MAPK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.64568483
2locomotory exploration behavior (GO:0035641)5.60930163
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42045118
4synaptic vesicle maturation (GO:0016188)5.20350992
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.19843859
6vocalization behavior (GO:0071625)5.08027992
7synaptic vesicle exocytosis (GO:0016079)4.94809250
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.89214032
9glutamate secretion (GO:0014047)4.83310538
10neurotransmitter-gated ion channel clustering (GO:0072578)4.82471016
11regulation of glutamate receptor signaling pathway (GO:1900449)4.79605089
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76320649
13protein localization to synapse (GO:0035418)4.60507573
14regulation of synaptic vesicle exocytosis (GO:2000300)4.56481370
15cellular potassium ion homeostasis (GO:0030007)4.46589264
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.41335554
17central nervous system myelination (GO:0022010)4.36164163
18axon ensheathment in central nervous system (GO:0032291)4.36164163
19neuron cell-cell adhesion (GO:0007158)4.34808013
20neuronal ion channel clustering (GO:0045161)4.32000697
21regulation of neuronal synaptic plasticity (GO:0048168)4.25341124
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.22330106
23potassium ion homeostasis (GO:0055075)4.19369980
24regulation of synapse structural plasticity (GO:0051823)4.19285167
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12993120
26layer formation in cerebral cortex (GO:0021819)4.12437823
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11489854
28neurotransmitter secretion (GO:0007269)4.10699850
29glutamate receptor signaling pathway (GO:0007215)4.10659092
30exploration behavior (GO:0035640)4.10569787
31synaptic transmission, glutamatergic (GO:0035249)4.09923076
32positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.07677050
33response to auditory stimulus (GO:0010996)4.07675941
34cell communication by electrical coupling (GO:0010644)4.07119517
35regulation of synaptic vesicle transport (GO:1902803)4.06917408
36neuronal action potential propagation (GO:0019227)4.02873086
37auditory behavior (GO:0031223)4.01487002
38dendritic spine morphogenesis (GO:0060997)3.95516465
39sodium ion export (GO:0071436)3.94992548
40gamma-aminobutyric acid transport (GO:0015812)3.92623846
41neuron-neuron synaptic transmission (GO:0007270)3.84291666
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.81873205
43long-term memory (GO:0007616)3.79045533
44cell communication involved in cardiac conduction (GO:0086065)3.68376929
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67495002
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.65124020
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.63254130
48postsynaptic membrane organization (GO:0001941)3.60586790
49L-amino acid import (GO:0043092)3.59375477
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.59125582
51positive regulation of membrane potential (GO:0045838)3.56282735
52regulation of postsynaptic membrane potential (GO:0060078)3.50823486
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50385682
54regulation of synaptic plasticity (GO:0048167)3.49361600
55long-term synaptic potentiation (GO:0060291)3.47980220
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47101617
57regulation of voltage-gated calcium channel activity (GO:1901385)3.46252668
58proline transport (GO:0015824)3.43948451
59regulation of dendritic spine morphogenesis (GO:0061001)3.41670794
60positive regulation of synapse maturation (GO:0090129)3.39263792
61transmission of nerve impulse (GO:0019226)3.39018464
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38437910
63neuromuscular process controlling balance (GO:0050885)3.37376725
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37229579
65regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.35068550
66positive regulation of neurotransmitter secretion (GO:0001956)3.34136998
67neurotransmitter transport (GO:0006836)3.33448078
68mechanosensory behavior (GO:0007638)3.31857240
69presynaptic membrane assembly (GO:0097105)3.31009125
70regulation of synapse maturation (GO:0090128)3.30183708
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.25722255
72positive regulation of neurotransmitter transport (GO:0051590)3.24334600
73regulation of cardiac muscle cell contraction (GO:0086004)3.22329429
