MAPKAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.72841393
2Golgi transport vesicle coating (GO:0048200)4.45752257
3COPI coating of Golgi vesicle (GO:0048205)4.45752257
4ethanol oxidation (GO:0006069)4.18458418
5regulation of early endosome to late endosome transport (GO:2000641)4.17447649
6sulfur amino acid catabolic process (GO:0000098)4.11741046
7barbed-end actin filament capping (GO:0051016)4.11376398
8lysine catabolic process (GO:0006554)4.06306303
9lysine metabolic process (GO:0006553)4.06306303
10focal adhesion assembly (GO:0048041)3.93426697
11cell-substrate adherens junction assembly (GO:0007045)3.93426697
12urea cycle (GO:0000050)3.92847133
13urea metabolic process (GO:0019627)3.92847133
14cysteine metabolic process (GO:0006534)3.91509395
15amyloid precursor protein catabolic process (GO:0042987)3.90809325
16stress fiber assembly (GO:0043149)3.86417264
17pinocytosis (GO:0006907)3.85986607
18adherens junction assembly (GO:0034333)3.84713011
19cell-substrate junction assembly (GO:0007044)3.75476883
20alpha-linolenic acid metabolic process (GO:0036109)3.74531254
21positive regulation of fatty acid beta-oxidation (GO:0032000)3.72433651
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.68393668
23axon extension involved in axon guidance (GO:0048846)3.68393668
24nitrogen cycle metabolic process (GO:0071941)3.64352739
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44205852
26regulation of fatty acid beta-oxidation (GO:0031998)3.40448984
27protein retention in ER lumen (GO:0006621)3.39940738
28growth hormone receptor signaling pathway (GO:0060396)3.37839291
29negative regulation of fibrinolysis (GO:0051918)3.37097173
30nuclear pore complex assembly (GO:0051292)3.33339430
31glyoxylate metabolic process (GO:0046487)3.31828973
32regulation of chromatin binding (GO:0035561)3.28823751
33regulation of glucose import in response to insulin stimulus (GO:2001273)3.28134613
34negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.27584982
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.26128250
36positive regulation of fatty acid oxidation (GO:0046321)3.26107854
37cellular protein complex localization (GO:0034629)3.23739592
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22462683
39regulation of sister chromatid cohesion (GO:0007063)3.22171854
40skin morphogenesis (GO:0043589)3.20211049
41regulation of transforming growth factor beta2 production (GO:0032909)3.17865359
42ethanol metabolic process (GO:0006067)3.15098943
43hemidesmosome assembly (GO:0031581)3.12727515
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.10035407
45embryonic process involved in female pregnancy (GO:0060136)3.07115968
46cytoskeletal anchoring at plasma membrane (GO:0007016)3.05501468
47high-density lipoprotein particle remodeling (GO:0034375)3.02482460
48regulation of NFAT protein import into nucleus (GO:0051532)3.01701952
49regulation of mammary gland epithelial cell proliferation (GO:0033599)2.99899928
50epithelial cell-cell adhesion (GO:0090136)2.99895167
51amino-acid betaine metabolic process (GO:0006577)2.95031589
52cell adhesion mediated by integrin (GO:0033627)2.94531258
53monoubiquitinated protein deubiquitination (GO:0035520)2.92949475
54regulation of fibrinolysis (GO:0051917)2.91961831
55protein insertion into membrane (GO:0051205)2.91803693
56positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.90432992
57acetyl-CoA metabolic process (GO:0006084)2.90235595
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88943515
59L-phenylalanine catabolic process (GO:0006559)2.88943515
60aromatic amino acid family catabolic process (GO:0009074)2.88834710
61cytoplasmic mRNA processing body assembly (GO:0033962)2.88278566
62serine family amino acid catabolic process (GO:0009071)2.87538752
63cortical actin cytoskeleton organization (GO:0030866)2.87015978
64DNA unwinding involved in DNA replication (GO:0006268)2.86120335
65cellular response to growth hormone stimulus (GO:0071378)2.84832815
66hypotonic response (GO:0006971)2.82905952
67apoptotic cell clearance (GO:0043277)2.80495797
68activation of Rac GTPase activity (GO:0032863)2.80120042
69protein complex localization (GO:0031503)2.79797627
70negative regulation of cell size (GO:0045792)2.78553944
71L-phenylalanine metabolic process (GO:0006558)2.77529395
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.77529395
73homocysteine metabolic process (GO:0050667)2.77031964
74phospholipid homeostasis (GO:0055091)2.75594550
75regulation of triglyceride catabolic process (GO:0010896)2.74803068
76endodermal cell differentiation (GO:0035987)2.73176911
77membrane raft organization (GO:0031579)2.72944580
78regulation of nucleobase-containing compound transport (GO:0032239)2.72515267
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71551445
80fatty acid transmembrane transport (GO:1902001)2.69305532
81hippo signaling (GO:0035329)2.68379707
82planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67695984
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67550069
84regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66742636
85piRNA metabolic process (GO:0034587)2.66481732
86positive regulation of Cdc42 GTPase activity (GO:0043089)2.65440052
87tryptophan catabolic process (GO:0006569)2.65398012
88indole-containing compound catabolic process (GO:0042436)2.65398012
89indolalkylamine catabolic process (GO:0046218)2.65398012
90positive regulation of lipid catabolic process (GO:0050996)2.64715081
913-UTR-mediated mRNA stabilization (GO:0070935)2.64616438
92positive regulation of triglyceride metabolic process (GO:0090208)2.64204271
93negative regulation of cholesterol transport (GO:0032375)2.63686192
94negative regulation of sterol transport (GO:0032372)2.63686192
95nuclear pore organization (GO:0006999)2.63536249
96flavonoid metabolic process (GO:0009812)2.63374131
97dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63310383
98glycine metabolic process (GO:0006544)2.63113654
99negative regulation of protein localization to plasma membrane (GO:1903077)2.62200411
100basement membrane organization (GO:0071711)2.62148940
101positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60849358
102activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60674910
103mitochondrial fusion (GO:0008053)2.59927374
104midgut development (GO:0007494)2.59851556
105macroautophagy (GO:0016236)2.59558682
106response to laminar fluid shear stress (GO:0034616)2.59156425
107metaphase plate congression (GO:0051310)2.58825482
108kynurenine metabolic process (GO:0070189)2.57883174
109regulation of translational fidelity (GO:0006450)2.57817817
110primary alcohol catabolic process (GO:0034310)2.57563990
111maternal placenta development (GO:0001893)2.55431571
112positive regulation of nuclease activity (GO:0032075)2.55091134
113regulation of centriole replication (GO:0046599)2.54554462
114spindle assembly involved in mitosis (GO:0090307)2.54442475
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.53945471
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53945471
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53945471
118carnitine shuttle (GO:0006853)2.53925148
119regulation of translational termination (GO:0006449)2.53601698
120mitotic chromosome condensation (GO:0007076)2.53182694
121tryptophan metabolic process (GO:0006568)2.53178907
122negative regulation of erythrocyte differentiation (GO:0045647)2.53178553
123modulation by symbiont of host cellular process (GO:0044068)2.52681498
124serine family amino acid metabolic process (GO:0009069)2.52544649
125regulation of RNA export from nucleus (GO:0046831)2.52527580
126one-carbon metabolic process (GO:0006730)2.52160220
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51137883
128hyaluronan catabolic process (GO:0030214)2.51086251
129mRNA stabilization (GO:0048255)2.51010993
130RNA stabilization (GO:0043489)2.51010993
131complement activation, alternative pathway (GO:0006957)2.50510168
132regulation of protein activation cascade (GO:2000257)2.49870901
133pyrimidine nucleobase catabolic process (GO:0006208)2.48645737
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.48285641
135reverse cholesterol transport (GO:0043691)2.46782326
136endoplasmic reticulum unfolded protein response (GO:0030968)2.46764068
137positive regulation of triglyceride biosynthetic process (GO:0010867)2.46541503
138positive regulation of endothelial cell apoptotic process (GO:2000353)2.45966030
139phospholipid efflux (GO:0033700)2.45926030
140short-chain fatty acid metabolic process (GO:0046459)2.45915264
141apoptotic process involved in morphogenesis (GO:0060561)2.45605741
142bile acid biosynthetic process (GO:0006699)2.44746169
143aspartate family amino acid catabolic process (GO:0009068)2.44691506
144cortical cytoskeleton organization (GO:0030865)2.44624034
145activation of MAPKKK activity (GO:0000185)2.44563986
146positive regulation of receptor recycling (GO:0001921)2.44238615
147positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.43684799
148peptidyl-glutamic acid carboxylation (GO:0017187)2.43499111
149protein carboxylation (GO:0018214)2.43499111
150regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43481016
151positive regulation of myotube differentiation (GO:0010831)2.42572307
152ER-nucleus signaling pathway (GO:0006984)2.42194161
153response to nitrosative stress (GO:0051409)2.41837143
154regulation of cholesterol biosynthetic process (GO:0045540)2.41710885
155pore complex assembly (GO:0046931)2.41351614
156regulation of fatty acid oxidation (GO:0046320)2.41324644
157gene silencing by RNA (GO:0031047)2.41320720
158negative regulation of anoikis (GO:2000811)2.41181499
159vesicle coating (GO:0006901)2.40978492
1602-oxoglutarate metabolic process (GO:0006103)2.40503625
161cellular glucuronidation (GO:0052695)2.40039989
162negative regulation of lipid transport (GO:0032369)2.39055372
163positive regulation of mitochondrial fission (GO:0090141)2.38847765
164regulation of cholesterol storage (GO:0010885)2.38662878
165microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.38600590
166epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38130255
167negative regulation of fatty acid biosynthetic process (GO:0045717)2.37639207
168pentose-phosphate shunt (GO:0006098)2.37630201
169fatty acid oxidation (GO:0019395)2.37530290
170vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.37276443
171carnitine metabolic process (GO:0009437)2.36325831
172cellular modified amino acid catabolic process (GO:0042219)2.35594980
173negative regulation of fatty acid transport (GO:2000192)2.35560532
174type B pancreatic cell proliferation (GO:0044342)2.35379800
175membrane protein ectodomain proteolysis (GO:0006509)2.35343992
176regulation of anoikis (GO:2000209)2.35060831
177protein-lipid complex assembly (GO:0065005)2.34598601
178actin filament bundle assembly (GO:0051017)2.34096058
179actin filament bundle organization (GO:0061572)2.34096058
180regulation of nuclease activity (GO:0032069)2.29039996
181protein hydroxylation (GO:0018126)2.28588662
182protein export from nucleus (GO:0006611)2.27565754
183positive regulation of protein export from nucleus (GO:0046827)2.24951994
184embryo implantation (GO:0007566)2.24535310
185paraxial mesoderm development (GO:0048339)2.22970295
186negative regulation of necroptotic process (GO:0060546)2.22684728
187cellular response to unfolded protein (GO:0034620)2.22152226
188semaphorin-plexin signaling pathway (GO:0071526)2.22144999
189peptidyl-proline hydroxylation (GO:0019511)2.20985334
190protein localization to microtubule (GO:0035372)2.20970021
191endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.19837419
192endocytic recycling (GO:0032456)2.19637783
193negative regulation of DNA repair (GO:0045738)2.19191929
194cellular hyperosmotic response (GO:0071474)2.18919191
195peptidyl-lysine dimethylation (GO:0018027)2.18749424
196insulin-like growth factor receptor signaling pathway (GO:0048009)2.17899392
197low-density lipoprotein particle clearance (GO:0034383)2.16700869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.14999396
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47820816
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.13272821
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.87271639
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.71017399
