ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	8.48567937
2	protein K11-linked deubiquitination (GO:0035871)	6.28473147
3	nuclear pore complex assembly (GO:0051292)	5.66068662
4	positive regulation of digestive system process (GO:0060456)	5.27074867
5	nuclear pore organization (GO:0006999)	5.08086257
6	negative regulation of smooth muscle cell differentiation (GO:0051151)	4.61427929
7	positive regulation of protein autophosphorylation (GO:0031954)	4.61014374
8	adaptation of signaling pathway (GO:0023058)	4.44966194
9	establishment of protein localization to Golgi (GO:0072600)	4.30605620
10	response to histamine (GO:0034776)	4.25712273
11	pore complex assembly (GO:0046931)	4.22581954
12	inner ear receptor cell development (GO:0060119)	4.21159003
13	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	4.05051617
14	nephron tubule formation (GO:0072079)	4.02927520
15	cochlea development (GO:0090102)	3.83039985
16	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.76059769
17	negative regulation of systemic arterial blood pressure (GO:0003085)	3.72097775
18	Rap protein signal transduction (GO:0032486)	3.69684092
19	protein targeting to Golgi (GO:0000042)	3.66291419
20	retinal cone cell development (GO:0046549)	3.64465438
21	keratinocyte development (GO:0003334)	3.60989933
22	neural tube formation (GO:0001841)	3.59485447
23	innervation (GO:0060384)	3.56414708
24	ncRNA 3-end processing (GO:0043628)	3.55563885
25	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.55324652
26	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.54353861
27	protein localization to microtubule cytoskeleton (GO:0072698)	3.49247942
28	regulation of DNA endoreduplication (GO:0032875)	3.48029098
29	keratinization (GO:0031424)	3.48006693
30	retinal rod cell development (GO:0046548)	3.46711380
31	DNA integration (GO:0015074)	3.46223288
32	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.45539875
33	negative regulation of dendrite morphogenesis (GO:0050774)	3.43971669
34	protein localization to cytoskeleton (GO:0044380)	3.33435665
35	negative regulation of B cell proliferation (GO:0030889)	3.30698632
36	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.30003311
37	regulation of translation, ncRNA-mediated (GO:0045974)	3.30003311
38	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.30003311
39	brain morphogenesis (GO:0048854)	3.27489049
40	regulation of germinal center formation (GO:0002634)	3.25096782
41	flavonoid metabolic process (GO:0009812)	3.24586881
42	cytoplasmic mRNA processing body assembly (GO:0033962)	3.21390723
43	microtubule anchoring (GO:0034453)	3.15191735
44	photoreceptor cell maintenance (GO:0045494)	3.14937395
45	single strand break repair (GO:0000012)	3.13864373
46	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.13098976
47	regulation of hippo signaling (GO:0035330)	3.12176072
48	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.10699183
49	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04008589
50	regulation of protein autophosphorylation (GO:0031952)	3.03643631
51	negative regulation of astrocyte differentiation (GO:0048712)	3.02853428
52	pericardium development (GO:0060039)	3.00902102
53	positive regulation of developmental pigmentation (GO:0048087)	2.98022655
54	Sertoli cell development (GO:0060009)	2.96977964
55	response to pheromone (GO:0019236)	2.96493988
56	positive regulation by host of viral transcription (GO:0043923)	2.94590509
57	histone mRNA catabolic process (GO:0071044)	2.92195945
58	protein prenylation (GO:0018342)	2.91824054
59	prenylation (GO:0097354)	2.91824054
60	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.91297508
61	appendage development (GO:0048736)	2.88944816
62	limb development (GO:0060173)	2.88944816
63	protein localization to Golgi apparatus (GO:0034067)	2.85354391
64	protein K48-linked deubiquitination (GO:0071108)	2.83580478
65	negative regulation of neurological system process (GO:0031645)	2.80627531
66	embryonic epithelial tube formation (GO:0001838)	2.79503974
67	tryptophan catabolic process (GO:0006569)	2.79041522
68	indole-containing compound catabolic process (GO:0042436)	2.79041522
69	indolalkylamine catabolic process (GO:0046218)	2.79041522
70	regulation of oligodendrocyte differentiation (GO:0048713)	2.73980676
71	cellular biogenic amine catabolic process (GO:0042402)	2.70398466
72	amine catabolic process (GO:0009310)	2.70398466
73	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.69724319
74	snRNA transcription (GO:0009301)	2.68528351
75	monoubiquitinated protein deubiquitination (GO:0035520)	2.66439698
76	pyrimidine dimer repair (GO:0006290)	2.64058896
77	sympathetic nervous system development (GO:0048485)	2.63462287
78	epithelial tube formation (GO:0072175)	2.62672386
79	regulation of pigment cell differentiation (GO:0050932)	2.61590380
80	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.60940485
81	olfactory bulb development (GO:0021772)	2.59873506
82	metanephric mesenchyme development (GO:0072075)	2.58936933
83	cell differentiation involved in metanephros development (GO:0072202)	2.57456707
84	cilium or flagellum-dependent cell motility (GO:0001539)	2.56460641
85	cellular response to ethanol (GO:0071361)	2.53696179
86	cranial nerve structural organization (GO:0021604)	2.53253292
87	lateral ventricle development (GO:0021670)	2.52052653
88	kynurenine metabolic process (GO:0070189)	2.51757121
89	pancreas development (GO:0031016)	2.51275027
90	magnesium ion transport (GO:0015693)	2.51239989
91	cellular response to ammonium ion (GO:0071242)	2.50328905
92	regulation of Rac protein signal transduction (GO:0035020)	2.50018392
93	cAMP catabolic process (GO:0006198)	2.49162146
94	regulation of acrosome reaction (GO:0060046)	2.48755581
95	regulation of dendritic spine morphogenesis (GO:0061001)	2.48085000
96	negative regulation of dendrite development (GO:2000171)	2.45138558
97	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.43821370
98	intestinal epithelial cell development (GO:0060576)	2.42681450
99	transepithelial transport (GO:0070633)	2.40855475
100	trophoblast giant cell differentiation (GO:0060707)	2.39996445

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.36600476
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.95179942
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.65984504
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55019350
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.51758581
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.49760254
7	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.43898542
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42726567
9	FUS_26573619_Chip-Seq_HEK293_Human	2.40198628
10	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.39725916
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.21937633
12	AR_21572438_ChIP-Seq_LNCaP_Human	2.20973414
13	EWS_26573619_Chip-Seq_HEK293_Human	2.16259731
14	P300_19829295_ChIP-Seq_ESCs_Human	2.07846392
15	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.96923606
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.92803828
17	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.90630142
18	VDR_22108803_ChIP-Seq_LS180_Human	1.89691205
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.88138546
20	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.84790964
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84337141
22	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.83305107
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79958865
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75124044
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.72609704
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.67614164
27	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.64869905
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.61143952
29	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.60975580
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.60850280
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59746525
32	TP53_16413492_ChIP-PET_HCT116_Human	1.59676960
33	STAT3_23295773_ChIP-Seq_U87_Human	1.58916388
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57915902
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57915902
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.56522026
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55925999
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.55925999
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55202307
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.54589571
41	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.53199680
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.50559124
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50307990
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48435921
45	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.47835716
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47087239
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46354569
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.45863947
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43927746
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41801269
51	CJUN_26792858_Chip-Seq_BT549_Human	1.41051781
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40899966
53	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.40651433
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40618395
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.40604862
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38057904
57	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.37412244
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.36836173
59	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.35536501
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34363140
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.33227347
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30296751
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.29139621
64	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.27466004
65	P53_22387025_ChIP-Seq_ESCs_Mouse	1.27339299
66	TCF4_23295773_ChIP-Seq_U87_Human	1.26916296
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.24617090
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24084480
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.23050986
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22568444
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20215328
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19999212
73	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.19677375
74	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19188978
75	TP53_18474530_ChIP-ChIP_U2OS_Human	1.18518570
76	TBL1_22424771_ChIP-Seq_293T_Human	1.18307887
77	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.18225149
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18163580
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.17667850
80	AR_25329375_ChIP-Seq_VCAP_Human	1.17223527
81	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.16620907
82	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.15736133
83	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.15570009
84	RXR_22108803_ChIP-Seq_LS180_Human	1.14613442
85	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.14091162
86	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.14091162
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12291406
88	NFYB_21822215_ChIP-Seq_K562_Human	1.11102311
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10494659
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10114402
91	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09796748
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08334352
93	NFYA_21822215_ChIP-Seq_K562_Human	1.08328449
94	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08254305
95	P300_18555785_Chip-Seq_ESCs_Mouse	1.06269479
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05691975
97	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.04216964
98	JUN_21703547_ChIP-Seq_K562_Human	1.03518269
99	VDR_24787735_ChIP-Seq_THP-1_Human	1.02786083
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01704449

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	6.24492994
2	MP0000569_abnormal_digit_pigmentation	5.35926567
3	MP0003195_calcinosis	3.71035644
4	MP0005645_abnormal_hypothalamus_physiol	3.45232135
5	MP0003950_abnormal_plasma_membrane	3.37117519
6	MP0010386_abnormal_urinary_bladder	2.28040578
7	MP0006276_abnormal_autonomic_nervous	2.27259505
8	MP0001501_abnormal_sleep_pattern	2.17878618
9	MP0010352_gastrointestinal_tract_polyps	2.12876442
10	MP0004270_analgesia	2.12298824
11	MP0004043_abnormal_pH_regulation	2.11100237
12	MP0005670_abnormal_white_adipose	1.99288390
13	MP0003890_abnormal_embryonic-extraembry	1.94263718
14	MP0001984_abnormal_olfaction	1.85197004
15	MP0002009_preneoplasia	1.82245272
16	MP0000372_irregular_coat_pigmentation	1.76282380
17	MP0001529_abnormal_vocalization	1.76236014
18	MP0003937_abnormal_limbs/digits/tail_de	1.69815068
19	MP0003183_abnormal_peptide_metabolism	1.67801299
20	MP0000383_abnormal_hair_follicle	1.65677029
21	MP0005551_abnormal_eye_electrophysiolog	1.62566337
22	MP0001879_abnormal_lymphatic_vessel	1.61284487
23	MP0002751_abnormal_autonomic_nervous	1.59356936
24	MP0002796_impaired_skin_barrier	1.56373676
25	MP0005253_abnormal_eye_physiology	1.51045501
26	MP0002168_other_aberrant_phenotype	1.39844394
27	MP0008058_abnormal_DNA_repair	1.39769156
28	MP0001485_abnormal_pinna_reflex	1.36597482
29	MP0008007_abnormal_cellular_replicative	1.36315452
30	MP0005503_abnormal_tendon_morphology	1.30229389
31	MP0010678_abnormal_skin_adnexa	1.30199339
32	MP0002928_abnormal_bile_duct	1.29379678
33	MP0005084_abnormal_gallbladder_morpholo	1.25292375
34	MP0002909_abnormal_adrenal_gland	1.22712532
35	MP0003045_fibrosis	1.21655383
36	MP0005187_abnormal_penis_morphology	1.19068731
37	MP0009250_abnormal_appendicular_skeleto	1.18354788
38	MP0000534_abnormal_ureter_morphology	1.17133858
39	MP0001324_abnormal_eye_pigmentation	1.15526612
40	MP0005379_endocrine/exocrine_gland_phen	1.13883571
41	MP0000647_abnormal_sebaceous_gland	1.12492395
42	MP0001299_abnormal_eye_distance/	1.11499242
43	MP0002735_abnormal_chemical_nociception	1.10855235
44	MP0000778_abnormal_nervous_system	1.10581256
45	MP0003786_premature_aging	1.09270650
46	MP0002163_abnormal_gland_morphology	1.07315394
47	MP0009046_muscle_twitch	1.05998023
48	MP0000427_abnormal_hair_cycle	1.05850025
49	MP0000538_abnormal_urinary_bladder	1.05208695
50	MP0005623_abnormal_meninges_morphology	1.03008417
51	MP0004134_abnormal_chest_morphology	1.01632406
52	MP0002090_abnormal_vision	1.01057256
53	MP0005197_abnormal_uvea_morphology	0.99306776
54	MP0005310_abnormal_salivary_gland	0.98453490
55	MP0002638_abnormal_pupillary_reflex	0.98425324
56	MP0002184_abnormal_innervation	0.97721494
57	MP0008877_abnormal_DNA_methylation	0.96391465
58	MP0001346_abnormal_lacrimal_gland	0.95923479
59	MP0005391_vision/eye_phenotype	0.95866377
60	MP0001286_abnormal_eye_development	0.95160187
61	MP0002160_abnormal_reproductive_system	0.94130053
62	MP0002108_abnormal_muscle_morphology	0.93965061
63	MP0003943_abnormal_hepatobiliary_system	0.93089186
64	MP0000371_diluted_coat_color	0.92768077
65	MP0005195_abnormal_posterior_eye	0.92252766
66	MP0005395_other_phenotype	0.88531923
67	MP0002102_abnormal_ear_morphology	0.87067190
68	MP0004510_myositis	0.86358320
69	MP0003646_muscle_fatigue	0.85298043
70	MP0000631_abnormal_neuroendocrine_gland	0.83764455
71	MP0004484_altered_response_of	0.83487549
72	MP0000639_abnormal_adrenal_gland	0.81789687
73	MP0001191_abnormal_skin_condition	0.81680925
74	MP0009697_abnormal_copulation	0.80232496
75	MP0002233_abnormal_nose_morphology	0.80008782
76	MP0003942_abnormal_urinary_system	0.79553995
77	MP0008995_early_reproductive_senescence	0.79297187
78	MP0005083_abnormal_biliary_tract	0.79146756
79	MP0004885_abnormal_endolymph	0.78435720
80	MP0005174_abnormal_tail_pigmentation	0.77720191
81	MP0003221_abnormal_cardiomyocyte_apopto	0.76637709
82	MP0009780_abnormal_chondrocyte_physiolo	0.75930706
83	MP0004085_abnormal_heartbeat	0.75578404
84	MP0002332_abnormal_exercise_endurance	0.74094480
85	MP0005646_abnormal_pituitary_gland	0.71300360
86	MP0005367_renal/urinary_system_phenotyp	0.69495389
87	MP0000516_abnormal_urinary_system	0.69495389
88	MP0002752_abnormal_somatic_nervous	0.68313341
89	MP0002557_abnormal_social/conspecific_i	0.67926324
90	MP0005085_abnormal_gallbladder_physiolo	0.66973087
91	MP0004924_abnormal_behavior	0.66651208
92	MP0005386_behavior/neurological_phenoty	0.66651208
93	MP0009745_abnormal_behavioral_response	0.64932528
94	MP0003252_abnormal_bile_duct	0.64902148
95	MP0003787_abnormal_imprinting	0.64628457
96	MP0003755_abnormal_palate_morphology	0.63390731
97	MP0000026_abnormal_inner_ear	0.62411260
98	MP0009115_abnormal_fat_cell	0.61854601
99	MP0002166_altered_tumor_susceptibility	0.61499077
100	MP0001119_abnormal_female_reproductive	0.58103566

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of macular pigmentation (HP:0008002)	4.19212258
2	Pheochromocytoma (HP:0002666)	3.93801161
3	Volvulus (HP:0002580)	3.91040610
4	Neuroendocrine neoplasm (HP:0100634)	3.88756251
5	Atonic seizures (HP:0010819)	3.85313984
6	Tubulointerstitial nephritis (HP:0001970)	3.41917876
7	Long clavicles (HP:0000890)	3.27785272
8	Chronic hepatic failure (HP:0100626)	3.18795749
9	Progressive cerebellar ataxia (HP:0002073)	3.08177078
10	Genetic anticipation (HP:0003743)	3.01867015
11	Autoamputation (HP:0001218)	2.91559417
12	Alopecia of scalp (HP:0002293)	2.89999295
13	Pancreatic cysts (HP:0001737)	2.77208440
14	Vaginal atresia (HP:0000148)	2.75850091
15	True hermaphroditism (HP:0010459)	2.74975225
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.73855793
17	Absent/shortened dynein arms (HP:0200106)	2.73855793
18	Recurrent pneumonia (HP:0006532)	2.73581054
19	Nephronophthisis (HP:0000090)	2.71240297
20	Medial flaring of the eyebrow (HP:0010747)	2.68565276
21	Genital tract atresia (HP:0001827)	2.66886300
22	Vascular calcification (HP:0004934)	2.66611409
23	Poikiloderma (HP:0001029)	2.63682371
24	Chorioretinal atrophy (HP:0000533)	2.60988754
25	Anhidrosis (HP:0000970)	2.59775995
26	Macular degeneration (HP:0000608)	2.56751467
27	Gaze-evoked nystagmus (HP:0000640)	2.55425789
28	Decreased central vision (HP:0007663)	2.46437597
29	Diastasis recti (HP:0001540)	2.46137173
30	11 pairs of ribs (HP:0000878)	2.44373495
31	Gait imbalance (HP:0002141)	2.40438696
32	Blepharitis (HP:0000498)	2.39269819
33	Congenital primary aphakia (HP:0007707)	2.37750010
34	Papillary thyroid carcinoma (HP:0002895)	2.36478617
35	Cardiovascular calcification (HP:0011915)	2.36474519
36	Short chin (HP:0000331)	2.34130081
37	Poor coordination (HP:0002370)	2.33690510
38	Thyroid carcinoma (HP:0002890)	2.30246211
39	Cellular immunodeficiency (HP:0005374)	2.27507988
40	Wide intermamillary distance (HP:0006610)	2.20292834
41	Nephrogenic diabetes insipidus (HP:0009806)	2.17574695
42	Urethral obstruction (HP:0000796)	2.16871177
43	Abnormality of the renal medulla (HP:0100957)	2.16688910
44	Follicular hyperkeratosis (HP:0007502)	2.16353370
45	Hypophosphatemic rickets (HP:0004912)	2.16137053
46	Abnormal pancreas size (HP:0012094)	2.13829446
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.13634903
48	Fair hair (HP:0002286)	2.08320914
49	Ectropion (HP:0000656)	2.08094384
50	Neoplasm of the peripheral nervous system (HP:0100007)	2.05380160
51	Abnormal hair whorl (HP:0010721)	2.00362820
52	Hypoplastic iliac wings (HP:0002866)	1.99819874
53	Abnormality of the labia majora (HP:0012881)	1.95437668
54	Menstrual irregularities (HP:0000858)	1.95053168
55	Hip dysplasia (HP:0001385)	1.94368280
56	Urinary bladder sphincter dysfunction (HP:0002839)	1.92036777
57	Truncal obesity (HP:0001956)	1.91711046
58	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.91347076
59	Astrocytoma (HP:0009592)	1.91098105
60	Abnormality of the astrocytes (HP:0100707)	1.91098105
61	Abnormality of the axillary hair (HP:0100134)	1.89263824
62	Abnormality of secondary sexual hair (HP:0009888)	1.89263824
63	Recurrent sinusitis (HP:0011108)	1.88949789
64	Fibular aplasia (HP:0002990)	1.86876389
65	Missing ribs (HP:0000921)	1.86640486
66	Attenuation of retinal blood vessels (HP:0007843)	1.85515237
67	Fibular hypoplasia (HP:0003038)	1.81495060
68	Abnormality of nail color (HP:0100643)	1.81431527
69	Submucous cleft hard palate (HP:0000176)	1.79755173
70	Midline defect of the nose (HP:0004122)	1.79200569
71	Aplasia/Hypoplasia of the lens (HP:0008063)	1.79065164
72	Tubular atrophy (HP:0000092)	1.78594811
73	Bicornuate uterus (HP:0000813)	1.78413315
74	Febrile seizures (HP:0002373)	1.77311659
75	Sensory axonal neuropathy (HP:0003390)	1.76836928
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.76309957
77	Lip pit (HP:0100267)	1.72395491
78	Thyroid-stimulating hormone excess (HP:0002925)	1.71710119
79	Curly hair (HP:0002212)	1.71644214
80	Abnormality of the nasal septum (HP:0000419)	1.70247431
81	Dyschromatopsia (HP:0007641)	1.68392763
82	Hypoplastic labia majora (HP:0000059)	1.66687837
83	Molar tooth sign on MRI (HP:0002419)	1.66364493
84	Abnormality of midbrain morphology (HP:0002418)	1.66364493
85	Glioma (HP:0009733)	1.63243714
86	Chronic bronchitis (HP:0004469)	1.62143336
87	Thoracolumbar scoliosis (HP:0002944)	1.61109843
88	Widely spaced teeth (HP:0000687)	1.60755144
89	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.60498226
90	Abnormal ciliary motility (HP:0012262)	1.59663809
91	Hyperventilation (HP:0002883)	1.59381029
92	Growth hormone deficiency (HP:0000824)	1.59187155
93	Inability to walk (HP:0002540)	1.58868859
94	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.58596066
95	Hypoplastic scapulae (HP:0000882)	1.58596066
96	Renal hypoplasia (HP:0000089)	1.58571698
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.58284181
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.58284181
99	Thyroiditis (HP:0100646)	1.57719538
100	Medulloblastoma (HP:0002885)	1.57132068

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.12627448
2	MAP3K4	3.32444322
3	MST4	3.12116267
4	ACVR1B	2.93326836
5	BCR	2.36546561
6	CSNK1A1L	2.35021479
7	MKNK2	2.32163398
8	BRSK2	2.31326504
9	MAP2K7	2.24058635
10	BMPR1B	2.20230166
11	EIF2AK3	2.15100168
12	MAP3K6	2.09126927
13	TNIK	2.02348045
14	ADRBK2	1.93064421
15	NEK6	1.89625774
16	AKT3	1.89513976
17	BLK	1.87827648
18	STK39	1.77410147
19	WNK3	1.72801585
20	ERBB3	1.57335106
21	CASK	1.57218196
22	WNK1	1.54828621
23	STK3	1.52626524
24	GRK1	1.50376284
25	CDK12	1.45177208
26	CAMK1D	1.40087502
27	STK24	1.38524348
28	WEE1	1.37038752
29	BRD4	1.32863707
30	CAMK1G	1.32206582
31	CSNK1G2	1.30775173
32	MAPK13	1.29656289
33	MAP2K4	1.27638450
34	CSNK1G1	1.23697174
35	CLK1	1.21906261
36	CSNK1G3	1.20024840
37	TIE1	1.17444737
38	GRK7	1.14097972
39	MARK1	1.11287599
40	DYRK3	1.10204788
41	TGFBR2	1.07638488
42	MATK	1.07196781
43	TEC	1.02822773
44	WNK4	1.02643750
45	TRIM28	1.00750243
46	VRK1	1.00642232
47	MKNK1	1.00386969
48	ADRBK1	0.99967576
49	STK38L	0.98508649
50	TAF1	0.98013656
51	SRPK1	0.94177737
52	CAMKK2	0.92988980
53	BUB1	0.92517245
54	PRKCE	0.91625502
55	EIF2AK2	0.88337528
56	MAP3K2	0.87848619
57	TXK	0.87448886
58	PNCK	0.82853348
59	ICK	0.78973208
60	BMPR2	0.78949977
61	STK38	0.78525921
62	TGFBR1	0.74093511
63	SGK2	0.72133510
64	STK10	0.70172773
65	OXSR1	0.67798005
66	NLK	0.67061663
67	NUAK1	0.63731308
68	PRKCG	0.61714048
69	ATM	0.61023107
70	EPHA2	0.58424216
71	CAMK4	0.56727084
72	JAK1	0.51952724
73	PRKAA2	0.51303254
74	FGFR1	0.50416681
75	ERBB4	0.49103595
76	PLK2	0.47524240
77	YES1	0.45770256
78	NEK9	0.44385357
79	PIK3CA	0.42768782
80	PAK3	0.42356071
81	EGFR	0.39602677
82	DYRK1A	0.39458916
83	FLT3	0.38597084
84	MAP2K6	0.38229234
85	ERBB2	0.35588290
86	INSRR	0.33250217
87	PDGFRB	0.33013042
88	ABL1	0.32586700
89	MAP3K5	0.31922768
90	SGK494	0.31744406
91	SGK223	0.31744406
92	LATS1	0.31442872
93	DDR2	0.31126330
94	PRKAA1	0.30663593
95	PLK4	0.30533715
96	OBSCN	0.30285483
97	CHEK2	0.28980697
98	IGF1R	0.28166267
99	CSNK1D	0.26685666
100	CAMK1	0.26664431

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.88141423
2	Taste transduction_Homo sapiens_hsa04742	2.95480352
3	Basal transcription factors_Homo sapiens_hsa03022	2.46645011
4	Phototransduction_Homo sapiens_hsa04744	2.29714402
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.21193012
6	Circadian rhythm_Homo sapiens_hsa04710	2.03432899
7	Morphine addiction_Homo sapiens_hsa05032	2.01090089
8	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.94728208
9	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.90959085
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69174239
11	Protein export_Homo sapiens_hsa03060	1.66049834
12	GABAergic synapse_Homo sapiens_hsa04727	1.64012795
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.55995746
14	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.45860615
15	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.42623038
16	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.36414270
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36302572
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.34600911
19	Adherens junction_Homo sapiens_hsa04520	1.29471058
20	Type II diabetes mellitus_Homo sapiens_hsa04930	1.27431457
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.26391115
22	Olfactory transduction_Homo sapiens_hsa04740	1.24222234
23	mRNA surveillance pathway_Homo sapiens_hsa03015	1.21115370
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.20293606
25	RNA degradation_Homo sapiens_hsa03018	1.19859736
26	Sulfur metabolism_Homo sapiens_hsa00920	1.17446907
27	p53 signaling pathway_Homo sapiens_hsa04115	1.14730149
28	RNA transport_Homo sapiens_hsa03013	1.13785384
29	Regulation of autophagy_Homo sapiens_hsa04140	1.08619040
30	Serotonergic synapse_Homo sapiens_hsa04726	1.08034627
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02774210
32	Alcoholism_Homo sapiens_hsa05034	0.99721630
33	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.98125605
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98045745
35	Selenocompound metabolism_Homo sapiens_hsa00450	0.97951989
36	FoxO signaling pathway_Homo sapiens_hsa04068	0.97418976
37	TNF signaling pathway_Homo sapiens_hsa04668	0.96552486
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.93272453
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92882242
40	Tight junction_Homo sapiens_hsa04530	0.92633126
41	Caffeine metabolism_Homo sapiens_hsa00232	0.91230988
42	Homologous recombination_Homo sapiens_hsa03440	0.89392934
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88107782
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.88096497
45	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.85918550
46	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.85569821
47	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.84760838
48	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.82705635
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.80469416
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.79466802
51	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.79115594
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78938956
53	Sphingolipid metabolism_Homo sapiens_hsa00600	0.78556967
54	Hippo signaling pathway_Homo sapiens_hsa04390	0.77424969
55	Colorectal cancer_Homo sapiens_hsa05210	0.76256624
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.75482221
57	Cocaine addiction_Homo sapiens_hsa05030	0.75178928
58	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.74544130
59	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.73530395
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.73438564
61	Wnt signaling pathway_Homo sapiens_hsa04310	0.71494897
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70549244
63	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.70514043
64	Choline metabolism in cancer_Homo sapiens_hsa05231	0.70027688
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68099983
66	Oocyte meiosis_Homo sapiens_hsa04114	0.64757417
67	ABC transporters_Homo sapiens_hsa02010	0.63411069
68	MicroRNAs in cancer_Homo sapiens_hsa05206	0.62819499
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.62653028
70	Retinol metabolism_Homo sapiens_hsa00830	0.61948221
71	Renal cell carcinoma_Homo sapiens_hsa05211	0.61404194
72	Influenza A_Homo sapiens_hsa05164	0.60456984
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.60163403
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59675698
75	Gastric acid secretion_Homo sapiens_hsa04971	0.58579878
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58404387
77	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.58369171
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.57064497
79	Cell cycle_Homo sapiens_hsa04110	0.56905410
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.55830025
81	Amphetamine addiction_Homo sapiens_hsa05031	0.55621961
82	Axon guidance_Homo sapiens_hsa04360	0.54442022
83	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.51624432
84	Rap1 signaling pathway_Homo sapiens_hsa04015	0.50911220
85	Salivary secretion_Homo sapiens_hsa04970	0.50835864
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.50717708
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50581806
88	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.50487910
89	Hepatitis C_Homo sapiens_hsa05160	0.49987085
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49907683
91	Measles_Homo sapiens_hsa05162	0.49851415
92	Rheumatoid arthritis_Homo sapiens_hsa05323	0.48416481
93	Cholinergic synapse_Homo sapiens_hsa04725	0.48291646
94	RNA polymerase_Homo sapiens_hsa03020	0.47548192
95	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.46526823
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44813849
97	Prostate cancer_Homo sapiens_hsa05215	0.40808476
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.40615171
99	Prolactin signaling pathway_Homo sapiens_hsa04917	0.39802065
100	Viral carcinogenesis_Homo sapiens_hsa05203	0.39402799

MAPK6PS3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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