74regulation of neurotransmitter secretion (GO:0046928)3.21304299
75regulation of cell communication by electrical coupling (GO:0010649)3.21126795
76regulation of female receptivity (GO:0045924)3.20932612
77amino acid import (GO:0043090)3.20647997
78neuron recognition (GO:0008038)3.17105549
79dendrite morphogenesis (GO:0048813)3.16283708
80regulation of vesicle fusion (GO:0031338)3.13337667
81potassium ion import (GO:0010107)3.13185657
82neurotransmitter uptake (GO:0001504)3.13146838
83regulation of neurotransmitter levels (GO:0001505)3.13054700
84response to histamine (GO:0034776)3.12287773
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10803750
86regulation of membrane repolarization (GO:0060306)3.10139317
87cerebellar Purkinje cell differentiation (GO:0021702)3.10073669
88regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.07882696
89synapse assembly (GO:0007416)3.07760195
90detection of calcium ion (GO:0005513)3.06612256
91membrane repolarization (GO:0086009)3.06309168
92regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06266685
93axonal fasciculation (GO:0007413)3.05746262
94prepulse inhibition (GO:0060134)3.05222635
95dendritic spine organization (GO:0097061)3.05103094
96synaptic vesicle endocytosis (GO:0048488)3.04556036
97regulation of neurotransmitter transport (GO:0051588)3.04371898
98activation of protein kinase A activity (GO:0034199)3.04153193
99membrane depolarization during action potential (GO:0086010)3.03528546
100female mating behavior (GO:0060180)3.02412761
101membrane hyperpolarization (GO:0060081)3.01540329
102positive regulation of dendritic spine development (GO:0060999)3.00536136
103positive regulation of synaptic transmission (GO:0050806)3.00361994
104presynaptic membrane organization (GO:0097090)3.00193045
105gamma-aminobutyric acid signaling pathway (GO:0007214)2.99729123
106positive regulation of potassium ion transmembrane transport (GO:1901381)2.99318955
107cerebellar granule cell differentiation (GO:0021707)2.98797490
108striatum development (GO:0021756)2.98128529
109cellular sodium ion homeostasis (GO:0006883)2.98043721
110behavioral defense response (GO:0002209)2.97914235
111behavioral fear response (GO:0001662)2.97914235
112membrane depolarization (GO:0051899)2.97834261
113regulation of dendritic spine development (GO:0060998)2.97563372
114regulation of ARF protein signal transduction (GO:0032012)2.95130981
115regulation of actin filament-based movement (GO:1903115)2.91067074
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.91010874
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90132572
118acidic amino acid transport (GO:0015800)2.85006375
119positive regulation of dendritic spine morphogenesis (GO:0061003)2.78473031
120neuromuscular process (GO:0050905)2.74817319
121positive regulation of dendrite development (GO:1900006)2.74703987
122negative regulation of dendrite morphogenesis (GO:0050774)2.74394744
123regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.71135698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17459047
2GBX2_23144817_ChIP-Seq_PC3_Human3.44912394
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17194408
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10634998
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06001186
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73542114
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73542114
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69602532
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.66027247
10REST_21632747_ChIP-Seq_MESCs_Mouse2.65365632
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62790448
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62151448
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55598947
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.55136412
15DROSHA_22980978_ChIP-Seq_HELA_Human2.50523064
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47603117
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43464612
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.41438548
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.31882497
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.22107858
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21405446
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.16075274
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01961163
