MAPKAPK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.61109473
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.61109473
3ribosomal small subunit assembly (GO:0000028)4.58985660
4negative regulation of erythrocyte differentiation (GO:0045647)4.43755674
5antigen processing and presentation of endogenous antigen (GO:0019883)4.18527547
6cellular extravasation (GO:0045123)4.15709853
7positive regulation by symbiont of host defense response (GO:0052509)4.10728496
8modulation by symbiont of host defense response (GO:0052031)4.10728496
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.10728496
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.10728496
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.10728496
12modulation by symbiont of host immune response (GO:0052553)4.10728496
13negative regulation of cell killing (GO:0031342)4.04257417
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04257417
15detection of other organism (GO:0098543)4.04251491
16detection of bacterium (GO:0016045)3.93787876
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87249630
18positive regulation of gamma-delta T cell activation (GO:0046645)3.78285242
19viral transcription (GO:0019083)3.77188491
20regulation of mast cell degranulation (GO:0043304)3.63316847
21translational termination (GO:0006415)3.62302205
22regulation of myeloid leukocyte mediated immunity (GO:0002886)3.53775072
23regulation of leukocyte degranulation (GO:0043300)3.50934869
24muscle filament sliding (GO:0030049)3.42340609
25actin-myosin filament sliding (GO:0033275)3.42340609
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.38068234
27NIK/NF-kappaB signaling (GO:0038061)3.33419393
28negative regulation of phagocytosis (GO:0050765)3.32094824
29* pinocytosis (GO:0006907)3.28190351
30macrophage activation involved in immune response (GO:0002281)3.25466914
31leukocyte aggregation (GO:0070486)3.24435918
32regulation of mast cell activation involved in immune response (GO:0033006)3.22273307
33translational elongation (GO:0006414)3.18848877
34detection of external biotic stimulus (GO:0098581)3.18152182
35antigen processing and presentation via MHC class Ib (GO:0002475)3.17554512
36myeloid dendritic cell activation (GO:0001773)3.16404615
37neutrophil activation involved in immune response (GO:0002283)3.15822827
38maturation of SSU-rRNA (GO:0030490)3.13622760
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13351783
40immunoglobulin mediated immune response (GO:0016064)3.12923008
41positive regulation of B cell differentiation (GO:0045579)3.10269109
42cellular response to zinc ion (GO:0071294)3.09040875
43ribosomal small subunit biogenesis (GO:0042274)3.05771207
44neutrophil mediated immunity (GO:0002446)3.05584023
45response to fungus (GO:0009620)3.04498187
46protein targeting to ER (GO:0045047)3.03715353
47negative regulation of necroptotic process (GO:0060546)3.02350723
48cotranslational protein targeting to membrane (GO:0006613)3.01831296
49modulation of growth of symbiont involved in interaction with host (GO:0044144)3.01546619
50regulation of growth of symbiont in host (GO:0044126)3.01546619
51negative regulation of growth of symbiont in host (GO:0044130)3.01546619
52negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.01546619
53respiratory burst (GO:0045730)3.00937395
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99658236
55response to host immune response (GO:0052572)2.99658236
56myeloid cell activation involved in immune response (GO:0002275)2.98464493
57myeloid dendritic cell differentiation (GO:0043011)2.98300170
58response to peptidoglycan (GO:0032494)2.96631092
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94545976
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94268292
61regulation of gamma-delta T cell differentiation (GO:0045586)2.92415723
62regulation of interleukin-12 biosynthetic process (GO:0045075)2.90961650
63detection of biotic stimulus (GO:0009595)2.90124247
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89453255
65establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89381296
66response to muramyl dipeptide (GO:0032495)2.87450070
67positive regulation of mast cell activation (GO:0033005)2.86659297
68viral life cycle (GO:0019058)2.85328354
69negative regulation of T cell mediated immunity (GO:0002710)2.83942813
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83575526
71DNA deamination (GO:0045006)2.83311733
72protein localization to endoplasmic reticulum (GO:0070972)2.83220457
73translational initiation (GO:0006413)2.82484773
74response to protozoan (GO:0001562)2.81099328
75B cell mediated immunity (GO:0019724)2.81083215
76IMP metabolic process (GO:0046040)2.80809074
77response to host (GO:0075136)2.80760588
78response to host defenses (GO:0052200)2.80760588
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.80760588
80cellular hyperosmotic response (GO:0071474)2.80633440
81regulation of superoxide anion generation (GO:0032928)2.80479425
82leukocyte degranulation (GO:0043299)2.78477998
83regulation of B cell receptor signaling pathway (GO:0050855)2.77569251
84regulation of gamma-delta T cell activation (GO:0046643)2.76615775
