MAPK14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.11725782
2detection of other organism (GO:0098543)5.01435903
3detection of molecule of bacterial origin (GO:0032490)4.96705994
4detection of external biotic stimulus (GO:0098581)4.62291363
5detection of bacterium (GO:0016045)4.60393200
6leukocyte migration involved in inflammatory response (GO:0002523)4.37548467
7macrophage activation involved in immune response (GO:0002281)4.33455152
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25351819
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.25351819
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.11119290
11detection of biotic stimulus (GO:0009595)4.02723921
12response to host immune response (GO:0052572)4.01160457
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.01160457
14positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.00256867
15positive regulation of B cell differentiation (GO:0045579)3.98670167
16positive regulation of gamma-delta T cell activation (GO:0046645)3.94927363
17response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86642559
18response to host (GO:0075136)3.86642559
19response to host defenses (GO:0052200)3.86642559
20regulation of gamma-delta T cell differentiation (GO:0045586)3.69647367
21antigen processing and presentation of endogenous antigen (GO:0019883)3.66512957
22microglial cell activation (GO:0001774)3.65146744
23neutrophil activation (GO:0042119)3.61584500
24regulation of mast cell degranulation (GO:0043304)3.54219159
25regulation of myeloid leukocyte mediated immunity (GO:0002886)3.51535663
26macrophage activation (GO:0042116)3.49808645
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.47869656
28megakaryocyte development (GO:0035855)3.46161164
29regulation of leukocyte degranulation (GO:0043300)3.44941690
30disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.44670567
31killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.44670567
32negative regulation of phagocytosis (GO:0050765)3.41313338
33production of molecular mediator involved in inflammatory response (GO:0002532)3.38257212
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37472149
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36222051
36valine metabolic process (GO:0006573)3.31074116
37regulation of B cell receptor signaling pathway (GO:0050855)3.30905454
38myeloid cell activation involved in immune response (GO:0002275)3.30309139
39definitive hemopoiesis (GO:0060216)3.30276229
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29156182
41granulocyte activation (GO:0036230)3.26116202
42alpha-linolenic acid metabolic process (GO:0036109)3.25747750
43response to interleukin-15 (GO:0070672)3.23446847
44regulation of mast cell activation involved in immune response (GO:0033006)3.22318842
45regulation of gamma-delta T cell activation (GO:0046643)3.19087822
46negative regulation of leukocyte mediated immunity (GO:0002704)3.11282906
47regulation of B cell differentiation (GO:0045577)3.11220474
48lysine metabolic process (GO:0006553)3.03763982
49lysine catabolic process (GO:0006554)3.03763982
50negative regulation of T-helper cell differentiation (GO:0045623)3.00621654
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00621654
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00592738
53Arp2/3 complex-mediated actin nucleation (GO:0034314)2.99142185
54pentose-phosphate shunt (GO:0006098)2.98877594
55germinal center formation (GO:0002467)2.97355557
56negative regulation of T cell mediated immunity (GO:0002710)2.95551789
57pinocytosis (GO:0006907)2.94412436
58defense response to fungus (GO:0050832)2.93936957
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93904936
60regulation of macrophage cytokine production (GO:0010935)2.92983455
61positive regulation of histone deacetylation (GO:0031065)2.87858868
62regulation of regulated secretory pathway (GO:1903305)2.86211590
63regulation of interferon-beta biosynthetic process (GO:0045357)2.85830590
64positive regulation of cellular amide metabolic process (GO:0034250)2.83689913
65leukocyte degranulation (GO:0043299)2.83652179
66angiogenesis involved in wound healing (GO:0060055)2.82636195
67regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81928197
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81327953
69myeloid leukocyte mediated immunity (GO:0002444)2.78541288
70antigen processing and presentation via MHC class Ib (GO:0002475)2.77953095
71negative regulation of erythrocyte differentiation (GO:0045647)2.77624545
72positive regulation of mast cell activation (GO:0033005)2.77222317
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.75655604
74negative regulation of cell killing (GO:0031342)2.75655604
75* lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74332028
76protein carboxylation (GO:0018214)2.74318085
77peptidyl-glutamic acid carboxylation (GO:0017187)2.74318085
78respiratory burst (GO:0045730)2.74238834
79* response to muramyl dipeptide (GO:0032495)2.74040248
80regulation of mast cell activation (GO:0033003)2.73795597
81macrophage differentiation (GO:0030225)2.73462024
82hypotonic response (GO:0006971)2.73323519
83neutrophil mediated immunity (GO:0002446)2.72127101
842-oxoglutarate metabolic process (GO:0006103)2.70701013
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69707454
86positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.69322256
87regulation of necroptotic process (GO:0060544)2.69148008
88regulation of T-helper 2 cell differentiation (GO:0045628)2.68290450
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.67461398
90L-phenylalanine metabolic process (GO:0006558)2.67461398
91complement activation, alternative pathway (GO:0006957)2.67457463
92disruption of cells of other organism (GO:0044364)2.66663701
93killing of cells of other organism (GO:0031640)2.66663701
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65451269
95L-phenylalanine catabolic process (GO:0006559)2.64383197
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64383197
97necroptotic process (GO:0070266)2.64254325
98immunoglobulin mediated immune response (GO:0016064)2.63435978
99aromatic amino acid family catabolic process (GO:0009074)2.62968491
100negative regulation of interleukin-12 production (GO:0032695)2.62356176
101B cell receptor signaling pathway (GO:0050853)2.61893844
102triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.61102050
103regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.59974884
104negative regulation of interleukin-6 production (GO:0032715)2.59584662
105negative regulation of interleukin-17 production (GO:0032700)2.58744655
106sulfur amino acid catabolic process (GO:0000098)2.58698246
107negative regulation of toll-like receptor signaling pathway (GO:0034122)2.58269241
108positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.57013259
109regulation of platelet aggregation (GO:0090330)2.56437093
110positive regulation of leukocyte degranulation (GO:0043302)2.55584812
111kynurenine metabolic process (GO:0070189)2.55564004
112urea cycle (GO:0000050)2.53789402
113urea metabolic process (GO:0019627)2.53789402
114myeloid leukocyte activation (GO:0002274)2.53213786
115NADPH regeneration (GO:0006740)2.52676860
116neutrophil chemotaxis (GO:0030593)2.52390157
117cellular response to type I interferon (GO:0071357)2.52244060
118type I interferon signaling pathway (GO:0060337)2.52244060
119response to type I interferon (GO:0034340)2.52049603
120DNA unwinding involved in DNA replication (GO:0006268)2.51667723
121tricarboxylic acid metabolic process (GO:0072350)2.51455501
122embryonic process involved in female pregnancy (GO:0060136)2.50761972
123tryptophan catabolic process (GO:0006569)2.50735078
124indole-containing compound catabolic process (GO:0042436)2.50735078
125indolalkylamine catabolic process (GO:0046218)2.50735078
126glycine metabolic process (GO:0006544)2.50308194
127IMP metabolic process (GO:0046040)2.49327622
128response to fungus (GO:0009620)2.48087667
129positive regulation by symbiont of host defense response (GO:0052509)2.46248879
130modulation by symbiont of host defense response (GO:0052031)2.46248879
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46248879
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46248879
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.46248879
134modulation by symbiont of host immune response (GO:0052553)2.46248879
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.44962688
136amino-acid betaine metabolic process (GO:0006577)2.43971632
137negative regulation of granulocyte differentiation (GO:0030853)2.43820865
138oxaloacetate metabolic process (GO:0006107)2.42089747
139response to peptidoglycan (GO:0032494)2.41784755
140glyoxylate metabolic process (GO:0046487)2.40784635
141positive regulation of lamellipodium assembly (GO:0010592)2.40063717
142IMP biosynthetic process (GO:0006188)2.39621371
143regulation of triglyceride catabolic process (GO:0010896)2.39027971
144positive regulation of protein deacetylation (GO:0090312)2.38928483
145positive thymic T cell selection (GO:0045059)2.37272638
146regulation of protein activation cascade (GO:2000257)2.36644043
147B cell mediated immunity (GO:0019724)2.35071738
148JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.33810746
149mannose metabolic process (GO:0006013)2.33394047
150natural killer cell differentiation (GO:0001779)2.32661453
151regulation of cholesterol homeostasis (GO:2000188)2.31241878
152tryptophan metabolic process (GO:0006568)2.31003533
153glucose 6-phosphate metabolic process (GO:0051156)2.30502751
154positive regulation of triglyceride biosynthetic process (GO:0010867)2.29473527
155cellular extravasation (GO:0045123)2.29290779
156positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.29249613
157T cell homeostasis (GO:0043029)2.29134010
158folic acid-containing compound biosynthetic process (GO:0009396)2.29091405
159defense response to protozoan (GO:0042832)2.29012473
160leukocyte aggregation (GO:0070486)2.28239815
161regulation of complement activation (GO:0030449)2.26865684
162positive regulation of interferon-alpha production (GO:0032727)2.26419087
163regulation of interleukin-12 biosynthetic process (GO:0045075)2.25740183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20965133
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.78435829
3SCL_19346495_ChIP-Seq_HPC-7_Human3.12323674
4MYB_21317192_ChIP-Seq_ERMYB_Mouse2.95407820
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.93412564
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92696953