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95105854
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94911502
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94083670
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87335856
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85541929
29AR_21572438_ChIP-Seq_LNCaP_Human1.79085386
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75832807
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67365219
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67081354
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66510921
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.61782709
35SMAD4_21799915_ChIP-Seq_A2780_Human1.57290658
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56266156
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54132650
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43218015
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40517783
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.40335243
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39982390
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38580326
43P300_19829295_ChIP-Seq_ESCs_Human1.36950316
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.36826199
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32060288
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.30679029
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30583823
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.29766514
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29275663
50TAF15_26573619_Chip-Seq_HEK293_Human1.29275594
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28255465
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.27996259
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25143537
54AR_25329375_ChIP-Seq_VCAP_Human1.24673001
55* AR_19668381_ChIP-Seq_PC3_Human1.24415526
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.23445270
57* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23086887
58ZNF274_21170338_ChIP-Seq_K562_Hela1.23071849
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.22637149
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22422250
61* STAT3_23295773_ChIP-Seq_U87_Human1.21201160
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19153239
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.18197023
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.17586334
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17429374
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14320024
67RXR_22108803_ChIP-Seq_LS180_Human1.13215236
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13199590
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13050247
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.12676146
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12448016
72CTCF_27219007_Chip-Seq_Bcells_Human1.10828810
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10805971
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10211483
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08750063
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08703295
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.06013130
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05710547
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05642672
80RNF2_27304074_Chip-Seq_NSC_Mouse1.05587971
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05427924
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05118477
83* TCF4_23295773_ChIP-Seq_U87_Human1.04557996
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02793376
85* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02535298
86* TET1_21490601_ChIP-Seq_MESCs_Mouse1.02014880
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01343933
88CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99541918
89KDM2B_26808549_Chip-Seq_K562_Human0.99481662
90FUS_26573619_Chip-Seq_HEK293_Human0.99168064
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98826961
92AHR_22903824_ChIP-Seq_MCF-7_Human0.98746916
93TP53_16413492_ChIP-PET_HCT116_Human0.98267399
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98023306
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98001982
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97154700
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96482765
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96482765
