MAPK1IP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.21221587
2nuclear pore complex assembly (GO:0051292)5.17841211
3nuclear pore organization (GO:0006999)5.07483969
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.40937532
5replication fork processing (GO:0031297)4.18302165
6cullin deneddylation (GO:0010388)4.18284079
7proteasome assembly (GO:0043248)4.13011317
8pore complex assembly (GO:0046931)4.10900461
9DNA unwinding involved in DNA replication (GO:0006268)4.10679997
10protein localization to kinetochore (GO:0034501)4.04084565
11kinetochore organization (GO:0051383)4.01225770
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.93400768
13mitotic nuclear envelope disassembly (GO:0007077)3.88146993
14IMP biosynthetic process (GO:0006188)3.87616161
15mitotic metaphase plate congression (GO:0007080)3.78672603
16lactate metabolic process (GO:0006089)3.77827810
17protein deneddylation (GO:0000338)3.74054826
18DNA catabolic process, exonucleolytic (GO:0000738)3.60021964
19membrane disassembly (GO:0030397)3.58777362
20nuclear envelope disassembly (GO:0051081)3.58777362
21histone H2A acetylation (GO:0043968)3.55427098
22kinetochore assembly (GO:0051382)3.52747063
23protein localization to chromosome, centromeric region (GO:0071459)3.50936746
24mitotic sister chromatid cohesion (GO:0007064)3.49604454
25paraxial mesoderm development (GO:0048339)3.48841217
26maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.47781003
27RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.41225169
28metaphase plate congression (GO:0051310)3.40939740
29regulation of spindle organization (GO:0090224)3.39285232
30nucleobase biosynthetic process (GO:0046112)3.32729993
31respiratory chain complex IV assembly (GO:0008535)3.29719226
32DNA ligation (GO:0006266)3.27119791
33resolution of meiotic recombination intermediates (GO:0000712)3.26273296
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.25221110
35isotype switching (GO:0045190)3.25221110
36somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.25221110
37sister chromatid segregation (GO:0000819)3.25039405
38folic acid-containing compound biosynthetic process (GO:0009396)3.23198434
39IMP metabolic process (GO:0046040)3.22055500
40protein K6-linked ubiquitination (GO:0085020)3.21142413
41heterochromatin organization (GO:0070828)3.20412382
42establishment of chromosome localization (GO:0051303)3.20152536
43response to pheromone (GO:0019236)3.20090946
44purine nucleobase biosynthetic process (GO:0009113)3.18519635
45DNA replication initiation (GO:0006270)3.18317713
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16376594
47mitotic chromosome condensation (GO:0007076)3.16156518
48CENP-A containing nucleosome assembly (GO:0034080)3.15949151
49DNA replication checkpoint (GO:0000076)3.15580491
50DNA strand elongation involved in DNA replication (GO:0006271)3.15475895
51recombinational repair (GO:0000725)3.14217992
52chromatin remodeling at centromere (GO:0031055)3.13335593
53platelet dense granule organization (GO:0060155)3.12806108
54mitotic sister chromatid segregation (GO:0000070)3.12036336
55double-strand break repair via homologous recombination (GO:0000724)3.11150742
56pre-miRNA processing (GO:0031054)3.11025917
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09621120
58protein neddylation (GO:0045116)3.09359294
59dosage compensation (GO:0007549)3.08497772
60water-soluble vitamin biosynthetic process (GO:0042364)3.08483547
61DNA strand elongation (GO:0022616)3.05236647
62regulation of posttranscriptional gene silencing (GO:0060147)3.03284207
63regulation of gene silencing by miRNA (GO:0060964)3.03284207
64regulation of gene silencing by RNA (GO:0060966)3.03284207
65formation of translation preinitiation complex (GO:0001731)3.01170928
66meiotic chromosome segregation (GO:0045132)3.00487934
67double-strand break repair via nonhomologous end joining (GO:0006303)3.00300335
68non-recombinational repair (GO:0000726)3.00300335
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96390306
70DNA replication-independent nucleosome assembly (GO:0006336)2.95441722
71DNA replication-independent nucleosome organization (GO:0034724)2.95441722
72regulation of meiosis I (GO:0060631)2.94649824
73regulation of mitotic spindle organization (GO:0060236)2.93407315
74postreplication repair (GO:0006301)2.91423565
75DNA replication-dependent nucleosome assembly (GO:0006335)2.91320587
76DNA replication-dependent nucleosome organization (GO:0034723)2.91320587
77DNA duplex unwinding (GO:0032508)2.91127951
78branched-chain amino acid catabolic process (GO:0009083)2.90723804
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90358259
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90358259
81positive regulation of mitotic sister chromatid separation (GO:1901970)2.90358259
82DNA geometric change (GO:0032392)2.90332352
83mitotic recombination (GO:0006312)2.87905197
84negative regulation of DNA repair (GO:0045738)2.87326662
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86265485
86response to X-ray (GO:0010165)2.85922959
87attachment of spindle microtubules to kinetochore (GO:0008608)2.84742194
88negative regulation of DNA recombination (GO:0045910)2.84703252
89telomere maintenance via semi-conservative replication (GO:0032201)2.84394141
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84160233
91intraciliary transport (GO:0042073)2.84059831
92regulation of nuclear cell cycle DNA replication (GO:0033262)2.83964070
93histone mRNA metabolic process (GO:0008334)2.83447989
94synapsis (GO:0007129)2.81295028
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80552947
96regulation of translation, ncRNA-mediated (GO:0045974)2.78260620
97negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78260620
98negative regulation of translation, ncRNA-mediated (GO:0040033)2.78260620
99establishment of protein localization to mitochondrial membrane (GO:0090151)2.77427801
100telomere maintenance via recombination (GO:0000722)2.76679672
101DNA topological change (GO:0006265)2.76109602
102peptidyl-histidine modification (GO:0018202)2.73085875
103positive regulation of chromosome segregation (GO:0051984)2.72973973
104cytochrome complex assembly (GO:0017004)2.72627853
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71828591
106maturation of 5.8S rRNA (GO:0000460)2.71746611
107ribosome assembly (GO:0042255)2.68989410
108ATP-dependent chromatin remodeling (GO:0043044)2.68223292
109spindle checkpoint (GO:0031577)2.68122193
110mRNA transport (GO:0051028)2.67845252
111regulation of centrosome cycle (GO:0046605)2.67448000
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67299564
113ribosome biogenesis (GO:0042254)2.66541104
114regulation of centriole replication (GO:0046599)2.66539591
115regulation of double-strand break repair (GO:2000779)2.66535146
1163-UTR-mediated mRNA stabilization (GO:0070935)2.65428156
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65270193
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65270193
119protein K11-linked deubiquitination (GO:0035871)2.65166602
120regulation of mitotic metaphase/anaphase transition (GO:0030071)2.63878412
121protein prenylation (GO:0018342)2.63510876
122prenylation (GO:0097354)2.63510876
123protein localization to chromosome (GO:0034502)2.63034674
124ribosomal small subunit assembly (GO:0000028)2.62590598
125DNA strand renaturation (GO:0000733)2.62335627
126regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62124513
127regulation of mitotic spindle checkpoint (GO:1903504)2.62124513
128nuclear envelope organization (GO:0006998)2.61768586
129dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.61646672
130regulation of sister chromatid cohesion (GO:0007063)2.61187690
131regulation of DNA endoreduplication (GO:0032875)2.61100688
132presynaptic membrane assembly (GO:0097105)2.61068226
133chromosome segregation (GO:0007059)2.59219211
134somatic recombination of immunoglobulin gene segments (GO:0016447)2.58377251
135histone exchange (GO:0043486)2.57246799
136negative regulation of ligase activity (GO:0051352)2.56827288
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.56827288
138glucocorticoid receptor signaling pathway (GO:0042921)2.56567694
139regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56000514
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.55835543
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55835543
142regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.55174671
143negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55142589
144RNA stabilization (GO:0043489)2.54429638
145mRNA stabilization (GO:0048255)2.54429638
146somatic diversification of immunoglobulins (GO:0016445)2.53810338
147regulation of double-strand break repair via homologous recombination (GO:0010569)2.53446619
148chromatin assembly or disassembly (GO:0006333)2.53177543
149notochord development (GO:0030903)2.52112103
150negative regulation of chromosome segregation (GO:0051985)2.51928213
151regulation of helicase activity (GO:0051095)2.51892398
152spindle assembly checkpoint (GO:0071173)2.50880576
153ventricular cardiac muscle cell development (GO:0055015)2.50793951
154DNA conformation change (GO:0071103)2.50570913
155regulation of histone H3-K9 methylation (GO:0051570)2.50233219
156positive regulation of SMAD protein import into nucleus (GO:0060391)2.50140833
157mitotic spindle checkpoint (GO:0071174)2.50054618
158DNA deamination (GO:0045006)2.49788049
159negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.49445016
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.49334219
161negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49334219
162negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49334219
163negative regulation of sister chromatid segregation (GO:0033046)2.49334219
164snRNA processing (GO:0016180)2.49312010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.60198101
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.00476211
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.92464326
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.73358306
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47184033
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19580952
7ZNF274_21170338_ChIP-Seq_K562_Hela2.75217358
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64358861
9AR_21909140_ChIP-Seq_LNCAP_Human2.59658585
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55794031
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.50684178
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50163102
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48926058
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47865041
15EWS_26573619_Chip-Seq_HEK293_Human2.46355473
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42310450
17VDR_22108803_ChIP-Seq_LS180_Human2.41331408
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34304196
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33091683
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32580912
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.29692040
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.16718080
23FUS_26573619_Chip-Seq_HEK293_Human2.16384000
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.15291387
25* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13446431
26IGF1R_20145208_ChIP-Seq_DFB_Human2.09993801
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.09778470
28E2F7_22180533_ChIP-Seq_HELA_Human10.1960450
29P300_19829295_ChIP-Seq_ESCs_Human1.99023749
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97918396
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96132832
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95327179
33MYC_22102868_ChIP-Seq_BL_Human1.92797369
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92369614
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89520096
36GBX2_23144817_ChIP-Seq_PC3_Human1.88152586
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84623137
38TAF15_26573619_Chip-Seq_HEK293_Human1.84598873
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83667520
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80463881
41ELK1_19687146_ChIP-ChIP_HELA_Human1.80337526
42XRN2_22483619_ChIP-Seq_HELA_Human1.78119199
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74511341
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72871561
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72096604
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71286231
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68487104
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67942068
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64439958
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63960365
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63923131
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62666748
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58998894
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.54241461
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53682676
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53638025
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51356775
58* VDR_23849224_ChIP-Seq_CD4+_Human1.49450060
59TTF2_22483619_ChIP-Seq_HELA_Human1.48699158
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.48154498
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45814935
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.45327236
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44579847
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44579633
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41345978
66FOXP3_21729870_ChIP-Seq_TREG_Human1.40370574
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38986701
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38188684
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37409051
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35506900
71CIITA_25753668_ChIP-Seq_RAJI_Human1.35381862
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32475944
73DCP1A_22483619_ChIP-Seq_HELA_Human1.32451237
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31705182
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31090615
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30100887
77* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29522092
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28901514
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28056488
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27176736
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27002202
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.25930565
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25930256
84KDM5A_27292631_Chip-Seq_BREAST_Human1.25839575
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25032886
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24922272
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.24447924
88SMAD4_21799915_ChIP-Seq_A2780_Human1.23194123
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22827548
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22773445
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22158170
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21857328
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21723661
94ER_23166858_ChIP-Seq_MCF-7_Human1.21672308
95BCAT_22108803_ChIP-Seq_LS180_Human1.21023352
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.20431000
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.19147025
98* GABP_19822575_ChIP-Seq_HepG2_Human1.18653780
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.18437945
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17999641
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17999641
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17999641
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17186206
104TFEB_21752829_ChIP-Seq_HELA_Human1.16979842
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14820916
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14216207
107TCF4_22108803_ChIP-Seq_LS180_Human1.14048568
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13223424
109CBP_20019798_ChIP-Seq_JUKART_Human1.13223424
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.12544727
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11927787
112SOX2_19829295_ChIP-Seq_ESCs_Human1.11121225
113NANOG_19829295_ChIP-Seq_ESCs_Human1.11121225
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10615807
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10450359
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09641454
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08751560
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.08296219
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08269354
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08055565
121* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07325454
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06758188
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06722533
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06388272
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06039500
126AR_25329375_ChIP-Seq_VCAP_Human1.04879527
127* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04701303
128STAT3_23295773_ChIP-Seq_U87_Human1.04555473
129IRF1_19129219_ChIP-ChIP_H3396_Human1.03978866
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03232281
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02418882
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02172643
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01894665
134NANOG_21062744_ChIP-ChIP_HESCs_Human1.00858438
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00551412
136TP53_22573176_ChIP-Seq_HFKS_Human0.99628150
137* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99070341
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98762343
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98750682
140* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97950411
141TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97481423
142CHD1_26751641_Chip-Seq_LNCaP_Human0.97441711
143P53_22387025_ChIP-Seq_ESCs_Mouse0.97418225
