MAPK8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65247108
2neuron cell-cell adhesion (GO:0007158)5.36155829
3vocalization behavior (GO:0071625)5.21549347
4protein localization to synapse (GO:0035418)5.10415939
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06938451
6synaptic vesicle exocytosis (GO:0016079)5.06589330
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.01994875
8layer formation in cerebral cortex (GO:0021819)4.95571808
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95106314
10establishment of mitochondrion localization (GO:0051654)4.93357599
11glutamate secretion (GO:0014047)4.72947368
12synaptic vesicle maturation (GO:0016188)4.70869944
13locomotory exploration behavior (GO:0035641)4.66422187
14regulation of glutamate receptor signaling pathway (GO:1900449)4.62262903
15regulation of synaptic vesicle exocytosis (GO:2000300)4.48234950
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.42603132
17neuron recognition (GO:0008038)4.40699345
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.34450122
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21418328
20glutamate receptor signaling pathway (GO:0007215)4.20201169
21axonal fasciculation (GO:0007413)4.14392251
22positive regulation of synapse maturation (GO:0090129)4.12684404
23exploration behavior (GO:0035640)4.11058032
24synaptic transmission, glutamatergic (GO:0035249)4.08172152
25dendritic spine morphogenesis (GO:0060997)4.04841064
26pyrimidine nucleobase catabolic process (GO:0006208)3.99765877
27regulation of synaptic vesicle transport (GO:1902803)3.96867526
28neurotransmitter-gated ion channel clustering (GO:0072578)3.92924033
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91903101
30neuron-neuron synaptic transmission (GO:0007270)3.90819031
31mitochondrion transport along microtubule (GO:0047497)3.89987529
32establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.89987529
33central nervous system projection neuron axonogenesis (GO:0021952)3.86049817
34neurotransmitter secretion (GO:0007269)3.85776301
35gamma-aminobutyric acid transport (GO:0015812)3.78529142
36regulation of neuronal synaptic plasticity (GO:0048168)3.77884759
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77874434
38dendrite morphogenesis (GO:0048813)3.77398622
39postsynaptic membrane organization (GO:0001941)3.75704120
40proline transport (GO:0015824)3.70806374
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.68120010
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67096229
43cell migration in hindbrain (GO:0021535)3.63895900
44presynaptic membrane assembly (GO:0097105)3.63260585
45synaptic vesicle endocytosis (GO:0048488)3.62910544
46regulation of dendritic spine morphogenesis (GO:0061001)3.56223411
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.53561496
48neuronal action potential propagation (GO:0019227)3.50617231
49regulation of synapse structural plasticity (GO:0051823)3.46242287
50calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.42648464
51nucleobase catabolic process (GO:0046113)3.40782649
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.35946227
53regulation of synapse maturation (GO:0090128)3.35821409
54neural tube formation (GO:0001841)3.35411944
55cerebellar Purkinje cell differentiation (GO:0021702)3.34588425
56presynaptic membrane organization (GO:0097090)3.31969069
57positive regulation of membrane potential (GO:0045838)3.31724342
58long-term memory (GO:0007616)3.31288144
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29343083
60regulation of postsynaptic membrane potential (GO:0060078)3.27544716
61nerve growth factor signaling pathway (GO:0038180)3.27217747
62transmission of nerve impulse (GO:0019226)3.24798503
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.24570044
64glycosphingolipid biosynthetic process (GO:0006688)3.21753431
65synapse assembly (GO:0007416)3.20524620
66regulation of respiratory system process (GO:0044065)3.16892061
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12984120
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.12868300
69regulation of neurotransmitter secretion (GO:0046928)3.12346897
70innervation (GO:0060384)3.10742704
71neurotransmitter transport (GO:0006836)3.09415912
72behavioral defense response (GO:0002209)3.09245581
73behavioral fear response (GO:0001662)3.09245581
74behavioral response to ethanol (GO:0048149)3.08770185
75central nervous system neuron axonogenesis (GO:0021955)3.08669495
76regulation of synapse assembly (GO:0051963)3.07748861
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06361868