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96469851
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95542340
101* RUNX2_22187159_ChIP-Seq_PCA_Human0.95371094
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.95238102
103* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95194591
104* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94956509
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92538687
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92253102
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92184446
108* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92173959
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.91585209
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91012720
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90644773
112TP53_20018659_ChIP-ChIP_R1E_Mouse0.90511288
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90149398
114ISL1_27105846_Chip-Seq_CPCs_Mouse0.90010552
115BCAT_22108803_ChIP-Seq_LS180_Human0.89345247
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88519850
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88356478
118RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83451025
119* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83106747
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82688873
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81493954
122OCT4_19829295_ChIP-Seq_ESCs_Human0.77394659
123SOX9_26525672_Chip-Seq_HEART_Mouse0.76541854
124* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75430380
125LXR_22292898_ChIP-Seq_THP-1_Human0.75139061
126SMC4_20622854_ChIP-Seq_HELA_Human0.74704321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03443392
2MP0003880_abnormal_central_pattern4.30408133
3MP0003635_abnormal_synaptic_transmissio3.88872942
4MP0004270_analgesia3.76479144
5MP0002822_catalepsy3.29469869
6MP0009745_abnormal_behavioral_response3.26110920
7MP0002063_abnormal_learning/memory/cond3.22431495
8MP0002064_seizures2.92154061
9MP0001968_abnormal_touch/_nociception2.88664029
10MP0009046_muscle_twitch2.82045078
11MP0002572_abnormal_emotion/affect_behav2.74075500
12MP0001486_abnormal_startle_reflex2.72730551
13MP0005423_abnormal_somatic_nervous2.53595886
14MP0002734_abnormal_mechanical_nocicepti2.52299825
15MP0005646_abnormal_pituitary_gland2.44074131
16MP0009780_abnormal_chondrocyte_physiolo2.42963239
17MP0002272_abnormal_nervous_system2.39943931
18MP0002736_abnormal_nociception_after2.31967704
19MP0001440_abnormal_grooming_behavior2.20077523
20MP0004858_abnormal_nervous_system2.19827514
21MP0001501_abnormal_sleep_pattern2.00465685
22MP0002735_abnormal_chemical_nociception1.97669535
23MP0001984_abnormal_olfaction1.92545154
24MP0002733_abnormal_thermal_nociception1.91185894
25MP0002557_abnormal_social/conspecific_i1.89108003
26MP0002067_abnormal_sensory_capabilities1.87180998
27MP0008569_lethality_at_weaning1.86169291
28MP0000778_abnormal_nervous_system1.86023380
29MP0001970_abnormal_pain_threshold1.79640868
30MP0004885_abnormal_endolymph1.78532056
31MP0003329_amyloid_beta_deposits1.78026709
32MP0005645_abnormal_hypothalamus_physiol1.74353369
33MP0002909_abnormal_adrenal_gland1.73885304
34MP0004924_abnormal_behavior1.69245420
35MP0005386_behavior/neurological_phenoty1.69245420
36MP0002184_abnormal_innervation1.68253488
37MP0003879_abnormal_hair_cell1.60133983
38MP0003136_yellow_coat_color1.57953493
39MP0000920_abnormal_myelination1.57367812
40MP0004811_abnormal_neuron_physiology1.55242401
41MP0001529_abnormal_vocalization1.43046298
42MP0001502_abnormal_circadian_rhythm1.42040924
43MP0002882_abnormal_neuron_morphology1.41482568
44MP0000955_abnormal_spinal_cord1.40745965
45MP0003633_abnormal_nervous_system1.35592097
46MP0002066_abnormal_motor_capabilities/c1.30445121
47MP0006276_abnormal_autonomic_nervous1.28221566
48MP0003690_abnormal_glial_cell1.26511355
49MP0003123_paternal_imprinting1.26122289
50MP0003787_abnormal_imprinting1.25340568
51MP0005394_taste/olfaction_phenotype1.25208717
52MP0005499_abnormal_olfactory_system1.25208717
53MP0005171_absent_coat_pigmentation1.18330204
54MP0002152_abnormal_brain_morphology1.17464529
55MP0001485_abnormal_pinna_reflex1.16807650
56MP0003631_nervous_system_phenotype1.15566036
57MP0001188_hyperpigmentation1.14834126
58MP0000566_synostosis1.12616000
59MP0000579_abnormal_nail_morphology1.09791371
60MP0002638_abnormal_pupillary_reflex1.07458746
