MAPK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of catenin import into nucleus (GO:0035414)8.85694184
2replicative senescence (GO:0090399)8.42220020
3hematopoietic stem cell proliferation (GO:0071425)6.77940590
4detection of calcium ion (GO:0005513)6.44309266
5synaptic vesicle maturation (GO:0016188)6.23524754
6regulation of short-term neuronal synaptic plasticity (GO:0048172)6.00549496
7locomotory exploration behavior (GO:0035641)5.86813158
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45712772
9glutamate secretion (GO:0014047)5.40715354
10synaptic vesicle exocytosis (GO:0016079)5.40110247
11regulation of endothelial cell differentiation (GO:0045601)5.32817117
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30927275
13regulation of synaptic vesicle exocytosis (GO:2000300)5.11004930
14vocalization behavior (GO:0071625)5.08083372
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.97755967
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.77981826
17neurotransmitter secretion (GO:0007269)4.77632604
18regulation of synaptic vesicle transport (GO:1902803)4.55916326
19regulation of somitogenesis (GO:0014807)4.53556982
20regulation of glutamate receptor signaling pathway (GO:1900449)4.51221675
21layer formation in cerebral cortex (GO:0021819)4.43578670
22exploration behavior (GO:0035640)4.39934916
23neuronal action potential propagation (GO:0019227)4.35047513
24gamma-aminobutyric acid transport (GO:0015812)4.33423431
25protein localization to synapse (GO:0035418)4.20378486
26regulation of synapse structural plasticity (GO:0051823)4.19488224
27proline transport (GO:0015824)4.19322473
28regulation of neuronal synaptic plasticity (GO:0048168)4.12731915
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.11731043
30cellular potassium ion homeostasis (GO:0030007)4.11550700
31nuclear pore complex assembly (GO:0051292)4.10224929
32ionotropic glutamate receptor signaling pathway (GO:0035235)4.03931544
33activation of protein kinase A activity (GO:0034199)4.03763523
34nuclear pore organization (GO:0006999)4.01899315
35sodium ion export (GO:0071436)4.01743285
36neuron cell-cell adhesion (GO:0007158)3.96372206
37neurotransmitter transport (GO:0006836)3.80339696
38cAMP biosynthetic process (GO:0006171)3.78000277
39neurotransmitter-gated ion channel clustering (GO:0072578)3.76956329
40negative regulation of microtubule polymerization (GO:0031115)3.73666133
41regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.69992280
42positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.68152500
43synaptic transmission, glutamatergic (GO:0035249)3.67168263
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66198274
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.64725013
46regulation of catenin import into nucleus (GO:0035412)3.64350253
47regulation of cell communication by electrical coupling (GO:0010649)3.64128259
48neuromuscular process controlling posture (GO:0050884)3.61642658
49regulation of neurotransmitter levels (GO:0001505)3.59771893
50neuromuscular process controlling balance (GO:0050885)3.57929443
51cerebellar Purkinje cell differentiation (GO:0021702)3.55259931
52neuronal action potential (GO:0019228)3.55079988
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54160244
54neuron-neuron synaptic transmission (GO:0007270)3.53588952
55glutamate receptor signaling pathway (GO:0007215)3.52920839
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.51937342
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51363890
58dendritic spine morphogenesis (GO:0060997)3.50874415
59long-term memory (GO:0007616)3.50776460
60glycine transport (GO:0015816)3.50439219
61regulation of cell cycle G2/M phase transition (GO:1902749)3.49485067
62positive regulation of membrane potential (GO:0045838)3.47163091
63DNA replication-dependent nucleosome assembly (GO:0006335)3.39714462
64DNA replication-dependent nucleosome organization (GO:0034723)3.39714462
65cell communication by electrical coupling (GO:0010644)3.39122426
66regulation of postsynaptic membrane potential (GO:0060078)3.36298532
67regulation of ARF protein signal transduction (GO:0032012)3.35091689
68DNA unwinding involved in DNA replication (GO:0006268)3.32121977
69synaptic vesicle endocytosis (GO:0048488)3.31536573
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31340325
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.30646426
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30529447
73prepulse inhibition (GO:0060134)3.29848607
74vesicle transport along microtubule (GO:0047496)3.29572309
75positive regulation of synapse maturation (GO:0090129)3.26815644
76regulation of cardiac muscle cell contraction (GO:0086004)3.23967057
77ribosome assembly (GO:0042255)3.23954861
78regulation of neurotransmitter secretion (GO:0046928)3.23573443
79dendrite morphogenesis (GO:0048813)3.23508543
80cAMP metabolic process (GO:0046058)3.22766957
81regulation of synaptic plasticity (GO:0048167)3.22384340
82regulation of dendritic spine morphogenesis (GO:0061001)3.19212620
83interkinetic nuclear migration (GO:0022027)3.15188271
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14850817
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12690349
86regulation of DNA damage checkpoint (GO:2000001)3.10551109
87cAMP catabolic process (GO:0006198)3.10361581
88regulation of clathrin-mediated endocytosis (GO:2000369)3.09572995
89mating behavior (GO:0007617)3.09451123
90membrane depolarization during action potential (GO:0086010)3.08953683
91positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06462633
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03083753
93transmission of nerve impulse (GO:0019226)3.02547527
94negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01983274
95regulation of synaptic transmission, glutamatergic (GO:0051966)3.01818009
