ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.71379876
2	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.71379876
3	NADH dehydrogenase complex assembly (GO:0010257)	5.71379876
4	opioid receptor signaling pathway (GO:0038003)	4.84348402
5	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.55073695
6	behavioral response to nicotine (GO:0035095)	4.39261460
7	protein complex biogenesis (GO:0070271)	4.22124461
8	sequestering of actin monomers (GO:0042989)	3.78687373
9	cell migration in hindbrain (GO:0021535)	3.75886696
10	DNA damage response, detection of DNA damage (GO:0042769)	3.70716791
11	forebrain neuron differentiation (GO:0021879)	3.69567850
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60624813
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.55551124
14	somite rostral/caudal axis specification (GO:0032525)	3.46925073
15	resolution of meiotic recombination intermediates (GO:0000712)	3.46611135
16	regulation of mitotic spindle checkpoint (GO:1903504)	3.39823394
17	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.39823394
18	pyrimidine nucleobase catabolic process (GO:0006208)	3.31592014
19	mitochondrial calcium ion transport (GO:0006851)	3.29242354
20	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.24145982
21	DNA double-strand break processing (GO:0000729)	3.23559790
22	neurotransmitter-gated ion channel clustering (GO:0072578)	3.21340196
23	positive regulation of cell cycle checkpoint (GO:1901978)	3.19445421
24	positive regulation by host of viral transcription (GO:0043923)	3.15529138
25	lateral ventricle development (GO:0021670)	3.12620938
26	retina layer formation (GO:0010842)	3.12004779
27	seminiferous tubule development (GO:0072520)	3.11215548
28	viral transcription (GO:0019083)	3.09166743
29	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.07233348
30	ATP synthesis coupled proton transport (GO:0015986)	3.07233348
31	protein localization to synapse (GO:0035418)	3.06117822
32	organ growth (GO:0035265)	3.01362526
33	translational termination (GO:0006415)	2.96967882
34	somite development (GO:0061053)	2.95588104
35	left/right axis specification (GO:0070986)	2.95308008
36	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.93536768
37	regulation of translation, ncRNA-mediated (GO:0045974)	2.93536768
38	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.93536768
39	segment specification (GO:0007379)	2.93472026
40	cellular anion homeostasis (GO:0030002)	2.87894062
41	attachment of spindle microtubules to kinetochore (GO:0008608)	2.87817611
42	hindbrain development (GO:0030902)	2.87256426
43	kynurenine metabolic process (GO:0070189)	2.84869861
44	dendritic spine morphogenesis (GO:0060997)	2.84804729
45	serotonin receptor signaling pathway (GO:0007210)	2.82584333
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.80709398
47	regulation of respiratory system process (GO:0044065)	2.76596968
48	midbrain development (GO:0030901)	2.76035462
49	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.75810651
50	chaperone-mediated protein transport (GO:0072321)	2.74102859
51	short-term memory (GO:0007614)	2.71667811
52	sympathetic nervous system development (GO:0048485)	2.71353545
53	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.71190302
54	nonmotile primary cilium assembly (GO:0035058)	2.68924605
55	limb bud formation (GO:0060174)	2.68484583
56	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.67914682
57	replication fork processing (GO:0031297)	2.67793661
58	positive regulation of synapse assembly (GO:0051965)	2.66611483
59	primitive streak formation (GO:0090009)	2.66461883
60	head development (GO:0060322)	2.66195449
61	cellular ketone body metabolic process (GO:0046950)	2.65717415
62	kidney mesenchyme development (GO:0072074)	2.65642087
63	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.65166973
64	nucleobase catabolic process (GO:0046113)	2.64354398
65	neuromuscular process controlling posture (GO:0050884)	2.64117188
66	chromatin remodeling at centromere (GO:0031055)	2.63378968
67	behavioral response to ethanol (GO:0048149)	2.63333658
68	protein localization to chromosome (GO:0034502)	2.62598375
69	dopaminergic neuron differentiation (GO:0071542)	2.61239940
70	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.58495654
71	endoderm formation (GO:0001706)	2.56895622