61MP0004142_abnormal_muscle_tone1.07420284
62MP0001905_abnormal_dopamine_level1.06911956
63MP0000631_abnormal_neuroendocrine_gland1.03139834
64MP0005551_abnormal_eye_electrophysiolog1.00161955
65MP0005409_darkened_coat_color0.98743422
66MP0003075_altered_response_to0.98146667
67MP0003183_abnormal_peptide_metabolism0.96490010
68MP0001963_abnormal_hearing_physiology0.92705456
69MP0003634_abnormal_glial_cell0.92401225
70MP0008872_abnormal_physiological_respon0.92146268
71MP0003137_abnormal_impulse_conducting0.91700963
72MP0004215_abnormal_myocardial_fiber0.91612810
73MP0002069_abnormal_eating/drinking_beha0.91547136
74MP0006292_abnormal_olfactory_placode0.90914597
75MP0002229_neurodegeneration0.88961813
76MP0000751_myopathy0.88700864
77MP0001177_atelectasis0.87399202
78MP0003283_abnormal_digestive_organ0.86219159
79MP0004085_abnormal_heartbeat0.85002330
80MP0002837_dystrophic_cardiac_calcinosis0.82380166
81MP0002752_abnormal_somatic_nervous0.82224475
82MP0003632_abnormal_nervous_system0.81712367
83MP0003122_maternal_imprinting0.77343973
84MP0008874_decreased_physiological_sensi0.77194196
85MP0004084_abnormal_cardiac_muscle0.76317352
86MP0001299_abnormal_eye_distance/0.75724109
87MP0001346_abnormal_lacrimal_gland0.73622551
88MP0008789_abnormal_olfactory_epithelium0.72187229
89MP0004130_abnormal_muscle_cell0.71344406
90MP0003878_abnormal_ear_physiology0.70996701
91MP0005377_hearing/vestibular/ear_phenot0.70996701
92MP0004742_abnormal_vestibular_system0.69150043
93MP0003861_abnormal_nervous_system0.68639522
94MP0000026_abnormal_inner_ear0.68601986
95MP0005535_abnormal_body_temperature0.68547391
96MP0001664_abnormal_digestion0.67557727
97MP0001348_abnormal_lacrimal_gland0.67533623
98MP0000013_abnormal_adipose_tissue0.67529871
99MP0008961_abnormal_basal_metabolism0.67407404
100MP0002249_abnormal_larynx_morphology0.66692528
101MP0004043_abnormal_pH_regulation0.65203808
102MP0004145_abnormal_muscle_electrophysio0.64691605
103MP0005167_abnormal_blood-brain_barrier0.64235357
104MP0010386_abnormal_urinary_bladder0.64170079
105MP0000639_abnormal_adrenal_gland0.63395687
106MP0003938_abnormal_ear_development0.63192542
107MP0002876_abnormal_thyroid_physiology0.63158175
108MP0002653_abnormal_ependyma_morphology0.62856243
109MP0003121_genomic_imprinting0.61396433
110MP0000604_amyloidosis0.61162184
111MP0000569_abnormal_digit_pigmentation0.60254707
112MP0006072_abnormal_retinal_apoptosis0.60230465
113MP0002090_abnormal_vision0.59700376
114MP0010769_abnormal_survival0.59369270
115MP0005187_abnormal_penis_morphology0.59297549
116MP0004233_abnormal_muscle_weight0.58844758
117MP0004147_increased_porphyrin_level0.58466087
118MP0001943_abnormal_respiration0.56314748
119MP0004036_abnormal_muscle_relaxation0.55651753
120MP0004510_myositis0.55644355
121MP0005248_abnormal_Harderian_gland0.55570621
122MP0010768_mortality/aging0.55483941
123MP0005253_abnormal_eye_physiology0.53691337

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.34608638
2Myokymia (HP:0002411)6.24379037
3Focal seizures (HP:0007359)5.37118119
4Epileptic encephalopathy (HP:0200134)4.74470209
5Visual hallucinations (HP:0002367)4.56633582
6Aplasia involving bones of the upper limbs (HP:0009823)4.07459249
7Aplasia of the phalanges of the hand (HP:0009802)4.07459249
8Aplasia involving bones of the extremities (HP:0009825)4.07459249
9Febrile seizures (HP:0002373)3.90138798
10Megalencephaly (HP:0001355)3.82376003
11Absence seizures (HP:0002121)3.73602840
12Atonic seizures (HP:0010819)3.73003589
13Progressive cerebellar ataxia (HP:0002073)3.67786851
14Action tremor (HP:0002345)3.61249136
15Dialeptic seizures (HP:0011146)3.49116392
16Generalized tonic-clonic seizures (HP:0002069)3.47505655
17Bundle branch block (HP:0011710)3.37665737
18Dysdiadochokinesis (HP:0002075)3.20982698
19Hyperventilation (HP:0002883)3.18477861
20Broad-based gait (HP:0002136)3.15413306
21Hemiparesis (HP:0001269)3.07871441
22Poor eye contact (HP:0000817)2.97965300
23Gaze-evoked nystagmus (HP:0000640)2.95042391
24Depression (HP:0000716)2.94577558
25Impaired vibration sensation in the lower limbs (HP:0002166)2.92713368
26Ankle clonus (HP:0011448)2.91385646
27Abnormal eating behavior (HP:0100738)2.88253865
28Truncal ataxia (HP:0002078)2.87793631
29Anxiety (HP:0000739)2.83780741
30Supranuclear gaze palsy (HP:0000605)2.70404702
31Postural instability (HP:0002172)2.69927639
32Peripheral hypomyelination (HP:0007182)2.68820087