6ZNF263_19887448_ChIP-Seq_K562_Human3.47932269
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.40684483
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.34332297
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.00652327
10CLOCK_20551151_ChIP-Seq_293T_Human2.76574441
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.51686065
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.44044672
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43967472
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35108594
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34760061
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20386442
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08629290
18AR_21909140_ChIP-Seq_LNCAP_Human1.95702893
19LXR_22292898_ChIP-Seq_THP-1_Human1.95112454
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85496455
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80045367
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.75464440
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70297285
24MYC_22102868_ChIP-Seq_BL_Human1.66533989
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65469452
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64402097
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60078333
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58480035
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55135983
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54433410
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53309404
32TCF7_22412390_ChIP-Seq_EML_Mouse1.51030859
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49946130
34ATF3_27146783_Chip-Seq_COLON_Human1.49329660
35GATA6_25053715_ChIP-Seq_YYC3_Human1.49213965
36FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.48923030
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.48337372
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.48337372
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46730123
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.44882752
41* FOXA2_19822575_ChIP-Seq_HepG2_Human1.44156491
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43515928
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42736715
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41951823
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40206183
46* ESR1_20079471_ChIP-ChIP_T-47D_Human1.40107438
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39744742
48CHD1_26751641_Chip-Seq_LNCaP_Human1.39150473
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37852436
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37435701
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36500677
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34261962
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32321736
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32008847
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30691604
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.28917311
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28087021
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26840392
59VDR_24763502_ChIP-Seq_THP-1_Human1.26659661
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25842658
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24750345
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24630546
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23909485
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23207784
65KDM2B_26808549_Chip-Seq_DND41_Human1.22795596
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.22236116
67E2F7_22180533_ChIP-Seq_HELA_Human1.20994279
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20929751
69TFEB_21752829_ChIP-Seq_HELA_Human1.20710978
70GATA4_25053715_ChIP-Seq_YYC3_Human1.19757570
71NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19412528
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19352985
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18574142
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18457497
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18420391
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17730279
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17195524
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.14591610
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14285136
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13674229
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12980425
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.12372305
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.11679540
84MAF_26560356_Chip-Seq_TH1_Human1.10526186
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09133648
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08941359
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.08027369
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07497035
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07362247
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07335500
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.07328047
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06776183
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06652532
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06587095
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06142457
96* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06035727
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.05938165
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.05715959
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05341649
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05341649
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04518434
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04474602
103* HNF4A_19822575_ChIP-Seq_HepG2_Human1.04400094
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.04363294
105NCOR1_26117541_ChIP-Seq_K562_Human1.04288990
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04218796
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04091503
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03293543
