HP:0010296)2.00653885
91Plantar hyperkeratosis (HP:0007556)2.00247816
92Onycholysis (HP:0001806)1.98948992
93Abnormality of the dental pulp (HP:0006479)1.98536920
94Abnormality of magnesium homeostasis (HP:0004921)1.98206728
95Choreoathetosis (HP:0001266)1.97311829
96Hyperkalemia (HP:0002153)1.93026813
97Bowel incontinence (HP:0002607)1.93012275
98Urinary bladder sphincter dysfunction (HP:0002839)1.92848947
99Abnormality of molar morphology (HP:0011070)1.92340313
100Abnormality of molar (HP:0011077)1.92340313
101Axonal loss (HP:0003447)1.92116248
102Postural instability (HP:0002172)1.91010702
103Palmoplantar hyperkeratosis (HP:0000972)1.90517168
104Morphological abnormality of the pyramidal tract (HP:0002062)1.89921458
105Curly hair (HP:0002212)1.88948386
106Focal seizures (HP:0007359)1.88057150
107Abnormality of the gastric mucosa (HP:0004295)1.87315664
108Poor speech (HP:0002465)1.87313242
109Paraparesis (HP:0002385)1.87166339
110Decreased motor nerve conduction velocity (HP:0003431)1.86994394
111Macroorchidism (HP:0000053)1.86008160
112Intrahepatic cholestasis (HP:0001406)1.85420160
113Gaze-evoked nystagmus (HP:0000640)1.83229237
114Tetraplegia (HP:0002445)1.82540693
115Confusion (HP:0001289)1.82364752
116Hammertoe (HP:0001765)1.81819459
117Esophageal atresia (HP:0002032)1.81694512
118Bony spicule pigmentary retinopathy (HP:0007737)1.81334778
119Urinary urgency (HP:0000012)1.80955401
120Cerebral hemorrhage (HP:0001342)1.80382561
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.80241526
122Absent/shortened dynein arms (HP:0200106)1.80241526
123Multiple enchondromatosis (HP:0005701)1.79588858
124Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79533273
125Abnormality of the salivary glands (HP:0010286)1.79340973
126Septo-optic dysplasia (HP:0100842)1.77487526
127Palmar hyperkeratosis (HP:0010765)1.77408265
128Abnormality of the septum pellucidum (HP:0007375)1.77050684
129Hyperparathyroidism (HP:0000843)1.77038567
130Foot dorsiflexor weakness (HP:0009027)1.76878225
131Papillary thyroid carcinoma (HP:0002895)1.76442502
132Impaired vibratory sensation (HP:0002495)1.75920912
133Methylmalonic acidemia (HP:0002912)1.75746623
134Abnormal rod and cone electroretinograms (HP:0008323)1.75666176
135Distal sensory impairment (HP:0002936)1.75386549
136Abnormal cartilage morphology (HP:0002763)1.75356508
137Vaginal atresia (HP:0000148)1.74515789
138Autoamputation (HP:0001218)1.74503868
139Abnormality of renin-angiotensin system (HP:0000847)1.73044686
140Hypoplastic labia majora (HP:0000059)1.72957415
141Abnormal large intestine physiology (HP:0012700)1.72386156
142Renal salt wasting (HP:0000127)1.71047088
143Keratoconus (HP:0000563)1.70888314
144Increased corneal curvature (HP:0100692)1.70888314
145Broad-based gait (HP:0002136)1.70575425
146Ileus (HP:0002595)1.70176606
147Overriding aorta (HP:0002623)1.70126185
148Polydipsia (HP:0001959)1.69765543
149Abnormal drinking behavior (HP:0030082)1.69765543
150Epileptiform EEG discharges (HP:0011182)1.69504455
151Abnormality of saccadic eye movements (HP:0000570)1.69230798
152Selective tooth agenesis (HP:0001592)1.68143042
153Megaloblastic anemia (HP:0001889)1.67513580
154Urinary incontinence (HP:0000020)1.66618761
155Hyperammonemia (HP:0001987)1.65968474
156Flat acetabular roof (HP:0003180)1.65758206
157Obstructive sleep apnea (HP:0002870)1.64853290
158Absent eyelashes (HP:0000561)1.64841610
159Bifid scrotum (HP:0000048)1.63200262
160Gout (HP:0001997)1.61319659
161Ventricular fibrillation (HP:0001663)1.57732246
162Fat malabsorption (HP:0002630)1.57542988
163Sparse eyelashes (HP:0000653)1.56819818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.09357797
