MAPK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.57998760
2nuclear pore organization (GO:0006999)5.27120587
3mitotic sister chromatid cohesion (GO:0007064)4.47547635
4heterochromatin organization (GO:0070828)4.35418230
5pore complex assembly (GO:0046931)4.06325711
6pre-miRNA processing (GO:0031054)4.01638440
7establishment of integrated proviral latency (GO:0075713)3.98294280
8regulation of RNA export from nucleus (GO:0046831)3.98168288
9NLS-bearing protein import into nucleus (GO:0006607)3.89319882
10monoubiquitinated protein deubiquitination (GO:0035520)3.68068059
11mitotic nuclear envelope disassembly (GO:0007077)3.65477290
12ribosome assembly (GO:0042255)3.62602908
13nuclear envelope disassembly (GO:0051081)3.54874233
14membrane disassembly (GO:0030397)3.54874233
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52657215
16protein localization to kinetochore (GO:0034501)3.52237140
17protein localization to chromosome, centromeric region (GO:0071459)3.42718457
18protein complex localization (GO:0031503)3.42356971
19dosage compensation (GO:0007549)3.39580453
20regulation of centriole replication (GO:0046599)3.32639261
21regulation of helicase activity (GO:0051095)3.31919372
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28382209
23regulation of nucleobase-containing compound transport (GO:0032239)3.27234168
24hippo signaling (GO:0035329)3.26057399
25mRNA stabilization (GO:0048255)3.22848861
26RNA stabilization (GO:0043489)3.22848861
27DNA unwinding involved in DNA replication (GO:0006268)3.21152044
28paraxial mesoderm development (GO:0048339)3.20507463
29cellular protein complex localization (GO:0034629)3.18333241
30regulation of sister chromatid cohesion (GO:0007063)3.16534162
31negative regulation of DNA repair (GO:0045738)3.15935960
32COPII vesicle coating (GO:0048208)3.11086894
33regulation of spindle organization (GO:0090224)3.09721604
34gene silencing by RNA (GO:0031047)3.05370908
35histone H2A monoubiquitination (GO:0035518)3.04631068
36non-recombinational repair (GO:0000726)3.02586507
37double-strand break repair via nonhomologous end joining (GO:0006303)3.02586507
38mitotic chromosome condensation (GO:0007076)3.02028717
39CENP-A containing nucleosome assembly (GO:0034080)3.01181475
40regulation of NFAT protein import into nucleus (GO:0051532)3.00964977
41establishment of chromosome localization (GO:0051303)3.00392217
42spindle checkpoint (GO:0031577)2.98413487
43sister chromatid segregation (GO:0000819)2.98343966
44L-serine metabolic process (GO:0006563)2.96893034
45chromatin remodeling at centromere (GO:0031055)2.96218971
46chromosome condensation (GO:0030261)2.95225535
47cell adhesion mediated by integrin (GO:0033627)2.94171197
48mitotic metaphase plate congression (GO:0007080)2.94105700
49nuclear envelope organization (GO:0006998)2.92597089
50regulation of hippo signaling (GO:0035330)2.91804385
51negative regulation of histone methylation (GO:0031061)2.91116919
52mitotic spindle checkpoint (GO:0071174)2.90708225
53DNA replication-dependent nucleosome assembly (GO:0006335)2.90533282
54DNA replication-dependent nucleosome organization (GO:0034723)2.90533282
55IMP biosynthetic process (GO:0006188)2.90313042
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86995659
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86995659
58positive regulation of mitotic sister chromatid separation (GO:1901970)2.86995659
59regulation of translational fidelity (GO:0006450)2.86529979
60synaptonemal complex assembly (GO:0007130)2.86178439
61chromatin assembly (GO:0031497)2.85591033
62anterior/posterior axis specification, embryo (GO:0008595)2.79131195
63positive regulation of chromosome segregation (GO:0051984)2.78210099
64cytoplasmic mRNA processing body assembly (GO:0033962)2.77934517
65IMP metabolic process (GO:0046040)2.77074850
66regulation of centrosome cycle (GO:0046605)2.74798794
67regulation of translational termination (GO:0006449)2.74779097
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74605289
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74605289
70negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74605289
71negative regulation of mitotic sister chromatid separation (GO:2000816)2.74605289
72negative regulation of sister chromatid segregation (GO:0033046)2.74605289
73histone exchange (GO:0043486)2.74384288
74regulation of chromatin binding (GO:0035561)2.72982124
75ATP-dependent chromatin remodeling (GO:0043044)2.70921208
76response to X-ray (GO:0010165)2.70813231
77DNA replication-independent nucleosome organization (GO:0034724)2.66972904
78DNA replication-independent nucleosome assembly (GO:0006336)2.66972904
79protein localization to chromosome (GO:0034502)2.66887209
80glucocorticoid receptor signaling pathway (GO:0042921)2.64849367
81telomere maintenance via telomerase (GO:0007004)2.64817588
82peptidyl-lysine dimethylation (GO:0018027)2.64552483
83DNA packaging (GO:0006323)2.64130696
84regulation of chromosome segregation (GO:0051983)2.63769623
85establishment of viral latency (GO:0019043)2.62096219
86mitotic G2/M transition checkpoint (GO:0044818)2.62077510
87gene silencing (GO:0016458)2.60513695
88regulation of sister chromatid segregation (GO:0033045)2.60467820
89regulation of mitotic sister chromatid separation (GO:0010965)2.60467820
90regulation of mitotic sister chromatid segregation (GO:0033047)2.60467820
91DNA topological change (GO:0006265)2.59092964
92positive regulation of cell cycle checkpoint (GO:1901978)2.58907861
93regulation of mitotic spindle organization (GO:0060236)2.58633826
94RNA-dependent DNA replication (GO:0006278)2.57850884