72	regulation of appetite (GO:0032098)	2.56836149
73	microtubule anchoring (GO:0034453)	2.56276434
74	regulation of meiosis I (GO:0060631)	2.56085637
75	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.55952750
76	neural tube formation (GO:0001841)	2.55744078
77	otic vesicle formation (GO:0030916)	2.55690320
78	spinal cord motor neuron differentiation (GO:0021522)	2.54622066
79	monoubiquitinated protein deubiquitination (GO:0035520)	2.53362097
80	epithelial cilium movement (GO:0003351)	2.53110423
81	striatum development (GO:0021756)	2.52406187
82	neuron remodeling (GO:0016322)	2.51874810
83	regulation of timing of cell differentiation (GO:0048505)	2.51211873
84	establishment of mitochondrion localization (GO:0051654)	2.50053352
85	organelle disassembly (GO:1903008)	2.49718386
86	DNA integration (GO:0015074)	2.49530485
87	microtubule depolymerization (GO:0007019)	2.48239178
88	phosphate ion homeostasis (GO:0055062)	2.46229674
89	trivalent inorganic anion homeostasis (GO:0072506)	2.46229674
90	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.45935143
91	centriole replication (GO:0007099)	2.45668825
92	presynaptic membrane assembly (GO:0097105)	2.45313262
93	vitamin transmembrane transport (GO:0035461)	2.45011501
94	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.44095469
95	cotranslational protein targeting to membrane (GO:0006613)	2.43940712
96	cell differentiation in spinal cord (GO:0021515)	2.43765107
97	regulation of cellular senescence (GO:2000772)	2.43710679
98	indole-containing compound catabolic process (GO:0042436)	2.42725048
99	indolalkylamine catabolic process (GO:0046218)	2.42725048
100	tryptophan catabolic process (GO:0006569)	2.42725048

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.54978920
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.12864644
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01862360
4	VDR_22108803_ChIP-Seq_LS180_Human	2.81469649
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67643883
6	EWS_26573619_Chip-Seq_HEK293_Human	2.64577577
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58337963
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.44404608
9	FUS_26573619_Chip-Seq_HEK293_Human	2.43610309
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.39330651
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.38829250
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.34544120
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14158965
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.10606504
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09518396
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.08831695
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06298063
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.06298063
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05807751
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.98272025
21	P300_19829295_ChIP-Seq_ESCs_Human	1.96059654
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92395724
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91453750
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83815032
25	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.81271500
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.81172207
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.78512579
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.74375379
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.70352358
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64644345
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.64426343
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.60223767
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.59837392
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59463206
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57501492
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.55966082
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.54605684
38	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.48208985
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.44854832
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44820292
41	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44819237
42	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.44697390
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42452499