2OXSR14.54169064
3MST1R3.71712100
4EPHA23.16668629
5WNK43.02541057
6EPHB12.81834933
7EEF2K2.73482194
8FGFR22.43488273
9MAPKAPK52.41602330
10PNCK2.35640344
11EPHA42.22261319
12MET2.19155750
13WNK12.16870281
14PKN12.09334272
15BCR2.00234119
16CDK192.00213231
17RIPK11.95908433
18TNIK1.94965342
19RPS6KB21.88279128
20TTK1.87556588
21CDK121.84897157
22LATS21.82209049
23NTRK11.79809141
24SMG11.70477116
25SCYL21.68555514
26ICK1.68082177
27PAK61.65818243
28UHMK11.64478111
29STK241.62888238
30PBK1.58803932
31PRKG21.58791098
32PRPF4B1.57304539
33NEK61.57239584
34CAMK2B1.55605989
35SGK2231.50673387
36SGK4941.50673387
37CAMK1D1.48473456
38ALK1.46416721
39MKNK11.41421640
40CAMK2D1.38685356
41MAPK151.37837031
42PRKD31.37807793
43CSNK1G31.36208509
44MAP3K121.34639782
45CSNK1A1L1.34451469
46DAPK11.30771655
47TSSK61.29826164
48TYRO31.27877366
49LMTK21.24813466
50KSR21.18097840
51ACVR1B1.17342003
52CSNK1G21.14021813
53LIMK11.13347954
54CSNK1G11.12461237
55MAP3K91.11473020
56PINK11.10131902
57ROCK21.06982651
58MAP3K21.06379762
59FER1.06177291
60NTRK31.02997067
61CAMK2G1.02772787
62CDC71.01863830
63CDK51.01580975
64PAK31.00187858
65MKNK21.00175564
66MARK20.97873105
67WNK30.97610993
68LATS10.95145054
69FGR0.92710536
70TAF10.91460658
71MARK10.90505075
72STK38L0.90502686
73ARAF0.88156421
74NME20.88036228
75CAMK2A0.87778088
76PRKCI0.86172817
77PDPK10.86133497
78SGK20.83456537
79PRKD10.83444466
80SGK30.82436701
81PHKG10.81263233
82PHKG20.81263233
83CASK0.77706707
84CLK10.77675253
85MAP3K130.75651992
86STK110.75438184
87CDK140.72092789
88MAP2K20.71951952
89TRIB30.70817079
90PTK20.68929052
91GRK10.68451383
92TESK20.68026169
93STK30.67827138
94PRKD20.66839926
95SIK10.66714900
96MAP3K40.66153961
97NME10.66073493
98MAPKAPK30.65994940
99BMX0.65279702
100CDK150.65128053
101NTRK20.62511957
102RPS6KB10.62015400
103PDK10.59810311
104MUSK0.58972898
105CDK180.57791540
106CDK11A0.57662104
107PRKCQ0.57282224
108PRKCE0.56749100
109BRAF0.56060443
110MTOR0.54891213
111IRAK20.54508560
112CDK60.52996342
113PRKCH0.52301972
114BRSK20.51844541
115CSNK1D0.51701636
116CAMK1G0.51647545
117FES0.51510813
118MST40.50326791
119CSNK1A10.49827153
120GSK3B0.46895035
121FGFR10.46710322
122FYN0.46417983
123AKT20.46331310
124PRKG10.46167292
125CSNK1E0.45961934
126MAP3K10.45804274
127HIPK20.45747838
128PRKACB0.44780833
129INSRR0.44701671
130AKT30.44362342
131MAPK100.44142607
132NLK0.43073582
133CAMKK10.42799849
134GSK3A0.41792468
135BMPR20.41673391
136CDK20.41438187
137SGK10.40982166
138MINK10.40903871
139BRSK10.39065009
140TAOK10.38710347
141PIK3CA0.37291398
142PDK20.36978037
143DYRK1A0.36734450
144YES10.36471339
145PRKDC0.36105094
146DAPK20.35667311
147MAPK130.35420900
148PRKACA0.35392118
149RPS6KA50.34858184
150CDK30.33854172
151PTK2B0.33626686
152PRKCG0.30801563
153RPS6KA30.30518943

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.44963722
2Fatty acid elongation_Homo sapiens_hsa000623.19036152
3Nitrogen metabolism_Homo sapiens_hsa009102.94660749
4Steroid biosynthesis_Homo sapiens_hsa001002.78627006
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61188880
6Ether lipid metabolism_Homo sapiens_hsa005652.40111096
7Arginine biosynthesis_Homo sapiens_hsa002202.28160714
8Sulfur metabolism_Homo sapiens_hsa009202.17423837
9Vitamin B6 metabolism_Homo sapiens_hsa007502.13805793
10Phototransduction_Homo sapiens_hsa047442.13688666
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09556270
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97169975
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95181889
14GABAergic synapse_Homo sapiens_hsa047271.92583345
15Butanoate metabolism_Homo sapiens_hsa006501.78868665