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96560142
145FLI1_21867929_ChIP-Seq_TH2_Mouse0.95947565
146SOX2_16153702_ChIP-ChIP_HESCs_Human0.95365644
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94275885
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93667063
149THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93227103
150P300_18555785_Chip-Seq_ESCs_Mouse0.92197300
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.91839113
152OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91632121
153HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91064851
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.91056481
155SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90871538
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90668345
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89424146
158CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88593249
159SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87850723
160MYC_18940864_ChIP-ChIP_HL60_Human0.86445993
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86382014
162ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86346158
163ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85669818
164KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85046300
165ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83919418
166NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83252877
167SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82384907
168BRD4_25478319_ChIP-Seq_HGPS_Human0.78084184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.37736601
2MP0010094_abnormal_chromosome_stability3.06973493
3MP0002102_abnormal_ear_morphology2.89754663
4MP0008057_abnormal_DNA_replication2.85667956
5MP0003195_calcinosis2.84072746
6MP0004957_abnormal_blastocyst_morpholog2.83031454
7MP0003111_abnormal_nucleus_morphology2.82267998
8MP0003077_abnormal_cell_cycle2.71726851
9MP0010352_gastrointestinal_tract_polyps2.55622300
10MP0003123_paternal_imprinting2.37118363
11MP0008007_abnormal_cellular_replicative2.34697680
12MP0009053_abnormal_anal_canal2.33894374
13MP0006072_abnormal_retinal_apoptosis2.31050696
14MP0010030_abnormal_orbit_morphology2.28666259
15MP0000372_irregular_coat_pigmentation2.26203373
16MP0003705_abnormal_hypodermis_morpholog2.13386037
17MP0008058_abnormal_DNA_repair1.94483248
18MP0002736_abnormal_nociception_after1.89762981
19MP0003718_maternal_effect1.88620709
20MP0005076_abnormal_cell_differentiation1.85301100
21MP0000350_abnormal_cell_proliferation1.84866206
22MP0005253_abnormal_eye_physiology1.81602105
23MP0004197_abnormal_fetal_growth/weight/1.79678873
24MP0003121_genomic_imprinting1.79619660
25MP0001730_embryonic_growth_arrest1.79296920
26MP0002254_reproductive_system_inflammat1.78185230
27MP0001529_abnormal_vocalization1.78162165
28MP0010307_abnormal_tumor_latency1.74689465
29MP0000569_abnormal_digit_pigmentation1.73344629
30MP0001672_abnormal_embryogenesis/_devel1.71412997
31MP0005380_embryogenesis_phenotype1.71412997
32MP0008932_abnormal_embryonic_tissue1.71167573
33MP0003880_abnormal_central_pattern1.62121951
34MP0003984_embryonic_growth_retardation1.61601504
35MP0003567_abnormal_fetal_cardiomyocyte1.61394959
36MP0002088_abnormal_embryonic_growth/wei1.60371754
37MP0002751_abnormal_autonomic_nervous1.58242852
38MP0003890_abnormal_embryonic-extraembry1.55492652
39MP0004808_abnormal_hematopoietic_stem1.54708216
40MP0002086_abnormal_extraembryonic_tissu1.50177036
41MP0002396_abnormal_hematopoietic_system1.49632291
42MP0001697_abnormal_embryo_size1.49154981
43MP0001293_anophthalmia1.48315143
44MP0000516_abnormal_urinary_system1.48272367
45MP0005367_renal/urinary_system_phenotyp1.48272367
46MP0005551_abnormal_eye_electrophysiolog1.47594840
47MP0002084_abnormal_developmental_patter1.42699860
48MP0002085_abnormal_embryonic_tissue1.42249450
49MP0002090_abnormal_vision1.41790447
50MP0004215_abnormal_myocardial_fiber1.40693843
51MP0002837_dystrophic_cardiac_calcinosis1.40687386
52MP0003941_abnormal_skin_development1.34738658
53MP0000427_abnormal_hair_cycle1.33326175
54MP0005084_abnormal_gallbladder_morpholo1.31581322
55MP0000647_abnormal_sebaceous_gland1.30977940
56MP0003937_abnormal_limbs/digits/tail_de1.28818910
57MP0003119_abnormal_digestive_system1.28198962
58MP0000490_abnormal_crypts_of1.25560300
59MP0003787_abnormal_imprinting1.25387148
60MP0000537_abnormal_urethra_morphology1.25180258
61MP0001984_abnormal_olfaction1.23615316
62MP0000566_synostosis1.22759687
63MP0002080_prenatal_lethality1.19401595
64MP0006054_spinal_hemorrhage1.18624691
65MP0005023_abnormal_wound_healing1.17435613
66MP0002234_abnormal_pharynx_morphology1.16931918
67MP0003186_abnormal_redox_activity1.16720793
68MP0002111_abnormal_tail_morphology1.14605801
69MP0003566_abnormal_cell_adhesion1.14141815
70MP0003786_premature_aging1.13429825
71MP0005075_abnormal_melanosome_morpholog1.13285070
72MP0004133_heterotaxia1.11500676
73MP0003385_abnormal_body_wall1.11084081
74MP0009672_abnormal_birth_weight1.10839689
75MP0000631_abnormal_neuroendocrine_gland1.10625993
76MP0001915_intracranial_hemorrhage1.10565726
77MP0003942_abnormal_urinary_system1.09122070
78MP0005499_abnormal_olfactory_system1.08860681
79MP0005394_taste/olfaction_phenotype1.08860681
80MP0001968_abnormal_touch/_nociception1.08676224
81MP0000049_abnormal_middle_ear1.06976110
82MP0003115_abnormal_respiratory_system1.05967901
83MP0005646_abnormal_pituitary_gland1.05921933
84MP0000432_abnormal_head_morphology1.05532831
85MP0003755_abnormal_palate_morphology1.05461265
86MP0001929_abnormal_gametogenesis1.05166861
87MP0005248_abnormal_Harderian_gland1.03955157
88MP0002877_abnormal_melanocyte_morpholog1.03498537
89MP0008872_abnormal_physiological_respon1.02906541
90MP0005395_other_phenotype1.02457509
91MP0001286_abnormal_eye_development1.02177501
92MP0003136_yellow_coat_color1.01814754
93MP0000313_abnormal_cell_death1.01517377
94MP0005391_vision/eye_phenotype1.01171368
95MP0005503_abnormal_tendon_morphology1.00556791
96MP0003935_abnormal_craniofacial_develop0.98835009
97MP0002938_white_spotting0.97182339
98MP0000428_abnormal_craniofacial_morphol0.96954230
99MP0009703_decreased_birth_body0.96822122
100MP0002210_abnormal_sex_determination0.96578173
101MP0005645_abnormal_hypothalamus_physiol0.95813476
102MP0006035_abnormal_mitochondrial_morpho0.95637745
103MP0003315_abnormal_perineum_morphology0.94762254
104MP0002697_abnormal_eye_size0.94700501
105MP0000858_altered_metastatic_potential0.93487248
106MP0000733_abnormal_muscle_development0.93357268
107MP0000653_abnormal_sex_gland0.93261844
108MP0008877_abnormal_DNA_methylation0.92725866
109MP0003806_abnormal_nucleotide_metabolis0.91844552
110MP0002019_abnormal_tumor_incidence0.91448847
111MP0001324_abnormal_eye_pigmentation0.90847564
112MP0001177_atelectasis0.90669391
113MP0001119_abnormal_female_reproductive0.90258998
114MP0009250_abnormal_appendicular_skeleto0.90205958
115MP0003943_abnormal_hepatobiliary_system0.89792555
116MP0008789_abnormal_olfactory_epithelium0.89180106
117MP0001849_ear_inflammation0.88511283
118MP0002092_abnormal_eye_morphology0.88375719
119MP0002925_abnormal_cardiovascular_devel0.87742201
120MP0004264_abnormal_extraembryonic_tissu0.87365913
121MP0004147_increased_porphyrin_level0.86474466
122MP0006036_abnormal_mitochondrial_physio0.86363307
123MP0001485_abnormal_pinna_reflex0.86038533
124MP0002932_abnormal_joint_morphology0.85873657
125MP0001486_abnormal_startle_reflex0.85794018
126MP0001545_abnormal_hematopoietic_system0.85623278
127MP0005397_hematopoietic_system_phenotyp0.85623278
128MP0000383_abnormal_hair_follicle0.85303326
129MP0003122_maternal_imprinting0.85106766
130MP0001145_abnormal_male_reproductive0.84675269
131MP0005187_abnormal_penis_morphology0.84568791
132MP0009278_abnormal_bone_marrow0.84151082
133MP0006292_abnormal_olfactory_placode0.83172779
134MP0008438_abnormal_cutaneous_collagen0.83137406
135MP0005508_abnormal_skeleton_morphology0.82879076
136MP0009333_abnormal_splenocyte_physiolog0.82729774
137MP0010678_abnormal_skin_adnexa0.82709874
138MP0002282_abnormal_trachea_morphology0.82476624
139MP0002163_abnormal_gland_morphology0.82428633
140MP0005171_absent_coat_pigmentation0.81048680
141MP0001764_abnormal_homeostasis0.80879236
142MP0009046_muscle_twitch0.80840902
143MP0003011_delayed_dark_adaptation0.80705572
144MP0003279_aneurysm0.80509654
145MP0002109_abnormal_limb_morphology0.79385867
146MP0009697_abnormal_copulation0.78039491
147MP0003448_altered_tumor_morphology0.77805816
148MP0005408_hypopigmentation0.77317076
149MP0002095_abnormal_skin_pigmentation0.77219891
150MP0002233_abnormal_nose_morphology0.76825314
151MP0002638_abnormal_pupillary_reflex0.76141202
152MP0002160_abnormal_reproductive_system0.74921359
153MP0005195_abnormal_posterior_eye0.74255420
154MP0003137_abnormal_impulse_conducting0.74178220
155MP0000767_abnormal_smooth_muscle0.73435801
156MP0002116_abnormal_craniofacial_bone0.73412294
157MP0005174_abnormal_tail_pigmentation0.72967047
158MP0008775_abnormal_heart_ventricle0.72809407
159MP0005379_endocrine/exocrine_gland_phen0.72585973
160MP0002249_abnormal_larynx_morphology0.71190705
161MP0002113_abnormal_skeleton_development0.70444152
162MP0001175_abnormal_lung_morphology0.68429489

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)3.39912260
2Abnormality of the anterior horn cell (HP:0006802)3.39912260
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.29483685
4Short 4th metacarpal (HP:0010044)3.29483685
5Pancreatic cysts (HP:0001737)3.20244259
6Spinal cord lesions (HP:0100561)3.11099845
7Syringomyelia (HP:0003396)3.11099845
8Intestinal atresia (HP:0011100)3.03719037
9True hermaphroditism (HP:0010459)3.03095243
10Methylmalonic acidemia (HP:0002912)2.88390619
11Pancreatic fibrosis (HP:0100732)2.87011637
12Birth length less than 3rd percentile (HP:0003561)2.78483790
13Molar tooth sign on MRI (HP:0002419)2.77291180
14Abnormality of midbrain morphology (HP:0002418)2.77291180
15Chromsome breakage (HP:0040012)2.70447282
16Ectopic kidney (HP:0000086)2.64155083
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56662666
18Colon cancer (HP:0003003)2.54025844
19Abnormality of the preputium (HP:0100587)2.53026445
20Medial flaring of the eyebrow (HP:0010747)2.50788990
21Patellar aplasia (HP:0006443)2.50327229
22Deviation of the thumb (HP:0009603)2.48176070
23Selective tooth agenesis (HP:0001592)2.44646283
24Aplasia/Hypoplasia of the patella (HP:0006498)2.41356835
25Breast hypoplasia (HP:0003187)2.31356372
26Abnormality of the 4th metacarpal (HP:0010012)2.31154888
27Nephronophthisis (HP:0000090)2.29591089
28Aplasia/Hypoplasia of the tongue (HP:0010295)2.29375813
29Impulsivity (HP:0100710)2.26731356
30Pancreatic islet-cell hyperplasia (HP:0004510)2.26303731
31Sloping forehead (HP:0000340)2.21345656
32Medulloblastoma (HP:0002885)2.20523658
33Hypothermia (HP:0002045)2.20158778
34Methylmalonic aciduria (HP:0012120)2.14980314
35Abnormal lung lobation (HP:0002101)2.14294769
36Proximal placement of thumb (HP:0009623)2.14252813
37Broad thumb (HP:0011304)2.14052850
38Abnormality of the nasal septum (HP:0000419)2.13239790
39Progressive macrocephaly (HP:0004481)2.12116941
40Glioma (HP:0009733)2.11901141
41Deep philtrum (HP:0002002)2.11869283
42Abnormality of methionine metabolism (HP:0010901)2.11861647
43Congenital primary aphakia (HP:0007707)2.11660223
44Nephroblastoma (Wilms tumor) (HP:0002667)2.10540035
45Bifid tongue (HP:0010297)2.09593893
46Long eyelashes (HP:0000527)2.09360256
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08844819
48Asymmetry of the thorax (HP:0001555)2.08537802
49Genital tract atresia (HP:0001827)2.08430597
50Astrocytoma (HP:0009592)2.07133673
51Abnormality of the astrocytes (HP:0100707)2.07133673
52Preaxial hand polydactyly (HP:0001177)2.06012320
53Aqueductal stenosis (HP:0002410)2.04850249
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.04829622
55Abnormal number of incisors (HP:0011064)2.04504595
56Embryonal renal neoplasm (HP:0011794)2.04102673
57Hyperglycinemia (HP:0002154)2.02941824
58Acute necrotizing encephalopathy (HP:0006965)2.02837788
59Acute encephalopathy (HP:0006846)2.02720064
60Clubbing of toes (HP:0100760)2.01603944
61Hypoproteinemia (HP:0003075)2.01104967
