MAPK15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)8.11156049
2proline biosynthetic process (GO:0006561)7.83427571
3proline metabolic process (GO:0006560)6.49297370
4ventricular system development (GO:0021591)6.29187751
5microtubule bundle formation (GO:0001578)6.08600116
6primary alcohol catabolic process (GO:0034310)5.96335323
7left/right axis specification (GO:0070986)5.95527454
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.77182763
9L-phenylalanine catabolic process (GO:0006559)5.77182763
10L-phenylalanine metabolic process (GO:0006558)5.71506906
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.71506906
12Golgi transport vesicle coating (GO:0048200)5.41628704
13COPI coating of Golgi vesicle (GO:0048205)5.41628704
14lung epithelium development (GO:0060428)5.40411995
15vitamin transmembrane transport (GO:0035461)5.38746611
16cilium organization (GO:0044782)5.38202439
17cilium assembly (GO:0042384)5.26683853
18sperm capacitation (GO:0048240)5.23882211
19sulfur amino acid catabolic process (GO:0000098)5.01044415
20ethanol metabolic process (GO:0006067)4.95351577
21centriole assembly (GO:0098534)4.94392218
22COPII vesicle coating (GO:0048208)4.80695194
23diterpenoid biosynthetic process (GO:0016102)4.53535099
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.51648356
25glutamine family amino acid biosynthetic process (GO:0009084)4.48548629
26aromatic amino acid family catabolic process (GO:0009074)4.46108272
27protein retention in ER lumen (GO:0006621)4.36061729
28one-carbon compound transport (GO:0019755)4.35107538
29microtubule-based movement (GO:0007018)4.29917042
30glomerular epithelial cell development (GO:0072310)4.28376571
31endocrine pancreas development (GO:0031018)4.27180913
32establishment of apical/basal cell polarity (GO:0035089)4.25016283
33microtubule depolymerization (GO:0007019)4.22211547
34oxidative demethylation (GO:0070989)4.21144807
35negative regulation of T cell differentiation in thymus (GO:0033085)4.15105679
36regulation of cholesterol homeostasis (GO:2000188)4.14279959
37cellular component assembly involved in morphogenesis (GO:0010927)4.10128483
38protein localization to cilium (GO:0061512)4.08834273
39axonemal dynein complex assembly (GO:0070286)4.05428449
40intestinal cholesterol absorption (GO:0030299)4.04619452
41glyoxylate metabolic process (GO:0046487)4.03151516
42cilium morphogenesis (GO:0060271)3.87989522
43cell projection assembly (GO:0030031)3.84199830
44establishment of tissue polarity (GO:0007164)3.81258350
45establishment of planar polarity (GO:0001736)3.81258350
46microtubule polymerization or depolymerization (GO:0031109)3.80940317
47sperm motility (GO:0030317)3.80641040
48tolerance induction (GO:0002507)3.79450829
49L-alpha-amino acid transmembrane transport (GO:1902475)3.78842639
50regulation of interleukin-5 production (GO:0032674)3.78631794
51establishment or maintenance of monopolar cell polarity (GO:0061339)3.77191830
52establishment of monopolar cell polarity (GO:0061162)3.77191830
53transcription from mitochondrial promoter (GO:0006390)3.75181143
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73950724
55pyrimidine-containing compound transmembrane transport (GO:0072531)3.70823018
56triglyceride homeostasis (GO:0070328)3.69262583
57acylglycerol homeostasis (GO:0055090)3.69262583
58cellular zinc ion homeostasis (GO:0006882)3.61521495
59peptide hormone processing (GO:0016486)3.61086311
60response to xenobiotic stimulus (GO:0009410)3.60311447
61glutathione biosynthetic process (GO:0006750)3.60157002
62regulation of interleukin-13 production (GO:0032656)3.58788137
63cysteine metabolic process (GO:0006534)3.55407775
64cilium or flagellum-dependent cell motility (GO:0001539)3.53357441
65cytolysis (GO:0019835)3.49097327
66regulation of cilium movement (GO:0003352)3.48879088
67epithelial cilium movement (GO:0003351)3.45428452
68glutathione derivative metabolic process (GO:1901685)3.45114829
69glutathione derivative biosynthetic process (GO:1901687)3.45114829
70negative regulation of fatty acid biosynthetic process (GO:0045717)3.43463096
71ethanol oxidation (GO:0006069)3.42241484
72phosphatidylethanolamine biosynthetic process (GO:0006646)3.42241225
73tryptophan catabolic process (GO:0006569)3.42113748
74indole-containing compound catabolic process (GO:0042436)3.42113748
75indolalkylamine catabolic process (GO:0046218)3.42113748
76cilium movement (GO:0003341)3.41417064
77phosphatidylcholine biosynthetic process (GO:0006656)3.40326308
78tryptophan metabolic process (GO:0006568)3.39545943
79alkaloid metabolic process (GO:0009820)3.38949720
80planar cell polarity pathway involved in neural tube closure (GO:0090179)3.37134001
81nonribosomal peptide biosynthetic process (GO:0019184)3.36967700
82cytoplasmic microtubule organization (GO:0031122)3.36719442
83negative regulation of B cell mediated immunity (GO:0002713)3.33707271
84negative regulation of immunoglobulin mediated immune response (GO:0002890)3.33707271
85positive regulation of smoothened signaling pathway (GO:0045880)3.33587657
86kynurenine metabolic process (GO:0070189)3.33080168
87bile acid metabolic process (GO:0008206)3.30481312
88semaphorin-plexin signaling pathway (GO:0071526)3.29630262
89convergent extension (GO:0060026)3.29128155
90negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.28173853
91aromatic amino acid family metabolic process (GO:0009072)3.28041685
92retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28016507
93glandular epithelial cell development (GO:0002068)3.27537016
94bile acid biosynthetic process (GO:0006699)3.27454565
95tyrosine metabolic process (GO:0006570)3.27262911
96L-ascorbic acid metabolic process (GO:0019852)3.27169619
97complement activation, alternative pathway (GO:0006957)3.24678637
98negative regulation of inclusion body assembly (GO:0090084)3.23022877
99embryonic camera-type eye development (GO:0031076)3.22719074
100negative regulation of humoral immune response (GO:0002921)3.22131851
101embryonic process involved in female pregnancy (GO:0060136)3.20033014
102serine family amino acid catabolic process (GO:0009071)3.19325630