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42293141
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42000233
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39558521
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39408211
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37658634
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.36472750
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35361776
51	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.33647577
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31817300
53	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31739529
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31734780
55	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.31541029
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.30091134
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.29795902
58	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.28727046
59	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.28148817
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26981347
61	AR_25329375_ChIP-Seq_VCAP_Human	1.23270403
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22137765
63	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.21058963
64	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20928464
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19955165
66	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17801896
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17332956
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.17300656
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16232503
70	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.15966166
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.15430194
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14615451
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.13279199
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11563179
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10837996
76	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.10346922
77	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.09779118
78	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.09779118
79	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09111656
80	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.08296636
81	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08146702
82	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06865031
83	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.06642151
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06005584
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05641981
86	JUN_21703547_ChIP-Seq_K562_Human	1.05470116
87	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05004781
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03549365
89	TCF4_22108803_ChIP-Seq_LS180_Human	1.03318924
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02894537
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02869873
92	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.02122835
93	P300_18555785_Chip-Seq_ESCs_Mouse	1.02071061
94	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01747230
95	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01747230
96	TP53_22573176_ChIP-Seq_HFKS_Human	1.00947257
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.00243642
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00177880
99	AR_21909140_ChIP-Seq_LNCAP_Human	0.96851525
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.96765424

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	4.89380946
2	MP0000569_abnormal_digit_pigmentation	4.80398950
3	MP0002822_catalepsy	3.24251181
4	MP0001293_anophthalmia	2.40852362
5	MP0008961_abnormal_basal_metabolism	2.37646054
6	MP0003880_abnormal_central_pattern	2.33972490
7	MP0003890_abnormal_embryonic-extraembry	2.22254514
8	MP0001529_abnormal_vocalization	2.10643064
9	MP0006072_abnormal_retinal_apoptosis	2.08299312
10	MP0004133_heterotaxia	2.04732809
11	MP0005423_abnormal_somatic_nervous	2.03487442
12	MP0003119_abnormal_digestive_system	2.02439561
13	MP0002938_white_spotting	2.01952962
14	MP0001346_abnormal_lacrimal_gland	2.00764203
15	MP0002735_abnormal_chemical_nociception	1.90850464
16	MP0000372_irregular_coat_pigmentation	1.89919617
17	MP0003787_abnormal_imprinting	1.86604669
18	MP0006292_abnormal_olfactory_placode	1.80955445
19	MP0002009_preneoplasia	1.79342733
20	MP0002234_abnormal_pharynx_morphology	1.74730127
21	MP0000631_abnormal_neuroendocrine_gland	1.71083421
22	MP0000778_abnormal_nervous_system	1.70666310
23	MP0002102_abnormal_ear_morphology	1.70314174
24	MP0004142_abnormal_muscle_tone	1.69380825
25	MP0008877_abnormal_DNA_methylation	1.68851970
26	MP0003567_abnormal_fetal_cardiomyocyte	1.62364448
27	MP0003937_abnormal_limbs/digits/tail_de	1.43372477
28	MP0002572_abnormal_emotion/affect_behav	1.37123585
29	MP0003315_abnormal_perineum_morphology	1.35770968
30	MP0005645_abnormal_hypothalamus_physiol	1.30965088
31	MP0005551_abnormal_eye_electrophysiolog	1.30961765
32	MP0003283_abnormal_digestive_organ	1.30956639
33	MP0005253_abnormal_eye_physiology	1.29412122
34	MP0003635_abnormal_synaptic_transmissio	1.29205136
35	MP0006276_abnormal_autonomic_nervous	1.27498281
36	MP0001486_abnormal_startle_reflex	1.27481551
37	MP0000462_abnormal_digestive_system	1.27361309
38	MP0009745_abnormal_behavioral_response	1.27095265
39	MP0001299_abnormal_eye_distance/	1.25571290
40	MP0005187_abnormal_penis_morphology	1.24722572
41	MP0005386_behavior/neurological_phenoty	1.24530255
42	MP0004924_abnormal_behavior	1.24530255
43	MP0000537_abnormal_urethra_morphology	1.19465410
44	MP0002736_abnormal_nociception_after	1.17027160
45	MP0004742_abnormal_vestibular_system	1.15405950
46	MP0002272_abnormal_nervous_system	1.15133191
47	MP0003941_abnormal_skin_development	1.14733306
48	MP0002067_abnormal_sensory_capabilities	1.14022433
49	MP0002653_abnormal_ependyma_morphology	1.13797826
50	MP0004043_abnormal_pH_regulation	1.10793535
51	MP0002752_abnormal_somatic_nervous	1.09561643
52	MP0001905_abnormal_dopamine_level	1.07633709
53	MP0000647_abnormal_sebaceous_gland	1.07599527
54	MP0003121_genomic_imprinting	1.07522005
55	MP0002064_seizures	1.06822197
56	MP0005195_abnormal_posterior_eye	1.06543391
57	MP0002733_abnormal_thermal_nociception	1.06476566
58	MP0008995_early_reproductive_senescence	1.05955645
59	MP0003861_abnormal_nervous_system	1.05197639
60	MP0002063_abnormal_learning/memory/cond	1.03242296
61	MP0000579_abnormal_nail_morphology	1.03152341
62	MP0010030_abnormal_orbit_morphology	1.03058122
63	MP0003195_calcinosis	1.01484720
64	MP0002233_abnormal_nose_morphology	1.00918819
65	MP0005448_abnormal_energy_balance	0.98798001
66	MP0005391_vision/eye_phenotype	0.98740091
67	MP0002734_abnormal_mechanical_nocicepti	0.97948553
68	MP0001970_abnormal_pain_threshold	0.97936471
69	MP0008789_abnormal_olfactory_epithelium	0.97819389
70	MP0002557_abnormal_social/conspecific_i	0.97578999
71	MP0009046_muscle_twitch	0.97096218
72	MP0001286_abnormal_eye_development	0.96488230
73	MP0002069_abnormal_eating/drinking_beha	0.96026961
74	MP0000026_abnormal_inner_ear	0.94857023
75	MP0009379_abnormal_foot_pigmentation	0.94846078
76	MP0008058_abnormal_DNA_repair	0.94237307
77	MP0001968_abnormal_touch/_nociception	0.94090578
78	MP0002882_abnormal_neuron_morphology	0.93229291
79	MP0000383_abnormal_hair_follicle	0.92909807
80	MP0001664_abnormal_digestion	0.92460191
81	MP0002638_abnormal_pupillary_reflex	0.91336537
82	MP0010386_abnormal_urinary_bladder	0.89831934
83	MP0003878_abnormal_ear_physiology	0.88665887
84	MP0005377_hearing/vestibular/ear_phenot	0.88665887
85	MP0003385_abnormal_body_wall	0.88429905
86	MP0000955_abnormal_spinal_cord	0.88065299
87	MP0002152_abnormal_brain_morphology	0.87289554
88	MP0005167_abnormal_blood-brain_barrier	0.86693817
89	MP0003693_abnormal_embryo_hatching	0.86047798
90	MP0005084_abnormal_gallbladder_morpholo	0.85056871
91	MP0004885_abnormal_endolymph	0.81090608
92	MP0004215_abnormal_myocardial_fiber	0.79744366
93	MP0002092_abnormal_eye_morphology	0.79307553
94	MP0000427_abnormal_hair_cycle	0.79191942
95	MP0001440_abnormal_grooming_behavior	0.78392976
96	MP0004147_increased_porphyrin_level	0.77856551
97	MP0002751_abnormal_autonomic_nervous	0.77584043
98	MP0003698_abnormal_male_reproductive	0.77214035
99	MP0004270_analgesia	0.75455659
100	MP0002697_abnormal_eye_size	0.74461096

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.96344861
2	Supernumerary spleens (HP:0009799)	3.61889090
3	Symphalangism affecting the phalanges of the hand (HP:0009773)	3.54865934
4	Pancreatic fibrosis (HP:0100732)	3.42340559
5	True hermaphroditism (HP:0010459)	3.34171356