85defense response to protozoan (GO:0042832)2.76326608
86negative regulation of leukocyte mediated immunity (GO:0002704)2.75685013
87negative regulation of interleukin-12 production (GO:0032695)2.75428294
88regulation of mast cell activation (GO:0033003)2.74330710
89IMP biosynthetic process (GO:0006188)2.73313725
90barbed-end actin filament capping (GO:0051016)2.71540711
91regulation of necrotic cell death (GO:0010939)2.71388357
92T cell apoptotic process (GO:0070231)2.71052139
93B cell receptor signaling pathway (GO:0050853)2.70345861
94germinal center formation (GO:0002467)2.70058231
95negative regulation of lymphocyte mediated immunity (GO:0002707)2.70056989
96negative thymic T cell selection (GO:0045060)2.70029865
97positive regulation of mast cell activation involved in immune response (GO:0033008)2.69957749
98positive regulation of mast cell degranulation (GO:0043306)2.69957749
99dendritic cell differentiation (GO:0097028)2.69910612
100cellular protein complex disassembly (GO:0043624)2.68196298
101regulation of regulated secretory pathway (GO:1903305)2.66100210
102regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.64717111
1033-UTR-mediated mRNA stabilization (GO:0070935)2.63451425
104detection of molecule of bacterial origin (GO:0032490)2.62580468
105response to interferon-beta (GO:0035456)2.61971751
106defense response to fungus (GO:0050832)2.61966599
107positive regulation of isotype switching (GO:0045830)2.61435923
108leukocyte mediated cytotoxicity (GO:0001909)2.61228553
109regulation of B cell differentiation (GO:0045577)2.61085737
110regulation of hypersensitivity (GO:0002883)2.58837801
111interferon-gamma production (GO:0032609)2.58815518
112heart process (GO:0003015)2.58586882
113heart contraction (GO:0060047)2.58586882
114cellular response to thyroid hormone stimulus (GO:0097067)2.58292809
115negative T cell selection (GO:0043383)2.57795218
116formation of translation preinitiation complex (GO:0001731)2.57680953
117positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57204334
118neutrophil activation (GO:0042119)2.56266440
119actin-mediated cell contraction (GO:0070252)2.53758327
120regulation of necroptotic process (GO:0060544)2.52922979
121positive regulation of natural killer cell differentiation (GO:0032825)2.52244727
122positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51585058
123negative regulation of interleukin-6 production (GO:0032715)2.50970381
124macrophage differentiation (GO:0030225)2.50605087
125regulation of tolerance induction (GO:0002643)2.49606381
126granulocyte activation (GO:0036230)2.48820274
127positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.48542851
128NADPH regeneration (GO:0006740)2.48307106
129negative regulation of innate immune response (GO:0045824)2.47980568
130macrophage activation (GO:0042116)2.47887626
131tolerance induction (GO:0002507)2.46834950
132positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.46249706
133regulation of T cell tolerance induction (GO:0002664)2.46201863
134response to type I interferon (GO:0034340)2.46090047
135JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46009262
136positive thymic T cell selection (GO:0045059)2.45753162
137cellular response to type I interferon (GO:0071357)2.44720446
138type I interferon signaling pathway (GO:0060337)2.44720446
139regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44716650
140mature B cell differentiation involved in immune response (GO:0002313)2.44008459
141regulation of interferon-beta biosynthetic process (GO:0045357)2.43777110
142T cell migration (GO:0072678)2.43551062
143definitive hemopoiesis (GO:0060216)2.42897644
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42896220
145positive regulation of antigen processing and presentation (GO:0002579)2.42871928
146actin nucleation (GO:0045010)2.42847533
147regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42482023
148positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.42393503
149cellular response to interferon-beta (GO:0035458)2.42128117
150lymphocyte apoptotic process (GO:0070227)2.41577028
151positive regulation of B cell mediated immunity (GO:0002714)2.40982521
152positive regulation of immunoglobulin mediated immune response (GO:0002891)2.40982521
153positive regulation of leukocyte degranulation (GO:0043302)2.40332618
154ribosomal large subunit biogenesis (GO:0042273)2.40107452
155pentose-phosphate shunt (GO:0006098)2.40052990
156DNA unwinding involved in DNA replication (GO:0006268)2.39980167
157thymic T cell selection (GO:0045061)2.39513705
158regulation of alpha-beta T cell proliferation (GO:0046640)2.38524375
159T cell homeostasis (GO:0043029)2.38457314
160protein complex disassembly (GO:0043241)2.38027103
161regulation of interleukin-8 biosynthetic process (GO:0045414)2.37073482
162positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.36954471
163myeloid leukocyte mediated immunity (GO:0002444)2.36440027
164mast cell activation (GO:0045576)2.35951325
165interferon-gamma-mediated signaling pathway (GO:0060333)2.35610053
166hepatocyte apoptotic process (GO:0097284)2.34817193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.51110648
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.25074124
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.10644239
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.97026175
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95204943
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83571989
7* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.72986378
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.65532988
9MYC_22102868_ChIP-Seq_BL_Human2.60982747
10VDR_21846776_ChIP-Seq_THP-1_Human2.57377616
11* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52685689
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52042076
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.41194776
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39126563
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34896411
16SCL_19346495_ChIP-Seq_HPC-7_Human2.32656445
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25903560
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.22682873
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10662299
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08685412
21* SPI1_23547873_ChIP-Seq_NB4_Human2.08440166
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05925104
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00711857
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.00691257
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96963673
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94439166
27MYB_26560356_Chip-Seq_TH2_Human1.92942693
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92771475
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90876732
30MAF_26560356_Chip-Seq_TH1_Human1.88517987
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87224011
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85079229
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.84535636
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81851308
35VDR_24763502_ChIP-Seq_THP-1_Human1.81508009
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81097180
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.78891370
38* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78391972
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73691436
40* MYB_26560356_Chip-Seq_TH1_Human1.70837661
41LXR_22292898_ChIP-Seq_THP-1_Human1.70213940
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69601554
43* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69405726
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66825379
45KDM2B_26808549_Chip-Seq_DND41_Human1.64611153
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62155004
47* UTX_26944678_Chip-Seq_JUKART_Human1.61495535
48* TCF7_22412390_ChIP-Seq_EML_Mouse1.55922884
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53665586
50* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53291138
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.50785483
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47821770
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46309433
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41382430
55* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40941150
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40888815
57VDR_23849224_ChIP-Seq_CD4+_Human1.40805892
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40086857
59* GATA1_19941827_ChIP-Seq_MEL_Mouse1.37607764
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36939989
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.36912064
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33287974
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32990531
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32727706
65XRN2_22483619_ChIP-Seq_HELA_Human1.31969233
66CIITA_25753668_ChIP-Seq_RAJI_Human1.31185796
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30653613
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29610753
69* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28014836
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.27654752
71RUNX_20019798_ChIP-Seq_JUKART_Human1.25448959
72MAF_26560356_Chip-Seq_TH2_Human1.24720268
73GATA1_22025678_ChIP-Seq_K562_Human1.24628252
74RACK7_27058665_Chip-Seq_MCF-7_Human1.23668734
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23613399
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22840424
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.22048126
78FOXP3_21729870_ChIP-Seq_TREG_Human1.21740754
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21373277
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20377039
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18941060
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18641731
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18399824
84NCOR1_26117541_ChIP-Seq_K562_Human1.17545680
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16276217
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.15699499
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15677136
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15674270
89TFEB_21752829_ChIP-Seq_HELA_Human1.15559690
90PU_27001747_Chip-Seq_BMDM_Mouse1.14213617
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14201647
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.12246422
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11827524
94BCL6_27268052_Chip-Seq_Bcells_Human1.11637535
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.11423334
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11383703
97SPI1_23127762_ChIP-Seq_K562_Human1.11129986
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10204189
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10138562
100BCOR_27268052_Chip-Seq_Bcells_Human1.10053223
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09690137
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09323240
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08748217
104* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06080261
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05424642
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05305322
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04617480
108P68_20966046_ChIP-Seq_HELA_Human1.04084323
109DCP1A_22483619_ChIP-Seq_HELA_Human1.03582526
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03146971
111ZNF263_19887448_ChIP-Seq_K562_Human1.01273050
112ELK1_19687146_ChIP-ChIP_HELA_Human1.00085111
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98358300
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98157206
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.98091593
116* GATA3_27048872_Chip-Seq_THYMUS_Human0.97742516
117SPI1_20517297_ChIP-Seq_HL60_Human0.97733730
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97593095
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.97322008
120TET1_21451524_ChIP-Seq_MESCs_Mouse0.96943502
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96840753
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95728146
123* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95636509
124* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94404769
125TTF2_22483619_ChIP-Seq_HELA_Human0.93598772
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92923147
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92703618
128GABP_19822575_ChIP-Seq_HepG2_Human0.91717613
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90254904
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88011051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.50812030
2MP0003436_decreased_susceptibility_to3.24886031
3MP0000685_abnormal_immune_system2.89343246
4MP0005451_abnormal_body_composition2.84970853
5MP0009785_altered_susceptibility_to2.82962016
6MP0002396_abnormal_hematopoietic_system2.70124313
7MP0005671_abnormal_response_to2.69934504
8MP0003303_peritoneal_inflammation2.52773716
9MP0002148_abnormal_hypersensitivity_rea2.50900898
10MP0005025_abnormal_response_to2.50502859
11MP0003763_abnormal_thymus_physiology2.49155356
12MP0005000_abnormal_immune_tolerance2.48247408
13MP0001800_abnormal_humoral_immune2.35511280
14MP0002419_abnormal_innate_immunity2.30610500
15MP0004084_abnormal_cardiac_muscle2.30378472
16MP0002452_abnormal_antigen_presenting2.22549767
17MP0005387_immune_system_phenotype2.20671073
18MP0001790_abnormal_immune_system2.20671073
19MP0005464_abnormal_platelet_physiology2.18024396
20MP0002420_abnormal_adaptive_immunity2.16757011
21MP0002723_abnormal_immune_serum2.16707347
22MP0001819_abnormal_immune_cell2.15870310
23MP0001853_heart_inflammation2.13382738
24MP0002837_dystrophic_cardiac_calcinosis2.07813072
25MP0002398_abnormal_bone_marrow2.06604005
26MP0008260_abnormal_autophagy2.06456284
27MP0002405_respiratory_system_inflammati2.06246097
28MP0001545_abnormal_hematopoietic_system2.04793934
29MP0005397_hematopoietic_system_phenotyp2.04793934
30MP0009333_abnormal_splenocyte_physiolog2.04239511
31MP0010352_gastrointestinal_tract_polyps2.02897574
32MP0004808_abnormal_hematopoietic_stem1.98242109
33MP0010155_abnormal_intestine_physiology1.97871624
34MP0002166_altered_tumor_susceptibility1.97618465
35MP0003693_abnormal_embryo_hatching1.94767124
36MP0000490_abnormal_crypts_of1.94619991
37MP0004036_abnormal_muscle_relaxation1.91267419
38MP0003806_abnormal_nucleotide_metabolis1.86403799
39MP0000465_gastrointestinal_hemorrhage1.86307752
40MP0000716_abnormal_immune_system1.85467021
41MP0005330_cardiomyopathy1.83151463
42MP0008057_abnormal_DNA_replication1.82875130
43MP0002722_abnormal_immune_system1.79552842
44MP0004947_skin_inflammation1.79259745
45MP0002006_tumorigenesis1.78658107
46MP0003300_gastrointestinal_ulcer1.78413127
47MP0003724_increased_susceptibility_to1.77558963
48MP0000751_myopathy1.77527260
49MP0000689_abnormal_spleen_morphology1.72798134
50MP0001873_stomach_inflammation1.69981078
51MP0002429_abnormal_blood_cell1.65330375
52MP0001845_abnormal_inflammatory_respons1.61411804
53MP0000858_altered_metastatic_potential1.59397857
54MP0006082_CNS_inflammation1.53231382
55MP0003866_abnormal_defecation1.53088365
56MP0003646_muscle_fatigue1.52752207
57MP0009278_abnormal_bone_marrow1.50994706
58MP0000749_muscle_degeneration1.44971024
59MP0000703_abnormal_thymus_morphology1.44398602
60MP0004185_abnormal_adipocyte_glucose1.44092372
61MP0001533_abnormal_skeleton_physiology1.40887889
62MP0005174_abnormal_tail_pigmentation1.39494254
63MP0010094_abnormal_chromosome_stability1.39358452
64MP0004087_abnormal_muscle_fiber1.34163589
65MP0003077_abnormal_cell_cycle1.32951717
66MP0010307_abnormal_tumor_latency1.32934572
67MP0004957_abnormal_blastocyst_morpholog1.32931225
68MP0003656_abnormal_erythrocyte_physiolo1.30776152
69MP0003566_abnormal_cell_adhesion1.29652926
70MP0003221_abnormal_cardiomyocyte_apopto1.25687141
71MP0003448_altered_tumor_morphology1.25671588
72MP0003111_abnormal_nucleus_morphology1.24695027
73MP0000343_altered_response_to1.23021307
74MP0004510_myositis1.22790158
75MP0005075_abnormal_melanosome_morpholog1.19335479
76MP0002019_abnormal_tumor_incidence1.18364871
77MP0002998_abnormal_bone_remodeling1.18270062
78MP0005666_abnormal_adipose_tissue1.18139334
79MP0005165_increased_susceptibility_to1.18024678
80MP0010630_abnormal_cardiac_muscle1.17395806
81MP0008469_abnormal_protein_level1.15298131
82MP0003172_abnormal_lysosome_physiology1.14133291
83MP0000747_muscle_weakness1.10512681
84MP0005076_abnormal_cell_differentiation1.08856573
85MP0002972_abnormal_cardiac_muscle1.08643515
86MP0008007_abnormal_cellular_replicative1.08304329
87MP0001851_eye_inflammation1.08214131
88MP0004233_abnormal_muscle_weight1.06209061
89MP0002269_muscular_atrophy1.05778864
90MP0005058_abnormal_lysosome_morphology1.05677306
91MP0002877_abnormal_melanocyte_morpholog1.05444551
92MP0005310_abnormal_salivary_gland1.04420991
93MP0002332_abnormal_exercise_endurance1.03258377
94MP0006036_abnormal_mitochondrial_physio1.01599013
95MP0000750_abnormal_muscle_regeneration1.00582223
96MP0009840_abnormal_foam_cell0.97381997
97MP0003453_abnormal_keratinocyte_physiol0.97253527
98MP0000759_abnormal_skeletal_muscle0.97211677
99MP0008004_abnormal_stomach_pH0.97209928
100MP0003191_abnormal_cellular_cholesterol0.96059013
101MP0003183_abnormal_peptide_metabolism0.95115950
102MP0005023_abnormal_wound_healing0.94780355
103MP0005166_decreased_susceptibility_to0.94227846
104MP0009764_decreased_sensitivity_to0.92981334
105MP0004130_abnormal_muscle_cell0.92710933
106MP0001216_abnormal_epidermal_layer0.91280238
107MP0006138_congestive_heart_failure0.90470458
108MP0001849_ear_inflammation0.87346094
109MP0002132_abnormal_respiratory_system0.87262040
110MP0002933_joint_inflammation0.86891156
111MP0001544_abnormal_cardiovascular_syste0.86357818
112MP0005385_cardiovascular_system_phenoty0.86357818
113MP0008058_abnormal_DNA_repair0.85916074
114MP0002106_abnormal_muscle_physiology0.85411507
115MP0003828_pulmonary_edema0.84910793
116MP0000313_abnormal_cell_death0.84054010
117MP0000604_amyloidosis0.83596778
118MP0004484_altered_response_of0.83523239
119MP0004215_abnormal_myocardial_fiber0.82354549
120MP0002254_reproductive_system_inflammat0.82093562
121MP0002796_impaired_skin_barrier0.81594529
122MP0003705_abnormal_hypodermis_morpholog0.79662521
123MP0000350_abnormal_cell_proliferation0.77677068
124MP0009763_increased_sensitivity_to0.74960271
125MP0010234_abnormal_vibrissa_follicle0.74946130
126MP0002095_abnormal_skin_pigmentation0.74036691
127MP0009931_abnormal_skin_appearance0.72847650
128MP0006054_spinal_hemorrhage0.69726371
129MP0000477_abnormal_intestine_morphology0.69642031
130MP0000371_diluted_coat_color0.69510226
131MP0003186_abnormal_redox_activity0.68883850
132MP0005501_abnormal_skin_physiology0.68218531
133MP0001663_abnormal_digestive_system0.68089338
134MP0004782_abnormal_surfactant_physiolog0.65340449
135MP0001348_abnormal_lacrimal_gland0.64210941
136MP0003075_altered_response_to0.62482104
137MP0001191_abnormal_skin_condition0.61904745
138MP0005390_skeleton_phenotype0.59724043

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.36510063
2Elevated erythrocyte sedimentation rate (HP:0003565)5.03940506
3Thrombocytosis (HP:0001894)4.74391844
4Recurrent abscess formation (HP:0002722)4.67713394
5Myositis (HP:0100614)4.51638868
6Recurrent bacterial skin infections (HP:0005406)4.23515606
7Recurrent fungal infections (HP:0002841)3.99230455
8IgM deficiency (HP:0002850)3.75597556
9Exercise-induced myalgia (HP:0003738)3.56794041
10Chronic otitis media (HP:0000389)3.55258722
11Centrally nucleated skeletal muscle fibers (HP:0003687)3.54181038
12Petechiae (HP:0000967)3.54088180
13Orchitis (HP:0100796)3.52818170
14Mediastinal lymphadenopathy (HP:0100721)3.50374604
15Abnormality of cells of the erythroid lineage (HP:0012130)3.50334368
16Recurrent viral infections (HP:0004429)3.41812767
17Abnormal number of erythroid precursors (HP:0012131)3.38995421
18Chronic obstructive pulmonary disease (HP:0006510)3.38845752
19Obstructive lung disease (HP:0006536)3.38845752
20Distal lower limb muscle weakness (HP:0009053)3.38669382
21Ventricular tachycardia (HP:0004756)3.36283557
22Abnormality of T cell physiology (HP:0011840)3.31602398
23Sudden death (HP:0001699)3.30682401
24Ragged-red muscle fibers (HP:0003200)3.28391725
25Recurrent cutaneous fungal infections (HP:0011370)3.23203316
26Chronic mucocutaneous candidiasis (HP:0002728)3.23203316
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.22272066
28Abnormality of glycolipid metabolism (HP:0010969)3.22268012
29Abnormality of liposaccharide metabolism (HP:0010968)3.22268012
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.22268012
31Rhabdomyolysis (HP:0003201)3.17345763
32Asymmetric septal hypertrophy (HP:0001670)3.16958348
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.15700655
34Muscle fiber inclusion bodies (HP:0100299)3.15082768
35Recurrent skin infections (HP:0001581)3.14748980
36Interstitial pulmonary disease (HP:0006530)3.13103989
37Abnormality of macrophages (HP:0004311)3.06219785
38Nemaline bodies (HP:0003798)3.04378729
39Reticulocytopenia (HP:0001896)3.02472371
40Pustule (HP:0200039)3.01316808
41Recurrent gram-negative bacterial infections (HP:0005420)2.94577371
42Increased IgE level (HP:0003212)2.91680574
43Abnormality of T cells (HP:0002843)2.91594956
44Retrobulbar optic neuritis (HP:0100654)2.91352800
45Optic neuritis (HP:0100653)2.91352800
46Muscle fiber splitting (HP:0003555)2.90978297
47Meningitis (HP:0001287)2.90943271
48Vasculitis (HP:0002633)2.88924227
49Stomatitis (HP:0010280)2.88064862
50Hyporeflexia of lower limbs (HP:0002600)2.86850188
51Cellulitis (HP:0100658)2.84338851
52EMG: myopathic abnormalities (HP:0003458)2.83677176
53Chest pain (HP:0100749)2.77209470
54Increased connective tissue (HP:0009025)2.75430766
55Nasal polyposis (HP:0100582)2.74322541
56Periodontitis (HP:0000704)2.67929566
57Prolonged bleeding time (HP:0003010)2.64139484
58Epistaxis (HP:0000421)2.63825828
59Abnormality of skeletal muscle fiber size (HP:0012084)2.63576889
60Fatigue (HP:0012378)2.60123016
61Myoglobinuria (HP:0002913)2.59775398
62Hemoptysis (HP:0002105)2.59603665
63Leukocytosis (HP:0001974)2.58829432
64Panhypogammaglobulinemia (HP:0003139)2.57533989
65Pulmonary infiltrates (HP:0002113)2.56922698
66Hepatosplenomegaly (HP:0001433)2.56642862
67Recurrent bronchitis (HP:0002837)2.56161757
68Gastrointestinal inflammation (HP:0004386)2.55514078
69Amyloidosis (HP:0011034)2.55193288
70Distal lower limb amyotrophy (HP:0008944)2.52320858
71Abnormal platelet function (HP:0011869)2.51368274
72Impaired platelet aggregation (HP:0003540)2.51368274
73Abnormality of the nasal mucosa (HP:0000433)2.50672572
74Inflammation of the large intestine (HP:0002037)2.50237150
75Abnormality of the prostate (HP:0008775)2.49714211
76Autoimmune thrombocytopenia (HP:0001973)2.49541822
77Arterial thrombosis (HP:0004420)2.47915524
78Amaurosis fugax (HP:0100576)2.47585431
79Progressive muscle weakness (HP:0003323)2.43052371
80Hypergammaglobulinemia (HP:0010702)2.42490738
81Granulocytopenia (HP:0001913)2.40353658
82Pallor (HP:0000980)2.37847171
83Aplastic anemia (HP:0001915)2.37529559
84Skin ulcer (HP:0200042)2.36866277
85Gingivitis (HP:0000230)2.35291625
86Increased serum ferritin (HP:0003281)2.33158587
87Eosinophilia (HP:0001880)2.29312541
88Right ventricular cardiomyopathy (HP:0011663)2.28167623
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.27995196
90Increased variability in muscle fiber diameter (HP:0003557)2.26983215
91Abnormality of T cell number (HP:0011839)2.26128875
92Poikiloderma (HP:0001029)2.25541495
93Agnosia (HP:0010524)2.24819753
94Lymphopenia (HP:0001888)2.24118614
95Gangrene (HP:0100758)2.23831962
96Lipoatrophy (HP:0100578)2.23657452
97Dilated cardiomyopathy (HP:0001644)2.22699204
98T lymphocytopenia (HP:0005403)2.21734925
99Type 1 muscle fiber predominance (HP:0003803)2.19869274
100Gastrointestinal infarctions (HP:0005244)2.19653527
101Vacuolated lymphocytes (HP:0001922)2.19307091
102Exercise-induced muscle cramps (HP:0003710)2.19151892
103Abnormality of B cell number (HP:0010975)2.18974960
104B lymphocytopenia (HP:0010976)2.18974960
105Cheilitis (HP:0100825)2.18256210
106Urticaria (HP:0001025)2.17432950
107Neck muscle weakness (HP:0000467)2.17090360
108Loss of speech (HP:0002371)2.15909146
109IgA deficiency (HP:0002720)2.15880118
110Upper motor neuron abnormality (HP:0002127)2.15391284
111Gingival bleeding (HP:0000225)2.14382984
112Spontaneous hematomas (HP:0007420)2.13851379
113Dysostosis multiplex (HP:0000943)2.13237959
114Purpura (HP:0000979)2.11982370
115Subaortic stenosis (HP:0001682)2.11947007
116Abnormality of the left ventricular outflow tract (HP:0011103)2.11947007
117Keratoconjunctivitis sicca (HP:0001097)2.11935189
118Lymphoma (HP:0002665)2.11448369
119Acute myeloid leukemia (HP:0004808)2.10517503
120Abnormality of eosinophils (HP:0001879)2.09941955
121IgG deficiency (HP:0004315)2.08693742
122Keratoconjunctivitis (HP:0001096)2.08372037
123Osteomyelitis (HP:0002754)2.02903153
124Myopathic facies (HP:0002058)2.02751030
125Bulbar palsy (HP:0001283)2.01625328
126Bundle branch block (HP:0011710)2.01094632
127Encephalitis (HP:0002383)2.00247373
128Abnormality of the pleura (HP:0002103)1.99436921
129Colitis (HP:0002583)1.97642452
130Myelodysplasia (HP:0002863)1.97528470
131Difficulty running (HP:0009046)1.96284489
132Abnormality of the endocardium (HP:0004306)1.94569942
133Muscle stiffness (HP:0003552)1.93974729
134Erythema (HP:0010783)1.89287057
135Pulmonary fibrosis (HP:0002206)1.88529730
136Agammaglobulinemia (HP:0004432)1.87842135
137Difficulty climbing stairs (HP:0003551)1.87376118
138Increased density of long bones (HP:0006392)1.86168385
139Abnormal platelet volume (HP:0011876)1.85329031
140Ventricular arrhythmia (HP:0004308)1.85295001
141Thoracic kyphosis (HP:0002942)1.85172825
142Abnormality of iron homeostasis (HP:0011031)1.84413661
143Increased IgM level (HP:0003496)1.79270987
144Restrictive lung disease (HP:0002091)1.78102322
145Leukopenia (HP:0001882)1.77288153
146Basal ganglia calcification (HP:0002135)1.77100070
147Increased neuronal autofluorescent lipopigment (HP:0002074)1.75911767
148Albinism (HP:0001022)1.75570856
149Macrocytic anemia (HP:0001972)1.75138189
150Increased cerebral lipofuscin (HP:0011813)1.74878633
151Neutropenia (HP:0001875)1.74659840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.72412236
2PRPF4B3.07220561
3PIM22.56364925
4EEF2K2.54436391
5TXK2.46656618
6JAK32.41831641
7BLK2.23807809
8TEC2.22340108
9BTK2.21336898
10IRAK42.20250964
11ZAP702.16829950
12NME22.16470217
13MAP3K142.14832351
14MAP2K32.11338536
15ERN12.10411473
16TYK21.98509877
17KIT1.94104549
18TBK11.93611721
19PKN21.88103348
20STK101.83403996
21OBSCN1.75745362
22RPS6KA41.70338073
23ITK1.64291092
24LRRK21.64124064
25SMG11.59920004
26IKBKB1.53135197
27FLT31.50639771
28TAOK31.48043528
29IKBKE1.47678705
30RPS6KB21.45253087
31SYK1.41205110
32PIM11.38592953
33TRIB31.35856111
34MAP3K61.33932901
35IRAK31.31021664
36MAP3K111.27261790
37WEE11.24998680
38HCK1.19781726
39MAP3K31.18970439
40SCYL21.18869973
41TGFBR11.17537486
42TNK21.15965763
43BCKDK1.15049442
44MAP3K11.14013205
45MAPKAPK31.11900103
46EPHB11.09330352
47MOS1.08993565
48RIPK41.08967929
49LCK1.06999133
50NEK21.05250243
51GRK61.04357691
52MAPK121.02534232
53CHUK1.02320098
54TTN1.01723555
55CDC42BPA1.01471043
56CDK121.00593506
57KSR21.00317185
58CSF1R1.00011850
59JAK10.98151606
60DYRK30.95884576
61ARAF0.95772124
62FES0.88413732
63EIF2AK30.88127274
64MAP3K80.87226471
65EIF2AK10.87224466
66TRPM70.86137415
67CDK40.85056198
68MATK0.84362771
69CDC70.83401845
70TESK20.83187335
71LYN0.83072204
72RIPK10.81675846
73DMPK0.80425593
74CSK0.80360303
75CDK60.79168524
76TGFBR20.78782124
77FGR0.76875434
78CLK10.76487104
79JAK20.76440190
80IRAK20.76200517
81ICK0.75155016
82FGFR40.75035155
83MAP3K100.74486678
84PAK40.74161824
85VRK20.72574510
86PDPK10.71617612
87CDK70.70797564
88MST40.69254131
89TSSK60.68138915
90ATR0.67185525
91TAOK10.65848461
92STK40.65670125
93PRKD20.65473832
94KDR0.65289746
95NLK0.64046431
96GRK70.63580341
97MARK30.63347346
98MAPKAPK20.62992314
99RAF10.62802433
100TESK10.62582697
101PTK60.60830691
102MARK20.60535658
103FGFR30.59863708
104PIK3CG0.59501691
105PASK0.59215187
106MAP3K130.58339115
107PDK10.57297055
108TAOK20.56215909
109STK160.56038008
110ALK0.55617129
111ABL20.54434173
112MAP3K70.54212912
113RPS6KA60.52984902
114BRSK20.52491451
115STK240.52115390
116MAP3K50.51741224
117EPHA30.50511573
118ACVR1B0.50440952
119SIK10.50112160
120AURKB0.49998177
121BUB10.49747986
122MAPK110.48778684
123HIPK20.45461626
124IRAK10.44605269
125DAPK30.44492837
126PRKD10.43834077
127RPS6KA10.43788530
128RPS6KC10.43601953
129RPS6KL10.43601953
130MAPK40.41182031
131CDK190.40832430
132NEK90.40534787
133BMX0.40224528

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.77169292
2DNA replication_Homo sapiens_hsa030302.70467811
3Leishmaniasis_Homo sapiens_hsa051402.57245778
4Primary immunodeficiency_Homo sapiens_hsa053402.28994013
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.18012828
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12639399
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09091789
8Antigen processing and presentation_Homo sapiens_hsa046122.00575304
9Measles_Homo sapiens_hsa051621.99503232
10Asthma_Homo sapiens_hsa053101.98748558
11Allograft rejection_Homo sapiens_hsa053301.94841322
12Legionellosis_Homo sapiens_hsa051341.92023262
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.82172500
14Mismatch repair_Homo sapiens_hsa034301.78892293
15Osteoclast differentiation_Homo sapiens_hsa043801.77456839
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76076749
17Graft-versus-host disease_Homo sapiens_hsa053321.72586671
18Base excision repair_Homo sapiens_hsa034101.69471197
19Herpes simplex infection_Homo sapiens_hsa051681.67617105
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67180821
21Hematopoietic cell lineage_Homo sapiens_hsa046401.59593869
22B cell receptor signaling pathway_Homo sapiens_hsa046621.54259234
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51969770
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.50652920
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48549836
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46338908
27Toxoplasmosis_Homo sapiens_hsa051451.45420896
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43335001
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40761677
30Influenza A_Homo sapiens_hsa051641.37700230
31Apoptosis_Homo sapiens_hsa042101.35079855
32Acute myeloid leukemia_Homo sapiens_hsa052211.32235865
33T cell receptor signaling pathway_Homo sapiens_hsa046601.29898161
34p53 signaling pathway_Homo sapiens_hsa041151.29381936
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28981269
36Shigellosis_Homo sapiens_hsa051311.26419510
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25461179
38Spliceosome_Homo sapiens_hsa030401.24706544
39Tuberculosis_Homo sapiens_hsa051521.24424207
40Pertussis_Homo sapiens_hsa051331.22935823
41TNF signaling pathway_Homo sapiens_hsa046681.22404258
42Dilated cardiomyopathy_Homo sapiens_hsa054141.18352411
43Homologous recombination_Homo sapiens_hsa034401.17521630
44Other glycan degradation_Homo sapiens_hsa005111.15545659
45One carbon pool by folate_Homo sapiens_hsa006701.14896119
46Carbon metabolism_Homo sapiens_hsa012001.14257903
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13789355
48Malaria_Homo sapiens_hsa051441.11753589
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11383172
50Viral myocarditis_Homo sapiens_hsa054161.09284238
51Hepatitis B_Homo sapiens_hsa051611.09061735
52RNA transport_Homo sapiens_hsa030131.08877711
53Epstein-Barr virus infection_Homo sapiens_hsa051691.07480641
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07346414
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06791896
56Pentose phosphate pathway_Homo sapiens_hsa000301.05738585
57Proteasome_Homo sapiens_hsa030501.05342770
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.04193918
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03567144
60Fructose and mannose metabolism_Homo sapiens_hsa000511.02868808
61Autoimmune thyroid disease_Homo sapiens_hsa053201.01078795
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99716662
63Salmonella infection_Homo sapiens_hsa051320.99445469
64Chronic myeloid leukemia_Homo sapiens_hsa052200.98325083
65Nucleotide excision repair_Homo sapiens_hsa034200.95682622
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94582124
67Cell cycle_Homo sapiens_hsa041100.90734381
68Type I diabetes mellitus_Homo sapiens_hsa049400.88445427
69Bladder cancer_Homo sapiens_hsa052190.88425579
70Pyrimidine metabolism_Homo sapiens_hsa002400.88393672
71Viral carcinogenesis_Homo sapiens_hsa052030.88322247
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88036792
73Chemokine signaling pathway_Homo sapiens_hsa040620.86963620
74HTLV-I infection_Homo sapiens_hsa051660.86294605
75RNA polymerase_Homo sapiens_hsa030200.86160045
76Small cell lung cancer_Homo sapiens_hsa052220.83273474
77Platelet activation_Homo sapiens_hsa046110.82021569
78* VEGF signaling pathway_Homo sapiens_hsa043700.81901908
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.81745142
80Non-homologous end-joining_Homo sapiens_hsa034500.80280449
81Biosynthesis of amino acids_Homo sapiens_hsa012300.74518172
82Hepatitis C_Homo sapiens_hsa051600.73414809
83Sulfur relay system_Homo sapiens_hsa041220.71893262
84Insulin resistance_Homo sapiens_hsa049310.71332585
85RNA degradation_Homo sapiens_hsa030180.71303826
86Lysosome_Homo sapiens_hsa041420.68927796
87Staphylococcus aureus infection_Homo sapiens_hsa051500.68435143
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68268714
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65643834
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64548616
91Thyroid cancer_Homo sapiens_hsa052160.64087063
92Fanconi anemia pathway_Homo sapiens_hsa034600.63165516
93Notch signaling pathway_Homo sapiens_hsa043300.62161830
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61922436
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.61219993
96Pancreatic cancer_Homo sapiens_hsa052120.60993137
97Insulin signaling pathway_Homo sapiens_hsa049100.60645212
98HIF-1 signaling pathway_Homo sapiens_hsa040660.60182094
99Renal cell carcinoma_Homo sapiens_hsa052110.55016672
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54344109
101Endocytosis_Homo sapiens_hsa041440.53559874
102Renin-angiotensin system_Homo sapiens_hsa046140.53038996
103Prolactin signaling pathway_Homo sapiens_hsa049170.51648372
104Rheumatoid arthritis_Homo sapiens_hsa053230.51454111
105Phagosome_Homo sapiens_hsa041450.51244505
106African trypanosomiasis_Homo sapiens_hsa051430.50589986
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50467279
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.47605963
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47601937
110Galactose metabolism_Homo sapiens_hsa000520.47394459
111Caffeine metabolism_Homo sapiens_hsa002320.45530200
112GnRH signaling pathway_Homo sapiens_hsa049120.44531015
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43956224
114Endometrial cancer_Homo sapiens_hsa052130.43925956
115Non-small cell lung cancer_Homo sapiens_hsa052230.43704334
116mTOR signaling pathway_Homo sapiens_hsa041500.42858573
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41824211
118Systemic lupus erythematosus_Homo sapiens_hsa053220.41691325
119MicroRNAs in cancer_Homo sapiens_hsa052060.41223675
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.40786068
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39588274
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.39042155
123N-Glycan biosynthesis_Homo sapiens_hsa005100.38979769
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37718787
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37429647
126Amoebiasis_Homo sapiens_hsa051460.37039076
127Cardiac muscle contraction_Homo sapiens_hsa042600.36706460

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