78regulation of dendritic spine development (GO:0060998)3.05835800
79regulation of synaptic plasticity (GO:0048167)3.04771823
80mechanosensory behavior (GO:0007638)3.04400185
81dendrite development (GO:0016358)3.01917514
82limb bud formation (GO:0060174)3.00985797
83axon extension (GO:0048675)2.99343509
84long-term synaptic potentiation (GO:0060291)2.98435158
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98316499
86organelle transport along microtubule (GO:0072384)2.97699103
87hippocampus development (GO:0021766)2.95686524
88epithelial cell differentiation involved in kidney development (GO:0035850)2.95251579
89regulation of vesicle fusion (GO:0031338)2.94173679
90startle response (GO:0001964)2.92931172
91positive regulation of neurotransmitter secretion (GO:0001956)2.92865646
92cerebellar granule cell differentiation (GO:0021707)2.92754773
93cerebral cortex radially oriented cell migration (GO:0021799)2.92665690
94vesicle transport along microtubule (GO:0047496)2.92494850
95response to histamine (GO:0034776)2.91800008
96neuron migration (GO:0001764)2.91472914
97positive regulation of synapse assembly (GO:0051965)2.89785679
98neuronal ion channel clustering (GO:0045161)2.89307812
99establishment of nucleus localization (GO:0040023)2.88037313
100learning (GO:0007612)2.87058448
101intraspecies interaction between organisms (GO:0051703)2.87004037
102social behavior (GO:0035176)2.87004037
103behavioral response to nicotine (GO:0035095)2.86582980
104synapse organization (GO:0050808)2.86292515
105retinal ganglion cell axon guidance (GO:0031290)2.85797373
106neurofilament cytoskeleton organization (GO:0060052)2.84475695
107fear response (GO:0042596)2.83996841
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82910370
109regulation of cAMP-dependent protein kinase activity (GO:2000479)2.82158884
110dendritic spine organization (GO:0097061)2.81172320
111regulation of neurotransmitter transport (GO:0051588)2.80266447
112cellular potassium ion homeostasis (GO:0030007)2.79169779
113membrane hyperpolarization (GO:0060081)2.79023202
114regulation of neurotransmitter levels (GO:0001505)2.78799926
115positive regulation of dendritic spine development (GO:0060999)2.78645333
116regulation of respiratory gaseous exchange (GO:0043576)2.76760942
117membrane depolarization (GO:0051899)2.75269078
118cerebral cortex cell migration (GO:0021795)2.74483348
119axonogenesis (GO:0007409)2.73941325
120regulation of synaptic transmission, GABAergic (GO:0032228)2.73450330
121auditory behavior (GO:0031223)2.72924662
122forebrain neuron differentiation (GO:0021879)2.72221472
123mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.71765246
124positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.71765246
125adult walking behavior (GO:0007628)2.71211332
126homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.69065361
127heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.66664365
128positive regulation of mitochondrial fission (GO:0090141)2.64329589
129response to auditory stimulus (GO:0010996)2.64221366
130neuromuscular synaptic transmission (GO:0007274)2.63099121
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61758894
132substrate-independent telencephalic tangential migration (GO:0021826)2.61184410
133substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.61184410
134negative regulation of neurotransmitter secretion (GO:0046929)2.59344602
135sympathetic nervous system development (GO:0048485)2.58921339
136cytoplasmic mRNA processing body assembly (GO:0033962)2.55706320
137nonmotile primary cilium assembly (GO:0035058)2.55009306
138regulation of synapse organization (GO:0050807)2.54608911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16317884
2GBX2_23144817_ChIP-Seq_PC3_Human3.77335396
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76594347
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63639259
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50680389
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47941446
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40918354
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40494128
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.38786542
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31115696
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31115696
12REST_21632747_ChIP-Seq_MESCs_Mouse2.30697882
13TAF15_26573619_Chip-Seq_HEK293_Human2.22009600
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19251741
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14890326
16AR_21572438_ChIP-Seq_LNCaP_Human2.13677205
