MAPK8IP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.16941700
2synaptic vesicle maturation (GO:0016188)5.84194236
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.76639552
4locomotory exploration behavior (GO:0035641)5.45176586
5synaptic vesicle exocytosis (GO:0016079)5.39180905
6vocalization behavior (GO:0071625)5.33873946
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.24691639
8regulation of synaptic vesicle exocytosis (GO:2000300)5.06344391
9glutamate secretion (GO:0014047)4.97631175
10cerebellar granule cell differentiation (GO:0021707)4.77354447
11protein localization to synapse (GO:0035418)4.70391900
12* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.68686437
13neuron cell-cell adhesion (GO:0007158)4.59947381
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.57699027
15neurotransmitter secretion (GO:0007269)4.54911590
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.53125891
17neuronal action potential propagation (GO:0019227)4.52664445
18regulation of synaptic vesicle transport (GO:1902803)4.50793880
19* regulation of glutamate receptor signaling pathway (GO:1900449)4.47067874
20L-amino acid import (GO:0043092)4.44373346
21exploration behavior (GO:0035640)4.42937572
22central nervous system myelination (GO:0022010)4.40868576
23axon ensheathment in central nervous system (GO:0032291)4.40868576
24regulation of neuronal synaptic plasticity (GO:0048168)4.29505902
25layer formation in cerebral cortex (GO:0021819)4.26206714
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.18057723
27glutamate receptor signaling pathway (GO:0007215)4.11765271
28synaptic transmission, glutamatergic (GO:0035249)4.08997431
29regulation of synapse structural plasticity (GO:0051823)4.08636905
30potassium ion homeostasis (GO:0055075)4.06537436
31cellular potassium ion homeostasis (GO:0030007)4.01532703
32potassium ion import (GO:0010107)3.96405507
33amino acid import (GO:0043090)3.95526461
34dendritic spine morphogenesis (GO:0060997)3.92485231
35proline transport (GO:0015824)3.92383111
36regulation of synapse maturation (GO:0090128)3.92156937
37gamma-aminobutyric acid transport (GO:0015812)3.90259167
38neuron-neuron synaptic transmission (GO:0007270)3.89656538
39regulation of voltage-gated calcium channel activity (GO:1901385)3.82895498
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.78735863
41neurotransmitter transport (GO:0006836)3.76257683
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76239133
43long-term memory (GO:0007616)3.76127037
44activation of protein kinase A activity (GO:0034199)3.71144120
45sodium ion export (GO:0071436)3.67678880
46neuron recognition (GO:0008038)3.62818207
47neurotransmitter-gated ion channel clustering (GO:0072578)3.61934813
48cerebellar Purkinje cell differentiation (GO:0021702)3.60611213
49synaptic vesicle endocytosis (GO:0048488)3.59394740
50positive regulation of membrane potential (GO:0045838)3.58771279
51regulation of ARF protein signal transduction (GO:0032012)3.57047287
52positive regulation of synapse maturation (GO:0090129)3.55417232
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54985809
54cellular sodium ion homeostasis (GO:0006883)3.54885199
55transmission of nerve impulse (GO:0019226)3.54850341
56neuromuscular process controlling posture (GO:0050884)3.48613056
57* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48461256
58* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48345632
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46717229
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.46433384
61negative regulation of dendrite morphogenesis (GO:0050774)3.45942367
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45444228
63regulation of neurotransmitter secretion (GO:0046928)3.44609248
64regulation of neurotransmitter levels (GO:0001505)3.44557342
65regulation of vesicle fusion (GO:0031338)3.42307204
66regulation of dendritic spine development (GO:0060998)3.40187613
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.39207923
68regulation of synaptic plasticity (GO:0048167)3.38440990
69membrane depolarization during action potential (GO:0086010)3.38173171
70presynaptic membrane organization (GO:0097090)3.36980016
71neuromuscular process controlling balance (GO:0050885)3.36839406
72dendritic spine organization (GO:0097061)3.36292038
73* regulation of postsynaptic membrane potential (GO:0060078)3.35914854
