MAPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.49234258
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.32393192
3locomotory exploration behavior (GO:0035641)6.31112695
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.99004470
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.59684992
6synaptic vesicle exocytosis (GO:0016079)5.58039417
7glutamate secretion (GO:0014047)5.42170291
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.41489796
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32052445
10vocalization behavior (GO:0071625)5.22641999
11regulation of glutamate receptor signaling pathway (GO:1900449)5.14976812
12regulation of synaptic vesicle exocytosis (GO:2000300)5.12823678
13negative regulation of amyloid precursor protein catabolic process (GO:1902992)5.09905995
14negative regulation of erythrocyte differentiation (GO:0045647)4.95547481
15exploration behavior (GO:0035640)4.90910528
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.90482181
17regulation of synapse structural plasticity (GO:0051823)4.83111853
18layer formation in cerebral cortex (GO:0021819)4.82398207
19regulation of neuronal synaptic plasticity (GO:0048168)4.74766359
20nuclear pore complex assembly (GO:0051292)4.70765259
21protein localization to synapse (GO:0035418)4.66435982
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.62939432
23regulation of synaptic vesicle transport (GO:1902803)4.54660351
24neurotransmitter secretion (GO:0007269)4.39260834
25regulation of dendritic spine morphogenesis (GO:0061001)4.29507180
26dendritic spine morphogenesis (GO:0060997)4.23937320
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.14974310
28neuronal action potential propagation (GO:0019227)4.12798442
29synaptic transmission, glutamatergic (GO:0035249)4.08774175
30glutamate receptor signaling pathway (GO:0007215)4.06412120
31long-term memory (GO:0007616)3.99928729
32activation of protein kinase A activity (GO:0034199)3.99743366
33G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.99677447
34neurotransmitter-gated ion channel clustering (GO:0072578)3.99286840
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.97258544
36positive regulation of synapse maturation (GO:0090129)3.94874840
37proline transport (GO:0015824)3.93088632
38cellular potassium ion homeostasis (GO:0030007)3.91949739
39neuron-neuron synaptic transmission (GO:0007270)3.91822320
40neuron cell-cell adhesion (GO:0007158)3.89368114
41regulation of synaptic plasticity (GO:0048167)3.88897171
42positive regulation of membrane potential (GO:0045838)3.88076388
43regulation of beta-amyloid formation (GO:1902003)3.83142804
44sodium ion export (GO:0071436)3.82865717
45nuclear pore organization (GO:0006999)3.82233182
46neuromuscular process controlling balance (GO:0050885)3.81691170
47positive regulation of gamma-delta T cell activation (GO:0046645)3.77379425
48positive regulation of cellular amide metabolic process (GO:0034250)3.73928405
49cytoskeletal anchoring at plasma membrane (GO:0007016)3.73212737
50regulation of postsynaptic membrane potential (GO:0060078)3.72562597
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.68759802
52regulation of amyloid precursor protein catabolic process (GO:1902991)3.59783777
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59461773
54long-term synaptic potentiation (GO:0060291)3.57439574
55detection of molecule of bacterial origin (GO:0032490)3.55814383
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.53417203
57vesicle transport along microtubule (GO:0047496)3.51934374
58gamma-aminobutyric acid transport (GO:0015812)3.48489930
59positive regulation of neurotransmitter secretion (GO:0001956)3.46606772
60dendritic spine organization (GO:0097061)3.45816941
61cerebellar granule cell differentiation (GO:0021707)3.45714901
62regulation of dendritic spine development (GO:0060998)3.44191419
63prepulse inhibition (GO:0060134)3.42362987
64behavioral fear response (GO:0001662)3.40600491
65behavioral defense response (GO:0002209)3.40600491
66neurotransmitter transport (GO:0006836)3.32896466
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31902987
68neuron recognition (GO:0008038)3.31690785
69synaptic vesicle endocytosis (GO:0048488)3.31159668
70pore complex assembly (GO:0046931)3.30722772
71regulation of nucleobase-containing compound transport (GO:0032239)3.30558996
72L-amino acid import (GO:0043092)3.30508021
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.29983319
74positive regulation of neurotransmitter transport (GO:0051590)3.29855359
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27501505
76regulation of neurotransmitter secretion (GO:0046928)3.27166784
77innervation (GO:0060384)3.25276706
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24539037
79response to histamine (GO:0034776)3.24379920
80auditory behavior (GO:0031223)3.23349850
81positive regulation of dendritic spine development (GO:0060999)3.21944780
82regulation of vesicle fusion (GO:0031338)3.21228112
83* peptidyl-threonine phosphorylation (GO:0018107)3.20940785
84regulation of histone H3-K27 methylation (GO:0061085)3.20895298
85dendrite morphogenesis (GO:0048813)3.20671650
86cellular extravasation (GO:0045123)3.19975459
87axonal fasciculation (GO:0007413)3.19183252
88cell communication by electrical coupling (GO:0010644)3.18951798
89regulation of ARF protein signal transduction (GO:0032012)3.18806979
90iron ion import (GO:0097286)3.15676655
91regulation of clathrin-mediated endocytosis (GO:2000369)3.15185959
92fear response (GO:0042596)3.14232802
93establishment of nucleus localization (GO:0040023)3.13279684
94regulation of neurotransmitter levels (GO:0001505)3.13194913
95transmission of nerve impulse (GO:0019226)3.09858037
96gamma-aminobutyric acid signaling pathway (GO:0007214)3.06000012
97regulation of RNA export from nucleus (GO:0046831)3.05747670
98regulation of cellular amide metabolic process (GO:0034248)3.05645356
99regulation of neurotransmitter transport (GO:0051588)3.03693669
100organelle transport along microtubule (GO:0072384)3.03555228
101positive regulation of fibroblast migration (GO:0010763)3.03257677
102gas transport (GO:0015669)3.02893832
103learning (GO:0007612)3.02485192
104* peptidyl-threonine modification (GO:0018210)3.02296688
105protein localization to endosome (GO:0036010)3.01957157
106response to auditory stimulus (GO:0010996)3.01852524
107membrane depolarization (GO:0051899)3.00746731
108cerebellar Purkinje cell differentiation (GO:0021702)3.00601623
109positive regulation of synaptic transmission (GO:0050806)3.00511073
110neuromuscular process (GO:0050905)2.99901852
111long term synaptic depression (GO:0060292)2.97536830
112negative regulation of cell killing (GO:0031342)2.96889774
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96889774
114hypotonic response (GO:0006971)2.96831356
115social behavior (GO:0035176)2.96739568
116intraspecies interaction between organisms (GO:0051703)2.96739568
117regulation of synaptic transmission (GO:0050804)2.96259246
118dopamine receptor signaling pathway (GO:0007212)2.96178483
119regulation of female receptivity (GO:0045924)2.94056899
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93580614
121positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.92051583
122chemosensory behavior (GO:0007635)2.90033721
123clathrin coat assembly (GO:0048268)2.88521637
124glycine transport (GO:0015816)2.86805842
125amino acid import (GO:0043090)2.86709264
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85804878
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.85804878
128modulation by symbiont of host immune response (GO:0052553)2.85804878
129positive regulation by symbiont of host defense response (GO:0052509)2.85804878
130modulation by symbiont of host defense response (GO:0052031)2.85804878
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85804878
132neuronal ion channel clustering (GO:0045161)2.85622861
133histone H3-K9 demethylation (GO:0033169)2.85483114
134membrane depolarization during action potential (GO:0086010)2.83242687
135import into cell (GO:0098657)2.79822486
136oxygen transport (GO:0015671)2.77098684
137positive regulation of Rap GTPase activity (GO:0032854)2.76994955
138cortical actin cytoskeleton organization (GO:0030866)2.75155075
139positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.74403487
140negative regulation of dendrite morphogenesis (GO:0050774)2.73922035
141definitive hemopoiesis (GO:0060216)2.72198137
142potassium ion homeostasis (GO:0055075)2.71620473
143positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70768476
144regulation of NFAT protein import into nucleus (GO:0051532)2.69423804
145macrophage activation involved in immune response (GO:0002281)2.68213551
146vesicle coating (GO:0006901)2.66928289
147phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.66730184
148nerve growth factor signaling pathway (GO:0038180)2.61274984
149protein export from nucleus (GO:0006611)2.58301282
150positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57314954
151positive regulation of receptor recycling (GO:0001921)2.56670813
152positive regulation of protein dephosphorylation (GO:0035307)2.56471129
153protoporphyrinogen IX metabolic process (GO:0046501)2.55744599
154detection of external biotic stimulus (GO:0098581)2.53977123
155regulation of regulated secretory pathway (GO:1903305)2.51338685
156cellular response to thyroid hormone stimulus (GO:0097067)2.49345210
157COPI coating of Golgi vesicle (GO:0048205)2.49206962
158Golgi transport vesicle coating (GO:0048200)2.49206962
159regulation of leukocyte degranulation (GO:0043300)2.48486548
160embryonic process involved in female pregnancy (GO:0060136)2.48333141
161regulation of gamma-delta T cell differentiation (GO:0045586)2.45903074
162corticosteroid receptor signaling pathway (GO:0031958)2.44974388
163cell-substrate adherens junction assembly (GO:0007045)2.43925170
164focal adhesion assembly (GO:0048041)2.43925170
165potassium ion import (GO:0010107)2.43019290
166regulation of ARF GTPase activity (GO:0032312)2.41345871
167negative regulation of potassium ion transmembrane transport (GO:1901380)2.40745073
168myeloid cell development (GO:0061515)2.37909253
169regulation of Rap GTPase activity (GO:0032317)2.37808264
170megakaryocyte development (GO:0035855)2.37122508
171cellular response to catecholamine stimulus (GO:0071870)2.36101452
172cellular response to monoamine stimulus (GO:0071868)2.36101452
173cortical cytoskeleton organization (GO:0030865)2.35510064
174regulation of B cell receptor signaling pathway (GO:0050855)2.35296636
175regulation of Rac protein signal transduction (GO:0035020)2.31912639
176regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.31386971
177regulation of gamma-delta T cell activation (GO:0046643)2.31033269
178erythrocyte development (GO:0048821)2.30345386
179positive regulation of regulated secretory pathway (GO:1903307)2.29748801
180negative regulation of protein localization to plasma membrane (GO:1903077)2.29387652
181phosphatidylinositol phosphorylation (GO:0046854)2.26122376
182histone H3-K36 demethylation (GO:0070544)2.25474873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23993141
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.56748316
3* EGR1_19374776_ChIP-ChIP_THP-1_Human3.47267227
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06702287
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01469049
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01176675
7GBX2_23144817_ChIP-Seq_PC3_Human2.92834045
8REST_21632747_ChIP-Seq_MESCs_Mouse2.86633092
9GATA1_19941826_ChIP-Seq_K562_Human2.80318173
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.74785048
11DROSHA_22980978_ChIP-Seq_HELA_Human2.72745255
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69953971
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69942142
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69942142
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54864222
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54734536
17SPI1_23127762_ChIP-Seq_K562_Human2.54421593
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52026457
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51292921
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47204017
21GATA1_22025678_ChIP-Seq_K562_Human2.47092493
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44571214
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.40292105
24E2F7_22180533_ChIP-Seq_HELA_Human2.37415643
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35081304
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29437303
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.25771653
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22504870
29TCF7_22412390_ChIP-Seq_EML_Mouse2.20372742
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.19060499
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15692099
32GATA2_19941826_ChIP-Seq_K562_Human2.15223654
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13092359
34RNF2_27304074_Chip-Seq_ESCs_Mouse2.13090716
35SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09769822
36AR_21572438_ChIP-Seq_LNCaP_Human2.05729123
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05036476
38MYC_22102868_ChIP-Seq_BL_Human2.04216843
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03117455
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02583004
41EZH2_27294783_Chip-Seq_ESCs_Mouse2.02304049
42* NCOR1_26117541_ChIP-Seq_K562_Human1.98636762
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98279456
44SCL_19346495_ChIP-Seq_HPC-7_Human1.93248864
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.90684344
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83575372
47* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81958101
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80815749
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.76773439
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76047309
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75916683
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.75443582
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72444722
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71504761
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71107281
56* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71056949
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.69837485
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67816327
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66302833
60* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64695677
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58490167
62* CLOCK_20551151_ChIP-Seq_293T_Human1.57173977
63* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55461662
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51460389
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51341123
66ZNF274_21170338_ChIP-Seq_K562_Hela1.50967538
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50446557
68* KDM2B_26808549_Chip-Seq_K562_Human1.50228458
69SMAD4_21799915_ChIP-Seq_A2780_Human1.49451526
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.47073205
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45197856
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44048101
73RUNX_20019798_ChIP-Seq_JUKART_Human1.42691314
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.41823825
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41390851
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40603987
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40419476
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40076470
79* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39791996
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.39530441
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.39475785
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39444401
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39384995
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37947725
85VDR_21846776_ChIP-Seq_THP-1_Human1.36614411
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36587065
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36464199
88MAF_26560356_Chip-Seq_TH1_Human1.36449868
89AR_19668381_ChIP-Seq_PC3_Human1.34952087
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34512321
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.33482859
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.33272660
93* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.32010194
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30302743
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29446981
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27321513
97* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25820389
98* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25664926
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25476729
100TP53_16413492_ChIP-PET_HCT116_Human1.23945156
101LXR_22292898_ChIP-Seq_THP-1_Human1.21956674
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21901200
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.21628877
104* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21263016
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20530670
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19873942
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.19698358
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19680482
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17383361
110VDR_24763502_ChIP-Seq_THP-1_Human1.16854538
111STAT3_23295773_ChIP-Seq_U87_Human1.15184757
112AR_25329375_ChIP-Seq_VCAP_Human1.14626322
113ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13707994
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12730342
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11989834
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11748812
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11424249
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.11141370
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.08275990
120TBX20_22328084_ChIP-Seq_HEART_Mouse1.08275990
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07282504
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06726272
123FOXA2_19822575_ChIP-Seq_HepG2_Human1.06676815
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06282749
125TAF15_26573619_Chip-Seq_HEK293_Human1.06041039
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05956195
127RACK7_27058665_Chip-Seq_MCF-7_Human1.05810727
128KDM2B_26808549_Chip-Seq_DND41_Human1.05750606
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04411021
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03042569
131NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01773969
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01296683
133KDM2B_26808549_Chip-Seq_JURKAT_Human1.01260586
134* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00058632
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00003357
136* RXR_22108803_ChIP-Seq_LS180_Human0.99681920
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99203866
138P300_19829295_ChIP-Seq_ESCs_Human0.98908285
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98097430
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.97683336
141ZNF263_19887448_ChIP-Seq_K562_Human0.97617965
142TCF4_23295773_ChIP-Seq_U87_Human0.96710612
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.96075728
144* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95590021
145PU_27001747_Chip-Seq_BMDM_Mouse0.95179693
146TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94308865
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94140625
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94061001
149TP63_17297297_ChIP-ChIP_HaCaT_Human0.93891292
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93867796
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93521966
152TET1_21490601_ChIP-Seq_MESCs_Mouse0.92882199
153ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92810345
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92232673
155AHR_22903824_ChIP-Seq_MCF-7_Human0.92183059
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.91719881
157GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91643489
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91410507
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.90817397
160FOXO3_23340844_ChIP-Seq_DLD1_Human0.90485507
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89768091
162* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89453402
163ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89402561
164CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89331067
165CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89188522
166KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88641859
167PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88300965
168ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87814855
169UTX_26944678_Chip-Seq_JUKART_Human0.87639244
170RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87390554
171* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86603056
172AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85950949
173CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85895514
174SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85507045
175* PRDM14_20953172_ChIP-Seq_ESCs_Human0.84451327
176* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83940584
177MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83900044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.78063418
2MP0003880_abnormal_central_pattern4.51266059
3MP0003635_abnormal_synaptic_transmissio4.50757205
4MP0004270_analgesia3.89948408
5MP0005451_abnormal_body_composition3.67413441
6* MP0002063_abnormal_learning/memory/cond3.59606990
7MP0009745_abnormal_behavioral_response3.48820311
8MP0002822_catalepsy3.46636727
9MP0003705_abnormal_hypodermis_morpholog3.43051123
10MP0002877_abnormal_melanocyte_morpholog3.11693018
11MP0002064_seizures3.10843521
12MP0005409_darkened_coat_color3.06528194
13MP0001968_abnormal_touch/_nociception2.84055821
14MP0003300_gastrointestinal_ulcer2.77365104
15MP0002572_abnormal_emotion/affect_behav2.77151824
16MP0003690_abnormal_glial_cell2.77058811
17MP0008260_abnormal_autophagy2.72696204
18MP0003656_abnormal_erythrocyte_physiolo2.70980192
19MP0009046_muscle_twitch2.66214952
20MP0009780_abnormal_chondrocyte_physiolo2.39440691
21MP0001486_abnormal_startle_reflex2.38899554
22MP0002734_abnormal_mechanical_nocicepti2.37805250
23MP0002272_abnormal_nervous_system2.32898097
24MP0005423_abnormal_somatic_nervous2.27315540
25MP0003303_peritoneal_inflammation2.22277116
26MP0003566_abnormal_cell_adhesion2.11796966
27MP0002909_abnormal_adrenal_gland2.07390212
28MP0010234_abnormal_vibrissa_follicle2.03154118
29MP0004811_abnormal_neuron_physiology2.02827668
30MP0003329_amyloid_beta_deposits2.02705448
31MP0002736_abnormal_nociception_after2.01760873
32MP0001501_abnormal_sleep_pattern2.01620065
33MP0004858_abnormal_nervous_system2.00319465
34MP0001440_abnormal_grooming_behavior1.97037083
35MP0002735_abnormal_chemical_nociception1.91328161
36MP0005464_abnormal_platelet_physiology1.88501126
37MP0000920_abnormal_myelination1.88459860
38MP0003191_abnormal_cellular_cholesterol1.88126816
39MP0002733_abnormal_thermal_nociception1.86650094
40MP0008569_lethality_at_weaning1.85808312
41MP0003091_abnormal_cell_migration1.84223227
42MP0004924_abnormal_behavior1.75471937
43MP0005386_behavior/neurological_phenoty1.75471937
44MP0001970_abnormal_pain_threshold1.74201670
45MP0010352_gastrointestinal_tract_polyps1.71954618
46MP0002067_abnormal_sensory_capabilities1.67984036
47MP0005058_abnormal_lysosome_morphology1.66032441
48MP0002184_abnormal_innervation1.64205552
49MP0002557_abnormal_social/conspecific_i1.64102439
50MP0000778_abnormal_nervous_system1.61168550
51MP0001958_emphysema1.60189026
52MP0003879_abnormal_hair_cell1.56819241
53MP0005076_abnormal_cell_differentiation1.55387758
54MP0002396_abnormal_hematopoietic_system1.55342974
55MP0002009_preneoplasia1.55082592
56MP0001915_intracranial_hemorrhage1.54986064
57MP0000955_abnormal_spinal_cord1.54746160
58MP0004808_abnormal_hematopoietic_stem1.52747633
59MP0003787_abnormal_imprinting1.49615551
60MP0004885_abnormal_endolymph1.48605263
61MP0008438_abnormal_cutaneous_collagen1.48276203
62MP0003436_decreased_susceptibility_to1.46223534
63MP0003828_pulmonary_edema1.46198674
64MP0000015_abnormal_ear_pigmentation1.43101992
65MP0000569_abnormal_digit_pigmentation1.40506779
66MP0003283_abnormal_digestive_organ1.38311097
67MP0002066_abnormal_motor_capabilities/c1.35422885
68MP0003633_abnormal_nervous_system1.35105452
69MP0004883_abnormal_blood_vessel1.33609891
70MP0002882_abnormal_neuron_morphology1.31634986
71MP0008961_abnormal_basal_metabolism1.30179394
72MP0008057_abnormal_DNA_replication1.29160150
73MP0005646_abnormal_pituitary_gland1.25340165
74MP0003724_increased_susceptibility_to1.24965018
75MP0004947_skin_inflammation1.20626590
76MP0001984_abnormal_olfaction1.19899195
77MP0004147_increased_porphyrin_level1.19251617
78MP0000678_abnormal_parathyroid_gland1.18417244
79MP0005621_abnormal_cell_physiology1.15292714
80* MP0002152_abnormal_brain_morphology1.14638006
81MP0001851_eye_inflammation1.12948712
82MP0003631_nervous_system_phenotype1.10879789
83MP0002419_abnormal_innate_immunity1.10674116
84MP0003075_altered_response_to1.09926720
85MP0003045_fibrosis1.08150843
86MP0003123_paternal_imprinting1.06953089
87MP0001529_abnormal_vocalization1.06786507
88MP0003453_abnormal_keratinocyte_physiol1.06718755
89MP0000013_abnormal_adipose_tissue1.04770941
90MP0000858_altered_metastatic_potential1.04360216
91MP0005187_abnormal_penis_morphology1.03155441
92MP0000751_myopathy1.02655119
93MP0008874_decreased_physiological_sensi1.01811818
94MP0008872_abnormal_physiological_respon0.99829720
95MP0005397_hematopoietic_system_phenotyp0.99477423
96MP0001545_abnormal_hematopoietic_system0.99477423
97MP0004185_abnormal_adipocyte_glucose0.98527873
98MP0003122_maternal_imprinting0.95871317
99MP0001502_abnormal_circadian_rhythm0.95406456
100MP0000604_amyloidosis0.94205166
101MP0004233_abnormal_muscle_weight0.92939795
102MP0001177_atelectasis0.92829858
103* MP0000703_abnormal_thymus_morphology0.91912484
104MP0002069_abnormal_eating/drinking_beha0.91447096
105MP0004510_myositis0.91202756
106MP0009278_abnormal_bone_marrow0.89866737
107MP0005623_abnormal_meninges_morphology0.87991833
108MP0005164_abnormal_response_to0.86999547
109MP0003763_abnormal_thymus_physiology0.86605337
110MP0005388_respiratory_system_phenotype0.85107195
111MP0002133_abnormal_respiratory_system0.85107195
112MP0010630_abnormal_cardiac_muscle0.84570748
113* MP0002398_abnormal_bone_marrow0.83864425
114MP0002132_abnormal_respiratory_system0.83171581
115MP0004145_abnormal_muscle_electrophysio0.80762665
116MP0004085_abnormal_heartbeat0.80725361
117MP0001188_hyperpigmentation0.78665532
118MP0002998_abnormal_bone_remodeling0.77892896
119MP0006276_abnormal_autonomic_nervous0.76243600
120MP0005384_cellular_phenotype0.75511193
121* MP0002086_abnormal_extraembryonic_tissu0.75352709
122MP0004215_abnormal_myocardial_fiber0.75063294
123MP0005174_abnormal_tail_pigmentation0.75063048
124MP0004484_altered_response_of0.74314459
125MP0005645_abnormal_hypothalamus_physiol0.74273071
126MP0005167_abnormal_blood-brain_barrier0.74057443
127MP0003632_abnormal_nervous_system0.73451601
128MP0010307_abnormal_tumor_latency0.71118984
129MP0001905_abnormal_dopamine_level0.69931075
130MP0006082_CNS_inflammation0.68579213
131MP0005535_abnormal_body_temperature0.68486067
132MP0002229_neurodegeneration0.67795913
133MP0003221_abnormal_cardiomyocyte_apopto0.66806076
134MP0002234_abnormal_pharynx_morphology0.66730602
135MP0001730_embryonic_growth_arrest0.66721439
136* MP0003861_abnormal_nervous_system0.66619572
137MP0000428_abnormal_craniofacial_morphol0.66593349
138MP0002971_abnormal_brown_adipose0.66233230
139MP0003183_abnormal_peptide_metabolism0.65591477
140MP0002090_abnormal_vision0.65086491
141MP0004142_abnormal_muscle_tone0.64875440
142MP0000631_abnormal_neuroendocrine_gland0.64863507
143MP0005166_decreased_susceptibility_to0.64773498
144MP0004264_abnormal_extraembryonic_tissu0.64721676
145MP0005023_abnormal_wound_healing0.64073418
146MP0001849_ear_inflammation0.63959390
147MP0003634_abnormal_glial_cell0.63847113
148* MP0002722_abnormal_immune_system0.63369556
149MP0003959_abnormal_lean_body0.62879371
150MP0004130_abnormal_muscle_cell0.62524312
151MP0004134_abnormal_chest_morphology0.60454342
152MP0000747_muscle_weakness0.60086190
153MP0003448_altered_tumor_morphology0.59319618
154MP0002089_abnormal_postnatal_growth/wei0.58751456
155MP0001835_abnormal_antigen_presentation0.58681907
156MP0005394_taste/olfaction_phenotype0.58665052
157MP0005499_abnormal_olfactory_system0.58665052
158MP0005025_abnormal_response_to0.58432266
159MP0003172_abnormal_lysosome_physiology0.58425225
160MP0010769_abnormal_survival0.56881730
161MP0001299_abnormal_eye_distance/0.56852192
162MP0001348_abnormal_lacrimal_gland0.56059754
163MP0002837_dystrophic_cardiac_calcinosis0.55566101
164MP0001664_abnormal_digestion0.55091836
165MP0001943_abnormal_respiration0.54361441
166MP0003121_genomic_imprinting0.53988300
167MP0010768_mortality/aging0.52972836
168* MP0003956_abnormal_body_size0.52942609
169MP0010770_preweaning_lethality0.52504459
170MP0002082_postnatal_lethality0.52504459
171MP0008770_decreased_survivor_rate0.51836590

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.07943579
2Myokymia (HP:0002411)6.76300460
3Focal seizures (HP:0007359)5.49070639
4Visual hallucinations (HP:0002367)5.41199418
5Epileptic encephalopathy (HP:0200134)4.22537503
6Papilledema (HP:0001085)3.95504951
7Absence seizures (HP:0002121)3.85485837
8Impaired vibration sensation in the lower limbs (HP:0002166)3.78575312
9Atonic seizures (HP:0010819)3.76424326
10Poor eye contact (HP:0000817)3.71925168
11Action tremor (HP:0002345)3.64978265
12Progressive cerebellar ataxia (HP:0002073)3.54967471
13Depression (HP:0000716)3.48414152
14Dialeptic seizures (HP:0011146)3.46691068
15Abnormality of the lower motor neuron (HP:0002366)3.44155629
16Generalized tonic-clonic seizures (HP:0002069)3.43697200
17Abnormal social behavior (HP:0012433)3.37357685
18Impaired social interactions (HP:0000735)3.37357685
19Polycythemia (HP:0001901)3.35251669
20Febrile seizures (HP:0002373)3.33115445
21Urinary bladder sphincter dysfunction (HP:0002839)3.27351485
22Ankle clonus (HP:0011448)3.23917160
23Broad-based gait (HP:0002136)3.21143494
24Urinary urgency (HP:0000012)3.19784219
25Supranuclear gaze palsy (HP:0000605)3.18012955
26Impaired smooth pursuit (HP:0007772)3.08041642
27Truncal ataxia (HP:0002078)3.04855806
28Dysdiadochokinesis (HP:0002075)2.99530052
29Postural instability (HP:0002172)2.96613390
30Abnormal gallbladder physiology (HP:0012438)2.95198275
31Cholecystitis (HP:0001082)2.95198275
32Eczematoid dermatitis (HP:0000976)2.94705976
33Annular pancreas (HP:0001734)2.92367820
34Gaze-evoked nystagmus (HP:0000640)2.92271894
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.86688688
36Dysmetric saccades (HP:0000641)2.86098351
37Dysmetria (HP:0001310)2.84185717
38Termporal pattern (HP:0011008)2.83162474
39Insidious onset (HP:0003587)2.83162474
40Amblyopia (HP:0000646)2.81686899
41Mutism (HP:0002300)2.75110216
42Anxiety (HP:0000739)2.73950406
43Drooling (HP:0002307)2.65669168
44Excessive salivation (HP:0003781)2.65669168
45Resting tremor (HP:0002322)2.63345807
46Genetic anticipation (HP:0003743)2.60880943
47Abnormality of ocular smooth pursuit (HP:0000617)2.60568894
48Torticollis (HP:0000473)2.60236062
49* Bowel incontinence (HP:0002607)2.58171768
50Hyperventilation (HP:0002883)2.56333435
51* Pointed chin (HP:0000307)2.54669175
52Bradykinesia (HP:0002067)2.52889125
53Cerebral inclusion bodies (HP:0100314)2.52490361
54* Ankyloglossia (HP:0010296)2.51961484
55Hyperthyroidism (HP:0000836)2.50762948
56Megalencephaly (HP:0001355)2.46872579
57Amyotrophic lateral sclerosis (HP:0007354)2.46299796
58Focal dystonia (HP:0004373)2.45428763
59Scanning speech (HP:0002168)2.45326126
60Peripheral hypomyelination (HP:0007182)2.44764946
61Insomnia (HP:0100785)2.43794771
62* Stereotypic behavior (HP:0000733)2.42883329
63Abnormal eating behavior (HP:0100738)2.41752048
64Spastic gait (HP:0002064)2.41145235
65Decreased motor nerve conduction velocity (HP:0003431)2.39706387
66Intention tremor (HP:0002080)2.38799727
67Slow saccadic eye movements (HP:0000514)2.37953124
68* Abnormal large intestine physiology (HP:0012700)2.37662504
69Impaired vibratory sensation (HP:0002495)2.36810579
70Epileptiform EEG discharges (HP:0011182)2.35989094
71Abnormality of binocular vision (HP:0011514)2.34625132
72Diplopia (HP:0000651)2.34625132
73Reticulocytosis (HP:0001923)2.32830467
74Inappropriate behavior (HP:0000719)2.26806820
75Papillary thyroid carcinoma (HP:0002895)2.26296281
76EEG with generalized epileptiform discharges (HP:0011198)2.25811651
77Hemiplegia (HP:0002301)2.24913872
78Relative macrocephaly (HP:0004482)2.23588651
79Progressive inability to walk (HP:0002505)2.20041421
80Hypsarrhythmia (HP:0002521)2.17798202
81Ventricular fibrillation (HP:0001663)2.16409858
82Craniofacial dystonia (HP:0012179)2.15332903
83Apathy (HP:0000741)2.14445708
84Subacute progressive viral hepatitis (HP:0006572)2.14351529
85* Truncus arteriosus (HP:0001660)2.12947440
86Intellectual disability, profound (HP:0002187)2.12780344
87Deep palmar crease (HP:0006191)2.12458545
88Lower limb asymmetry (HP:0100559)2.11241903
89Lower limb amyotrophy (HP:0007210)2.09459585
90Spontaneous hematomas (HP:0007420)2.09286071
91Disproportionate tall stature (HP:0001519)2.09028435
92Status epilepticus (HP:0002133)2.06381342
93Lower limb muscle weakness (HP:0007340)2.05857521
94Abnormality of macrophages (HP:0004311)2.03605989
95Hemiparesis (HP:0001269)2.02925644
96Arterial tortuosity (HP:0005116)2.00704149
97Recurrent abscess formation (HP:0002722)2.00578998
98Gingivitis (HP:0000230)2.00553642
99* Abnormality of oral frenula (HP:0000190)1.99910595
100Recurrent bacterial skin infections (HP:0005406)1.98829367
101Absent speech (HP:0001344)1.97474279
102Clonus (HP:0002169)1.96894600
103Obstructive sleep apnea (HP:0002870)1.96069196
104Macroorchidism (HP:0000053)1.95883110
105Acute myeloid leukemia (HP:0004808)1.95446051
106Shoulder girdle muscle weakness (HP:0003547)1.94904238
107Cellulitis (HP:0100658)1.94904080
108Metaphyseal cupping (HP:0003021)1.94046105
109Diminished motivation (HP:0000745)1.93961158
110Achilles tendon contracture (HP:0001771)1.93686105
111Rapidly progressive (HP:0003678)1.92831149
112Abnormality of the corticospinal tract (HP:0002492)1.92768177
113Cerebral aneurysm (HP:0004944)1.91466498
114Hammertoe (HP:0001765)1.89101382
115Peritonitis (HP:0002586)1.89025823
116Bundle branch block (HP:0011710)1.88754693
117Neurofibrillary tangles (HP:0002185)1.87871150
118Gait ataxia (HP:0002066)1.87511381
119Vascular tortuosity (HP:0004948)1.86783682
120Heterotopia (HP:0002282)1.86709831
121Abnormality of the common coagulation pathway (HP:0010990)1.85293641
122Poikilocytosis (HP:0004447)1.85282946
12311 pairs of ribs (HP:0000878)1.85091400
124Incomplete penetrance (HP:0003829)1.85021920
125Recurrent gram-negative bacterial infections (HP:0005420)1.82378363
126Segmental peripheral demyelination/remyelination (HP:0003481)1.81400207
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80609810
128Abnormality of the fingertips (HP:0001211)1.79135455
129Foot dorsiflexor weakness (HP:0009027)1.79126727
130Onion bulb formation (HP:0003383)1.78503291
131Abnormality of saccadic eye movements (HP:0000570)1.78296831
132Prolonged bleeding time (HP:0003010)1.77693754
133Neoplasm of the peripheral nervous system (HP:0100007)1.76889834
134Inability to walk (HP:0002540)1.75356950
135Generalized myoclonic seizures (HP:0002123)1.74787311
136Hypoventilation (HP:0002791)1.74678831
137Neuronal loss in central nervous system (HP:0002529)1.74651292
138Acanthocytosis (HP:0001927)1.74193323
139Fetal akinesia sequence (HP:0001989)1.72148705
140Abnormality of the astrocytes (HP:0100707)1.72043677
141Astrocytoma (HP:0009592)1.72043677
142* Dilatation of the ascending aorta (HP:0005111)1.71698579
143Chronic obstructive pulmonary disease (HP:0006510)1.71542260
144Obstructive lung disease (HP:0006536)1.71542260
145Orthostatic hypotension (HP:0001278)1.71256305
146Abnormality of the periventricular white matter (HP:0002518)1.71140683
147Dislocated radial head (HP:0003083)1.70335777
148Gingival bleeding (HP:0000225)1.69757298
149Agitation (HP:0000713)1.69622547
150Distal sensory impairment (HP:0002936)1.69372782
151Gastrointestinal infarctions (HP:0005244)1.68907180
152Increased connective tissue (HP:0009025)1.68254594
153Aqueductal stenosis (HP:0002410)1.68055201
154Rigidity (HP:0002063)1.68014040
155Protrusio acetabuli (HP:0003179)1.67706355
156Vertebral arch anomaly (HP:0008438)1.66575247
157Difficulty running (HP:0009046)1.65845832
158Atelectasis (HP:0100750)1.64529283
159Hypertensive crisis (HP:0100735)1.64097487
160Abnormality of the tricuspid valve (HP:0001702)1.63190674
161Patellar dislocation (HP:0002999)1.62593390
162Missing ribs (HP:0000921)1.60282821
163Tetraplegia (HP:0002445)1.60016502
164Hyperacusis (HP:0010780)1.59505588
165Overgrowth (HP:0001548)1.58056903
166Mitral regurgitation (HP:0001653)1.54101310
167Asymmetry of the thorax (HP:0001555)1.53706090
168Deep philtrum (HP:0002002)1.53349626
169Abnormality of the foot musculature (HP:0001436)1.52530999
170Distal upper limb amyotrophy (HP:0007149)1.52214412
171Upper limb amyotrophy (HP:0009129)1.52214412
172Viral hepatitis (HP:0006562)1.52092166
173Flat cornea (HP:0007720)1.50625936
174Abnormality of the radial head (HP:0003995)1.49551354
175Increased variability in muscle fiber diameter (HP:0003557)1.49458053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.23399715
2MAP3K94.60363908
3* NTRK33.50806683
4MARK12.89666511
5MINK12.88456006
6DAPK22.88445580
7MAP3K42.74072048
8PAK62.47822678
9CDK122.42565161
10RIPK42.40852491
11PRKD32.32104000
12CAMKK12.24848909
13DAPK11.99965924
14ICK1.97132548
15FGFR31.93359448
16NTRK11.88988775
17MAP2K41.84660136
18MAP2K71.82552476
19WNK11.82433153
20NTRK21.77491867
21SCYL21.76039502
22MAP2K31.68013774
23MAP3K131.67842580
24FGFR41.61567543
25MAP3K121.61322207
26CDK51.59699674
27* KSR21.56781369
28SIK21.45407683
29ARAF1.44665106
30NEK11.44446548
31PLK21.39681773
32BLK1.38999394
33YES11.36925671
34CDK191.35968440
35TYRO31.34510829
36TAOK11.33475934
37EPHB11.30416850
38FES1.30181816
39STK381.29251262
40* KSR11.28046506
41TYK21.24027288
42ZAP701.22807053
43LATS21.22613027
44ERN11.21780517
45CAMKK21.18327493
46CLK11.17024785
47ALK1.15923636
48JAK11.13448679
49CSK1.11790332
50* JAK21.10235235
51PRKCG1.07961489
52PNCK1.06262066
53NEK61.04518767
54CDK141.00287003
55CDK180.99595800
56GRK50.99103114
57UHMK10.98996696
58CDK150.98385876
59PRKCH0.97869674
60EIF2AK10.96948777
61STK110.94760664
62RIPK10.93717507
63JAK30.91836040
64TRIB30.90784029
65PDK10.89265296
66CAMK10.88871715
67LMTK20.88377500
68PKN20.87292747
69PDGFRB0.87147686
70CDK11A0.86496186
71MAPK120.85824868
72TNIK0.84055019
73PTK2B0.83994861
74PAK30.83233409
75MAPK130.82916280
76TTN0.82041143
77PRPF4B0.81801686
78HCK0.80016521
79TRPM70.79998328
80* MAP3K10.78278847
81SMG10.77040406
82CAMK2A0.76589906
83PTK60.76328606
84PDPK10.74372580
85SGK30.70360266
86* RET0.70238904
87PHKG20.70037177
88PHKG10.70037177
89BRD40.69836685
90BRSK10.66734392
91PIK3CG0.65122668
92MAP3K70.64845546
93CSNK1G20.64534273
94MAP3K140.64270223
95MTOR0.63966746
96IRAK40.63036646
97* SGK10.62536565
98DMPK0.61918887
99BTK0.61737843
100SGK2230.61151610
101SGK4940.61151610
102SYK0.60840183
103MARK20.59803281
104IRAK20.59324948
105SGK20.58557298
106CAMK2B0.58037937
107NEK90.57325235
108CAMK1D0.56992261
109MAP3K100.54892597
110CDK60.54884765
111DYRK1A0.54156143
112RPS6KA30.54093266
113* MAP3K20.53740756
114CCNB10.53307099
115MAP3K30.52530563
116BMPR20.52287758
117FYN0.51775261
118LRRK20.50721041
119RPS6KB10.49080177
120PDGFRA0.47986743
121FER0.47352802
122MAPK100.46691026
123DAPK30.46069008
124PRKCZ0.45249531
125MAPK110.44983777
126CAMK1G0.42455193
127AKT30.42327514
128EEF2K0.41349885
129CDC42BPA0.37412962
130FGR0.35750154
131FGFR20.35736654
132CAMK40.35695891
133PRKCB0.34399874
134CSNK1E0.33535396
135MOS0.33232432
136MAP3K60.31256949
137RPS6KA20.29761758
138TNK20.28278785
139BMX0.27873458
140GRK60.27764115
141MAPK80.26470435
142FGFR10.25673250
143SRC0.25157416
144CASK0.24713883
145DDR20.24301741

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.13664361
2* Long-term potentiation_Homo sapiens_hsa047202.94478570
3Synaptic vesicle cycle_Homo sapiens_hsa047212.93634304
4Olfactory transduction_Homo sapiens_hsa047402.82475843
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64944036
6* Circadian entrainment_Homo sapiens_hsa047132.59694278
7Amphetamine addiction_Homo sapiens_hsa050312.58419165
8GABAergic synapse_Homo sapiens_hsa047272.42460921
9* Glutamatergic synapse_Homo sapiens_hsa047242.38428960
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37783334
11Morphine addiction_Homo sapiens_hsa050322.35632263
12* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33495603
13Dopaminergic synapse_Homo sapiens_hsa047282.23537019
14Salivary secretion_Homo sapiens_hsa049702.16690484
15Gastric acid secretion_Homo sapiens_hsa049712.01418560
16* Chronic myeloid leukemia_Homo sapiens_hsa052201.95688915
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94227298
18Insulin secretion_Homo sapiens_hsa049111.91502176
19* Cholinergic synapse_Homo sapiens_hsa047251.88154306
20Renin secretion_Homo sapiens_hsa049241.83752052
21* Oxytocin signaling pathway_Homo sapiens_hsa049211.78479282
22* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72135888
23Cocaine addiction_Homo sapiens_hsa050301.62118298
24* Long-term depression_Homo sapiens_hsa047301.58539447
25* GnRH signaling pathway_Homo sapiens_hsa049121.58022240
26* Pancreatic cancer_Homo sapiens_hsa052121.53324610
27Calcium signaling pathway_Homo sapiens_hsa040201.52951201
28* Acute myeloid leukemia_Homo sapiens_hsa052211.50895622
29* B cell receptor signaling pathway_Homo sapiens_hsa046621.50431120
30* Glioma_Homo sapiens_hsa052141.46220063
31* Gap junction_Homo sapiens_hsa045401.45318251
32Nitrogen metabolism_Homo sapiens_hsa009101.44413714
33Taste transduction_Homo sapiens_hsa047421.39122674
34* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37152820
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36851507
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36077550
37* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29870342
38* Estrogen signaling pathway_Homo sapiens_hsa049151.29154724
39* Serotonergic synapse_Homo sapiens_hsa047261.27702073
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27211696
41* Osteoclast differentiation_Homo sapiens_hsa043801.26794226
42* cAMP signaling pathway_Homo sapiens_hsa040241.25594610
43* Oocyte meiosis_Homo sapiens_hsa041141.23493957
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12414500
45* ErbB signaling pathway_Homo sapiens_hsa040121.10581850
46* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10151513
47* Prolactin signaling pathway_Homo sapiens_hsa049171.10048549
48* Melanogenesis_Homo sapiens_hsa049161.09664687
49* Type II diabetes mellitus_Homo sapiens_hsa049301.08598531
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08035936
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.03509173
52* Axon guidance_Homo sapiens_hsa043600.99381775
53Amoebiasis_Homo sapiens_hsa051460.98520346
54* Focal adhesion_Homo sapiens_hsa045100.94887335
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94138766
56* VEGF signaling pathway_Homo sapiens_hsa043700.92476943
57* Neurotrophin signaling pathway_Homo sapiens_hsa047220.92117499
58Collecting duct acid secretion_Homo sapiens_hsa049660.92082508
59* Phospholipase D signaling pathway_Homo sapiens_hsa040720.91843532
60* Hepatitis B_Homo sapiens_hsa051610.90297693
61Thyroid hormone synthesis_Homo sapiens_hsa049180.90035102
62Pancreatic secretion_Homo sapiens_hsa049720.89484262
63* Leishmaniasis_Homo sapiens_hsa051400.88145949
64* HIF-1 signaling pathway_Homo sapiens_hsa040660.86763183
65* Vascular smooth muscle contraction_Homo sapiens_hsa042700.86421763
66* mTOR signaling pathway_Homo sapiens_hsa041500.85126768
67* T cell receptor signaling pathway_Homo sapiens_hsa046600.84484451
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81570988
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81472275
70Other glycan degradation_Homo sapiens_hsa005110.80621742
71* Adherens junction_Homo sapiens_hsa045200.79318724
72* Choline metabolism in cancer_Homo sapiens_hsa052310.79247389
73* Tuberculosis_Homo sapiens_hsa051520.79242287
74* Prion diseases_Homo sapiens_hsa050200.79144083
75Glucagon signaling pathway_Homo sapiens_hsa049220.78670273
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78367001
77* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78362511
78* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77912748
79* Non-small cell lung cancer_Homo sapiens_hsa052230.77747617
80* MicroRNAs in cancer_Homo sapiens_hsa052060.76347328
81* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76178581
82* MAPK signaling pathway_Homo sapiens_hsa040100.75615922
83Vibrio cholerae infection_Homo sapiens_hsa051100.74872374
84* Dorso-ventral axis formation_Homo sapiens_hsa043200.74236016
85Dilated cardiomyopathy_Homo sapiens_hsa054140.73562769
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73562284
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73361371
88* Prostate cancer_Homo sapiens_hsa052150.72940172
89* Alcoholism_Homo sapiens_hsa050340.70836901
90* Rap1 signaling pathway_Homo sapiens_hsa040150.70682416
91Measles_Homo sapiens_hsa051620.68208482
92* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67213666
93Small cell lung cancer_Homo sapiens_hsa052220.66525146
94* FoxO signaling pathway_Homo sapiens_hsa040680.66009538
95* Toxoplasmosis_Homo sapiens_hsa051450.65375585
96* Thyroid cancer_Homo sapiens_hsa052160.64045813
97* Endometrial cancer_Homo sapiens_hsa052130.62959379
98Endocytosis_Homo sapiens_hsa041440.62466394
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60413714
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60299625
101Insulin resistance_Homo sapiens_hsa049310.60022402
102Malaria_Homo sapiens_hsa051440.59893413
103AMPK signaling pathway_Homo sapiens_hsa041520.59175717
104* Ras signaling pathway_Homo sapiens_hsa040140.57263106
105* Insulin signaling pathway_Homo sapiens_hsa049100.57241285
106* Sphingolipid signaling pathway_Homo sapiens_hsa040710.57067921
107Inositol phosphate metabolism_Homo sapiens_hsa005620.57055830
108Wnt signaling pathway_Homo sapiens_hsa043100.55623193
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55072355
110Cardiac muscle contraction_Homo sapiens_hsa042600.52897036
111* Renal cell carcinoma_Homo sapiens_hsa052110.51865306
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51207244
113Type I diabetes mellitus_Homo sapiens_hsa049400.48017212
114* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47548498
115* Colorectal cancer_Homo sapiens_hsa052100.46849173
116Bile secretion_Homo sapiens_hsa049760.46292721
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45959112
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45099907
119* Platelet activation_Homo sapiens_hsa046110.43199288
120* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42342418
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41838204
122* Central carbon metabolism in cancer_Homo sapiens_hsa052300.41141155
123* Chemokine signaling pathway_Homo sapiens_hsa040620.41089142
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39212587
125Phototransduction_Homo sapiens_hsa047440.36731455
126* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35193256
127* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35142371
128Circadian rhythm_Homo sapiens_hsa047100.33246486
129Tight junction_Homo sapiens_hsa045300.33183020
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32952551
131* Proteoglycans in cancer_Homo sapiens_hsa052050.31706233
132African trypanosomiasis_Homo sapiens_hsa051430.31101057

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