96potassium ion import (GO:0010107)3.01592995
97organelle transport along microtubule (GO:0072384)3.00807324
98long-term synaptic potentiation (GO:0060291)3.00767318
99neuron recognition (GO:0008038)3.00111950
100regulation of neurotransmitter transport (GO:0051588)2.99707150
101pore complex assembly (GO:0046931)2.98687175
102positive regulation of neurotransmitter transport (GO:0051590)2.98663774
103response to auditory stimulus (GO:0010996)2.97881649
104auditory behavior (GO:0031223)2.97673595
105viral mRNA export from host cell nucleus (GO:0046784)2.97210529
106generation of neurons (GO:0048699)2.95731820
107membrane depolarization (GO:0051899)2.95371157
108cellular sodium ion homeostasis (GO:0006883)2.95265000
109gamma-aminobutyric acid signaling pathway (GO:0007214)2.94400799
110neuromuscular process (GO:0050905)2.92281819
111histone-serine phosphorylation (GO:0035404)2.90724874
112regulation of relaxation of muscle (GO:1901077)2.90460804
113positive regulation of neurotransmitter secretion (GO:0001956)2.90413305
114cerebellar granule cell differentiation (GO:0021707)2.90314490
115regulation of vesicle fusion (GO:0031338)2.90062999
116negative regulation of epithelial to mesenchymal transition (GO:0010719)2.89985796
117intraspecies interaction between organisms (GO:0051703)2.88772435
118social behavior (GO:0035176)2.88772435
119membrane hyperpolarization (GO:0060081)2.88621415
120regulation of centriole replication (GO:0046599)2.87987563
121axon cargo transport (GO:0008088)2.87921861
122cerebellar Purkinje cell layer development (GO:0021680)2.85300931
123peptidyl-lysine dimethylation (GO:0018027)2.85051519
124histone H2A monoubiquitination (GO:0035518)2.84057169
125regulation of actin filament-based movement (GO:1903115)2.83951922
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.83610290
127spleen development (GO:0048536)2.83315622
128alanine transport (GO:0032328)2.81378543
129innervation (GO:0060384)2.81244606
130positive regulation of synaptic transmission (GO:0050806)2.79990407
131potassium ion homeostasis (GO:0055075)2.77756551
132positive regulation of potassium ion transmembrane transport (GO:1901381)2.77653363
133negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.77013886
134nucleus localization (GO:0051647)2.76379931
135regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76306058
136regulation of synaptic transmission (GO:0050804)2.76122984
137response to pheromone (GO:0019236)2.75809613
138behavioral response to cocaine (GO:0048148)2.75545325
139axonal fasciculation (GO:0007413)2.75351336
140protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.71217352
141positive regulation of cation channel activity (GO:2001259)2.70511183
142regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.68859907
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67941766
144cyclic nucleotide catabolic process (GO:0009214)2.66615185
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.65521138
146thymus development (GO:0048538)2.65281216
147centrosome duplication (GO:0051298)2.58971351
148establishment of nucleus localization (GO:0040023)2.58245615
149negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.58128246
150righting reflex (GO:0060013)2.57812699
151cytoplasmic mRNA processing body assembly (GO:0033962)2.56565791
152adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.55991693
153post-anal tail morphogenesis (GO:0036342)2.54987696
154cellular response to glucagon stimulus (GO:0071377)2.53685039
155regulation of centrosome cycle (GO:0046605)2.51742813
156response to caffeine (GO:0031000)2.50434520
157telomere maintenance via telomere lengthening (GO:0010833)2.49722266
158positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.45911604
159regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.45568641
160response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.42248251
161ribonucleoprotein complex disassembly (GO:0032988)2.39053917
162retina layer formation (GO:0010842)2.38774366
163histone monoubiquitination (GO:0010390)2.37267328
164cellular response to cholesterol (GO:0071397)2.36719431
165negative regulation of dendrite morphogenesis (GO:0050774)2.36692021
166DNA integration (GO:0015074)2.33490835
167inositol metabolic process (GO:0006020)2.33036211
168positive regulation of dendritic spine morphogenesis (GO:0061003)2.32713156
169positive regulation of vascular permeability (GO:0043117)2.31568988
170prenylation (GO:0097354)2.30554328
171protein prenylation (GO:0018342)2.30554328
172regulation of glucose import in response to insulin stimulus (GO:2001273)2.29974809
173negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.29320806
174negative regulation of epithelial cell differentiation (GO:0030857)2.29094484
175protein localization to chromosome, centromeric region (GO:0071459)2.28688636
176innate immune response in mucosa (GO:0002227)2.28505205
177regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.27534444
178nucleosome assembly (GO:0006334)2.27065967
179regulation of centrosome duplication (GO:0010824)2.24538786
180mitotic chromosome condensation (GO:0007076)2.23679637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.66597157
2EZH2_22144423_ChIP-Seq_EOC_Human5.50329383
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.04663241
4E2F7_22180533_ChIP-Seq_HELA_Human3.38821166
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94407250
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88440849
7GBX2_23144817_ChIP-Seq_PC3_Human2.80857813
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80430603
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71837555
10REST_21632747_ChIP-Seq_MESCs_Mouse2.67980661
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.64790882
12AR_21909140_ChIP-Seq_LNCAP_Human2.64165557
13DROSHA_22980978_ChIP-Seq_HELA_Human2.58685686
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53791543
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52362808
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52362808
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50562978
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48808989
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.40111950
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36625441
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32573084
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.29295169
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23733706
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17674740
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17291147
26AR_21572438_ChIP-Seq_LNCaP_Human2.16716306
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14073455
28FUS_26573619_Chip-Seq_HEK293_Human2.12491820
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11682064
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08661897
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.07874577
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.01461129
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.5956605
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97462595
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.96532207
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94018748
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87368359
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.86475652
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84668826
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83707019
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81879066
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.77241371
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75923253
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.72589317
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51836086
46SMAD4_21799915_ChIP-Seq_A2780_Human1.50008891
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48442240
48* ZNF274_21170338_ChIP-Seq_K562_Hela1.48315763
49TAF15_26573619_Chip-Seq_HEK293_Human1.44580343
50KDM2B_26808549_Chip-Seq_K562_Human1.44577069
51* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43635260
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39547063
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39067963
54MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.38548207
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36605695
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35542044
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33942261
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31982232
59* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31237012
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.30485099
61AR_19668381_ChIP-Seq_PC3_Human1.28638503
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27556721
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26358049
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25251016
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24988660
66* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24682676
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.24058846
68* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24043720
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19683742
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18335261
71IRF1_19129219_ChIP-ChIP_H3396_Human1.16815615
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16321074
73* STAT3_23295773_ChIP-Seq_U87_Human1.15622263
74* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15004085
75* AR_25329375_ChIP-Seq_VCAP_Human1.14132995
76* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13815510
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12579804
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11781143
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11528774
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11024961
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09468324
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08836117
83SOX9_26525672_Chip-Seq_HEART_Mouse1.08606106
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05670330
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05315395
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05315395
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.04701769
88* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04005113
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03970124
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.03540173
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01757145
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01494795
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00568763
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00474173
95CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99282602
96TCF4_23295773_ChIP-Seq_U87_Human0.99195545
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98782848
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98671763
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97532776
100* P300_19829295_ChIP-Seq_ESCs_Human0.96900254
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96867629
102* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96707724
103* RING1B_27294783_Chip-Seq_NPCs_Mouse0.96329698
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.95952118
105* SMAD3_21741376_ChIP-Seq_EPCs_Human0.95666439
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95248691
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95193296
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94959831
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94477524
110SALL1_21062744_ChIP-ChIP_HESCs_Human0.94022190
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93864357
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.93834145
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.93131279
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93000047
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92982139
116TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92835166
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92737300
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92665260
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92240656
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91960395
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.91814475
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91779392
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.91520117
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90970655
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90926289
126* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90380963
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90239997
128AHR_22903824_ChIP-Seq_MCF-7_Human0.89865572
129SOX2_16153702_ChIP-ChIP_HESCs_Human0.89185207
130ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87654472
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87646693
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87383547
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87285633
134KLF4_19829295_ChIP-Seq_ESCs_Human0.87233534
135ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87216036
136FLI1_21867929_ChIP-Seq_TH2_Mouse0.87013455
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86537078
138RXR_22108803_ChIP-Seq_LS180_Human0.86145135
139POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.85911370
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85236682
141RUNX2_22187159_ChIP-Seq_PCA_Human0.84383157
142* TP53_16413492_ChIP-PET_HCT116_Human0.84304854
143VDR_22108803_ChIP-Seq_LS180_Human0.83784456
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82132555
145IGF1R_20145208_ChIP-Seq_DFB_Human0.82071527
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82026803
147CTCF_27219007_Chip-Seq_Bcells_Human0.80890469
148TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80302061
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80176787
150* SMAD4_21741376_ChIP-Seq_EPCs_Human0.79614131
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79584204
152FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78900414
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78631002
154SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78152335
155HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77643358
156REST_19997604_ChIP-ChIP_NEURONS_Mouse0.77206228
157EWS_26573619_Chip-Seq_HEK293_Human0.73807398
158NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73517457
159RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72906375
160* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.72868291
161MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.72678319
162SOX17_20123909_ChIP-Seq_XEN_Mouse0.71927220
163GATA1_22025678_ChIP-Seq_K562_Human0.71916206
164TBX3_20139965_ChIP-Seq_ESCs_Mouse0.71395287
165TBX3_20139965_ChIP-Seq_MESCs_Mouse0.71336085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.56349763
2MP0003880_abnormal_central_pattern4.31143261
3* MP0003635_abnormal_synaptic_transmissio4.18556148
4MP0004270_analgesia3.74563251
5MP0009046_muscle_twitch3.37487308
6MP0009745_abnormal_behavioral_response3.33280133
7MP0002064_seizures3.18823097
8MP0002063_abnormal_learning/memory/cond3.18277835
9MP0000749_muscle_degeneration3.09518157
10MP0001968_abnormal_touch/_nociception3.02499985
11MP0008057_abnormal_DNA_replication2.99854356
12MP0005423_abnormal_somatic_nervous2.86123891
13MP0002572_abnormal_emotion/affect_behav2.62207871
14MP0002734_abnormal_mechanical_nocicepti2.58964071
15MP0002009_preneoplasia2.57288489
16MP0002272_abnormal_nervous_system2.57188182
17MP0001486_abnormal_startle_reflex2.49710154
18MP0002822_catalepsy2.45743007
19MP0009780_abnormal_chondrocyte_physiolo2.37854988
20MP0003329_amyloid_beta_deposits2.37321648
21MP0003693_abnormal_embryo_hatching2.26035958
22MP0004185_abnormal_adipocyte_glucose2.20907831
23MP0002735_abnormal_chemical_nociception2.19564261
24MP0002736_abnormal_nociception_after2.17753345
25MP0001501_abnormal_sleep_pattern2.14878714
26MP0002733_abnormal_thermal_nociception2.07060475
27MP0002909_abnormal_adrenal_gland2.07018903
28MP0004858_abnormal_nervous_system2.04608376
29MP0001440_abnormal_grooming_behavior2.02010248
30MP0002067_abnormal_sensory_capabilities2.01237483
31MP0010094_abnormal_chromosome_stability2.00544504
32MP0008569_lethality_at_weaning1.99873895
33MP0001970_abnormal_pain_threshold1.91116542
34MP0004811_abnormal_neuron_physiology1.88806882
35MP0005386_behavior/neurological_phenoty1.82130287
36MP0004924_abnormal_behavior1.82130287
37MP0002269_muscular_atrophy1.79740319
38MP0002184_abnormal_innervation1.70063930
39MP0002557_abnormal_social/conspecific_i1.69848893
40MP0006276_abnormal_autonomic_nervous1.61080180
41MP0003879_abnormal_hair_cell1.58936126
42MP0000955_abnormal_spinal_cord1.55915280
43MP0004885_abnormal_endolymph1.54874078
44MP0000569_abnormal_digit_pigmentation1.49881337
45MP0005646_abnormal_pituitary_gland1.49453400
46MP0000537_abnormal_urethra_morphology1.48944437
47MP0003633_abnormal_nervous_system1.46877299
48MP0001915_intracranial_hemorrhage1.46705471
49MP0000778_abnormal_nervous_system1.42751373
50MP0002066_abnormal_motor_capabilities/c1.42362136
51MP0002882_abnormal_neuron_morphology1.33718847
52MP0000751_myopathy1.33541512
53MP0002638_abnormal_pupillary_reflex1.31451548
54MP0000604_amyloidosis1.31308876
55MP0004957_abnormal_blastocyst_morpholog1.26792053
56MP0003077_abnormal_cell_cycle1.25398473
57MP0003631_nervous_system_phenotype1.24354569
58MP0004142_abnormal_muscle_tone1.22712547
59MP0001984_abnormal_olfaction1.21691330
60MP0010352_gastrointestinal_tract_polyps1.20421799
61MP0008770_decreased_survivor_rate1.16715147
62MP0003787_abnormal_imprinting1.16183644
63MP0008961_abnormal_basal_metabolism1.14602591
64MP0005645_abnormal_hypothalamus_physiol1.14552635
65MP0003183_abnormal_peptide_metabolism1.14152249
66MP0003123_paternal_imprinting1.13890284
67MP0003122_maternal_imprinting1.13828817
68MP0000013_abnormal_adipose_tissue1.13420360
69MP0003690_abnormal_glial_cell1.12776887
70MP0004145_abnormal_muscle_electrophysio1.11473780
71MP0003111_abnormal_nucleus_morphology1.11365275
72MP0008874_decreased_physiological_sensi1.10427749
73MP0003861_abnormal_nervous_system1.09044595
74MP0001502_abnormal_circadian_rhythm1.08626324
75MP0002229_neurodegeneration1.07825315
76MP0004087_abnormal_muscle_fiber1.06222736
77MP0000733_abnormal_muscle_development1.05308408
78MP0002084_abnormal_developmental_patter1.04305854
79MP0002877_abnormal_melanocyte_morpholog1.03457105
80MP0003937_abnormal_limbs/digits/tail_de1.03036868
81MP0005535_abnormal_body_temperature1.02636769
82MP0005076_abnormal_cell_differentiation1.02444945
83MP0003646_muscle_fatigue1.00628551
84MP0004130_abnormal_muscle_cell0.99724079
85MP0003315_abnormal_perineum_morphology0.99471280
86MP0004036_abnormal_muscle_relaxation0.99020543
87MP0002152_abnormal_brain_morphology0.99010092
88MP0000759_abnormal_skeletal_muscle0.97958126
89* MP0003221_abnormal_cardiomyocyte_apopto0.97364614
90* MP0008872_abnormal_physiological_respon0.96748283
91MP0003632_abnormal_nervous_system0.96733858
92MP0002069_abnormal_eating/drinking_beha0.95668402
93MP0005666_abnormal_adipose_tissue0.94560991
94MP0002234_abnormal_pharynx_morphology0.92789747
95MP0003075_altered_response_to0.92185197
96MP0002332_abnormal_exercise_endurance0.92065590
97MP0002837_dystrophic_cardiac_calcinosis0.88977510
98MP0002081_perinatal_lethality0.87868224
99MP0001661_extended_life_span0.85715070
100MP0002139_abnormal_hepatobiliary_system0.85653932
101MP0001905_abnormal_dopamine_level0.85626288
102MP0003121_genomic_imprinting0.84777706
103MP0003634_abnormal_glial_cell0.84744879
104MP0004742_abnormal_vestibular_system0.84579950
105MP0000920_abnormal_myelination0.84217175
106MP0000003_abnormal_adipose_tissue0.83598095
107MP0010386_abnormal_urinary_bladder0.83238732
108MP0003283_abnormal_digestive_organ0.82351237
109MP0004085_abnormal_heartbeat0.82211746
110MP0004233_abnormal_muscle_weight0.81205620
111MP0001879_abnormal_lymphatic_vessel0.80303555
112MP0001529_abnormal_vocalization0.79651844
113MP0009697_abnormal_copulation0.79053494
114MP0005083_abnormal_biliary_tract0.77611707
115MP0003172_abnormal_lysosome_physiology0.76194154
116MP0002082_postnatal_lethality0.75426409
117MP0010770_preweaning_lethality0.75426409
118MP0003868_abnormal_feces_composition0.73810389
119MP0000428_abnormal_craniofacial_morphol0.73676397
120MP0001177_atelectasis0.73189407
121MP0002090_abnormal_vision0.73069978
122MP0004197_abnormal_fetal_growth/weight/0.72905948
123MP0005409_darkened_coat_color0.72865011
124MP0000747_muscle_weakness0.72850489
125MP0008007_abnormal_cellular_replicative0.72550931
126MP0002160_abnormal_reproductive_system0.72307588
127MP0004215_abnormal_myocardial_fiber0.69517420
128MP0010234_abnormal_vibrissa_follicle0.68205707
129MP0005551_abnormal_eye_electrophysiolog0.67334601
130MP0001299_abnormal_eye_distance/0.66615907
131MP0005167_abnormal_blood-brain_barrier0.62400133
132MP0003137_abnormal_impulse_conducting0.58828885
133MP0004043_abnormal_pH_regulation0.58152061
134MP0001963_abnormal_hearing_physiology0.57400940
135MP0005623_abnormal_meninges_morphology0.57201705
136MP0001664_abnormal_digestion0.54916821
137MP0005187_abnormal_penis_morphology0.54335101
138MP0002752_abnormal_somatic_nervous0.54187403
139MP0004510_myositis0.54055193
140MP0001348_abnormal_lacrimal_gland0.53969287
141MP0003956_abnormal_body_size0.53310817
142MP0003045_fibrosis0.52693455
143MP0004484_altered_response_of0.51463807
144MP0010769_abnormal_survival0.51439655
145MP0000639_abnormal_adrenal_gland0.51434584
146MP0005448_abnormal_energy_balance0.50246293
147MP0010329_abnormal_lipoprotein_level0.49979836

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.54454275
2Focal motor seizures (HP:0011153)6.45858947
3Calf muscle hypertrophy (HP:0008981)5.40460400
4Focal seizures (HP:0007359)5.28339905
5Visual hallucinations (HP:0002367)5.04075771
6Cerebellar dysplasia (HP:0007033)4.80189659
7Muscle hypertrophy of the lower extremities (HP:0008968)4.77299108
8Action tremor (HP:0002345)4.61760495
9Type II lissencephaly (HP:0007260)4.29067468
10Progressive cerebellar ataxia (HP:0002073)4.28217736
11Atonic seizures (HP:0010819)4.09857513
12Epileptic encephalopathy (HP:0200134)4.01519648
13Pelvic girdle muscle weakness (HP:0003749)4.01369588
14Supranuclear gaze palsy (HP:0000605)3.97969933
15Shoulder girdle muscle weakness (HP:0003547)3.97063430
16Frequent falls (HP:0002359)3.92311292
17Limb-girdle muscle atrophy (HP:0003797)3.83227861
18Absence seizures (HP:0002121)3.78781936
19Short femoral neck (HP:0100864)3.78319780
20Febrile seizures (HP:0002373)3.77096646
21Generalized tonic-clonic seizures (HP:0002069)3.70316267
22Difficulty climbing stairs (HP:0003551)3.69338612
23Hypoplasia of the pons (HP:0012110)3.66421496
24Abnormality of the hip-girdle musculature (HP:0001445)3.66297930
25Abnormality of the musculature of the pelvis (HP:0001469)3.66297930
26Ankle clonus (HP:0011448)3.64935217
27Rough bone trabeculation (HP:0100670)3.54046225
28Abnormality of the pons (HP:0007361)3.46728250
29Papilledema (HP:0001085)3.46597282
30Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.43195628
31Poor eye contact (HP:0000817)3.42919389
32Depression (HP:0000716)3.40399131
33Postural instability (HP:0002172)3.33374208
34Impaired social interactions (HP:0000735)3.33151169
35Abnormal social behavior (HP:0012433)3.33151169
36Achilles tendon contracture (HP:0001771)3.32316283
37Dialeptic seizures (HP:0011146)3.29163449
38Impaired vibration sensation in the lower limbs (HP:0002166)3.28385443
39Vertebral arch anomaly (HP:0008438)3.26624708
40Abnormality of the lower motor neuron (HP:0002366)3.20404707
41Urinary bladder sphincter dysfunction (HP:0002839)3.20265594
42Anomalous pulmonary venous return (HP:0010772)3.19552167
43Dysdiadochokinesis (HP:0002075)3.19224190
44Aplasia/hypoplasia of the femur (HP:0005613)3.16707769
45Pathologic fracture (HP:0002756)3.13163296
46Gaze-evoked nystagmus (HP:0000640)3.10003791
47Abnormality of the Achilles tendon (HP:0005109)3.07238681
48Anxiety (HP:0000739)3.04801514
49Impaired smooth pursuit (HP:0007772)3.03538050
50Mutism (HP:0002300)3.01130109
51Broad-based gait (HP:0002136)2.98591490
52Premature graying of hair (HP:0002216)2.96893967
53Truncal ataxia (HP:0002078)2.96333257
54Urinary urgency (HP:0000012)2.95094886
55Dysmetria (HP:0001310)2.92360770
56Dysmetric saccades (HP:0000641)2.89827059
57Pheochromocytoma (HP:0002666)2.89702167
58Torticollis (HP:0000473)2.89369322
59Upper motor neuron abnormality (HP:0002127)2.88502846
60Abnormal eating behavior (HP:0100738)2.87604113
61Scanning speech (HP:0002168)2.86722372
62Leukodystrophy (HP:0002415)2.86490853
63Genetic anticipation (HP:0003743)2.84114128
64Status epilepticus (HP:0002133)2.81405320
65Hemiplegia (HP:0002301)2.79283214
66Abnormality of the calf musculature (HP:0001430)2.79045036
67Intention tremor (HP:0002080)2.77557983
68Abnormality of the pulmonary veins (HP:0011718)2.74769207
69Abnormality of ocular smooth pursuit (HP:0000617)2.73906882
70Termporal pattern (HP:0011008)2.72978100
71Insidious onset (HP:0003587)2.72978100
72Hyperventilation (HP:0002883)2.71906374
73Death in childhood (HP:0003819)2.68282750
74Abnormal trabecular bone morphology (HP:0100671)2.64887297
75Spastic gait (HP:0002064)2.64645659
76Focal dystonia (HP:0004373)2.58771818
77Bradykinesia (HP:0002067)2.58223989
78Progressive inability to walk (HP:0002505)2.56164861
79Ventricular fibrillation (HP:0001663)2.51358701
80Excessive salivation (HP:0003781)2.49048974
81Drooling (HP:0002307)2.49048974
82Cerebral inclusion bodies (HP:0100314)2.45974851
83Myoglobinuria (HP:0002913)2.45921613
84Abnormality of the corticospinal tract (HP:0002492)2.45575593
85Craniofacial dystonia (HP:0012179)2.42947293
86Neuroendocrine neoplasm (HP:0100634)2.41447794
87Neurofibrillary tangles (HP:0002185)2.40366235
88Vertebral fusion (HP:0002948)2.39491592
89Agitation (HP:0000713)2.38487506
90EMG: myopathic abnormalities (HP:0003458)2.36609742
91Limb dystonia (HP:0002451)2.33640396
92Impaired vibratory sensation (HP:0002495)2.33117305
93Hemiparesis (HP:0001269)2.31134634
94Insomnia (HP:0100785)2.26361709
95Hypoplasia of the brainstem (HP:0002365)2.25119620
96Aplasia/Hypoplasia of the brainstem (HP:0007362)2.25119620
97Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.24904568
98EEG with generalized epileptiform discharges (HP:0011198)2.23554672
99Clonus (HP:0002169)2.23323576
100Epileptiform EEG discharges (HP:0011182)2.23242357
101Hypoventilation (HP:0002791)2.22268422
102Tetraplegia (HP:0002445)2.21857198
103Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20436595
104Amblyopia (HP:0000646)2.20135500
105Hypsarrhythmia (HP:0002521)2.17708326
106Delayed gross motor development (HP:0002194)2.15805857
107Abnormality of saccadic eye movements (HP:0000570)2.15665737
108Stereotypic behavior (HP:0000733)2.15252721
109Diplopia (HP:0000651)2.14573730
110Abnormality of binocular vision (HP:0011514)2.14573730
111Lower limb muscle weakness (HP:0007340)2.13228122
112Neuronal loss in central nervous system (HP:0002529)2.10845848
113Postural tremor (HP:0002174)2.10461285
114Neoplasm of the peripheral nervous system (HP:0100007)2.09712767
115Papillary thyroid carcinoma (HP:0002895)2.09604566
116Amyotrophic lateral sclerosis (HP:0007354)2.08531467
117Generalized myoclonic seizures (HP:0002123)2.04308532
118Rigidity (HP:0002063)2.02829546
119CNS hypomyelination (HP:0003429)2.01629103
120Resting tremor (HP:0002322)2.01307024
121Gait ataxia (HP:0002066)2.00877880
122Oral leukoplakia (HP:0002745)10.2209231
123Pointed chin (HP:0000307)1.99580949
124Macroorchidism (HP:0000053)1.98949896
125Cellular immunodeficiency (HP:0005374)1.96567453
126Blue irides (HP:0000635)1.96436736
127Megalencephaly (HP:0001355)1.95213752
128Limb-girdle muscle weakness (HP:0003325)1.95056902
129Abnormality of the periventricular white matter (HP:0002518)1.94674411
130Postnatal growth retardation (HP:0008897)1.94470480
131Hypercortisolism (HP:0001578)1.93729387
132Bundle branch block (HP:0011710)1.93437917
133Fibular aplasia (HP:0002990)1.92375260
134Polyphagia (HP:0002591)1.91104393
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90456988
136Morphological abnormality of the pyramidal tract (HP:0002062)1.88537125
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87985237
138Degeneration of the lateral corticospinal tracts (HP:0002314)1.87985237
139Annular pancreas (HP:0001734)1.87729313
140Psychosis (HP:0000709)1.83955766
141Rapidly progressive (HP:0003678)1.82034781
142Meningocele (HP:0002435)1.81542803
143Hyporeflexia of lower limbs (HP:0002600)1.80952711
144Absent speech (HP:0001344)1.80812432
145Failure to thrive in infancy (HP:0001531)1.79731133
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79162494
147Abnormality of alanine metabolism (HP:0010916)1.79162494
148Hyperalaninemia (HP:0003348)1.79162494
149Inappropriate behavior (HP:0000719)1.78567471
150Fetal akinesia sequence (HP:0001989)1.78149316
151Inability to walk (HP:0002540)1.77214933
152Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76070842
153Protruding tongue (HP:0010808)1.74501815
154Akinesia (HP:0002304)1.74114053
155Medulloblastoma (HP:0002885)1.71304635
156Proximal amyotrophy (HP:0007126)1.68965719
157Difficulty running (HP:0009046)1.65366399
158Neoplasm of the pancreas (HP:0002894)1.65143347
159Abnormality of the shoulder girdle musculature (HP:0001435)1.64915165
160Severe muscular hypotonia (HP:0006829)1.64515508
161Subaortic stenosis (HP:0001682)1.63146761
162Abnormality of the left ventricular outflow tract (HP:0011103)1.63146761
163Missing ribs (HP:0000921)1.62851483
164Intellectual disability, profound (HP:0002187)1.62541915
165Spastic tetraparesis (HP:0001285)1.60928872
166Broad ribs (HP:0000885)1.60765589
167Nemaline bodies (HP:0003798)1.60179550
168Neoplasm of the heart (HP:0100544)1.57008147
169Sparse lateral eyebrow (HP:0005338)1.56935715
170Menstrual irregularities (HP:0000858)1.56710190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.48865497
2BLK4.38954788
3MAP3K94.08239812
4NTRK34.07386022
5ZAK3.62355461
6MARK13.19723617
7EPHA43.11253373
8MINK13.02946403
9DAPK22.62476476
10CDC72.43970197
11PAK62.38603996
12* MAP3K42.38577105
13CAMKK12.35461300
14KSR22.28689166
15PRKD32.20380841
16NTRK22.10248921
17EEF2K2.08666342
18VRK12.06133705
19MAP3K121.99547828
20NTRK11.97699727
21EPHA31.97190121
22* MAP2K41.82490992
23CAMKK21.80001059
24STK381.72311586
25CDK51.53568967
26EIF2AK31.51232988
27ERBB31.48340560
28TSSK61.47734997
29SRPK11.46399421
30NEK91.42828755
31AKT31.42431069
32CAMK1G1.39932485
33LATS21.39410443
34KSR11.38294122
35MAP3K21.35734032
36DAPK11.35691609
37PNCK1.34816636
38PHKG11.34382045
39PHKG21.34382045
40STK391.30240692
41TYRO31.30150045
42GRK51.25919663
43CDK191.25795479
44LMTK21.23680484
45RIPK41.23656436
46RPS6KA51.22364427
47AURKA1.20103999
48TAOK11.17354363
49MKNK21.16092099
50OBSCN1.15584912
51MAPK131.14640362
52PRKCG1.14466907
53SIK21.14405757
54PINK11.13859539
55RIPK11.13200632
56SCYL21.13137149
57* MAP2K71.12363500
58PBK1.11625185
59TNIK1.10697709
60PLK21.09667219
61PRKCH1.07985975
62BRSK21.05684430
63ALK1.05533558
64FES1.04216854
65ILK1.01944835
66UHMK10.99578518
67MAP3K130.99544904
68CAMK10.99195605
69* RET0.98132113
70ERBB40.96966822
71MST1R0.95097705
72SGK2230.94920894
73SGK4940.94920894
74WNK10.94868450
75SGK30.94780114
76PKN10.94371981
77STK110.91457171
78SGK20.87553006
79WNK40.87103105
80RPS6KB20.86489463
81BRAF0.85425161
82CDK150.84202038
83CDK180.83491403
84ARAF0.83224977
85AURKB0.82749729
86CDK140.82338937
87BRSK10.81854663
88CASK0.81168147
89CSNK1G20.80193451
90PDK10.79550274
91PAK30.78625037
92RPS6KB10.77313807
93NEK10.77067957
94CAMK2A0.75196466
95PDPK10.74177624
96CAMK1D0.72913259
97TRIB30.72718995
98MARK20.72067555
99CDK11A0.71607224
100MAP3K70.70717985
101MET0.69661795
102NEK20.69657989
103MAP3K10.67151710
104TNK20.66700379
105EIF2AK10.66673599
106PRKAA10.63435061
107STK40.61270995
108MAPKAPK30.60078548
109SGK10.59930732
110RAF10.59701184
111CDC42BPA0.57277604
112CCNB10.56639667
113PTK2B0.55222844
114RPS6KA30.53656403
115PRKCZ0.53312043
116PDGFRB0.53113261
117CSNK1E0.52721925
118PKN20.52713373
119ICK0.51485402
120PRKCI0.51296064
121PDGFRA0.50883218
122PDK40.49310361
123PDK30.49310361
124TTK0.49049864
125CAMK2G0.48806588
126FYN0.48539513
127MAPK100.48250224
128CAMK40.48172650
129DYRK1A0.48159934
130CHEK10.45694441
131CAMK2B0.45155622
132FER0.45138234
133PLK10.44507555
134TRPM70.43321715
135OXSR10.43258615
136MAP2K10.42818429
137MAPK90.42683407
138MAPK120.39235294
139ACVR1B0.39181818
140CDK10.38444581
141RPS6KA20.38077033
142FGFR30.37878902
143PRPF4B0.37688336
144FGFR20.37389230
145WNK30.36955594
146MAPKAPK50.36644332
147PRKCE0.33629963
148DAPK30.32121446
149CDK20.31159995
150CDK120.30744838
151ABL20.30422432
152ATM0.30247823

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.71253055
2Synaptic vesicle cycle_Homo sapiens_hsa047213.23141683
3Nicotine addiction_Homo sapiens_hsa050333.10064208
4Nitrogen metabolism_Homo sapiens_hsa009102.64463659
5GABAergic synapse_Homo sapiens_hsa047272.52274532
6Olfactory transduction_Homo sapiens_hsa047402.46304375
7Long-term potentiation_Homo sapiens_hsa047202.37212400
8Circadian entrainment_Homo sapiens_hsa047132.35972321
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35242609
10Glutamatergic synapse_Homo sapiens_hsa047242.25115574
11* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21995786
12Morphine addiction_Homo sapiens_hsa050322.16664414
13Amphetamine addiction_Homo sapiens_hsa050312.14682209
14Salivary secretion_Homo sapiens_hsa049701.96184264
15* Dopaminergic synapse_Homo sapiens_hsa047281.95230681
16Insulin secretion_Homo sapiens_hsa049111.89099513
17Gastric acid secretion_Homo sapiens_hsa049711.84208108
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83891907
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79457911
20Cholinergic synapse_Homo sapiens_hsa047251.74315720
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65659730
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64258952
23Viral carcinogenesis_Homo sapiens_hsa052031.61936611
24Renin secretion_Homo sapiens_hsa049241.53280660
25Cocaine addiction_Homo sapiens_hsa050301.50215677
26Oxytocin signaling pathway_Homo sapiens_hsa049211.49403655
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46916489
28Taste transduction_Homo sapiens_hsa047421.45691313
29Long-term depression_Homo sapiens_hsa047301.45205967
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41566538
31Nucleotide excision repair_Homo sapiens_hsa034201.36204034
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35104313
33Calcium signaling pathway_Homo sapiens_hsa040201.32035293