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33453641
75neuromuscular synaptic transmission (GO:0007274)3.33440480
76axonal fasciculation (GO:0007413)3.32626794
77cell communication by electrical coupling (GO:0010644)3.29202498
78cell differentiation in hindbrain (GO:0021533)3.28080973
79innervation (GO:0060384)3.24723605
80regulation of dendritic spine morphogenesis (GO:0061001)3.24635392
81glycine transport (GO:0015816)3.23244248
82prepulse inhibition (GO:0060134)3.22083739
83neurotransmitter uptake (GO:0001504)3.21584387
84regulation of neurotransmitter transport (GO:0051588)3.20519094
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20384140
86synaptic vesicle transport (GO:0048489)3.17853298
87establishment of synaptic vesicle localization (GO:0097480)3.17853298
88presynaptic membrane assembly (GO:0097105)3.16988280
89auditory behavior (GO:0031223)3.16736635
90long-term synaptic potentiation (GO:0060291)3.15740211
91acidic amino acid transport (GO:0015800)3.15416000
92membrane hyperpolarization (GO:0060081)3.13279459
93cell migration in hindbrain (GO:0021535)3.12395588
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12187389
95response to auditory stimulus (GO:0010996)3.11844509
96postsynaptic membrane organization (GO:0001941)3.10961422
97establishment of mitochondrion localization (GO:0051654)3.10749355
98vesicle transport along microtubule (GO:0047496)3.10682611
99* membrane depolarization (GO:0051899)3.09803259
100synapse assembly (GO:0007416)3.08278561
101negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08065928
102response to pheromone (GO:0019236)3.05821690
103* regulation of synaptic transmission, glutamatergic (GO:0051966)3.05347108
104neuronal ion channel clustering (GO:0045161)3.05157497
105positive regulation of neurotransmitter transport (GO:0051590)3.05151659
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03809614
107synaptic transmission (GO:0007268)3.02244526
108regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.02174999
109negative regulation of microtubule polymerization (GO:0031115)3.01177955
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99361456
111positive regulation of neurotransmitter secretion (GO:0001956)2.96551627
112* dendrite morphogenesis (GO:0048813)2.95767660
113positive regulation of dendritic spine development (GO:0060999)2.93191014
114cerebellar Purkinje cell layer development (GO:0021680)2.91990357
115detection of calcium ion (GO:0005513)2.91835161
116chemosensory behavior (GO:0007635)2.91753581
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.91710914
118G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91148441
119neuromuscular process (GO:0050905)2.90434058
120* regulation of synaptic transmission (GO:0050804)2.90115250
121* learning (GO:0007612)2.89779283
122response to histamine (GO:0034776)2.89320746
123organelle transport along microtubule (GO:0072384)2.89181030
124regulation of calcium ion-dependent exocytosis (GO:0017158)2.87947299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.43817731
2GBX2_23144817_ChIP-Seq_PC3_Human3.27017302
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10182576
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07224526
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04631439
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.94462271
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74193912
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74193912
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72163870
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.59744448
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58579029
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56847748
13DROSHA_22980978_ChIP-Seq_HELA_Human2.56759752
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55469924
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.51982807
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50599323
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44687439
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.39975801
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33580311
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32990317
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.26403175
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25747576