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12771181
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12553815
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11104928
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03263356
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00119822
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.99313618
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.98533390
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98357617
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97133923
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94230576
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93934745
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.90356765
29* RARB_27405468_Chip-Seq_BRAIN_Mouse1.85699268
30DROSHA_22980978_ChIP-Seq_HELA_Human1.81839439
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81538190
32SMAD4_21799915_ChIP-Seq_A2780_Human1.81028875
33* FUS_26573619_Chip-Seq_HEK293_Human1.80889285
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80612418
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.79218745
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.76606897
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75289088
38P300_19829295_ChIP-Seq_ESCs_Human1.73519096
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72648474
40IGF1R_20145208_ChIP-Seq_DFB_Human1.69658143
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69330313
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.62418713
43RNF2_27304074_Chip-Seq_NSC_Mouse1.58707124
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57285069
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54580748
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53860113
47ZNF274_21170338_ChIP-Seq_K562_Hela1.51102910
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.50500138
49STAT3_23295773_ChIP-Seq_U87_Human1.47773048
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47017858
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45672215
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42768276
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42156073
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41759402
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.40706022
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.39828913
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.39647692
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39616556
59CBP_20019798_ChIP-Seq_JUKART_Human1.39616556
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38812808
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.38401512
62AR_25329375_ChIP-Seq_VCAP_Human1.38107905
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37775570
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37775570
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37559133
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31811256
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28885906
68* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27700899
69* TCF4_23295773_ChIP-Seq_U87_Human1.27492011
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26116543
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23721307
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23346890
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23142323
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22425777
75* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21828759
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21780013
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21717136
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21517102
79AR_19668381_ChIP-Seq_PC3_Human1.21210235
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20313544
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18896583
82ER_23166858_ChIP-Seq_MCF-7_Human1.18433337
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18247614
84IRF1_19129219_ChIP-ChIP_H3396_Human1.18218897
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18103738
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17965306
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.17542334
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.17437062
89* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17069994
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.15982352
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.14798484
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14553977
93EWS_26573619_Chip-Seq_HEK293_Human1.14431916
94SOX9_26525672_Chip-Seq_HEART_Mouse1.13801984