6	Colon cancer (HP:0003003)	3.33962485
7	Molar tooth sign on MRI (HP:0002419)	3.24140528
8	Abnormality of midbrain morphology (HP:0002418)	3.24140528
9	Thyroid-stimulating hormone excess (HP:0002925)	3.17980148
10	Congenital stationary night blindness (HP:0007642)	3.09127595
11	Medial flaring of the eyebrow (HP:0010747)	2.86729606
12	Gait imbalance (HP:0002141)	2.83701761
13	Vaginal atresia (HP:0000148)	2.74667876
14	Humeroradial synostosis (HP:0003041)	2.70556948
15	Synostosis involving the elbow (HP:0003938)	2.70556948
16	Genital tract atresia (HP:0001827)	2.66978545
17	Nephronophthisis (HP:0000090)	2.66103393
18	Cystic liver disease (HP:0006706)	2.58885753
19	Concave nail (HP:0001598)	2.53738645
20	Hyperalaninemia (HP:0003348)	2.52718115
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52718115
22	Abnormality of alanine metabolism (HP:0010916)	2.52718115
23	Congenital primary aphakia (HP:0007707)	2.50761165
24	11 pairs of ribs (HP:0000878)	2.48480221
25	Coronal craniosynostosis (HP:0004440)	2.46544714
26	Hypoplasia of the pons (HP:0012110)	2.46264499
27	Type II lissencephaly (HP:0007260)	2.43936751
28	Intestinal atresia (HP:0011100)	2.43295971
29	Abnormality of the pons (HP:0007361)	2.39328566
30	Abnormality of the lacrimal duct (HP:0011481)	2.37411071
31	Mutism (HP:0002300)	2.36571429
32	Hepatocellular necrosis (HP:0001404)	2.36220851
33	Abnormal biliary tract physiology (HP:0012439)	2.31347397
34	Bile duct proliferation (HP:0001408)	2.31347397
35	Agitation (HP:0000713)	2.26169706
36	Birth length less than 3rd percentile (HP:0003561)	2.24150246
37	Abnormality of the nasolacrimal system (HP:0000614)	2.23971710
38	Intellectual disability, moderate (HP:0002342)	2.21110543
39	Genetic anticipation (HP:0003743)	2.20796795
40	Pendular nystagmus (HP:0012043)	2.20060536
41	Nephrogenic diabetes insipidus (HP:0009806)	2.18841209
42	Anophthalmia (HP:0000528)	2.17882554
43	Methylmalonic acidemia (HP:0002912)	2.17165171
44	Oligodactyly (hands) (HP:0001180)	2.16501115
45	Patellar aplasia (HP:0006443)	2.15978833
46	Broad-based gait (HP:0002136)	2.12113927
47	Occipital encephalocele (HP:0002085)	2.11810158
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11461881
49	Partial duplication of the phalanx of hand (HP:0009999)	2.09857771
50	Anteriorly placed anus (HP:0001545)	2.08488250
51	Ulnar claw (HP:0001178)	2.06250017
52	Hyperglycinemia (HP:0002154)	2.04565573
53	Sclerocornea (HP:0000647)	2.04043225
54	Chronic hepatic failure (HP:0100626)	2.01783614
55	Abnormality of the middle phalanges of the toes (HP:0010183)	1.98788181
56	Anencephaly (HP:0002323)	1.98712339
57	Morphological abnormality of the pyramidal tract (HP:0002062)	1.98051145
58	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.96788679
59	Gastrointestinal atresia (HP:0002589)	1.96634794
60	Split foot (HP:0001839)	1.96540420
61	Nasolacrimal duct obstruction (HP:0000579)	1.96336432
62	Severe Myopia (HP:0011003)	1.96332096
63	Abnormality of the labia minora (HP:0012880)	1.95119785
64	Abnormality of the renal medulla (HP:0100957)	1.94874607
65	Poor coordination (HP:0002370)	1.92711155
66	Gonadotropin excess (HP:0000837)	1.92634486
67	Mitochondrial inheritance (HP:0001427)	1.92233434
68	Aplasia/Hypoplasia of the patella (HP:0006498)	1.91798858
69	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.91653912
70	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.91653912
71	Dialeptic seizures (HP:0011146)	1.88410458
72	Increased hepatocellular lipid droplets (HP:0006565)	1.88379845
73	Inability to walk (HP:0002540)	1.88256661
74	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.86394333
75	Esophageal atresia (HP:0002032)	1.85674280
76	Abnormal lung lobation (HP:0002101)	1.85447042
77	Pigmentary retinal degeneration (HP:0001146)	1.85421619
78	Clumsiness (HP:0002312)	1.81663341
79	Myokymia (HP:0002411)	1.80280845
80	Decreased central vision (HP:0007663)	1.80253917
81	Hepatic necrosis (HP:0002605)	1.79694898
82	Acute encephalopathy (HP:0006846)	1.79686149
83	Hyperglycinuria (HP:0003108)	1.79597512
84	Bilateral microphthalmos (HP:0007633)	1.79505399
85	Male pseudohermaphroditism (HP:0000037)	1.79087097
86	Partial duplication of thumb phalanx (HP:0009944)	1.78388988
87	Limb dystonia (HP:0002451)	1.78043983
88	Stenosis of the external auditory canal (HP:0000402)	1.77312281
89	Acute necrotizing encephalopathy (HP:0006965)	1.77203230
90	Furrowed tongue (HP:0000221)	1.75581521
91	Confusion (HP:0001289)	1.75003195
92	Chorioretinal atrophy (HP:0000533)	1.74612144
93	Increased CSF lactate (HP:0002490)	1.73374273
94	Preaxial hand polydactyly (HP:0001177)	1.70261163
95	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.69974669
96	Postaxial hand polydactyly (HP:0001162)	1.69880347
97	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.69647411
98	Pheochromocytoma (HP:0002666)	1.68800448
99	Abnormality of the parietal bone (HP:0002696)	1.68762970
100	Microretrognathia (HP:0000308)	1.67844245

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K4	3.58197279
2	CASK	3.29365405
3	TIE1	2.99725949
4	BMPR1B	2.91807612
5	WNK3	2.84254610
6	ACVR1B	2.70594029
7	VRK2	2.70423514
8	ADRBK2	2.63018600
9	WEE1	2.53364759
10	GRK1	2.39473337
11	VRK1	2.05784134
12	TYRO3	2.00076877
13	FGFR2	1.97061110
14	MAP2K7	1.85914885
15	TGFBR1	1.78517236
16	DYRK3	1.76588881
17	CAMK1D	1.72236413
18	MARK1	1.70883610
19	NTRK2	1.70502202
20	EPHB2	1.67208363
21	BCR	1.65477295
22	BLK	1.63464114
23	MAPK13	1.60037823
24	DYRK2	1.59683557
25	NEK2	1.58017730
26	UHMK1	1.40061319
27	PNCK	1.28602454
28	STK3	1.28337332
29	SRPK1	1.28161958
30	NUAK1	1.26814025
31	PASK	1.21707250
32	STK38L	1.19699727
33	TLK1	1.19267778
34	CAMK1G	1.16857655
35	PRKG2	1.10609147
36	STK39	1.09654702
37	MAP2K4	1.09478908
38	BRSK2	1.08058134
39	EPHA4	1.05555222
40	FGFR1	1.04776972
41	MKNK1	1.04536704
42	PAK3	0.95575383
43	TNIK	0.91693548
44	WNK4	0.91355580
45	STK11	0.90369346
46	PINK1	0.88911099
47	ZAK	0.88675579
48	MAPK15	0.86564820
49	CDC7	0.84243640
50	ERBB2	0.83995345
51	BUB1	0.82641946
52	CAMK4	0.80946396
53	MKNK2	0.80141305
54	ADRBK1	0.79278211
55	INSRR	0.77187394
56	PHKG2	0.74989790
57	PHKG1	0.74989790
58	RPS6KA4	0.74705505
59	PLK1	0.74332054
60	TNK2	0.72596572
61	STK24	0.72467584
62	BCKDK	0.71349369
63	FRK	0.70237827
64	MAP4K2	0.68145603
65	CDK8	0.64671491
66	PRKCZ	0.63846199
67	CDK3	0.63395016
68	CSNK1G1	0.60488699
69	CAMKK2	0.59779837
70	OXSR1	0.59054833
71	PLK3	0.58852555
72	PRKCE	0.57915237
73	PRKCG	0.56166727
74	CAMK1	0.54011070
75	CCNB1	0.49257802
76	CSNK1D	0.48882459
77	PDGFRB	0.47121074
78	CSNK1G2	0.46791814
79	TEC	0.45764835
80	CAMK2A	0.45459893
81	PKN1	0.44109242
82	DYRK1A	0.42736882
83	LMTK2	0.42697606
84	PLK4	0.41694633
85	TTK	0.41535776
86	CSNK1E	0.41503806
87	FES	0.41499994
88	EPHA3	0.40741415
89	CSNK1G3	0.39902786
90	LATS2	0.39713076
91	CHEK2	0.38153711
92	NLK	0.36974039
93	PRKACA	0.36714744
94	CSNK1A1L	0.36145454
95	PRKG1	0.33335001
96	EIF2AK2	0.30715738
97	CAMK2B	0.30465161
98	YES1	0.28157158
99	MST4	0.28111442
100	PRKACG	0.27135878

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.22930329
2	Ribosome_Homo sapiens_hsa03010	3.13731204
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.12674454
4	Homologous recombination_Homo sapiens_hsa03440	3.00344783
5	Protein export_Homo sapiens_hsa03060	2.80724772
6	Basal transcription factors_Homo sapiens_hsa03022	2.78159239
7	Parkinsons disease_Homo sapiens_hsa05012	2.54056851
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.37626642
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.21527975
10	RNA polymerase_Homo sapiens_hsa03020	2.14025592
11	Phototransduction_Homo sapiens_hsa04744	1.96276286
12	RNA degradation_Homo sapiens_hsa03018	1.95717249
13	Nicotine addiction_Homo sapiens_hsa05033	1.95417167
14	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.88219289
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87704991
16	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.86948786
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82858865
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82057409
19	Huntingtons disease_Homo sapiens_hsa05016	1.73944172
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.72876899
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.72845966
22	Mismatch repair_Homo sapiens_hsa03430	1.69451858
23	Olfactory transduction_Homo sapiens_hsa04740	1.65857148
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.65732936
25	Alzheimers disease_Homo sapiens_hsa05010	1.62780913
26	Propanoate metabolism_Homo sapiens_hsa00640	1.62761950
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62099475
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34047147
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.29774845