103glandular epithelial cell differentiation (GO:0002067)3.14296140
104alpha-linolenic acid metabolic process (GO:0036109)3.14232626
105macroautophagy (GO:0016236)3.13665920
106terpenoid biosynthetic process (GO:0016114)3.12703558
107nucleoside diphosphate phosphorylation (GO:0006165)3.12000183
108retinoic acid metabolic process (GO:0042573)3.11839442
109lateral ventricle development (GO:0021670)3.09789551
110phosphatidylethanolamine metabolic process (GO:0046337)3.08294542
111positive regulation of insulin secretion (GO:0032024)3.07250996
112regulation of microtubule-based movement (GO:0060632)3.07162698
113intraciliary transport (GO:0042073)3.06774857
114regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.06316955
115protein carboxylation (GO:0018214)3.05975947
116peptidyl-glutamic acid carboxylation (GO:0017187)3.05975947
117fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03199355
118very-low-density lipoprotein particle assembly (GO:0034379)3.01809744
119establishment or maintenance of bipolar cell polarity (GO:0061245)3.00718580
120establishment or maintenance of apical/basal cell polarity (GO:0035088)3.00718580
121triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.98203621
122positive regulation of protein homooligomerization (GO:0032464)2.98013470
123glycerol ether metabolic process (GO:0006662)2.96537292
124epithelial cell fate commitment (GO:0072148)2.96004635
125regulation of protein homooligomerization (GO:0032462)2.94463288
126ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.93889141
127urea metabolic process (GO:0019627)2.92984614
128urea cycle (GO:0000050)2.92984614
129regulation of protein activation cascade (GO:2000257)2.91446067
1304-hydroxyproline metabolic process (GO:0019471)2.90377757
131lateral sprouting from an epithelium (GO:0060601)2.90033818
132lysine catabolic process (GO:0006554)2.88687554
133lysine metabolic process (GO:0006553)2.88687554
134negative regulation of digestive system process (GO:0060457)2.88387217
135fatty acid beta-oxidation (GO:0006635)2.86737011
136multicellular organismal water homeostasis (GO:0050891)2.84803888
137cellular response to ATP (GO:0071318)2.83041553
138apical protein localization (GO:0045176)2.82951614
139regulation of microtubule depolymerization (GO:0031114)2.82583076
140O-glycan processing (GO:0016266)2.81633400
141positive regulation of glycolytic process (GO:0045821)2.81376498
142regulation of germinal center formation (GO:0002634)2.79886488
143microtubule severing (GO:0051013)2.79806417
144amino-acid betaine metabolic process (GO:0006577)2.79200505
145alpha-amino acid catabolic process (GO:1901606)2.78614983
146nitrogen cycle metabolic process (GO:0071941)2.78324482
147regulation of bile acid biosynthetic process (GO:0070857)2.78121795
148axoneme assembly (GO:0035082)2.77628147
149cellular amino acid catabolic process (GO:0009063)2.76086506
150drug transmembrane transport (GO:0006855)2.76054991
151negative regulation of fibrinolysis (GO:0051918)2.75665655
152regulation of complement activation (GO:0030449)2.74158305
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73990658
154positive regulation of peptide hormone secretion (GO:0090277)2.72882614
155sensory perception of taste (GO:0050909)2.72389770
156vesicle coating (GO:0006901)2.71598315
157genitalia morphogenesis (GO:0035112)2.70638999
158positive regulation of tolerance induction (GO:0002645)2.70330306
159regulation of fibrinolysis (GO:0051917)2.70045640
160ether metabolic process (GO:0018904)2.69357833
161high-density lipoprotein particle remodeling (GO:0034375)2.69181781
162microtubule-based process (GO:0007017)2.68915094
163asymmetric protein localization (GO:0008105)2.68607895
164fatty acid oxidation (GO:0019395)2.67467388
165cornea development in camera-type eye (GO:0061303)2.64898174
166negative regulation of JAK-STAT cascade (GO:0046426)2.64671680
167response to dietary excess (GO:0002021)2.64281505
168cellular ketone body metabolic process (GO:0046950)2.64257950
169indolalkylamine metabolic process (GO:0006586)2.62680306
170regulation of cilium assembly (GO:1902017)2.61854527
171glutathione metabolic process (GO:0006749)2.61340854
172GDP-mannose metabolic process (GO:0019673)2.60360233
173spermatid development (GO:0007286)2.58405034
174smoothened signaling pathway (GO:0007224)2.54432502
175retinol metabolic process (GO:0042572)2.52645695
176determination of left/right symmetry (GO:0007368)2.51424453
177calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.51098717
178excretion (GO:0007588)2.50857932
179primary alcohol metabolic process (GO:0034308)2.50657717
180exogenous drug catabolic process (GO:0042738)2.47580727
181regulation of smoothened signaling pathway (GO:0008589)2.45340029
182organelle assembly (GO:0070925)2.45209934
183sialylation (GO:0097503)2.43798826
184determination of bilateral symmetry (GO:0009855)2.42653061
185specification of symmetry (GO:0009799)2.37890564
186acrosome reaction (GO:0007340)2.36768438
187ear development (GO:0043583)2.35803879
188motile cilium assembly (GO:0044458)14.1569789

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.20557235
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.73022944
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.29477115
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.39472815
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.17358363
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.95244900
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.98557388
8DROSHA_22980978_ChIP-Seq_HELA_Human2.96805829
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.79152342
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.78417100
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67829444
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63434180
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.54320633
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.36544625
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26898776
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21337233
