MAPRE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.94025618
2regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.05333516
3folic acid-containing compound biosynthetic process (GO:0009396)3.99546511
4pore complex assembly (GO:0046931)3.96725242
5DNA unwinding involved in DNA replication (GO:0006268)3.85574051
6Golgi transport vesicle coating (GO:0048200)3.84004575
7COPI coating of Golgi vesicle (GO:0048205)3.84004575
8establishment of viral latency (GO:0019043)3.80004597
9CENP-A containing nucleosome assembly (GO:0034080)3.60704777
10regulation of sister chromatid cohesion (GO:0007063)3.52334016
11attachment of spindle microtubules to kinetochore (GO:0008608)3.47101873
12IMP biosynthetic process (GO:0006188)3.42403064
13double-strand break repair via nonhomologous end joining (GO:0006303)3.41547217
14non-recombinational repair (GO:0000726)3.41547217
15chromatin remodeling at centromere (GO:0031055)3.41250387
16DNA strand elongation involved in DNA replication (GO:0006271)3.38737094
17positive regulation of mitotic sister chromatid separation (GO:1901970)3.38094036
18positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38094036
19positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38094036
20mitotic chromosome condensation (GO:0007076)3.34231843
21DNA replication-independent nucleosome assembly (GO:0006336)3.32889183
22DNA replication-independent nucleosome organization (GO:0034724)3.32889183
23purine nucleobase biosynthetic process (GO:0009113)3.31494453
24mitotic metaphase plate congression (GO:0007080)3.30266060
25kinetochore organization (GO:0051383)3.26303071
26regulation of translational termination (GO:0006449)3.24801640
27protein localization to kinetochore (GO:0034501)3.22215977
28chromosome condensation (GO:0030261)3.18722804
29DNA strand elongation (GO:0022616)3.18457887
30cellular protein complex localization (GO:0034629)3.17979823
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16420846
32spindle checkpoint (GO:0031577)3.08211069
33protein complex localization (GO:0031503)3.07937557
34sister chromatid segregation (GO:0000819)3.07851745
35mitotic sister chromatid cohesion (GO:0007064)3.07737422
36pteridine-containing compound biosynthetic process (GO:0042559)3.07711303
37regulation of spindle organization (GO:0090224)3.05315287
38nucleobase-containing small molecule interconversion (GO:0015949)3.04798503
39spindle assembly involved in mitosis (GO:0090307)3.04452028
40IMP metabolic process (GO:0046040)3.02781945
41DNA replication initiation (GO:0006270)3.02479114
42deoxyribonucleotide biosynthetic process (GO:0009263)3.00105833
43metaphase plate congression (GO:0051310)2.99671475
44spindle assembly checkpoint (GO:0071173)2.99670244
45mitotic spindle checkpoint (GO:0071174)2.98069268
46regulation of translational fidelity (GO:0006450)2.97914233
47mitotic spindle assembly checkpoint (GO:0007094)2.97852263
48telomere maintenance via semi-conservative replication (GO:0032201)2.97564290
49DNA replication-dependent nucleosome organization (GO:0034723)2.97173413
50DNA replication-dependent nucleosome assembly (GO:0006335)2.97173413
51negative regulation of sister chromatid segregation (GO:0033046)2.97016667
52negative regulation of mitotic sister chromatid separation (GO:2000816)2.97016667
53negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97016667
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97016667
55mitotic recombination (GO:0006312)2.96237298
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94597008
57nucleobase biosynthetic process (GO:0046112)2.93642089
58spliceosomal tri-snRNP complex assembly (GO:0000244)2.93600616
59protein maturation by protein folding (GO:0022417)2.93528945
60histone exchange (GO:0043486)2.93023635
61mitotic sister chromatid segregation (GO:0000070)2.91481338
62negative regulation of chromosome segregation (GO:0051985)2.91323149
63mitotic nuclear envelope disassembly (GO:0007077)2.90339125
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88881099
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87252860
66DNA replication checkpoint (GO:0000076)2.87084607
67establishment of chromosome localization (GO:0051303)2.84954513
68DNA packaging (GO:0006323)2.84092387
69regulation of chromosome segregation (GO:0051983)2.82425223
70membrane disassembly (GO:0030397)2.81459397
71nuclear envelope disassembly (GO:0051081)2.81459397
72microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.81380904
73regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81299511
74telomere maintenance via recombination (GO:0000722)2.80925464
75protein localization to chromosome, centromeric region (GO:0071459)2.80735363
76DNA duplex unwinding (GO:0032508)2.80662931
77regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79786982
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78626007
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76614391
80regulation of RNA export from nucleus (GO:0046831)2.75511344
81DNA topological change (GO:0006265)2.73558696
82positive regulation of chromosome segregation (GO:0051984)2.73420774
83positive regulation of actin filament depolymerization (GO:0030836)2.72929354
84kinetochore assembly (GO:0051382)2.71445133
85negative regulation of ligase activity (GO:0051352)2.71415909
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71415909
87nuclear envelope reassembly (GO:0031468)2.70918145
88mitotic nuclear envelope reassembly (GO:0007084)2.70918145
89viral mRNA export from host cell nucleus (GO:0046784)2.70734851
90nucleotide-excision repair, DNA gap filling (GO:0006297)2.68017832
91regulation of double-strand break repair via homologous recombination (GO:0010569)2.61157027
92regulation of mitotic sister chromatid separation (GO:0010965)2.60015171
93regulation of mitotic sister chromatid segregation (GO:0033047)2.60015171
94regulation of sister chromatid segregation (GO:0033045)2.60015171
95proteasome assembly (GO:0043248)2.59568382
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57804804
97chromosome segregation (GO:0007059)2.57074465
98regulation of mitotic spindle organization (GO:0060236)2.55888663
99ATP-dependent chromatin remodeling (GO:0043044)2.50447350
100nuclear envelope organization (GO:0006998)2.45087102
101protein localization to chromosome (GO:0034502)2.44894693