33Impaired social interactions (HP:0000735)2.62948011
34Abnormal social behavior (HP:0012433)2.62948011
35Abnormality of binocular vision (HP:0011514)2.61378087
36Diplopia (HP:0000651)2.61378087
37Sudden death (HP:0001699)2.61237141
38Syncope (HP:0001279)2.59542522
39Dysmetria (HP:0001310)2.58754357
40Urinary bladder sphincter dysfunction (HP:0002839)2.58475656
41Amblyopia (HP:0000646)2.54339830
42Impaired smooth pursuit (HP:0007772)2.52704245
43Hemiplegia (HP:0002301)2.52501966
44Genetic anticipation (HP:0003743)2.46722742
45Akinesia (HP:0002304)2.46043298
46Sleep apnea (HP:0010535)2.43244229
47Epileptiform EEG discharges (HP:0011182)2.42968073
48Atrial fibrillation (HP:0005110)2.42022435
49Heart block (HP:0012722)2.41034967
50Primary atrial arrhythmia (HP:0001692)2.34340653
51Cerebral hypomyelination (HP:0006808)2.33118460
52Neurofibrillary tangles (HP:0002185)2.31388861
53Stereotypic behavior (HP:0000733)2.31034275
54Torticollis (HP:0000473)2.30982174
55EEG with generalized epileptiform discharges (HP:0011198)2.30151930
56Abnormality of the corticospinal tract (HP:0002492)2.29898608
57Split foot (HP:0001839)2.29225138
58Status epilepticus (HP:0002133)2.29094688
59Tetraplegia (HP:0002445)2.28762366
60Urinary urgency (HP:0000012)2.26445972
61Turricephaly (HP:0000262)2.26150265
62Drooling (HP:0002307)2.25513153
63Excessive salivation (HP:0003781)2.25513153
64Supraventricular tachycardia (HP:0004755)2.25349484
65Annular pancreas (HP:0001734)2.23214170
66Abnormality of the lower motor neuron (HP:0002366)2.23176518
67Alacrima (HP:0000522)2.22274297
68Scanning speech (HP:0002168)2.21254506
69Hypsarrhythmia (HP:0002521)2.20834708
70Supraventricular arrhythmia (HP:0005115)2.18414256
71Abnormal atrioventricular conduction (HP:0005150)2.16555562
72Dysmetric saccades (HP:0000641)2.15727194
73Abnormality of ocular smooth pursuit (HP:0000617)2.14290316
74Bradykinesia (HP:0002067)2.14207926
75Cerebral inclusion bodies (HP:0100314)2.12705157
76Fetal akinesia sequence (HP:0001989)2.10350912
77Hyporeflexia of lower limbs (HP:0002600)2.09885616
78Focal dystonia (HP:0004373)2.08903765
79Papilledema (HP:0001085)2.08727895
80Neuronal loss in central nervous system (HP:0002529)2.08237239
81Impaired vibratory sensation (HP:0002495)2.05427202
82Obstructive sleep apnea (HP:0002870)2.03670929
83Lower limb muscle weakness (HP:0007340)2.02972431
84Spastic gait (HP:0002064)2.01210956
85Polyphagia (HP:0002591)1.99438003
86Pheochromocytoma (HP:0002666)1.99333151
87Clonus (HP:0002169)1.98971427
88Intention tremor (HP:0002080)1.98732155
89Bronchomalacia (HP:0002780)1.96719016
90Morphological abnormality of the inner ear (HP:0011390)1.94262936
91Pointed chin (HP:0000307)1.93837724
92Ventricular fibrillation (HP:0001663)1.93374486
93Apathy (HP:0000741)1.92340939
94Partial duplication of thumb phalanx (HP:0009944)1.89873050
95Mutism (HP:0002300)1.88716244
96Narrow nasal bridge (HP:0000446)1.87652881
97Prolonged QT interval (HP:0001657)1.86146240
98Double outlet right ventricle (HP:0001719)1.85939759
99Congenital malformation of the right heart (HP:0011723)1.85939759
100Overriding aorta (HP:0002623)1.84927794
101Increased circulating renin level (HP:0000848)1.84209875
102Long nose (HP:0003189)1.82442405
103Craniofacial dystonia (HP:0012179)1.82249246
104Gait imbalance (HP:0002141)1.79498192
105Abnormal EKG (HP:0003115)1.78757330
106Specific learning disability (HP:0001328)1.77679413
107Insomnia (HP:0100785)1.75855637
108Incomplete penetrance (HP:0003829)1.75525040
109Gait ataxia (HP:0002066)1.72693426
110Blue irides (HP:0000635)1.72568611
111Limb dystonia (HP:0002451)1.72419572
112Hypoplastic left heart (HP:0004383)1.67722741
113Clumsiness (HP:0002312)1.67622876
114Broad alveolar ridges (HP:0000187)1.67316427
115Absent speech (HP:0001344)1.67197605
116Ankyloglossia (HP:0010296)1.64650159
117Inability to walk (HP:0002540)1.63991019
118Protruding tongue (HP:0010808)1.62921486
119Progressive inability to walk (HP:0002505)1.62746650
120Severe global developmental delay (HP:0011344)1.62129831
121Athetosis (HP:0002305)1.61120944
122Generalized myoclonic seizures (HP:0002123)1.60969260
123Lower limb asymmetry (HP:0100559)1.60619427
124Atrioventricular block (HP:0001678)1.58795736
125Rigidity (HP:0002063)1.58583083
126Palpebral edema (HP:0100540)1.58170991
127Mixed hearing impairment (HP:0000410)1.58076623