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23760825
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22625381
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21813054
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.19849954
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98193356
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96094460
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86611082
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83240786
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71757527
32TAF15_26573619_Chip-Seq_HEK293_Human1.70677054
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.61708894
34SMAD4_21799915_ChIP-Seq_A2780_Human1.59229764
35AR_21572438_ChIP-Seq_LNCaP_Human1.58076494
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57509335
37ZNF274_21170338_ChIP-Seq_K562_Hela1.53931565
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51309515
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40410572
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36618183
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35977114
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.35909389
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32782303
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31738543
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31620372
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28694566
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27022244
48* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26913013
49P300_19829295_ChIP-Seq_ESCs_Human1.24599177
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23086088
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.22246381
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20813377
53IGF1R_20145208_ChIP-Seq_DFB_Human1.20086300
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.18856211
55* AR_19668381_ChIP-Seq_PC3_Human1.18841304
56STAT3_23295773_ChIP-Seq_U87_Human1.17419167
57AR_25329375_ChIP-Seq_VCAP_Human1.16901133
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16202696
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14743801
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14316028
61RNF2_27304074_Chip-Seq_NSC_Mouse1.12954650
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.11702615
63* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11529548
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11285794
65KDM2B_26808549_Chip-Seq_K562_Human1.11214830
66* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09113181
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08753492
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.08532270
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07720503
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07172806
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06097555
72* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04984839
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04608541
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03996465
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.03651573
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02744124
77OCT4_19829295_ChIP-Seq_ESCs_Human1.02605039
78TCF4_23295773_ChIP-Seq_U87_Human1.01897687
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.01441441
80* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01418825
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01275651
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00991290
83* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00462177
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99589055
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98947942
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.97760893
87LXR_22292898_ChIP-Seq_THP-1_Human0.96787313
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94420495
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.94260381
90RUNX2_22187159_ChIP-Seq_PCA_Human0.93194614
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92581740
92AHR_22903824_ChIP-Seq_MCF-7_Human0.91756268
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.90724853
94* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90566102
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90209858
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90080100