95regulation of mRNA stability (GO:0043488)2.57801800
96nucleotide-sugar biosynthetic process (GO:0009226)2.57769096
97mitotic sister chromatid segregation (GO:0000070)2.56971582
98negative regulation of DNA recombination (GO:0045910)2.56642964
99bundle of His cell to Purkinje myocyte communication (GO:0086069)2.56637848
100gap junction assembly (GO:0016264)2.56326347
101spindle assembly involved in mitosis (GO:0090307)2.55955289
102negative regulation of keratinocyte proliferation (GO:0010839)2.55607132
103positive regulation of SMAD protein import into nucleus (GO:0060391)2.55099746
104DNA double-strand break processing (GO:0000729)2.54132314
105binding of sperm to zona pellucida (GO:0007339)2.52129716
106DNA replication checkpoint (GO:0000076)2.51940273
107microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.51468873
108translesion synthesis (GO:0019985)2.51354863
109mitotic spindle assembly checkpoint (GO:0007094)2.50877100
110synaptonemal complex organization (GO:0070193)2.50615229
111regulation of RNA stability (GO:0043487)2.50322003
112protein-DNA complex disassembly (GO:0032986)2.49525818
113nucleosome disassembly (GO:0006337)2.49525818
114regulation of SMAD protein import into nucleus (GO:0060390)2.49252622
115DNA ligation (GO:0006266)2.48917629
116regulation of histone H3-K9 methylation (GO:0051570)2.48010627
117metaphase plate congression (GO:0051310)2.46515796
118spindle assembly checkpoint (GO:0071173)2.46184656
119DNA duplex unwinding (GO:0032508)2.45722660
120protein export from nucleus (GO:0006611)2.45524639
121microtubule depolymerization (GO:0007019)2.44850906
122DNA geometric change (GO:0032392)2.43885068
123female gonad development (GO:0008585)2.43520919
124spliceosomal tri-snRNP complex assembly (GO:0000244)2.43039948
125COPI coating of Golgi vesicle (GO:0048205)2.42785774
126Golgi transport vesicle coating (GO:0048200)2.42785774
127mitotic cytokinesis (GO:0000281)2.42437312
128somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.41831432
129isotype switching (GO:0045190)2.41831432
130somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41831432
131sperm-egg recognition (GO:0035036)2.40873162
132response to UV-C (GO:0010225)2.40198357
133corticosteroid receptor signaling pathway (GO:0031958)2.39665708
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.38569936
135intestinal epithelial cell development (GO:0060576)2.38378882
136tRNA aminoacylation for protein translation (GO:0006418)2.37440832
137cell fate commitment involved in formation of primary germ layer (GO:0060795)2.36989654
138embryonic foregut morphogenesis (GO:0048617)2.36633821
139piRNA metabolic process (GO:0034587)2.35674209
140somatic recombination of immunoglobulin gene segments (GO:0016447)2.33869395
141formation of translation preinitiation complex (GO:0001731)2.33616562
142regulation of centrosome duplication (GO:0010824)2.33292433
143sister chromatid cohesion (GO:0007062)2.33216075
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.33181977
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.33181977
146mRNA transport (GO:0051028)2.32824270
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.32710964
148male meiosis (GO:0007140)2.31514865
149DNA conformation change (GO:0071103)2.30564649
150gastrulation with mouth forming second (GO:0001702)2.29058778
151nucleus organization (GO:0006997)2.27910688
152chaperone-mediated protein complex assembly (GO:0051131)2.27873489
153cytoskeleton-dependent cytokinesis (GO:0061640)2.27744732
154fusion of sperm to egg plasma membrane (GO:0007342)2.27271827
155negative regulation of chromosome segregation (GO:0051985)2.27085507
156negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.25140447
157chromatin assembly or disassembly (GO:0006333)2.25095988
158nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.24747455
159negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.24205054
160polarized epithelial cell differentiation (GO:0030859)2.23787342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.87981442
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.63437534
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.63402264
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.25392219
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.94629256
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.40907309
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.18600268
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.98967374
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84346572
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60735970
11* AR_21909140_ChIP-Seq_LNCAP_Human2.55069540
12MYC_22102868_ChIP-Seq_BL_Human2.45435184
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.33132281
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00457631
15CLOCK_20551151_ChIP-Seq_293T_Human1.99220819
16WT1_19549856_ChIP-ChIP_CCG9911_Human1.98694634
17ELK1_19687146_ChIP-ChIP_HELA_Human1.95610328
18* E2F1_21310950_ChIP-Seq_MCF-7_Human1.92595080
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91667898
20* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.89337435
21PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88023640
22* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86678769
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86026067
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82275712
25* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.78935749
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76107420
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75765919
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73376422