17* RUNX1_27514584_Chip-Seq_MCF-7_Human2.18764041
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14331431
19* LXR_22292898_ChIP-Seq_THP-1_Human2.11101761
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00499699
21BCL6_27268052_Chip-Seq_Bcells_Human1.80105030
22SA1_27219007_Chip-Seq_ERYTHROID_Human1.78993536
23VDR_21846776_ChIP-Seq_THP-1_Human1.76484456
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.74621225
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71235281
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69950658
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68954186
28* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.68761308
29* RARB_24833708_ChIP-Seq_LIVER_Mouse1.67647751
30CTCF_20526341_ChIP-Seq_ESCs_Human1.67137185
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66530896
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.64740000
33* TET1_21451524_ChIP-Seq_MESCs_Mouse1.64702357
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61048748
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59112236
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.57864313
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.57345336
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56545774
39TP53_22127205_ChIP-Seq_IMR90_Human1.54622943
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51044956
41* RARA_24833708_ChIP-Seq_LIVER_Mouse1.50100108
42CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45868487
43MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.44724283
44SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.44264836
45KLF5_25053715_ChIP-Seq_YYC3_Human1.44201634
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42830561
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42186158
48* EZH2_27294783_Chip-Seq_ESCs_Mouse1.38736517
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37834078
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36888920
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35676281
52TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.34596570
53* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.34255151
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32298583
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30896348
56ZNF263_19887448_ChIP-Seq_K562_Human1.30892562
57SPI1_26923725_Chip-Seq_HPCs_Mouse1.30672252
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30651647
59SA1_27219007_Chip-Seq_Bcells_Human1.30643032
60* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27282575
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27186203
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27069764
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26360668
64SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26050585
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23972555
66P300_27268052_Chip-Seq_Bcells_Human1.23461129
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.23211287
68ETS1_21867929_ChIP-Seq_TH2_Mouse1.22689732
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22186931
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21897051
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20700976
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19735094
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19038346
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19038346
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19038346
76CTCF_27219007_Chip-Seq_Bcells_Human1.18694343
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17953848
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17495607
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16759213
80* RACK7_27058665_Chip-Seq_MCF-7_Human1.16171757
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16045555
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.15722635
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15555087
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13296609
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13208187
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12104872
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11787169
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11183570
89TP53_23651856_ChIP-Seq_MEFs_Mouse1.10585278
90KDM2B_26808549_Chip-Seq_DND41_Human1.10475357
91ERA_21632823_ChIP-Seq_H3396_Human1.10339614
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.10171020
93* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09347719
94E2F1_20622854_ChIP-Seq_HELA_Human1.08351995
95* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08335447
96FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08295334
97PHF8_20622854_ChIP-Seq_HELA_Human1.07699757
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06383036
99OCT4_19829295_ChIP-Seq_ESCs_Human1.06351614
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05408824
101FOXA2_19822575_ChIP-Seq_HepG2_Human1.05392541
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05381962
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05363808
104CTCF_21964334_Chip-Seq_Bcells_Human1.05228344
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04992679
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04934406
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04788866
108P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03878289
109MAF_26560356_Chip-Seq_TH2_Human1.03231703
110TET1_21490601_ChIP-Seq_MESCs_Mouse1.02820069
111TCF7_22412390_ChIP-Seq_EML_Mouse1.01609152
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.01546414
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00906062
114BCOR_27268052_Chip-Seq_Bcells_Human1.00052980
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99546341
116* MYC_27129775_Chip-Seq_CORNEA_Mouse0.99094924
117TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98893850
118STAT1_20625510_ChIP-Seq_HELA_Human0.98729803
119EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98283105
120SMC4_20622854_ChIP-Seq_HELA_Human0.98055854
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.98015189
122SOX2_21211035_ChIP-Seq_LN229_Human0.97969886
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97530415
124GATA1_19941826_ChIP-Seq_K562_Human0.96190481
125SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96055884
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95459323
127FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95344496
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95108066
129OCT4_20526341_ChIP-Seq_ESCs_Human0.95083102
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93888897
131* CREB1_26743006_Chip-Seq_LNCaP_Human0.93394263
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93288125
133ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93098171
134AHR_22903824_ChIP-Seq_MCF-7_Human0.92740538
135NCOR1_26117541_ChIP-Seq_K562_Human0.92057995
136HNF4A_19822575_ChIP-Seq_HepG2_Human0.90181964
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.89118404
138NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88665368
139GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88629217
140FOXP1_21924763_ChIP-Seq_HESCs_Human0.88170482
141VDR_22108803_ChIP-Seq_LS180_Human0.87120519
142* TP63_22573176_ChIP-Seq_HFKS_Human0.87101623
143P68_20966046_ChIP-Seq_HELA_Human0.86534438
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86059382
145FLI1_21867929_ChIP-Seq_CD8_Mouse0.85783966
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83123809
147TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82748182
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.81867369
149KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81237264
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81096114
151KAP1_27257070_Chip-Seq_ESCs_Mouse0.81089209
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80877092
153PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79175647
154* RAC3_21632823_ChIP-Seq_H3396_Human0.79065601
155NANOG_16518401_ChIP-PET_MESCs_Mouse0.78550876
156KDM2B_26808549_Chip-Seq_K562_Human0.77936399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.42535134
2MP0005365_abnormal_bile_salt5.15332733
3MP0005085_abnormal_gallbladder_physiolo4.49413206
4MP0000566_synostosis4.14725178
5MP0005360_urolithiasis3.99532034
6MP0003195_calcinosis3.93033496
7MP0005377_hearing/vestibular/ear_phenot3.83013324
8MP0003878_abnormal_ear_physiology3.83013324
9MP0003283_abnormal_digestive_organ3.74653927
10MP0002132_abnormal_respiratory_system3.53697264
11MP0003252_abnormal_bile_duct2.88471148
12MP0008875_abnormal_xenobiotic_pharmacok2.79846834
13MP0003136_yellow_coat_color2.75715010
14MP0003806_abnormal_nucleotide_metabolis2.69355681
15MP0008789_abnormal_olfactory_epithelium2.65738745
16MP0002249_abnormal_larynx_morphology2.54754253
17MP0000013_abnormal_adipose_tissue2.51817350
18MP0005623_abnormal_meninges_morphology2.48645781
19MP0005220_abnormal_exocrine_pancreas2.43278016
20MP0002909_abnormal_adrenal_gland2.28388592
21MP0004019_abnormal_vitamin_homeostasis2.26644348
22MP0004043_abnormal_pH_regulation2.26615489
23MP0005409_darkened_coat_color2.22563997
24MP0002653_abnormal_ependyma_morphology2.21692470
25MP0002138_abnormal_hepatobiliary_system2.20365572
26MP0002877_abnormal_melanocyte_morpholog2.15377076
27MP0001944_abnormal_pancreas_morphology2.12870725
28MP0005379_endocrine/exocrine_gland_phen1.99720526
29MP0005332_abnormal_amino_acid1.96453360
30MP0005499_abnormal_olfactory_system1.95851881
31MP0005394_taste/olfaction_phenotype1.95851881
32MP0005645_abnormal_hypothalamus_physiol1.92722008
33MP0010329_abnormal_lipoprotein_level1.88103649
34MP0006072_abnormal_retinal_apoptosis1.86849463
35MP0000383_abnormal_hair_follicle1.85901760
36MP0002277_abnormal_respiratory_mucosa1.82502193
37MP0005083_abnormal_biliary_tract1.81903800
38MP0001666_abnormal_nutrient_absorption1.78165505
39MP0002928_abnormal_bile_duct1.77807281
40MP0002693_abnormal_pancreas_physiology1.75745215
41MP0001346_abnormal_lacrimal_gland1.71333559
42MP0004264_abnormal_extraembryonic_tissu1.69826221
43MP0001188_hyperpigmentation1.62158632
44MP0000751_myopathy1.61615273
45MP0002078_abnormal_glucose_homeostasis1.60876674
46MP0004233_abnormal_muscle_weight1.59291605
47MP0000003_abnormal_adipose_tissue1.57826533
48MP0005410_abnormal_fertilization1.57352256
49MP0000678_abnormal_parathyroid_gland1.57204475
50MP0009840_abnormal_foam_cell1.56535425
51MP0003868_abnormal_feces_composition1.55984188
52MP0000462_abnormal_digestive_system1.55351669
53MP0002118_abnormal_lipid_homeostasis1.54769316
54MP0003890_abnormal_embryonic-extraembry1.54433326
55MP0010234_abnormal_vibrissa_follicle1.53395966
56MP0005423_abnormal_somatic_nervous1.52759449
57MP0010678_abnormal_skin_adnexa1.51797707
58MP0003119_abnormal_digestive_system1.50830273
59MP0002160_abnormal_reproductive_system1.48139270
60MP0001849_ear_inflammation1.46247228
61MP0005058_abnormal_lysosome_morphology1.45731476
62MP0003183_abnormal_peptide_metabolism1.44366354
63MP0005174_abnormal_tail_pigmentation1.42756962
64MP0001764_abnormal_homeostasis1.42219218
65MP0009643_abnormal_urine_homeostasis1.41042832
66MP0003172_abnormal_lysosome_physiology1.40698553
67MP0005503_abnormal_tendon_morphology1.39383142
68MP0000609_abnormal_liver_physiology1.38794734
69MP0004133_heterotaxia1.37707865
70MP0000639_abnormal_adrenal_gland1.35881350
71MP0009278_abnormal_bone_marrow1.35561438
72MP0001986_abnormal_taste_sensitivity1.35286210
73MP0000026_abnormal_inner_ear1.18293509
74MP0005171_absent_coat_pigmentation1.17659890
75MP0009780_abnormal_chondrocyte_physiolo1.15421361
76MP0002837_dystrophic_cardiac_calcinosis1.14331971
77MP0008057_abnormal_DNA_replication1.11467028
78MP0003953_abnormal_hormone_level1.09805699
79MP0003705_abnormal_hypodermis_morpholog1.09562868
80MP0000467_abnormal_esophagus_morphology1.07472943
81MP0001756_abnormal_urination1.06815386
82MP0003656_abnormal_erythrocyte_physiolo1.04318961
83MP0005319_abnormal_enzyme/_coenzyme1.04166687
84MP0005636_abnormal_mineral_homeostasis1.03548898
85MP0004381_abnormal_hair_follicle1.01844808
86MP0010030_abnormal_orbit_morphology0.98068271
87MP0002735_abnormal_chemical_nociception0.97656176
88MP0002233_abnormal_nose_morphology0.96399265
89MP0008995_early_reproductive_senescence0.96238508
90MP0005670_abnormal_white_adipose0.96076991
91MP0001664_abnormal_digestion0.94937919
92MP0001765_abnormal_ion_homeostasis0.94779693
93MP0003959_abnormal_lean_body0.94770572
94MP0005076_abnormal_cell_differentiation0.94509872
95MP0008961_abnormal_basal_metabolism0.94271156
96MP0002098_abnormal_vibrissa_morphology0.92854335
97MP0002971_abnormal_brown_adipose0.92086469
98MP0005084_abnormal_gallbladder_morpholo0.91014873
99MP0001299_abnormal_eye_distance/0.90627804
100MP0001502_abnormal_circadian_rhythm0.90141707
101MP0008877_abnormal_DNA_methylation0.89150093
102MP0005375_adipose_tissue_phenotype0.87165891
103MP0002116_abnormal_craniofacial_bone0.85092209
104MP0005448_abnormal_energy_balance0.83245924
105MP0002269_muscular_atrophy0.82833469
106MP0000579_abnormal_nail_morphology0.81736523
107MP0002638_abnormal_pupillary_reflex0.81331273
108MP0002168_other_aberrant_phenotype0.80962673
109MP0002822_catalepsy0.80290050
110MP0003942_abnormal_urinary_system0.79800768
111MP0003191_abnormal_cellular_cholesterol0.79726296
112MP0000613_abnormal_salivary_gland0.79678441
113MP0005253_abnormal_eye_physiology0.78660206
114MP0002734_abnormal_mechanical_nocicepti0.76275501
115MP0009384_cardiac_valve_regurgitation0.76037622
116MP0005395_other_phenotype0.75877760
117MP0001324_abnormal_eye_pigmentation0.74980541
118MP0002111_abnormal_tail_morphology0.74490442
119MP0000371_diluted_coat_color0.74225685
120MP0000681_abnormal_thyroid_gland0.73383057
121MP0001270_distended_abdomen0.73159948
122MP0000598_abnormal_liver_morphology0.72153956
123MP0002282_abnormal_trachea_morphology0.71669496
124MP0002932_abnormal_joint_morphology0.70734760
125MP0002896_abnormal_bone_mineralization0.70490762
126MP0002009_preneoplasia0.70235211
127MP0009642_abnormal_blood_homeostasis0.68551552
128MP0005501_abnormal_skin_physiology0.67552293
129MP0010386_abnormal_urinary_bladder0.66407674
130MP0001293_anophthalmia0.66132075
131MP0001963_abnormal_hearing_physiology0.66004259
132MP0002136_abnormal_kidney_physiology0.65746290
133MP0002970_abnormal_white_adipose0.63955767
134MP0003937_abnormal_limbs/digits/tail_de0.62775286
135MP0003698_abnormal_male_reproductive0.62595171
136MP0000049_abnormal_middle_ear0.62493266
137MP0005266_abnormal_metabolism0.62466529
138MP0001929_abnormal_gametogenesis0.61339366
139MP0002161_abnormal_fertility/fecundity0.61303480
140MP0005535_abnormal_body_temperature0.60344257
141MP0010155_abnormal_intestine_physiology0.60194455
142MP0003861_abnormal_nervous_system0.59960432
143MP0002938_white_spotting0.59891348
144MP0001340_abnormal_eyelid_morphology0.57866461
145MP0000538_abnormal_urinary_bladder0.57532985
146MP0002796_impaired_skin_barrier0.56794396
147MP0003453_abnormal_keratinocyte_physiol0.56693384
148MP0005551_abnormal_eye_electrophysiolog0.56492348
149MP0005075_abnormal_melanosome_morpholog0.56352252
150MP0005334_abnormal_fat_pad0.55954997
151MP0006036_abnormal_mitochondrial_physio0.55652300
152MP0000470_abnormal_stomach_morphology0.55247560
153MP0001984_abnormal_olfaction0.54651057
154MP0002092_abnormal_eye_morphology0.54548075
155MP0005391_vision/eye_phenotype0.54498164
156MP0010771_integument_phenotype0.52312772
157MP0005248_abnormal_Harderian_gland0.51829153
158MP0005647_abnormal_sex_gland0.51715493
159MP0002060_abnormal_skin_morphology0.51559088
160MP0002115_abnormal_skeleton_extremities0.50590602
161MP0002084_abnormal_developmental_patter0.50352609
162MP0003091_abnormal_cell_migration0.50344822
163MP0000762_abnormal_tongue_morphology0.49895837

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)6.58776640
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.63960542
3Abnormality of the nasal mucosa (HP:0000433)5.46112894
4Hyperinsulinemic hypoglycemia (HP:0000825)5.22260448
5Hypoglycemic coma (HP:0001325)5.15103325
6Hypoglycemic seizures (HP:0002173)5.03383742
7Ketoacidosis (HP:0001993)4.86997402
8Pancreatic islet-cell hyperplasia (HP:0004510)4.36545495
9Symptomatic seizures (HP:0011145)4.16466572
10Ketosis (HP:0001946)4.08433287
11Abnormality of the pancreatic islet cells (HP:0006476)3.95989619
12Abnormality of endocrine pancreas physiology (HP:0012093)3.95989619
13Intrahepatic cholestasis (HP:0001406)3.93089692
14Mucopolysacchariduria (HP:0008155)3.90484158
15Urinary glycosaminoglycan excretion (HP:0003541)3.90484158
16Chronic bronchitis (HP:0004469)3.86147339
17Dysostosis multiplex (HP:0000943)3.75807026
18Bronchitis (HP:0012387)3.74220447
19Recurrent sinusitis (HP:0011108)3.72545271
20Large for gestational age (HP:0001520)3.72411984
21Occipital encephalocele (HP:0002085)3.70369752
22Turricephaly (HP:0000262)3.66547589
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.61003854
24Abnormality of polysaccharide metabolism (HP:0011012)3.61003854
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.61003854
26Atelectasis (HP:0100750)3.60793220
27Late onset (HP:0003584)3.59825723
28Recurrent otitis media (HP:0000403)3.54308415
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.47470546
30Chronic sinusitis (HP:0011109)3.44879450
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.41869670
32Hyperglycemia (HP:0003074)3.41458927
33Gout (HP:0001997)3.36210994
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.30280247
35Xanthomatosis (HP:0000991)3.21476126
36Abnormal respiratory epithelium morphology (HP:0012253)3.20262122
37Abnormal respiratory motile cilium morphology (HP:0005938)3.20262122
38Hypobetalipoproteinemia (HP:0003563)3.14898995
39Abnormal respiratory motile cilium physiology (HP:0012261)2.98505009
40Pancreatic fibrosis (HP:0100732)2.97527647
41Deep venous thrombosis (HP:0002625)2.95814601
42Dysautonomia (HP:0002459)2.94522571
43True hermaphroditism (HP:0010459)2.93781831
44Growth hormone excess (HP:0000845)2.91081333
45Prolonged partial thromboplastin time (HP:0003645)2.80203477
46Male infertility (HP:0003251)2.75349757
47Chronic hepatic failure (HP:0100626)2.74352265
48Complement deficiency (HP:0004431)2.72906586
49Bell-shaped thorax (HP:0001591)2.71003028
50Intestinal atresia (HP:0011100)2.69926558
51Retinal atrophy (HP:0001105)2.69349232
52Cystic liver disease (HP:0006706)2.69246745
53Nephronophthisis (HP:0000090)2.68445818
54Hyperactive renin-angiotensin system (HP:0000841)2.68233732
55Conjugated hyperbilirubinemia (HP:0002908)2.67744806
56Abnormal ciliary motility (HP:0012262)2.62409885
57Abnormality of midbrain morphology (HP:0002418)2.59595870
58Molar tooth sign on MRI (HP:0002419)2.59595870
59Rhinitis (HP:0012384)2.58719848
60Increased CSF protein (HP:0002922)2.57998062
61Hypochromic microcytic anemia (HP:0004840)2.55153227
62Insulin-resistant diabetes mellitus (HP:0000831)2.52972106
63Abnormality of the intrinsic pathway (HP:0010989)2.52834307
64Orthostatic hypotension (HP:0001278)2.50617325
65Menstrual irregularities (HP:0000858)2.37697128
66Chronic otitis media (HP:0000389)2.37567176
67Polycythemia (HP:0001901)2.34211353
68Abnormality of calcium-phosphate metabolism (HP:0100530)2.32737308
69Hyperglycinemia (HP:0002154)2.30945937
70Infertility (HP:0000789)2.29943512
71Insulin resistance (HP:0000855)2.28939298
72Hyperparathyroidism (HP:0000843)2.28921844
73Hypotension (HP:0002615)2.27943750
74Epidermoid cyst (HP:0200040)2.26845284
75Generalized aminoaciduria (HP:0002909)2.26640835
76Pancreatic cysts (HP:0001737)2.23623853
77Hyperammonemia (HP:0001987)2.23181127
78Anteriorly placed anus (HP:0001545)2.22866558
79Hyperglycinuria (HP:0003108)2.21266167
80Postaxial foot polydactyly (HP:0001830)2.20833646
81Exocrine pancreatic insufficiency (HP:0001738)2.20546623
82Abnormality of the common coagulation pathway (HP:0010990)2.19801570
83Fat malabsorption (HP:0002630)2.19188126
84Abnormal hemoglobin (HP:0011902)2.18385075
85Irritability (HP:0000737)2.16432224
86Hyperlipoproteinemia (HP:0010980)2.16206970
87Tubulointerstitial nephritis (HP:0001970)2.16173987
88Abnormality of purine metabolism (HP:0004352)2.15515596
89Agitation (HP:0000713)2.14516540
90Hypolipoproteinemia (HP:0010981)2.08403609
91Popliteal pterygium (HP:0009756)2.06866781
92Abnormality of the renal medulla (HP:0100957)2.05727130
93Bronchiectasis (HP:0002110)2.05288225
94Aplasia of the musculature (HP:0100854)2.04046769
95Alopecia of scalp (HP:0002293)2.02868963
96Alkalosis (HP:0001948)2.02675617
97Congenital hepatic fibrosis (HP:0002612)2.02452603
98Hypokalemia (HP:0002900)2.01939899
99Decreased circulating renin level (HP:0003351)2.01220406
100Increased IgM level (HP:0003496)1.99595965
101Abnormality of complement system (HP:0005339)1.99018992
102Abnormality of chloride homeostasis (HP:0011422)1.98855989
103Abnormal enzyme/coenzyme activity (HP:0012379)1.97083759
104Fetal akinesia sequence (HP:0001989)1.96673378
105Tubular atrophy (HP:0000092)1.96426235
106Rib fusion (HP:0000902)1.95485349
107Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94462967
108Hypercortisolism (HP:0001578)1.94092707
109Hypokalemic alkalosis (HP:0001949)1.94067411
110Osteomalacia (HP:0002749)1.93208337
111Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92910092
112Acute hepatic failure (HP:0006554)1.91877835
113Progressive neurologic deterioration (HP:0002344)1.91493621
114Abnormality of alkaline phosphatase activity (HP:0004379)1.91343278
115Enlarged kidneys (HP:0000105)1.90628300
116Dynein arm defect of respiratory motile cilia (HP:0012255)1.89689700
117Absent/shortened dynein arms (HP:0200106)1.89689700
118Abnormality of renin-angiotensin system (HP:0000847)1.89407381
119Abnormality of glycine metabolism (HP:0010895)1.87610136
120Abnormality of serine family amino acid metabolism (HP:0010894)1.87610136
121Asymmetric septal hypertrophy (HP:0001670)1.87346725
122Vaginal fistula (HP:0004320)1.84599973
123Unilateral renal agenesis (HP:0000122)1.84298694
124Abnormality of nucleobase metabolism (HP:0010932)1.83122435
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.82647753
126Skin nodule (HP:0200036)1.82447822
127Joint hemorrhage (HP:0005261)1.82378526
128Anencephaly (HP:0002323)1.79832183
129Ulnar bowing (HP:0003031)1.73087342
130Obstructive sleep apnea (HP:0002870)1.73021094
131Short thorax (HP:0010306)1.65730722
132Renal salt wasting (HP:0000127)1.64179047
133Male pseudohermaphroditism (HP:0000037)1.62866424
134Hand muscle atrophy (HP:0009130)1.61946969
135Decreased central vision (HP:0007663)1.59002253
136Hyperkalemia (HP:0002153)1.56861600
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.56668877
138Stridor (HP:0010307)1.55999360
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.55391451
140Absent frontal sinuses (HP:0002688)1.54344509
141Cervical subluxation (HP:0003308)1.54061281
142Dyschromatopsia (HP:0007641)1.53176584
143Flat acetabular roof (HP:0003180)1.51109541
144Nephropathy (HP:0000112)1.47707007
145Short nail (HP:0001799)1.46640376
146Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.45471511
147Sclerocornea (HP:0000647)1.43291532
148Short femoral neck (HP:0100864)1.43197582
149Stage 5 chronic kidney disease (HP:0003774)1.42692552
150Testicular atrophy (HP:0000029)1.42450408
151Recurrent bronchitis (HP:0002837)1.41832227
152Postaxial hand polydactyly (HP:0001162)1.41801107
153Medial flaring of the eyebrow (HP:0010747)1.41524709
154Absent epiphyses (HP:0010577)1.40580875
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40580875
156Distal upper limb amyotrophy (HP:0007149)1.38934577
157Upper limb amyotrophy (HP:0009129)1.38934577
158Thin bony cortex (HP:0002753)1.35877629
159Congenital primary aphakia (HP:0007707)1.33278012
160Oculomotor apraxia (HP:0000657)1.32911427
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.32786121
162Gait imbalance (HP:0002141)1.32574580
163Bony spicule pigmentary retinopathy (HP:0007737)1.30522721
164Abnormality of the distal phalanges of the toes (HP:0010182)1.30456074
165Asplenia (HP:0001746)1.30098704
166Renal dysplasia (HP:0000110)1.28732748
167Annular pancreas (HP:0001734)1.26926252
168Furrowed tongue (HP:0000221)1.26635215
169Hyponatremia (HP:0002902)1.26155287
170Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.24566865
171Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.23464104
172Median cleft lip (HP:0000161)1.22794596
173Preaxial hand polydactyly (HP:0001177)1.21883576
174Polydipsia (HP:0001959)1.21524086
175Abnormal drinking behavior (HP:0030082)1.21524086
176Hemorrhage of the eye (HP:0011885)1.19036029
177Lip pit (HP:0100267)1.18998146
178Abnormality of permanent molar morphology (HP:0011071)1.18656004
179Abnormality of the dental root (HP:0006486)1.18656004
180Taurodontia (HP:0000679)1.18656004
181Diaphragmatic weakness (HP:0009113)1.17030160
182Optic nerve coloboma (HP:0000588)1.12433029
183Nephrogenic diabetes insipidus (HP:0009806)1.12410142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.01688782
2INSRR4.14952445
3WNK33.94167264
4MST43.84041030
5DDR23.25785087
6NME13.17609347
7MST1R3.17021588
8DYRK1B3.04096989
9UHMK12.89132887
10PASK2.75198995
11PINK12.71972580
12EEF2K2.62116958
13SMG12.61204231
14WNK42.53339926
15MAP3K62.46899035
16MUSK2.27120796
17MAP3K112.24358569
18HIPK22.19147178
19PDGFRA2.19073543
20ERN12.14075137
21PIK3CG2.02607349
22TYRO32.02299703
23PRKD21.93763704
24DAPK11.92724851
25BCKDK1.80395310
26TLK11.60277617
27PRKD31.60026955
28FGFR41.58599584
29MAP3K71.57734413
30ERBB21.48160365
31MATK1.47272232
32SIK11.45325790
33PTK2B1.43995978
34MAP3K31.36963602
35NEK61.36788739
36TAOK31.36258436
37CDC42BPA1.35490620
38STK241.33541257
39PTK21.30636719
40PDK31.27752065
41PDK41.27752065
42GSK3A1.26931990
43EPHA21.25953131
44TTK1.25305912
45BMX1.21180622
46FLT31.20540826
47FGR1.19197277
48TRIB31.17794232
49LRRK21.16701200
50TESK11.14332101
51MAPK111.13498456
52DYRK31.13087694
53PKN21.11543986
54MAP3K101.11041166
55AKT31.10658485
56PNCK1.10018876
57MAP2K61.07303105
58RIPK11.06974692
59YES11.05530018
60TBK11.04115473
61RPS6KA21.03153090
62MAP3K21.00109838
63IRAK10.98831851
64MTOR0.98172362
65BCR0.97199954
66PDPK10.94951821
67FRK0.94499843
68PIM20.92866793
69PRKAA10.92249828
70CAMKK10.88741277
71PTK60.88004228
72SIK20.87244073
73PHKG10.86427170
74PHKG20.86427170
75CDK60.84976210
76GRK60.80708042
77NTRK10.77202807
78RPS6KC10.76365916
79RPS6KL10.76365916
80PAK30.75311552
81* MAPK150.72258663
82PAK40.71581207
83BLK0.70134568
84MET0.67180635
85MAP2K40.66609895
86* CSK0.66366441
87MAPKAPK30.65865061
88STK380.63406254
89RPS6KA60.63144044
90CDK70.62991541
91MAP3K10.62335866
92STK38L0.58615358
93MAP2K20.57985848
94LATS10.57608112
95EPHA30.57216909
96PRKCZ0.57194198
97RPS6KA10.55930968
98AURKA0.55895719
99STK160.55414101
100ROCK10.54841065
101NEK20.54545303
102ERBB30.53263345
103CAMK2B0.53088904
104CAMK2G0.51612267
105TAOK10.49853318
106MARK20.48845649
107NTRK30.48744376
108PRKCI0.47754105
109TRPM70.47634169
110CAMK2D0.47542476
111MAPK80.47365928
112ERBB40.47104820
113PDK20.45073364
114PRKCD0.43748075
115PRKACG0.43285528
116SGK10.43221315
117LMTK20.42283178
118PRKAA20.42228477
119ZAP700.42122868
120SGK4940.41337869
121SGK2230.41337869
122RPS6KB20.41061054
123TNK20.39899496
124JAK20.39633503
125STK100.39288372
126PDGFRB0.37805797
127AKT20.37482145
128FER0.37222354
129EGFR0.37209514
130RET0.36255988
131EPHB10.36148805
132SRC0.36135108
133SCYL20.35127450
134CDK120.34819892
135PIM10.34752515
136PLK10.33274434
137EPHB20.31735506
138MAPK30.31281943
139MAPK100.30694491
140WNK10.30018340
141LATS20.29969799
142PAK10.28633211
143RPS6KB10.28509033
144MAPK10.28162304
145CHUK0.28151438
146DAPK20.27531307
147PRKD10.27528664
148DYRK20.26947373
149STK110.25820283
150BRD40.24564075
151RPS6KA30.24457255
152ADRBK10.23634737
153MAPK140.23222406
154PRKACA0.22427417
155NTRK20.22392980
156CHEK20.22157829

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.41041884
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.13962192
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.81653925
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.62464588
5Tryptophan metabolism_Homo sapiens_hsa003802.57315745
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.38136137
7Selenocompound metabolism_Homo sapiens_hsa004502.33780149
8Butanoate metabolism_Homo sapiens_hsa006502.28226331
9Nitrogen metabolism_Homo sapiens_hsa009102.20643564
10Sulfur metabolism_Homo sapiens_hsa009202.20615168
11Arginine biosynthesis_Homo sapiens_hsa002202.12762703
12Sphingolipid metabolism_Homo sapiens_hsa006002.08636975
13Fatty acid biosynthesis_Homo sapiens_hsa000612.07662040
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07121556
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01288921
16Fatty acid metabolism_Homo sapiens_hsa012122.00479325
17Fatty acid degradation_Homo sapiens_hsa000711.98914499
18Folate biosynthesis_Homo sapiens_hsa007901.84146790
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.82393448
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76741490
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74837338
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71474221
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66757734
24Huntingtons disease_Homo sapiens_hsa050161.64113130
25Complement and coagulation cascades_Homo sapiens_hsa046101.59476640
26Histidine metabolism_Homo sapiens_hsa003401.59246594
27Peroxisome_Homo sapiens_hsa041461.58042201
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55849803
29Protein export_Homo sapiens_hsa030601.51283301
30Tight junction_Homo sapiens_hsa045301.51173415
31ABC transporters_Homo sapiens_hsa020101.49169623
32Propanoate metabolism_Homo sapiens_hsa006401.48056320
33Arginine and proline metabolism_Homo sapiens_hsa003301.45154226
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42396188
35Basal cell carcinoma_Homo sapiens_hsa052171.42236039
36Pyruvate metabolism_Homo sapiens_hsa006201.37649671
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35919599
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35095738
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34607502
40Insulin secretion_Homo sapiens_hsa049111.33590377
41Lysine degradation_Homo sapiens_hsa003101.32396095
42PPAR signaling pathway_Homo sapiens_hsa033201.25869309
43Bile secretion_Homo sapiens_hsa049761.25497594
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25396521
45Phenylalanine metabolism_Homo sapiens_hsa003601.23073478
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23011083
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22808089
48Starch and sucrose metabolism_Homo sapiens_hsa005001.22247191
49Circadian rhythm_Homo sapiens_hsa047101.21992398
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.21923494
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.19958130
52Sulfur relay system_Homo sapiens_hsa041221.18939695
53Fat digestion and absorption_Homo sapiens_hsa049751.17513314
54Taste transduction_Homo sapiens_hsa047421.14516957
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12679063
56Axon guidance_Homo sapiens_hsa043601.09878861
57beta-Alanine metabolism_Homo sapiens_hsa004101.08505863
58Biosynthesis of amino acids_Homo sapiens_hsa012301.07366562
59Glucagon signaling pathway_Homo sapiens_hsa049221.02245340
60Chemical carcinogenesis_Homo sapiens_hsa052041.02032561
61Tyrosine metabolism_Homo sapiens_hsa003501.01592619
62Hippo signaling pathway_Homo sapiens_hsa043901.00827626
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99144260
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98541450
65Fatty acid elongation_Homo sapiens_hsa000620.96308266
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90669589
67Prion diseases_Homo sapiens_hsa050200.90627894
68Retinol metabolism_Homo sapiens_hsa008300.87267607
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85668526
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85304798
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.83459824
72Choline metabolism in cancer_Homo sapiens_hsa052310.81199187
73Salivary secretion_Homo sapiens_hsa049700.79800963
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79184483
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.77220810
76Melanogenesis_Homo sapiens_hsa049160.76729670
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73979987
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.73266552
79Hepatitis C_Homo sapiens_hsa051600.71658571
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70607228
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68881175
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68596710
83Lysosome_Homo sapiens_hsa041420.68560402
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67188984
85Type II diabetes mellitus_Homo sapiens_hsa049300.63743893
86Fructose and mannose metabolism_Homo sapiens_hsa000510.62943078
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62806742
88Galactose metabolism_Homo sapiens_hsa000520.61877495
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60976457
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.60311451
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59376385
92Caffeine metabolism_Homo sapiens_hsa002320.59053668
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58723469
94N-Glycan biosynthesis_Homo sapiens_hsa005100.58471553
95Glycerolipid metabolism_Homo sapiens_hsa005610.58015257
96Carbon metabolism_Homo sapiens_hsa012000.56791137
97Linoleic acid metabolism_Homo sapiens_hsa005910.55440794
98Hedgehog signaling pathway_Homo sapiens_hsa043400.54974502
99Arachidonic acid metabolism_Homo sapiens_hsa005900.54687932
100Steroid biosynthesis_Homo sapiens_hsa001000.53892136
101Glutathione metabolism_Homo sapiens_hsa004800.52238719
102Adherens junction_Homo sapiens_hsa045200.51405528
103VEGF signaling pathway_Homo sapiens_hsa043700.48198727
104Ovarian steroidogenesis_Homo sapiens_hsa049130.46704705
105Phototransduction_Homo sapiens_hsa047440.46679304
106Inositol phosphate metabolism_Homo sapiens_hsa005620.46147803
107Endocytosis_Homo sapiens_hsa041440.45688141
108ECM-receptor interaction_Homo sapiens_hsa045120.45329016
109Nicotine addiction_Homo sapiens_hsa050330.44579861
110Other glycan degradation_Homo sapiens_hsa005110.44035009
111Staphylococcus aureus infection_Homo sapiens_hsa051500.43793766
112Olfactory transduction_Homo sapiens_hsa047400.43788214
113Insulin resistance_Homo sapiens_hsa049310.43281365
114Bladder cancer_Homo sapiens_hsa052190.42335460
115Thyroid hormone synthesis_Homo sapiens_hsa049180.41483901
116mTOR signaling pathway_Homo sapiens_hsa041500.40960491
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40950524
118Vibrio cholerae infection_Homo sapiens_hsa051100.40466595
119AMPK signaling pathway_Homo sapiens_hsa041520.39919782
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38929493
121Metabolic pathways_Homo sapiens_hsa011000.38918649
122Insulin signaling pathway_Homo sapiens_hsa049100.38619207
123Dorso-ventral axis formation_Homo sapiens_hsa043200.37931930
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37582182
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36312519
126cAMP signaling pathway_Homo sapiens_hsa040240.36034956
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35818829
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34630677
129Notch signaling pathway_Homo sapiens_hsa043300.34312288
130Wnt signaling pathway_Homo sapiens_hsa043100.34060595
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33326525
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32366629
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.31472339
134Calcium signaling pathway_Homo sapiens_hsa040200.31163473
135Cocaine addiction_Homo sapiens_hsa050300.31104023
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30370010
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.29896796
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24585813
139Regulation of autophagy_Homo sapiens_hsa041400.24097314
140Amphetamine addiction_Homo sapiens_hsa050310.24086023
141Collecting duct acid secretion_Homo sapiens_hsa049660.23313973
142Type I diabetes mellitus_Homo sapiens_hsa049400.22421543
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21786461
144Vitamin digestion and absorption_Homo sapiens_hsa049770.21388620
145Protein digestion and absorption_Homo sapiens_hsa049740.21365174
146Gap junction_Homo sapiens_hsa045400.20149973
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16121896

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