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.13100229
96JUN_21703547_ChIP-Seq_K562_Human1.13090156
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.12701382
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.12196718
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11008470
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10899804
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10786505
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10420213
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.10035527
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.09598345
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08801668
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08797239
107KDM2B_26808549_Chip-Seq_REH_Human1.08344261
108TP53_16413492_ChIP-PET_HCT116_Human1.05157815
109* FLI1_21867929_ChIP-Seq_TH2_Mouse1.04742089
110BCAT_22108803_ChIP-Seq_LS180_Human1.04689433
111AHR_22903824_ChIP-Seq_MCF-7_Human1.04199535
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02889555
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01633724
114VDR_22108803_ChIP-Seq_LS180_Human1.00831223
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.00482523
116TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99947920
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99328579
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98799596
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.98089364
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97821112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.60818884
2MP0003880_abnormal_central_pattern4.53495698
3MP0003635_abnormal_synaptic_transmissio3.80636032
4MP0004270_analgesia3.73986482
5MP0002063_abnormal_learning/memory/cond3.18114937
6MP0009745_abnormal_behavioral_response2.95718632
7MP0003787_abnormal_imprinting2.82381053
8MP0005423_abnormal_somatic_nervous2.82346489
9MP0000778_abnormal_nervous_system2.68562404
10MP0002734_abnormal_mechanical_nocicepti2.68510009
11MP0001968_abnormal_touch/_nociception2.67809154
12MP0009046_muscle_twitch2.67732176
13MP0002064_seizures2.63803060
14MP0002572_abnormal_emotion/affect_behav2.59375325
15MP0001486_abnormal_startle_reflex2.43616407
16MP0002272_abnormal_nervous_system2.17831004
17MP0002184_abnormal_innervation2.12111080
18MP0002735_abnormal_chemical_nociception2.12021388
19MP0006276_abnormal_autonomic_nervous2.01991701
20MP0001440_abnormal_grooming_behavior1.98869964
21MP0002736_abnormal_nociception_after1.97714523
22MP0002067_abnormal_sensory_capabilities1.90691204
23MP0000569_abnormal_digit_pigmentation1.86635311
24MP0002557_abnormal_social/conspecific_i1.85425742
25MP0002733_abnormal_thermal_nociception1.85063498
26MP0001984_abnormal_olfaction1.82989071
27MP0005386_behavior/neurological_phenoty1.76099403
28MP0004924_abnormal_behavior1.76099403
29MP0001501_abnormal_sleep_pattern1.72268026
30MP0001970_abnormal_pain_threshold1.71252356
31MP0004811_abnormal_neuron_physiology1.70650519
32MP0000955_abnormal_spinal_cord1.62657823
33MP0001188_hyperpigmentation1.62146246
34MP0009780_abnormal_chondrocyte_physiolo1.62116317
35MP0002882_abnormal_neuron_morphology1.54508809
36MP0005394_taste/olfaction_phenotype1.47112554
37MP0005499_abnormal_olfactory_system1.47112554
38MP0008877_abnormal_DNA_methylation1.44329099
39MP0008569_lethality_at_weaning1.43319521
40MP0003121_genomic_imprinting1.42593225
41MP0005646_abnormal_pituitary_gland1.41582693
42MP0001529_abnormal_vocalization1.39317429
43MP0002152_abnormal_brain_morphology1.37946663
44MP0002102_abnormal_ear_morphology1.33885195
45MP0002066_abnormal_motor_capabilities/c1.30945668
46MP0004885_abnormal_endolymph1.29271986
47MP0005645_abnormal_hypothalamus_physiol1.27828093
48MP0002822_catalepsy1.25248853
49MP0001502_abnormal_circadian_rhythm1.22022575
50MP0003329_amyloid_beta_deposits1.18611074
51MP0005551_abnormal_eye_electrophysiolog1.17239354
52MP0003879_abnormal_hair_cell1.16881021
53MP0008789_abnormal_olfactory_epithelium1.15717860
54MP0003122_maternal_imprinting1.15423453
55MP0003861_abnormal_nervous_system1.13352142
56MP0004858_abnormal_nervous_system1.12259626
57MP0000049_abnormal_middle_ear1.11698193
58MP0000631_abnormal_neuroendocrine_gland1.11407455
59MP0005187_abnormal_penis_morphology1.10694529
60MP0003937_abnormal_limbs/digits/tail_de1.09761615
61MP0002837_dystrophic_cardiac_calcinosis1.08501164
62MP0004742_abnormal_vestibular_system1.07899541
63MP0001905_abnormal_dopamine_level1.07077795
64MP0004133_heterotaxia1.06884643
65MP0005253_abnormal_eye_physiology1.04070739
66MP0002752_abnormal_somatic_nervous1.01370273