128Resting tremor (HP:0002322)1.57973574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.42684963
2NTRK34.07578087
3MAP3K93.27866998
4NTRK22.75889615
5MARK12.64100644
6MAP3K42.62855518
7DAPK22.61465107
8MAP2K72.46911101
9MINK12.39493410
10PRKD32.37646952
11TNIK2.29260362
12CASK2.24540121
13KSR21.82844709
14PAK61.82322263
15NTRK11.72551441
16PRPF4B1.67572822
17RIPK41.67417664
18CAMKK11.63484236
19DAPK11.60543169
20PHKG11.60201295
21PHKG21.60201295
22KSR11.59552577
23MAPK131.56224678
24LMTK21.55724573
25CDK51.46096756
26MAP2K41.39632765
27SGK21.37698142
28SGK4941.36275080
29SGK2231.36275080
30PRKCG1.36134950
31MAP3K21.28542309
32STK381.26683719
33PLK21.24670161
34MAP3K121.23389104
35SIK21.22474267
36MUSK1.11576567
37SGK31.11179084
38CDK191.09775830
39WNK31.07297665
40PKN11.06482712
41TYRO31.05331884
42PNCK1.02850802
43BMPR20.98544704
44UHMK10.98139040
45CAMKK20.95136230
46PDK20.93015116
47GRK50.92158673
48CAMK2A0.91499617
49NEK60.89406112
50CDK180.88774553
51FES0.88614622
52CDK150.86365143
53CCNB10.86024531
54OXSR10.82353886
55PINK10.81915135
56ROCK20.81174813
57SGK10.80851189
58CDK140.80318166
59STK110.78901222
60ICK0.78638705
61CAMK2B0.78129625
62DMPK0.77864783
63CDK11A0.75015912
64DYRK1A0.72069986
65MAPK120.71330052
66ARAF0.71119455
67MAP3K130.70790999
68PRKCH0.70747397
69CAMK10.69874925
70TAOK10.67724348
71RET0.64307548
72PAK30.61222161
73FGFR20.61092225
74PRKCE0.61078099
75LATS20.60823871
76RIPK10.59986041
77ROCK10.57676194
78LIMK10.57063209
79PTK2B0.55701557
80AKT30.54692449
81ERBB30.54438600
82WNK10.52844880
83FGR0.52749073
84MARK20.52617612
85RAF10.52345289
86SIK30.51978115
87CSNK1G20.51509949
88MAPK70.49835799
89PDPK10.49136958
90CAMK2D0.48383281
91BRAF0.48016124
92RPS6KA30.47967649
93CAMK2G0.47189054
94PRKCZ0.45803726
95NEK10.45741627
96PDK10.45720835
97EPHA30.45337329
98CDC42BPA0.42995647
99FER0.42367664
100WNK40.42310794
101MAPK100.41011519
102ALK0.40514464
103PRKD10.40073361
104MAP2K10.39907648
105CAMK1D0.39376338
106CAMK1G0.38540590
107BRSK10.37777636
108ERBB20.37772139
109PRKG10.36387719
110DYRK20.36208526
111AKT20.36143518
112PRKACA0.35645346
113TRIB30.35209572
114TNK20.34860832
115CAMK40.34810409
116FYN0.34367322
117CSNK1E0.32626224
118MAPKAPK50.32612821
119PRKCB0.32587065
120CSNK1D0.32548566
121DAPK30.30609822
122PRKCA0.30561154

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48162477
2Olfactory transduction_Homo sapiens_hsa047403.01793736
3Synaptic vesicle cycle_Homo sapiens_hsa047212.98707417
4Circadian entrainment_Homo sapiens_hsa047132.71422017
5Glutamatergic synapse_Homo sapiens_hsa047242.66064127
6GABAergic synapse_Homo sapiens_hsa047272.61948590
7Long-term potentiation_Homo sapiens_hsa047202.56096081
8Morphine addiction_Homo sapiens_hsa050322.52809929
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50353095
10Nitrogen metabolism_Homo sapiens_hsa009102.44120921
11Amphetamine addiction_Homo sapiens_hsa050312.40653133
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30024392
13Salivary secretion_Homo sapiens_hsa049702.23016532
14Insulin secretion_Homo sapiens_hsa049112.16439290
15Dopaminergic synapse_Homo sapiens_hsa047282.10272024
16Gastric acid secretion_Homo sapiens_hsa049712.03491254
17Cholinergic synapse_Homo sapiens_hsa047251.86774929
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82165840
19Cocaine addiction_Homo sapiens_hsa050301.81103761
20Vitamin B6 metabolism_Homo sapiens_hsa007501.72996895
21Taste transduction_Homo sapiens_hsa047421.71877407
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70132358
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65752397
24Renin secretion_Homo sapiens_hsa049241.63101584
25Calcium signaling pathway_Homo sapiens_hsa040201.58119301
26Serotonergic synapse_Homo sapiens_hsa047261.57968571
27Long-term depression_Homo sapiens_hsa047301.56267742
28Oxytocin signaling pathway_Homo sapiens_hsa049211.51315976
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44551463
30Gap junction_Homo sapiens_hsa045401.42176151
31GnRH signaling pathway_Homo sapiens_hsa049121.33492055
32cAMP signaling pathway_Homo sapiens_hsa040241.32221309
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28116905
34Collecting duct acid secretion_Homo sapiens_hsa049661.22700776
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16844298
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15380724
37Melanogenesis_Homo sapiens_hsa049161.11219171
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09337659
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06341604
40Axon guidance_Homo sapiens_hsa043601.04821996
41Glioma_Homo sapiens_hsa052141.03524613
42Estrogen signaling pathway_Homo sapiens_hsa049151.02609580
43Fatty acid biosynthesis_Homo sapiens_hsa000611.02436042
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01252752
45Type II diabetes mellitus_Homo sapiens_hsa049300.94541540
46ErbB signaling pathway_Homo sapiens_hsa040120.93167051
47Cardiac muscle contraction_Homo sapiens_hsa042600.91585344
48Pancreatic secretion_Homo sapiens_hsa049720.90852263
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.90834411
50Ovarian steroidogenesis_Homo sapiens_hsa049130.90328486
51Thyroid hormone synthesis_Homo sapiens_hsa049180.87034142
52Phototransduction_Homo sapiens_hsa047440.84834806
53Dorso-ventral axis formation_Homo sapiens_hsa043200.84752256
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83006842
55Circadian rhythm_Homo sapiens_hsa047100.80790813
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.79884257
57Arginine biosynthesis_Homo sapiens_hsa002200.76486866
58Choline metabolism in cancer_Homo sapiens_hsa052310.75512169
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75157191
60Oocyte meiosis_Homo sapiens_hsa041140.74989699
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73523118
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73164995
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71143934
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69537658
65Glucagon signaling pathway_Homo sapiens_hsa049220.69515231
66Arginine and proline metabolism_Homo sapiens_hsa003300.69486429
67Dilated cardiomyopathy_Homo sapiens_hsa054140.68328509
68Bile secretion_Homo sapiens_hsa049760.67478576
69Vibrio cholerae infection_Homo sapiens_hsa051100.66534353
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65050408
71Rap1 signaling pathway_Homo sapiens_hsa040150.62059787
72MAPK signaling pathway_Homo sapiens_hsa040100.61758004
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59678556
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59355477
75Hippo signaling pathway_Homo sapiens_hsa043900.58482265
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.57404143
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56116759
78Inositol phosphate metabolism_Homo sapiens_hsa005620.55947256
79Alcoholism_Homo sapiens_hsa050340.55604256
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.54149777
81Ras signaling pathway_Homo sapiens_hsa040140.54040824
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53458470
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53313339
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51401528
85Wnt signaling pathway_Homo sapiens_hsa043100.49389960
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47223827
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47107268
88mTOR signaling pathway_Homo sapiens_hsa041500.47077031
89Histidine metabolism_Homo sapiens_hsa003400.46763167
90Endometrial cancer_Homo sapiens_hsa052130.45904946
91Mineral absorption_Homo sapiens_hsa049780.45454274
92beta-Alanine metabolism_Homo sapiens_hsa004100.44586745
93Tight junction_Homo sapiens_hsa045300.43451474
94Type I diabetes mellitus_Homo sapiens_hsa049400.41592392
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41189833
96African trypanosomiasis_Homo sapiens_hsa051430.40954075
97Insulin signaling pathway_Homo sapiens_hsa049100.38985010
98VEGF signaling pathway_Homo sapiens_hsa043700.38614814
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.35076087
100AMPK signaling pathway_Homo sapiens_hsa041520.33522119
101Non-small cell lung cancer_Homo sapiens_hsa052230.33500585
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32291674
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32254313
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29896648
105Endocytosis_Homo sapiens_hsa041440.29094508
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26885604
107Prion diseases_Homo sapiens_hsa050200.26110333
108Renal cell carcinoma_Homo sapiens_hsa052110.24929914
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24346184
110Colorectal cancer_Homo sapiens_hsa052100.23595978
111Hedgehog signaling pathway_Homo sapiens_hsa043400.22321206
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21931097

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »