MAPKAPK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.15372298
2negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.19633292
3negative regulation of translation, ncRNA-mediated (GO:0040033)4.19633292
4regulation of translation, ncRNA-mediated (GO:0045974)4.19633292
5meiotic chromosome segregation (GO:0045132)3.83634396
6formation of translation preinitiation complex (GO:0001731)3.68460169
7reciprocal meiotic recombination (GO:0007131)3.51184940
8reciprocal DNA recombination (GO:0035825)3.51184940
9regulation of nuclear cell cycle DNA replication (GO:0033262)3.47867021
10mitotic metaphase plate congression (GO:0007080)3.43136098
11interkinetic nuclear migration (GO:0022027)3.38407069
12folic acid metabolic process (GO:0046655)3.37803881
13purine nucleobase biosynthetic process (GO:0009113)3.34744669
14regulation of posttranscriptional gene silencing (GO:0060147)3.31021417
15regulation of gene silencing by miRNA (GO:0060964)3.31021417
16regulation of gene silencing by RNA (GO:0060966)3.31021417
17kidney morphogenesis (GO:0060993)3.25129588
18nuclear pore organization (GO:0006999)3.22799445
19L-fucose catabolic process (GO:0042355)3.21926935
20fucose catabolic process (GO:0019317)3.21926935
21L-fucose metabolic process (GO:0042354)3.21926935
22glycine metabolic process (GO:0006544)3.21235554
23neural tube formation (GO:0001841)3.20324220
24nucleobase biosynthetic process (GO:0046112)3.19479044
25folic acid-containing compound biosynthetic process (GO:0009396)3.17202942
26kynurenine metabolic process (GO:0070189)3.16750473
27cytoplasmic mRNA processing body assembly (GO:0033962)3.15174184
28negative regulation of fatty acid biosynthetic process (GO:0045717)3.12627064
29regulation of sister chromatid cohesion (GO:0007063)3.09533727
30serine family amino acid catabolic process (GO:0009071)3.09157435
31regulation of hippo signaling (GO:0035330)3.07098227
32regulation of spindle organization (GO:0090224)3.03945875
33spinal cord motor neuron differentiation (GO:0021522)3.03244608
34regulation of pigment cell differentiation (GO:0050932)3.03116067
35positive regulation of developmental pigmentation (GO:0048087)3.02916383
36protein localization to kinetochore (GO:0034501)3.01610996
37IMP biosynthetic process (GO:0006188)3.01592476
38nuclear pore complex assembly (GO:0051292)3.01221337
39histone H3-K9 methylation (GO:0051567)2.99443054
40regulation of RNA export from nucleus (GO:0046831)2.98118901
41replication fork processing (GO:0031297)2.96487580
42snRNA transcription (GO:0009301)2.95019499
43synapsis (GO:0007129)2.91963197
44positive regulation of chromosome segregation (GO:0051984)2.91901657
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91713630
46positive regulation of mitotic sister chromatid separation (GO:1901970)2.91177853
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91177853
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91177853
49mitotic nuclear envelope disassembly (GO:0007077)2.89673121
50monoubiquitinated protein deubiquitination (GO:0035520)2.88284830
51transcription from mitochondrial promoter (GO:0006390)2.88107944
52indolalkylamine catabolic process (GO:0046218)2.84346931
53tryptophan catabolic process (GO:0006569)2.84346931
54indole-containing compound catabolic process (GO:0042436)2.84346931
55rRNA catabolic process (GO:0016075)2.82660883
56folic acid transport (GO:0015884)2.82647433
57negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.80348805
58pyrimidine nucleobase catabolic process (GO:0006208)2.80180601
59protein K11-linked deubiquitination (GO:0035871)2.80099706
60regulation of mitotic spindle organization (GO:0060236)2.78147571
61DNA replication checkpoint (GO:0000076)2.77823723
62IMP metabolic process (GO:0046040)2.76527942
63indolalkylamine metabolic process (GO:0006586)2.76447906
64regulation of translational termination (GO:0006449)2.74863533
65double-strand break repair via homologous recombination (GO:0000724)2.74712488
66mitotic chromosome condensation (GO:0007076)2.74578172
67recombinational repair (GO:0000725)2.74527074
68peristalsis (GO:0030432)2.73885508
69pre-miRNA processing (GO:0031054)2.73318658
70nuclear envelope disassembly (GO:0051081)2.70753546
71membrane disassembly (GO:0030397)2.70753546
72piRNA metabolic process (GO:0034587)2.69200671
73negative regulation of DNA-dependent DNA replication (GO:2000104)2.68075661
74protein K48-linked deubiquitination (GO:0071108)2.68037625
75neuronal action potential (GO:0019228)2.66485994
76male meiosis I (GO:0007141)2.66405569
77DNA methylation involved in gamete generation (GO:0043046)2.64490635
78DNA alkylation (GO:0006305)2.61351660
79DNA methylation (GO:0006306)2.61351660
80regulation of action potential (GO:0098900)2.60936795
81peptidyl-lysine methylation (GO:0018022)2.60295402
82hindbrain development (GO:0030902)2.60113541
83negative regulation of translational initiation (GO:0045947)2.59821645
84low-density lipoprotein particle clearance (GO:0034383)2.59695197
85regulation of cholesterol storage (GO:0010885)2.59495874
86skeletal muscle tissue regeneration (GO:0043403)2.57005250
87histone H2A monoubiquitination (GO:0035518)2.55579152
88regulation of telomere maintenance (GO:0032204)2.55568484
89head development (GO:0060322)2.55114918
90cellular response to ATP (GO:0071318)2.54684169
91cell differentiation in spinal cord (GO:0021515)2.54566962
92positive regulation of CREB transcription factor activity (GO:0032793)2.54215103
93histone H3-K4 trimethylation (GO:0080182)2.53420251
94nuclear envelope organization (GO:0006998)2.51708699
95ribosome assembly (GO:0042255)2.50513093
96histone-serine phosphorylation (GO:0035404)2.50098596
97positive regulation of lipid storage (GO:0010884)2.49980738
98lysine catabolic process (GO:0006554)2.49486644
99lysine metabolic process (GO:0006553)2.49486644
100DNA damage induced protein phosphorylation (GO:0006975)2.49282207
101positive regulation by host of viral transcription (GO:0043923)2.48976027
102sulfation (GO:0051923)2.48803403
103metaphase plate congression (GO:0051310)2.48549965
104ribosome biogenesis (GO:0042254)2.48233287
105regulation of chromatin binding (GO:0035561)2.47911045
106protein localization to chromosome, centromeric region (GO:0071459)2.47692818
107mitochondrial DNA metabolic process (GO:0032042)2.46963711
108somatic diversification of immune receptors via somatic mutation (GO:0002566)2.46295846
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.46295846
110response to pheromone (GO:0019236)2.44678759
111epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43842733
112muscle filament sliding (GO:0030049)2.43731841
113actin-myosin filament sliding (GO:0033275)2.43731841
114heterochromatin organization (GO:0070828)2.43580343
115intestinal epithelial cell development (GO:0060576)2.42538875
116nucleotide salvage (GO:0043173)2.41788490
117reflex (GO:0060004)2.41547921
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41310754
119fatty acid transmembrane transport (GO:1902001)2.41116819
120behavioral response to ethanol (GO:0048149)2.40391211
121serine family amino acid metabolic process (GO:0009069)2.40136564
122sex differentiation (GO:0007548)2.39707917
123microtubule anchoring (GO:0034453)2.38730086
124DNA methylation or demethylation (GO:0044728)2.38187061
125carnitine shuttle (GO:0006853)2.37885943
126tryptophan metabolic process (GO:0006568)2.37774776
127regulation of G0 to G1 transition (GO:0070316)2.37101257
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36646893
129histone H3-K9 modification (GO:0061647)2.36372702
130regulation of establishment of cell polarity (GO:2000114)2.36305320
131positive regulation of protein homooligomerization (GO:0032464)2.35992065
132nephron epithelium morphogenesis (GO:0072088)2.35816172
133nephron tubule morphogenesis (GO:0072078)2.35816172
134ncRNA catabolic process (GO:0034661)2.35689226
135maturation of 5.8S rRNA (GO:0000460)2.35549084
136regulation of DNA endoreduplication (GO:0032875)2.35435187
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.35403549
138gamma-aminobutyric acid transport (GO:0015812)2.34858930
139neuronal stem cell maintenance (GO:0097150)2.34038494
140positive regulation of protein import into nucleus, translocation (GO:0033160)2.33854759
141trophectodermal cell differentiation (GO:0001829)2.31453259
142regulation of centrosome duplication (GO:0010824)2.30796415
143regulation of nucleobase-containing compound transport (GO:0032239)2.30730866
144cellular ketone body metabolic process (GO:0046950)2.30606959
145cardiovascular system development (GO:0072358)2.30448333
146protein import into peroxisome matrix (GO:0016558)2.29626267
147sarcomere organization (GO:0045214)2.29023379
148pentose-phosphate shunt (GO:0006098)2.28726858
149regulation of SMAD protein import into nucleus (GO:0060390)2.27637672
150positive regulation of SMAD protein import into nucleus (GO:0060391)2.27525417
151mitochondrial RNA metabolic process (GO:0000959)2.27512301
152synaptic transmission, cholinergic (GO:0007271)2.26561215
153regulation of centrosome cycle (GO:0046605)2.26502651
154oxidative demethylation (GO:0070989)2.26181206
155gene silencing by RNA (GO:0031047)2.25821947
156protein polyglutamylation (GO:0018095)2.25607809
157regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.25485951
158nucleobase catabolic process (GO:0046113)2.25401730
159negative regulation of fatty acid metabolic process (GO:0045922)2.25268524
160purine nucleotide salvage (GO:0032261)2.25143165
161somite rostral/caudal axis specification (GO:0032525)2.24992923
1622-oxoglutarate metabolic process (GO:0006103)2.24605502
163pore complex assembly (GO:0046931)2.24338260
164skeletal muscle adaptation (GO:0043501)2.24292070
165positive regulation of triglyceride biosynthetic process (GO:0010867)2.24144956
166response to UV-C (GO:0010225)2.23592406
167tRNA modification (GO:0006400)2.23201876
168neuromuscular synaptic transmission (GO:0007274)2.23079545
169positive regulation of gene expression, epigenetic (GO:0045815)2.23072960
170UDP-N-acetylglucosamine metabolic process (GO:0006047)2.22850300
171cilium or flagellum-dependent cell motility (GO:0001539)2.22425413
172folic acid-containing compound metabolic process (GO:0006760)2.22200021
173regulation of sequestering of triglyceride (GO:0010889)2.22153966
174regulation of helicase activity (GO:0051095)2.21715710
175paraxial mesoderm development (GO:0048339)2.21601523
176positive regulation of interferon-beta production (GO:0032728)2.20938541
177RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.20900101
178homocysteine metabolic process (GO:0050667)2.19705923
179regulation of translational fidelity (GO:0006450)2.16851779
180establishment of chromosome localization (GO:0051303)2.16717026
181regulation of integrin activation (GO:0033623)2.16702075
182positive regulation of triglyceride metabolic process (GO:0090208)2.15887874
183regulation of interferon-beta production (GO:0032648)2.15854510
1844-hydroxyproline metabolic process (GO:0019471)2.15394006
185chromatin assembly (GO:0031497)2.13999937
186protein K6-linked ubiquitination (GO:0085020)2.12897226
187tetrahydrofolate metabolic process (GO:0046653)2.12397752
188mitotic G1 DNA damage checkpoint (GO:0031571)2.12373302
189histone H2A ubiquitination (GO:0033522)2.12117446
190cysteine metabolic process (GO:0006534)2.11796444
191mRNA stabilization (GO:0048255)2.10008877
192RNA stabilization (GO:0043489)2.10008877
193NADPH regeneration (GO:0006740)2.09026867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.90747244
2ZNF274_21170338_ChIP-Seq_K562_Hela4.02286828
3EZH2_22144423_ChIP-Seq_EOC_Human3.80516693
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.10027594
5VDR_22108803_ChIP-Seq_LS180_Human3.05485761
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.00395479
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.84561568
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.71596345
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.62510743
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.62409887
11GBX2_23144817_ChIP-Seq_PC3_Human2.58884078
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.58462431
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47896865
14EWS_26573619_Chip-Seq_HEK293_Human2.47387436
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35895961
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25556179
17FUS_26573619_Chip-Seq_HEK293_Human2.24675995
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.19394330
19STAT3_1855785_ChIP-Seq_MESCs_Mouse2.15720574
20ZNF263_19887448_ChIP-Seq_K562_Human2.12174043
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12085962
22TAF15_26573619_Chip-Seq_HEK293_Human2.08369277
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05354570
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02810201
25MYC_22102868_ChIP-Seq_BL_Human1.98805464
26* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98545499
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98139844
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95474004
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95436339
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94045678
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93650314
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93354917
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91765417
34IGF1R_20145208_ChIP-Seq_DFB_Human1.91137182
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90007416
36IRF1_19129219_ChIP-ChIP_H3396_Human1.89609861
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89054184
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88734921
39ER_23166858_ChIP-Seq_MCF-7_Human1.88605366
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.87260389
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.82984423
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82984423
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80522193
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.79417464
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.77889188
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.75525917
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74665721
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73600176
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72006690
50MYC_18940864_ChIP-ChIP_HL60_Human1.71879601
51AR_21909140_ChIP-Seq_LNCAP_Human1.70822317
52* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69899021
53* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68889150
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68592377
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64519971
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64485805
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64318905
58* REST_21632747_ChIP-Seq_MESCs_Mouse1.63134975
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58384682
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57597105
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54412204
62STAT3_23295773_ChIP-Seq_U87_Human1.53826841
63AR_21572438_ChIP-Seq_LNCaP_Human1.51189087
64P300_19829295_ChIP-Seq_ESCs_Human1.50803937
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48774083
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48658066
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48319290
68RNF2_27304074_Chip-Seq_NSC_Mouse1.45344805
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45123224
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.43863173
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41840575
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40270603
73TCF4_23295773_ChIP-Seq_U87_Human1.38294870
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37940035
75* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37376387
76* ETS1_20019798_ChIP-Seq_JURKAT_Human1.37348761
77KDM5A_27292631_Chip-Seq_BREAST_Human1.36264501
78TP53_22573176_ChIP-Seq_HFKS_Human1.34496127
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34423047
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33673366
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33437166
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32056850
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31165074
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30942814
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30613858
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.30580166
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.29941788
88XRN2_22483619_ChIP-Seq_HELA_Human1.29690897
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28936034
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28346699
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27923273
92TFEB_21752829_ChIP-Seq_HELA_Human1.27252282
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26087199
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25997964
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25654756
96GABP_19822575_ChIP-Seq_HepG2_Human1.25359479
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.25241132
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25177063
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23935485
100VDR_21846776_ChIP-Seq_THP-1_Human1.23906188
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23554730
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23461624
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23429103
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23111491
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22726649
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22677631
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21810762
108CLOCK_20551151_ChIP-Seq_293T_Human1.21484995
109* VDR_23849224_ChIP-Seq_CD4+_Human1.19393668
110* ATF3_27146783_Chip-Seq_COLON_Human1.18996359
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18722372
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18405165
113* DCP1A_22483619_ChIP-Seq_HELA_Human1.17370632
114* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16483272
115BCAT_22108803_ChIP-Seq_LS180_Human1.16010678
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15556293
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13471047
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.13368705
119NANOG_21062744_ChIP-ChIP_HESCs_Human1.12538744
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12298467
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11814849
122* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11337619
123* ELK3_25401928_ChIP-Seq_HUVEC_Human1.11317391
124CBP_20019798_ChIP-Seq_JUKART_Human1.11234311
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11234311
126PIAS1_25552417_ChIP-Seq_VCAP_Human1.10893298
127MAF_26560356_Chip-Seq_TH1_Human1.09386464
128KDM2B_26808549_Chip-Seq_DND41_Human1.09085303
129BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08684023
130EST1_17652178_ChIP-ChIP_JURKAT_Human1.08345566
131WDR5_24793694_ChIP-Seq_LNCAP_Human1.07863826
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07534817
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07534817
134KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07534817
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07354838
136TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07349124
137MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07071541
138TCF7_22412390_ChIP-Seq_EML_Mouse1.06982002
139JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06706060
140SMAD3_21741376_ChIP-Seq_EPCs_Human1.06464336
141SMAD4_21799915_ChIP-Seq_A2780_Human1.06443511
142DROSHA_22980978_ChIP-Seq_HELA_Human1.06314600
143CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05968208
144SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05718093
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05499095
146AR_25329375_ChIP-Seq_VCAP_Human1.05019162
147PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04838685
148ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04448536
149TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03871046
150* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03677120
151FLI1_21867929_ChIP-Seq_TH2_Mouse1.03614495
152SOX2_16153702_ChIP-ChIP_HESCs_Human1.03410908
153RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03349890
154RUNX2_22187159_ChIP-Seq_PCA_Human1.02734823
155KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02047843
156GATA3_21878914_ChIP-Seq_MCF-7_Human1.00051208
157TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99748851
158CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99498285
159SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99007944
160SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98812767
161HOXB7_26014856_ChIP-Seq_BT474_Human0.98270440
162TP53_16413492_ChIP-PET_HCT116_Human0.97836572
163SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97650700
164REST_18959480_ChIP-ChIP_MESCs_Mouse0.97457755
165OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97168966
166* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95812914
167STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94897130
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94879637
169KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94673124
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.94492044
171* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93628951
172RACK7_27058665_Chip-Seq_MCF-7_Human0.93510435
173SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92039736
174SMAD4_21741376_ChIP-Seq_EPCs_Human0.91824864
175FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91821732
176NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91655005
177NCOR1_26117541_ChIP-Seq_K562_Human0.90360878
178ERA_21632823_ChIP-Seq_H3396_Human0.90174632
179* CHD1_26751641_Chip-Seq_LNCaP_Human0.89723257
180HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89179794
181RNF2_27304074_Chip-Seq_ESCs_Mouse0.87764118
182NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87455204
183TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87122719
184FOXA1_25329375_ChIP-Seq_VCAP_Human0.87088502
185FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87088502
186EZH2_27294783_Chip-Seq_ESCs_Mouse0.86815046
187SMAD3_21741376_ChIP-Seq_ESCs_Human0.86646277
188PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86590740
189NCOR_22424771_ChIP-Seq_293T_Human0.86427587
190YY1_21170310_ChIP-Seq_MESCs_Mouse0.86183538
191KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85884238
192EED_16625203_ChIP-ChIP_MESCs_Mouse0.85255590
193TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84039675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.41162126
2MP0003806_abnormal_nucleotide_metabolis3.25279270
3MP0008877_abnormal_DNA_methylation3.10868410
4MP0003693_abnormal_embryo_hatching3.08627241
5MP0009840_abnormal_foam_cell2.85720348
6MP0003705_abnormal_hypodermis_morpholog2.76398688
7MP0003646_muscle_fatigue2.66240456
8MP0005360_urolithiasis2.52204055
9MP0005174_abnormal_tail_pigmentation2.49300956
10MP0003136_yellow_coat_color2.44134615
11MP0003787_abnormal_imprinting2.42919300
12MP0002638_abnormal_pupillary_reflex2.29865852
13MP0003111_abnormal_nucleus_morphology2.25554651
14MP0004957_abnormal_blastocyst_morpholog2.25189176
15MP0010352_gastrointestinal_tract_polyps2.22541323
16MP0004133_heterotaxia1.98133939
17MP0001188_hyperpigmentation1.96496901
18MP0004185_abnormal_adipocyte_glucose1.96126059
19MP0005076_abnormal_cell_differentiation1.88516482
20MP0010307_abnormal_tumor_latency1.88219364
21MP0006292_abnormal_olfactory_placode1.84114240
22MP0003077_abnormal_cell_cycle1.82691104
23MP0002160_abnormal_reproductive_system1.79261432
24MP0003221_abnormal_cardiomyocyte_apopto1.72795430
25MP0001730_embryonic_growth_arrest1.72774400
26MP0010094_abnormal_chromosome_stability1.72748033
27MP0002139_abnormal_hepatobiliary_system1.72685090
28MP0001986_abnormal_taste_sensitivity1.72024245
29MP0005551_abnormal_eye_electrophysiolog1.70087901
30MP0008057_abnormal_DNA_replication1.69528366
31MP0002837_dystrophic_cardiac_calcinosis1.66271915
32MP0005085_abnormal_gallbladder_physiolo1.65207590
33MP0003191_abnormal_cellular_cholesterol1.62285367
34MP0002102_abnormal_ear_morphology1.61732318
35MP0009379_abnormal_foot_pigmentation1.61677782
36MP0002938_white_spotting1.60663892
37MP0000631_abnormal_neuroendocrine_gland1.59962445
38MP0004043_abnormal_pH_regulation1.59015130
39MP0001968_abnormal_touch/_nociception1.57458856
40MP0002009_preneoplasia1.56829247
41MP0000778_abnormal_nervous_system1.55958375
42MP0001485_abnormal_pinna_reflex1.55758373
43MP0005423_abnormal_somatic_nervous1.55469779
44MP0005365_abnormal_bile_salt1.51661034
45MP0005666_abnormal_adipose_tissue1.51013688
46MP0005380_embryogenesis_phenotype1.49752025
47MP0001672_abnormal_embryogenesis/_devel1.49752025
48MP0003937_abnormal_limbs/digits/tail_de1.49088790
49MP0004742_abnormal_vestibular_system1.47218107
50MP0004130_abnormal_muscle_cell1.44790531
51MP0002269_muscular_atrophy1.44586389
52MP0004084_abnormal_cardiac_muscle1.44030744
53MP0003984_embryonic_growth_retardation1.43930206
54MP0004087_abnormal_muscle_fiber1.43487781
55MP0009745_abnormal_behavioral_response1.42372017
56MP0006072_abnormal_retinal_apoptosis1.41838896
57MP0000749_muscle_degeneration1.41665836
58MP0003828_pulmonary_edema1.40987928
59MP0002088_abnormal_embryonic_growth/wei1.40540070
60MP0000015_abnormal_ear_pigmentation1.37052149
61MP0004142_abnormal_muscle_tone1.36202945
62MP0003567_abnormal_fetal_cardiomyocyte1.36067390
63MP0009278_abnormal_bone_marrow1.35948972
64MP0000350_abnormal_cell_proliferation1.34784953
65MP0002086_abnormal_extraembryonic_tissu1.34570104
66MP0001919_abnormal_reproductive_system1.34293848
67MP0003119_abnormal_digestive_system1.30763539
68MP0005389_reproductive_system_phenotype1.29338204
69MP0003566_abnormal_cell_adhesion1.28941048
70MP0000427_abnormal_hair_cycle1.28401055
71MP0004197_abnormal_fetal_growth/weight/1.26400011
72MP0006276_abnormal_autonomic_nervous1.26140545
73MP0008995_early_reproductive_senescence1.25900072
74MP0005451_abnormal_body_composition1.25702414
75MP0005645_abnormal_hypothalamus_physiol1.25404273
76MP0002735_abnormal_chemical_nociception1.25236828
77MP0009046_muscle_twitch1.25037215
78MP0001545_abnormal_hematopoietic_system1.24452021
79MP0005397_hematopoietic_system_phenotyp1.24452021
80MP0005330_cardiomyopathy1.24345426
81MP0008961_abnormal_basal_metabolism1.23829926
82MP0003121_genomic_imprinting1.22635950
83MP0003436_decreased_susceptibility_to1.21924853
84MP0002736_abnormal_nociception_after1.21064008
85MP0000383_abnormal_hair_follicle1.20898164
86MP0001697_abnormal_embryo_size1.20387916
87MP0000609_abnormal_liver_physiology1.19174775
88MP0005253_abnormal_eye_physiology1.18976775
89MP0010630_abnormal_cardiac_muscle1.18970396
90MP0002106_abnormal_muscle_physiology1.18955468
91MP0002095_abnormal_skin_pigmentation1.17014514
92MP0002272_abnormal_nervous_system1.16926977
93MP0005386_behavior/neurological_phenoty1.14853644
94MP0004924_abnormal_behavior1.14853644
95MP0002184_abnormal_innervation1.14608652
96MP0008775_abnormal_heart_ventricle1.12389270
97MP0000747_muscle_weakness1.11178922
98MP0002751_abnormal_autonomic_nervous1.09671549
99MP0002080_prenatal_lethality1.08288765
100MP0000955_abnormal_spinal_cord1.08213119
101MP0002653_abnormal_ependyma_morphology1.07022700
102MP0002064_seizures1.06903753
103MP0002063_abnormal_learning/memory/cond1.06861969
104MP0002210_abnormal_sex_determination1.06599933
105MP0009053_abnormal_anal_canal1.05895081
106MP0002572_abnormal_emotion/affect_behav1.05852430
107MP0002067_abnormal_sensory_capabilities1.05806170
108MP0006036_abnormal_mitochondrial_physio1.05582047
109MP0005187_abnormal_penis_morphology1.05409816
110MP0002084_abnormal_developmental_patter1.04671905
111MP0002557_abnormal_social/conspecific_i1.04617619
112MP0005266_abnormal_metabolism1.04353544
113MP0003635_abnormal_synaptic_transmissio1.03497844
114MP0002332_abnormal_exercise_endurance1.02984041
115MP0003303_peritoneal_inflammation1.02954803
116MP0003252_abnormal_bile_duct1.02807416
117MP0004145_abnormal_muscle_electrophysio1.02639589
118MP0009333_abnormal_splenocyte_physiolog1.02634953
119MP0004885_abnormal_endolymph1.02182358
120MP0000750_abnormal_muscle_regeneration1.02117944
121MP0008872_abnormal_physiological_respon1.02105516
122MP0003195_calcinosis1.01874859
123MP0001293_anophthalmia1.01668432
124MP0008058_abnormal_DNA_repair1.00328590
125MP0005319_abnormal_enzyme/_coenzyme1.00148601
126MP0000733_abnormal_muscle_development0.99855384
127MP0003861_abnormal_nervous_system0.99452523
128MP0005646_abnormal_pituitary_gland0.99366142
129MP0003698_abnormal_male_reproductive0.99242095
130MP0010030_abnormal_orbit_morphology0.99219379
131MP0003656_abnormal_erythrocyte_physiolo0.98793054
132MP0003950_abnormal_plasma_membrane0.98516778
133MP0005670_abnormal_white_adipose0.98372033
134MP0003283_abnormal_digestive_organ0.96783969
135MP0002085_abnormal_embryonic_tissue0.96678932
136MP0002928_abnormal_bile_duct0.96105851
137MP0003890_abnormal_embryonic-extraembry0.94177405
138MP0001486_abnormal_startle_reflex0.93683075
139MP0000751_myopathy0.93604380
140MP0002752_abnormal_somatic_nervous0.92879183
141MP0005195_abnormal_posterior_eye0.92374156
142MP0010329_abnormal_lipoprotein_level0.91548377
143MP0000490_abnormal_crypts_of0.91301666
144MP0000759_abnormal_skeletal_muscle0.91085385
145MP0006082_CNS_inflammation0.90367773
146* MP0002019_abnormal_tumor_incidence0.90005911
147MP0003186_abnormal_redox_activity0.89924924
148MP0003718_maternal_effect0.89614329
149MP0002882_abnormal_neuron_morphology0.88169858
150MP0001324_abnormal_eye_pigmentation0.88047709
151MP0001929_abnormal_gametogenesis0.87646078
152MP0001544_abnormal_cardiovascular_syste0.87585142
153MP0005385_cardiovascular_system_phenoty0.87585142
154MP0001970_abnormal_pain_threshold0.87074759
155MP0002733_abnormal_thermal_nociception0.85307671
156MP0002152_abnormal_brain_morphology0.85059904
157MP0001529_abnormal_vocalization0.84920975
158MP0004036_abnormal_muscle_relaxation0.84470301
159MP0003786_premature_aging0.84448587
160MP0000598_abnormal_liver_morphology0.84103971
161MP0001346_abnormal_lacrimal_gland0.83480314
162MP0002877_abnormal_melanocyte_morpholog0.83467310
163MP0001915_intracranial_hemorrhage0.82844531
164MP0000566_synostosis0.82229327
165MP0002876_abnormal_thyroid_physiology0.81863856
166MP0001873_stomach_inflammation0.81809887
167MP0002734_abnormal_mechanical_nocicepti0.81239858
168MP0003878_abnormal_ear_physiology0.81201281
169MP0005377_hearing/vestibular/ear_phenot0.81201281
170MP0003315_abnormal_perineum_morphology0.81176871
171MP0000538_abnormal_urinary_bladder0.80800747
172MP0001145_abnormal_male_reproductive0.80426484
173MP0002971_abnormal_brown_adipose0.80224851
174MP0001286_abnormal_eye_development0.80126975
175MP0008932_abnormal_embryonic_tissue0.79499576
176MP0005023_abnormal_wound_healing0.78926899
177MP0001849_ear_inflammation0.77531336
178MP0000313_abnormal_cell_death0.77109356
179MP0008260_abnormal_autophagy0.76582445
180MP0003448_altered_tumor_morphology0.75391988
181MP0000685_abnormal_immune_system0.75381355
182MP0009115_abnormal_fat_cell0.75285363
183MP0005369_muscle_phenotype0.74765194
184MP0005332_abnormal_amino_acid0.74239396
185MP0005375_adipose_tissue_phenotype0.73280043
186MP0000266_abnormal_heart_morphology0.71678531
187MP0009672_abnormal_birth_weight0.71339322
188MP0000516_abnormal_urinary_system0.70901983
189MP0005367_renal/urinary_system_phenotyp0.70901983

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)4.12050314
2Muscle fiber splitting (HP:0003555)3.91250876
3Hyperglycinemia (HP:0002154)3.88851062
4Genetic anticipation (HP:0003743)3.81331100
5Hyperglycinuria (HP:0003108)3.71384181
6Pancreatic cysts (HP:0001737)3.65348771
7Rhabdomyolysis (HP:0003201)3.65177938
8Muscle fiber inclusion bodies (HP:0100299)3.55693991
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.50366052
10Type II lissencephaly (HP:0007260)3.49522911
11Cerebellar dysplasia (HP:0007033)3.44373387
12Molar tooth sign on MRI (HP:0002419)3.43227860
13Abnormality of midbrain morphology (HP:0002418)3.43227860
14Protruding tongue (HP:0010808)3.35342394
15Exercise-induced myalgia (HP:0003738)3.23219020
16Ulnar deviation of the wrist (HP:0003049)3.20730376
17Abnormality of glycine metabolism (HP:0010895)3.14969178
18Abnormality of serine family amino acid metabolism (HP:0010894)3.14969178
19Nephronophthisis (HP:0000090)3.14540627
20Nemaline bodies (HP:0003798)3.13773984
21Pancreatic fibrosis (HP:0100732)3.12547994
22Congenital stationary night blindness (HP:0007642)3.10597623
23Increased connective tissue (HP:0009025)3.10230009
24Difficulty climbing stairs (HP:0003551)3.01498788
25Hyperventilation (HP:0002883)3.01336199
26Myopathic facies (HP:0002058)2.89832950
27True hermaphroditism (HP:0010459)2.85312971
28Hypoplasia of the pons (HP:0012110)2.83370172
29Chronic hepatic failure (HP:0100626)2.82228092
30Myoglobinuria (HP:0002913)2.81417334
31Abnormality of the pons (HP:0007361)2.78083933
32Multiple enchondromatosis (HP:0005701)2.76763225
33Abnormality of the renal medulla (HP:0100957)2.73215774
34Polycythemia (HP:0001901)2.70485170
35Progressive cerebellar ataxia (HP:0002073)2.69350096
36Hyporeflexia of lower limbs (HP:0002600)2.63128442
37Difficulty running (HP:0009046)2.53728833
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.51426800
39Partial agenesis of the corpus callosum (HP:0001338)2.49913444
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48582865
41Abnormality of alanine metabolism (HP:0010916)2.48582865
42Hyperalaninemia (HP:0003348)2.48582865
43Areflexia of lower limbs (HP:0002522)2.46538861
44Lissencephaly (HP:0001339)2.44776500
45Round ear (HP:0100830)2.44608936
46Attenuation of retinal blood vessels (HP:0007843)2.43638539
47Pendular nystagmus (HP:0012043)2.42544565
48Ventricular tachycardia (HP:0004756)2.38656682
49Xanthomatosis (HP:0000991)2.37672610
50Autoimmune thrombocytopenia (HP:0001973)2.36961235
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35776624
52Cystic liver disease (HP:0006706)2.34937349
53Gaze-evoked nystagmus (HP:0000640)2.34664343
54Clumsiness (HP:0002312)2.33746053
55Hypobetalipoproteinemia (HP:0003563)2.33671496
56Broad-based gait (HP:0002136)2.33593563
57Spinal muscular atrophy (HP:0007269)2.32315947
58Abnormality of the renal cortex (HP:0011035)2.31776070
59Tubular atrophy (HP:0000092)2.30704800
60Hyperammonemia (HP:0001987)2.27750351
61Chorioretinal atrophy (HP:0000533)2.26643981
62Bilateral microphthalmos (HP:0007633)2.25354414
63Ependymoma (HP:0002888)2.23444609
64Hypolipoproteinemia (HP:0010981)2.22767678
65Absent thumb (HP:0009777)2.21612757
66Birth length less than 3rd percentile (HP:0003561)2.19201820
67Chromsome breakage (HP:0040012)2.18139267
68Hypoalphalipoproteinemia (HP:0003233)2.17632741
69Progressive inability to walk (HP:0002505)2.17340660
70Sudden death (HP:0001699)2.16721829
71Inability to walk (HP:0002540)2.16296952
72Type 1 muscle fiber predominance (HP:0003803)2.15331345
73Rib fusion (HP:0000902)2.14384418
74Decreased circulating renin level (HP:0003351)2.13007497
75Abnormality of the ileum (HP:0001549)2.11009368
76Meckel diverticulum (HP:0002245)2.10202089
77EMG: myopathic abnormalities (HP:0003458)2.10079752
78Abnormal number of erythroid precursors (HP:0012131)2.09020196
79Pelvic girdle muscle weakness (HP:0003749)2.08229202
80Abnormal cartilage morphology (HP:0002763)2.07742132
81Retinal dysplasia (HP:0007973)2.07286218
82Spastic diplegia (HP:0001264)2.06452726
83Abnormality of serum amino acid levels (HP:0003112)2.06444485
84Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05524359
85Ectopic kidney (HP:0000086)2.05218717
86Acute lymphatic leukemia (HP:0006721)2.04270848
87Abnormality of DNA repair (HP:0003254)2.04197872
88Sclerocornea (HP:0000647)2.03733038
89Asymmetric septal hypertrophy (HP:0001670)2.03179841
90Impulsivity (HP:0100710)2.02531727
91Myocardial infarction (HP:0001658)2.01835367
92Frequent falls (HP:0002359)2.01472789
93Calf muscle hypertrophy (HP:0008981)2.01362825
94Anencephaly (HP:0002323)2.00963501
95Colon cancer (HP:0003003)2.00823708
96Cortical dysplasia (HP:0002539)1.99949614
97Metaphyseal cupping (HP:0003021)1.99695201
98Duplicated collecting system (HP:0000081)1.99597077
99Degeneration of anterior horn cells (HP:0002398)1.98933501
100Abnormality of the anterior horn cell (HP:0006802)1.98933501
101Abnormality of the carotid arteries (HP:0005344)1.98137958
102Abnormality of sulfur amino acid metabolism (HP:0004339)1.97565256
103Patellar aplasia (HP:0006443)1.97253599
104Dandy-Walker malformation (HP:0001305)1.96027046
105Nausea (HP:0002018)1.95567285
106Abolished electroretinogram (ERG) (HP:0000550)1.95559141
107Muscle fibrillation (HP:0010546)1.94970784
108Abnormality of cells of the erythroid lineage (HP:0012130)1.94877542
109Hyperglycemia (HP:0003074)1.94558626
110Muscle hypertrophy of the lower extremities (HP:0008968)1.94548074
111Abnormality of lateral ventricle (HP:0030047)1.93628513
112Abnormal biliary tract physiology (HP:0012439)1.91899279
113Bile duct proliferation (HP:0001408)1.91899279
114Sloping forehead (HP:0000340)1.91889415
115Abnormality of the renal collecting system (HP:0004742)1.91821479
116Abnormality of chromosome stability (HP:0003220)1.91333773
117Aplasia/Hypoplasia of the patella (HP:0006498)1.91229598
118Global brain atrophy (HP:0002283)1.90458555
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89300497
120Clubbing of toes (HP:0100760)1.88596072
121Large for gestational age (HP:0001520)1.88195384
122Pustule (HP:0200039)1.88127671
123Highly arched eyebrow (HP:0002553)1.87743086
124Male pseudohermaphroditism (HP:0000037)1.87695450
125Abnormality of the Achilles tendon (HP:0005109)1.85829341
126Bony spicule pigmentary retinopathy (HP:0007737)1.85289510
127Intrahepatic cholestasis (HP:0001406)1.83863719
128Subaortic stenosis (HP:0001682)1.83110435
129Abnormality of the left ventricular outflow tract (HP:0011103)1.83110435
130Absent radius (HP:0003974)1.82674534
131Short thumb (HP:0009778)1.81597955
132Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80772701
133Preaxial hand polydactyly (HP:0001177)1.79534650
134Esophageal varix (HP:0002040)1.79373904
135Non-midline cleft lip (HP:0100335)1.78422952
136Congenital hepatic fibrosis (HP:0002612)1.78389711
137Breast hypoplasia (HP:0003187)1.78254071
138Gout (HP:0001997)1.77479419
139Aplasia involving forearm bones (HP:0009822)1.77115478
140Absent forearm bone (HP:0003953)1.77115478
141Achilles tendon contracture (HP:0001771)1.77025036
142Furrowed tongue (HP:0000221)1.76890632
143Polydipsia (HP:0001959)1.76611733
144Abnormal drinking behavior (HP:0030082)1.76611733
145Aplasia/Hypoplasia of the tibia (HP:0005772)1.75959499
146Reticulocytosis (HP:0001923)1.75827298
147Cutaneous melanoma (HP:0012056)1.75700387
148Distal arthrogryposis (HP:0005684)1.75562350
149Tachypnea (HP:0002789)1.74622194
150Abnormality of fatty-acid metabolism (HP:0004359)1.74306828
151Recurrent gram-negative bacterial infections (HP:0005420)1.73899186
152Febrile seizures (HP:0002373)1.73896273
153EMG: neuropathic changes (HP:0003445)1.72837641
154Right ventricular cardiomyopathy (HP:0011663)1.71874136
155Medial flaring of the eyebrow (HP:0010747)1.71616088
156Hypoplastic ischia (HP:0003175)1.71279886
157Fair hair (HP:0002286)1.71170957
158Abnormality of glutamine family amino acid metabolism (HP:0010902)1.71082790
159Ulnar bowing (HP:0003031)1.70899084
160Drooling (HP:0002307)1.70820404
161Anophthalmia (HP:0000528)1.70705643
162Facial hemangioma (HP:0000329)1.70222207
163Concave nail (HP:0001598)1.69968285
164Hand muscle atrophy (HP:0009130)1.68958642
165Lipoatrophy (HP:0100578)1.68345173
166Carpal bone hypoplasia (HP:0001498)1.68223579
167Rhabdomyosarcoma (HP:0002859)1.67487150
168Abnormality of pyrimidine metabolism (HP:0004353)1.67194588
169Deep venous thrombosis (HP:0002625)1.66827002
170Biliary tract neoplasm (HP:0100574)1.66549704
171Poor coordination (HP:0002370)1.65734118
172Delayed puberty (HP:0000823)1.65688550
173Back pain (HP:0003418)1.65364760
174Tongue fasciculations (HP:0001308)1.64553970
175Small hand (HP:0200055)1.64481999
176Abnormality of the musculature of the pelvis (HP:0001469)1.63018790
177Abnormality of the hip-girdle musculature (HP:0001445)1.63018790
178Abnormality of the labia minora (HP:0012880)1.62181703
179Urinary bladder sphincter dysfunction (HP:0002839)1.62038929
180Reticulocytopenia (HP:0001896)1.61981121
181Atrioventricular block (HP:0001678)1.61435580
182Optic nerve coloboma (HP:0000588)1.61147078
183Abnormality of the calcaneus (HP:0008364)1.60942801
184Neoplasm of the adrenal cortex (HP:0100641)1.59994799
185Progressive muscle weakness (HP:0003323)1.59794602
186Impaired smooth pursuit (HP:0007772)1.59688868
187Abnormality of the ischium (HP:0003174)1.59609444
188Pachygyria (HP:0001302)1.59572631
189Neck muscle weakness (HP:0000467)1.59466015
190Reduced subcutaneous adipose tissue (HP:0003758)1.59440078
191Abnormality of the labia majora (HP:0012881)1.57221626
192Stomach cancer (HP:0012126)1.56485394
193Eczematoid dermatitis (HP:0000976)1.56115868
194Hypercholesterolemia (HP:0003124)1.55626235
195Rectal prolapse (HP:0002035)1.55329428
196Abnormality of the astrocytes (HP:0100707)1.55139174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.38256421
2TRIB33.20049580
3TTN3.11560743
4TLK13.08605259
5BMPR1B2.91697711
6NEK22.82868380
7ZAK2.72501928
8ADRBK22.70850942
9MKNK22.68164588
10PNCK2.64583124
11WNK42.52845547
12MAP3K102.35557692
13WNK32.33260887
14MAP3K32.15096471
15CDK122.13996610
16PKN22.09208222
17LATS12.05777041
18NME22.00131209
19NEK11.98123561
20CASK1.93577834
21TNIK1.89671005
22INSRR1.86504632
23STK31.81749437
24MAP2K31.75397696
25SIK21.74636276
26MAP3K41.71059918
27STK241.65845386
28EPHA21.65796851
29BCKDK1.60781685
30STK38L1.60494388
31OBSCN1.59663151
32CDK41.59582192
33ICK1.55530228
34MKNK11.52180831
35MARK31.52091152
36DYRK31.51436908
37CAMK1G1.50556472
38TTK1.48852926
39OXSR11.46653281
40STK101.45992960
41RIPK11.44776315
42TYRO31.42529234
43BUB11.40850483
44PIM11.40694919
45WEE11.38975733
46GRK11.37698144
47PDK31.35007122
48PDK41.35007122
49CDC71.34065551
50MAP4K11.34009517
51STK391.33591866
52MAP3K111.31376004
53RPS6KA41.30138218
54PINK11.25492010
55CDK61.25082562
56ACVR1B1.24135827
57BRSK21.22973712
58CAMKK21.22771406
59CDK191.20578313
60MAPK131.20187253
61TYK21.18540060
62TAOK31.14032362
63BRD41.12953280
64LATS21.11659844
65PIM21.11595252
66PLK11.10182875
67PAK41.07308065
68MARK11.06770507
69STK41.05764124
70MAP2K71.02911873
71TGFBR11.02683647
72STK111.00608198
73BMX0.98425803
74MAP3K80.95529655
75FGFR20.95416762
76NTRK20.94487909
77AURKB0.93957242
78MAPK150.93790683
79DAPK20.91526554
80CSK0.90585791
81FGFR40.89758366
82PRKAA10.89578334
83CDK70.89246634
84MTOR0.89003471
85MAP3K50.88784881
86DMPK0.86725453
87PHKG10.86648058
88PHKG20.86648058
89PLK40.86568318
90SGK20.84407378
91CHUK0.83842546
92CHEK20.82767583
93ADRBK10.81553857
94PTK60.79095429
95PDK20.78449024
96TAF10.77999624
97TBK10.77879611
98CAMKK10.77762496
99WNK10.75649681
100CAMK1D0.74503050
101ALK0.74080016
102SGK2230.73668557
103SGK4940.73668557
104PAK30.73204542
105ERN10.73139454
106RPS6KA50.72028523
107SCYL20.70534575
108NTRK30.70373879
109MAP4K20.70139277
110MAP3K140.68754323
111PRKCG0.67026420
112CHEK10.66962642
113DYRK1B0.66714368
114FLT30.65770558
115TXK0.64748355
116NEK90.64192081
117TAOK20.63891884
118EEF2K0.63746038
119PIK3CA0.63728316
120AKT30.62938477
121NLK0.61236177
122JAK30.60455331
123DDR20.60033054
124ATM0.59870139
125RPS6KA10.59451719
126MAP2K40.58902123
127GSK3A0.58569909
128RPS6KA60.58257743
129RPS6KB20.57072235
130FGFR30.56821249
131MUSK0.53641445
132GRK60.53034848
133CDK20.52649310
134MELK0.51851919
135IRAK10.50775244
136SRPK10.50298607
137SIK10.49508576
138ATR0.48791129
139CAMK40.48722723
140ILK0.48601060
141MAP3K60.48560463
142ERBB40.48302085
143IKBKB0.48291498
144NUAK10.47890316
145PRKCI0.46910219
146PASK0.45625458
147PLK30.45122404
148CDK10.43177106
149MAPKAPK30.42746256
150MAP2K60.42735998
151GSK3B0.42408032
152SGK10.41912322
153AKT20.41742808
154CSNK1D0.41531081
155PDGFRA0.41457334
156DYRK1A0.40955485
157ABL20.40793044
158* MAPK110.40453760
159CSNK1E0.40390107
160MAP2K20.40295204
161CSNK1A1L0.39893388
162TAOK10.39853938
163ERBB20.39705674
164PRKAA20.39421395
165AURKA0.38147422
166AKT10.38109216
167CSNK1G20.37775456
168SGK30.37407039
169TRPM70.36506776
170VRK10.36373590
171DYRK20.35973404
172CAMK10.33167970
173PRKCQ0.32730028

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.82347312
2Nicotine addiction_Homo sapiens_hsa050332.73396022
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.70193052
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59102398
5Phototransduction_Homo sapiens_hsa047442.50610487
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23913058
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12900599
8Linoleic acid metabolism_Homo sapiens_hsa005912.12289461
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08929541
10Vitamin B6 metabolism_Homo sapiens_hsa007502.03114960
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01393279
12RNA transport_Homo sapiens_hsa030132.00649792
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90372425
14One carbon pool by folate_Homo sapiens_hsa006701.85874894
15Selenocompound metabolism_Homo sapiens_hsa004501.84391602
16Taste transduction_Homo sapiens_hsa047421.83108015
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78525964
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76017138
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74790571
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72856063
21Biosynthesis of amino acids_Homo sapiens_hsa012301.64833535
22Arginine biosynthesis_Homo sapiens_hsa002201.64627112
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.63003406
24Carbon metabolism_Homo sapiens_hsa012001.61362825
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59490476
26Fatty acid degradation_Homo sapiens_hsa000711.56274963
27RNA degradation_Homo sapiens_hsa030181.55476117
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53904138
29Butanoate metabolism_Homo sapiens_hsa006501.48681594
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46765297
31DNA replication_Homo sapiens_hsa030301.45565306
32RNA polymerase_Homo sapiens_hsa030201.45012958
33Pentose phosphate pathway_Homo sapiens_hsa000301.44128757
34Cell cycle_Homo sapiens_hsa041101.41949876
35Mismatch repair_Homo sapiens_hsa034301.38438751
36Ether lipid metabolism_Homo sapiens_hsa005651.37246553
37Base excision repair_Homo sapiens_hsa034101.36324526
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.33460878
39Folate biosynthesis_Homo sapiens_hsa007901.30937040
40Morphine addiction_Homo sapiens_hsa050321.28779463
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27198210
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25143642
43Propanoate metabolism_Homo sapiens_hsa006401.24837391
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22114682
45Glutamatergic synapse_Homo sapiens_hsa047241.20391908
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19511469
47ABC transporters_Homo sapiens_hsa020101.18529221
48p53 signaling pathway_Homo sapiens_hsa041151.18245939
49Legionellosis_Homo sapiens_hsa051341.18218543
50PPAR signaling pathway_Homo sapiens_hsa033201.17521853
51Viral myocarditis_Homo sapiens_hsa054161.17239015
52mRNA surveillance pathway_Homo sapiens_hsa030151.17089300
53Arginine and proline metabolism_Homo sapiens_hsa003301.16871440
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16162187
55Staphylococcus aureus infection_Homo sapiens_hsa051501.16082617
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.14872318
57Spliceosome_Homo sapiens_hsa030401.14485714
58Fat digestion and absorption_Homo sapiens_hsa049751.13482422
59Proteasome_Homo sapiens_hsa030501.12924875
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10756168
61Sulfur relay system_Homo sapiens_hsa041221.09782389
62Herpes simplex infection_Homo sapiens_hsa051681.09269580
63Fatty acid metabolism_Homo sapiens_hsa012121.09019450
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08603944
65Fructose and mannose metabolism_Homo sapiens_hsa000511.07731920
66Nucleotide excision repair_Homo sapiens_hsa034201.07504583
67Lysine degradation_Homo sapiens_hsa003101.06648724
68Tryptophan metabolism_Homo sapiens_hsa003801.05740194
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03140647
70Olfactory transduction_Homo sapiens_hsa047401.02890281
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01525850
72Cysteine and methionine metabolism_Homo sapiens_hsa002701.00068844
73Fatty acid biosynthesis_Homo sapiens_hsa000610.99673231
74Serotonergic synapse_Homo sapiens_hsa047260.99669268
75Cholinergic synapse_Homo sapiens_hsa047250.97704572
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96583188
77Basal cell carcinoma_Homo sapiens_hsa052170.94576118
78Starch and sucrose metabolism_Homo sapiens_hsa005000.93947842
79Dorso-ventral axis formation_Homo sapiens_hsa043200.92493228
80Circadian entrainment_Homo sapiens_hsa047130.92330921
81Hedgehog signaling pathway_Homo sapiens_hsa043400.92310907
82Calcium signaling pathway_Homo sapiens_hsa040200.91537012
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89285297
84Pyrimidine metabolism_Homo sapiens_hsa002400.88971198
85mTOR signaling pathway_Homo sapiens_hsa041500.88949975
86Insulin resistance_Homo sapiens_hsa049310.88563492
87Insulin secretion_Homo sapiens_hsa049110.86784319
88Ribosome_Homo sapiens_hsa030100.84586049
89beta-Alanine metabolism_Homo sapiens_hsa004100.84584924
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84246360
91Caffeine metabolism_Homo sapiens_hsa002320.81114634
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80033328
93Nitrogen metabolism_Homo sapiens_hsa009100.79431129
94Galactose metabolism_Homo sapiens_hsa000520.78563526
95GABAergic synapse_Homo sapiens_hsa047270.77962885
96Vitamin digestion and absorption_Homo sapiens_hsa049770.77887257
97Apoptosis_Homo sapiens_hsa042100.77559309
98Dopaminergic synapse_Homo sapiens_hsa047280.77342171
99Non-homologous end-joining_Homo sapiens_hsa034500.76489468
100Circadian rhythm_Homo sapiens_hsa047100.75659350
101Small cell lung cancer_Homo sapiens_hsa052220.75398311
102Epstein-Barr virus infection_Homo sapiens_hsa051690.74800545
103Alcoholism_Homo sapiens_hsa050340.74363376
104Long-term depression_Homo sapiens_hsa047300.73979113
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73690873
106Complement and coagulation cascades_Homo sapiens_hsa046100.73636191
107Thyroid cancer_Homo sapiens_hsa052160.71122409
108AMPK signaling pathway_Homo sapiens_hsa041520.71093390
109Peroxisome_Homo sapiens_hsa041460.70851093
110Viral carcinogenesis_Homo sapiens_hsa052030.70572576
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70490340
112Basal transcription factors_Homo sapiens_hsa030220.69480550
113Phenylalanine metabolism_Homo sapiens_hsa003600.69463137
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.69426871
115Ovarian steroidogenesis_Homo sapiens_hsa049130.69407785
116Adherens junction_Homo sapiens_hsa045200.69115518
117Cocaine addiction_Homo sapiens_hsa050300.68912865
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67854303
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.67355677
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.66575136
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64860563
122Leishmaniasis_Homo sapiens_hsa051400.63273399
123Glycerolipid metabolism_Homo sapiens_hsa005610.62731189
124Influenza A_Homo sapiens_hsa051640.62613390
125MicroRNAs in cancer_Homo sapiens_hsa052060.62609656
126Type II diabetes mellitus_Homo sapiens_hsa049300.62137422
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61684083
128Regulation of autophagy_Homo sapiens_hsa041400.59268166
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58109729
130Cardiac muscle contraction_Homo sapiens_hsa042600.57945464
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57729375
132Axon guidance_Homo sapiens_hsa043600.57410048
133Bladder cancer_Homo sapiens_hsa052190.57283360
134Measles_Homo sapiens_hsa051620.55602464
135FoxO signaling pathway_Homo sapiens_hsa040680.54688262
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53601825
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.53422742
138Glutathione metabolism_Homo sapiens_hsa004800.53217416
139Huntingtons disease_Homo sapiens_hsa050160.51873332
140Oxytocin signaling pathway_Homo sapiens_hsa049210.51751591
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.51106969
142HIF-1 signaling pathway_Homo sapiens_hsa040660.50782570
143Hippo signaling pathway_Homo sapiens_hsa043900.50464130
144Insulin signaling pathway_Homo sapiens_hsa049100.49416296
145Purine metabolism_Homo sapiens_hsa002300.48595602
146Melanoma_Homo sapiens_hsa052180.48478602
147Homologous recombination_Homo sapiens_hsa034400.48102418
148Acute myeloid leukemia_Homo sapiens_hsa052210.47867840
149Amphetamine addiction_Homo sapiens_hsa050310.47211026
150Systemic lupus erythematosus_Homo sapiens_hsa053220.46972660
151Chronic myeloid leukemia_Homo sapiens_hsa052200.46074532
152TGF-beta signaling pathway_Homo sapiens_hsa043500.46072347
153cAMP signaling pathway_Homo sapiens_hsa040240.44110903
154Hepatitis C_Homo sapiens_hsa051600.43142315
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42990565
156HTLV-I infection_Homo sapiens_hsa051660.42715515
157Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42211852
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41939046
159* MAPK signaling pathway_Homo sapiens_hsa040100.41716098
160Toxoplasmosis_Homo sapiens_hsa051450.41258635
161Pyruvate metabolism_Homo sapiens_hsa006200.40852006
162Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40665824
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40200814
164Intestinal immune network for IgA production_Homo sapiens_hsa046720.38528357
165Wnt signaling pathway_Homo sapiens_hsa043100.36542690
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.34945113
167Retinol metabolism_Homo sapiens_hsa008300.34517772
168Gastric acid secretion_Homo sapiens_hsa049710.34279695

Most similar genes based on co-expression Upload to Enrichr

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