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26540681
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.11737595
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09701514
33	Proteasome_Homo sapiens_hsa03050	1.08323456
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.03400573
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01912020
36	Axon guidance_Homo sapiens_hsa04360	1.01516722
37	Purine metabolism_Homo sapiens_hsa00230	1.00073562
38	Basal cell carcinoma_Homo sapiens_hsa05217	0.93114386
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92107398
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.90655398
41	Spliceosome_Homo sapiens_hsa03040	0.88032110
42	Taste transduction_Homo sapiens_hsa04742	0.85971358
43	Cocaine addiction_Homo sapiens_hsa05030	0.85204766
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84679709
45	RNA transport_Homo sapiens_hsa03013	0.84171251
46	Peroxisome_Homo sapiens_hsa04146	0.84130307
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.83704517
48	Serotonergic synapse_Homo sapiens_hsa04726	0.83184022
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.82281241
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82115009
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81485180
52	Butanoate metabolism_Homo sapiens_hsa00650	0.79910458
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79786101
54	Sulfur metabolism_Homo sapiens_hsa00920	0.79741805
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79164402
56	Circadian rhythm_Homo sapiens_hsa04710	0.77469561
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.77159135
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76669249
59	Morphine addiction_Homo sapiens_hsa05032	0.76137338
60	GABAergic synapse_Homo sapiens_hsa04727	0.74477512
61	DNA replication_Homo sapiens_hsa03030	0.73420521
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.72795403
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72187487
64	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69894480
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.68635648
66	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68173620
67	Circadian entrainment_Homo sapiens_hsa04713	0.67402402
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64738975
69	Hippo signaling pathway_Homo sapiens_hsa04390	0.64507269
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.63989739
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.63602605
72	Long-term depression_Homo sapiens_hsa04730	0.63234992
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.62689580
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61448905
75	Retinol metabolism_Homo sapiens_hsa00830	0.60727347
76	Caffeine metabolism_Homo sapiens_hsa00232	0.60255771
77	Cell cycle_Homo sapiens_hsa04110	0.59165324
78	Metabolic pathways_Homo sapiens_hsa01100	0.58614139
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.58552610
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.57972813
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57521607
82	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.56749207
83	Non-homologous end-joining_Homo sapiens_hsa03450	0.56280428
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.55542319
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54105605
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53662593
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52634734
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50929994
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.48736462
90	Regulation of autophagy_Homo sapiens_hsa04140	0.47499761
91	Histidine metabolism_Homo sapiens_hsa00340	0.46484683
92	ABC transporters_Homo sapiens_hsa02010	0.46412454
93	Base excision repair_Homo sapiens_hsa03410	0.46243764
94	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.45547517
95	p53 signaling pathway_Homo sapiens_hsa04115	0.44039469
96	Wnt signaling pathway_Homo sapiens_hsa04310	0.43941941
97	One carbon pool by folate_Homo sapiens_hsa00670	0.43709509
98	Gap junction_Homo sapiens_hsa04540	0.42816889
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41452210
100	Amphetamine addiction_Homo sapiens_hsa05031	0.39896904

MAPK6PS4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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