7MYC_22102868_ChIP-Seq_BL_Human2.83186748
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.82022309
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66284298
10GATA1_22025678_ChIP-Seq_K562_Human2.63414413
11VDR_21846776_ChIP-Seq_THP-1_Human2.61151011
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.57926593
13* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.49692966
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.42166552
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41689676
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.41428935
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35383755
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30816190
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26279513
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25904630
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25128907
22* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22764616
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14289049
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.11047576
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09516834
26TCF7_22412390_ChIP-Seq_EML_Mouse2.05824695
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94387317
28* SPI1_23547873_ChIP-Seq_NB4_Human1.88742323
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88441326
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.87344039
31VDR_24763502_ChIP-Seq_THP-1_Human1.84575099
32MAF_26560356_Chip-Seq_TH1_Human1.83926836
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83058160
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.82378549
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.79230490
36UTX_26944678_Chip-Seq_JUKART_Human1.69033130
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66496630
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65319999
39* MYB_26560356_Chip-Seq_TH1_Human1.63392596
40MYB_26560356_Chip-Seq_TH2_Human1.61889722
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.61189011
42VDR_24787735_ChIP-Seq_THP-1_Human1.58806700
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58773192
44* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.57818719
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57211172
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57154807
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53446482
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52767239
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52726514
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51578597
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50932615
52* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50849023
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48637428
54SPI1_23127762_ChIP-Seq_K562_Human1.45921817
55* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43105779
56* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40122715
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.39314036
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36468361
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36110422
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35515287
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.32791593
62* GATA2_21666600_ChIP-Seq_HMVEC_Human1.32728808
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32502532
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30342020
65CIITA_25753668_ChIP-Seq_RAJI_Human1.30206901
66RUNX_20019798_ChIP-Seq_JUKART_Human1.29966744
67* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29855937
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29535507
69KDM2B_26808549_Chip-Seq_DND41_Human1.28614814
70* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26490984
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24493111
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22139566
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21183125
74* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21069370
75* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20395411
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19670300
77PU_27001747_Chip-Seq_BMDM_Mouse1.18295993
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17949125
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.17847462
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17052453
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.15512857
82* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12597759
83NCOR1_26117541_ChIP-Seq_K562_Human1.12344106
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12280563
85* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11942092
86MAF_26560356_Chip-Seq_TH2_Human1.10690772
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09737212
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.09481322
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08502139
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.08188995
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06762139
92LXR_22292898_ChIP-Seq_THP-1_Human1.06268300
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05156764
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03802683
95GATA1_19941826_ChIP-Seq_K562_Human1.03184533
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03070058
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02655353
98GATA3_27048872_Chip-Seq_THYMUS_Human1.02600732
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02052231
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02019066
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98613855
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97512942
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97459824
104RACK7_27058665_Chip-Seq_MCF-7_Human0.96468226
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96439233
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94818592
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94660755
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94552859
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93740963
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92972972
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92925138
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92819602
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92496729
114RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91623138
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.91097552
116* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90974577
117TFEB_21752829_ChIP-Seq_HELA_Human0.90645410
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90310140
119* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89860077
120GATA2_19941826_ChIP-Seq_K562_Human0.88114738
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87988311
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86964582
123* CLOCK_20551151_ChIP-Seq_293T_Human0.86953973
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85183700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.09382389
2MP0002396_abnormal_hematopoietic_system2.96008077
3MP0002139_abnormal_hepatobiliary_system2.83416109
4MP0008260_abnormal_autophagy2.76346045
5MP0005360_urolithiasis2.71198221
6MP0003436_decreased_susceptibility_to2.64978805
7MP0005365_abnormal_bile_salt2.63922750
8MP0005464_abnormal_platelet_physiology2.59102696
9MP0001835_abnormal_antigen_presentation2.40687206
10MP0003303_peritoneal_inflammation2.38293243
11MP0009840_abnormal_foam_cell2.31402520
12MP0003828_pulmonary_edema2.29261659
13MP0005085_abnormal_gallbladder_physiolo2.26195296
14MP0005451_abnormal_body_composition2.24176078
15MP0005058_abnormal_lysosome_morphology2.16144279
16MP0001545_abnormal_hematopoietic_system2.07741310
17MP0005397_hematopoietic_system_phenotyp2.07741310
18MP0003300_gastrointestinal_ulcer1.98233496
19MP0002419_abnormal_innate_immunity1.96052585
20MP0008875_abnormal_xenobiotic_pharmacok1.95314719
21MP0003252_abnormal_bile_duct1.95231594
22MP0004808_abnormal_hematopoietic_stem1.90405404
23MP0000685_abnormal_immune_system1.84906808
24MP0001800_abnormal_humoral_immune1.84082203
25MP0010329_abnormal_lipoprotein_level1.80684059
26MP0005025_abnormal_response_to1.77033578
27MP0009278_abnormal_bone_marrow1.75653588
28MP0003172_abnormal_lysosome_physiology1.75472420
29MP0009785_altered_susceptibility_to1.71962953
30MP0002452_abnormal_antigen_presenting1.68010096
31MP0002877_abnormal_melanocyte_morpholog1.67896457
32MP0005000_abnormal_immune_tolerance1.64346424
33MP0001851_eye_inflammation1.63443420
34MP0002132_abnormal_respiratory_system1.63151568
35MP0005671_abnormal_response_to1.61854305
36* MP0002398_abnormal_bone_marrow1.60229873
37MP0003656_abnormal_erythrocyte_physiolo1.59725820
38* MP0002723_abnormal_immune_serum1.57500694
39* MP0002420_abnormal_adaptive_immunity1.56423623
40MP0000689_abnormal_spleen_morphology1.56241717
41* MP0001819_abnormal_immune_cell1.54410163
42MP0000609_abnormal_liver_physiology1.51651103
43MP0002166_altered_tumor_susceptibility1.50565213
44MP0003724_increased_susceptibility_to1.49960236
45MP0005174_abnormal_tail_pigmentation1.49315522
46MP0005387_immune_system_phenotype1.48332482
47MP0001790_abnormal_immune_system1.48332482
48MP0001853_heart_inflammation1.45780184
49MP0002722_abnormal_immune_system1.44575759
50MP0003806_abnormal_nucleotide_metabolis1.43926122
51MP0005075_abnormal_melanosome_morpholog1.43303902
52MP0008004_abnormal_stomach_pH1.42509406
53* MP0000716_abnormal_immune_system1.41896360
54MP0000465_gastrointestinal_hemorrhage1.41005221
55MP0001845_abnormal_inflammatory_respons1.40798535
56MP0010352_gastrointestinal_tract_polyps1.40568902
57MP0008469_abnormal_protein_level1.40002209
58MP0010155_abnormal_intestine_physiology1.37360113
59MP0004883_abnormal_blood_vessel1.35142311
60MP0005076_abnormal_cell_differentiation1.33780311
61MP0000490_abnormal_crypts_of1.33577761
62MP0003763_abnormal_thymus_physiology1.33112968
63* MP0002429_abnormal_blood_cell1.32888407
64MP0003183_abnormal_peptide_metabolism1.29838200
65MP0005319_abnormal_enzyme/_coenzyme1.29815253
66MP0002998_abnormal_bone_remodeling1.27802632
67MP0002405_respiratory_system_inflammati1.26706182
68MP0005164_abnormal_response_to1.24773201
69MP0004947_skin_inflammation1.23526046
70MP0005409_darkened_coat_color1.23149130
71MP0003705_abnormal_hypodermis_morpholog1.19981754
72MP0004147_increased_porphyrin_level1.19765773
73MP0004381_abnormal_hair_follicle1.19102237
74MP0000371_diluted_coat_color1.18983063
75MP0006082_CNS_inflammation1.18530913
76MP0001533_abnormal_skeleton_physiology1.17619994
77MP0003091_abnormal_cell_migration1.15837575
78* MP0000598_abnormal_liver_morphology1.14187788
79MP0002148_abnormal_hypersensitivity_rea1.13911809
80MP0001666_abnormal_nutrient_absorption1.12891405
81MP0004130_abnormal_muscle_cell1.12207835
82MP0003566_abnormal_cell_adhesion1.12032401
83MP0009333_abnormal_splenocyte_physiolog1.10045432
84MP0003866_abnormal_defecation1.07027516
85MP0005584_abnormal_enzyme/coenzyme_acti1.06417114
86* MP0009763_increased_sensitivity_to1.05319786
87MP0000703_abnormal_thymus_morphology1.04310406
88MP0002118_abnormal_lipid_homeostasis1.04207738
89MP0002006_tumorigenesis1.02124243
90MP0010307_abnormal_tumor_latency0.99703810
91MP0002009_preneoplasia0.99630823
92MP0001873_stomach_inflammation0.98871906
93MP0000015_abnormal_ear_pigmentation0.98001896
94MP0005083_abnormal_biliary_tract0.97862179
95MP0003075_altered_response_to0.97778251
96MP0006054_spinal_hemorrhage0.96548302
97MP0008961_abnormal_basal_metabolism0.94695846
98MP0005023_abnormal_wound_healing0.93260398
99MP0009643_abnormal_urine_homeostasis0.91507382
100MP0005332_abnormal_amino_acid0.91220615
101* MP0002019_abnormal_tumor_incidence0.89151163
102MP0003868_abnormal_feces_composition0.88297374
103MP0009764_decreased_sensitivity_to0.88285237
104MP0003448_altered_tumor_morphology0.87680247
105* MP0004264_abnormal_extraembryonic_tissu0.86799198
106MP0000858_altered_metastatic_potential0.86785581
107MP0005666_abnormal_adipose_tissue0.84775375
108MP0003186_abnormal_redox_activity0.84432321
109MP0004510_myositis0.83908856
110MP0001915_intracranial_hemorrhage0.83506597
111MP0002138_abnormal_hepatobiliary_system0.82828751
112MP0003690_abnormal_glial_cell0.82732607
113MP0004185_abnormal_adipocyte_glucose0.82524203
114MP0003453_abnormal_keratinocyte_physiol0.82517353
115MP0010094_abnormal_chromosome_stability0.81475018
116MP0008873_increased_physiological_sensi0.81420344
117MP0005166_decreased_susceptibility_to0.80804925
118MP0008057_abnormal_DNA_replication0.78732420
119* MP0000343_altered_response_to0.78269561
120MP0005390_skeleton_phenotype0.75275470
121MP0003943_abnormal_hepatobiliary_system0.74763588
122MP0001958_emphysema0.74624862
123MP0000569_abnormal_digit_pigmentation0.74318751
124MP0006036_abnormal_mitochondrial_physio0.74304802
125MP0000249_abnormal_blood_vessel0.73797833
126MP0003795_abnormal_bone_structure0.72239426
127MP0005310_abnormal_salivary_gland0.70296830
128MP0003045_fibrosis0.70082255
129* MP0005621_abnormal_cell_physiology0.67866501
130* MP0003221_abnormal_cardiomyocyte_apopto0.67098811
131MP0005375_adipose_tissue_phenotype0.65970716
132MP0000604_amyloidosis0.65509762
133MP0010234_abnormal_vibrissa_follicle0.64849726

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)3.91971497
2Recurrent bacterial skin infections (HP:0005406)3.75410321
3Recurrent abscess formation (HP:0002722)3.74526213
4Thrombocytosis (HP:0001894)3.51596804
5Gastrointestinal infarctions (HP:0005244)3.48159760
6Optic neuritis (HP:0100653)3.47890539
7Retrobulbar optic neuritis (HP:0100654)3.47890539
8Eczematoid dermatitis (HP:0000976)3.41390278
9Recurrent gram-negative bacterial infections (HP:0005420)3.38169920
10Gingivitis (HP:0000230)3.37572324
11IgM deficiency (HP:0002850)3.27465255
12Systemic lupus erythematosus (HP:0002725)3.15805354
13Peritonitis (HP:0002586)3.05698984
14Deep venous thrombosis (HP:0002625)3.05157650
15Epistaxis (HP:0000421)2.98046273
16Increased IgE level (HP:0003212)2.97069061
17Complement deficiency (HP:0004431)2.95772224
18Abnormal delayed hypersensitivity skin test (HP:0002963)2.92984938
19Recurrent viral infections (HP:0004429)2.92962282
20Colitis (HP:0002583)2.90853394
21Joint hemorrhage (HP:0005261)2.86085477
22Impaired platelet aggregation (HP:0003540)2.81633511
23Abnormal platelet function (HP:0011869)2.81633511
24Abnormality of the common coagulation pathway (HP:0010990)2.81100446
25Keratoconjunctivitis sicca (HP:0001097)2.77797286
26Spontaneous hematomas (HP:0007420)2.77490442
27Stomatitis (HP:0010280)2.76517048
28Gingival bleeding (HP:0000225)2.75756058
29Gastrointestinal inflammation (HP:0004386)2.74219730
30Abnormality of aromatic amino acid family metabolism (HP:0004338)2.73987581
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.73851693
32Inflammation of the large intestine (HP:0002037)2.73189892
33Hypoglycemic coma (HP:0001325)2.71148105
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70193106
35Abnormality of T cell physiology (HP:0011840)2.66745622
36Hypochromic anemia (HP:0001931)2.64798089
37Prolonged bleeding time (HP:0003010)2.64031723
38Petechiae (HP:0000967)2.63415755
39Polycythemia (HP:0001901)2.63250810
40Encephalitis (HP:0002383)2.63007831
41Vasculitis (HP:0002633)2.62916289
42Recurrent skin infections (HP:0001581)2.62639561
43Hypochromic microcytic anemia (HP:0004840)2.60637059
44Granulocytopenia (HP:0001913)2.59946984
45Recurrent fungal infections (HP:0002841)2.57870153
46Abnormality of T cell number (HP:0011839)2.51881228
47Xanthomatosis (HP:0000991)2.51720200
48Hypobetalipoproteinemia (HP:0003563)2.51460468
49Abnormality of complement system (HP:0005339)2.50104249
50Myositis (HP:0100614)2.46331078
51Elevated erythrocyte sedimentation rate (HP:0003565)2.46064611
52Panhypogammaglobulinemia (HP:0003139)2.45657699
53Keratoconjunctivitis (HP:0001096)2.44309090
54Chronic otitis media (HP:0000389)2.40955686
55Cellulitis (HP:0100658)2.40280494
56Abnormality of the thoracic spine (HP:0100711)2.39014401
57T lymphocytopenia (HP:0005403)2.38668797
58Intrahepatic cholestasis (HP:0001406)2.38325882
59Increased cerebral lipofuscin (HP:0011813)2.38313285
60Thoracic kyphosis (HP:0002942)2.36332380
61Abnormality of the peritoneum (HP:0002585)2.35495276
62Autoimmune thrombocytopenia (HP:0001973)2.35119676
63Agnosia (HP:0010524)2.34599432
64Prolonged partial thromboplastin time (HP:0003645)2.34376005
65Leukocytosis (HP:0001974)2.31989239
66Hyperlipoproteinemia (HP:0010980)2.30745032
67Dysostosis multiplex (HP:0000943)2.28867423
68Subacute progressive viral hepatitis (HP:0006572)2.28511018
69Autoimmune hemolytic anemia (HP:0001890)2.27132531
70Abnormal platelet volume (HP:0011876)2.26824998
71Viral hepatitis (HP:0006562)2.26659671
72Vacuolated lymphocytes (HP:0001922)2.26035968
73Abnormality of fatty-acid metabolism (HP:0004359)2.25437229
74Episodic fever (HP:0001954)2.24326444
75Mediastinal lymphadenopathy (HP:0100721)2.23324538
76Glomerulonephritis (HP:0000099)2.22959046
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.21168581
78Periodontitis (HP:0000704)2.20017664
79Meningitis (HP:0001287)2.19685318
80Ketosis (HP:0001946)2.18839257
81Abnormality of the intrinsic pathway (HP:0010989)2.16420130
82Abnormality of the fingertips (HP:0001211)2.15751322
83Urinary glycosaminoglycan excretion (HP:0003541)2.15194073
84Mucopolysacchariduria (HP:0008155)2.15194073
85Fatigue (HP:0012378)2.12552311
86Pulmonary infiltrates (HP:0002113)2.10091390
87Hemoptysis (HP:0002105)2.08959040
88Slow saccadic eye movements (HP:0000514)2.07738971
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07065408
90Menorrhagia (HP:0000132)2.05877992
91Generalized aminoaciduria (HP:0002909)2.05730582
92Hyperammonemia (HP:0001987)2.05613320
93Hematochezia (HP:0002573)2.05064960
94Abnormality of macrophages (HP:0004311)2.04189098
95Abnormality of T cells (HP:0002843)2.03673438
96Hypoplasia of the thymus (HP:0000778)2.01084723
97Eosinophilia (HP:0001880)2.00769217
98Interstitial pulmonary disease (HP:0006530)2.00564233
99Skin ulcer (HP:0200042)1.99460394
100Anorexia (HP:0002039)1.99032368
101Urticaria (HP:0001025)1.98783574
102Glomerulopathy (HP:0100820)1.95678005
103Increased mean platelet volume (HP:0011877)1.95675669
104Chest pain (HP:0100749)1.95214524
105Recurrent cutaneous fungal infections (HP:0011370)1.94550213
106Chronic mucocutaneous candidiasis (HP:0002728)1.94550213
107Abnormality of pyrimidine metabolism (HP:0004353)1.93841511
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93701903
109Abnormality of polysaccharide metabolism (HP:0011012)1.93701903
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93701903
111Obstructive lung disease (HP:0006536)1.93567826
112Chronic obstructive pulmonary disease (HP:0006510)1.93567826
113Purpura (HP:0000979)1.93048941
114Metaphyseal cupping (HP:0003021)1.92177365
115Spastic diplegia (HP:0001264)1.92164974
116Late onset (HP:0003584)1.90677825
117Increased IgM level (HP:0003496)1.90533136
118Thrombophlebitis (HP:0004418)1.86632985
119Increased connective tissue (HP:0009025)1.86444526
120Abnormality of iron homeostasis (HP:0011031)1.85486451
121Osteomyelitis (HP:0002754)1.85338935
122Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.84415708
123Dilatation of the ascending aorta (HP:0005111)1.83666901
124Myocardial infarction (HP:0001658)1.82830515
125Hypolipoproteinemia (HP:0010981)1.81053241
126Hypergammaglobulinemia (HP:0010702)1.80898869
127Increased serum ferritin (HP:0003281)1.80331575
128Hyperbilirubinemia (HP:0002904)1.80184997
129Sepsis (HP:0100806)1.79919048
130Ulnar deviation of the wrist (HP:0003049)1.79548828
131Acute myeloid leukemia (HP:0004808)1.79331779
132Pustule (HP:0200039)1.78996476
133Abnormality of the heme biosynthetic pathway (HP:0010472)1.78974186
134Difficulty running (HP:0009046)1.77957126
135Flat acetabular roof (HP:0003180)1.76924325
136Microcytic anemia (HP:0001935)1.76556892
137Spinal cord lesions (HP:0100561)1.75923264
138Syringomyelia (HP:0003396)1.75923264
139Aplastic anemia (HP:0001915)1.75829535
140Amyloidosis (HP:0011034)1.75038634
141Gangrene (HP:0100758)1.73798365
142Hypercholesterolemia (HP:0003124)1.72286066
143Arterial thrombosis (HP:0004420)1.71773936
144Hepatosplenomegaly (HP:0001433)1.70734354
145Pulmonary embolism (HP:0002204)1.70413555
146Acute hepatic failure (HP:0006554)1.70328982
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.70065196
148Osteolytic defects of the hand bones (HP:0009699)1.70065196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.62742545
2PKN23.46573516
3MAP4K13.37046136
4PRPF4B3.19475054
5TRIB33.12953208
6FLT32.77962499
7ERN12.58050771
8KIT2.27054174
9MAP3K102.20624430
10BTK2.11208298
11TGFBR22.06383283
12TAOK32.02078100
13STK102.01541085
14BCKDK1.90139374
15CSF1R1.80043826
16TYK21.73325461
17TEC1.64839531
18TBK11.58050616
19GRK61.56361775
20SCYL21.53998578
21RIPK41.50754117
22IRAK41.50179982
23KSR21.48585591
24TTN1.47311330
25CLK11.45617561
26IRAK31.40919486
27MAP3K21.39897491
28MAPKAPK31.38722461
29JAK31.37728143
30SMG11.36545721
31PTK61.36153905
32PAK41.31458987
33FGR1.31093972
34MATK1.29765813
35RPS6KB21.28396156
36YES11.26713077
37SYK1.25970910
38* MAP2K31.25915691
39FES1.24314621
40* ZAP701.20401089
41RIPK11.18614646
42BMPR21.17750918
43JAK21.14223656
44CDK121.13785026
45ITK1.12716991
46LRRK21.11778773
47BLK1.11624070
48CDC71.09814635
49RPS6KA41.09474956
50TAOK11.08061840
51NME21.05561365
52TGFBR11.04022536
53HCK1.03863220
54CDK41.02210738
55PIK3CG1.02010002
56FGFR41.00928745
57ICK0.99910671
58CAMK1D0.97650203
59IRAK10.97508979
60MARK20.96971745
61PDPK10.95453975
62CDK60.95136147
63NEK20.94903791
64CSK0.93307381
65PIM10.90201670
66TAOK20.88496050
67WEE10.86621472
68MAP3K70.84738856
69* LCK0.83100955
70JAK10.81514216
71SIK10.80446357
72MAP3K120.80383850
73IKBKB0.79415367
74SGK30.79220896
75LYN0.78406167
76IKBKE0.77081088
77RAF10.76913005
78MAP3K110.75065807
79EPHB10.74048388
80MAPK110.73130888
81MAP3K140.72005206
82IRAK20.71679795
83WNK10.70882011
84TXK0.69542168
85MARK30.69367885
86MAPK120.69103248
87STK380.68032915
88TRPM70.67962962
89MAP3K80.67682448
90* RET0.65968149
91MAPK40.65814420
92STK240.64994316
93STK40.64621065
94SIK30.63085774
95PDGFRB0.62317946
96PRKD20.59772336
97ALK0.59635171
98CAMK1G0.59389214
99TTK0.57990458
100KSR10.57817897
101PASK0.57657134
102EPHA30.56979244
103RPS6KC10.55981817
104RPS6KL10.55981817
105DAPK10.55863977
106PDK10.54887056
107KDR0.54471281
108SIK20.53106136
109MAPKAPK20.52679493
110MAPK70.51999889
111ATR0.50492313
112FGFR30.49981156
113CDC42BPA0.49402200
114CDK90.49011392
115HIPK20.48400626
116MAP3K130.48374336
117MAP3K10.47976520
118BMX0.47407869
119MAP3K30.47181738
120CDK70.47095174
121STK30.46375507
122NLK0.46368825
123PTK2B0.46030559
124DMPK0.45015632
125PIK3CA0.44472812
126BRD40.44108297
127NEK90.41052087
128EGFR0.40926364
129MAPKAPK50.40212426
130ACVR1B0.40107921
131TNK20.38947171
132RPS6KA20.38903364
133RPS6KA60.38567434
134CHUK0.38390097
135CAMKK10.35360997

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.85834574
2Staphylococcus aureus infection_Homo sapiens_hsa051502.74138333
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.46818776
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.41984997
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24575194
6Caffeine metabolism_Homo sapiens_hsa002322.09200283
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02594445
8Complement and coagulation cascades_Homo sapiens_hsa046101.93309707
9* Leishmaniasis_Homo sapiens_hsa051401.89977550
10DNA replication_Homo sapiens_hsa030301.89279383
11Arginine biosynthesis_Homo sapiens_hsa002201.87597198
12Malaria_Homo sapiens_hsa051441.76296384
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.66475813
14B cell receptor signaling pathway_Homo sapiens_hsa046621.65790168
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.59283275
16Fatty acid degradation_Homo sapiens_hsa000711.53671672
17* Osteoclast differentiation_Homo sapiens_hsa043801.49489842
18Starch and sucrose metabolism_Homo sapiens_hsa005001.49327219
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49236459
20Selenocompound metabolism_Homo sapiens_hsa004501.47904662
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47088030
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46653417
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44203754
24Lysine degradation_Homo sapiens_hsa003101.42539543
25ABC transporters_Homo sapiens_hsa020101.41643589
26One carbon pool by folate_Homo sapiens_hsa006701.41591199
27Renal cell carcinoma_Homo sapiens_hsa052111.38420919
28Other glycan degradation_Homo sapiens_hsa005111.36255592
29* T cell receptor signaling pathway_Homo sapiens_hsa046601.32906753
30Tryptophan metabolism_Homo sapiens_hsa003801.31734403
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29603448
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29252180
33Antigen processing and presentation_Homo sapiens_hsa046121.25896818
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.25789076
35Pentose phosphate pathway_Homo sapiens_hsa000301.24506092
36Biosynthesis of amino acids_Homo sapiens_hsa012301.24307798
37Peroxisome_Homo sapiens_hsa041461.23183980
38Acute myeloid leukemia_Homo sapiens_hsa052211.20926732
39* Hepatitis C_Homo sapiens_hsa051601.20260355
40Legionellosis_Homo sapiens_hsa051341.17730500
41Amoebiasis_Homo sapiens_hsa051461.14585521
42* VEGF signaling pathway_Homo sapiens_hsa043701.13866156
43* TNF signaling pathway_Homo sapiens_hsa046681.11807348
44Carbon metabolism_Homo sapiens_hsa012001.11766002
45Endometrial cancer_Homo sapiens_hsa052131.11653084
46Insulin resistance_Homo sapiens_hsa049311.10638549
47Primary immunodeficiency_Homo sapiens_hsa053401.10043614
48Mismatch repair_Homo sapiens_hsa034301.09056389
49Allograft rejection_Homo sapiens_hsa053301.08248691
50African trypanosomiasis_Homo sapiens_hsa051431.07115067
51* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07025070
52Graft-versus-host disease_Homo sapiens_hsa053321.04982803
53Chronic myeloid leukemia_Homo sapiens_hsa052201.04693468
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04352013
55* Platelet activation_Homo sapiens_hsa046111.03433503
56Phagosome_Homo sapiens_hsa041451.03378283
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02918551
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02427419
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02074496
60Galactose metabolism_Homo sapiens_hsa000521.00162398
61Autoimmune thyroid disease_Homo sapiens_hsa053200.99380438
62* Prolactin signaling pathway_Homo sapiens_hsa049170.98318648
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97801395
64Herpes simplex infection_Homo sapiens_hsa051680.97667043
65beta-Alanine metabolism_Homo sapiens_hsa004100.96997290
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94639874
67* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93865929
68* Pertussis_Homo sapiens_hsa051330.93738764
69Viral carcinogenesis_Homo sapiens_hsa052030.93466113
70PPAR signaling pathway_Homo sapiens_hsa033200.93299440
71Inositol phosphate metabolism_Homo sapiens_hsa005620.92926171
72* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90253222
73Lysosome_Homo sapiens_hsa041420.90115766
74Hematopoietic cell lineage_Homo sapiens_hsa046400.89961644
75Measles_Homo sapiens_hsa051620.89848156
76mTOR signaling pathway_Homo sapiens_hsa041500.89486103
77Viral myocarditis_Homo sapiens_hsa054160.89004376
78* FoxO signaling pathway_Homo sapiens_hsa040680.87694562
79Histidine metabolism_Homo sapiens_hsa003400.86856233
80* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86279455
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85655254
82Choline metabolism in cancer_Homo sapiens_hsa052310.84997196
83HIF-1 signaling pathway_Homo sapiens_hsa040660.84235869
84Glioma_Homo sapiens_hsa052140.83163509
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.83128605
86Prostate cancer_Homo sapiens_hsa052150.81463048
87Small cell lung cancer_Homo sapiens_hsa052220.81018480
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.80603085
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78804736
90Colorectal cancer_Homo sapiens_hsa052100.78330256
91Chemical carcinogenesis_Homo sapiens_hsa052040.77550920
92Endocytosis_Homo sapiens_hsa041440.76876677
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.76705043
94ErbB signaling pathway_Homo sapiens_hsa040120.76592747
95Fatty acid metabolism_Homo sapiens_hsa012120.75986118
96* Salmonella infection_Homo sapiens_hsa051320.75729259
97Propanoate metabolism_Homo sapiens_hsa006400.75061977
98* Sphingolipid signaling pathway_Homo sapiens_hsa040710.75035484
99N-Glycan biosynthesis_Homo sapiens_hsa005100.74899908
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74752908
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74121908
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72208375
103* Leukocyte transendothelial migration_Homo sapiens_hsa046700.71923689
104* Tuberculosis_Homo sapiens_hsa051520.71307202
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71276459
106Non-small cell lung cancer_Homo sapiens_hsa052230.70805141
107* Toxoplasmosis_Homo sapiens_hsa051450.69189024
108* GnRH signaling pathway_Homo sapiens_hsa049120.68692623
109Notch signaling pathway_Homo sapiens_hsa043300.67890694
110Hepatitis B_Homo sapiens_hsa051610.67428954
111* Influenza A_Homo sapiens_hsa051640.67281974
112Dorso-ventral axis formation_Homo sapiens_hsa043200.66844340
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.66598793
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66572029
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64975965
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.64881136
117* Shigellosis_Homo sapiens_hsa051310.64413080
118* Proteoglycans in cancer_Homo sapiens_hsa052050.64123407
119* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63618711
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63504063
121* Neurotrophin signaling pathway_Homo sapiens_hsa047220.62717882
122Bladder cancer_Homo sapiens_hsa052190.62560344
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61546313
124Base excision repair_Homo sapiens_hsa034100.61151260
125HTLV-I infection_Homo sapiens_hsa051660.60874153
126Apoptosis_Homo sapiens_hsa042100.59430639
127Bile secretion_Homo sapiens_hsa049760.58819135
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57133567
129Focal adhesion_Homo sapiens_hsa045100.56199481
130Type I diabetes mellitus_Homo sapiens_hsa049400.55387811
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55266780
132Thyroid cancer_Homo sapiens_hsa052160.54740827
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52546880
134Estrogen signaling pathway_Homo sapiens_hsa049150.52410990
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51344603
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.50978207
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50583405
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.50484803
139* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50206097
140Chemokine signaling pathway_Homo sapiens_hsa040620.47872682
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47094184
142Folate biosynthesis_Homo sapiens_hsa007900.46754378
143* NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45665003
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43440208
145Insulin signaling pathway_Homo sapiens_hsa049100.42909209
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42688727
147Pancreatic cancer_Homo sapiens_hsa052120.41908965
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41797293
149Glycerolipid metabolism_Homo sapiens_hsa005610.40408885

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