34* GnRH signaling pathway_Homo sapiens_hsa049121.29710888
35Gap junction_Homo sapiens_hsa045401.27791074
36Serotonergic synapse_Homo sapiens_hsa047261.22107393
37* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18354469
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17960462
39Estrogen signaling pathway_Homo sapiens_hsa049151.16413430
40Glioma_Homo sapiens_hsa052141.13489458
41* Type II diabetes mellitus_Homo sapiens_hsa049301.13077022
42* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11530268
43* cAMP signaling pathway_Homo sapiens_hsa040241.09831117
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09407455
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08781866
46RNA polymerase_Homo sapiens_hsa030201.03886267
47Bile secretion_Homo sapiens_hsa049761.02411493
48Dorso-ventral axis formation_Homo sapiens_hsa043201.01164339
49Arginine biosynthesis_Homo sapiens_hsa002201.00360138
50Collecting duct acid secretion_Homo sapiens_hsa049660.93537081
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92028558
52* ErbB signaling pathway_Homo sapiens_hsa040120.91063673
53Chronic myeloid leukemia_Homo sapiens_hsa052200.90560625
54DNA replication_Homo sapiens_hsa030300.88179786
55Thyroid hormone synthesis_Homo sapiens_hsa049180.85041137
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84172073
57Cell cycle_Homo sapiens_hsa041100.83264256
58Pancreatic secretion_Homo sapiens_hsa049720.83250237
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83132511
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82331826
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.82121072
62Melanogenesis_Homo sapiens_hsa049160.81029175
63Axon guidance_Homo sapiens_hsa043600.79003623
64Oocyte meiosis_Homo sapiens_hsa041140.78078287
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.77431231
66Glucagon signaling pathway_Homo sapiens_hsa049220.75082515
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74892572
68Spliceosome_Homo sapiens_hsa030400.74125550
69Purine metabolism_Homo sapiens_hsa002300.72919003
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71427737
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70929110
72mTOR signaling pathway_Homo sapiens_hsa041500.70069771
73Butanoate metabolism_Homo sapiens_hsa006500.67951888
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67934404
75RNA transport_Homo sapiens_hsa030130.66661118
76Selenocompound metabolism_Homo sapiens_hsa004500.66639894
77Cardiac muscle contraction_Homo sapiens_hsa042600.66546346
78* Neurotrophin signaling pathway_Homo sapiens_hsa047220.65840871
79Platelet activation_Homo sapiens_hsa046110.65754045
80Dilated cardiomyopathy_Homo sapiens_hsa054140.64925618
81Hippo signaling pathway_Homo sapiens_hsa043900.63335833
82Prion diseases_Homo sapiens_hsa050200.61919106
83* Insulin signaling pathway_Homo sapiens_hsa049100.61744108
84mRNA surveillance pathway_Homo sapiens_hsa030150.61221847
85Vibrio cholerae infection_Homo sapiens_hsa051100.60900856
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60258650
87VEGF signaling pathway_Homo sapiens_hsa043700.60157552
88* Pancreatic cancer_Homo sapiens_hsa052120.59585815
89* MAPK signaling pathway_Homo sapiens_hsa040100.59150787
90* Colorectal cancer_Homo sapiens_hsa052100.57412205
91* Choline metabolism in cancer_Homo sapiens_hsa052310.57365801
92Melanoma_Homo sapiens_hsa052180.57163924
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56130849
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54419418
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54237676
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53877327
97Fatty acid biosynthesis_Homo sapiens_hsa000610.53568547
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53484396
99Endocytosis_Homo sapiens_hsa041440.52194620
100Endometrial cancer_Homo sapiens_hsa052130.51674093
101Inositol phosphate metabolism_Homo sapiens_hsa005620.50824326
102Small cell lung cancer_Homo sapiens_hsa052220.50393172
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48684100
104Non-small cell lung cancer_Homo sapiens_hsa052230.48480521
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48407555
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47752079
107* FoxO signaling pathway_Homo sapiens_hsa040680.46762571
108Rap1 signaling pathway_Homo sapiens_hsa040150.45868215
109* Prolactin signaling pathway_Homo sapiens_hsa049170.45834436
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.45315462
111Fanconi anemia pathway_Homo sapiens_hsa034600.44264417
112* Sphingolipid signaling pathway_Homo sapiens_hsa040710.42395504
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42330826
114* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41399672
115* Ras signaling pathway_Homo sapiens_hsa040140.41118112
116* Pathways in cancer_Homo sapiens_hsa052000.38867463
117Sulfur metabolism_Homo sapiens_hsa009200.38542084
118Pyrimidine metabolism_Homo sapiens_hsa002400.38152018
119Phototransduction_Homo sapiens_hsa047440.36379018
120Renal cell carcinoma_Homo sapiens_hsa052110.36081415
121AMPK signaling pathway_Homo sapiens_hsa041520.35945174
122Regulation of autophagy_Homo sapiens_hsa041400.35584015
123Ovarian steroidogenesis_Homo sapiens_hsa049130.35435738
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.34321991
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32146039
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32059770
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29536628
128Alcoholism_Homo sapiens_hsa050340.28426343
129Circadian rhythm_Homo sapiens_hsa047100.28392375
130Type I diabetes mellitus_Homo sapiens_hsa049400.28373996
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.27207210
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27130898

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