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02270125
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01092486
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00610782
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00516315
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00208113
114TET1_21451524_ChIP-Seq_MESCs_Mouse0.99845563
115CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99605919
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99099182
117RACK7_27058665_Chip-Seq_MCF-7_Human0.98280942
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.98252611
119* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98172236
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96894596
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.96632399
122MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94859782
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94721372
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94393017
125MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93915598
126CJUN_26792858_Chip-Seq_BT549_Human0.93208430
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91279200
128KDM2B_26808549_Chip-Seq_K562_Human0.90486233
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90477278
130VDR_21846776_ChIP-Seq_THP-1_Human0.90294723
131MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89979520
132* BRD4_25478319_ChIP-Seq_HGPS_Human0.88847529
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88189836
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.88188369
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87896994
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84537688
137TP53_22127205_ChIP-Seq_IMR90_Human0.84151861
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83765143
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.83579659
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80892520
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80534934
142PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80427873
143* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80146727
144* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79496671
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78939169
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78757884
147UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78525028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.05227163
2MP0002139_abnormal_hepatobiliary_system3.72244713
3MP0003705_abnormal_hypodermis_morpholog3.00419754
4MP0005365_abnormal_bile_salt2.93750422
5MP0010030_abnormal_orbit_morphology2.88311830
6MP0005085_abnormal_gallbladder_physiolo2.64890663
7MP0002102_abnormal_ear_morphology2.58171197
8MP0010234_abnormal_vibrissa_follicle2.47525150
9MP0009840_abnormal_foam_cell2.46468215
10MP0003806_abnormal_nucleotide_metabolis2.44605766
11MP0005058_abnormal_lysosome_morphology2.34071010
12MP0003252_abnormal_bile_duct2.24687888
13MP0005257_abnormal_intraocular_pressure2.24605409
14MP0005451_abnormal_body_composition2.24390125
15MP0003091_abnormal_cell_migration2.20002364
16MP0008789_abnormal_olfactory_epithelium2.12206588
17MP0010352_gastrointestinal_tract_polyps2.11624166
18MP0008875_abnormal_xenobiotic_pharmacok2.02667927
19MP0003950_abnormal_plasma_membrane1.92906832
20MP0008260_abnormal_autophagy1.90552611
21MP0005076_abnormal_cell_differentiation1.81336883
22MP0004272_abnormal_basement_membrane1.76980061
23MP0000751_myopathy1.76099533
24MP0002138_abnormal_hepatobiliary_system1.73932181
25MP0010329_abnormal_lipoprotein_level1.73407256
26MP0005408_hypopigmentation1.64755151
27MP0009053_abnormal_anal_canal1.55741286
28MP0001348_abnormal_lacrimal_gland1.55720600
29MP0010368_abnormal_lymphatic_system1.54931951
30MP0004858_abnormal_nervous_system1.53925254
31MP0005187_abnormal_penis_morphology1.49886801
32MP0003279_aneurysm1.48510686
33MP0003646_muscle_fatigue1.44832349
34MP0003453_abnormal_keratinocyte_physiol1.43755890
35MP0003303_peritoneal_inflammation1.42237080
36MP0003941_abnormal_skin_development1.41499091
37MP0002653_abnormal_ependyma_morphology1.40947078
38MP0004264_abnormal_extraembryonic_tissu1.40291516
39MP0002877_abnormal_melanocyte_morpholog1.40204532
40MP0004233_abnormal_muscle_weight1.40162359
41MP0001984_abnormal_olfaction1.39971240
42MP0000858_altered_metastatic_potential1.39763075
43MP0000747_muscle_weakness1.38395772
44MP0001666_abnormal_nutrient_absorption1.32478678
45MP0006054_spinal_hemorrhage1.32446305
46MP0000759_abnormal_skeletal_muscle1.32204278
47MP0000609_abnormal_liver_physiology1.31299753
48MP0001958_emphysema1.31194255
49MP0001849_ear_inflammation1.30096043
50MP0005499_abnormal_olfactory_system1.30064936
51MP0005394_taste/olfaction_phenotype1.30064936
52MP0001915_intracranial_hemorrhage1.29050159
53MP0004185_abnormal_adipocyte_glucose1.27569075
54MP0000537_abnormal_urethra_morphology1.27187347
55MP0005501_abnormal_skin_physiology1.26372252
56MP0005409_darkened_coat_color1.23814688
57MP0003191_abnormal_cellular_cholesterol1.23584810
58MP0003718_maternal_effect1.20207058
59MP0000767_abnormal_smooth_muscle1.19540000
60MP0005375_adipose_tissue_phenotype1.18682185
61MP0008438_abnormal_cutaneous_collagen1.15065263
62MP0004130_abnormal_muscle_cell1.14867028
63MP0005621_abnormal_cell_physiology1.14410446
64MP0001346_abnormal_lacrimal_gland1.13537246
65MP0000579_abnormal_nail_morphology1.11444724
66MP0002896_abnormal_bone_mineralization1.11334338
67MP0005023_abnormal_wound_healing1.10920129
68MP0000003_abnormal_adipose_tissue1.10762344
69MP0005083_abnormal_biliary_tract1.10357552
70MP0010630_abnormal_cardiac_muscle1.08698185
71MP0001661_extended_life_span1.07112787
72MP0000749_muscle_degeneration1.06941831
73MP0005666_abnormal_adipose_tissue1.06735780
74MP0002233_abnormal_nose_morphology1.04976980
75MP0004947_skin_inflammation1.04273595
76MP0004808_abnormal_hematopoietic_stem1.03554022
77MP0000569_abnormal_digit_pigmentation1.03521885
78MP0003111_abnormal_nucleus_morphology1.03213928
79MP0002295_abnormal_pulmonary_circulatio1.02833926
80MP0009115_abnormal_fat_cell1.02245813
81MP0002998_abnormal_bone_remodeling1.01680467
82MP0001730_embryonic_growth_arrest1.01399646
83MP0003448_altered_tumor_morphology1.01242901
84MP0003300_gastrointestinal_ulcer0.99344926
85MP0003828_pulmonary_edema0.99246294
86MP0002249_abnormal_larynx_morphology0.99148298
87MP0002089_abnormal_postnatal_growth/wei0.98976165
88MP0000566_synostosis0.98947777
89MP0006138_congestive_heart_failure0.98001245
90MP0003329_amyloid_beta_deposits0.97464275
91MP0000598_abnormal_liver_morphology0.97432786
92MP0004510_myositis0.96554170
93MP0000750_abnormal_muscle_regeneration0.96371154
94MP0004957_abnormal_blastocyst_morpholog0.96180094
95MP0003315_abnormal_perineum_morphology0.94622286
96MP0009672_abnormal_birth_weight0.94123811
97MP0004087_abnormal_muscle_fiber0.93650166
98MP0000733_abnormal_muscle_development0.93430977
99MP0005248_abnormal_Harderian_gland0.91761764
100MP0003221_abnormal_cardiomyocyte_apopto0.91649056
101MP0002166_altered_tumor_susceptibility0.91648754
102MP0005275_abnormal_skin_tensile0.90147784
103MP0009278_abnormal_bone_marrow0.89979259
104MP0003656_abnormal_erythrocyte_physiolo0.89610867
105MP0002938_white_spotting0.88651080
106MP0002269_muscular_atrophy0.87567071
107MP0002160_abnormal_reproductive_system0.87463434
108MP0003566_abnormal_cell_adhesion0.87190282
109MP0005319_abnormal_enzyme/_coenzyme0.87113218
110MP0005380_embryogenesis_phenotype0.86696154
111MP0001672_abnormal_embryogenesis/_devel0.86696154
112MP0010307_abnormal_tumor_latency0.86180068
113MP0003984_embryonic_growth_retardation0.85471718
114MP0002282_abnormal_trachea_morphology0.85391859
115MP0002396_abnormal_hematopoietic_system0.85329759
116MP0002118_abnormal_lipid_homeostasis0.85150982
117MP0000428_abnormal_craniofacial_morphol0.84966855
118* MP0002080_prenatal_lethality0.84275766
119MP0001293_anophthalmia0.84274535
120MP0000762_abnormal_tongue_morphology0.82801869
121MP0002132_abnormal_respiratory_system0.82414524
122MP0002088_abnormal_embryonic_growth/wei0.82198430
123MP0002098_abnormal_vibrissa_morphology0.82189682
124MP0003567_abnormal_fetal_cardiomyocyte0.82057883
125MP0003186_abnormal_redox_activity0.81469542
126MP0001697_abnormal_embryo_size0.81168115
127MP0003172_abnormal_lysosome_physiology0.80979345
128MP0002932_abnormal_joint_morphology0.79850368
129MP0000377_abnormal_hair_follicle0.79546636
130MP0000604_amyloidosis0.79487276
131MP0005330_cardiomyopathy0.78983351
132MP0001216_abnormal_epidermal_layer0.78954186
133MP0005384_cellular_phenotype0.78721001
134MP0002086_abnormal_extraembryonic_tissu0.78105767
135MP0005332_abnormal_amino_acid0.77761997
136MP0002796_impaired_skin_barrier0.77150985
137MP0004036_abnormal_muscle_relaxation0.77036705
138MP0002128_abnormal_blood_circulation0.77016341
139MP0002060_abnormal_skin_morphology0.77015113
140MP0003693_abnormal_embryo_hatching0.75920285
141MP0001545_abnormal_hematopoietic_system0.75492360
142MP0005397_hematopoietic_system_phenotyp0.75492360
143MP0003077_abnormal_cell_cycle0.74721870
144MP0010678_abnormal_skin_adnexa0.72997561
145MP0000490_abnormal_crypts_of0.72749015
146MP0005165_increased_susceptibility_to0.72693852
147MP0000343_altered_response_to0.72358492
148MP0009384_cardiac_valve_regurgitation0.71865145
149MP0001243_abnormal_dermal_layer0.71585512
150MP0008961_abnormal_basal_metabolism0.70641959
151MP0001299_abnormal_eye_distance/0.70577224
152MP0005623_abnormal_meninges_morphology0.70301002
153MP0005464_abnormal_platelet_physiology0.69872874
154MP0001853_heart_inflammation0.69720963
155MP0000350_abnormal_cell_proliferation0.69655685
156MP0000678_abnormal_parathyroid_gland0.69591873
157MP0002092_abnormal_eye_morphology0.68500712
158MP0008007_abnormal_cellular_replicative0.68343625
159MP0005395_other_phenotype0.68261146
160MP0005503_abnormal_tendon_morphology0.67984254

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.58863904
2Premature rupture of membranes (HP:0001788)4.05717092
3Cortical dysplasia (HP:0002539)3.83052576
4Renovascular hypertension (HP:0100817)3.50917687
5Hallux valgus (HP:0001822)3.48121285
6Deviation of the hallux (HP:0010051)3.38584009
7Lip pit (HP:0100267)3.33392618
8Hyperacusis (HP:0010780)3.25566115
9Vertebral compression fractures (HP:0002953)3.18927922
10Hypobetalipoproteinemia (HP:0003563)3.15915647
11Increased connective tissue (HP:0009025)3.10497789
12Short 4th metacarpal (HP:0010044)3.09429210
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09429210
14Xanthomatosis (HP:0000991)3.02895975
15Hyperglycinemia (HP:0002154)3.01424097
16Overriding aorta (HP:0002623)3.00513386
17Distal lower limb amyotrophy (HP:0008944)2.99640738
18Elfin facies (HP:0004428)2.98339166
19Distal lower limb muscle weakness (HP:0009053)2.96681520
20Abnormality of monocarboxylic acid metabolism (HP:0010996)2.95048214
21Centrally nucleated skeletal muscle fibers (HP:0003687)2.94157590
22Spinal rigidity (HP:0003306)2.86964770
23Hypoplastic labia majora (HP:0000059)2.86825827
24Peritonitis (HP:0002586)2.84202409
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.72936716
26Osteolytic defects of the hand bones (HP:0009699)2.72936716
27Esophageal varix (HP:0002040)2.68387190
28Abnormality of the diencephalon (HP:0010662)2.67946765
29Abnormality of the labia majora (HP:0012881)2.67501619
30Abnormality of skeletal muscle fiber size (HP:0012084)2.66722551
31Hyperammonemia (HP:0001987)2.66094397
32Achilles tendon contracture (HP:0001771)2.66025575
33Abnormality of glycine metabolism (HP:0010895)2.65434299
34Abnormality of serine family amino acid metabolism (HP:0010894)2.65434299
35Abnormality of the 4th metacarpal (HP:0010012)2.62500690
36Hyperglycinuria (HP:0003108)2.62456338
37Hyperlipoproteinemia (HP:0010980)2.60482580
38Type 1 muscle fiber predominance (HP:0003803)2.58242076
39Insomnia (HP:0100785)2.57738271
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56350764
41Increased variability in muscle fiber diameter (HP:0003557)2.56034368
42Epidermoid cyst (HP:0200040)2.53506895
43Renal duplication (HP:0000075)2.52507408
44Hypolipoproteinemia (HP:0010981)2.51563080
45Protrusio acetabuli (HP:0003179)2.51059802
46Bladder diverticulum (HP:0000015)2.50721478
47Microglossia (HP:0000171)2.47687813
48Papillary thyroid carcinoma (HP:0002895)2.45358591
49Mitral valve prolapse (HP:0001634)2.43468791
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41332003
51Complement deficiency (HP:0004431)2.40353956
52Short nail (HP:0001799)2.38424518
53Ankle contracture (HP:0006466)2.38082221
54Aortic aneurysm (HP:0004942)2.36624851
55Spinal cord lesions (HP:0100561)2.35514965
56Syringomyelia (HP:0003396)2.35514965
57Natal tooth (HP:0000695)2.34806966
58Lower limb amyotrophy (HP:0007210)2.34752128
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31344473
60Polycythemia (HP:0001901)2.31124830
61Myocardial infarction (HP:0001658)2.30833310
62Nemaline bodies (HP:0003798)2.29077283
63Vascular tortuosity (HP:0004948)2.26766200
64Hypoalphalipoproteinemia (HP:0003233)2.25714324
65Atrophic scars (HP:0001075)2.25220197
66Camptodactyly of toe (HP:0001836)2.25043990
67Fragile skin (HP:0001030)2.24294382
68Exercise-induced myalgia (HP:0003738)2.21455703
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.20819992
70Arterial tortuosity (HP:0005116)2.20784359
71Wormian bones (HP:0002645)2.20365435
72Cervical subluxation (HP:0003308)2.20227193
73Abnormality of liposaccharide metabolism (HP:0010968)2.19172121
74Abnormality of glycosphingolipid metabolism (HP:0004343)2.19172121
75Abnormality of glycolipid metabolism (HP:0010969)2.19172121
76Abnormality of the fingertips (HP:0001211)2.19171434
77Shallow orbits (HP:0000586)2.18302553
78Enlarged penis (HP:0000040)2.18238804
79Bowel diverticulosis (HP:0005222)2.15910853
80Malnutrition (HP:0004395)2.15857525
81Hepatocellular carcinoma (HP:0001402)2.11633256
82Muscle fiber inclusion bodies (HP:0100299)2.11205459
83Conjunctival hamartoma (HP:0100780)2.10990711
84Flat acetabular roof (HP:0003180)2.10586826
85Cerebral inclusion bodies (HP:0100314)2.10214119
86Abnormality of serum amino acid levels (HP:0003112)2.10048725
87Back pain (HP:0003418)2.06881859
88Distal upper limb amyotrophy (HP:0007149)2.06861058
89Upper limb amyotrophy (HP:0009129)2.06861058
90Ketosis (HP:0001946)2.05468828
91Long clavicles (HP:0000890)2.03450928
92Macroorchidism (HP:0000053)2.03142115
93Difficulty climbing stairs (HP:0003551)2.03109654
94Asymmetric septal hypertrophy (HP:0001670)2.03069147
95Advanced eruption of teeth (HP:0006288)2.03000589
96Long palpebral fissure (HP:0000637)2.00973504
97Long toe (HP:0010511)2.00910935
98Hematochezia (HP:0002573)2.00536399
99Mildly elevated creatine phosphokinase (HP:0008180)2.00527880
100Cerebral aneurysm (HP:0004944)1.99905003
101Mitral regurgitation (HP:0001653)1.99828040
102Right ventricular cardiomyopathy (HP:0011663)1.99745517
103Polygenic inheritance (HP:0010982)1.99742179
104Abnormality of the peritoneum (HP:0002585)1.99505418
105Intrahepatic cholestasis (HP:0001406)1.99263843
106Dilatation of the ascending aorta (HP:0005111)1.98070310
107Blue sclerae (HP:0000592)1.97912862
108Elbow flexion contracture (HP:0002987)1.94119111
109Chondrocalcinosis (HP:0000934)1.93430627
110Thin bony cortex (HP:0002753)1.92769064
111Broad face (HP:0000283)1.92074175
112Aortic dissection (HP:0002647)1.92032251
113Ulnar bowing (HP:0003031)1.91768857
114Acanthocytosis (HP:0001927)1.90888092
115Insidious onset (HP:0003587)1.90651366
116Termporal pattern (HP:0011008)1.90651366
117Hypercholesterolemia (HP:0003124)1.90494184
118Abnormality of the Achilles tendon (HP:0005109)1.88489661
119Abnormality of fatty-acid metabolism (HP:0004359)1.88274900
120Abnormality of the thoracic spine (HP:0100711)1.88158662
121Disproportionate tall stature (HP:0001519)1.87962190
122Abnormality of pyrimidine metabolism (HP:0004353)1.87826879
123Generalized amyotrophy (HP:0003700)1.86123790
124Genu recurvatum (HP:0002816)1.85606148
125Chronic bronchitis (HP:0004469)1.84564476
126Facial hemangioma (HP:0000329)1.84092049
127Buphthalmos (HP:0000557)1.83489902
128Cellulitis (HP:0100658)1.83157702
129Asymmetry of the thorax (HP:0001555)1.82877536
130Upper motor neuron abnormality (HP:0002127)1.81803534
131Flat cornea (HP:0007720)1.81272245
132Ankyloglossia (HP:0010296)1.81169576
133Neurofibrillary tangles (HP:0002185)1.79678013
134Trismus (HP:0000211)1.79607461
135Increased nuchal translucency (HP:0010880)1.79196180
136Scapular winging (HP:0003691)1.78968455
137Spondylolisthesis (HP:0003302)1.77853543
138Abnormality of lateral ventricle (HP:0030047)1.77446147
139Amyloidosis (HP:0011034)1.77442111
140Neonatal death (HP:0003811)1.76068240
141Abnormality of the gastric mucosa (HP:0004295)1.75980116
142Lymphangioma (HP:0100764)1.75315043
143Persistence of primary teeth (HP:0006335)1.73875751
144Male infertility (HP:0003251)1.73543314
145Atrioventricular block (HP:0001678)1.73193484
146Abnormality of the acetabulum (HP:0003170)1.72913301
147Hypochromic microcytic anemia (HP:0004840)1.72344029
148Hyporeflexia of lower limbs (HP:0002600)1.71336835
149Abnormality of the distal phalanges of the toes (HP:0010182)1.70952811
150Abnormality of oral frenula (HP:0000190)1.70868783
151Dysmetric saccades (HP:0000641)1.70020357
152Exostoses (HP:0100777)1.69293401
153Abnormality of sulfur amino acid metabolism (HP:0004339)1.68483505
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68430894
155Abnormality of nucleobase metabolism (HP:0010932)1.68204864
156Abnormality of the line of Schwalbe (HP:0008048)1.67394683
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66435119
158Abnormality of alanine metabolism (HP:0010916)1.66435119
159Hyperalaninemia (HP:0003348)1.66435119
160Progressive muscle weakness (HP:0003323)1.66169507
161Reduced subcutaneous adipose tissue (HP:0003758)1.65796556
162Selective tooth agenesis (HP:0001592)1.65495633
163Anterior segment dysgenesis (HP:0007700)1.65353889
164Round ear (HP:0100830)1.65122401
165Spontaneous abortion (HP:0005268)1.64207943
166Hemorrhage of the eye (HP:0011885)1.63016145
167Abnormality of complement system (HP:0005339)1.62742731
168Aneurysm (HP:0002617)1.62688985
169Dysostosis multiplex (HP:0000943)1.62321959
170Nausea (HP:0002018)1.61287056
171Thoracic kyphosis (HP:0002942)1.60081084
172Spinal cord compression (HP:0002176)1.59903188
173Sacral dimple (HP:0000960)1.59600153
174Cupped ribs (HP:0000887)1.56142842
175Arnold-Chiari malformation (HP:0002308)1.54933458
176Abnormal ossification of hand bones (HP:0005921)1.54609794
177Sparse lateral eyebrow (HP:0005338)1.53716347
178Muscle stiffness (HP:0003552)1.53489017
179Hyperparathyroidism (HP:0000843)1.53019048
180Hand muscle atrophy (HP:0009130)1.50806657
181Axonal loss (HP:0003447)1.49681019
182Biconcave vertebral bodies (HP:0004586)1.49654139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.63784454
2MAP3K103.35657212
3PKN23.35157175
4PRPF4B3.21059819
5EEF2K3.14720433
6FRK2.94085211
7IRAK32.92255014
8SMG12.61848054
9NME22.27161292
10LATS12.26257061
11FGFR22.15454098
12LATS22.08986677
13EPHA32.03695685
14ACVR1B2.00857122
15FGFR41.90534479
16TAOK31.77968078
17STK38L1.74800689
18ARAF1.69337569
19KSR11.67412735
20MAP3K131.65266515
21PDK41.62989202
22PDK31.62989202
23TTN1.58115913
24LRRK21.55576068
25PTK21.41563341
26STK101.40558721
27BCKDK1.38994809
28FGFR31.37494266
29EPHB21.36959355
30DMPK1.35449152
31KSR21.30466272
32TTK1.27315757
33ERN11.26070525
34TAOK21.24677843
35STK31.24043028
36TAOK11.22695570
37RET1.22394577
38MAP2K31.20192381
39NEK91.19660430
40CDC71.18108474
41PDGFRA1.16668655
42PTK61.16003562
43PAK21.13081653
44TESK21.12737141
45ILK1.12588846
46NEK21.11118373
47NTRK11.10540635
48PDK21.10440543
49RIPK11.09071159
50EPHB11.07585036
51SIK11.07130400
52MAPKAPK31.05510112
53RAF11.04416662
54STK241.02861421
55MST1R0.99811096
56LIMK10.95369734
57PRKD30.93109869
58CDK60.92266793
59TESK10.91286274
60PAK40.89504216
61* MTOR0.87709809
62MAP3K140.86297338
63SIK30.85993777
64MET0.85906755
65CDK40.85758479
66MAP3K30.85304003
67EPHA20.82283200
68CDC42BPA0.81350484
69JAK30.81138012
70MOS0.79063552
71MAP3K60.78292300
72BRAF0.77167730
73RPS6KA40.76711354
74CDK90.76642008
75NEK10.74513129
76LMTK20.72386035
77CAMK1D0.71154252
78MELK0.70633491
79RPS6KB20.70254675
80PDGFRB0.69922673
81CSNK1A1L0.69157298
82TYK20.68267057
83PRKAA20.67127706
84MAPK110.67023376
85TYRO30.66937387
86PRKD20.66907073
87PBK0.66475334
88CAMK1G0.65943645
89TBK10.64950166
90PRKD10.64448742
91MAP3K80.62889464
92TGFBR20.62801250
93CLK10.62726686
94RPS6KA20.62636682
95TRPM70.60955127
96SCYL20.60547484
97MAP3K10.59812446
98DDR20.59187848
99FLT30.58789264
100ERBB40.58142049
101CDK70.55716401
102ERBB20.54785718
103PDPK10.54347484
104CSNK1G10.53646744
105MAP3K90.53231813
106FGFR10.53231236
107PRKAA10.53213011
108ROCK20.52683012
109MARK20.49987125
110ICK0.48632601
111IRAK20.48481111
112ABL20.48452104
113RPS6KC10.47895847
114RPS6KL10.47895847
115BMPR1B0.47601124
116DYRK20.47556600
117PIM20.47405738
118EGFR0.45932478
119MYLK0.45885920
120CHEK20.45335914
121BMX0.45323520
122PDK10.44747202
123SGK30.44206378
124IRAK40.44054514
125PLK30.43775048
126AKT20.43305383
127EIF2AK10.42364799
128RPS6KA10.42110443
129VRK10.42086282
130CDK120.42012602
131PRKG20.40845135
132NLK0.40013710
133CSNK1G30.39490438
134JAK10.39261649
135STK380.38876325
136AURKB0.37790934
137ALK0.37565317
138MAP3K110.37366733
139DYRK1B0.36004139
140MAPK120.35109197
141PAK10.34686075
142PAK30.34295585
143TGFBR10.34237295
144PRKCZ0.33579329
145DYRK30.33356710

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27864490
2Nitrogen metabolism_Homo sapiens_hsa009103.20706268
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.64229237
4Fatty acid degradation_Homo sapiens_hsa000712.59571351
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.39869777
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33144061
7Propanoate metabolism_Homo sapiens_hsa006402.16556705
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.08802980
9Arginine biosynthesis_Homo sapiens_hsa002202.05143292
10Other glycan degradation_Homo sapiens_hsa005112.01122065
11PPAR signaling pathway_Homo sapiens_hsa033201.91865538
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86850174
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81989946
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81052080
15Pyruvate metabolism_Homo sapiens_hsa006201.78794698
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76703477
17Tryptophan metabolism_Homo sapiens_hsa003801.68406841
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66534517
19Focal adhesion_Homo sapiens_hsa045101.62944907
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59252035
21Fatty acid metabolism_Homo sapiens_hsa012121.58300219
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49940233
23beta-Alanine metabolism_Homo sapiens_hsa004101.47007313
24Prion diseases_Homo sapiens_hsa050201.46567546
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45909674
26Chemical carcinogenesis_Homo sapiens_hsa052041.40958167
27Renal cell carcinoma_Homo sapiens_hsa052111.40541209
28B cell receptor signaling pathway_Homo sapiens_hsa046621.38401067
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38036217
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35202764
31Complement and coagulation cascades_Homo sapiens_hsa046101.34893522
32Pentose phosphate pathway_Homo sapiens_hsa000301.34448109
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.28248967
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.27512230
35Butanoate metabolism_Homo sapiens_hsa006501.25010956
36Selenocompound metabolism_Homo sapiens_hsa004501.24791764
37Shigellosis_Homo sapiens_hsa051311.22389824
38Adherens junction_Homo sapiens_hsa045201.21151945
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.20881513
40Endometrial cancer_Homo sapiens_hsa052131.19983308
41ECM-receptor interaction_Homo sapiens_hsa045121.17880821
42Amoebiasis_Homo sapiens_hsa051461.17508848
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17314544
44VEGF signaling pathway_Homo sapiens_hsa043701.16187867
45Non-small cell lung cancer_Homo sapiens_hsa052231.15638724
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14975928
47Bile secretion_Homo sapiens_hsa049761.14041980
48ErbB signaling pathway_Homo sapiens_hsa040121.12150887
49Pancreatic cancer_Homo sapiens_hsa052121.10578875
50Lysosome_Homo sapiens_hsa041421.08706453
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07263477
52Dilated cardiomyopathy_Homo sapiens_hsa054141.06048395
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05960184
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.05900523
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04837302
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03701461
57Viral myocarditis_Homo sapiens_hsa054161.03240144
58Caffeine metabolism_Homo sapiens_hsa002321.02775506
59Carbon metabolism_Homo sapiens_hsa012001.02560538
60Hepatitis B_Homo sapiens_hsa051611.02260781
61Insulin resistance_Homo sapiens_hsa049311.01836237
62Apoptosis_Homo sapiens_hsa042101.01418568
63Notch signaling pathway_Homo sapiens_hsa043300.99939914
64Galactose metabolism_Homo sapiens_hsa000520.99502792
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.99155488
66Peroxisome_Homo sapiens_hsa041460.98891743
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93166515
68Fat digestion and absorption_Homo sapiens_hsa049750.93115075
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92531862
70Lysine degradation_Homo sapiens_hsa003100.92037988
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91627269
72Hepatitis C_Homo sapiens_hsa051600.91542186
73Biosynthesis of amino acids_Homo sapiens_hsa012300.91197575
74Chronic myeloid leukemia_Homo sapiens_hsa052200.91195353
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90481550
76MicroRNAs in cancer_Homo sapiens_hsa052060.90386350
77Histidine metabolism_Homo sapiens_hsa003400.89864971
78Osteoclast differentiation_Homo sapiens_hsa043800.89310956
79Retinol metabolism_Homo sapiens_hsa008300.87577316
80Endocytosis_Homo sapiens_hsa041440.86433070
81Influenza A_Homo sapiens_hsa051640.85537441
82HTLV-I infection_Homo sapiens_hsa051660.85489234
83Dorso-ventral axis formation_Homo sapiens_hsa043200.85093549
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.84333011
85Cell cycle_Homo sapiens_hsa041100.83117732
86Starch and sucrose metabolism_Homo sapiens_hsa005000.82918789
87GnRH signaling pathway_Homo sapiens_hsa049120.82892689
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82865626
89Small cell lung cancer_Homo sapiens_hsa052220.82865572
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.82399551
91One carbon pool by folate_Homo sapiens_hsa006700.79920996
92Salmonella infection_Homo sapiens_hsa051320.79893813
93Estrogen signaling pathway_Homo sapiens_hsa049150.79188143
94TNF signaling pathway_Homo sapiens_hsa046680.78891433
95Vibrio cholerae infection_Homo sapiens_hsa051100.78590181
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76810760
97Phenylalanine metabolism_Homo sapiens_hsa003600.75764912
98Insulin signaling pathway_Homo sapiens_hsa049100.75551179
99Tyrosine metabolism_Homo sapiens_hsa003500.74933983
100Melanoma_Homo sapiens_hsa052180.74270926
101Fatty acid biosynthesis_Homo sapiens_hsa000610.74235773
102mTOR signaling pathway_Homo sapiens_hsa041500.74141434
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73927723
104Colorectal cancer_Homo sapiens_hsa052100.73083028
105Fructose and mannose metabolism_Homo sapiens_hsa000510.73010601
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71545066
107Glucagon signaling pathway_Homo sapiens_hsa049220.71160027
108AMPK signaling pathway_Homo sapiens_hsa041520.70455678
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69864340
110Inositol phosphate metabolism_Homo sapiens_hsa005620.69551334
111HIF-1 signaling pathway_Homo sapiens_hsa040660.69092118
112Toxoplasmosis_Homo sapiens_hsa051450.67542001
113Prolactin signaling pathway_Homo sapiens_hsa049170.67419969
114DNA replication_Homo sapiens_hsa030300.66940559
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.66823033
116Leishmaniasis_Homo sapiens_hsa051400.66010189
117Proteoglycans in cancer_Homo sapiens_hsa052050.65951739
118TGF-beta signaling pathway_Homo sapiens_hsa043500.65644955
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65234585
120Glioma_Homo sapiens_hsa052140.64922580
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64694214
122Pathways in cancer_Homo sapiens_hsa052000.64669184
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64493437
124Glycerolipid metabolism_Homo sapiens_hsa005610.61688357
125Thyroid cancer_Homo sapiens_hsa052160.61630326
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61382202
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60861702
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.60740681
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.60697981
130p53 signaling pathway_Homo sapiens_hsa041150.60635797
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59866332
132Olfactory transduction_Homo sapiens_hsa047400.59759793
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58061479
134Measles_Homo sapiens_hsa051620.57459609
135Choline metabolism in cancer_Homo sapiens_hsa052310.56899155
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56644544
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56156512
138Hippo signaling pathway_Homo sapiens_hsa043900.55291507
139Glutathione metabolism_Homo sapiens_hsa004800.55261556
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55249513
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55017399
142Tuberculosis_Homo sapiens_hsa051520.54647615
143Epstein-Barr virus infection_Homo sapiens_hsa051690.54262584
144Gap junction_Homo sapiens_hsa045400.54101219
145Sulfur relay system_Homo sapiens_hsa041220.52292078
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52038512
147Sulfur metabolism_Homo sapiens_hsa009200.51949359
148FoxO signaling pathway_Homo sapiens_hsa040680.51765253
149Renin-angiotensin system_Homo sapiens_hsa046140.50891909
150Tight junction_Homo sapiens_hsa045300.50127600
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49159375
152Bladder cancer_Homo sapiens_hsa052190.48741462
153RNA degradation_Homo sapiens_hsa030180.48337466
154Prostate cancer_Homo sapiens_hsa052150.47250270
155ABC transporters_Homo sapiens_hsa020100.47146195
156Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46015793
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.45771040
158Viral carcinogenesis_Homo sapiens_hsa052030.44671539
159Oocyte meiosis_Homo sapiens_hsa041140.44582541
160Acute myeloid leukemia_Homo sapiens_hsa052210.44536309
161Ovarian steroidogenesis_Homo sapiens_hsa049130.44199773

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