16Glutamatergic synapse_Homo sapiens_hsa047241.71182107
17Histidine metabolism_Homo sapiens_hsa003401.69984254
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58109121
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57862874
20Linoleic acid metabolism_Homo sapiens_hsa005911.52943825
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48828397
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46590972
23Morphine addiction_Homo sapiens_hsa050321.46291704
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36742108
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36527609
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36201917
27Nicotine addiction_Homo sapiens_hsa050331.35920206
28Synaptic vesicle cycle_Homo sapiens_hsa047211.35230424
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.34619386
30Phenylalanine metabolism_Homo sapiens_hsa003601.31847114
31Circadian entrainment_Homo sapiens_hsa047131.31095909
32Serotonergic synapse_Homo sapiens_hsa047261.29280226
33Salivary secretion_Homo sapiens_hsa049701.28052475
34Sphingolipid metabolism_Homo sapiens_hsa006001.25530125
35Arginine and proline metabolism_Homo sapiens_hsa003301.19541476
36Mineral absorption_Homo sapiens_hsa049781.18299505
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15141952
38Thyroid hormone synthesis_Homo sapiens_hsa049181.14271422
39Axon guidance_Homo sapiens_hsa043601.13996241
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.11525528
41Gastric acid secretion_Homo sapiens_hsa049711.10253209
42Selenocompound metabolism_Homo sapiens_hsa004501.10076211
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09379205
44Glucagon signaling pathway_Homo sapiens_hsa049221.07455112
45Retinol metabolism_Homo sapiens_hsa008301.07353218
46Long-term depression_Homo sapiens_hsa047301.07034476
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06633765
48Insulin secretion_Homo sapiens_hsa049111.06041606
49Chemical carcinogenesis_Homo sapiens_hsa052041.06038376
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.03529980
51Cocaine addiction_Homo sapiens_hsa050301.02978527
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01890867
53Amphetamine addiction_Homo sapiens_hsa050311.00548255
54Olfactory transduction_Homo sapiens_hsa047401.00303093
55Pancreatic secretion_Homo sapiens_hsa049720.99604153
56Dopaminergic synapse_Homo sapiens_hsa047280.98469624
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96375245
58Collecting duct acid secretion_Homo sapiens_hsa049660.94153475
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.93496046
60Propanoate metabolism_Homo sapiens_hsa006400.93372888
61Biosynthesis of amino acids_Homo sapiens_hsa012300.92754896
62Thyroid cancer_Homo sapiens_hsa052160.92089747
63Folate biosynthesis_Homo sapiens_hsa007900.89714811
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89556490
65Tight junction_Homo sapiens_hsa045300.87587200
66Vitamin digestion and absorption_Homo sapiens_hsa049770.87502194
67Long-term potentiation_Homo sapiens_hsa047200.86761896
68Cholinergic synapse_Homo sapiens_hsa047250.86656647
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85129662
70Bile secretion_Homo sapiens_hsa049760.84290341
71Fatty acid metabolism_Homo sapiens_hsa012120.83587635
72Renin secretion_Homo sapiens_hsa049240.82683491
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82165788
74Starch and sucrose metabolism_Homo sapiens_hsa005000.81477577
75Taste transduction_Homo sapiens_hsa047420.80222870
76Fatty acid biosynthesis_Homo sapiens_hsa000610.79637343
77Oxidative phosphorylation_Homo sapiens_hsa001900.77918141
78Dorso-ventral axis formation_Homo sapiens_hsa043200.77571719
79Caffeine metabolism_Homo sapiens_hsa002320.77253080
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77009487
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74329922
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.74193487
83Renal cell carcinoma_Homo sapiens_hsa052110.74073827
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.73503758
85Glycerolipid metabolism_Homo sapiens_hsa005610.73211238
86Cardiac muscle contraction_Homo sapiens_hsa042600.71210238
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69850353
88ABC transporters_Homo sapiens_hsa020100.68998414
89Vibrio cholerae infection_Homo sapiens_hsa051100.68560917
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68078468
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68030385
92Carbon metabolism_Homo sapiens_hsa012000.67838492
93Protein export_Homo sapiens_hsa030600.66417916
94Oocyte meiosis_Homo sapiens_hsa041140.65273975
95Tyrosine metabolism_Homo sapiens_hsa003500.64462158
96Estrogen signaling pathway_Homo sapiens_hsa049150.63731869
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63249626
98Fatty acid degradation_Homo sapiens_hsa000710.62756962
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.61772499
100Fructose and mannose metabolism_Homo sapiens_hsa000510.61312315
101Alzheimers disease_Homo sapiens_hsa050100.61063041
102Circadian rhythm_Homo sapiens_hsa047100.60796109
103Adherens junction_Homo sapiens_hsa045200.60726717
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59947013
105Gap junction_Homo sapiens_hsa045400.59912876
106Glutathione metabolism_Homo sapiens_hsa004800.59903698
107Renin-angiotensin system_Homo sapiens_hsa046140.59845148
108Choline metabolism in cancer_Homo sapiens_hsa052310.59716618
109Peroxisome_Homo sapiens_hsa041460.58984925
110Endocytosis_Homo sapiens_hsa041440.58335002
111Inositol phosphate metabolism_Homo sapiens_hsa005620.58005947
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57569966
113Fat digestion and absorption_Homo sapiens_hsa049750.57190127
114Pyruvate metabolism_Homo sapiens_hsa006200.56982317
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56474921
116Pentose phosphate pathway_Homo sapiens_hsa000300.55799265
117GnRH signaling pathway_Homo sapiens_hsa049120.55140794
118cAMP signaling pathway_Homo sapiens_hsa040240.54941722
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.54098774
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54041780
121ErbB signaling pathway_Homo sapiens_hsa040120.53873624
122Oxytocin signaling pathway_Homo sapiens_hsa049210.53168769
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53138324
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52646991
125mRNA surveillance pathway_Homo sapiens_hsa030150.52061500
126Ras signaling pathway_Homo sapiens_hsa040140.50261741
127Arachidonic acid metabolism_Homo sapiens_hsa005900.49581403
128Ovarian steroidogenesis_Homo sapiens_hsa049130.49047126
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48568744
130Galactose metabolism_Homo sapiens_hsa000520.48508268
131Calcium signaling pathway_Homo sapiens_hsa040200.48227333
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.47722720
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46713877
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45790639
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45635412
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45340213
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.45130840
138beta-Alanine metabolism_Homo sapiens_hsa004100.44634333

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