97CTCF_27219007_Chip-Seq_Bcells_Human0.90067744
98DPY_21335234_ChIP-Seq_ESCs_Mouse0.89674037
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.89205344
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89004268
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.88012896
102TET1_21490601_ChIP-Seq_MESCs_Mouse0.87654664
103SMC4_20622854_ChIP-Seq_HELA_Human0.87574345
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87558624
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86935283
106KLF4_19829295_ChIP-Seq_ESCs_Human0.85499452
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85092927
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85063786
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84867946
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84675323
111VDR_22108803_ChIP-Seq_LS180_Human0.84522723
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84286946
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84200798
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83715597
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83662180
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83599507
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82279848
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81955678
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.81615791
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80765539
121RUNX1_26923725_Chip-Seq_HPCs_Mouse0.78788065
122CREB1_26743006_Chip-Seq_LNCaP_Human0.78270004
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76877634
124SMAD4_21741376_ChIP-Seq_ESCs_Human0.76510057
125P68_20966046_ChIP-Seq_HELA_Human0.75138038
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74817374
127NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.72574063
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71196034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.10854411
2MP0003880_abnormal_central_pattern4.62893184
3* MP0003635_abnormal_synaptic_transmissio4.04409148
4MP0004270_analgesia3.69720281
5MP0009745_abnormal_behavioral_response3.30319035
6* MP0002063_abnormal_learning/memory/cond3.18145601
7MP0009046_muscle_twitch3.10477813
8MP0001968_abnormal_touch/_nociception3.09106178
9MP0002064_seizures3.08594863
10MP0005423_abnormal_somatic_nervous2.93217309
11MP0002734_abnormal_mechanical_nocicepti2.79329144
12MP0002822_catalepsy2.76203494
13* MP0002572_abnormal_emotion/affect_behav2.69558459
14MP0002272_abnormal_nervous_system2.64680329
15MP0002735_abnormal_chemical_nociception2.47978680
16MP0001486_abnormal_startle_reflex2.44652938
17MP0002736_abnormal_nociception_after2.35594444
18MP0001501_abnormal_sleep_pattern2.27184357
19MP0002733_abnormal_thermal_nociception2.22859513
20MP0006276_abnormal_autonomic_nervous2.15451986
21MP0001440_abnormal_grooming_behavior2.13110087
22MP0001970_abnormal_pain_threshold2.11522475
23MP0001984_abnormal_olfaction2.03467912
24MP0002067_abnormal_sensory_capabilities2.02417423
25MP0002909_abnormal_adrenal_gland2.02104529
26MP0002184_abnormal_innervation2.01978874
27MP0004858_abnormal_nervous_system1.89959410
28MP0008569_lethality_at_weaning1.88915481
29MP0003329_amyloid_beta_deposits1.81868303
30MP0004811_abnormal_neuron_physiology1.80070083
31MP0009780_abnormal_chondrocyte_physiolo1.79256309
32MP0000778_abnormal_nervous_system1.76505362
33* MP0002557_abnormal_social/conspecific_i1.74079292
34MP0004924_abnormal_behavior1.72086251
35MP0005386_behavior/neurological_phenoty1.72086251
36MP0005645_abnormal_hypothalamus_physiol1.68751407
37MP0000955_abnormal_spinal_cord1.65132868
38MP0005646_abnormal_pituitary_gland1.58012782
39MP0003123_paternal_imprinting1.57760839
40* MP0002882_abnormal_neuron_morphology1.47193265
41MP0003879_abnormal_hair_cell1.45950165
42MP0003122_maternal_imprinting1.44354394
43MP0001529_abnormal_vocalization1.41510029
44* MP0002066_abnormal_motor_capabilities/c1.41344620
45MP0003787_abnormal_imprinting1.38680277
46MP0001502_abnormal_circadian_rhythm1.36697363
47MP0004885_abnormal_endolymph1.30932662
48MP0003633_abnormal_nervous_system1.29107020
49MP0001905_abnormal_dopamine_level1.28747307
50MP0004142_abnormal_muscle_tone1.26791355
51MP0010386_abnormal_urinary_bladder1.24117917
52MP0003283_abnormal_digestive_organ1.16687194
53MP0005551_abnormal_eye_electrophysiolog1.11840640
54* MP0002152_abnormal_brain_morphology1.10384086
55MP0004145_abnormal_muscle_electrophysio1.09102437
56MP0003631_nervous_system_phenotype1.08908439
57MP0002229_neurodegeneration1.08254471
58MP0005394_taste/olfaction_phenotype1.07657493
59MP0005499_abnormal_olfactory_system1.07657493
60MP0000013_abnormal_adipose_tissue1.04998750
61MP0002638_abnormal_pupillary_reflex1.00826779
62MP0001188_hyperpigmentation0.98713139
63MP0008872_abnormal_physiological_respon0.98028900
64MP0001346_abnormal_lacrimal_gland0.96005500
65MP0002069_abnormal_eating/drinking_beha0.95720601
66MP0000751_myopathy0.95617762
67MP0003634_abnormal_glial_cell0.88078960
68MP0004742_abnormal_vestibular_system0.87637195
69MP0005535_abnormal_body_temperature0.87574874
70MP0001348_abnormal_lacrimal_gland0.87273472
71MP0002752_abnormal_somatic_nervous0.86693841
72MP0008877_abnormal_DNA_methylation0.86647887
73MP0008961_abnormal_basal_metabolism0.85788607
74MP0000569_abnormal_digit_pigmentation0.85632899
75MP0000631_abnormal_neuroendocrine_gland0.85307633
76MP0006072_abnormal_retinal_apoptosis0.84525441
77MP0004085_abnormal_heartbeat0.81465397
78MP0002837_dystrophic_cardiac_calcinosis0.81446900
79MP0003121_genomic_imprinting0.79178024
80MP0008874_decreased_physiological_sensi0.78979573
81MP0001963_abnormal_hearing_physiology0.77690333
82MP0003632_abnormal_nervous_system0.77638611
83MP0004147_increased_porphyrin_level0.75567041
84MP0005167_abnormal_blood-brain_barrier0.75475403
85MP0000604_amyloidosis0.75132863
86MP0000566_synostosis0.74498831
87MP0001177_atelectasis0.74104081
88MP0001986_abnormal_taste_sensitivity0.73046296
89MP0002090_abnormal_vision0.72976564
90MP0000920_abnormal_myelination0.66947158
91MP0003690_abnormal_glial_cell0.65225109
92MP0004043_abnormal_pH_regulation0.64144186
93MP0000579_abnormal_nail_morphology0.63761923
94MP0001664_abnormal_digestion0.63338364
95MP0004130_abnormal_muscle_cell0.63316614
96MP0005187_abnormal_penis_morphology0.62828941
97MP0000026_abnormal_inner_ear0.61959686
98MP0001299_abnormal_eye_distance/0.61891429
99MP0003137_abnormal_impulse_conducting0.61135677
100MP0004215_abnormal_myocardial_fiber0.61133747
101MP0004233_abnormal_muscle_weight0.60494367
102MP0002653_abnormal_ependyma_morphology0.59837273
103MP0003075_altered_response_to0.59486959
104MP0003938_abnormal_ear_development0.58045286
105MP0003861_abnormal_nervous_system0.57993282
106MP0001485_abnormal_pinna_reflex0.57473277
107MP0005253_abnormal_eye_physiology0.56540160
108MP0010770_preweaning_lethality0.55962219
109MP0002082_postnatal_lethality0.55962219
110MP0010768_mortality/aging0.55784831
111MP0001943_abnormal_respiration0.55135052
112MP0005410_abnormal_fertilization0.54966999
113MP0005623_abnormal_meninges_morphology0.54603288
114MP0002751_abnormal_autonomic_nervous0.54181204
115MP0002876_abnormal_thyroid_physiology0.54069095
116MP0005409_darkened_coat_color0.53525262
117MP0002249_abnormal_larynx_morphology0.53080603
118MP0010769_abnormal_survival0.52707535
119* MP0003956_abnormal_body_size0.49503685
120MP0004133_heterotaxia0.46240389

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.00003488
2Myokymia (HP:0002411)6.90046917
3Focal seizures (HP:0007359)5.56106287
4Visual hallucinations (HP:0002367)5.51901728
5Atonic seizures (HP:0010819)4.62020849
6Progressive cerebellar ataxia (HP:0002073)4.48341144
7Febrile seizures (HP:0002373)4.40025532
8Epileptic encephalopathy (HP:0200134)4.38150373
9Action tremor (HP:0002345)4.28066635
10Absence seizures (HP:0002121)4.18847820
11Supranuclear gaze palsy (HP:0000605)3.94162209
12Generalized tonic-clonic seizures (HP:0002069)3.81095037
13Dialeptic seizures (HP:0011146)3.77193182
14Ankle clonus (HP:0011448)3.49217318
15Cerebral hypomyelination (HP:0006808)3.42917309
16Depression (HP:0000716)3.33903843
17Obstructive sleep apnea (HP:0002870)3.27859015
18Tetraplegia (HP:0002445)3.22379762
19Broad-based gait (HP:0002136)3.14529192
20Gaze-evoked nystagmus (HP:0000640)3.12724674
21Truncal ataxia (HP:0002078)3.11601993
22Anxiety (HP:0000739)3.11181235
23Poor eye contact (HP:0000817)3.06855055
24Impaired vibration sensation in the lower limbs (HP:0002166)3.06215746
25Dysdiadochokinesis (HP:0002075)3.05812971
26Akinesia (HP:0002304)3.03983390
27Amblyopia (HP:0000646)3.01981513
28Mutism (HP:0002300)2.99737903
29Dysmetria (HP:0001310)2.92938238
30Abnormality of the lower motor neuron (HP:0002366)2.89945431
31Abnormal eating behavior (HP:0100738)2.89107736
32Urinary bladder sphincter dysfunction (HP:0002839)2.88713537
33Papilledema (HP:0001085)2.87592177
34Limb dystonia (HP:0002451)2.84278630
35Impaired social interactions (HP:0000735)2.81247047
36Abnormal social behavior (HP:0012433)2.81247047
37Postural instability (HP:0002172)2.79793591
38Hemiparesis (HP:0001269)2.74528796
39Pheochromocytoma (HP:0002666)2.70857723
40Sleep apnea (HP:0010535)2.70236821
41Impaired smooth pursuit (HP:0007772)2.66482682
42Progressive inability to walk (HP:0002505)2.56301608
43Urinary urgency (HP:0000012)2.55192191
44Spastic gait (HP:0002064)2.54537839
45Agitation (HP:0000713)2.54443250
46Genetic anticipation (HP:0003743)2.53066874
47Drooling (HP:0002307)2.52204606
48Excessive salivation (HP:0003781)2.52204606
49Torticollis (HP:0000473)2.51319844
50Cerebral inclusion bodies (HP:0100314)2.49013114
51Epileptiform EEG discharges (HP:0011182)2.48760576
52Ventricular fibrillation (HP:0001663)2.48506916
53Hyperventilation (HP:0002883)2.47256294
54Bradykinesia (HP:0002067)2.45916618
55EEG with generalized epileptiform discharges (HP:0011198)2.44757935
56Neurofibrillary tangles (HP:0002185)2.44062489
57Spastic tetraparesis (HP:0001285)2.43550214
58Scanning speech (HP:0002168)2.41244272
59Apathy (HP:0000741)2.37147951
60Intention tremor (HP:0002080)2.36869053
61Insidious onset (HP:0003587)2.36307211
62Termporal pattern (HP:0011008)2.36307211
63Abnormality of ocular smooth pursuit (HP:0000617)2.35935223
64Focal dystonia (HP:0004373)2.35471653
65Peripheral hypomyelination (HP:0007182)2.34832436
66Diplopia (HP:0000651)2.34422340
67Abnormality of binocular vision (HP:0011514)2.34422340
68Hemiplegia (HP:0002301)2.32199395
69Hypsarrhythmia (HP:0002521)2.32085856
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31953444
71Morphological abnormality of the pyramidal tract (HP:0002062)2.30283438
72Neuroendocrine neoplasm (HP:0100634)2.29669233
73Choreoathetosis (HP:0001266)2.24024269
74Insomnia (HP:0100785)2.23000120
75CNS hypomyelination (HP:0003429)2.21836348
76Abnormality of the corticospinal tract (HP:0002492)2.20236914
77Megalencephaly (HP:0001355)2.19418362
78Stereotypic behavior (HP:0000733)2.19216179
79Lower limb muscle weakness (HP:0007340)2.13021476
80Diminished motivation (HP:0000745)2.12668146
81Dysmetric saccades (HP:0000641)2.11773725
82Polyphagia (HP:0002591)2.11233056
83Craniofacial dystonia (HP:0012179)2.11066945
84Failure to thrive in infancy (HP:0001531)2.10641024
85Status epilepticus (HP:0002133)2.06689925
86Fetal akinesia sequence (HP:0001989)2.04230795
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04034195
88Degeneration of the lateral corticospinal tracts (HP:0002314)2.04034195
89Absent speech (HP:0001344)2.03818225
90Amyotrophic lateral sclerosis (HP:0007354)2.03619565
91Impaired vibratory sensation (HP:0002495)2.01581574
92Increased circulating renin level (HP:0000848)1.97115672
93Clonus (HP:0002169)1.95299842
94Annular pancreas (HP:0001734)1.95116144
95Hypoventilation (HP:0002791)1.94663765
96Neuronal loss in central nervous system (HP:0002529)1.93456685
97Gait ataxia (HP:0002066)1.93160397
98Postural tremor (HP:0002174)1.92622619
99Psychosis (HP:0000709)1.91989001
100Pointed chin (HP:0000307)1.91956585
101Gait imbalance (HP:0002141)1.91656658
102Delusions (HP:0000746)1.90393769
103Generalized myoclonic seizures (HP:0002123)1.88299730
104Spinal canal stenosis (HP:0003416)1.87450589
105Inability to walk (HP:0002540)1.87225959
106Specific learning disability (HP:0001328)1.85025679
107Abnormal EKG (HP:0003115)1.83550530
108Rapidly progressive (HP:0003678)1.83492744
109Aplasia involving bones of the upper limbs (HP:0009823)1.82443911
110Aplasia of the phalanges of the hand (HP:0009802)1.82443911
111Aplasia involving bones of the extremities (HP:0009825)1.82443911
112Incomplete penetrance (HP:0003829)1.81658898
113Lower limb asymmetry (HP:0100559)1.79766546
114Hypercortisolism (HP:0001578)1.78680698
115Rigidity (HP:0002063)1.77452608
116Abnormality of saccadic eye movements (HP:0000570)1.76198827
117Blue irides (HP:0000635)1.75469133
118Spastic tetraplegia (HP:0002510)1.75363179
119Prolonged QT interval (HP:0001657)1.75187723
120Retinal dysplasia (HP:0007973)1.74409422
121Central scotoma (HP:0000603)1.74086145
122Neoplasm of the peripheral nervous system (HP:0100007)1.73976719
123Unsteady gait (HP:0002317)1.70839891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.63790197
2MAP3K93.78698963
3EPHA43.64156206
4MARK13.25927454
5MAP3K43.15961914
6MINK12.93385454
7MAP2K72.53837123
8PAK62.28871892
9PRKD32.24615381
10DAPK22.20603288
11NTRK12.17526747
12NTRK22.14132838
13MAP3K122.08448408
14KSR22.08402062
15MAP2K41.99032582
16CAMKK11.83494039
17RIPK41.72359896
18PNCK1.69703326
19GRK51.63417971
20CDK51.57081310
21STK381.48236259
22KSR11.43277417
23SIK21.41908625
24MAPK131.40936089
25UHMK11.39762339
26ARAF1.39026548
27MAP3K21.36711632
28PHKG11.34736294
29PHKG21.34736294
30DAPK11.33270709
31CASK1.31815704
32PRKCG1.27000682
33TNIK1.26113409
34PLK21.25661924
35CAMKK21.24779116
36FES1.16850005
37CDK191.16645582
38PRPF4B1.12649770
39TYRO31.05405698
40LATS21.02753455
41CAMK2A0.97557058
42LMTK20.92819307
43SGK4940.92580563
44SGK2230.92580563
45PKN10.92497099
46RET0.91465893
47PINK10.90846647
48CDK180.90622932
49CDK150.89432570
50CDK140.89287571
51NEK60.89271219
52STK110.85957854
53PAK30.85884377
54CAMK10.84796515
55PRKCH0.84012959
56CAMK2B0.83943648
57MAP3K110.79725155
58CDK11A0.78827200
59MAP3K130.78558456
60DYRK1A0.76018090
61MAPK120.75018852
62CSNK1G20.74445300
63FGFR20.74440080
64TAOK10.74210402
65MAP2K60.73150664
66WNK10.69626324
67ALK0.69208228
68SGK20.68907652
69PTK2B0.68300256
70TNK20.66095458
71MARK20.65538971
72MAP3K10.65426291
73BMPR20.64799097
74RAF10.60542431
75CAMK2D0.59183853
76SGK10.58637796
77FER0.58537780
78CDC42BPA0.58253213
79SGK30.58076146
80CAMK1G0.56992236
81NME10.56757507
82WNK30.55551544
83LIMK10.54938635
84SCYL20.54206944
85DYRK20.53418513
86DAPK30.51942235
87CAMK2G0.51783526
88OXSR10.51203867
89PRKCZ0.50915384
90PRKCE0.50176192
91PDK10.50013575
92RPS6KA30.48807927
93PDPK10.47465079
94MAPK100.47046027
95CAMK1D0.46976264
96RPS6KA20.45444038
97BRSK10.43847831
98RIPK10.43676621
99MAP2K10.43486824
100FYN0.42386109
101ERBB20.41539606
102ICK0.40966178
103CAMK40.37387446
104NEK10.36453228
105TAOK20.35312264
106WNK40.34717794
107PRKCB0.33640697
108BRAF0.32351381
109MAPK80.32260816
110CSNK1E0.31629731
111FGR0.31477018
112PRKACA0.30803818
113MAPKAPK50.29866722
114ROCK20.29074596
115PRKCA0.28724591
116CSNK1D0.26873410
117IRAK20.26604375

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69853995
2Synaptic vesicle cycle_Homo sapiens_hsa047213.43586296
3Olfactory transduction_Homo sapiens_hsa047402.92513545
4GABAergic synapse_Homo sapiens_hsa047272.75164535
5Circadian entrainment_Homo sapiens_hsa047132.67824222
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64154350
7Long-term potentiation_Homo sapiens_hsa047202.62130089
8Glutamatergic synapse_Homo sapiens_hsa047242.53574903
9Morphine addiction_Homo sapiens_hsa050322.46339236
10Amphetamine addiction_Homo sapiens_hsa050312.45935197
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38761646
12Dopaminergic synapse_Homo sapiens_hsa047282.22301698
13Insulin secretion_Homo sapiens_hsa049112.20801834
14Salivary secretion_Homo sapiens_hsa049702.11586572
15Cholinergic synapse_Homo sapiens_hsa047251.96631609
16Taste transduction_Homo sapiens_hsa047421.94132350
17Gastric acid secretion_Homo sapiens_hsa049711.86476604
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83324117
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80458206
20Cocaine addiction_Homo sapiens_hsa050301.73783643
21Vitamin B6 metabolism_Homo sapiens_hsa007501.72769641
22Serotonergic synapse_Homo sapiens_hsa047261.68914013
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67500174
24Long-term depression_Homo sapiens_hsa047301.67404961
25Renin secretion_Homo sapiens_hsa049241.66947589
26Oxytocin signaling pathway_Homo sapiens_hsa049211.58789648
27Collecting duct acid secretion_Homo sapiens_hsa049661.54060260
28Calcium signaling pathway_Homo sapiens_hsa040201.52090328
29GnRH signaling pathway_Homo sapiens_hsa049121.48124888
30Gap junction_Homo sapiens_hsa045401.37259016
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35348551
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33129864
33Type II diabetes mellitus_Homo sapiens_hsa049301.30576167
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23361822
35Estrogen signaling pathway_Homo sapiens_hsa049151.22367415
36cAMP signaling pathway_Homo sapiens_hsa040241.22134284
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15752291
38Cardiac muscle contraction_Homo sapiens_hsa042601.14691074
39Vibrio cholerae infection_Homo sapiens_hsa051101.08523624
40Glioma_Homo sapiens_hsa052141.06598461
41Phototransduction_Homo sapiens_hsa047441.04315710
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02580900
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01455139
44Melanogenesis_Homo sapiens_hsa049161.00810315
45Axon guidance_Homo sapiens_hsa043601.00734851
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94678703
47ErbB signaling pathway_Homo sapiens_hsa040120.93781749
48Pancreatic secretion_Homo sapiens_hsa049720.93073676
49Oocyte meiosis_Homo sapiens_hsa041140.92234524
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.90552341
51Dorso-ventral axis formation_Homo sapiens_hsa043200.89375544
52Thyroid hormone synthesis_Homo sapiens_hsa049180.86664070
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.80276195
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78856661
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78354690
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75410428
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68099403
58Glucagon signaling pathway_Homo sapiens_hsa049220.65561978
59Choline metabolism in cancer_Homo sapiens_hsa052310.65296010
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.64963911
61Dilated cardiomyopathy_Homo sapiens_hsa054140.64823389
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64032726
63Type I diabetes mellitus_Homo sapiens_hsa049400.63283925
64Alcoholism_Homo sapiens_hsa050340.62476458
65Nitrogen metabolism_Homo sapiens_hsa009100.61820694
66* MAPK signaling pathway_Homo sapiens_hsa040100.61593691
67Alzheimers disease_Homo sapiens_hsa050100.58251034
68VEGF signaling pathway_Homo sapiens_hsa043700.57999590
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52256147
70mTOR signaling pathway_Homo sapiens_hsa041500.51506449
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51374323
72Bile secretion_Homo sapiens_hsa049760.50833336
73Ras signaling pathway_Homo sapiens_hsa040140.50509359
74Inositol phosphate metabolism_Homo sapiens_hsa005620.50418266
75Arginine and proline metabolism_Homo sapiens_hsa003300.49223757
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48372725
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.46490785
78Circadian rhythm_Homo sapiens_hsa047100.46451355
79Endocytosis_Homo sapiens_hsa041440.45971857
80Rap1 signaling pathway_Homo sapiens_hsa040150.45944438
81Insulin signaling pathway_Homo sapiens_hsa049100.45613592
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45581664
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44696373
84Prion diseases_Homo sapiens_hsa050200.44640548
85Endometrial cancer_Homo sapiens_hsa052130.44529172
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41010614
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40775877
88Oxidative phosphorylation_Homo sapiens_hsa001900.39092994
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38500205
90Fatty acid biosynthesis_Homo sapiens_hsa000610.38328465
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38207410
92Renal cell carcinoma_Homo sapiens_hsa052110.36338324
93Wnt signaling pathway_Homo sapiens_hsa043100.35960827
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35863648
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35590002
96Non-small cell lung cancer_Homo sapiens_hsa052230.34885502
97Histidine metabolism_Homo sapiens_hsa003400.34618188
98Ovarian steroidogenesis_Homo sapiens_hsa049130.33953998
99Parkinsons disease_Homo sapiens_hsa050120.33533675
100Arginine biosynthesis_Homo sapiens_hsa002200.33287759
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31948677
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31602527
103Mineral absorption_Homo sapiens_hsa049780.31296197
104beta-Alanine metabolism_Homo sapiens_hsa004100.29427013
105AMPK signaling pathway_Homo sapiens_hsa041520.26317603
106Chemokine signaling pathway_Homo sapiens_hsa040620.25913388
107Prolactin signaling pathway_Homo sapiens_hsa049170.25804734
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.25509818
109African trypanosomiasis_Homo sapiens_hsa051430.24515306
110Hippo signaling pathway_Homo sapiens_hsa043900.24400973
111Tight junction_Homo sapiens_hsa045300.19879829
112Regulation of autophagy_Homo sapiens_hsa041400.19274926
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18775812

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »