MAPK10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.64873563
2synaptic vesicle exocytosis (GO:0016079)5.61300804
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57601791
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.42541483
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.27660212
6glutamate secretion (GO:0014047)5.16987125
7pyrimidine nucleobase catabolic process (GO:0006208)5.15464845
8neuron cell-cell adhesion (GO:0007158)5.11705758
9regulation of synaptic vesicle exocytosis (GO:2000300)5.03310923
10regulation of glutamate receptor signaling pathway (GO:1900449)5.00082315
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.94336476
12protein localization to synapse (GO:0035418)4.86723296
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.84257527
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.79885421
15neuronal action potential propagation (GO:0019227)4.73650577
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73092832
17synaptic vesicle maturation (GO:0016188)4.68108384
18locomotory exploration behavior (GO:0035641)4.67287553
19regulation of synaptic vesicle transport (GO:1902803)4.50429873
20glutamate receptor signaling pathway (GO:0007215)4.42239441
21nucleobase catabolic process (GO:0046113)4.38307759
22synaptic transmission, glutamatergic (GO:0035249)4.32638048
23neuron-neuron synaptic transmission (GO:0007270)4.31198959
24neurotransmitter secretion (GO:0007269)4.30541613
25presynaptic membrane assembly (GO:0097105)4.17186053
26neurotransmitter-gated ion channel clustering (GO:0072578)4.17034927
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04047689
28exploration behavior (GO:0035640)4.03180560
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.01247130
30regulation of neuronal synaptic plasticity (GO:0048168)3.99383645
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91338131
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.90132414
33presynaptic membrane organization (GO:0097090)3.87907452
34postsynaptic membrane organization (GO:0001941)3.85093700
35regulation of postsynaptic membrane potential (GO:0060078)3.75715307
36neuron recognition (GO:0008038)3.73584974
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73115691
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72738490
39long-term synaptic potentiation (GO:0060291)3.72686708
40proline transport (GO:0015824)3.70206977
41positive regulation of membrane potential (GO:0045838)3.63398801
42neurotransmitter transport (GO:0006836)3.59439032
43long-term memory (GO:0007616)3.58771310
44synaptic vesicle endocytosis (GO:0048488)3.55434821
45positive regulation of synapse maturation (GO:0090129)3.55171553
46gamma-aminobutyric acid transport (GO:0015812)3.55065065
47response to histamine (GO:0034776)3.54693765
48regulation of synaptic plasticity (GO:0048167)3.52859087
49regulation of neurotransmitter secretion (GO:0046928)3.52560891
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.51500702
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45086391
52neuronal ion channel clustering (GO:0045161)3.43815902
53regulation of synapse structural plasticity (GO:0051823)3.43680273
54establishment of mitochondrion localization (GO:0051654)3.41232366
55regulation of vesicle fusion (GO:0031338)3.39180031
56cerebellar Purkinje cell differentiation (GO:0021702)3.38686833
57axonal fasciculation (GO:0007413)3.35618228
58dendritic spine morphogenesis (GO:0060997)3.34646817
59startle response (GO:0001964)3.34316351
60positive regulation of neurotransmitter secretion (GO:0001956)3.33607741
61transmission of nerve impulse (GO:0019226)3.32662286
62positive regulation of neurotransmitter transport (GO:0051590)3.32088075
63regulation of neurotransmitter levels (GO:0001505)3.30045510
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29737657
65layer formation in cerebral cortex (GO:0021819)3.28925032
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27024988
67regulation of neurotransmitter transport (GO:0051588)3.26676052
68behavioral response to cocaine (GO:0048148)3.24243558
69membrane depolarization (GO:0051899)3.23694092
70glycosphingolipid biosynthetic process (GO:0006688)3.23389670
71cerebellar granule cell differentiation (GO:0021707)3.22815216
72regulation of dendritic spine morphogenesis (GO:0061001)3.19914858
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18344603
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17996090
75regulation of glutamate secretion (GO:0014048)3.17573995
76central nervous system projection neuron axonogenesis (GO:0021952)3.17437523
77dendrite morphogenesis (GO:0048813)3.16419340
78cellular potassium ion homeostasis (GO:0030007)3.14843708
79behavioral fear response (GO:0001662)3.13269917
80behavioral defense response (GO:0002209)3.13269917
81activation of protein kinase A activity (GO:0034199)3.11530266
82membrane depolarization during action potential (GO:0086010)3.11325889
83membrane hyperpolarization (GO:0060081)3.10864586
84synaptic transmission (GO:0007268)3.08923493
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08696671
86fear response (GO:0042596)3.08435316
87G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07960072
88innervation (GO:0060384)3.07818653
89retinal ganglion cell axon guidance (GO:0031290)3.07174450
90detection of calcium ion (GO:0005513)3.06433436
91learning (GO:0007612)3.06007756
92positive regulation of synapse assembly (GO:0051965)3.05608159
93positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04725122
94positive regulation of synaptic transmission (GO:0050806)3.04301422
95regulation of synaptic transmission (GO:0050804)3.03554513
96synapse assembly (GO:0007416)3.03018877
97neuromuscular process controlling posture (GO:0050884)3.01805795
98auditory behavior (GO:0031223)3.00729226
99negative regulation of dendrite morphogenesis (GO:0050774)3.00612734
100cell migration in hindbrain (GO:0021535)3.00458336
101regulation of synapse maturation (GO:0090128)2.97664676
102mechanosensory behavior (GO:0007638)2.96105828
103neuromuscular synaptic transmission (GO:0007274)2.95397226
104establishment of synaptic vesicle localization (GO:0097480)2.93817117
105synaptic vesicle transport (GO:0048489)2.93817117
106response to auditory stimulus (GO:0010996)2.93143887
107long term synaptic depression (GO:0060292)2.92381797
108regulation of respiratory system process (GO:0044065)2.89409358
109energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.88237722
110ATP hydrolysis coupled proton transport (GO:0015991)2.88237722
111adult walking behavior (GO:0007628)2.88069752
112central nervous system myelination (GO:0022010)2.87195945
113axon ensheathment in central nervous system (GO:0032291)2.87195945
114protein localization to cilium (GO:0061512)2.86840281
115synapse organization (GO:0050808)2.85169241
116nonmotile primary cilium assembly (GO:0035058)2.81231219
117epithelial cilium movement (GO:0003351)2.74122881
118positive regulation of dendritic spine development (GO:0060999)2.73759336
119positive regulation of dendritic spine morphogenesis (GO:0061003)2.73434650
120C4-dicarboxylate transport (GO:0015740)2.72833930
121regulation of synapse assembly (GO:0051963)2.71594507
122central nervous system neuron axonogenesis (GO:0021955)2.69824001
123behavioral response to nicotine (GO:0035095)2.69672986
124calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69289413
125regulation of dendritic spine development (GO:0060998)2.66814253
126hippocampus development (GO:0021766)2.66625787
127cilium movement (GO:0003341)2.66239098
128cochlea development (GO:0090102)2.65420448
129protein polyglutamylation (GO:0018095)2.64090111
130dendritic spine organization (GO:0097061)2.63474424
131neurofilament cytoskeleton organization (GO:0060052)2.63119321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.35652833
2GBX2_23144817_ChIP-Seq_PC3_Human4.24056639
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13920401
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01306121
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98559997
6REST_21632747_ChIP-Seq_MESCs_Mouse2.71370279
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62202525
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57941593
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57941593
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53673381
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.49630157
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49003419
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44254429
14TAF15_26573619_Chip-Seq_HEK293_Human2.41356752
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36445057
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34877532
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.29245419
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.24720247
19DROSHA_22980978_ChIP-Seq_HELA_Human2.16849700
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.16644795
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13873605
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08754988
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.07266027
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05970646
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.05407133
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04474084
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02061097
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00942077
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90107856
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87255309
31SMAD4_21799915_ChIP-Seq_A2780_Human1.86471113
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84406390
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83899011
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79776765
35AR_21572438_ChIP-Seq_LNCaP_Human1.77979074
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74602036
37* P300_19829295_ChIP-Seq_ESCs_Human1.72843217
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63072910
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62731506
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59434412
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58074221
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.52609698
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48309832
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47376813
45* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45313615
46VDR_22108803_ChIP-Seq_LS180_Human1.45311415
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44287432
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44034457
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43946180
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.42478360
51AR_25329375_ChIP-Seq_VCAP_Human1.39455019
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38198030
53ZNF274_21170338_ChIP-Seq_K562_Hela1.38129039
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38058965
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37835243
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.34743394
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32891132
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.31707549
59* FUS_26573619_Chip-Seq_HEK293_Human1.31416520
60RNF2_27304074_Chip-Seq_NSC_Mouse1.30851344
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30694669
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30533314
63STAT3_23295773_ChIP-Seq_U87_Human1.30189006
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23983817
65EWS_26573619_Chip-Seq_HEK293_Human1.22771299
66IGF1R_20145208_ChIP-Seq_DFB_Human1.22268293
67TCF4_23295773_ChIP-Seq_U87_Human1.19495589
68CBP_20019798_ChIP-Seq_JUKART_Human1.18998923
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18998923
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.17943110
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17861304
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13495580
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13202391
74AR_19668381_ChIP-Seq_PC3_Human1.12923396
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.12842348
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12533248
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.12391745
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11911363
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.10667022
80ER_23166858_ChIP-Seq_MCF-7_Human1.10623539
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.10498343
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10295281
83RUNX2_22187159_ChIP-Seq_PCA_Human1.10281250
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06709513
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05848197
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05845829
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.05826771
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05544113
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05504175
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05036668
91* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03968782
92* JUN_21703547_ChIP-Seq_K562_Human1.03683818
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01543493
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00173386
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99194368
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98933293
97BCAT_22108803_ChIP-Seq_LS180_Human0.98641889
98AHR_22903824_ChIP-Seq_MCF-7_Human0.98641238
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.98404631
100SOX9_26525672_Chip-Seq_HEART_Mouse0.98343933
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98043698
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97911337
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97691564
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97691564
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97324798
106* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96790759
107P53_22387025_ChIP-Seq_ESCs_Mouse0.96696216
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96383795
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96262836
110* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93719934
111TP53_16413492_ChIP-PET_HCT116_Human0.92526163
112KDM2B_26808549_Chip-Seq_REH_Human0.92041071
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91190991
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.91129593
115* E2F1_18555785_Chip-Seq_ESCs_Mouse0.91018819
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90162864
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90079803
118* TP53_18474530_ChIP-ChIP_U2OS_Human0.89884283
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.89411626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.83901283
2MP0003880_abnormal_central_pattern5.31497454
3MP0003635_abnormal_synaptic_transmissio4.03841548
4MP0004270_analgesia3.53914125
5* MP0009745_abnormal_behavioral_response3.44103555
6MP0001968_abnormal_touch/_nociception3.32662615
7MP0002063_abnormal_learning/memory/cond3.28270001
8MP0009046_muscle_twitch3.24331536
9* MP0002064_seizures3.20543144
10MP0002572_abnormal_emotion/affect_behav2.94669381
11MP0002736_abnormal_nociception_after2.87427751
12MP0002272_abnormal_nervous_system2.70140963
13MP0002822_catalepsy2.67507811
14MP0002734_abnormal_mechanical_nocicepti2.64733950
15MP0002735_abnormal_chemical_nociception2.62246126
16MP0001486_abnormal_startle_reflex2.52466349
17MP0001501_abnormal_sleep_pattern2.47400813
18MP0001440_abnormal_grooming_behavior2.32647401
19MP0005423_abnormal_somatic_nervous2.32590374
20MP0006276_abnormal_autonomic_nervous2.15902284
21MP0002067_abnormal_sensory_capabilities2.13089073
22MP0002733_abnormal_thermal_nociception2.05685911
23MP0001970_abnormal_pain_threshold2.04133475
24MP0005646_abnormal_pituitary_gland1.87767598
25MP0001984_abnormal_olfaction1.86953149
26MP0002184_abnormal_innervation1.85779321
27MP0001529_abnormal_vocalization1.79128615
28MP0004924_abnormal_behavior1.78983787
29MP0005386_behavior/neurological_phenoty1.78983787
30MP0003787_abnormal_imprinting1.78042464
31MP0000778_abnormal_nervous_system1.77767278
32MP0002557_abnormal_social/conspecific_i1.76946307
33MP0008569_lethality_at_weaning1.72496818
34MP0009780_abnormal_chondrocyte_physiolo1.70082706
35MP0003329_amyloid_beta_deposits1.58786773
36MP0002102_abnormal_ear_morphology1.58635131
37* MP0004811_abnormal_neuron_physiology1.56778417
38MP0003879_abnormal_hair_cell1.55301656
39MP0004858_abnormal_nervous_system1.54747295
40MP0002837_dystrophic_cardiac_calcinosis1.52192795
41MP0002909_abnormal_adrenal_gland1.45275559
42MP0003122_maternal_imprinting1.44349281
43MP0001188_hyperpigmentation1.43405785
44MP0000955_abnormal_spinal_cord1.42639233
45MP0005645_abnormal_hypothalamus_physiol1.39913088
46MP0010386_abnormal_urinary_bladder1.37439685
47* MP0002066_abnormal_motor_capabilities/c1.37433383
48MP0004142_abnormal_muscle_tone1.35998012
49* MP0002882_abnormal_neuron_morphology1.33723737
50* MP0001905_abnormal_dopamine_level1.32488643
51MP0001502_abnormal_circadian_rhythm1.25910981
52MP0003633_abnormal_nervous_system1.25747922
53MP0005253_abnormal_eye_physiology1.20509568
54MP0002653_abnormal_ependyma_morphology1.20191119
55MP0008789_abnormal_olfactory_epithelium1.17620599
56MP0004133_heterotaxia1.17307812
57MP0006072_abnormal_retinal_apoptosis1.11238415
58MP0000566_synostosis1.10836319
59MP0003631_nervous_system_phenotype1.07692364
60MP0000751_myopathy1.07680915
61MP0002876_abnormal_thyroid_physiology1.06368173
62MP0003938_abnormal_ear_development1.05902079
63MP0008872_abnormal_physiological_respon1.04775128
64MP0004885_abnormal_endolymph1.04020237
65MP0002152_abnormal_brain_morphology1.03738325
66MP0002234_abnormal_pharynx_morphology1.03440198
67MP0001986_abnormal_taste_sensitivity1.02295101
68MP0005551_abnormal_eye_electrophysiolog0.96571122
69MP0004145_abnormal_muscle_electrophysio0.95135733
70MP0005394_taste/olfaction_phenotype0.94729107
71MP0005499_abnormal_olfactory_system0.94729107
72MP0002229_neurodegeneration0.94368124
73MP0001963_abnormal_hearing_physiology0.92695419
74MP0004742_abnormal_vestibular_system0.92377387
75MP0002069_abnormal_eating/drinking_beha0.91373864
76MP0003283_abnormal_digestive_organ0.91294692
77MP0000013_abnormal_adipose_tissue0.90144614
78MP0004147_increased_porphyrin_level0.88831831
79MP0004085_abnormal_heartbeat0.86737977
80MP0001299_abnormal_eye_distance/0.86421463
81MP0005535_abnormal_body_temperature0.85809566
82MP0005187_abnormal_penis_morphology0.85056754
83MP0002638_abnormal_pupillary_reflex0.84367756
84MP0002751_abnormal_autonomic_nervous0.84256071
85MP0000049_abnormal_middle_ear0.82904590
86MP0005248_abnormal_Harderian_gland0.80958974
87MP0003119_abnormal_digestive_system0.80237240
88MP0000631_abnormal_neuroendocrine_gland0.80084540
89MP0004484_altered_response_of0.79999454
90MP0000569_abnormal_digit_pigmentation0.79640886
91MP0004215_abnormal_myocardial_fiber0.78124721
92MP0005167_abnormal_blood-brain_barrier0.75245929
93MP0003136_yellow_coat_color0.75143470
94* MP0008874_decreased_physiological_sensi0.75069284
95* MP0002752_abnormal_somatic_nervous0.74717610
96MP0001664_abnormal_digestion0.74217954
97MP0003632_abnormal_nervous_system0.70834025
98MP0002233_abnormal_nose_morphology0.70810558
99MP0003646_muscle_fatigue0.69758179
100MP0005195_abnormal_posterior_eye0.69517307
101MP0004043_abnormal_pH_regulation0.69432066
102MP0003634_abnormal_glial_cell0.68842116
103MP0001177_atelectasis0.68683362
104MP0005171_absent_coat_pigmentation0.67440428
105MP0005409_darkened_coat_color0.67007600
106MP0001485_abnormal_pinna_reflex0.66855311
107MP0000604_amyloidosis0.62358355
108MP0008877_abnormal_DNA_methylation0.58818693
109MP0000026_abnormal_inner_ear0.58182443
110MP0003137_abnormal_impulse_conducting0.56936760
111MP0001943_abnormal_respiration0.56788360
112MP0004233_abnormal_muscle_weight0.55722769
113MP0000920_abnormal_myelination0.53250214
114MP0002090_abnormal_vision0.51335981
115MP0003121_genomic_imprinting0.51217350
116MP0003690_abnormal_glial_cell0.51045188
117MP0002082_postnatal_lethality0.49329754
118MP0010770_preweaning_lethality0.49329754
119MP0010769_abnormal_survival0.48911865
120MP0003183_abnormal_peptide_metabolism0.48547993
121MP0003861_abnormal_nervous_system0.48271045
122MP0006292_abnormal_olfactory_placode0.47760087

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.51442498
2Myokymia (HP:0002411)5.91391246
3Focal seizures (HP:0007359)5.88792779
4Atonic seizures (HP:0010819)5.56570269
5Epileptic encephalopathy (HP:0200134)5.47465065
6Febrile seizures (HP:0002373)5.16235988
7Visual hallucinations (HP:0002367)4.86870374
8Hyperventilation (HP:0002883)4.68855439
9Absence seizures (HP:0002121)4.61835139
10Dialeptic seizures (HP:0011146)4.26706393
11Progressive cerebellar ataxia (HP:0002073)4.26699976
12Generalized tonic-clonic seizures (HP:0002069)4.01942193
13Broad-based gait (HP:0002136)3.76873738
14Amblyopia (HP:0000646)3.59191696
15Gaze-evoked nystagmus (HP:0000640)3.36889841
16Action tremor (HP:0002345)3.20214997
17Impaired vibration sensation in the lower limbs (HP:0002166)3.13609916
18Poor eye contact (HP:0000817)3.12699661
19Truncal ataxia (HP:0002078)3.10234885
20Dysdiadochokinesis (HP:0002075)2.92724528
21Abnormal eating behavior (HP:0100738)2.91413482
22Supranuclear gaze palsy (HP:0000605)2.90731042
23Anxiety (HP:0000739)2.86686635
24Epileptiform EEG discharges (HP:0011182)2.82080315
25Dysmetria (HP:0001310)2.81391046
26Abnormal social behavior (HP:0012433)2.81138216
27Impaired social interactions (HP:0000735)2.81138216
28Drooling (HP:0002307)2.80838327
29Excessive salivation (HP:0003781)2.80838327
30Depression (HP:0000716)2.80575542
31Progressive inability to walk (HP:0002505)2.74422614
32Abnormality of the labia minora (HP:0012880)2.72097202
33Urinary bladder sphincter dysfunction (HP:0002839)2.67005976
34Pheochromocytoma (HP:0002666)2.63897063
35Gait imbalance (HP:0002141)2.61751490
36Absent speech (HP:0001344)2.58530105
37EEG with generalized epileptiform discharges (HP:0011198)2.57728695
38Diplopia (HP:0000651)2.57067852
39Abnormality of binocular vision (HP:0011514)2.57067852
40True hermaphroditism (HP:0010459)2.55035103
41Inability to walk (HP:0002540)2.54468077
42Ankle clonus (HP:0011448)2.54153092
43Impaired smooth pursuit (HP:0007772)2.52625073
44Hemiparesis (HP:0001269)2.52053949
45Pancreatic fibrosis (HP:0100732)2.48438362
46Limb dystonia (HP:0002451)2.45504558
47Polyphagia (HP:0002591)2.45445882
48Termporal pattern (HP:0011008)2.41863359
49Insidious onset (HP:0003587)2.41863359
50Neuroendocrine neoplasm (HP:0100634)2.40307825
51Nephronophthisis (HP:0000090)2.40294942
52Hypsarrhythmia (HP:0002521)2.39446348
53Abnormal hair whorl (HP:0010721)2.39315352
54Lissencephaly (HP:0001339)2.38955714
55Pancreatic cysts (HP:0001737)2.38684802
56Abnormal ciliary motility (HP:0012262)2.37865433
57Split foot (HP:0001839)2.36342760
58Abnormal respiratory epithelium morphology (HP:0012253)2.34746614
59Abnormal respiratory motile cilium morphology (HP:0005938)2.34746614
60Genetic anticipation (HP:0003743)2.34237304
61Medial flaring of the eyebrow (HP:0010747)2.33429471
62Scanning speech (HP:0002168)2.32771655
63Congenital primary aphakia (HP:0007707)2.32740062
64Postural instability (HP:0002172)2.31703305
65Protruding tongue (HP:0010808)2.30299429
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29160483
67Cerebral inclusion bodies (HP:0100314)2.28973588
68Urinary urgency (HP:0000012)2.25175299
69Bradykinesia (HP:0002067)2.23771230
70Dysmetric saccades (HP:0000641)2.22941602
71Spastic tetraplegia (HP:0002510)2.22224477
72Fetal akinesia sequence (HP:0001989)2.21827793
73Impaired vibratory sensation (HP:0002495)2.21207481
74Abnormality of midbrain morphology (HP:0002418)2.21141997
75Molar tooth sign on MRI (HP:0002419)2.21141997
76Spastic gait (HP:0002064)2.20624920
77Abnormal respiratory motile cilium physiology (HP:0012261)2.19901738
78Abnormality of the lower motor neuron (HP:0002366)2.19899693
79Amyotrophic lateral sclerosis (HP:0007354)2.18818341
80Stereotypic behavior (HP:0000733)2.17623561
81Abnormality of the corticospinal tract (HP:0002492)2.17023732
82Nephrogenic diabetes insipidus (HP:0009806)2.16499826
83Abnormality of ocular smooth pursuit (HP:0000617)2.14199540
84Status epilepticus (HP:0002133)2.14024735
85Blue irides (HP:0000635)2.11064488
86Rhinitis (HP:0012384)2.10080945
87Specific learning disability (HP:0001328)2.08654989
88Oligodactyly (hands) (HP:0001180)2.08505822
89Generalized myoclonic seizures (HP:0002123)2.08498325
90Pachygyria (HP:0001302)2.07772852
91Sleep apnea (HP:0010535)2.05918668
92Acute necrotizing encephalopathy (HP:0006965)2.04316274
93Mutism (HP:0002300)2.03135339
94Intention tremor (HP:0002080)2.02627647
95Delusions (HP:0000746)2.02249145
96Absent/shortened dynein arms (HP:0200106)2.00560000
97Dynein arm defect of respiratory motile cilia (HP:0012255)2.00560000
98Focal dystonia (HP:0004373)2.00019551
99Gait ataxia (HP:0002066)1.99868555
100Failure to thrive in infancy (HP:0001531)1.99792378
101Postaxial hand polydactyly (HP:0001162)1.99145836
102Neurofibrillary tangles (HP:0002185)1.99116035
103Torticollis (HP:0000473)1.97304614
104Optic nerve hypoplasia (HP:0000609)1.97098010
105Progressive macrocephaly (HP:0004481)1.96558624
106Hepatoblastoma (HP:0002884)1.96257360
107Abnormality of the renal medulla (HP:0100957)1.95540813
108Abnormality of salivation (HP:0100755)1.94877690
109Lower limb muscle weakness (HP:0007340)1.93763887
110Abnormal mitochondria in muscle tissue (HP:0008316)1.93703239
111Incomplete penetrance (HP:0003829)1.91588869
112Agitation (HP:0000713)1.90674674
113Genital tract atresia (HP:0001827)1.88331669
114Psychosis (HP:0000709)1.86665288
115Hyperthyroidism (HP:0000836)1.86545735
116Type II lissencephaly (HP:0007260)1.85761119
117Esotropia (HP:0000565)1.85167909
118Morphological abnormality of the pyramidal tract (HP:0002062)1.83971373
119Hemiplegia (HP:0002301)1.83922655
120Vaginal atresia (HP:0000148)1.81721553
121Intestinal atresia (HP:0011100)1.81208211
122Occipital encephalocele (HP:0002085)1.80899128
123Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80467799
124Hypoplasia of the brainstem (HP:0002365)1.80467799
125Hypoplasia of the corpus callosum (HP:0002079)1.80171194
126Hypoventilation (HP:0002791)1.79639579
127Poor suck (HP:0002033)1.78929779
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78390906
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.78390906
130Papilledema (HP:0001085)1.77805569
131Chronic hepatic failure (HP:0100626)1.77368194
132Thickened helices (HP:0000391)1.75944956
133Broad foot (HP:0001769)1.75578326
134Cystic liver disease (HP:0006706)1.75478991
135Poor coordination (HP:0002370)1.74178368
136Retinal dysplasia (HP:0007973)1.73320560
137Muscular hypotonia of the trunk (HP:0008936)1.70324415
138Tubulointerstitial nephritis (HP:0001970)1.66912388
139Narrow forehead (HP:0000341)1.65705942
140Labial hypoplasia (HP:0000066)1.62575216
141Aplasia/Hypoplasia of the lens (HP:0008063)1.61671077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.54687593
2EPHA44.24693700
3CASK3.89833430
4MAP3K93.23104809
5MAP3K123.17169485
6MINK12.53721718
7MARK12.51370044
8DAPK22.49606284
9RIPK42.45426221
10MAP4K22.43638021
11PLK22.11026111
12CDK192.08409681
13PNCK2.04610312
14* MAP3K42.02588796
15DAPK11.98167803
16NTRK21.92528155
17FRK1.87876598
18TRIM281.84040708
19DYRK21.77795927
20* MAP2K71.76819478
21PAK61.76722239
22GRK51.71591923
23NTRK11.57191046
24PRPF4B1.55286387
25MAPK131.51214721
26KSR21.47774663
27EPHA31.47560694
28KSR11.46750192
29TNIK1.42101314
30* CDK51.40914505
31ARAF1.38250813
32PRKCG1.32940306
33CSNK1G31.32803702
34CAMKK11.27915099
35* MAP2K41.27062132
36OXSR11.26658604
37CSNK1A1L1.25484226
38BMPR21.23995646
39AKT31.22631556
40PRKD31.21043688
41CAMK2A1.20959770
42FGFR21.19196181
43CSNK1G11.17865813
44PTK2B1.15390312
45SIK21.15257425
46FES1.14590224
47SGK2231.14213529
48SGK4941.14213529
49CAMKK21.13664795
50NME11.12254006
51CCNB11.09543075
52SGK21.09308857
53ERBB31.05777526
54CAMK2B1.02374224
55STK381.01585901
56GRK11.01412214
57UHMK10.95280232
58SIK30.93678556
59MAP3K20.87217588
60CDK180.86531003
61CAMK10.82164445
62BMPR1B0.81224355
63CDK150.81051930
64GRK70.80916167
65FGR0.79509074
66PKN10.79506076
67MAP3K130.79405400
68CDK140.78691980
69MAPK150.74597536
70PRKCE0.74481888
71SGK30.73454534
72DYRK1A0.72701126
73STK110.72146285
74STK390.70810367
75PHKG10.70231811
76PHKG20.70231811
77CDK11A0.69610300
78INSRR0.69222346
79SGK10.68555669
80EPHB20.68104662
81TNK20.64187414
82RAF10.60568177
83CAMK2D0.60522264
84BRAF0.60088844
85PAK30.59844509
86DYRK30.59622978
87STK38L0.59393305
88TYRO30.58155520
89PRKCH0.57465457
90FER0.57349867
91LATS20.56580964
92PINK10.56109936
93RET0.55655956
94CSNK1G20.55033974
95WNK40.52332951
96CAMK2G0.51726125
97ADRBK10.51721680
98DYRK1B0.51024981
99WNK30.50392670
100BCR0.49235315
101MAP3K60.49114794
102PRKG10.48059829
103CDK30.48040879
104CSNK1A10.47856711
105CSNK1D0.47716465
106DAPK30.46507189
107PDK10.46425759
108LIMK10.45872628
109TSSK60.44909043
110MAP2K10.44778811
111PDK30.44507002
112PDK40.44507002
113MAP3K10.43809256
114PRKAA10.43621320
115PRKCZ0.43525732
116CAMK40.43486248
117PDPK10.43435454
118MARK20.42515643
119CSNK1E0.42154187
120MUSK0.41832529
121RPS6KA30.41653983
122ROCK20.41507125
123ADRBK20.41254323
124CAMK1G0.41232832
125ERBB20.41220316
126LMTK20.40285496
127PRKACB0.37859031
128PRKACA0.37569828
129WNK10.37275794
130FYN0.36132594
131MAPK100.35850827
132PRKCA0.34051041
133PRKCB0.32588706
134MKNK20.30566088
135RPS6KA40.30337148

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.18418944
2Synaptic vesicle cycle_Homo sapiens_hsa047213.63300648
3* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83043364
4Long-term potentiation_Homo sapiens_hsa047202.75671046
5Olfactory transduction_Homo sapiens_hsa047402.72927966
6GABAergic synapse_Homo sapiens_hsa047272.69935882
7Circadian entrainment_Homo sapiens_hsa047132.69522426
8Amphetamine addiction_Homo sapiens_hsa050312.61587984
9Glutamatergic synapse_Homo sapiens_hsa047242.59494942
10Morphine addiction_Homo sapiens_hsa050322.57782703
11Collecting duct acid secretion_Homo sapiens_hsa049662.46105725
12Salivary secretion_Homo sapiens_hsa049702.19555210
13* Dopaminergic synapse_Homo sapiens_hsa047282.15311922
14Taste transduction_Homo sapiens_hsa047422.14757388
15Insulin secretion_Homo sapiens_hsa049112.03338220
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00001600
17Serotonergic synapse_Homo sapiens_hsa047261.89794261
18Renin secretion_Homo sapiens_hsa049241.82765833
19Gastric acid secretion_Homo sapiens_hsa049711.82415079
20Long-term depression_Homo sapiens_hsa047301.79986847
21Cholinergic synapse_Homo sapiens_hsa047251.77335820
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69621054
23Calcium signaling pathway_Homo sapiens_hsa040201.69323644
24Cocaine addiction_Homo sapiens_hsa050301.62000813
25Oxytocin signaling pathway_Homo sapiens_hsa049211.59624990
26Butanoate metabolism_Homo sapiens_hsa006501.59560431
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50525342
28Vibrio cholerae infection_Homo sapiens_hsa051101.48835247
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47378806
30Oxidative phosphorylation_Homo sapiens_hsa001901.46398992
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34994755
32Gap junction_Homo sapiens_hsa045401.28477945
33Cardiac muscle contraction_Homo sapiens_hsa042601.27555038
34* GnRH signaling pathway_Homo sapiens_hsa049121.25444029
35* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20924335
36Alzheimers disease_Homo sapiens_hsa050101.19643883
37Phototransduction_Homo sapiens_hsa047441.14799525
38* cAMP signaling pathway_Homo sapiens_hsa040241.14188120
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13132751
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10213799
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09224871
42Axon guidance_Homo sapiens_hsa043601.03831314
43Estrogen signaling pathway_Homo sapiens_hsa049151.01777471
44Parkinsons disease_Homo sapiens_hsa050121.01244363
45* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99704472
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99210244
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98504225
48Melanogenesis_Homo sapiens_hsa049160.95169107
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94462562
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93259713
51beta-Alanine metabolism_Homo sapiens_hsa004100.92089945
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.92066089
53Glioma_Homo sapiens_hsa052140.91350709
54Hedgehog signaling pathway_Homo sapiens_hsa043400.89440680
55Protein export_Homo sapiens_hsa030600.83969265
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83808138
57* ErbB signaling pathway_Homo sapiens_hsa040120.82546696
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82027294
59Pancreatic secretion_Homo sapiens_hsa049720.81765097
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.79072498
61* Type II diabetes mellitus_Homo sapiens_hsa049300.77809902
62Oocyte meiosis_Homo sapiens_hsa041140.76861383
63Huntingtons disease_Homo sapiens_hsa050160.74269602
64Nitrogen metabolism_Homo sapiens_hsa009100.70695991
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69903724
66Thyroid hormone synthesis_Homo sapiens_hsa049180.67907147
67Steroid biosynthesis_Homo sapiens_hsa001000.67881829
68Propanoate metabolism_Homo sapiens_hsa006400.67559797
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67528213
70Hippo signaling pathway_Homo sapiens_hsa043900.66273922
71Dorso-ventral axis formation_Homo sapiens_hsa043200.66017516
72Ether lipid metabolism_Homo sapiens_hsa005650.65875757
73Basal cell carcinoma_Homo sapiens_hsa052170.65772224
74Dilated cardiomyopathy_Homo sapiens_hsa054140.63812984
75Type I diabetes mellitus_Homo sapiens_hsa049400.62759910
76* MAPK signaling pathway_Homo sapiens_hsa040100.61458340
77Glucagon signaling pathway_Homo sapiens_hsa049220.60710604
78Rheumatoid arthritis_Homo sapiens_hsa053230.60426534
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.59087777
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55784512
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53215003
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52683110
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51187505
84Vitamin B6 metabolism_Homo sapiens_hsa007500.50747495
85African trypanosomiasis_Homo sapiens_hsa051430.50621777
86* Ras signaling pathway_Homo sapiens_hsa040140.50049251
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49987751
88Alcoholism_Homo sapiens_hsa050340.48690806
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48684297
90Circadian rhythm_Homo sapiens_hsa047100.48195532
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47986314
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47834861
93Histidine metabolism_Homo sapiens_hsa003400.46950721
94Inositol phosphate metabolism_Homo sapiens_hsa005620.46656105
95* Choline metabolism in cancer_Homo sapiens_hsa052310.46332375
96Tight junction_Homo sapiens_hsa045300.45509085
97Rap1 signaling pathway_Homo sapiens_hsa040150.44117303
98Peroxisome_Homo sapiens_hsa041460.43794306
99VEGF signaling pathway_Homo sapiens_hsa043700.41807933
100Linoleic acid metabolism_Homo sapiens_hsa005910.40784605
101Arginine and proline metabolism_Homo sapiens_hsa003300.38378310
102Phagosome_Homo sapiens_hsa041450.37814317
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36772342
104Fatty acid metabolism_Homo sapiens_hsa012120.36642509
105Tryptophan metabolism_Homo sapiens_hsa003800.36260137
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.34976186
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34636086
108ABC transporters_Homo sapiens_hsa020100.34367191
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33963624
110* Neurotrophin signaling pathway_Homo sapiens_hsa047220.32347340
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31847991
112Ovarian steroidogenesis_Homo sapiens_hsa049130.31148914
113Prion diseases_Homo sapiens_hsa050200.30693799
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30117053
115* Sphingolipid signaling pathway_Homo sapiens_hsa040710.30082396
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28949897
117* Wnt signaling pathway_Homo sapiens_hsa043100.28335683
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27314484
119Endocytosis_Homo sapiens_hsa041440.26589184
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25565035
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24020170
122Bile secretion_Homo sapiens_hsa049760.23504294
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23219500
124Renal cell carcinoma_Homo sapiens_hsa052110.23140174
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21919295
126mTOR signaling pathway_Homo sapiens_hsa041500.19468701
127Regulation of autophagy_Homo sapiens_hsa041400.18977620

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