102negative regulation of mitosis (GO:0045839)2.44149383
103nuclear pore organization (GO:0006999)2.44089485
104* mitotic cell cycle (GO:0000278)2.43725440
105mitotic spindle organization (GO:0007052)2.43539736
106nuclear pore complex assembly (GO:0051292)2.41655885
107G1/S transition of mitotic cell cycle (GO:0000082)2.40793908
108cell cycle G1/S phase transition (GO:0044843)2.40793908
109telomere maintenance via telomere lengthening (GO:0010833)2.39690579
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.39100441
111cullin deneddylation (GO:0010388)2.38827349
112chromatin assembly or disassembly (GO:0006333)2.38502269
113maturation of SSU-rRNA (GO:0030490)2.38291234
114DNA ligation (GO:0006266)2.37565002
115formation of translation preinitiation complex (GO:0001731)2.35416507
116regulation of telomere maintenance via telomerase (GO:0032210)2.34280531
117mitotic cytokinesis (GO:0000281)2.34220361
118protein deneddylation (GO:0000338)2.33265198
119spliceosomal snRNP assembly (GO:0000387)2.33232656
120DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.30028043
121negative regulation of RNA splicing (GO:0033119)2.29118507
122signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.26791583
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.26791583
124positive regulation of ligase activity (GO:0051351)2.26584365
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.26563035
126mRNA splicing, via spliceosome (GO:0000398)2.26563035
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.26051695
128RNA splicing, via transesterification reactions (GO:0000375)2.25862391
129protein K11-linked ubiquitination (GO:0070979)2.25424281
130regulation of ubiquitin-protein transferase activity (GO:0051438)2.24848292
131ribosome assembly (GO:0042255)2.24823492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.57400669
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.15923598
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02358637
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.50985850
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.49411429
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.02761073
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89953533
8AR_21909140_ChIP-Seq_LNCAP_Human2.72202183
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69832118
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59771368
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.53182322
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53043797
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.52658690
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42233516
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40301845
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35709689
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33669279
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27403986
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.25585842
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14892651
21XRN2_22483619_ChIP-Seq_HELA_Human2.14271723
22ELK1_19687146_ChIP-ChIP_HELA_Human2.11443029
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.02937376
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01860341
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.94749630
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93715026
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91131216
28VDR_23849224_ChIP-Seq_CD4+_Human1.82519218
29TTF2_22483619_ChIP-Seq_HELA_Human1.81364241
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.79098643
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.75830268
32DCP1A_22483619_ChIP-Seq_HELA_Human1.73193743
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69885910
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69267544
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67733179
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66819599
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61418946
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60074304
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54470790
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53578022
41GABP_19822575_ChIP-Seq_HepG2_Human1.52187315
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47506979
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45604881
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.45050950
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38512514
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38284899
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37513680
48FOXP3_21729870_ChIP-Seq_TREG_Human1.36759841
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35577002
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31634380
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29322570
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28773565
53CLOCK_20551151_ChIP-Seq_293T_Human1.28041407
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27059700
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26583497
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25149870
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25115685
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23017421
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21448834
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21298924
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21169806
62KDM5A_27292631_Chip-Seq_BREAST_Human1.21035623
63CIITA_25753668_ChIP-Seq_RAJI_Human1.19822033
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18860284
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18793159
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16690469
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15868238
68* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13487749
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12430064
70ZNF263_19887448_ChIP-Seq_K562_Human1.12308081
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.11972494
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11784909
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10728890
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10216154
75MYC_22102868_ChIP-Seq_BL_Human1.09869812