67MP0005248_abnormal_Harderian_gland0.99544970
68* MP0003119_abnormal_digestive_system0.99411218
69MP0003567_abnormal_fetal_cardiomyocyte0.98574476
70MP0004142_abnormal_muscle_tone0.98372777
71* MP0003221_abnormal_cardiomyocyte_apopto0.97452677
72MP0006292_abnormal_olfactory_placode0.96912931
73MP0002233_abnormal_nose_morphology0.95879805
74MP0004215_abnormal_myocardial_fiber0.95148754
75MP0002909_abnormal_adrenal_gland0.95112462
76MP0004145_abnormal_muscle_electrophysio0.93815353
77MP0001299_abnormal_eye_distance/0.93530740
78MP0006072_abnormal_retinal_apoptosis0.92543614
79MP0000751_myopathy0.91356575
80MP0003890_abnormal_embryonic-extraembry0.90183849
81MP0004085_abnormal_heartbeat0.89770751
82MP0001963_abnormal_hearing_physiology0.88432479
83MP0003631_nervous_system_phenotype0.84212316
84MP0002229_neurodegeneration0.81857145
85MP0003935_abnormal_craniofacial_develop0.81839420
86MP0001177_atelectasis0.79794341
87* MP0002069_abnormal_eating/drinking_beha0.79588378
88MP0003646_muscle_fatigue0.79037954
89MP0003633_abnormal_nervous_system0.78335171
90MP0003632_abnormal_nervous_system0.77845902
91MP0000537_abnormal_urethra_morphology0.77310276
92MP0004233_abnormal_muscle_weight0.76619289
93MP0000647_abnormal_sebaceous_gland0.76465003
94MP0004043_abnormal_pH_regulation0.75832068
95MP0008995_early_reproductive_senescence0.75119268
96* MP0001286_abnormal_eye_development0.74656109
97MP0003123_paternal_imprinting0.73892684
98MP0001293_anophthalmia0.72656938
99MP0003137_abnormal_impulse_conducting0.72377900
100MP0002697_abnormal_eye_size0.71794986
101MP0002638_abnormal_pupillary_reflex0.71071793
102* MP0005195_abnormal_posterior_eye0.70100745
103MP0005171_absent_coat_pigmentation0.69711472
104MP0000026_abnormal_inner_ear0.69511113
105MP0001485_abnormal_pinna_reflex0.67546388
106MP0002009_preneoplasia0.67148200
107MP0008057_abnormal_DNA_replication0.66927775
108MP0010386_abnormal_urinary_bladder0.66241571
109MP0005409_darkened_coat_color0.65650491
110MP0002234_abnormal_pharynx_morphology0.64516785
111MP0002081_perinatal_lethality0.63663785
112MP0003385_abnormal_body_wall0.63408634
113MP0001943_abnormal_respiration0.61457881
114MP0002751_abnormal_autonomic_nervous0.61397806
115MP0003938_abnormal_ear_development0.61060460
116* MP0002082_postnatal_lethality0.60888702
117* MP0010770_preweaning_lethality0.60888702
118MP0003698_abnormal_male_reproductive0.60691016
119* MP0010769_abnormal_survival0.58503393
120MP0003634_abnormal_glial_cell0.57649413
121MP0003755_abnormal_palate_morphology0.57029488

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.66905496
2Focal seizures (HP:0007359)4.78676020
3Epileptic encephalopathy (HP:0200134)4.61617591
4Myokymia (HP:0002411)4.56319166
5Febrile seizures (HP:0002373)4.28027757
6Progressive cerebellar ataxia (HP:0002073)4.20048180
7Visual hallucinations (HP:0002367)4.18859659
8Atonic seizures (HP:0010819)4.01953380
9Cortical dysplasia (HP:0002539)3.83743661
10Broad-based gait (HP:0002136)3.70535905
11Absence seizures (HP:0002121)3.43574136
12Hyperventilation (HP:0002883)3.42906389
13Drooling (HP:0002307)3.42208053
14Excessive salivation (HP:0003781)3.42208053
15Generalized tonic-clonic seizures (HP:0002069)3.21011543
16Genetic anticipation (HP:0003743)3.16407825
17Dialeptic seizures (HP:0011146)3.05191559
18Gaze-evoked nystagmus (HP:0000640)2.97057769
19Mutism (HP:0002300)2.91301460
20Insidious onset (HP:0003587)2.89325439
21Termporal pattern (HP:0011008)2.89325439
22Abnormality of the corticospinal tract (HP:0002492)2.85759375
23Urinary bladder sphincter dysfunction (HP:0002839)2.85434484
24Impaired vibration sensation in the lower limbs (HP:0002166)2.85272183
25Poor eye contact (HP:0000817)2.80854611
26Absent speech (HP:0001344)2.79481714
27Amblyopia (HP:0000646)2.73749982
28Fetal akinesia sequence (HP:0001989)2.71669060
29Amyotrophic lateral sclerosis (HP:0007354)2.64662854
30Supranuclear gaze palsy (HP:0000605)2.63254603
31Truncal ataxia (HP:0002078)2.57610408
32Inappropriate behavior (HP:0000719)2.56976594
33Ankle clonus (HP:0011448)2.55913128
34Papilledema (HP:0001085)2.55715289
35Epileptiform EEG discharges (HP:0011182)2.53653749
36Limb dystonia (HP:0002451)2.51213752
37Medial flaring of the eyebrow (HP:0010747)2.49867576
38Dysdiadochokinesis (HP:0002075)2.49304292
39Genital tract atresia (HP:0001827)2.48450013
40Papillary thyroid carcinoma (HP:0002895)2.47885796
41Action tremor (HP:0002345)2.46263524
42Vaginal atresia (HP:0000148)2.45522473
43EEG with generalized epileptiform discharges (HP:0011198)2.45073709
44Abnormal social behavior (HP:0012433)2.42647679
45Impaired social interactions (HP:0000735)2.42647679
46Progressive inability to walk (HP:0002505)2.42424010
47Failure to thrive in infancy (HP:0001531)2.38158183
48Urinary urgency (HP:0000012)2.35121358
49Abnormality of the lower motor neuron (HP:0002366)2.34701099
50Gait imbalance (HP:0002141)2.34176244
51Nephrogenic diabetes insipidus (HP:0009806)2.32992603
52Protruding tongue (HP:0010808)2.30616575
53Hypsarrhythmia (HP:0002521)2.29217156
54Hemiparesis (HP:0001269)2.23695832
55Dysmetria (HP:0001310)2.22357473
56Polyphagia (HP:0002591)2.20574352
57Depression (HP:0000716)2.20236201
58Spastic tetraplegia (HP:0002510)2.19748703
59Impaired smooth pursuit (HP:0007772)2.18287107
60Diplopia (HP:0000651)2.18144459
61Abnormality of binocular vision (HP:0011514)2.18144459
62Abnormality of salivation (HP:0100755)2.16656750
63Abnormal eating behavior (HP:0100738)2.16301563
64Spastic gait (HP:0002064)2.15798529
65Poor coordination (HP:0002370)2.13933324
66Thickened helices (HP:0000391)2.13785419
67Blue irides (HP:0000635)2.11620648
68Inability to walk (HP:0002540)2.11081726
69Akinesia (HP:0002304)2.10183485
70Cerebral inclusion bodies (HP:0100314)2.08570859
71Morphological abnormality of the middle ear (HP:0008609)2.03487351
72Absent eyebrow (HP:0002223)2.03125429
73Megalencephaly (HP:0001355)2.03046155
74Hypoplasia of the corpus callosum (HP:0002079)2.02620956
75Abnormality of ocular smooth pursuit (HP:0000617)2.02235430
76Curly hair (HP:0002212)2.02149350
77Abnormality of the labia minora (HP:0012880)2.01860156
78Volvulus (HP:0002580)2.00282029
79Specific learning disability (HP:0001328)1.99780459
80Stereotypic behavior (HP:0000733)1.99238443
81Agitation (HP:0000713)1.97929549
82Generalized myoclonic seizures (HP:0002123)1.96768732
83Hypoplasia of the brainstem (HP:0002365)1.96484252
84Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96484252
85Obstructive sleep apnea (HP:0002870)1.95386830
86Pheochromocytoma (HP:0002666)1.95311137
87Lissencephaly (HP:0001339)1.93934865
88Lower limb muscle weakness (HP:0007340)1.93846142
89Widely spaced teeth (HP:0000687)1.93349104
90Shoulder girdle muscle weakness (HP:0003547)1.92658596
91Retinal dysplasia (HP:0007973)1.91679131
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.91603835
93Aqueductal stenosis (HP:0002410)1.90606955
94Postural instability (HP:0002172)1.90358654
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87960343
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.87960343
97Cutaneous finger syndactyly (HP:0010554)1.87570726
98Abnormality of the musculature of the pelvis (HP:0001469)1.87557406
99Abnormality of the hip-girdle musculature (HP:0001445)1.87557406
100Impaired vibratory sensation (HP:0002495)1.87066085
101Paraplegia (HP:0010550)1.86406937
102Polymicrogyria (HP:0002126)1.84970963
103Anxiety (HP:0000739)1.84936144
104Esotropia (HP:0000565)1.84906721
105Scanning speech (HP:0002168)1.84593287
106Exotropia (HP:0000577)1.84306111
107Neurofibrillary tangles (HP:0002185)1.83948386
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83790773
109Fair hair (HP:0002286)1.82756165
110Pachygyria (HP:0001302)1.80862499
111Generalized hypopigmentation of hair (HP:0011358)1.80673709
112Gastroesophageal reflux (HP:0002020)1.78758606
113Hyperthyroidism (HP:0000836)1.77775938
114Intestinal atresia (HP:0011100)1.77550680
115Spastic paraplegia (HP:0001258)1.77276735
116Hepatoblastoma (HP:0002884)1.76973648
117Morphological abnormality of the pyramidal tract (HP:0002062)1.76959277
118Sporadic (HP:0003745)1.76586305
119Sleep apnea (HP:0010535)1.75392990
120Narrow forehead (HP:0000341)1.74254424
121Torticollis (HP:0000473)1.73941688
122Short foot (HP:0001773)1.73677270
123Cutaneous syndactyly (HP:0012725)1.73598230
124Split foot (HP:0001839)1.73531589
125Micropenis (HP:0000054)1.72794621
126Autism (HP:0000717)1.72148057
127Intellectual disability, severe (HP:0010864)1.71119631
128Labial hypoplasia (HP:0000066)1.70848094
129High anterior hairline (HP:0009890)1.70782049
130Bradykinesia (HP:0002067)1.69601658
131Midline defect of the nose (HP:0004122)1.69275701
132Cupped ear (HP:0000378)1.68997423
133Tented upper lip vermilion (HP:0010804)1.68982351
134Neuroendocrine neoplasm (HP:0100634)1.68975248
135Chronic hepatic failure (HP:0100626)1.68247199
136Optic nerve hypoplasia (HP:0000609)1.67807861
137Sacral dimple (HP:0000960)1.63743584
138Thyroid carcinoma (HP:0002890)1.63510921
139Congenital primary aphakia (HP:0007707)1.63052624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.28106942
2NTRK33.52404090
3EPHA43.47751420
4MAP3K93.46441762
5* MAP3K42.66173471
6CASK2.52088239
7MINK12.43271747
8MAPK132.34012352
9NTRK22.25559746
10PAK62.23596478
11LATS22.16256359
12* MAP2K72.02483893
13KSR12.02445627
14DAPK21.93291100
15TRIM281.85157214
16DYRK31.83267087
17PLK21.80967009
18TNIK1.76008301
19EPHA31.67159363
20KSR21.62074037
21PINK11.59142447
22SIK21.55946741
23PNCK1.55700330
24MAP3K121.55083303
25PRKD31.44310255
26* MAP2K41.41505453
27BRD41.40099716
28CDK51.37839040
29ERBB31.37286161
30DYRK21.34418432
31PHKG11.32852661
32PHKG21.32852661
33CSNK1G21.26785008
34SRPK11.23302107
35TYRO31.15759856
36DAPK11.12515248
37GRK51.05927217
38STK381.04287095
39DYRK1A1.03764010
40PRKCG1.01786530
41CDK190.96548208
42UHMK10.96388926
43RPS6KA40.96179524
44CAMKK10.94994754
45NTRK10.94938188
46RIPK40.94890683
47BMPR20.91919953
48CAMK2A0.91163193
49CDK180.90965407
50SGK20.87996227
51CDK150.87963973
52SGK4940.87085275
53SGK2230.87085275
54CAMKK20.86155415
55DYRK1B0.85986837
56CDK140.85915303
57TAOK10.84297027
58STK110.83638931
59FES0.83434921
60LATS10.81194964
61PAK30.79804722
62MARK20.76673568
63PRPF4B0.75636657
64CDK11A0.75300693
65RAF10.74996847
66CDK30.71598334
67BMPR1B0.67359317
68BCR0.67058492
69SGK10.66966389
70MKNK10.65583696
71CSNK1G30.65529232
72MAP4K20.65311052
73PKN10.64885340
74CAMK40.62887644
75CSNK1A1L0.62361386
76ERBB40.62092408
77MAP3K20.61888986
78ADRBK20.61500041
79WNK30.58764455
80CAMK2B0.57929655
81ARAF0.57620600
82OXSR10.57461255
83WNK40.57225185
84FGFR20.56697048
85AKT30.55994355
86CSNK1D0.55339242
87SGK30.54356695
88PRKCE0.53301955
89PLK40.52636169
90MAPK100.51353467
91CSNK1E0.50744694
92PRKCZ0.49886129
93SIK30.49630557
94MKNK20.48849957
95BRAF0.48674731
96FGR0.48504350
97CHEK20.48105605
98CAMK10.47928918
99CCNB10.46968970
100EPHB20.46946980
101CAMK1G0.46380160
102FER0.46257005
103RPS6KA30.45911115
104CDK80.44165526
105PLK30.43881344
106ALK0.43623557
107ZAK0.42339341
108CSNK1G10.42094554
109FRK0.41503138
110MAPK120.41369812
111MAP3K130.40997270
112ERBB20.39967133
113RPS6KA20.39599450
114PTK2B0.39571099
115MAP3K100.39183403
116STK38L0.38640630
117PRKAA10.38215802
118YES10.37917629
119STK390.37028784
120PRKACB0.36805708
121ADRBK10.36679247
122MAPK80.36110773
123* GSK3B0.35877336
124CDK90.35422226
125PRKG10.34554321
126PRKACA0.32608290
127OBSCN0.31272405
128EGFR0.30851581
129MUSK0.30789309

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.91435859
2Synaptic vesicle cycle_Homo sapiens_hsa047213.01632214
3* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73397778
4GABAergic synapse_Homo sapiens_hsa047272.69360696
5Glutamatergic synapse_Homo sapiens_hsa047242.63284195
6Circadian entrainment_Homo sapiens_hsa047132.60148763
7Olfactory transduction_Homo sapiens_hsa047402.58605534
8Morphine addiction_Homo sapiens_hsa050322.57851612
9Long-term potentiation_Homo sapiens_hsa047202.53504032
10Amphetamine addiction_Homo sapiens_hsa050312.25689804
11* Dopaminergic synapse_Homo sapiens_hsa047282.25105045
12Cholinergic synapse_Homo sapiens_hsa047251.94995284
13Serotonergic synapse_Homo sapiens_hsa047261.93918949
14Long-term depression_Homo sapiens_hsa047301.88303189
15Taste transduction_Homo sapiens_hsa047421.85869582
16Salivary secretion_Homo sapiens_hsa049701.81066238
17Axon guidance_Homo sapiens_hsa043601.73150786
18Insulin secretion_Homo sapiens_hsa049111.72094905
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67849344
20Renin secretion_Homo sapiens_hsa049241.64936423
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62613413
22Oxytocin signaling pathway_Homo sapiens_hsa049211.61930697
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52708575
24Gastric acid secretion_Homo sapiens_hsa049711.46945638
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46348717
26Cocaine addiction_Homo sapiens_hsa050301.45764990
27Calcium signaling pathway_Homo sapiens_hsa040201.41069654
28Gap junction_Homo sapiens_hsa045401.39851680
29* GnRH signaling pathway_Homo sapiens_hsa049121.39715931
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39241888
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35104482
32Oocyte meiosis_Homo sapiens_hsa041141.32552615
33Phototransduction_Homo sapiens_hsa047441.29387304
34Glioma_Homo sapiens_hsa052141.28041844
35Steroid biosynthesis_Homo sapiens_hsa001001.26808374
36Estrogen signaling pathway_Homo sapiens_hsa049151.24959185
37* ErbB signaling pathway_Homo sapiens_hsa040121.23222342
38* cAMP signaling pathway_Homo sapiens_hsa040241.22173290
39* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22071674
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16832153
41Melanogenesis_Homo sapiens_hsa049161.13184995
42Butanoate metabolism_Homo sapiens_hsa006501.12564305
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11634124
44Dorso-ventral axis formation_Homo sapiens_hsa043201.08122495
45Collecting duct acid secretion_Homo sapiens_hsa049661.07644002
46Basal transcription factors_Homo sapiens_hsa030221.07631111
47* Type II diabetes mellitus_Homo sapiens_hsa049301.04628451
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04279791
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03566325
50Endometrial cancer_Homo sapiens_hsa052130.91664136
51* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86648110
52Circadian rhythm_Homo sapiens_hsa047100.85544642
53* Colorectal cancer_Homo sapiens_hsa052100.83301039
54* Choline metabolism in cancer_Homo sapiens_hsa052310.82666558
55* MAPK signaling pathway_Homo sapiens_hsa040100.82110474
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80686619
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.80526310
58Ether lipid metabolism_Homo sapiens_hsa005650.79230537
59Renal cell carcinoma_Homo sapiens_hsa052110.78608016
60Regulation of autophagy_Homo sapiens_hsa041400.77542779
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.77445210
62Alcoholism_Homo sapiens_hsa050340.77128256
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76322898
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76322633
65Basal cell carcinoma_Homo sapiens_hsa052170.75918199
66VEGF signaling pathway_Homo sapiens_hsa043700.73975675
67* Wnt signaling pathway_Homo sapiens_hsa043100.73794419
68mTOR signaling pathway_Homo sapiens_hsa041500.73283099
69* Ras signaling pathway_Homo sapiens_hsa040140.72174731
70Cardiac muscle contraction_Homo sapiens_hsa042600.69566091
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68546258
72Dilated cardiomyopathy_Homo sapiens_hsa054140.67883048
73Ovarian steroidogenesis_Homo sapiens_hsa049130.67798387
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67466996
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66509810
76Non-small cell lung cancer_Homo sapiens_hsa052230.66315719
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64556013
78AMPK signaling pathway_Homo sapiens_hsa041520.64031896
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62993430
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62088723
81* Neurotrophin signaling pathway_Homo sapiens_hsa047220.60603347
82Adherens junction_Homo sapiens_hsa045200.60300562
83Glucagon signaling pathway_Homo sapiens_hsa049220.60050974
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58365128
85Vibrio cholerae infection_Homo sapiens_hsa051100.58355667
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57114746
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56979738
88Rap1 signaling pathway_Homo sapiens_hsa040150.55675923
89Thyroid hormone synthesis_Homo sapiens_hsa049180.54736041
90* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54190342
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52435448
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51844478
93* Prolactin signaling pathway_Homo sapiens_hsa049170.51836776
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48382683
95* Sphingolipid signaling pathway_Homo sapiens_hsa040710.47978408
96Hippo signaling pathway_Homo sapiens_hsa043900.47408071
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47293516
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46476788
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46445954
100Pancreatic secretion_Homo sapiens_hsa049720.45368784
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45216380
102Inositol phosphate metabolism_Homo sapiens_hsa005620.44417327
103* Insulin signaling pathway_Homo sapiens_hsa049100.43828918
104Hedgehog signaling pathway_Homo sapiens_hsa043400.43814985
105Melanoma_Homo sapiens_hsa052180.41878415
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41558981
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41254020
108Linoleic acid metabolism_Homo sapiens_hsa005910.40086111
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37684331
110RNA degradation_Homo sapiens_hsa030180.37015273
111* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35650504
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35352257
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34650142
114mRNA surveillance pathway_Homo sapiens_hsa030150.33740723
115Endocytosis_Homo sapiens_hsa041440.32423543
116Tight junction_Homo sapiens_hsa045300.32076769
117* Pancreatic cancer_Homo sapiens_hsa052120.31651626
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31019440

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