MAPK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.92464554
2detection of temperature stimulus involved in sensory perception (GO:0050961)3.92464554
3desmosome organization (GO:0002934)3.88281519
4cell-substrate junction assembly (GO:0007044)3.67921347
5detection of temperature stimulus (GO:0016048)3.61722301
6synaptic vesicle docking involved in exocytosis (GO:0016081)3.51214641
7cytoskeletal anchoring at plasma membrane (GO:0007016)3.42755245
8negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.40093955
9synaptic vesicle maturation (GO:0016188)3.36058703
10sodium ion export (GO:0071436)3.29802351
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.24732236
12bundle of His cell to Purkinje myocyte communication (GO:0086069)3.15130106
13cell communication involved in cardiac conduction (GO:0086065)3.03716988
14neurofilament cytoskeleton organization (GO:0060052)2.96662915
15proline transport (GO:0015824)2.92518175
16regulation of amyloid precursor protein catabolic process (GO:1902991)2.87779997
17membrane repolarization (GO:0086009)2.85072091
18protein localization to endosome (GO:0036010)2.82332657
19negative regulation of microtubule polymerization (GO:0031115)2.79545297
20cellular potassium ion homeostasis (GO:0030007)2.78634851
21actin filament depolymerization (GO:0030042)2.75063149
22membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74147086
23signal complex assembly (GO:0007172)2.73236760
24positive regulation of Cdc42 GTPase activity (GO:0043089)2.71730244
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66361586
26protein targeting to plasma membrane (GO:0072661)2.65985959
27protein retention in ER lumen (GO:0006621)2.64842845
28adenosine receptor signaling pathway (GO:0001973)2.64252040
29membrane budding (GO:0006900)2.63531951
30negative regulation of erythrocyte differentiation (GO:0045647)2.63491165
31plasma membrane repair (GO:0001778)2.62675623
32glycine transport (GO:0015816)2.62403802
33layer formation in cerebral cortex (GO:0021819)2.62249090
34cell migration in hindbrain (GO:0021535)2.62052151
35positive regulation of synapse maturation (GO:0090129)2.57264923
36cellular response to pH (GO:0071467)2.55537585
37cellular response to nerve growth factor stimulus (GO:1990090)2.54939195
38response to nerve growth factor (GO:1990089)2.54939195
39stress fiber assembly (GO:0043149)2.54568633
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.53129448
41renal filtration (GO:0097205)2.52940347
42regulation of extracellular matrix disassembly (GO:0010715)2.51337473
43L-amino acid import (GO:0043092)2.50716553
44regulation of synaptic vesicle exocytosis (GO:2000300)2.49761430
45membrane repolarization during action potential (GO:0086011)2.48996765
46regulation of T-helper 2 cell differentiation (GO:0045628)2.48150726
47amino acid import (GO:0043090)2.47543828
48synaptic vesicle exocytosis (GO:0016079)2.47227673
49regulation of short-term neuronal synaptic plasticity (GO:0048172)2.47066419
50activation of protein kinase A activity (GO:0034199)2.46212452
51axon cargo transport (GO:0008088)2.46184130
52regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.45320720
53nerve growth factor signaling pathway (GO:0038180)2.44230254
54regulation of cholesterol homeostasis (GO:2000188)2.41195316
55* peptidyl-tyrosine autophosphorylation (GO:0038083)2.39986863
56hemidesmosome assembly (GO:0031581)2.39714558
57negative regulation of potassium ion transmembrane transport (GO:1901380)2.39228700
58glutamate secretion (GO:0014047)2.38420480
59negative regulation of calcium ion transport into cytosol (GO:0010523)2.37019961
60neuronal action potential propagation (GO:0019227)2.36227631
61response to lipoprotein particle (GO:0055094)2.35957030
62neuronal action potential (GO:0019228)2.35751114
63glomerular filtration (GO:0003094)2.35218242
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35057016
65negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.34807622
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.34661301
67regulation of ARF GTPase activity (GO:0032312)2.34230453
68positive regulation of protein dephosphorylation (GO:0035307)2.32706075
69myelin maintenance (GO:0043217)2.31820573
70adhesion of symbiont to host (GO:0044406)2.30679429
71potassium ion import (GO:0010107)2.29176591
72adhesion of symbiont to host cell (GO:0044650)2.28777291
73virion attachment to host cell (GO:0019062)2.28777291
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.27715950
75barbed-end actin filament capping (GO:0051016)2.26618137
76neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.25788032
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.24883117
78focal adhesion assembly (GO:0048041)2.24828543
79cell-substrate adherens junction assembly (GO:0007045)2.24828543
80cell communication by electrical coupling (GO:0010644)2.24766441
81positive regulation of pseudopodium assembly (GO:0031274)2.24463471
82potassium ion homeostasis (GO:0055075)2.23768253
83angiotensin maturation (GO:0002003)2.23627896
84mannose metabolic process (GO:0006013)2.22175895
85artery development (GO:0060840)2.21795884
86locomotory exploration behavior (GO:0035641)2.21393489
87mating behavior (GO:0007617)2.21179828
88adherens junction assembly (GO:0034333)2.19347293
89negative regulation of protein polymerization (GO:0032272)2.18763998
90regulation of guanylate cyclase activity (GO:0031282)2.18174587
91enteric nervous system development (GO:0048484)2.17561157
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.16912502
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.16912502
94modulation by symbiont of host immune response (GO:0052553)2.16912502
95positive regulation by symbiont of host defense response (GO:0052509)2.16912502
96modulation by symbiont of host defense response (GO:0052031)2.16912502
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.16912502
98regulation of regulated secretory pathway (GO:1903305)2.16781394
99neuronal ion channel clustering (GO:0045161)2.15991948
100peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.15690268
101regulation of ARF protein signal transduction (GO:0032012)2.15033633
102semaphorin-plexin signaling pathway (GO:0071526)2.14756792
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.14589231
104positive regulation of synaptic transmission, GABAergic (GO:0032230)2.13307404
105sexual reproduction (GO:0019953)2.13143855
106cellular sodium ion homeostasis (GO:0006883)2.12703605
107membrane depolarization during action potential (GO:0086010)2.12637962
108antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.12471518
109negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.11827525
110dopamine receptor signaling pathway (GO:0007212)2.11499862
111surfactant homeostasis (GO:0043129)2.11430692
112regulation of water loss via skin (GO:0033561)2.11026471
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.10627124
114sperm capacitation (GO:0048240)2.10514182
115actin filament capping (GO:0051693)2.10052281
116positive regulation of potassium ion transport (GO:0043268)2.09539779
117negative regulation of actin filament polymerization (GO:0030837)2.09486736
118negative regulation of cell killing (GO:0031342)2.08040515
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.08040515
120L-serine transport (GO:0015825)2.07523633
121response to acidic pH (GO:0010447)2.07437508
122cerebellar granule cell differentiation (GO:0021707)2.06873524
123neurotransmitter secretion (GO:0007269)2.06843960
124vesicle transport along microtubule (GO:0047496)2.06689281
125regulation of synaptic vesicle transport (GO:1902803)2.06627611
126regulation of leukocyte degranulation (GO:0043300)2.06582054
127positive regulation of potassium ion transmembrane transport (GO:1901381)2.05980087
128response to water (GO:0009415)2.05709458
129positive regulation of receptor recycling (GO:0001921)2.05450299
130protein maturation by protein folding (GO:0022417)2.05278159
131positive regulation of fatty acid beta-oxidation (GO:0032000)2.03566513
132cell-cell junction maintenance (GO:0045217)2.02373632
133sodium ion transmembrane transport (GO:0035725)2.02074489
134regulation of synapse maturation (GO:0090128)2.01821263
135establishment of protein localization to plasma membrane (GO:0090002)2.01307400
136cellular response to nicotine (GO:0071316)2.00836171
137negative regulation of ion transmembrane transporter activity (GO:0032413)2.00427169
138dendritic spine organization (GO:0097061)1.99804312
139regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)1.99557790
140intermediate filament organization (GO:0045109)1.98951079
141positive regulation of Rap GTPase activity (GO:0032854)1.98579208
142receptor catabolic process (GO:0032801)1.98424991
143* regulation of early endosome to late endosome transport (GO:2000641)1.97764437
144negative regulation of cation channel activity (GO:2001258)1.97340857
145negative regulation of leukocyte chemotaxis (GO:0002689)1.97071411
146regulation of protein dephosphorylation (GO:0035304)1.96824661
147membrane tubulation (GO:0097320)1.96647116
148negative regulation of dendrite morphogenesis (GO:0050774)1.96447167
149regulation of synapse structural plasticity (GO:0051823)1.95970131
150potassium ion export (GO:0071435)1.95879063
151renal system process involved in regulation of blood volume (GO:0001977)1.95317647
152antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.95248807
153alanine transport (GO:0032328)1.94855371
154sodium ion homeostasis (GO:0055078)1.94651315
155neuromuscular process controlling balance (GO:0050885)1.93813669
156positive regulation of regulated secretory pathway (GO:1903307)1.93314451
157regulation of beta-amyloid formation (GO:1902003)1.93169995
158epithelial cell differentiation involved in prostate gland development (GO:0060742)1.92834360
159hypotonic response (GO:0006971)1.91800965
160negative regulation of ion transmembrane transport (GO:0034766)1.91272828
161negative regulation of GTP catabolic process (GO:0033125)1.91202786
162negative regulation of GTPase activity (GO:0034260)1.91202786
163regulation of actin filament depolymerization (GO:0030834)1.90880131
164regulation of clathrin-mediated endocytosis (GO:2000369)1.90761813
165peripheral nervous system neuron development (GO:0048935)1.90651027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66948760
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.49141842
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.20459699
4TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01643054
5CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88589663
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87371317
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86480956
8MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85171116
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83994401
10RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81697891
11KDM2B_26808549_Chip-Seq_K562_Human1.77653169
12JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73679928
13EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70973496
14RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70973496
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69989971
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68470299
17P68_20966046_ChIP-Seq_HELA_Human1.63991179
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63196844
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61366002
20SMC4_20622854_ChIP-Seq_HELA_Human1.60825747
21LXR_22292898_ChIP-Seq_THP-1_Human1.60699641
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59656133
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58065872
24VDR_21846776_ChIP-Seq_THP-1_Human1.57999055
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55082722
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.54470875
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54240081
28ZNF263_19887448_ChIP-Seq_K562_Human1.53400945
29TCF7_22412390_ChIP-Seq_EML_Mouse1.51718026
30DROSHA_22980978_ChIP-Seq_HELA_Human1.49478351
31RACK7_27058665_Chip-Seq_MCF-7_Human1.48277558
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48205355
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.45252086
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45052866
35SOX2_20726797_ChIP-Seq_SW620_Human1.42774770
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.40434656
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.39365928
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38696812
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38365527
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37187710
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34735078
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.34595480
43CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34578878
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33277907
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.32798343
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.31507276
47BCOR_27268052_Chip-Seq_Bcells_Human1.29452712
48CTCF_27219007_Chip-Seq_Bcells_Human1.28967648
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28509597
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.27209105
51* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25334760
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.24874382
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24689688
54KDM2B_26808549_Chip-Seq_DND41_Human1.23772479
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23264479
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22646598
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.21989549
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.21846824
59* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21400718
60BCL6_27268052_Chip-Seq_Bcells_Human1.20582979
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20289649
62SA1_27219007_Chip-Seq_Bcells_Human1.20072003
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19921340
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19897514
65* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19493583
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19014650
67* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18634216
68* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18533649
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18128385
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17246893
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16535772
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.16271714
73VDR_24763502_ChIP-Seq_THP-1_Human1.14931558
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14640938
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14502502
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14480270
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.14142713
78* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13989181
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13749551
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.13281091
81AHR_22903824_ChIP-Seq_MCF-7_Human1.11976129
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.11791872
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11545009
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11026933
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10152411
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10148839
87* KLF5_25053715_ChIP-Seq_YYC3_Human1.09252260
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09212512
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09195963
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08801576
91* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08641750
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08285860
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.07603444
94GATA1_19941826_ChIP-Seq_K562_Human1.06874499
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.06405952
96CREB1_26743006_Chip-Seq_LNCaP_Human1.05623005
97E2F1_20622854_ChIP-Seq_HELA_Human1.05612327
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05158934
99JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03090698
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02565360
101CTCF_20526341_ChIP-Seq_ESCs_Human1.02547262
102OCT4_19829295_ChIP-Seq_ESCs_Human1.02453754
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02257320
104* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02036535
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01328806
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99969698
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99503039
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99020015
109EZH2_22144423_ChIP-Seq_EOC_Human0.98812939
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.98512150
111SPI1_23127762_ChIP-Seq_K562_Human0.98450502
112CLOCK_20551151_ChIP-Seq_293T_Human0.98382625
113* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97921105
114RXR_22158963_ChIP-Seq_LIVER_Mouse0.97669556
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97549076
116PHF8_20622854_ChIP-Seq_HELA_Human0.97152597
117PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96799591
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.96375585
119TP53_22127205_ChIP-Seq_IMR90_Human0.96354889
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96336427
121TP63_22573176_ChIP-Seq_HFKS_Human0.96065246
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95018972
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94899471
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94714297
125REST_21632747_ChIP-Seq_MESCs_Mouse0.94382435
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93816363
127KLF4_19829295_ChIP-Seq_ESCs_Human0.93751766
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92683690
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91070134
130ATF3_27146783_Chip-Seq_COLON_Human0.90429784
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89736872
132CJUN_26792858_Chip-Seq_BT549_Human0.89364062
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88597733
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88546181
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.88191677
136TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87794658
137* SA1_27219007_Chip-Seq_ERYTHROID_Human0.86589915
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.86581989
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.85519918
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85362530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system3.90656982
2MP0010234_abnormal_vibrissa_follicle3.53484058
3MP0004270_analgesia3.47067472
4MP0002735_abnormal_chemical_nociception3.36024355
5MP0001968_abnormal_touch/_nociception3.14218730
6MP0002733_abnormal_thermal_nociception3.09187187
7MP0002736_abnormal_nociception_after2.93257679
8MP0004859_abnormal_synaptic_plasticity2.90796644
9MP0005409_darkened_coat_color2.89817704
10MP0005058_abnormal_lysosome_morphology2.85546232
11MP0005167_abnormal_blood-brain_barrier2.76446223
12MP0001970_abnormal_pain_threshold2.60993606
13MP0002822_catalepsy2.52765452
14MP0002734_abnormal_mechanical_nocicepti2.50852673
15MP0005257_abnormal_intraocular_pressure2.47640438
16MP0000678_abnormal_parathyroid_gland2.41857413
17MP0003283_abnormal_digestive_organ2.21948203
18MP0005360_urolithiasis2.06013048
19MP0003300_gastrointestinal_ulcer1.99615662
20MP0002909_abnormal_adrenal_gland1.93516094
21MP0003329_amyloid_beta_deposits1.91803617
22MP0003303_peritoneal_inflammation1.84815578
23MP0004381_abnormal_hair_follicle1.81120274
24MP0001986_abnormal_taste_sensitivity1.79623380
25MP0010386_abnormal_urinary_bladder1.79530551
26MP0000920_abnormal_myelination1.77087135
27MP0009780_abnormal_chondrocyte_physiolo1.76667610
28MP0000013_abnormal_adipose_tissue1.69344120
29MP0003436_decreased_susceptibility_to1.67905563
30MP0000467_abnormal_esophagus_morphology1.63771524
31MP0003705_abnormal_hypodermis_morpholog1.59163232
32MP0004185_abnormal_adipocyte_glucose1.55564424
33MP0004264_abnormal_extraembryonic_tissu1.49852961
34MP0005451_abnormal_body_composition1.48937159
35* MP0003635_abnormal_synaptic_transmissio1.46698935
36MP0002098_abnormal_vibrissa_morphology1.45057481
37MP0004510_myositis1.44801248
38MP0003183_abnormal_peptide_metabolism1.40063151
39MP0005670_abnormal_white_adipose1.39250842
40MP0003045_fibrosis1.39197830
41MP0003075_altered_response_to1.39148101
42MP0002060_abnormal_skin_morphology1.37733454
43MP0003191_abnormal_cellular_cholesterol1.35783904
44MP0003566_abnormal_cell_adhesion1.32228171
45MP0003634_abnormal_glial_cell1.31448306
46MP0000604_amyloidosis1.30024308
47MP0003724_increased_susceptibility_to1.29285847
48MP0003172_abnormal_lysosome_physiology1.26687414
49MP0002249_abnormal_larynx_morphology1.26225302
50MP0005623_abnormal_meninges_morphology1.25902668
51MP0003690_abnormal_glial_cell1.25358662
52MP0002272_abnormal_nervous_system1.24172263
53MP0001958_emphysema1.23074752
54MP0005423_abnormal_somatic_nervous1.22929508
55MP0006276_abnormal_autonomic_nervous1.22680829
56MP0005076_abnormal_cell_differentiation1.22229250
57MP0002064_seizures1.18184038
58MP0003633_abnormal_nervous_system1.18092670
59MP0001533_abnormal_skeleton_physiology1.16248119
60MP0000462_abnormal_digestive_system1.14029581
61MP0005275_abnormal_skin_tensile1.13807468
62MP0002796_impaired_skin_barrier1.11336824
63MP0001849_ear_inflammation1.11141398
64MP0000762_abnormal_tongue_morphology1.07101337
65MP0004019_abnormal_vitamin_homeostasis1.06568716
66MP0005023_abnormal_wound_healing1.06191207
67MP0001664_abnormal_digestion1.05081834
68MP0004811_abnormal_neuron_physiology1.03807115
69MP0004272_abnormal_basement_membrane1.03239620
70MP0000534_abnormal_ureter_morphology1.02659287
71MP0001216_abnormal_epidermal_layer1.02091683
72MP0002653_abnormal_ependyma_morphology0.99763793
73MP0003279_aneurysm0.99317790
74MP0000566_synostosis0.99143150
75MP0001348_abnormal_lacrimal_gland0.98701887
76MP0000538_abnormal_urinary_bladder0.98591909
77MP0003866_abnormal_defecation0.97992518
78MP0005501_abnormal_skin_physiology0.97984661
79MP0008874_decreased_physiological_sensi0.96957379
80MP0005083_abnormal_biliary_tract0.96548859
81MP0000955_abnormal_spinal_cord0.95646248
82MP0002089_abnormal_postnatal_growth/wei0.95453450
83MP0010155_abnormal_intestine_physiology0.95429670
84MP0003878_abnormal_ear_physiology0.95379330
85MP0005377_hearing/vestibular/ear_phenot0.95379330
86MP0000751_myopathy0.95173120
87MP0009840_abnormal_foam_cell0.94534380
88MP0004885_abnormal_endolymph0.94153008
89MP0004782_abnormal_surfactant_physiolog0.92617168
90MP0003880_abnormal_central_pattern0.92463268
91MP0000003_abnormal_adipose_tissue0.92200200
92MP0001765_abnormal_ion_homeostasis0.91524675
93MP0008961_abnormal_basal_metabolism0.91387569
94MP0005166_decreased_susceptibility_to0.90835410
95MP0005381_digestive/alimentary_phenotyp0.90300453
96MP0005410_abnormal_fertilization0.89403954
97MP0001756_abnormal_urination0.89186353
98MP0005666_abnormal_adipose_tissue0.87851348
99* MP0002063_abnormal_learning/memory/cond0.87606373
100MP0003091_abnormal_cell_migration0.86532042
101MP0002295_abnormal_pulmonary_circulatio0.86519628
102MP0000747_muscle_weakness0.86231129
103MP0002184_abnormal_innervation0.86065791
104MP0001663_abnormal_digestive_system0.84844243
105MP0001440_abnormal_grooming_behavior0.84231041
106MP0009745_abnormal_behavioral_response0.83443677
107MP0008569_lethality_at_weaning0.83177846
108MP0001299_abnormal_eye_distance/0.82282597
109MP0000681_abnormal_thyroid_gland0.81722356
110MP0002877_abnormal_melanocyte_morpholog0.81609774
111MP0005375_adipose_tissue_phenotype0.80461679
112MP0008438_abnormal_cutaneous_collagen0.80447707
113MP0003631_nervous_system_phenotype0.80009213
114MP0008004_abnormal_stomach_pH0.78888964
115MP0005025_abnormal_response_to0.78764953
116MP0008260_abnormal_autophagy0.77824509
117MP0004947_skin_inflammation0.76678280
118MP0002572_abnormal_emotion/affect_behav0.76374143
119MP0001270_distended_abdomen0.76352541
120MP0004043_abnormal_pH_regulation0.75670639
121MP0009931_abnormal_skin_appearance0.75478186
122MP0002067_abnormal_sensory_capabilities0.74331436
123MP0001486_abnormal_startle_reflex0.73206251
124MP0005390_skeleton_phenotype0.73082508
125MP0010771_integument_phenotype0.73062034
126MP0003453_abnormal_keratinocyte_physiol0.72633851
127MP0002882_abnormal_neuron_morphology0.71999233
128MP0004130_abnormal_muscle_cell0.71572699
129MP0002229_neurodegeneration0.71548371
130MP0009046_muscle_twitch0.70262619
131MP0003879_abnormal_hair_cell0.69431188
132MP0000377_abnormal_hair_follicle0.68701416
133MP0005310_abnormal_salivary_gland0.68303320
134MP0002896_abnormal_bone_mineralization0.67276385
135MP0000579_abnormal_nail_morphology0.65437915
136MP0002751_abnormal_autonomic_nervous0.65349785
137MP0000230_abnormal_systemic_arterial0.64007816
138MP0002998_abnormal_bone_remodeling0.63788741
139MP0001501_abnormal_sleep_pattern0.63431303
140MP0009379_abnormal_foot_pigmentation0.63135583

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.83740656
2Milia (HP:0001056)4.75005996
3Fragile nails (HP:0001808)4.71222957
4Ulnar claw (HP:0001178)4.68270768
5Segmental peripheral demyelination/remyelination (HP:0003481)4.37574405
6Onycholysis (HP:0001806)4.36237911
7Supranuclear gaze palsy (HP:0000605)4.16835165
8Action tremor (HP:0002345)3.91393676
9Termporal pattern (HP:0011008)3.73149251
10Insidious onset (HP:0003587)3.73149251
11Abnormality of nail color (HP:0100643)3.61226949
12Plantar hyperkeratosis (HP:0007556)3.55226588
13Neurofibrillary tangles (HP:0002185)3.17009635
14Axonal loss (HP:0003447)3.07159899
15Peripheral hypomyelination (HP:0007182)3.05151955
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.97038178
17Onion bulb formation (HP:0003383)2.93389743
18Ankle clonus (HP:0011448)2.83976534
19Amelogenesis imperfecta (HP:0000705)2.78863594
20Pheochromocytoma (HP:0002666)2.77863693
21Increased cerebral lipofuscin (HP:0011813)2.76742179
22Dysostosis multiplex (HP:0000943)2.75935265
23Hypercortisolism (HP:0001578)2.74401035
24Cerebral inclusion bodies (HP:0100314)2.71644358
25Fragile skin (HP:0001030)2.70229122
26Abnormal blistering of the skin (HP:0008066)2.68975644
27Obstructive sleep apnea (HP:0002870)2.67658867
28Hammertoe (HP:0001765)2.66063596
29Diplopia (HP:0000651)2.65907139
30Abnormality of binocular vision (HP:0011514)2.65907139
31Nail dystrophy (HP:0008404)2.64415280
32Foot dorsiflexor weakness (HP:0009027)2.62001047
33Interstitial pulmonary disease (HP:0006530)2.59669680
34Protrusio acetabuli (HP:0003179)2.57479445
35Alopecia of scalp (HP:0002293)2.54971376
36Postural tremor (HP:0002174)2.52415966
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49657543
38Ventricular fibrillation (HP:0001663)2.48395878
39Rapidly progressive (HP:0003678)2.48086897
40Pili torti (HP:0003777)2.45637390
41Hyperparathyroidism (HP:0000843)2.45445030
42Right ventricular cardiomyopathy (HP:0011663)2.37908742
43Increased CSF protein (HP:0002922)2.35082421
44Thick nail (HP:0001805)2.33250752
45Upper limb amyotrophy (HP:0009129)2.32684965
46Distal upper limb amyotrophy (HP:0007149)2.32684965
47Papilledema (HP:0001085)2.31850688
48Abnormality of the foot musculature (HP:0001436)2.27036450
49Hyporeflexia of lower limbs (HP:0002600)2.26752469
50Oligomenorrhea (HP:0000876)2.26374129
51Peripheral demyelination (HP:0011096)2.24806478
52Hypoplasia of dental enamel (HP:0006297)2.22383360
53Neuroendocrine neoplasm (HP:0100634)2.22302824
54Amyloidosis (HP:0011034)2.22037087
55Abnormality of the vocal cords (HP:0008777)2.21935528
56Cervical subluxation (HP:0003308)2.21175195
57Hand muscle atrophy (HP:0009130)2.20309778
58Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.19784382
59Ridged nail (HP:0001807)2.14778241
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.11367252
61Cholecystitis (HP:0001082)2.10758931
62Abnormal gallbladder physiology (HP:0012438)2.10758931
63Cerebral hemorrhage (HP:0001342)2.09222343
64Visual hallucinations (HP:0002367)2.08268721
65Mucopolysacchariduria (HP:0008155)2.05848843
66Urinary glycosaminoglycan excretion (HP:0003541)2.05848843
67Neuronal loss in central nervous system (HP:0002529)2.05415593
68Abnormality of calcium-phosphate metabolism (HP:0100530)2.05289841
69Hemorrhage of the eye (HP:0011885)2.04462279
70Hypoventilation (HP:0002791)2.03434755
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01980215
72Myotonia (HP:0002486)2.00437847
73Distal sensory impairment (HP:0002936)1.99938686
74Thin bony cortex (HP:0002753)1.99716668
75Apathy (HP:0000741)1.99132744
76Decreased motor nerve conduction velocity (HP:0003431)1.98305466
77Flat acetabular roof (HP:0003180)1.97547872
78Abnormality of the nasal mucosa (HP:0000433)1.95647717
79Failure to thrive in infancy (HP:0001531)1.93862964
80Hyperacusis (HP:0010780)1.93745144
81Adrenal overactivity (HP:0002717)1.92342778
82Steppage gait (HP:0003376)1.92106096
83Vascular tortuosity (HP:0004948)1.89975751
84Vertebral compression fractures (HP:0002953)1.89939963
85Abnormality of polysaccharide metabolism (HP:0011012)1.88777127
86Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88777127
87Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88777127
88Thoracolumbar scoliosis (HP:0002944)1.88455845
89Insomnia (HP:0100785)1.88167525
90Broad metatarsal (HP:0001783)1.86843907
91Mutism (HP:0002300)1.86397175
92Abnormal hair laboratory examination (HP:0003328)1.86384271
93Abnormality of the corticospinal tract (HP:0002492)1.86220931
94Vacuolated lymphocytes (HP:0001922)1.84947838
95Hyperactive renin-angiotensin system (HP:0000841)1.84317935
96Megalencephaly (HP:0001355)1.83684598
97Arterial tortuosity (HP:0005116)1.83554156
98Polygenic inheritance (HP:0010982)1.83397372
99Retinal atrophy (HP:0001105)1.82641255
100Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81590584
101Palmoplantar hyperkeratosis (HP:0000972)1.79844438
102Eczematoid dermatitis (HP:0000976)1.79785211
103Torticollis (HP:0000473)1.79458874
104Broad face (HP:0000283)1.79379302
105Abnormality of glycolipid metabolism (HP:0010969)1.78972210
106Abnormality of liposaccharide metabolism (HP:0010968)1.78972210
107Abnormality of glycosphingolipid metabolism (HP:0004343)1.78972210
108Asymmetric septal hypertrophy (HP:0001670)1.78537701
109Acanthosis nigricans (HP:0000956)1.77705626
110Flattened epiphyses (HP:0003071)1.76881799
111Cerebral aneurysm (HP:0004944)1.76836693
112Potter facies (HP:0002009)1.76354515
113Facial shape deformation (HP:0011334)1.76354515
114Diminished motivation (HP:0000745)1.75727923
115Bronchomalacia (HP:0002780)1.75315097
116Malnutrition (HP:0004395)1.75107685
117Postural instability (HP:0002172)1.74603685
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73941253
119Systemic lupus erythematosus (HP:0002725)1.73617647
120Neoplasm of the peripheral nervous system (HP:0100007)1.73442040
121Dysautonomia (HP:0002459)1.73193945
122Shallow orbits (HP:0000586)1.72969302
123Loss of speech (HP:0002371)1.72883380
124Achilles tendon contracture (HP:0001771)1.72848137
125Stridor (HP:0010307)1.72104118
126Buphthalmos (HP:0000557)1.71984065
127Congenital glaucoma (HP:0001087)1.70567087
128Hypotrichosis (HP:0001006)1.69721980
129Focal seizures (HP:0007359)1.68640672
130Pterygium (HP:0001059)1.67428445
131Bundle branch block (HP:0011710)1.67061841
132Increased IgE level (HP:0003212)1.66834850
133Gingivitis (HP:0000230)1.66326099
134Impaired pain sensation (HP:0007328)1.66190199
135Abnormality of pain sensation (HP:0010832)1.66190199
136Depression (HP:0000716)1.65271295
137Limb dystonia (HP:0002451)1.65030455
138Coxa vara (HP:0002812)1.64819595
139Peritonitis (HP:0002586)1.62832880
140Emphysema (HP:0002097)1.61523079
141Striae distensae (HP:0001065)1.61393817
142Rigidity (HP:0002063)1.61312962
143Atrophic scars (HP:0001075)1.61111356
144Curly hair (HP:0002212)1.61079019
145Pyloric stenosis (HP:0002021)1.60993740
146Annular pancreas (HP:0001734)1.60658298
147Focal motor seizures (HP:0011153)1.60163926
148Premature rupture of membranes (HP:0001788)1.58610256
149Growth hormone excess (HP:0000845)1.58152136
150Nasal polyposis (HP:0100582)1.58033146
151Bladder diverticulum (HP:0000015)1.57435824
152Dementia (HP:0000726)1.57410404
153Polycythemia (HP:0001901)1.57122267
154Abnormality of macrophages (HP:0004311)1.57098701
155Hydroxyprolinuria (HP:0003080)1.57007719
156Abnormality of proline metabolism (HP:0010907)1.57007719
157Distal lower limb muscle weakness (HP:0009053)1.56802772
158J-shaped sella turcica (HP:0002680)1.56691930
159Dysmetria (HP:0001310)1.56597669
160Widely patent fontanelles and sutures (HP:0004492)1.52893670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.44296225
2MAP3K93.16695510
3NTRK13.07536416
4SIK12.99725021
5PRPF4B2.72682114
6LIMK12.61355147
7LMTK22.58282356
8TRIB32.57322461
9MET2.56052290
10PRKD32.44687258
11EPHB12.41544319
12PIK3CA2.34626654
13TESK11.94352268
14RIPK11.77322587
15EPHA41.76920219
16ARAF1.75446612
17SMG11.75169672
18GRK51.71231422
19STK381.67745625
20WNK41.63629945
21PAK61.62041926
22RIPK41.56310961
23ERN11.51371850
24STK391.45670894
25NTRK31.45619074
26LATS21.42650537
27GRK61.42014435
28MINK11.40205071
29WNK11.39162369
30EPHB21.38277103
31MATK1.34518153
32PTK2B1.34223078
33PTK21.32775037
34* KSR21.23680707
35TAOK11.22011611
36PKN21.21613507
37DAPK21.20641680
38FER1.19724630
39TAOK31.18285235
40PRKD21.17577613
41LRRK21.11743616
42PRKG21.11107136
43CAMKK11.10702494
44EPHA21.09978765
45FGFR41.08435046
46PTK61.08100186
47BMX1.03355314
48* RET1.03127141
49TNK21.02488628
50SIK21.01563062
51MAP3K30.99978241
52EPHA30.99964354
53RPS6KA20.95135575
54MAP4K10.94140167
55* MAP2K10.92766866
56MAPKAPK50.91403858
57* MAP3K10.89306172
58FRK0.89276481
59UHMK10.88740657
60MAP3K120.87248070
61MAP2K30.87110559
62PRKCH0.86724266
63PDPK10.85958471
64PHKG10.85297276
65PHKG20.85297276
66DMPK0.84539075
67PDGFRA0.83563482
68TAOK20.83466628
69TESK20.82808979
70IRAK40.82246141
71MAPK120.81633869
72CDK50.81257612
73NME10.79430172
74IRAK30.79152919
75TYK20.76898901
76SCYL20.75988592
77* MAP2K20.74550644
78PAK30.72155540
79DYRK1B0.70152989
80HIPK20.68836009
81CAMK2D0.68762673
82ZAP700.68521159
83ILK0.68221427
84CSK0.67734852
85PRKD10.67146226
86TIE10.67016108
87CDK140.64900481
88CDK120.63581668
89ROCK20.61199502
90DDR20.60329532
91ALK0.59872387
92SGK2230.58883591
93SGK4940.58883591
94MAP3K60.58056963
95DAPK30.56491116
96TYRO30.55630395
97ROCK10.54539399
98NEK60.54488393
99PDK10.54138622
100SRC0.53667470
101ICK0.53171396
102FYN0.53154078
103PRKCZ0.53024572
104TBK10.52293705
105LATS10.52053555
106EEF2K0.51382546
107BRAF0.50937372
108CSF1R0.50379255
109MAPKAPK30.50290734
110PDGFRB0.49544447
111STK110.49248460
112CAMK10.47933108
113SIK30.47847112
114CAMK2B0.47081863
115MAP2K40.46919628
116FGR0.45363352
117CDC42BPA0.45108088
118RPS6KL10.45031298
119RPS6KC10.45031298
120RPS6KA60.44166407
121CDK150.43854810
122MAP3K70.43850142
123PRKCE0.43525320
124MOS0.43385552
125MST40.43331828
126TGFBR20.42465797
127MARK20.42393478
128ADRBK10.41691835
129MAP3K110.41619684
130MAP3K40.41164344
131SGK30.40876645
132PAK40.40159377
133CDK180.39996706
134CAMK2G0.39926654
135MAPK70.39353284
136CAMK1G0.38338656
137MARK10.38023055
138ABL20.37735196
139HCK0.37607980
140CDK11A0.36103313
141TTN0.35047821
142MAP3K130.34786671
143FES0.33611865

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.45014511
2Synaptic vesicle cycle_Homo sapiens_hsa047212.27839620
3Mineral absorption_Homo sapiens_hsa049782.14030667
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.08979228
5Cyanoamino acid metabolism_Homo sapiens_hsa004601.99767570
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83988333
7* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63946583
8Carbohydrate digestion and absorption_Homo sapiens_hsa049731.56069823
9Salivary secretion_Homo sapiens_hsa049701.53223865
10Collecting duct acid secretion_Homo sapiens_hsa049661.52387100
11Insulin secretion_Homo sapiens_hsa049111.49240861
12Vibrio cholerae infection_Homo sapiens_hsa051101.48447977
13Lysosome_Homo sapiens_hsa041421.47509977
14Gastric acid secretion_Homo sapiens_hsa049711.36087715
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34232163
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33451837
17Sulfur metabolism_Homo sapiens_hsa009201.30821012
18Endocytosis_Homo sapiens_hsa041441.27798592
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26200037
20* Cholinergic synapse_Homo sapiens_hsa047251.18092858
21Dopaminergic synapse_Homo sapiens_hsa047281.16496883
22Bile secretion_Homo sapiens_hsa049761.16055298
23* Type II diabetes mellitus_Homo sapiens_hsa049301.13046503
24Pancreatic secretion_Homo sapiens_hsa049721.10848436
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10333665
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09946572
27Tight junction_Homo sapiens_hsa045301.06519021
28* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04954581
29* Dorso-ventral axis formation_Homo sapiens_hsa043201.04818430
30* Estrogen signaling pathway_Homo sapiens_hsa049151.04208998
31Notch signaling pathway_Homo sapiens_hsa043301.02963986
32* GnRH signaling pathway_Homo sapiens_hsa049121.02862738
33* Salmonella infection_Homo sapiens_hsa051321.01381197
34* Acute myeloid leukemia_Homo sapiens_hsa052211.01120133
35* VEGF signaling pathway_Homo sapiens_hsa043701.00254277
36Cocaine addiction_Homo sapiens_hsa050301.00232508
37Renin secretion_Homo sapiens_hsa049241.00068537
38Phagosome_Homo sapiens_hsa041451.00068109
39Olfactory transduction_Homo sapiens_hsa047400.98831558
40Amoebiasis_Homo sapiens_hsa051460.98690527
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98654618
42* Neurotrophin signaling pathway_Homo sapiens_hsa047220.96889311
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.93499180
44* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92842110
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91377692
46* Prion diseases_Homo sapiens_hsa050200.90992328
47* Glioma_Homo sapiens_hsa052140.90830180
48* Gap junction_Homo sapiens_hsa045400.90821404
49* Phospholipase D signaling pathway_Homo sapiens_hsa040720.90593986
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89809200
51* Sphingolipid signaling pathway_Homo sapiens_hsa040710.88687986
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87749256
53* Axon guidance_Homo sapiens_hsa043600.87701100
54Thyroid hormone synthesis_Homo sapiens_hsa049180.87260539
55* Circadian entrainment_Homo sapiens_hsa047130.85318181
56PPAR signaling pathway_Homo sapiens_hsa033200.85301194
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84207214
58* Long-term potentiation_Homo sapiens_hsa047200.84099741
59Fructose and mannose metabolism_Homo sapiens_hsa000510.83014335
60Protein digestion and absorption_Homo sapiens_hsa049740.82337763
61* Osteoclast differentiation_Homo sapiens_hsa043800.82235608
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.81713107
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81682845
64Vitamin digestion and absorption_Homo sapiens_hsa049770.81025751
65Inositol phosphate metabolism_Homo sapiens_hsa005620.80596776
66GABAergic synapse_Homo sapiens_hsa047270.80238685
67* Renal cell carcinoma_Homo sapiens_hsa052110.78725406
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.78079808
69Rheumatoid arthritis_Homo sapiens_hsa053230.77968474
70* Vascular smooth muscle contraction_Homo sapiens_hsa042700.77184935
71Galactose metabolism_Homo sapiens_hsa000520.76481748
72* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75452425
73* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73493712
74* Toxoplasmosis_Homo sapiens_hsa051450.72871853
75* Choline metabolism in cancer_Homo sapiens_hsa052310.72732355
76Fatty acid biosynthesis_Homo sapiens_hsa000610.72100815
77Amphetamine addiction_Homo sapiens_hsa050310.71849092
78* B cell receptor signaling pathway_Homo sapiens_hsa046620.70812845
79* Glutamatergic synapse_Homo sapiens_hsa047240.70512807
80Histidine metabolism_Homo sapiens_hsa003400.69736469
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.69151935
82* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68928799
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68321195
84Taste transduction_Homo sapiens_hsa047420.68212397
85Arginine biosynthesis_Homo sapiens_hsa002200.67780466
86* Oxytocin signaling pathway_Homo sapiens_hsa049210.67621040
87* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67551693
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67373524
89Renin-angiotensin system_Homo sapiens_hsa046140.67029182
90* Focal adhesion_Homo sapiens_hsa045100.66654280
91* Rap1 signaling pathway_Homo sapiens_hsa040150.66256177
92Ether lipid metabolism_Homo sapiens_hsa005650.65924833
93Sphingolipid metabolism_Homo sapiens_hsa006000.65664131
94* Long-term depression_Homo sapiens_hsa047300.65137860
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64029777
96* Thyroid cancer_Homo sapiens_hsa052160.63356963
97* Serotonergic synapse_Homo sapiens_hsa047260.63195482
98Morphine addiction_Homo sapiens_hsa050320.62959544
99* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62565238
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62365161
101* ErbB signaling pathway_Homo sapiens_hsa040120.62215851
102* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62157163
103* Tuberculosis_Homo sapiens_hsa051520.60693462
104* Chemokine signaling pathway_Homo sapiens_hsa040620.59944643
105* Platelet activation_Homo sapiens_hsa046110.59850702
106Calcium signaling pathway_Homo sapiens_hsa040200.59789299
107* Leishmaniasis_Homo sapiens_hsa051400.59691680
108* Ras signaling pathway_Homo sapiens_hsa040140.58980014
109AMPK signaling pathway_Homo sapiens_hsa041520.58929368
110* Proteoglycans in cancer_Homo sapiens_hsa052050.58859361
111Fat digestion and absorption_Homo sapiens_hsa049750.58402315
112* Insulin signaling pathway_Homo sapiens_hsa049100.57739314
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57642563
114* Prolactin signaling pathway_Homo sapiens_hsa049170.57561502
115* Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57543741
116* Endometrial cancer_Homo sapiens_hsa052130.57400675
117Glycerolipid metabolism_Homo sapiens_hsa005610.57256813
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57244788
119* Non-small cell lung cancer_Homo sapiens_hsa052230.57160682
120* Pertussis_Homo sapiens_hsa051330.57094405
121Nicotine addiction_Homo sapiens_hsa050330.56788260
122Arginine and proline metabolism_Homo sapiens_hsa003300.56377812
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55261002
124Other glycan degradation_Homo sapiens_hsa005110.55150672
125* cAMP signaling pathway_Homo sapiens_hsa040240.55132824
126ECM-receptor interaction_Homo sapiens_hsa045120.54457915
127* Melanogenesis_Homo sapiens_hsa049160.54221449
128* Central carbon metabolism in cancer_Homo sapiens_hsa052300.54146270
129Insulin resistance_Homo sapiens_hsa049310.53622567
130* Chronic myeloid leukemia_Homo sapiens_hsa052200.53117040
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50928939

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