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72224585
30* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71445172
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67717338
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67717338
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67717338
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67364460
35* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65167704
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64687200
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63940405
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.58990495
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.58308388
40ATF3_27146783_Chip-Seq_COLON_Human1.57359438
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56888451
42ZNF263_19887448_ChIP-Seq_K562_Human1.55684398
43* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54679361
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50995741
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50314416
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49795230
47PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48780235
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48444118
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.47963895
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46294867
51* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44361540
52* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43994018
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43844403
54* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43331204
55KDM2B_26808549_Chip-Seq_DND41_Human1.42503922
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42397523
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41729720
58FUS_26573619_Chip-Seq_HEK293_Human1.41285869
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40406249
60* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40376742
61* BRD4_25478319_ChIP-Seq_HGPS_Human1.39071899
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37923646
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37629596
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33734118
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33618977
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32401813
67EWS_26573619_Chip-Seq_HEK293_Human1.32379984
68* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32200909
69* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32200909
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31417001
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30993915
72* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27361121
73TAF15_26573619_Chip-Seq_HEK293_Human1.26982567
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25694013
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.24727092
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24208406
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.23987574
78UBF1/2_26484160_Chip-Seq_HMECs_Human1.23525462
79* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23068577
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21868138
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.21280789
82* CHD1_26751641_Chip-Seq_LNCaP_Human1.21150654
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.21021830
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20390888
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20301004
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19344299
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19271954
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18497949
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17818643
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17235408
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16815371
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16522685
93TP53_22127205_ChIP-Seq_IMR90_Human1.15851161
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14437153
95KDM5A_27292631_Chip-Seq_BREAST_Human1.12350631
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10354261
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07626011
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07246594
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06550015
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.06303427
101TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05610213
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05234578
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04379828
104* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02561704
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02320147
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01888556
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.01359332
108DCP1A_22483619_ChIP-Seq_HELA_Human1.01287659
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01223271
110* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00959746
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00728474
112* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00024523
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99311684
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.99009003
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99003382
116GABP_17652178_ChIP-ChIP_JURKAT_Human0.98864481
117P300_19829295_ChIP-Seq_ESCs_Human0.98729375
118NCOR1_26117541_ChIP-Seq_K562_Human0.98439557
119POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98385919
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98093968
121* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97965213
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97298865
123* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97280612
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96487021
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96400453
126GATA6_25053715_ChIP-Seq_YYC3_Human0.96260232
127MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96061390
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95646258
129XRN2_22483619_ChIP-Seq_HELA_Human0.94822677
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94625164
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93952546
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93751999
133TFEB_21752829_ChIP-Seq_HELA_Human0.93475922
134UTX_26944678_Chip-Seq_JUKART_Human0.93048735
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92161878
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92135235
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91545567
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91520907
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.91152155
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91116218
141* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90951531
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90059618
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89295095
144* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89058528
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88784269
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88561776
147FLI1_27457419_Chip-Seq_LIVER_Mouse0.88499854
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87792902
149TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86705705
150TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86393122
151HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85687398
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82554605
153HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82512716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.78379005
2MP0003705_abnormal_hypodermis_morpholog3.53166496
3MP0005076_abnormal_cell_differentiation3.32762815
4MP0010352_gastrointestinal_tract_polyps3.23640720
5MP0000569_abnormal_digit_pigmentation2.82779629
6MP0002796_impaired_skin_barrier2.61197435
7MP0000537_abnormal_urethra_morphology2.32551041
8MP0010030_abnormal_orbit_morphology2.28958767
9MP0003111_abnormal_nucleus_morphology2.28076875
10MP0009053_abnormal_anal_canal2.21243151
11MP0000579_abnormal_nail_morphology2.19988131
12MP0010307_abnormal_tumor_latency2.14694800
13MP0000733_abnormal_muscle_development2.08823373
14MP0003077_abnormal_cell_cycle2.06688665
15MP0003693_abnormal_embryo_hatching2.01281071
16MP0004264_abnormal_extraembryonic_tissu2.01235543
17MP0009697_abnormal_copulation2.00457013
18MP0010094_abnormal_chromosome_stability1.97119661
19MP0002653_abnormal_ependyma_morphology1.93144796
20MP0001730_embryonic_growth_arrest1.90671790
21MP0008438_abnormal_cutaneous_collagen1.88825486
22MP0005623_abnormal_meninges_morphology1.83774177
23MP0001849_ear_inflammation1.81063584
24MP0008007_abnormal_cellular_replicative1.79596574
25MP0000350_abnormal_cell_proliferation1.77635622
26MP0003718_maternal_effect1.76411977
27MP0004957_abnormal_blastocyst_morpholog1.74431038
28MP0005410_abnormal_fertilization1.71807154
29MP0003122_maternal_imprinting1.70677541
30MP0005501_abnormal_skin_physiology1.68294972
31MP0002084_abnormal_developmental_patter1.67982774
32* MP0004197_abnormal_fetal_growth/weight/1.67439249
33MP0003566_abnormal_cell_adhesion1.67162637
34MP0005380_embryogenesis_phenotype1.65812365
35MP0001672_abnormal_embryogenesis/_devel1.65812365
36MP0003123_paternal_imprinting1.60650534
37MP0003984_embryonic_growth_retardation1.60361767
38MP0002088_abnormal_embryonic_growth/wei1.59301401
39MP0003890_abnormal_embryonic-extraembry1.57713188
40MP0010234_abnormal_vibrissa_follicle1.54602132
41MP0002085_abnormal_embryonic_tissue1.53226088
42MP0003221_abnormal_cardiomyocyte_apopto1.53087630
43MP0001697_abnormal_embryo_size1.48732183
44MP0005257_abnormal_intraocular_pressure1.47536388
45MP0002086_abnormal_extraembryonic_tissu1.42427513
46MP0003091_abnormal_cell_migration1.42008857
47MP0008877_abnormal_DNA_methylation1.41361037
48MP0005023_abnormal_wound_healing1.39980270
49MP0009278_abnormal_bone_marrow1.38545479
50MP0005248_abnormal_Harderian_gland1.35357283
51MP0000428_abnormal_craniofacial_morphol1.33545364
52MP0005275_abnormal_skin_tensile1.33275799
53MP0003303_peritoneal_inflammation1.33121604
54MP0002282_abnormal_trachea_morphology1.30275684
55* MP0003115_abnormal_respiratory_system1.28781340
56MP0000647_abnormal_sebaceous_gland1.28336400
57MP0003937_abnormal_limbs/digits/tail_de1.28288267
58MP0003300_gastrointestinal_ulcer1.27555985
59MP0008057_abnormal_DNA_replication1.26845857
60MP0002233_abnormal_nose_morphology1.26584500
61MP0001293_anophthalmia1.25010451
62MP0003121_genomic_imprinting1.24373528
63MP0001666_abnormal_nutrient_absorption1.23888160
64MP0003315_abnormal_perineum_morphology1.22299624
65MP0000566_synostosis1.21589710
66MP0002080_prenatal_lethality1.21397438
67MP0008932_abnormal_embryonic_tissue1.21020628
68MP0002877_abnormal_melanocyte_morpholog1.20125640
69MP0002092_abnormal_eye_morphology1.18819032
70MP0001915_intracranial_hemorrhage1.17688730
71MP0004808_abnormal_hematopoietic_stem1.17127334
72MP0003119_abnormal_digestive_system1.17067607
73MP0003385_abnormal_body_wall1.15570468
74MP0002254_reproductive_system_inflammat1.15373564
75MP0000432_abnormal_head_morphology1.12212337
76MP0003935_abnormal_craniofacial_develop1.11445562
77MP0004233_abnormal_muscle_weight1.10450346
78MP0001216_abnormal_epidermal_layer1.09390100
79MP0003950_abnormal_plasma_membrane1.09354678
80MP0000762_abnormal_tongue_morphology1.07989486
81MP0002210_abnormal_sex_determination1.06127986
82MP0002697_abnormal_eye_size1.06105854
83MP0004185_abnormal_adipocyte_glucose1.05742918
84MP0001929_abnormal_gametogenesis1.05463700
85MP0001188_hyperpigmentation1.04900892
86MP0005499_abnormal_olfactory_system1.04604406
87MP0005394_taste/olfaction_phenotype1.04604406
88MP0001299_abnormal_eye_distance/1.04388597
89MP0003755_abnormal_palate_morphology1.03723649
90MP0003448_altered_tumor_morphology1.03013773
91MP0003868_abnormal_feces_composition1.01754459
92MP0002925_abnormal_cardiovascular_devel1.00158553
93MP0004782_abnormal_surfactant_physiolog0.98091375
94MP0002234_abnormal_pharynx_morphology0.98088826
95MP0002139_abnormal_hepatobiliary_system0.95607751
96MP0000377_abnormal_hair_follicle0.95394719
97MP0002098_abnormal_vibrissa_morphology0.93395748
98MP0003942_abnormal_urinary_system0.93309249
99MP0003861_abnormal_nervous_system0.92861934
100MP0003567_abnormal_fetal_cardiomyocyte0.92772227
101MP0002111_abnormal_tail_morphology0.92645752
102MP0000534_abnormal_ureter_morphology0.91325049
103* MP0009672_abnormal_birth_weight0.91324389
104MP0008058_abnormal_DNA_repair0.91067644
105MP0005187_abnormal_penis_morphology0.90725397
106MP0003453_abnormal_keratinocyte_physiol0.89837927
107MP0000750_abnormal_muscle_regeneration0.89744993
108MP0010678_abnormal_skin_adnexa0.89474606
109MP0003698_abnormal_male_reproductive0.89031386
110MP0006054_spinal_hemorrhage0.88899264
111MP0005503_abnormal_tendon_morphology0.88473784
112MP0002089_abnormal_postnatal_growth/wei0.87209139
113MP0005508_abnormal_skeleton_morphology0.86820073
114MP0000383_abnormal_hair_follicle0.86747910
115MP0001145_abnormal_male_reproductive0.86670265
116MP0002060_abnormal_skin_morphology0.86102165
117MP0005621_abnormal_cell_physiology0.85749718
118* MP0009703_decreased_birth_body0.85733437
119MP0000467_abnormal_esophagus_morphology0.84731066
120MP0002932_abnormal_joint_morphology0.82846833
121MP0002116_abnormal_craniofacial_bone0.82408771
122MP0000627_abnormal_mammary_gland0.80978046
123* MP0002081_perinatal_lethality0.80704962
124MP0004272_abnormal_basement_membrane0.79452474
125MP0000490_abnormal_crypts_of0.77133640
126MP0008789_abnormal_olfactory_epithelium0.76593695
127MP0002009_preneoplasia0.76551410
128MP0004947_skin_inflammation0.74784374
129MP0001286_abnormal_eye_development0.74033124
130MP0001191_abnormal_skin_condition0.73984571
131MP0002751_abnormal_autonomic_nervous0.73624907
132MP0010771_integument_phenotype0.72905966
133MP0000653_abnormal_sex_gland0.72806483
134MP0000313_abnormal_cell_death0.72500321
135MP0005384_cellular_phenotype0.68537536
136MP0000778_abnormal_nervous_system0.66090551
137MP0005395_other_phenotype0.64459972
138MP0001340_abnormal_eyelid_morphology0.64356213

Predicted human phenotypes

RankGene SetZ-score
1Nephroblastoma (Wilms tumor) (HP:0002667)3.63097788
2Embryonal renal neoplasm (HP:0011794)3.51727991
3Chromsome breakage (HP:0040012)3.27589385
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26335756
5Short 4th metacarpal (HP:0010044)3.08275412
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.08275412
7Insidious onset (HP:0003587)3.05992318
8Termporal pattern (HP:0011008)3.05992318
9Abnormality of nail color (HP:0100643)3.03529399
10Shallow orbits (HP:0000586)2.94187379
11Thyroid carcinoma (HP:0002890)2.83415064
12Curly hair (HP:0002212)2.83398072
13Asymmetry of the thorax (HP:0001555)2.81501564
14Medulloblastoma (HP:0002885)2.75721229
15Hepatoblastoma (HP:0002884)2.70054304
16Rhabdomyosarcoma (HP:0002859)2.67673784
17Heterotopia (HP:0002282)2.62423101
18Protrusio acetabuli (HP:0003179)2.59988912
19Absent eyelashes (HP:0000561)2.50077807
20Multiple enchondromatosis (HP:0005701)2.50076974
21Increased density of long bones (HP:0006392)2.48794970
22Subacute progressive viral hepatitis (HP:0006572)2.44041485
23Premature rupture of membranes (HP:0001788)2.43959377
24Abnormal lung lobation (HP:0002101)2.42189109
25Spastic diplegia (HP:0001264)2.41717060
26Abnormality of the labia minora (HP:0012880)2.40573707
27Meckel diverticulum (HP:0002245)2.36386582
28Pelvic girdle muscle weakness (HP:0003749)2.36195209
29Hyperacusis (HP:0010780)2.35899726
30Cerebral aneurysm (HP:0004944)2.34826421
31Absent eyebrow (HP:0002223)2.32959814
32Ankle contracture (HP:0006466)2.31914221
33Abnormality of chromosome stability (HP:0003220)2.30957631
34Deviation of the thumb (HP:0009603)2.30229725
35Genu recurvatum (HP:0002816)2.29873666
36Shoulder girdle muscle weakness (HP:0003547)2.27493077
37Absent frontal sinuses (HP:0002688)2.27415300
38Wrist flexion contracture (HP:0001239)2.26271116
39Embryonal neoplasm (HP:0002898)2.25374008
40Increased nuchal translucency (HP:0010880)2.24293296
41Abnormality of the 4th metacarpal (HP:0010012)2.22457722
42Abnormality of the ileum (HP:0001549)2.21413737
43Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20185000
44Colon cancer (HP:0003003)2.19352229
45Abnormality of glycolysis (HP:0004366)2.19011980
46Breast carcinoma (HP:0003002)2.17652468
47Hypobetalipoproteinemia (HP:0003563)2.15750739
48Abnormality of the astrocytes (HP:0100707)2.14875898
49Astrocytoma (HP:0009592)2.14875898
50Myelomeningocele (HP:0002475)2.14522306
51Proximal placement of thumb (HP:0009623)2.14160248
52Hand muscle atrophy (HP:0009130)2.12977732
53Aplasia/Hypoplasia of the sternum (HP:0006714)2.12658499
54Pancreatic islet-cell hyperplasia (HP:0004510)2.12103726
55Selective tooth agenesis (HP:0001592)2.07243942
56Increased serum pyruvate (HP:0003542)2.06782037
57Gastrointestinal carcinoma (HP:0002672)2.06477591
58Malignant gastrointestinal tract tumors (HP:0006749)2.06477591
59Intrahepatic cholestasis (HP:0001406)2.05728656
60Abnormality of the calcaneus (HP:0008364)2.05230822
61Renal duplication (HP:0000075)2.02863008
62Spinal cord lesions (HP:0100561)2.01041300
63Syringomyelia (HP:0003396)2.01041300
64Ankyloglossia (HP:0010296)2.00557783
65Abnormality of the preputium (HP:0100587)1.99737014
66Rectal prolapse (HP:0002035)1.98928986
67Upper limb amyotrophy (HP:0009129)1.96112274
68Distal upper limb amyotrophy (HP:0007149)1.96112274
69Tetraparesis (HP:0002273)1.95843916
70Right ventricular cardiomyopathy (HP:0011663)1.95172442
71Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.94035870
72Short nail (HP:0001799)1.93127328
73Abnormality of the musculature of the pelvis (HP:0001469)1.91687740
74Abnormality of the hip-girdle musculature (HP:0001445)1.91687740
75Renovascular hypertension (HP:0100817)1.91227801
76Ectopic kidney (HP:0000086)1.90683432
77Absent hair (HP:0002298)1.90103043
78Volvulus (HP:0002580)1.88356864
79Osteolytic defects of the phalanges of the hand (HP:0009771)1.88163813
80Osteolytic defects of the hand bones (HP:0009699)1.88163813
81Abnormality of the salivary glands (HP:0010286)1.87994743
82Onycholysis (HP:0001806)1.87466900
83Dilatation of the ascending aorta (HP:0005111)1.86810126
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.86711145
85Deviation of the hallux (HP:0010051)1.86515250
86Choanal stenosis (HP:0000452)1.86096168
87Uterine leiomyosarcoma (HP:0002891)1.85883078
88Leiomyosarcoma (HP:0100243)1.85883078
89Hallux valgus (HP:0001822)1.85738061
90Blepharitis (HP:0000498)1.85375083
91Acanthocytosis (HP:0001927)1.84953743
92Thick nail (HP:0001805)1.84710925
93Oral leukoplakia (HP:0002745)1.83888402
94Bladder diverticulum (HP:0000015)1.83840270
95Duodenal stenosis (HP:0100867)1.83424703
96Small intestinal stenosis (HP:0012848)1.83424703
97Ependymoma (HP:0002888)1.83137967
98Overlapping toe (HP:0001845)1.81028038
99Male infertility (HP:0003251)1.80604839
100Papillary thyroid carcinoma (HP:0002895)1.80574505
101Abnormality of the lower motor neuron (HP:0002366)1.80438331
102Transitional cell carcinoma of the bladder (HP:0006740)1.80203281
103Labial hypoplasia (HP:0000066)1.79993445
104Disinhibition (HP:0000734)1.79670731
105Hypoplastic female external genitalia (HP:0012815)1.79163318
106Mitral valve prolapse (HP:0001634)1.78871826
107Degeneration of anterior horn cells (HP:0002398)1.78685975
108Abnormality of the anterior horn cell (HP:0006802)1.78685975
109Ulnar bowing (HP:0003031)1.77735837
110Agnosia (HP:0010524)1.77619699
111Pterygium (HP:0001059)1.76941949
112Renal cell carcinoma (HP:0005584)1.76781161
113Cervical subluxation (HP:0003308)1.76706365
114Cystic hygroma (HP:0000476)1.76483969
115Limited elbow extension (HP:0001377)1.76225576
116Septate vagina (HP:0001153)1.75504967
117Bowel diverticulosis (HP:0005222)1.74728595
118Neoplasm of the thyroid gland (HP:0100031)1.74063810
119Palmar hyperkeratosis (HP:0010765)1.73634841
120Broad alveolar ridges (HP:0000187)1.72788434
121Hypoplastic labia majora (HP:0000059)1.72065420
122Increased connective tissue (HP:0009025)1.71762911
123Broad thumb (HP:0011304)1.71361014
124Radial bowing (HP:0002986)1.70802356
125Trigonocephaly (HP:0000243)1.70462824
126Atrophic scars (HP:0001075)1.70217890
127Bladder carcinoma (HP:0002862)1.69427081
128Bladder neoplasm (HP:0009725)1.69427081
129Narrow palate (HP:0000189)1.68602579
130Microglossia (HP:0000171)1.68029628
131Ovarian neoplasm (HP:0100615)1.67922020
132Neoplasm of the small intestine (HP:0100833)1.67498770
133Elfin facies (HP:0004428)1.67243134
134Cortical dysplasia (HP:0002539)1.66998622
135Erythroderma (HP:0001019)1.66535067
136Neoplasm of striated muscle (HP:0009728)1.66456403
137Stenosis of the external auditory canal (HP:0000402)1.65645294
138Urinary urgency (HP:0000012)1.65150773
139Long eyelashes (HP:0000527)1.64658957
140Anal stenosis (HP:0002025)1.64509361
141Short humerus (HP:0005792)1.64237828
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.63835995
143Deep venous thrombosis (HP:0002625)1.63005931
144Absent radius (HP:0003974)1.63000883
145Upper limb muscle weakness (HP:0003484)1.62710527
146Abnormality of methionine metabolism (HP:0010901)1.61161842
147Deep philtrum (HP:0002002)1.61106942
148Abnormality of the duodenum (HP:0002246)1.60880929
149Biliary tract neoplasm (HP:0100574)1.60597296
150Urethral obstruction (HP:0000796)1.60287886
151Broad phalanges of the hand (HP:0009768)1.60202130
152Progressive external ophthalmoplegia (HP:0000590)1.59957446
153Carpal bone hypoplasia (HP:0001498)1.59563364
154Glioma (HP:0009733)1.59545670
155Birth length less than 3rd percentile (HP:0003561)1.59369997
156Metaphyseal cupping (HP:0003021)1.59093548
157Impulsivity (HP:0100710)1.58931471
158Amyotrophic lateral sclerosis (HP:0007354)1.58531461
159Difficulty climbing stairs (HP:0003551)1.58508771
160Aortic aneurysm (HP:0004942)1.58242859
161Cutis marmorata (HP:0000965)1.56288730
162Milia (HP:0001056)1.52865541
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.52117163
164Overriding aorta (HP:0002623)1.51904301
165Broad long bones (HP:0005622)1.50796004
166Uterine neoplasm (HP:0010784)1.50702962
167Broad phalanx (HP:0006009)1.50650325
168Cutaneous melanoma (HP:0012056)1.50380552
169Aortic dissection (HP:0002647)1.50036118
170Soft skin (HP:0000977)1.49939156
171Aplasia/hypoplasia of the humerus (HP:0006507)1.48623049
172Skull defect (HP:0001362)1.47987340
173High pitched voice (HP:0001620)1.47901782
174Oligodactyly (HP:0012165)1.47126256
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.46975661
176Exostoses (HP:0100777)1.46170297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.35005565
2CDK123.33981759
3TRIB32.81145039
4TRIM282.80954770
5CDC72.71441266
6EIF2AK32.71219073
7BCR2.58081848
8TESK12.57206084
9NEK22.43395441
10EPHA22.23659145
11PBK2.20158321
12EEF2K2.13381861
13LATS22.07729480
14RIPK11.97465533
15STK31.95651106
16PKN21.95553889
17ICK1.92966222
18MAP3K101.90570900
19TNIK1.89927448
20STK241.85093347
21MST41.81384102
22TAF11.74436837
23PASK1.68776847
24TTN1.68103909
25CASK1.64847168
26MAP3K41.64550278
27RPS6KA41.62698732
28PDGFRA1.59874675
29PAK41.52120916
30MTOR1.46581862
31DDR21.43415221
32PDK41.42323767
33PDK31.42323767
34PRKD31.41798776
35PTK61.40866263
36MAP3K91.38079497
37TTK1.36348208
38CDK61.31328371
39CAMK1D1.30306706
40SCYL21.28057691
41TESK21.22104458
42FGFR11.21280828
43WEE11.19849699
44ERBB31.18702808
45BMX1.18065471
46STK101.17813238
47EPHB21.16028396
48SIK31.14370922
49WNK31.13588663
50TYRO31.12497261
51CAMK1G1.12213701
52TAOK11.11822409
53ALK1.08274339
54BRD41.08256293
55CHEK11.06386546
56NEK11.05767501
57ATR1.05168923
58MKNK11.05087032
59PTK21.04064577
60STK38L1.03640412
61PLK31.02929168
62IRAK30.99576279
63KSR10.96322422
64PLK20.95902892
65MAP3K80.94768325
66PLK10.94087397
67PDGFRB0.92469882
68CDK40.91991383
69CHEK20.90693108
70EIF2AK20.90399480
71SIK10.90051499
72PLK40.87328109
73MAP3K120.83553527
74DYRK30.83205075
75AURKB0.81029718
76PDK20.80752045
77CDK70.79419070
78BUB10.79210028
79MAP2K70.76328244
80DYRK1B0.76226855
81ATM0.75729583
82CHUK0.75515434
83TSSK60.74552858
84PAK60.74534093
85LIMK10.73417269
86ZAK0.73132242
87DMPK0.73055268
88MELK0.72825794
89CDK20.72723871
90MARK10.72363289
91YES10.70667874
92AKT30.70538508
93TGFBR10.69914855
94BRSK20.67325441
95ERBB40.66659568
96CSNK1G10.66404620
97MAP3K30.65985025
98SRPK10.65313475
99ACVR1B0.65214668
100NEK60.65153043
101PIK3CA0.64021680
102ERBB20.59920770
103LRRK20.59861659
104RPS6KB20.59427345
105CDK180.59049217
106FGFR40.57402881
107MET0.55422864
108* CDK10.54043111
109MINK10.53752698
110CSNK1A1L0.53132677
111MKNK20.52910414
112NUAK10.52603365
113PNCK0.52486489
114FGFR30.52486449
115CDK90.51973465
116CAMKK10.51927254
117EIF2AK10.51255580
118* PAK20.50897834
119DYRK20.50005779
120CSNK1D0.49753464
121PAK10.49517318
122MAP3K50.49516444
123STK390.48983616
124CSNK1G20.48503047
125BRSK10.47818119
126CDK150.47243873
127CDK140.47166767
128STK380.43682073
129FER0.43269350
130RPS6KB10.42937672
131BMPR1B0.41961338
132FRK0.39607088
133CLK10.39357942
134RPS6KA10.39255382
135CSNK1G30.39133923
136ERN10.38604440
137CSNK1E0.38048876
138CDK11A0.37931771
139NTRK10.35869078
140BRAF0.33557985

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.97195611
2Non-homologous end-joining_Homo sapiens_hsa034502.75456495
3Cell cycle_Homo sapiens_hsa041102.27145101
4RNA transport_Homo sapiens_hsa030132.20183559
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08741667
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00525748
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97714434
8MicroRNAs in cancer_Homo sapiens_hsa052061.96546057
9Small cell lung cancer_Homo sapiens_hsa052221.83001479
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82849629
11Chronic myeloid leukemia_Homo sapiens_hsa052201.82177238
12mRNA surveillance pathway_Homo sapiens_hsa030151.78166928
13p53 signaling pathway_Homo sapiens_hsa041151.71886886
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69106562
15Hippo signaling pathway_Homo sapiens_hsa043901.67339980
16Adherens junction_Homo sapiens_hsa045201.61545271
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58229986
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57926837
19Vitamin B6 metabolism_Homo sapiens_hsa007501.55884132
20Biosynthesis of amino acids_Homo sapiens_hsa012301.51872021
21Proteoglycans in cancer_Homo sapiens_hsa052051.51039536
22Colorectal cancer_Homo sapiens_hsa052101.48010799
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47819465
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47707555
25mTOR signaling pathway_Homo sapiens_hsa041501.46529175
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.46210925
27Protein export_Homo sapiens_hsa030601.45086136
28Basal cell carcinoma_Homo sapiens_hsa052171.42515913
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42430117
30Viral carcinogenesis_Homo sapiens_hsa052031.39818067
31Viral myocarditis_Homo sapiens_hsa054161.38290451
32Spliceosome_Homo sapiens_hsa030401.36223996
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32651970
34TGF-beta signaling pathway_Homo sapiens_hsa043501.31911105
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31395309
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30522051
37Proteasome_Homo sapiens_hsa030501.30356464
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29084145
39HTLV-I infection_Homo sapiens_hsa051661.26448667
40Propanoate metabolism_Homo sapiens_hsa006401.26311903
41Endometrial cancer_Homo sapiens_hsa052131.25428846
42Pancreatic cancer_Homo sapiens_hsa052121.25363006
43Focal adhesion_Homo sapiens_hsa045101.23831572
44Oocyte meiosis_Homo sapiens_hsa041141.21341303
45DNA replication_Homo sapiens_hsa030301.19193085
46Bladder cancer_Homo sapiens_hsa052191.18798328
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.17889236
48Pyruvate metabolism_Homo sapiens_hsa006201.16740921
49Hedgehog signaling pathway_Homo sapiens_hsa043401.16349510
50ECM-receptor interaction_Homo sapiens_hsa045121.15436630
51Carbon metabolism_Homo sapiens_hsa012001.13345965
52Nucleotide excision repair_Homo sapiens_hsa034201.12060589
53Renal cell carcinoma_Homo sapiens_hsa052111.11274028
54Notch signaling pathway_Homo sapiens_hsa043301.10798298
55Shigellosis_Homo sapiens_hsa051311.10094083
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09215851
57Toxoplasmosis_Homo sapiens_hsa051451.07571320
58Legionellosis_Homo sapiens_hsa051341.06852278
59Dorso-ventral axis formation_Homo sapiens_hsa043201.05469726
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05201463
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05177398
62TNF signaling pathway_Homo sapiens_hsa046681.04948787
63Prostate cancer_Homo sapiens_hsa052151.03028855
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01875356
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01624171
66One carbon pool by folate_Homo sapiens_hsa006701.01502202
67Apoptosis_Homo sapiens_hsa042101.01109677
68Hepatitis B_Homo sapiens_hsa051611.00712849
69Epstein-Barr virus infection_Homo sapiens_hsa051691.00598738
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.98894325
71Fatty acid biosynthesis_Homo sapiens_hsa000610.94086418
72Vitamin digestion and absorption_Homo sapiens_hsa049770.92825177
73Antigen processing and presentation_Homo sapiens_hsa046120.91420491
74Glioma_Homo sapiens_hsa052140.91254669
75Tight junction_Homo sapiens_hsa045300.91090160
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90548778
77Non-small cell lung cancer_Homo sapiens_hsa052230.88247001
78Acute myeloid leukemia_Homo sapiens_hsa052210.87935372
79Herpes simplex infection_Homo sapiens_hsa051680.87855350
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87392915
81Fatty acid metabolism_Homo sapiens_hsa012120.87218403
82Thyroid cancer_Homo sapiens_hsa052160.86952915
83Amoebiasis_Homo sapiens_hsa051460.85562692
84Pathways in cancer_Homo sapiens_hsa052000.85097775
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84931361
86VEGF signaling pathway_Homo sapiens_hsa043700.84653421
87HIF-1 signaling pathway_Homo sapiens_hsa040660.84439836
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82621515
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81490411
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81424452
91Arginine biosynthesis_Homo sapiens_hsa002200.80695022
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.79878392
93FoxO signaling pathway_Homo sapiens_hsa040680.79678904
94Wnt signaling pathway_Homo sapiens_hsa043100.79603699
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79418794
96AMPK signaling pathway_Homo sapiens_hsa041520.79200449
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77072052
98Prolactin signaling pathway_Homo sapiens_hsa049170.74916133
99Fanconi anemia pathway_Homo sapiens_hsa034600.74502760
100Arginine and proline metabolism_Homo sapiens_hsa003300.74333411
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74325788
102Sphingolipid metabolism_Homo sapiens_hsa006000.73889408
103Influenza A_Homo sapiens_hsa051640.73519304
104Leishmaniasis_Homo sapiens_hsa051400.72567200
105Lysine degradation_Homo sapiens_hsa003100.72163531
106Mismatch repair_Homo sapiens_hsa034300.71817484
107Base excision repair_Homo sapiens_hsa034100.70712920
108RNA degradation_Homo sapiens_hsa030180.70545151
109Insulin resistance_Homo sapiens_hsa049310.69193269
110Salmonella infection_Homo sapiens_hsa051320.68917352
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.68600244
112Osteoclast differentiation_Homo sapiens_hsa043800.68528648
113Melanoma_Homo sapiens_hsa052180.68115537
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67016079
115ErbB signaling pathway_Homo sapiens_hsa040120.66826724
116Basal transcription factors_Homo sapiens_hsa030220.65890136
117Starch and sucrose metabolism_Homo sapiens_hsa005000.65517359
118T cell receptor signaling pathway_Homo sapiens_hsa046600.65158082
119Systemic lupus erythematosus_Homo sapiens_hsa053220.64946932
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64851197
121Estrogen signaling pathway_Homo sapiens_hsa049150.64655618
122Measles_Homo sapiens_hsa051620.64269916
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64058847
124Circadian rhythm_Homo sapiens_hsa047100.63857622
125Selenocompound metabolism_Homo sapiens_hsa004500.63073920
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62732877
127Endocytosis_Homo sapiens_hsa041440.62400966
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61519574
129Axon guidance_Homo sapiens_hsa043600.60115244
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59963097
131Malaria_Homo sapiens_hsa051440.58613621
132Fatty acid elongation_Homo sapiens_hsa000620.58161393
133Type II diabetes mellitus_Homo sapiens_hsa049300.58134595
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58106942
135Fat digestion and absorption_Homo sapiens_hsa049750.56792451
136Insulin signaling pathway_Homo sapiens_hsa049100.56224380
137N-Glycan biosynthesis_Homo sapiens_hsa005100.55774532
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48055839
139Galactose metabolism_Homo sapiens_hsa000520.47184074
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43858788
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42863920
142RNA polymerase_Homo sapiens_hsa030200.42795903
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42188236
144Gap junction_Homo sapiens_hsa045400.38665737
145Glutathione metabolism_Homo sapiens_hsa004800.38384111
146Renin-angiotensin system_Homo sapiens_hsa046140.37906096
147Homologous recombination_Homo sapiens_hsa034400.36530441
148Pentose phosphate pathway_Homo sapiens_hsa000300.35994777

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