62Abnormality of the renal medulla (HP:0100957)2.00666372
63Gait imbalance (HP:0002141)1.99593956
64Abnormality of the distal phalanx of the thumb (HP:0009617)1.99193651
65Vaginal atresia (HP:0000148)1.97056034
66Abnormality of the fingertips (HP:0001211)1.96923656
67Nephrogenic diabetes insipidus (HP:0009806)1.96625518
68Mesomelia (HP:0003027)1.96181973
69Meckel diverticulum (HP:0002245)1.95769775
70Abnormality of vitamin B metabolism (HP:0004340)1.95490828
71Abnormality of the labia minora (HP:0012880)1.95173801
72Sclerocornea (HP:0000647)1.94684945
73Gastrointestinal atresia (HP:0002589)1.93767609
74Atresia of the external auditory canal (HP:0000413)1.92937277
75Rib fusion (HP:0000902)1.92627191
7611 pairs of ribs (HP:0000878)1.91351473
77Hyperinsulinemic hypoglycemia (HP:0000825)1.91046313
78Long clavicles (HP:0000890)1.90852683
79Increased CSF lactate (HP:0002490)1.90581063
80Dandy-Walker malformation (HP:0001305)1.89653536
81Type I transferrin isoform profile (HP:0003642)1.88845672
82Pendular nystagmus (HP:0012043)1.88051647
83Short 5th finger (HP:0009237)1.87630938
84Abnormality of the intervertebral disk (HP:0005108)1.86970315
85Abnormality of the metopic suture (HP:0005556)1.86473167
86Oligodactyly (hands) (HP:0001180)1.86417997
87Thyroiditis (HP:0100646)1.85879819
88Adrenal hypoplasia (HP:0000835)1.85205570
89Neoplasm of the adrenal gland (HP:0100631)1.85198295
90Short middle phalanx of the 5th finger (HP:0004220)1.84616456
91Abnormality of the renal cortex (HP:0011035)1.84589467
92Shallow orbits (HP:0000586)1.83864321
93Postaxial foot polydactyly (HP:0001830)1.83794063
94Chronic hepatic failure (HP:0100626)1.83215285
95Broad phalanges of the hand (HP:0009768)1.83052121
96Short 1st metacarpal (HP:0010034)1.81873347
97Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81873347
98Abnormality of chromosome stability (HP:0003220)1.81835707
99Abnormality of the pons (HP:0007361)1.81761317
100Abnormality of the vitamin B12 metabolism (HP:0004341)1.81558670
101Rhabdomyosarcoma (HP:0002859)1.81376059
102Rectal prolapse (HP:0002035)1.81353307
103Protrusio acetabuli (HP:0003179)1.81165086
104Volvulus (HP:0002580)1.81116992
105Postaxial hand polydactyly (HP:0001162)1.81086684
106Increased nuchal translucency (HP:0010880)1.80711929
107Abnormality of the ileum (HP:0001549)1.79775162
108Astigmatism (HP:0000483)1.78588185
109Hepatoblastoma (HP:0002884)1.78216713
110Hyperventilation (HP:0002883)1.78090474
111Gastrointestinal carcinoma (HP:0002672)1.77837142
112Malignant gastrointestinal tract tumors (HP:0006749)1.77837142
113Abnormality of the phalanges of the hallux (HP:0010057)1.75867223
114Hypoplastic pelvis (HP:0008839)1.75684507
115Neoplasm of the adrenal cortex (HP:0100641)1.75540999
116Abnormality of glycine metabolism (HP:0010895)1.75526263
117Abnormality of serine family amino acid metabolism (HP:0010894)1.75526263
118Progressive inability to walk (HP:0002505)1.75377682
119Abnormality of serum amino acid levels (HP:0003112)1.75154288
120Hypoglycemic seizures (HP:0002173)1.75027217
121Shawl scrotum (HP:0000049)1.75024378
122Agnosia (HP:0010524)1.74766350
123Facial hemangioma (HP:0000329)1.74748160
124Carpal bone hypoplasia (HP:0001498)1.74324159
125Small hand (HP:0200055)1.73711671
126Irregular epiphyses (HP:0010582)1.73539176
127Missing ribs (HP:0000921)1.73490499
128Anencephaly (HP:0002323)1.73264113
129Renal hypoplasia (HP:0000089)1.71889195
130Hypoplasia of the fovea (HP:0007750)1.70465501
131Aplasia/Hypoplasia of the fovea (HP:0008060)1.70465501
132Aplasia/hypoplasia of the humerus (HP:0006507)1.70090473
133Abnormality of the calcaneus (HP:0008364)1.70085908
134Optic nerve coloboma (HP:0000588)1.69692108
135Supernumerary spleens (HP:0009799)1.69530713
136Broad palm (HP:0001169)1.69460133
137Triphalangeal thumb (HP:0001199)1.69308130
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68675327
139Abnormal protein N-linked glycosylation (HP:0012347)1.68675327
140Abnormal protein glycosylation (HP:0012346)1.68675327
141Abnormal glycosylation (HP:0012345)1.68675327
142Abnormality of glycolysis (HP:0004366)1.68058871
143Absent radius (HP:0003974)1.68019066
144Duodenal stenosis (HP:0100867)1.67753728
145Small intestinal stenosis (HP:0012848)1.67753728
146Increased density of long bones (HP:0006392)1.67063332
147Aplasia involving forearm bones (HP:0009822)1.67003184
148Absent forearm bone (HP:0003953)1.67003184
149Ependymoma (HP:0002888)1.66792869
150Short humerus (HP:0005792)1.66400877
151Broad finger (HP:0001500)1.66187024
152Abolished electroretinogram (ERG) (HP:0000550)1.66013845
153Prominent metopic ridge (HP:0005487)1.65955117
154Broad phalanx (HP:0006009)1.65133592
155Biliary tract neoplasm (HP:0100574)1.65043359
156Abnormal hair whorl (HP:0010721)1.64836352
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.64247181
158Male pseudohermaphroditism (HP:0000037)1.64120261
159Congenital stationary night blindness (HP:0007642)1.64025329
160Myelodysplasia (HP:0002863)1.63501372
161Trigonocephaly (HP:0000243)1.63142344
162Uterine neoplasm (HP:0010784)1.62315568
163Skull defect (HP:0001362)1.62040356
164Abnormality of the incisor (HP:0000676)1.61872411
165Diastasis recti (HP:0001540)1.61808802
166Subacute progressive viral hepatitis (HP:0006572)1.61782814
167Absent frontal sinuses (HP:0002688)1.61365445
168Vitreoretinal degeneration (HP:0000655)1.60684317
169Increased number of teeth (HP:0011069)1.60389862
170Metaphyseal cupping (HP:0003021)1.59259157
171Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.59159684
172Broad long bones (HP:0005622)1.58805365
173Intestinal fistula (HP:0100819)1.58698242
174Acute myeloid leukemia (HP:0004808)1.57646562
175Short thumb (HP:0009778)1.55894673
176Cutaneous melanoma (HP:0012056)1.55230402
177Neoplasm of the pancreas (HP:0002894)1.55227836
178Cutis marmorata (HP:0000965)1.54467703
179Abnormality of the 1st metacarpal (HP:0010009)1.53462090
180Abnormality of the duodenum (HP:0002246)1.51290509
181Abnormal biliary tract morphology (HP:0012440)1.51153316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.67584497
2TRIM283.49140550
3MKNK13.11312636
4CDK123.10491277
5WNK32.93537987
6SRPK12.44913680
7TNIK2.41985293
8BMPR1B2.36537972
9WEE12.33706641
10MAP4K22.28782931
11PLK42.25582390
12MKNK22.23117263
13LATS12.17518761
14BRSK22.16935954
15RPS6KA42.06156392
16BRD42.01634745
17NEK21.97618130
18BUB11.96993317
19EIF2AK11.92647128
20STK38L1.80551903
21PLK31.73279965
22MAP3K101.61107623
23STK101.58058306
24STK31.57860980
25PASK1.56203340
26TTK1.55724167
27ERBB31.54668870
28TGFBR11.53782944
29ZAK1.53179166
30CDK71.52618900
31TSSK61.52166239
32BCR1.50024590
33PLK11.45096918
34ATR1.42414491
35CASK1.41931726
36GRK11.38345180
37VRK21.36066371
38CDK41.33615392
39PNCK1.33387373
40RPS6KB21.32549624
41ACVR1B1.31857385
42PIM11.31641368
43CDK61.30691044
44AURKB1.28890692
45STK41.28339213
46INSRR1.27079367
47EPHA21.25868156
48CHEK11.13547056
49CSNK1G11.13263221
50FRK1.12953356
51EIF2AK21.12569252
52STK391.11584555
53CHUK1.11376660
54NEK91.09010430
55MAP3K81.08490743
56CHEK21.08188371
57LATS21.07257780
58TAF11.06954032
59MAP3K141.06780916
60NEK11.03962101
61ADRBK21.00937768
62EEF2K1.00918798
63NUAK11.00774364
64BRSK11.00695182
65MAPK131.00546318
66SIK30.99685288
67PAK40.95031223
68MELK0.94708068
69PIM20.94371664
70CSNK1G30.92073310
71STK240.91022684
72PKN20.90367726
73CSNK1G20.90139422
74ATM0.89937501
75FGFR20.88693052
76FGFR30.87862373
77AKT30.87798404
78EIF2AK30.85995080
79STK160.83691600
80MAP3K40.82327290
81FLT30.81048024
82TAOK20.80919219
83PAK30.80537807
84CSNK1A1L0.79970492
85CDK20.79552369
86JAK30.79417711
87OXSR10.76744577
88YES10.76010871
89FGFR10.74783256
90MTOR0.72748643
91DYRK20.70342251
92EPHA30.69871790
93AURKA0.69498028
94PRKCE0.68991975
95CDK80.68176491
96PTK60.67830027
97VRK10.67594690
98CCNB10.66753476
99BCKDK0.65827861
100PINK10.65734485
101PLK20.64655777
102EPHA40.63995149
103MAP3K30.63791213
104MAP2K30.63261707
105FER0.63125201
106LRRK20.62463986
107TRPM70.62396836
108NLK0.61685665
109DYRK30.61299560
110MAP3K120.58725593
111CDK10.58541948
112ALK0.57716110
113IRAK40.56650734
114CLK10.56201849
115TESK10.55487160
116NME20.55413923
117EPHB20.55373697
118ERBB40.53481126
119PDGFRA0.52725529
120MINK10.52598460
121SCYL20.52098761
122PDK20.51917648
123PRKCG0.51408473
124CSNK2A10.51056695
125MARK30.46393709
126PBK0.45261465
127RPS6KB10.44772605
128MST40.44512100
129WNK40.44175496
130IKBKB0.43711130
131RPS6KC10.43310675
132RPS6KL10.43310675
133TIE10.43083179
134RPS6KA60.42209301
135PAK20.41882034
136CSNK2A20.41474437
137DDR20.41190356
138TXK0.39805158
139NME10.35926622
140MUSK0.35484763
141CSNK1A10.30677478
142PRKDC0.30407867
143ADRBK10.27520208
144MAP2K70.25878470
145PTK2B0.24105198
146PRKCI0.23110178
147CAMK2D0.23093380
148CSNK1D0.23092478
149ROCK20.22879078
150PKN10.21366123
151CAMK2A0.20764554

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.59346586
2Protein export_Homo sapiens_hsa030603.51779834
3Mismatch repair_Homo sapiens_hsa034303.25721380
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11195254
5One carbon pool by folate_Homo sapiens_hsa006703.03810811
6Cell cycle_Homo sapiens_hsa041102.86140554
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.83076504
8RNA transport_Homo sapiens_hsa030132.81479503
9Spliceosome_Homo sapiens_hsa030402.68830853
10Propanoate metabolism_Homo sapiens_hsa006402.67282172
11Base excision repair_Homo sapiens_hsa034102.49457242
12Steroid biosynthesis_Homo sapiens_hsa001002.22110326
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20799001
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20566265
15Homologous recombination_Homo sapiens_hsa034402.20270665
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14380216
17Nucleotide excision repair_Homo sapiens_hsa034202.04873017
18mRNA surveillance pathway_Homo sapiens_hsa030151.96857479
19Vitamin B6 metabolism_Homo sapiens_hsa007501.95496791
20Fatty acid elongation_Homo sapiens_hsa000621.92320741
21p53 signaling pathway_Homo sapiens_hsa041151.84736248
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84632387
23Fanconi anemia pathway_Homo sapiens_hsa034601.78170211
24Butanoate metabolism_Homo sapiens_hsa006501.75122216
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69000604
26RNA degradation_Homo sapiens_hsa030181.68696149
27Proteasome_Homo sapiens_hsa030501.67861474
28Non-homologous end-joining_Homo sapiens_hsa034501.66558349
29RNA polymerase_Homo sapiens_hsa030201.66256197
30Pyrimidine metabolism_Homo sapiens_hsa002401.46217657
31MicroRNAs in cancer_Homo sapiens_hsa052061.44531063
32Basal transcription factors_Homo sapiens_hsa030221.43917691
33Adherens junction_Homo sapiens_hsa045201.40997040
34Herpes simplex infection_Homo sapiens_hsa051681.38965792
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35374698
36Pyruvate metabolism_Homo sapiens_hsa006201.30214161
37Legionellosis_Homo sapiens_hsa051341.27666465
38Thyroid cancer_Homo sapiens_hsa052161.25493115
39Small cell lung cancer_Homo sapiens_hsa052221.25426298
40Oxidative phosphorylation_Homo sapiens_hsa001901.24277208
41Epstein-Barr virus infection_Homo sapiens_hsa051691.23542928
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23100675
43Selenocompound metabolism_Homo sapiens_hsa004501.22365384
44Viral carcinogenesis_Homo sapiens_hsa052031.21926942
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20507818
46HTLV-I infection_Homo sapiens_hsa051661.20195758
47Hippo signaling pathway_Homo sapiens_hsa043901.19173829
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19134603
49TGF-beta signaling pathway_Homo sapiens_hsa043501.18288980
50Antigen processing and presentation_Homo sapiens_hsa046121.18212023
51Phototransduction_Homo sapiens_hsa047441.17493837
52Basal cell carcinoma_Homo sapiens_hsa052171.16745623
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11808046
54Parkinsons disease_Homo sapiens_hsa050121.11442621
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.08667410
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06922009
57Ribosome_Homo sapiens_hsa030101.06400539
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05027866
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03494396
60Nitrogen metabolism_Homo sapiens_hsa009101.02465972
61Viral myocarditis_Homo sapiens_hsa054161.01633336
62Tryptophan metabolism_Homo sapiens_hsa003800.98008354
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97483586
64Measles_Homo sapiens_hsa051620.97149666
65Chronic myeloid leukemia_Homo sapiens_hsa052200.94015993
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93783735
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.93292470
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91957284
69Fatty acid metabolism_Homo sapiens_hsa012120.91228372
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90189079
71Caffeine metabolism_Homo sapiens_hsa002320.90031058
72Hepatitis B_Homo sapiens_hsa051610.87585834
73Notch signaling pathway_Homo sapiens_hsa043300.85315010
74Apoptosis_Homo sapiens_hsa042100.84766421
75Peroxisome_Homo sapiens_hsa041460.84556235
76Influenza A_Homo sapiens_hsa051640.83903011
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83836766
78Glutathione metabolism_Homo sapiens_hsa004800.82992151
79Prostate cancer_Homo sapiens_hsa052150.82983165
80Systemic lupus erythematosus_Homo sapiens_hsa053220.82932982
81Ether lipid metabolism_Homo sapiens_hsa005650.82469193
82Colorectal cancer_Homo sapiens_hsa052100.81700895
83Leishmaniasis_Homo sapiens_hsa051400.81585741
84beta-Alanine metabolism_Homo sapiens_hsa004100.80682116
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80232702
86Huntingtons disease_Homo sapiens_hsa050160.78931314
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77987715
88Sulfur metabolism_Homo sapiens_hsa009200.77862855
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.77526752
90Proteoglycans in cancer_Homo sapiens_hsa052050.76553470
91Shigellosis_Homo sapiens_hsa051310.75875399
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74332044
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73896020
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73798711
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71947256
96Hedgehog signaling pathway_Homo sapiens_hsa043400.70248016
97Fatty acid degradation_Homo sapiens_hsa000710.70132420
98Endometrial cancer_Homo sapiens_hsa052130.68623819
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68258382
100Bladder cancer_Homo sapiens_hsa052190.67374575
101Metabolic pathways_Homo sapiens_hsa011000.65786378
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65686187
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65440430
104Lysine degradation_Homo sapiens_hsa003100.65312829
105Pathways in cancer_Homo sapiens_hsa052000.64176985
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63708869
107Linoleic acid metabolism_Homo sapiens_hsa005910.63643387
108Regulation of autophagy_Homo sapiens_hsa041400.62890317
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.62713478
110Pancreatic cancer_Homo sapiens_hsa052120.60728531
111Graft-versus-host disease_Homo sapiens_hsa053320.60463348
112Toxoplasmosis_Homo sapiens_hsa051450.60382681
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.58721252
114TNF signaling pathway_Homo sapiens_hsa046680.58713924
115Allograft rejection_Homo sapiens_hsa053300.58025601
116Oocyte meiosis_Homo sapiens_hsa041140.57992121
117Melanoma_Homo sapiens_hsa052180.57856115
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57746836
119Carbon metabolism_Homo sapiens_hsa012000.57602491
120Circadian rhythm_Homo sapiens_hsa047100.56025255
121Acute myeloid leukemia_Homo sapiens_hsa052210.55840230
122Purine metabolism_Homo sapiens_hsa002300.54698356
123Folate biosynthesis_Homo sapiens_hsa007900.54493875
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53902404
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52912598
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52098948
127Wnt signaling pathway_Homo sapiens_hsa043100.51015392
128HIF-1 signaling pathway_Homo sapiens_hsa040660.50280805
129FoxO signaling pathway_Homo sapiens_hsa040680.49989294
130Focal adhesion_Homo sapiens_hsa045100.49527315
131ECM-receptor interaction_Homo sapiens_hsa045120.49400874
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.48571936
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47229490
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46841947
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46500932
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.46258497
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45373395
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44340239
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44094378
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.43010059
141Hematopoietic cell lineage_Homo sapiens_hsa046400.42738125
142Collecting duct acid secretion_Homo sapiens_hsa049660.42584123
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41934696
144Retinol metabolism_Homo sapiens_hsa008300.41415176
145Alzheimers disease_Homo sapiens_hsa050100.40156985
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39372182
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.38039079
148N-Glycan biosynthesis_Homo sapiens_hsa005100.37859953
149mTOR signaling pathway_Homo sapiens_hsa041500.36407652
150Primary immunodeficiency_Homo sapiens_hsa053400.36293890
151Chemical carcinogenesis_Homo sapiens_hsa052040.35953071
152Biosynthesis of amino acids_Homo sapiens_hsa012300.35329083
153Nicotine addiction_Homo sapiens_hsa050330.35166734
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.35035460
155Malaria_Homo sapiens_hsa051440.34194444
156Vitamin digestion and absorption_Homo sapiens_hsa049770.34033425
157Tight junction_Homo sapiens_hsa045300.33005659
158Asthma_Homo sapiens_hsa053100.31852402
159Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30390138
160Steroid hormone biosynthesis_Homo sapiens_hsa001400.30295113
161Arginine and proline metabolism_Homo sapiens_hsa003300.29197060
162Sphingolipid metabolism_Homo sapiens_hsa006000.26543697
163Fat digestion and absorption_Homo sapiens_hsa049750.23837923
164Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23291297

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