MAPK8IP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.41953827
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.08188659
3locomotory exploration behavior (GO:0035641)5.97617310
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.54182592
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28153859
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.94548042
7vocalization behavior (GO:0071625)4.92236241
8glutamate secretion (GO:0014047)4.90465287
9synaptic vesicle exocytosis (GO:0016079)4.90144006
10regulation of synaptic vesicle exocytosis (GO:2000300)4.83939898
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76735200
12regulation of glutamate receptor signaling pathway (GO:1900449)4.58552093
13exploration behavior (GO:0035640)4.40134026
14neurotransmitter secretion (GO:0007269)4.37870321
15activation of protein kinase A activity (GO:0034199)4.34114812
16regulation of synapse structural plasticity (GO:0051823)4.33258363
17regulation of synaptic vesicle transport (GO:1902803)4.32843136
18sodium ion export (GO:0071436)4.30437615
19regulation of neuronal synaptic plasticity (GO:0048168)4.29780626
20layer formation in cerebral cortex (GO:0021819)4.29114620
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.21819338
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13259771
23cellular potassium ion homeostasis (GO:0030007)4.12950893
24protein localization to synapse (GO:0035418)4.09283628
25neuronal action potential propagation (GO:0019227)4.07180862
26proline transport (GO:0015824)4.05867122
27cerebellar granule cell differentiation (GO:0021707)4.01282836
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.99310361
29gamma-aminobutyric acid transport (GO:0015812)3.99043312
30negative regulation of erythrocyte differentiation (GO:0045647)3.89279807
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86722621
32regulation of ARF GTPase activity (GO:0032312)3.83599601
33cell communication by electrical coupling (GO:0010644)3.78795101
34dendritic spine morphogenesis (GO:0060997)3.75987816
35synaptic transmission, glutamatergic (GO:0035249)3.74195723
36glycine transport (GO:0015816)3.72908500
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68781623
38long-term memory (GO:0007616)3.68438256
39neuromuscular process controlling balance (GO:0050885)3.65012057
40cerebellar Purkinje cell differentiation (GO:0021702)3.60672709
41neurotransmitter-gated ion channel clustering (GO:0072578)3.58444693
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.58351179
43neuron cell-cell adhesion (GO:0007158)3.55866387
44glutamate receptor signaling pathway (GO:0007215)3.54325900
45mannose metabolic process (GO:0006013)3.53175926
46positive regulation of Rap GTPase activity (GO:0032854)3.52231287
47regulation of ARF protein signal transduction (GO:0032012)3.47741203
48neuromuscular process controlling posture (GO:0050884)3.47029061
49neurotransmitter transport (GO:0006836)3.43868291
50neuron-neuron synaptic transmission (GO:0007270)3.41774329
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40798751
52positive regulation of membrane potential (GO:0045838)3.39202868
53regulation of synapse maturation (GO:0090128)3.35608897
54vesicle transport along microtubule (GO:0047496)3.32536115
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32162809
56synaptic vesicle endocytosis (GO:0048488)3.30432569
57amino acid import (GO:0043090)3.29885408
58regulation of synaptic plasticity (GO:0048167)3.29496895
59membrane depolarization during action potential (GO:0086010)3.27465268
60potassium ion import (GO:0010107)3.27057622
61dendrite morphogenesis (GO:0048813)3.26838894
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.23974899
63regulation of postsynaptic membrane potential (GO:0060078)3.23344298
64positive regulation of synapse maturation (GO:0090129)3.22160975
65regulation of neurotransmitter secretion (GO:0046928)3.21942900
66regulation of neurotransmitter levels (GO:0001505)3.21039054
67regulation of dendritic spine morphogenesis (GO:0061001)3.19584564
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16573307
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16498498
70auditory behavior (GO:0031223)3.16176519
71response to auditory stimulus (GO:0010996)3.15665307
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15071746
73peptidyl-tyrosine autophosphorylation (GO:0038083)3.14536935
74prepulse inhibition (GO:0060134)3.13753748
75transmission of nerve impulse (GO:0019226)3.12777395
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08510681
77positive regulation of neurotransmitter transport (GO:0051590)3.07170556
78regulation of Rap GTPase activity (GO:0032317)3.06218837
79neuronal ion channel clustering (GO:0045161)3.04756410
80positive regulation of neurotransmitter secretion (GO:0001956)3.03285611
81signal complex assembly (GO:0007172)3.01258521
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01236178
83regulation of neurotransmitter transport (GO:0051588)2.98903605
84L-amino acid import (GO:0043092)2.97125014
85membrane depolarization (GO:0051899)2.96278451
86long-term synaptic potentiation (GO:0060291)2.95304992
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.95209989
88cerebellar Purkinje cell layer development (GO:0021680)2.92609976
89neuron recognition (GO:0008038)2.91965416
90cellular sodium ion homeostasis (GO:0006883)2.91308522
91potassium ion homeostasis (GO:0055075)2.91278288
92regulation of vesicle fusion (GO:0031338)2.90071617
93neuromuscular process (GO:0050905)2.89945056
94membrane hyperpolarization (GO:0060081)2.88342620
95establishment of nucleus localization (GO:0040023)2.87566175
96organelle transport along microtubule (GO:0072384)2.87037910
97regulation of clathrin-mediated endocytosis (GO:2000369)2.86211515
98cell communication involved in cardiac conduction (GO:0086065)2.84491636
99innervation (GO:0060384)2.84312415
100cell migration in hindbrain (GO:0021535)2.83921046
101positive regulation of potassium ion transmembrane transport (GO:1901381)2.82387462
102cytoskeletal anchoring at plasma membrane (GO:0007016)2.80185000
103alanine transport (GO:0032328)2.80099811
104positive regulation of synaptic transmission (GO:0050806)2.79218989
105axon cargo transport (GO:0008088)2.78967130
106axonal fasciculation (GO:0007413)2.78557651
107chemosensory behavior (GO:0007635)2.75496006
108positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.75409122
109regulation of synaptic transmission (GO:0050804)2.74523749
110regulation of voltage-gated calcium channel activity (GO:1901385)2.73985763
111learning (GO:0007612)2.73700233
112axon ensheathment in central nervous system (GO:0032291)2.68293245
113central nervous system myelination (GO:0022010)2.68293245
114semaphorin-plexin signaling pathway (GO:0071526)2.64720266
115positive regulation of CREB transcription factor activity (GO:0032793)2.63482028
116positive thymic T cell selection (GO:0045059)2.52826183
117cell-cell junction maintenance (GO:0045217)2.47320969
118thymic T cell selection (GO:0045061)2.46061290
119positive regulation of protein dephosphorylation (GO:0035307)2.45170178
120regulation of T-helper 2 cell differentiation (GO:0045628)2.42864746
121response to muramyl dipeptide (GO:0032495)2.41315121
122activation of MAPKKK activity (GO:0000185)2.39472638
123cell differentiation in hindbrain (GO:0021533)2.38251320
124histone H4 deacetylation (GO:0070933)2.38142143
125negative regulation of cell killing (GO:0031342)2.36512264
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.36512264
127positive regulation of dendritic spine development (GO:0060999)2.35598231
128activation of Rac GTPase activity (GO:0032863)2.34279168
129protein targeting to plasma membrane (GO:0072661)2.31596046
130dendritic spine organization (GO:0097061)2.31049598
131negative regulation of dendrite morphogenesis (GO:0050774)2.28658866
132cell volume homeostasis (GO:0006884)2.26306492
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.23073779
134histone H3 deacetylation (GO:0070932)2.22178359
135dopamine receptor signaling pathway (GO:0007212)2.21623481
136adherens junction assembly (GO:0034333)2.20595965
137histone H3-K9 demethylation (GO:0033169)2.19713155
138negative regulation of Ras protein signal transduction (GO:0046580)2.19467032
139positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.19037118
140myelin maintenance (GO:0043217)2.18470852
141positive regulation of dendrite development (GO:1900006)2.17994655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47206625
2DROSHA_22980978_ChIP-Seq_HELA_Human2.97202833
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.94360336
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85631024
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85043443
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74902714
7GBX2_23144817_ChIP-Seq_PC3_Human2.67646025
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63856157
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63856157
10REST_21632747_ChIP-Seq_MESCs_Mouse2.63512155
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57395613
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47266458
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47060528
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46891602
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.45841319
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.41868901
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32275705
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30576471
19TCF7_22412390_ChIP-Seq_EML_Mouse2.30037608
20VDR_21846776_ChIP-Seq_THP-1_Human2.28840778
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27255504
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24798696
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.22731699
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.18410660
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17625518
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.13607635
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.08513498
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04407877
29MYC_22102868_ChIP-Seq_BL_Human2.01095539
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.91099024
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89499272
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.86988216
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80054849
34* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75697604
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72966867
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70520276
37* P68_20966046_ChIP-Seq_HELA_Human1.69325336
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.67830490
39* RACK7_27058665_Chip-Seq_MCF-7_Human1.64454203
40KDM2B_26808549_Chip-Seq_K562_Human1.62994804
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58421467
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57014728
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55647979
44AR_21572438_ChIP-Seq_LNCaP_Human1.53689503
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52803794
46* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51733320
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50536383
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49794444
49CREB1_26743006_Chip-Seq_LNCaP_Human1.48985258
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48947153
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.47374232
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47292353
53VDR_24763502_ChIP-Seq_THP-1_Human1.43129196
54ZNF274_21170338_ChIP-Seq_K562_Hela1.40260146
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39531858
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38899910
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36994814
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36774279
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35322525
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.33447843
61SMAD4_21799915_ChIP-Seq_A2780_Human1.33166097
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.33087598
63* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29901930
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.29468060
65AR_19668381_ChIP-Seq_PC3_Human1.27368382
66MAF_26560356_Chip-Seq_TH1_Human1.26200345
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26108097
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25653065
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25329037
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24852253
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24117876
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24103487
73MAF_26560356_Chip-Seq_TH2_Human1.23925027
74* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22410277
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.21360658
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17475441
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.16873341
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.15446377
79UTX_26944678_Chip-Seq_JUKART_Human1.15318063
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15045705
81* OCT4_19829295_ChIP-Seq_ESCs_Human1.15042529
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14315927
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13365928
84* BCOR_27268052_Chip-Seq_Bcells_Human1.12618983
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12381235
86* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11441181
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11309177
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11225936
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.10864056
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10801927
91* ELF1_20517297_ChIP-Seq_JURKAT_Human1.10623249
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09509166
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09322138
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09209059
95KDM2B_26808549_Chip-Seq_DND41_Human1.08285439
96* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08093610
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06941091
98* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06849870
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06481883
100GATA1_19941826_ChIP-Seq_K562_Human1.05776613
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.05632606
102SCL_19346495_ChIP-Seq_HPC-7_Human1.04763123
103STAT3_23295773_ChIP-Seq_U87_Human1.04448252
104SPI1_23127762_ChIP-Seq_K562_Human1.04095567
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03464071
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03391372
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.03345868
108TP63_22573176_ChIP-Seq_HFKS_Human1.03335684
109BCL6_27268052_Chip-Seq_Bcells_Human1.01798360
110CTCF_27219007_Chip-Seq_Bcells_Human1.00421773
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00184367
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00093835
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.99526841
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99341094
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97297905
116AHR_22903824_ChIP-Seq_MCF-7_Human0.96923353
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.96863991
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96860838
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96596794
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96038696
121AR_25329375_ChIP-Seq_VCAP_Human0.95296394
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.94262201
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.93953303
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92247758
125CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91995466
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91818109
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.91393643
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.91222370
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91055987
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.90945844
131LXR_22292898_ChIP-Seq_THP-1_Human0.90846336
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90362081
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89363932
134TCF4_23295773_ChIP-Seq_U87_Human0.89311564
135RXR_22108803_ChIP-Seq_LS180_Human0.89122084
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.88750894
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87349166
138* SMC4_20622854_ChIP-Seq_HELA_Human0.87219571
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85734924
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85637571
141* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84955850
142TAF15_26573619_Chip-Seq_HEK293_Human0.82690886
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.82559697
144* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82369728
145* KLF4_19829295_ChIP-Seq_ESCs_Human0.82193042
146EP300_21415370_ChIP-Seq_HL-1_Mouse0.80795866
147STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77851780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.95441357
2* MP0003635_abnormal_synaptic_transmissio4.12443134
3MP0003880_abnormal_central_pattern4.04134344
4MP0004270_analgesia3.74210987
5MP0009745_abnormal_behavioral_response3.30779445
6MP0002063_abnormal_learning/memory/cond3.18173210
7MP0009046_muscle_twitch3.10945739
8MP0002064_seizures3.07595162
9MP0005423_abnormal_somatic_nervous2.86443453
10MP0001968_abnormal_touch/_nociception2.84341809
11MP0002822_catalepsy2.78480011
12MP0002734_abnormal_mechanical_nocicepti2.59296022
13MP0002572_abnormal_emotion/affect_behav2.56982888
14MP0002272_abnormal_nervous_system2.48834732
15MP0001486_abnormal_startle_reflex2.44089885
16MP0005409_darkened_coat_color2.27163516
17MP0004858_abnormal_nervous_system2.25068936
18MP0003705_abnormal_hypodermis_morpholog2.24964572
19MP0009780_abnormal_chondrocyte_physiolo2.23854726
20MP0002735_abnormal_chemical_nociception2.23701589
21MP0008569_lethality_at_weaning2.17497733
22MP0002909_abnormal_adrenal_gland2.16252792
23MP0001501_abnormal_sleep_pattern2.09046829
24MP0002736_abnormal_nociception_after2.05432526
25MP0002733_abnormal_thermal_nociception2.05274706
26MP0003329_amyloid_beta_deposits1.98547145
27MP0001970_abnormal_pain_threshold1.95444077
28MP0008260_abnormal_autophagy1.92968788
29* MP0004811_abnormal_neuron_physiology1.90073635
30MP0000569_abnormal_digit_pigmentation1.88673949
31MP0001440_abnormal_grooming_behavior1.88673911
32MP0002067_abnormal_sensory_capabilities1.84708737
33MP0003787_abnormal_imprinting1.77373517
34MP0003303_peritoneal_inflammation1.76520153
35MP0003436_decreased_susceptibility_to1.76302314
36MP0005058_abnormal_lysosome_morphology1.70820778
37MP0002184_abnormal_innervation1.67352199
38MP0000955_abnormal_spinal_cord1.63855320
39MP0004885_abnormal_endolymph1.63195123
40MP0004924_abnormal_behavior1.63105282
41MP0005386_behavior/neurological_phenoty1.63105282
42MP0002557_abnormal_social/conspecific_i1.57707775
43MP0009278_abnormal_bone_marrow1.56570463
44MP0003633_abnormal_nervous_system1.52196945
45* MP0000778_abnormal_nervous_system1.51623326
46MP0001849_ear_inflammation1.46094560
47MP0005076_abnormal_cell_differentiation1.45977927
48MP0002249_abnormal_larynx_morphology1.45959738
49MP0000751_myopathy1.45412383
50MP0003283_abnormal_digestive_organ1.40132175
51MP0003879_abnormal_hair_cell1.39899374
52MP0008961_abnormal_basal_metabolism1.39311658
53MP0002066_abnormal_motor_capabilities/c1.39061002
54MP0005646_abnormal_pituitary_gland1.38115205
55* MP0002882_abnormal_neuron_morphology1.37344682
56MP0004510_myositis1.35321143
57MP0003279_aneurysm1.34244388
58MP0001984_abnormal_olfaction1.30846237
59MP0003631_nervous_system_phenotype1.24687364
60MP0003091_abnormal_cell_migration1.21794987
61MP0006276_abnormal_autonomic_nervous1.21362599
62MP0001958_emphysema1.20159587
63MP0003123_paternal_imprinting1.17173907
64MP0004145_abnormal_muscle_electrophysio1.17080649
65MP0003122_maternal_imprinting1.17061195
66MP0005645_abnormal_hypothalamus_physiol1.14460016
67MP0001502_abnormal_circadian_rhythm1.12922894
68MP0001348_abnormal_lacrimal_gland1.09489900
69MP0003075_altered_response_to1.08837093
70MP0004947_skin_inflammation1.05665302
71MP0001986_abnormal_taste_sensitivity1.05206302
72* MP0002152_abnormal_brain_morphology1.05104344
73MP0003690_abnormal_glial_cell1.04635665
74MP0004142_abnormal_muscle_tone1.04301559
75MP0005167_abnormal_blood-brain_barrier1.02941288
76MP0008872_abnormal_physiological_respon1.01875115
77MP0002229_neurodegeneration1.00436519
78MP0003172_abnormal_lysosome_physiology0.98928513
79MP0000013_abnormal_adipose_tissue0.98142283
80MP0003300_gastrointestinal_ulcer0.97875700
81MP0003183_abnormal_peptide_metabolism0.97541523
82MP0002933_joint_inflammation0.96872295
83MP0008874_decreased_physiological_sensi0.95530360
84MP0004085_abnormal_heartbeat0.95225351
85MP0000920_abnormal_myelination0.95109105
86MP0003763_abnormal_thymus_physiology0.94167251
87* MP0003634_abnormal_glial_cell0.93508047
88MP0004381_abnormal_hair_follicle0.92848314
89MP0002069_abnormal_eating/drinking_beha0.92439595
90MP0000604_amyloidosis0.91899356
91MP0003632_abnormal_nervous_system0.90998433
92MP0000678_abnormal_parathyroid_gland0.88716699
93MP0002837_dystrophic_cardiac_calcinosis0.87536165
94MP0005535_abnormal_body_temperature0.87027205
95MP0005623_abnormal_meninges_morphology0.87004114
96MP0004130_abnormal_muscle_cell0.85724294
97MP0004215_abnormal_myocardial_fiber0.85420561
98MP0002998_abnormal_bone_remodeling0.83495255
99MP0000003_abnormal_adipose_tissue0.83302359
100MP0004233_abnormal_muscle_weight0.81179569
101MP0000747_muscle_weakness0.80819582
102MP0003137_abnormal_impulse_conducting0.79460928
103MP0005666_abnormal_adipose_tissue0.79442171
104MP0005375_adipose_tissue_phenotype0.78411225
105MP0003646_muscle_fatigue0.78249368
106MP0005166_decreased_susceptibility_to0.78027957
107MP0001299_abnormal_eye_distance/0.75078091
108MP0001905_abnormal_dopamine_level0.74858423
109MP0003191_abnormal_cellular_cholesterol0.73813306
110* MP0001177_atelectasis0.69271202
111MP0004484_altered_response_of0.69020483
112MP0005000_abnormal_immune_tolerance0.68541866
113MP0000681_abnormal_thyroid_gland0.67653556
114MP0002419_abnormal_innate_immunity0.67222675
115MP0003045_fibrosis0.66459291
116MP0005670_abnormal_white_adipose0.65466607
117MP0001851_eye_inflammation0.65426513
118MP0005551_abnormal_eye_electrophysiolog0.64335783
119MP0003453_abnormal_keratinocyte_physiol0.63161660
120MP0002090_abnormal_vision0.61938712
121MP0004742_abnormal_vestibular_system0.61550827
122MP0006138_congestive_heart_failure0.60591915
123MP0001765_abnormal_ion_homeostasis0.60525186
124MP0001800_abnormal_humoral_immune0.60378489
125MP0005394_taste/olfaction_phenotype0.60162181
126MP0005499_abnormal_olfactory_system0.60162181
127MP0002089_abnormal_postnatal_growth/wei0.59873661
128MP0010234_abnormal_vibrissa_follicle0.59849913
129MP0001533_abnormal_skeleton_physiology0.59620659
130MP0004036_abnormal_muscle_relaxation0.59181667
131MP0005025_abnormal_response_to0.58850974
132MP0005387_immune_system_phenotype0.58689137
133MP0001790_abnormal_immune_system0.58689137
134MP0000733_abnormal_muscle_development0.58498138
135MP0002396_abnormal_hematopoietic_system0.57182192
136* MP0010769_abnormal_survival0.56779930
137* MP0002752_abnormal_somatic_nervous0.56417899
138MP0001963_abnormal_hearing_physiology0.54985998
139MP0001529_abnormal_vocalization0.54855769
140MP0005620_abnormal_muscle_contractility0.53047888
141* MP0010768_mortality/aging0.52868833
142* MP0002082_postnatal_lethality0.52626945
143* MP0010770_preweaning_lethality0.52626945

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.63344873
2Focal motor seizures (HP:0011153)6.03832969
3Obstructive sleep apnea (HP:0002870)5.55455263
4Focal seizures (HP:0007359)5.11699458
5Visual hallucinations (HP:0002367)5.10016422
6Action tremor (HP:0002345)4.31380828
7Supranuclear gaze palsy (HP:0000605)3.95452679
8Progressive cerebellar ataxia (HP:0002073)3.83867270
9Postural instability (HP:0002172)3.81838533
10Febrile seizures (HP:0002373)3.72350753
11Ankle clonus (HP:0011448)3.72232234
12Epileptic encephalopathy (HP:0200134)3.61225176
13Atonic seizures (HP:0010819)3.57295097
14Depression (HP:0000716)3.40888304
15Absence seizures (HP:0002121)3.34083911
16Impaired vibration sensation in the lower limbs (HP:0002166)3.24656634
17Generalized tonic-clonic seizures (HP:0002069)3.24487479
18Poor eye contact (HP:0000817)3.22748931
19Urinary bladder sphincter dysfunction (HP:0002839)3.20587410
20Scanning speech (HP:0002168)3.18861713
21Cerebral aneurysm (HP:0004944)3.14671312
22Gaze-evoked nystagmus (HP:0000640)3.13632121
23Abnormal social behavior (HP:0012433)3.06227277
24Impaired social interactions (HP:0000735)3.06227277
25Abnormality of the lower motor neuron (HP:0002366)3.04504992
26Dialeptic seizures (HP:0011146)3.03183212
27Truncal ataxia (HP:0002078)3.02458643
28Papilledema (HP:0001085)3.00927475
29Broad face (HP:0000283)2.99904959
30Ventricular fibrillation (HP:0001663)2.97154430
31Bundle branch block (HP:0011710)2.90604578
32Dysdiadochokinesis (HP:0002075)2.89947339
33Dysmetria (HP:0001310)2.89918339
34Hemiplegia (HP:0002301)2.89286516
35Insomnia (HP:0100785)2.88598333
36Urinary urgency (HP:0000012)2.87522670
37Genetic anticipation (HP:0003743)2.87282144
38Mutism (HP:0002300)2.84431232
39Dysmetric saccades (HP:0000641)2.79093413
40Anxiety (HP:0000739)2.77060459
41Broad-based gait (HP:0002136)2.72790273
42Torticollis (HP:0000473)2.66694842
43Impaired smooth pursuit (HP:0007772)2.64688145
44Abnormal eating behavior (HP:0100738)2.61756849
45Spastic gait (HP:0002064)2.60828219
46Termporal pattern (HP:0011008)2.56833838
47Insidious onset (HP:0003587)2.56833838
48Pointed chin (HP:0000307)2.53868166
49Upper limb amyotrophy (HP:0009129)2.50912513
50Distal upper limb amyotrophy (HP:0007149)2.50912513
51Bradykinesia (HP:0002067)2.47261296
52Intention tremor (HP:0002080)2.47081234
53Abnormality of the fingertips (HP:0001211)2.45153406
54Lower limb muscle weakness (HP:0007340)2.44774501
55Annular pancreas (HP:0001734)2.43371743
56Thin bony cortex (HP:0002753)2.38510165
57Megalencephaly (HP:0001355)2.38259267
58Focal dystonia (HP:0004373)2.38257688
59Abnormality of binocular vision (HP:0011514)2.36413737
60Diplopia (HP:0000651)2.36413737
61Abnormality of ocular smooth pursuit (HP:0000617)2.35327573
62Turricephaly (HP:0000262)2.33796969
63Shallow orbits (HP:0000586)2.31879997
64Hemiparesis (HP:0001269)2.31220388
65Sleep apnea (HP:0010535)2.29378469
66Abnormal EKG (HP:0003115)2.28859000
67Stereotypic behavior (HP:0000733)2.28341814
68Resting tremor (HP:0002322)2.26737328
69Hyperacusis (HP:0010780)2.26705214
70Drooling (HP:0002307)2.25393453
71Excessive salivation (HP:0003781)2.25393453
72Peripheral hypomyelination (HP:0007182)2.23108766
73Slow saccadic eye movements (HP:0000514)2.23084939
74Cerebral inclusion bodies (HP:0100314)2.22556523
75Bronchomalacia (HP:0002780)2.21529307
76Amblyopia (HP:0000646)2.19842643
77Progressive inability to walk (HP:0002505)2.19107680
78Impaired vibratory sensation (HP:0002495)2.18775104
79Prolonged QT interval (HP:0001657)2.18450434
80Neurofibrillary tangles (HP:0002185)2.18284616
81Stridor (HP:0010307)2.16026757
82Lower limb amyotrophy (HP:0007210)2.14941744
83Abnormality of saccadic eye movements (HP:0000570)2.13326784
84Craniofacial dystonia (HP:0012179)2.12190527
85Abnormality of the corticospinal tract (HP:0002492)2.11189485
86Rapidly progressive (HP:0003678)2.09637007
87Lower limb asymmetry (HP:0100559)2.08240860
88Neuronal loss in central nervous system (HP:0002529)2.06037847
89Clonus (HP:0002169)2.05772425
90Macroorchidism (HP:0000053)2.05743750
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04892093
92Dysostosis multiplex (HP:0000943)2.04728202
93Pheochromocytoma (HP:0002666)2.03373659
94Postural tremor (HP:0002174)2.03195701
95Akinesia (HP:0002304)2.02961085
96Agitation (HP:0000713)2.02904428
97Onion bulb formation (HP:0003383)2.02828794
98J-shaped sella turcica (HP:0002680)2.01917118
99Neoplasm of the heart (HP:0100544)1.98416265
100Hand muscle atrophy (HP:0009130)1.98171188
101Status epilepticus (HP:0002133)1.96438513
102Distal lower limb amyotrophy (HP:0008944)1.95676634
103Cellulitis (HP:0100658)1.94641775
104Eczematoid dermatitis (HP:0000976)1.94542387
105Elfin facies (HP:0004428)1.93941589
106Mucopolysacchariduria (HP:0008155)1.89077334
107Urinary glycosaminoglycan excretion (HP:0003541)1.89077334
108Colitis (HP:0002583)1.88353649
109Rigidity (HP:0002063)1.87101237
110Hypercortisolism (HP:0001578)1.86897584
111Ocular albinism (HP:0001107)1.85073298
112Incomplete penetrance (HP:0003829)1.84660421
113Epileptiform EEG discharges (HP:0011182)1.84063978
114Diminished motivation (HP:0000745)1.83826684
115EEG with generalized epileptiform discharges (HP:0011198)1.83789558
116Heart block (HP:0012722)1.83756765
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82834639
118Mitral regurgitation (HP:0001653)1.81550082
119Gait ataxia (HP:0002066)1.80827063
120Hypsarrhythmia (HP:0002521)1.80565934
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79283475
122Abnormality of polysaccharide metabolism (HP:0011012)1.79283475
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79283475
124Apathy (HP:0000741)1.78901655
125Inappropriate behavior (HP:0000719)1.78808564
126Limb dystonia (HP:0002451)1.77125394
127Nuclear cataract (HP:0100018)1.76642750
128Cervical subluxation (HP:0003308)1.76625047
129Amyotrophic lateral sclerosis (HP:0007354)1.76131418
130Spinal canal stenosis (HP:0003416)1.75442038
131Mask-like facies (HP:0000298)1.74661024
132Syncope (HP:0001279)1.73546557
133Tetraplegia (HP:0002445)1.71678626
134Hypoventilation (HP:0002791)1.71452814
135Atrioventricular block (HP:0001678)1.70016861
136Lymphangioma (HP:0100764)1.69148919
137Broad metatarsal (HP:0001783)1.68003547
138Abnormality of the periventricular white matter (HP:0002518)1.67364576
139Long palpebral fissure (HP:0000637)1.66658064
140Mild short stature (HP:0003502)1.66102472
141Emphysema (HP:0002097)1.65019972
142Increased IgE level (HP:0003212)1.64198545
143Hemorrhage of the eye (HP:0011885)1.63992993
144Ulnar bowing (HP:0003031)1.63830795
145Metaphyseal cupping (HP:0003021)1.63118286
146Aneurysm (HP:0002617)1.63028418
147Bowel incontinence (HP:0002607)1.62755457
148Thin ribs (HP:0000883)1.62656897
149Polygenic inheritance (HP:0010982)1.59575834
150Segmental peripheral demyelination/remyelination (HP:0003481)1.59232890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.14212341
2MAP3K93.95064186
3EPHA43.53991532
4MARK12.82757071
5PRKD32.68157579
6MINK12.63378677
7DAPK22.56604882
8MAP3K42.56447739
9PAK62.51709271
10KSR22.29015978
11CAMKK12.21285425
12NTRK22.15511384
13NTRK12.10073248
14SIK12.02905876
15MAP2K71.82678306
16ERN11.79855329
17STK381.73851047
18MAP3K121.64610571
19CDK51.62684763
20MAP2K41.58682439
21EEF2K1.56895830
22RIPK41.55348425
23SIK21.54982466
24MAP4K11.50663024
25LMTK21.49466780
26MAP3K131.44339952
27PRKCH1.42634172
28TYRO31.37140821
29CDK121.37105039
30DAPK11.36995340
31TAOK11.36013561
32PHKG11.35117706
33PHKG21.35117706
34FGFR41.31672618
35KSR11.29331509
36UHMK11.24986904
37MAP3K21.22428719
38MAPK121.19716269
39FES1.16724740
40ALK1.16722720
41PINK11.15611283
42PRPF4B1.12920330
43SGK31.12373802
44RIPK11.11166521
45SGK4941.10298091
46SGK2231.10298091
47RET1.08698856
48SMG11.08527606
49PRKCG1.06470029
50MAP2K31.06355745
51GRK51.02726143
52CAMK1G1.01773614
53CDK191.01736769
54CAMKK21.01712990
55STK111.01274815
56CAMK11.00564770
57TNIK1.00181590
58LATS20.99168227
59MAP3K110.98745533
60SGK20.96734507
61WNK10.96156498
62MAPK130.95194874
63TRIB30.93793505
64MAPK150.92705118
65BLK0.86887396
66SIK30.86822557
67ZAP700.86358543
68PLK20.86157930
69MARK20.85883453
70CDC42BPA0.85103122
71MAP3K70.81751892
72MAP3K60.81468888
73PAK30.80070071
74PDK10.79722830
75CDK150.78361218
76MAP3K100.77397277
77CDK180.76883423
78CAMK2A0.73384250
79ARAF0.72749787
80SGK10.72435165
81JAK10.72309838
82MAP2K60.71870843
83PDPK10.71738477
84DMPK0.71472610
85SCYL20.71124043
86CDK140.71033065
87MAP3K10.70696336
88PNCK0.70010004
89TYK20.69853132
90BMX0.69765753
91FGFR30.68695408
92CDK11A0.67497589
93CAMK40.67013550
94RPS6KA20.66346023
95EPHB10.66007483
96TNK20.65634356
97MTOR0.65548514
98MAPK70.64514305
99PTK60.62752134
100DDR20.61571728
101RPS6KL10.60923423
102RPS6KC10.60923423
103RPS6KA30.59673125
104DYRK1B0.58695842
105RAF10.57636835
106PTK2B0.57047003
107TTN0.56734056
108ICK0.56539441
109PDGFRA0.55623696
110NEK10.55006186
111GRK60.54698962
112ERBB20.54454172
113FYN0.54366137
114PRKD20.53715501
115HCK0.52361859
116CSNK1G20.51169166
117IRAK20.50945547
118DAPK30.50367217
119TBK10.50348496
120SYK0.49899509
121CAMK2B0.49843572
122PRKCZ0.49568537
123JAK30.49173161
124* MAPK100.49133993
125JAK20.48326293
126DYRK1A0.48188612
127PKN20.47072618
128MAP3K30.46237662
129BTK0.45637103
130RPS6KA60.45215734
131NEK60.42189241
132PRKD10.40167457
133CAMK2D0.38666471
134CAMK1D0.38193085
135ROCK20.34778841
136PRKCE0.34619268
137* MAPK80.34237544
138FER0.34164680
139FGFR20.32875999
140PRKCB0.32804194
141HIPK20.31768935

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.02182588
2Nicotine addiction_Homo sapiens_hsa050332.82562483
3Olfactory transduction_Homo sapiens_hsa047402.67538462
4Circadian entrainment_Homo sapiens_hsa047132.55050713
5GABAergic synapse_Homo sapiens_hsa047272.42179954
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39275300
7Long-term potentiation_Homo sapiens_hsa047202.36647330
8Glutamatergic synapse_Homo sapiens_hsa047242.31843267
9Morphine addiction_Homo sapiens_hsa050322.23133995
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22962602
11Amphetamine addiction_Homo sapiens_hsa050312.07858098
12Salivary secretion_Homo sapiens_hsa049702.02036558
13Insulin secretion_Homo sapiens_hsa049111.99507725
14Dopaminergic synapse_Homo sapiens_hsa047281.96746147
15Gastric acid secretion_Homo sapiens_hsa049711.90000635
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89590309
17Cholinergic synapse_Homo sapiens_hsa047251.85987956
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77721609
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63991861
20Oxytocin signaling pathway_Homo sapiens_hsa049211.58331577
21Type II diabetes mellitus_Homo sapiens_hsa049301.55321509
22Cocaine addiction_Homo sapiens_hsa050301.53102864
23Renin secretion_Homo sapiens_hsa049241.51615266
24Taste transduction_Homo sapiens_hsa047421.48598904
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47749282
26Other glycan degradation_Homo sapiens_hsa005111.47099026
27GnRH signaling pathway_Homo sapiens_hsa049121.46190833
28Long-term depression_Homo sapiens_hsa047301.43236156
29Nitrogen metabolism_Homo sapiens_hsa009101.42659052
30Calcium signaling pathway_Homo sapiens_hsa040201.39676747
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34993044
32B cell receptor signaling pathway_Homo sapiens_hsa046621.31826254
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29414988
34Serotonergic synapse_Homo sapiens_hsa047261.29066637
35cAMP signaling pathway_Homo sapiens_hsa040241.28237815
36Gap junction_Homo sapiens_hsa045401.28085687
37Notch signaling pathway_Homo sapiens_hsa043301.27064306
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26871327
39Estrogen signaling pathway_Homo sapiens_hsa049151.26777001
40Glioma_Homo sapiens_hsa052141.25176503
41Acute myeloid leukemia_Homo sapiens_hsa052211.16797227
42Dorso-ventral axis formation_Homo sapiens_hsa043201.07208085
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06222848
44ErbB signaling pathway_Homo sapiens_hsa040121.05656548
45Chronic myeloid leukemia_Homo sapiens_hsa052201.04841581
46Osteoclast differentiation_Homo sapiens_hsa043801.03376227
47Melanogenesis_Homo sapiens_hsa049160.99490975
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.98928696
49Dilated cardiomyopathy_Homo sapiens_hsa054140.96247629
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95448705
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94745842
52Axon guidance_Homo sapiens_hsa043600.94707058
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90800649
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.90670086
55Pancreatic secretion_Homo sapiens_hsa049720.87613283
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.87129038
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86975430
58T cell receptor signaling pathway_Homo sapiens_hsa046600.85312170
59Thyroid hormone synthesis_Homo sapiens_hsa049180.84602982
60Collecting duct acid secretion_Homo sapiens_hsa049660.84418055
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.84339387
62mTOR signaling pathway_Homo sapiens_hsa041500.81693651
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79853296
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78698527
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78407962
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78298551
67Oocyte meiosis_Homo sapiens_hsa041140.78155165
68Choline metabolism in cancer_Homo sapiens_hsa052310.76007638
69Cardiac muscle contraction_Homo sapiens_hsa042600.75910452
70Insulin signaling pathway_Homo sapiens_hsa049100.75185352
71VEGF signaling pathway_Homo sapiens_hsa043700.73368946
72* MAPK signaling pathway_Homo sapiens_hsa040100.71037629
73Leishmaniasis_Homo sapiens_hsa051400.70030367
74Endocytosis_Homo sapiens_hsa041440.68892215
75Glucagon signaling pathway_Homo sapiens_hsa049220.68829543
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66457054
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65673954
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.65628022
79Pancreatic cancer_Homo sapiens_hsa052120.65562407
80Tuberculosis_Homo sapiens_hsa051520.65348900
81Non-small cell lung cancer_Homo sapiens_hsa052230.64577485
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64266945
83Endometrial cancer_Homo sapiens_hsa052130.64253612
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64199518
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.64063138
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62996046
87Rap1 signaling pathway_Homo sapiens_hsa040150.62906370
88Bile secretion_Homo sapiens_hsa049760.62629471
89AMPK signaling pathway_Homo sapiens_hsa041520.62496067
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.61994930
91Toxoplasmosis_Homo sapiens_hsa051450.60673349
92Focal adhesion_Homo sapiens_hsa045100.60392830
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58920983
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58862795
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57615024
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57087106
97Vibrio cholerae infection_Homo sapiens_hsa051100.56950979
98Inositol phosphate metabolism_Homo sapiens_hsa005620.56908757
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56342023
100Amoebiasis_Homo sapiens_hsa051460.56138297
101HIF-1 signaling pathway_Homo sapiens_hsa040660.55736407
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55464049
103TNF signaling pathway_Homo sapiens_hsa046680.54779957
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54740450
105Ras signaling pathway_Homo sapiens_hsa040140.54527744
106Renal cell carcinoma_Homo sapiens_hsa052110.53571402
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51152624
108Chemokine signaling pathway_Homo sapiens_hsa040620.50719620
109Type I diabetes mellitus_Homo sapiens_hsa049400.48949959
110Phototransduction_Homo sapiens_hsa047440.48308271
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48103147
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47088994
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46851493
114Circadian rhythm_Homo sapiens_hsa047100.45657739
115Prolactin signaling pathway_Homo sapiens_hsa049170.43960975
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.43913567
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43310558
118Alcoholism_Homo sapiens_hsa050340.42771517
119Platelet activation_Homo sapiens_hsa046110.42150480
120Prion diseases_Homo sapiens_hsa050200.40618637
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39420533
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39324864
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.37527887
124Ovarian steroidogenesis_Homo sapiens_hsa049130.35368804
125Wnt signaling pathway_Homo sapiens_hsa043100.34210806
126Colorectal cancer_Homo sapiens_hsa052100.32948088

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