MAP7D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.75417382
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38479001
3synaptic vesicle exocytosis (GO:0016079)5.37509508
4neuronal action potential propagation (GO:0019227)5.34574414
5regulation of meiosis I (GO:0060631)5.09085770
6vocalization behavior (GO:0071625)4.98591345
7neuron cell-cell adhesion (GO:0007158)4.96923040
8synapsis (GO:0007129)4.96762886
9glutamate secretion (GO:0014047)4.88372012
10synaptic vesicle maturation (GO:0016188)4.85445197
11regulation of synaptic vesicle exocytosis (GO:2000300)4.75487748
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70002902
13protein localization to synapse (GO:0035418)4.50976803
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50607430
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46084664
16locomotory exploration behavior (GO:0035641)4.44457532
17positive regulation of meiosis (GO:0045836)4.40464449
18chromosome organization involved in meiosis (GO:0070192)4.36330109
19male meiosis I (GO:0007141)4.35695445
20synaptonemal complex assembly (GO:0007130)4.31621230
21neurotransmitter secretion (GO:0007269)4.26433795
22neurofilament cytoskeleton organization (GO:0060052)4.22985152
23regulation of synaptic vesicle transport (GO:1902803)4.21812325
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.21163111
25positive regulation of meiotic cell cycle (GO:0051446)4.13405702
26regulation of glutamate receptor signaling pathway (GO:1900449)4.08540456
27DNA methylation involved in gamete generation (GO:0043046)4.08449557
28synaptonemal complex organization (GO:0070193)4.07381432
29negative regulation of dendrite morphogenesis (GO:0050774)4.01979639
30positive regulation of dendritic spine morphogenesis (GO:0061003)3.98407475
31exploration behavior (GO:0035640)3.94512178
32cerebellar granule cell differentiation (GO:0021707)3.93475892
33glutamate receptor signaling pathway (GO:0007215)3.89766779
34regulation of neuronal synaptic plasticity (GO:0048168)3.80527978
35neuromuscular process controlling posture (GO:0050884)3.80465378
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.78589867
37neuron-neuron synaptic transmission (GO:0007270)3.76644652
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74825171
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.74112177
40synaptic transmission, glutamatergic (GO:0035249)3.70955067
41neurotransmitter transport (GO:0006836)3.70846488
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.70323376
43potassium ion homeostasis (GO:0055075)3.67332587
44transmission of nerve impulse (GO:0019226)3.67081878
45positive regulation of dendritic spine development (GO:0060999)3.67020094
46proline transport (GO:0015824)3.65110116
47neuron recognition (GO:0008038)3.63045750
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58330243
49gamma-aminobutyric acid transport (GO:0015812)3.58171514
50regulation of long-term neuronal synaptic plasticity (GO:0048169)3.58120935
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.57976244
52male meiosis (GO:0007140)3.56066930
53cell migration in hindbrain (GO:0021535)3.55847999
54dopamine biosynthetic process (GO:0042416)3.52225626
55cellular potassium ion homeostasis (GO:0030007)3.50145199
56potassium ion import (GO:0010107)3.49482359
57cerebellar Purkinje cell differentiation (GO:0021702)3.47755606
58presynaptic membrane assembly (GO:0097105)3.43061536
59layer formation in cerebral cortex (GO:0021819)3.39867158
60prepulse inhibition (GO:0060134)3.39663122
61regulation of neurotransmitter levels (GO:0001505)3.38845259
62dopamine transport (GO:0015872)3.34046532
63regulation of voltage-gated calcium channel activity (GO:1901385)3.32683563
64presynaptic membrane organization (GO:0097090)3.32062155
65meiosis I (GO:0007127)3.31300702
66cellular sodium ion homeostasis (GO:0006883)3.31128391
67synaptic vesicle endocytosis (GO:0048488)3.30424343
68membrane depolarization during action potential (GO:0086010)3.28793206
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28335236
70serotonin metabolic process (GO:0042428)3.23209870
71regulation of vesicle fusion (GO:0031338)3.20510521
72positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19841851
73detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.19838818
74detection of temperature stimulus involved in sensory perception (GO:0050961)3.19838818
75negative regulation of dendrite development (GO:2000171)3.18979013
76central nervous system myelination (GO:0022010)3.17910570
77axon ensheathment in central nervous system (GO:0032291)3.17910570
78regulation of synapse structural plasticity (GO:0051823)3.17756361
79regulation of postsynaptic membrane potential (GO:0060078)3.17057864
80neurotransmitter-gated ion channel clustering (GO:0072578)3.15880879
81innervation (GO:0060384)3.15805990
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14691552
83regulation of synaptic plasticity (GO:0048167)3.13593429
84regulation of neurotransmitter secretion (GO:0046928)3.13157299
85long-term memory (GO:0007616)3.12870878
86calcium-mediated signaling using intracellular calcium source (GO:0035584)3.12780220
87cochlea development (GO:0090102)3.12475176
88response to amphetamine (GO:0001975)3.12021044
89positive regulation of neurotransmitter transport (GO:0051590)3.11403608
90mating behavior (GO:0007617)3.10922220
91positive regulation of membrane potential (GO:0045838)3.10338383
92long-term synaptic potentiation (GO:0060291)3.10173513
93axonal fasciculation (GO:0007413)3.09960731
94detection of calcium ion (GO:0005513)3.09886111
95vesicle transport along microtubule (GO:0047496)3.09606190
96postsynaptic membrane organization (GO:0001941)3.08791233
97activation of protein kinase A activity (GO:0034199)3.08266645
98regulation of synaptic transmission, glutamatergic (GO:0051966)3.06116606
99synapse assembly (GO:0007416)3.05908661
100behavioral response to cocaine (GO:0048148)3.05482566
101neuromuscular process controlling balance (GO:0050885)3.04435596
102organelle transport along microtubule (GO:0072384)3.03514790
103regulation of synapse maturation (GO:0090128)3.02649639
104detection of temperature stimulus (GO:0016048)3.02416591
105L-amino acid import (GO:0043092)3.02095507
106membrane depolarization (GO:0051899)3.01905285
107adult walking behavior (GO:0007628)3.01326063
108cerebellar Purkinje cell layer development (GO:0021680)3.00735032
109regulation of dendritic spine development (GO:0060998)2.98810517
110positive regulation of potassium ion transmembrane transport (GO:1901381)2.98163555
111regulation of glutamate secretion (GO:0014048)2.97799078
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97407896
113regulation of protein kinase A signaling (GO:0010738)2.97347861
114synaptic transmission (GO:0007268)2.97122974
115regulation of dopamine metabolic process (GO:0042053)2.96933923
116regulation of catecholamine metabolic process (GO:0042069)2.96933923
117neuromuscular synaptic transmission (GO:0007274)2.94734129
118cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.94561252
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94408737
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94372135
121meiotic nuclear division (GO:0007126)2.94015831
122negative regulation of neurotransmitter transport (GO:0051589)2.93672408
123positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93303341
124regulation of neurotransmitter transport (GO:0051588)2.92900071
125establishment of mitochondrion localization (GO:0051654)2.92865016
126positive regulation of neurotransmitter secretion (GO:0001956)2.91712780
127catecholamine transport (GO:0051937)2.91105389
128sodium ion export (GO:0071436)2.90191532
129regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90189126
130membrane hyperpolarization (GO:0060081)2.88095867
131neuromuscular process (GO:0050905)2.87647451
132establishment of synaptic vesicle localization (GO:0097480)2.86339077
133synaptic vesicle transport (GO:0048489)2.86339077
134axon cargo transport (GO:0008088)2.86170068
135response to histamine (GO:0034776)2.85894719
136dendritic spine morphogenesis (GO:0060997)2.85483962
137calcium ion-dependent exocytosis (GO:0017156)2.84986692
138positive regulation of synapse maturation (GO:0090129)2.84836703
139negative regulation of microtubule polymerization (GO:0031115)2.82890627
140neuronal ion channel clustering (GO:0045161)2.81829706
141regulation of dendritic spine morphogenesis (GO:0061001)2.81014373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83791517
2GBX2_23144817_ChIP-Seq_PC3_Human3.75712122
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19849804
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12792984
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07693522
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68196345
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68196345
8REST_21632747_ChIP-Seq_MESCs_Mouse2.66210306
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63760976
10TAF15_26573619_Chip-Seq_HEK293_Human2.62345776
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58740087
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52334842
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49141914
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46758150
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.45066546
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44849620
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.28750167
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.15210007
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13540824
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.13019178
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.10200341
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.10113447
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03501031
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01278167
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97294995
26DROSHA_22980978_ChIP-Seq_HELA_Human1.96722559
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90918223
28AR_21572438_ChIP-Seq_LNCaP_Human1.90858149
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84947192
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83599826
31SMAD4_21799915_ChIP-Seq_A2780_Human1.82424490
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80935814
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79449836
34IGF1R_20145208_ChIP-Seq_DFB_Human1.70767651
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.70277050
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68386938
37P300_19829295_ChIP-Seq_ESCs_Human1.64508193
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58521280
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57513899
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57014474
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46974242
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46827535
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44280351
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43879649
45ZNF274_21170338_ChIP-Seq_K562_Hela1.42824598
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42371411
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42311883
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39753339
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38595074
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.38362540
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.38362507
52RNF2_27304074_Chip-Seq_NSC_Mouse1.37363137
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36953953
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.34802424
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33727648
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33647243
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.33282148
58STAT3_23295773_ChIP-Seq_U87_Human1.32587596
59AR_25329375_ChIP-Seq_VCAP_Human1.32579286
60VDR_22108803_ChIP-Seq_LS180_Human1.30192195
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.29508328
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27731839
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26684025
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25794885
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.24250978
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19954437
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18901686
68FUS_26573619_Chip-Seq_HEK293_Human1.16357858
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.15982638
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15936090
71CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15789075
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12118227
73TCF4_23295773_ChIP-Seq_U87_Human1.11842525
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.08707157
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08039706
76AR_19668381_ChIP-Seq_PC3_Human1.08017118
77* RUNX2_22187159_ChIP-Seq_PCA_Human1.07159138
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.06966654
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06779008
80ER_23166858_ChIP-Seq_MCF-7_Human1.05799578
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04785289
82JUN_21703547_ChIP-Seq_K562_Human1.04742781
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.04430657
84HTT_18923047_ChIP-ChIP_STHdh_Human1.03609176
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02332998
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02089395
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.01881424
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01494454
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99361876
90AHR_22903824_ChIP-Seq_MCF-7_Human0.99042260
91BCAT_22108803_ChIP-Seq_LS180_Human0.98316849
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98275910
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97228215
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.96479781
95RING1B_27294783_Chip-Seq_NPCs_Mouse0.96045699
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95062726
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.94928481
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93860550
99SOX9_26525672_Chip-Seq_HEART_Mouse0.93277686
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93218583
101YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93095737
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91823239
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91023335
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90977554
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89512226
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88843447
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88494311
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87304119
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87207355
110TP53_18474530_ChIP-ChIP_U2OS_Human0.87154231
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.85969652
112KDM2B_26808549_Chip-Seq_REH_Human0.85773368
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84877492
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84877492
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.83992745
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83879826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.18116411
2MP0004859_abnormal_synaptic_plasticity5.13407017
3MP0008877_abnormal_DNA_methylation3.91553554
4MP0004270_analgesia3.90386737
5MP0003635_abnormal_synaptic_transmissio3.74407363
6MP0009046_muscle_twitch3.41199130
7MP0002735_abnormal_chemical_nociception3.35657755
8MP0001968_abnormal_touch/_nociception3.34048989
9MP0009745_abnormal_behavioral_response3.18212354
10MP0002064_seizures3.07421057
11MP0002063_abnormal_learning/memory/cond2.90422122
12MP0002734_abnormal_mechanical_nocicepti2.88248174
13MP0002736_abnormal_nociception_after2.84975191
14MP0006276_abnormal_autonomic_nervous2.83599129
15MP0002272_abnormal_nervous_system2.81206261
16MP0002572_abnormal_emotion/affect_behav2.63937881
17MP0005423_abnormal_somatic_nervous2.56796544
18MP0001486_abnormal_startle_reflex2.47346841
19MP0002733_abnormal_thermal_nociception2.44058900
20MP0001970_abnormal_pain_threshold2.28143736
21MP0001501_abnormal_sleep_pattern2.26969816
22MP0001440_abnormal_grooming_behavior2.23953502
23MP0002067_abnormal_sensory_capabilities2.21637294
24MP0004858_abnormal_nervous_system2.15003710
25MP0002184_abnormal_innervation2.02553761
26MP0003329_amyloid_beta_deposits1.97213283
27MP0003123_paternal_imprinting1.88617794
28MP0002822_catalepsy1.78952259
29MP0004142_abnormal_muscle_tone1.76486099
30MP0004924_abnormal_behavior1.75290898
31MP0005386_behavior/neurological_phenoty1.75290898
32MP0000778_abnormal_nervous_system1.73365374
33MP0008569_lethality_at_weaning1.73156714
34MP0001529_abnormal_vocalization1.73091161
35MP0000955_abnormal_spinal_cord1.68557437
36MP0002557_abnormal_social/conspecific_i1.65029607
37MP0004811_abnormal_neuron_physiology1.62678803
38MP0001905_abnormal_dopamine_level1.60117230
39MP0001188_hyperpigmentation1.55624036
40MP0002882_abnormal_neuron_morphology1.46901645
41MP0001984_abnormal_olfaction1.46278294
42MP0002066_abnormal_motor_capabilities/c1.44877501
43MP0005646_abnormal_pituitary_gland1.41779802
44MP0009780_abnormal_chondrocyte_physiolo1.41352675
45MP0003122_maternal_imprinting1.34570214
46MP0002909_abnormal_adrenal_gland1.34473949
47MP0005645_abnormal_hypothalamus_physiol1.33838918
48MP0003879_abnormal_hair_cell1.28716248
49MP0004885_abnormal_endolymph1.26804078
50MP0004145_abnormal_muscle_electrophysio1.25552121
51MP0002229_neurodegeneration1.25479218
52MP0004742_abnormal_vestibular_system1.24744195
53MP0003633_abnormal_nervous_system1.23481909
54MP0002210_abnormal_sex_determination1.21270608
55MP0003121_genomic_imprinting1.20415764
56MP0001502_abnormal_circadian_rhythm1.15174286
57MP0000920_abnormal_myelination1.11487673
58MP0002160_abnormal_reproductive_system1.11102526
59MP0001986_abnormal_taste_sensitivity1.10579761
60MP0000751_myopathy1.10525726
61MP0003631_nervous_system_phenotype1.09589499
62MP0003787_abnormal_imprinting1.08820263
63MP0003698_abnormal_male_reproductive1.06853846
64MP0001963_abnormal_hearing_physiology1.05850342
65MP0002837_dystrophic_cardiac_calcinosis1.05100113
66MP0000566_synostosis1.02485012
67MP0001929_abnormal_gametogenesis1.02320033
68MP0003634_abnormal_glial_cell1.01702093
69MP0002752_abnormal_somatic_nervous0.98428334
70MP0002152_abnormal_brain_morphology0.98423165
71MP0001485_abnormal_pinna_reflex0.94246362
72MP0008872_abnormal_physiological_respon0.91763391
73MP0005551_abnormal_eye_electrophysiolog0.90769168
74MP0000604_amyloidosis0.87208598
75MP0000653_abnormal_sex_gland0.85032655
76MP0000569_abnormal_digit_pigmentation0.84290829
77MP0003632_abnormal_nervous_system0.83185490
78MP0005535_abnormal_body_temperature0.83049371
79MP0005171_absent_coat_pigmentation0.82886255
80MP0001145_abnormal_male_reproductive0.82662944
81MP0002751_abnormal_autonomic_nervous0.82470461
82MP0002876_abnormal_thyroid_physiology0.82433027
83MP0002069_abnormal_eating/drinking_beha0.81596990
84MP0008874_decreased_physiological_sensi0.80538159
85MP0010386_abnormal_urinary_bladder0.80389425
86MP0004085_abnormal_heartbeat0.79851841
87MP0003690_abnormal_glial_cell0.78750236
88MP0001348_abnormal_lacrimal_gland0.78125711
89MP0004147_increased_porphyrin_level0.76255732
90MP0002161_abnormal_fertility/fecundity0.74761828
91MP0000013_abnormal_adipose_tissue0.73506622
92MP0005409_darkened_coat_color0.73490067
93MP0005623_abnormal_meninges_morphology0.72049896
94MP0001299_abnormal_eye_distance/0.70274650
95MP0002638_abnormal_pupillary_reflex0.70187319
96MP0005394_taste/olfaction_phenotype0.68998384
97MP0005499_abnormal_olfactory_system0.68998384
98MP0004484_altered_response_of0.68787722
99MP0004215_abnormal_myocardial_fiber0.68699051
100MP0001346_abnormal_lacrimal_gland0.68043338
101MP0001664_abnormal_digestion0.67966597
102MP0006035_abnormal_mitochondrial_morpho0.67547721
103MP0000631_abnormal_neuroendocrine_gland0.66338992
104MP0002090_abnormal_vision0.65690819
105MP0000026_abnormal_inner_ear0.63802886
106MP0002089_abnormal_postnatal_growth/wei0.63443866
107MP0000639_abnormal_adrenal_gland0.63223510
108MP0005410_abnormal_fertilization0.60957679
109MP0000747_muscle_weakness0.60705939
110MP0001177_atelectasis0.60467254
111MP0003137_abnormal_impulse_conducting0.59611552
112MP0001943_abnormal_respiration0.59377998
113MP0008058_abnormal_DNA_repair0.57956542
114MP0005389_reproductive_system_phenotype0.55598233
115MP0003283_abnormal_digestive_organ0.53758007
116MP0001944_abnormal_pancreas_morphology0.52738749
117MP0003183_abnormal_peptide_metabolism0.52519688
118MP0004036_abnormal_muscle_relaxation0.49933090
119MP0006072_abnormal_retinal_apoptosis0.49658184
120MP0003861_abnormal_nervous_system0.48373254
121MP0010769_abnormal_survival0.48180254
122MP0010770_preweaning_lethality0.47823022

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.57073352
2Myokymia (HP:0002411)6.74371868
3Atonic seizures (HP:0010819)5.41877816
4Focal seizures (HP:0007359)5.41665692
5Febrile seizures (HP:0002373)4.82398880
6Visual hallucinations (HP:0002367)4.67848426
7Epileptic encephalopathy (HP:0200134)4.42893076
8Progressive cerebellar ataxia (HP:0002073)4.39131150
9Absence seizures (HP:0002121)4.30635582
10Action tremor (HP:0002345)4.12548008
11Supranuclear gaze palsy (HP:0000605)3.99424714
12Dialeptic seizures (HP:0011146)3.96560775
13Generalized tonic-clonic seizures (HP:0002069)3.83364334
14Ulnar claw (HP:0001178)3.68443578
15Pheochromocytoma (HP:0002666)3.49542682
16Termporal pattern (HP:0011008)3.21388642
17Insidious onset (HP:0003587)3.21388642
18Neuroendocrine neoplasm (HP:0100634)3.15529456
19Ankle clonus (HP:0011448)3.12375107
20Gaze-evoked nystagmus (HP:0000640)3.07787146
21Truncal ataxia (HP:0002078)3.05013525
22Hyperventilation (HP:0002883)2.97684675
23Dysmetria (HP:0001310)2.94316557
24Amblyopia (HP:0000646)2.89673151
25Abnormality of the corticospinal tract (HP:0002492)2.86842703
26Progressive inability to walk (HP:0002505)2.86203916
27Dysdiadochokinesis (HP:0002075)2.85614261
28Scanning speech (HP:0002168)2.84301929
29Broad-based gait (HP:0002136)2.83530138
30Impaired vibration sensation in the lower limbs (HP:0002166)2.78847996
31Abnormal eating behavior (HP:0100738)2.77791946
32Urinary bladder sphincter dysfunction (HP:0002839)2.72704408
33Spastic gait (HP:0002064)2.72102938
34Anxiety (HP:0000739)2.72090149
35Depression (HP:0000716)2.69710667
36Limb dystonia (HP:0002451)2.69059385
37Peripheral hypomyelination (HP:0007182)2.66662818
38Urinary urgency (HP:0000012)2.65755868
39Morphological abnormality of the pyramidal tract (HP:0002062)2.63694799
40Neurofibrillary tangles (HP:0002185)2.62990199
41Focal dystonia (HP:0004373)2.61031035
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.60816948
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.60816948
44Cerebral inclusion bodies (HP:0100314)2.52508885
45Cerebral hypomyelination (HP:0006808)2.47371632
46Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.43731349
47Horizontal nystagmus (HP:0000666)2.42322309
48Fetal akinesia sequence (HP:0001989)2.36598411
49Hemiparesis (HP:0001269)2.36201451
50Rigidity (HP:0002063)2.34246678
51Mutism (HP:0002300)2.33190863
52Failure to thrive in infancy (HP:0001531)2.33188416
53Postural instability (HP:0002172)2.32938872
54Poor eye contact (HP:0000817)2.32547860
55Dysmetric saccades (HP:0000641)2.32372447
56Dyskinesia (HP:0100660)2.31330658
57Bradykinesia (HP:0002067)2.28369594
58Abnormal social behavior (HP:0012433)2.26793881
59Impaired social interactions (HP:0000735)2.26793881
60Delusions (HP:0000746)2.25778374
61Inability to walk (HP:0002540)2.25596732
62Postural tremor (HP:0002174)2.24341711
63Abnormality of ocular smooth pursuit (HP:0000617)2.23024953
64Excessive salivation (HP:0003781)2.22512665
65Drooling (HP:0002307)2.22512665
66Craniofacial dystonia (HP:0012179)2.21199130
67Lower limb muscle weakness (HP:0007340)2.20618187
68Amyotrophic lateral sclerosis (HP:0007354)2.19337605
69Spontaneous abortion (HP:0005268)2.18178398
70Osteomalacia (HP:0002749)2.14349601
71Epileptiform EEG discharges (HP:0011182)2.13382448
72Retinal dysplasia (HP:0007973)2.13183506
73Diminished movement (HP:0002374)2.13118537
74Absent speech (HP:0001344)2.12494095
75Volvulus (HP:0002580)2.12079884
76Abnormality of saccadic eye movements (HP:0000570)2.11537478
77Abnormality of binocular vision (HP:0011514)2.10670699
78Diplopia (HP:0000651)2.10670699
79Polyphagia (HP:0002591)2.10127989
80Genetic anticipation (HP:0003743)2.09934361
81Choreoathetosis (HP:0001266)2.08465824
82Abnormal hair whorl (HP:0010721)2.08124614
83Gait imbalance (HP:0002141)2.05935917
84Hammertoe (HP:0001765)2.05633961
85EEG with generalized epileptiform discharges (HP:0011198)2.05113890
86Steppage gait (HP:0003376)2.03507125
87Neuronal loss in central nervous system (HP:0002529)2.03471291
88Muscular hypotonia of the trunk (HP:0008936)2.03422722
89Impaired smooth pursuit (HP:0007772)2.03261315
90Generalized myoclonic seizures (HP:0002123)2.00916478
91Ventricular fibrillation (HP:0001663)2.00647739
92Akinesia (HP:0002304)2.00116523
93Hypokinesia (HP:0002375)1.99962664
94Intention tremor (HP:0002080)1.99929118
95Incomplete penetrance (HP:0003829)1.98328524
96Neoplasm of the peripheral nervous system (HP:0100007)1.97932249
97Status epilepticus (HP:0002133)1.97431176
98Abnormality of aromatic amino acid family metabolism (HP:0004338)1.96516869
99CNS hypomyelination (HP:0003429)1.95495761
100Hypobetalipoproteinemia (HP:0003563)1.95398430
101Genital tract atresia (HP:0001827)1.93045774
102Agnosia (HP:0010524)1.92738209
103Psychosis (HP:0000709)1.92263232
104Hypsarrhythmia (HP:0002521)1.92109999
105Oligodactyly (hands) (HP:0001180)1.90995874
106Hemiplegia (HP:0002301)1.90909005
107Specific learning disability (HP:0001328)1.89823737
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89392028
109Acute necrotizing encephalopathy (HP:0006965)1.89228437
110Vaginal atresia (HP:0000148)1.88581797
111Annular pancreas (HP:0001734)1.88570813
112Impaired vibratory sensation (HP:0002495)1.87728152
113Sleep apnea (HP:0010535)1.87406635
114Hypoventilation (HP:0002791)1.87098947
115Esotropia (HP:0000565)1.85536785
116Onion bulb formation (HP:0003383)1.85404772
117Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84881051
118Gait ataxia (HP:0002066)1.83869844
119Foot dorsiflexor weakness (HP:0009027)1.83614889
120Abnormality of pain sensation (HP:0010832)1.82228144
121Impaired pain sensation (HP:0007328)1.82228144
122Tetraplegia (HP:0002445)1.81460579
123Progressive macrocephaly (HP:0004481)1.81048897
124Torticollis (HP:0000473)1.80789602
125Agitation (HP:0000713)1.80786220
126Poor suck (HP:0002033)1.80378688
127Decreased motor nerve conduction velocity (HP:0003431)1.78975244
128Gonadotropin excess (HP:0000837)1.78768027
129Hyperthyroidism (HP:0000836)1.78118447
130Blue irides (HP:0000635)1.78088656
131Abnormality of the lower motor neuron (HP:0002366)1.77643897
132Increased circulating renin level (HP:0000848)1.77355790
133Papilledema (HP:0001085)1.74375492
134Clonus (HP:0002169)1.65031039
135Intellectual disability, profound (HP:0002187)1.62916301
136Dysarthria (HP:0001260)1.60374670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.56969178
2MAP3K43.25756920
3MAP3K93.23937220
4MINK13.17227456
5CASK3.13092832
6EPHA42.90815261
7MAP3K122.86747584
8MAP2K72.82355181
9NTRK12.43011488
10PNCK2.42672714
11MARK12.27317109
12MAP2K42.21127518
13KSR21.96233145
14PAK61.92877210
15RIPK41.79194556
16ARAF1.76332804
17GRK51.64933272
18NTRK21.54789485
19STK391.53177364
20PLK21.52387767
21CDK191.51512452
22DAPK21.48413942
23LMTK21.47240825
24MAPK131.46852760
25LATS21.42909232
26CDK51.38429692
27OXSR11.31710499
28TNIK1.28484486
29WNK11.25878925
30PRKCG1.22585654
31FES1.21976146
32ACVR1B1.20521515
33PHKG21.17677222
34PHKG11.17677222
35CAMKK11.17359849
36KSR11.16324939
37CAMK2A1.12332230
38UHMK11.06745236
39MAP3K21.06355625
40CAMKK21.04984056
41FRK1.03894824
42PDK21.02773369
43AKT31.01532782
44SGK2231.00407703
45SGK4941.00407703
46DAPK10.98155431
47STK380.95595928
48GRK70.94656855
49TNK20.94215934
50LIMK10.91280646
51WNK40.90761529
52BRSK10.88312995
53CSNK1G10.87689451
54CSNK1G20.86490626
55CAMK2B0.86295443
56PRPF4B0.84980924
57CDK140.83035648
58PTK2B0.81531720
59PRKD30.80713587
60RET0.80261979
61FGFR20.79645923
62CDK180.78925055
63FER0.77806228
64MAP3K130.77661410
65BMPR20.77009415
66NME10.75415448
67CDK150.75322883
68PINK10.74630697
69CAMK2G0.72830765
70SIK20.72212352
71SGK20.71923273
72PAK30.69560175
73BCR0.69227908
74PRKCE0.68624421
75BRAF0.67244778
76FGR0.66750934
77RAF10.66747533
78CDK11A0.65102738
79CAMK2D0.63361159
80MAPKAPK50.63117537
81ROCK20.62600706
82MUSK0.62420349
83STK110.62372035
84TYRO30.61271111
85MAP3K110.60111845
86MAP3K10.58215112
87MAP2K10.57404590
88SCYL20.56781876
89CAMK10.56307838
90ADRBK10.55290884
91DYRK1A0.53572793
92CSNK1G30.53384787
93PRKCH0.53213725
94PDPK10.51917546
95SGK10.51192105
96PRKG10.49337004
97PKN10.46815544
98MET0.46562582
99WNK30.45875709
100MAPK100.45449348
101BUB10.45104609
102ADRBK20.44960299
103CSNK1E0.43892981
104PDK10.43859860
105TTK0.42819860
106SGK30.42106287
107CAMK1G0.40666508
108RPS6KA30.40498805
109NEK60.39587166
110PRKACA0.39535540
111CSNK1D0.39516876
112MARK20.38746186
113CSNK1A1L0.38647479
114PRKCZ0.38335048
115PRKCA0.38036963
116MAP2K60.37470082
117PRKACB0.35739569
118CSNK1A10.33832549
119CDK30.32034124

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88733608
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69290232
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69898583
4GABAergic synapse_Homo sapiens_hsa047272.64819118
5Olfactory transduction_Homo sapiens_hsa047402.50018163
6Long-term potentiation_Homo sapiens_hsa047202.49994642
7Circadian entrainment_Homo sapiens_hsa047132.42904703
8Glutamatergic synapse_Homo sapiens_hsa047242.38533022
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36893716
10Morphine addiction_Homo sapiens_hsa050322.32275703
11Amphetamine addiction_Homo sapiens_hsa050312.32010676
12Collecting duct acid secretion_Homo sapiens_hsa049662.26063548
13Dopaminergic synapse_Homo sapiens_hsa047282.17253705
14Taste transduction_Homo sapiens_hsa047422.16818427
15Salivary secretion_Homo sapiens_hsa049702.04689650
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.92101894
17Serotonergic synapse_Homo sapiens_hsa047261.89211442
18Insulin secretion_Homo sapiens_hsa049111.84693482
19Long-term depression_Homo sapiens_hsa047301.78826529
20Gastric acid secretion_Homo sapiens_hsa049711.75234106
21Oxidative phosphorylation_Homo sapiens_hsa001901.72352377
22Cholinergic synapse_Homo sapiens_hsa047251.71786860
23Renin secretion_Homo sapiens_hsa049241.62591033
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52681403
25Calcium signaling pathway_Homo sapiens_hsa040201.49959941
26Cocaine addiction_Homo sapiens_hsa050301.49787162
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46497640
28Cardiac muscle contraction_Homo sapiens_hsa042601.46243474
29Oxytocin signaling pathway_Homo sapiens_hsa049211.43484550
30Vibrio cholerae infection_Homo sapiens_hsa051101.38548791
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36755431
32Parkinsons disease_Homo sapiens_hsa050121.34731682
33Alzheimers disease_Homo sapiens_hsa050101.34226448
34GnRH signaling pathway_Homo sapiens_hsa049121.33605446
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28661135
36Gap junction_Homo sapiens_hsa045401.28291069
37Vitamin B6 metabolism_Homo sapiens_hsa007501.25006032
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.22701389
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15548525
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14140248
41Folate biosynthesis_Homo sapiens_hsa007901.11977695
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.09552593
43cAMP signaling pathway_Homo sapiens_hsa040241.09062260
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07088814
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05823228
46Axon guidance_Homo sapiens_hsa043601.04805109
47Phototransduction_Homo sapiens_hsa047440.99836874
48Estrogen signaling pathway_Homo sapiens_hsa049150.99440842
49Dorso-ventral axis formation_Homo sapiens_hsa043200.99109412
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98772820
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97681229
52ErbB signaling pathway_Homo sapiens_hsa040120.95325954
53Melanogenesis_Homo sapiens_hsa049160.93940764
54Oocyte meiosis_Homo sapiens_hsa041140.91651492
55Huntingtons disease_Homo sapiens_hsa050160.91187424
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.90299060
57Type II diabetes mellitus_Homo sapiens_hsa049300.89767051
58Glioma_Homo sapiens_hsa052140.84821095
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81260741
60Nitrogen metabolism_Homo sapiens_hsa009100.79472745
61Pancreatic secretion_Homo sapiens_hsa049720.76908351
62Mineral absorption_Homo sapiens_hsa049780.76515592
63Thyroid hormone synthesis_Homo sapiens_hsa049180.68585257
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.68217326
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67323275
66MAPK signaling pathway_Homo sapiens_hsa040100.64161500
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62493988
68Butanoate metabolism_Homo sapiens_hsa006500.61920040
69Choline metabolism in cancer_Homo sapiens_hsa052310.61245534
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56843534
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56092484
72Ras signaling pathway_Homo sapiens_hsa040140.55302505
73Rheumatoid arthritis_Homo sapiens_hsa053230.51605236
74Arginine and proline metabolism_Homo sapiens_hsa003300.51538278
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50571434
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50269635
77Inositol phosphate metabolism_Homo sapiens_hsa005620.50215205
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.50148640
79beta-Alanine metabolism_Homo sapiens_hsa004100.50096835
80Dilated cardiomyopathy_Homo sapiens_hsa054140.49836008
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.48664852
82Glucagon signaling pathway_Homo sapiens_hsa049220.48106312
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45213798
84Prion diseases_Homo sapiens_hsa050200.44100145
85Type I diabetes mellitus_Homo sapiens_hsa049400.43190893
86Alcoholism_Homo sapiens_hsa050340.43131957
87Endocytosis_Homo sapiens_hsa041440.43047228
88VEGF signaling pathway_Homo sapiens_hsa043700.42087970
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40469474
90Phagosome_Homo sapiens_hsa041450.40375908
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39728552
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39679011
93Fatty acid elongation_Homo sapiens_hsa000620.38927558
94Rap1 signaling pathway_Homo sapiens_hsa040150.38852166
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38379820
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35536386
97mTOR signaling pathway_Homo sapiens_hsa041500.35379408
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35263210
99Renal cell carcinoma_Homo sapiens_hsa052110.35205445
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34973540
101Fatty acid biosynthesis_Homo sapiens_hsa000610.33533913
102Wnt signaling pathway_Homo sapiens_hsa043100.33393223
103Bile secretion_Homo sapiens_hsa049760.32745449
104Circadian rhythm_Homo sapiens_hsa047100.32320140
105Histidine metabolism_Homo sapiens_hsa003400.32057141
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31956600
107Insulin signaling pathway_Homo sapiens_hsa049100.31744290
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.30837326
109Ether lipid metabolism_Homo sapiens_hsa005650.30207632
110Regulation of autophagy_Homo sapiens_hsa041400.29706554
111Ovarian steroidogenesis_Homo sapiens_hsa049130.29006434
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28682453
113Melanoma_Homo sapiens_hsa052180.28637996
114African trypanosomiasis_Homo sapiens_hsa051430.28281360
115ABC transporters_Homo sapiens_hsa020100.26732821
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26438613
117Glycerolipid metabolism_Homo sapiens_hsa005610.25971084
118Sphingolipid metabolism_Homo sapiens_hsa006000.25441599
119Arginine biosynthesis_Homo sapiens_hsa002200.21990751
120Propanoate metabolism_Homo sapiens_hsa006400.17784465

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