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08133145
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.07247021
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06268956
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04955523
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04527789
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.02056130
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00743696
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00622634
84EWS_26573619_Chip-Seq_HEK293_Human0.99726536
85MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99282992
86CHD1_26751641_Chip-Seq_LNCaP_Human0.98850014
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.97365037
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97112314
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96994939
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96099199
91* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95958856
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95813320
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.95712887
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95419255
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.94797043
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94654372
97* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93765840
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93106678
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90546748
100TFEB_21752829_ChIP-Seq_HELA_Human0.89558476
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.89435068
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89180109
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89102717
104* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87878051
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86570626
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86503514
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86387440
108MYC_18940864_ChIP-ChIP_HL60_Human0.86240786
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86064375
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85834117
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.84940274
112YY1_21170310_ChIP-Seq_MESCs_Mouse0.84770539
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84675651
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84067221
115SPI1_23547873_ChIP-Seq_NB4_Human0.83894052
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83853561
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83201372
118* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83087620
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83017410
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82377047
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80848054
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80350065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.62284087
2MP0010234_abnormal_vibrissa_follicle3.04435456
3MP0003693_abnormal_embryo_hatching2.84150944
4MP0010094_abnormal_chromosome_stability2.81593744
5MP0003077_abnormal_cell_cycle2.65596020
6MP0004957_abnormal_blastocyst_morpholog2.64783822
7MP0003111_abnormal_nucleus_morphology2.64701428
8MP0008007_abnormal_cellular_replicative2.51362154
9MP0008932_abnormal_embryonic_tissue2.36231916
10MP0008057_abnormal_DNA_replication2.19084347
11MP0003566_abnormal_cell_adhesion2.11038143
12MP0010030_abnormal_orbit_morphology1.80828321
13MP0008058_abnormal_DNA_repair1.75516859
14MP0009379_abnormal_foot_pigmentation1.74502654
15MP0000537_abnormal_urethra_morphology1.70074315
16MP0002102_abnormal_ear_morphology1.68851312
17MP0009697_abnormal_copulation1.65438441
18MP0000350_abnormal_cell_proliferation1.62557077
19MP0003567_abnormal_fetal_cardiomyocyte1.62278886
20MP0001730_embryonic_growth_arrest1.59163220
21MP0009278_abnormal_bone_marrow1.56068814
22MP0009672_abnormal_birth_weight1.52958988
23MP0003121_genomic_imprinting1.50534111
24MP0002163_abnormal_gland_morphology1.49627231
25MP0005058_abnormal_lysosome_morphology1.49615748
26MP0010352_gastrointestinal_tract_polyps1.46439641
27MP0005379_endocrine/exocrine_gland_phen1.45720668
28MP0003937_abnormal_limbs/digits/tail_de1.45548599
29MP0008438_abnormal_cutaneous_collagen1.44392833
30MP0001853_heart_inflammation1.44263155
31MP0006054_spinal_hemorrhage1.42161552
32MP0000358_abnormal_cell_content/1.38672454
33MP0003385_abnormal_body_wall1.37648630
34MP0003123_paternal_imprinting1.37143793
35MP0008877_abnormal_DNA_methylation1.36448169
36MP0003315_abnormal_perineum_morphology1.35814829
37MP0009250_abnormal_appendicular_skeleto1.35564244
38MP0002085_abnormal_embryonic_tissue1.34117594
39MP0001697_abnormal_embryo_size1.32205784
40MP0002938_white_spotting1.30517559
41MP0004808_abnormal_hematopoietic_stem1.26997750
42MP0003806_abnormal_nucleotide_metabolis1.24758462
43MP0004272_abnormal_basement_membrane1.23808539
44MP0002084_abnormal_developmental_patter1.19804666
45MP0005384_cellular_phenotype1.19021507
46MP0000733_abnormal_muscle_development1.18289910
47MP0003786_premature_aging1.17859856
48MP0002396_abnormal_hematopoietic_system1.17781016
49MP0005621_abnormal_cell_physiology1.17697290
50MP0005623_abnormal_meninges_morphology1.15455223
51MP0005380_embryogenesis_phenotype1.15313304
52MP0001672_abnormal_embryogenesis/_devel1.15313304
53MP0009053_abnormal_anal_canal1.13459050
54MP0003755_abnormal_palate_morphology1.12403116
55MP0003984_embryonic_growth_retardation1.11879267
56MP0000428_abnormal_craniofacial_morphol1.11455494
57MP0002088_abnormal_embryonic_growth/wei1.10482479
58MP0002006_tumorigenesis1.10053748
59MP0006035_abnormal_mitochondrial_morpho1.07696454
60MP0002060_abnormal_skin_morphology1.07659674
61MP0002080_prenatal_lethality1.07275066
62MP0000778_abnormal_nervous_system1.06005286
63MP0005503_abnormal_tendon_morphology1.04856491
64MP0004197_abnormal_fetal_growth/weight/1.04806884
65MP0003941_abnormal_skin_development1.03861201
66MP0002254_reproductive_system_inflammat1.03238024
67MP0001299_abnormal_eye_distance/1.02843333
68MP0002751_abnormal_autonomic_nervous1.02189400
69MP0008260_abnormal_autophagy1.01839000
70MP0009333_abnormal_splenocyte_physiolog1.01245743
71MP0003861_abnormal_nervous_system1.00094995
72MP0005501_abnormal_skin_physiology0.98071062
73MP0000049_abnormal_middle_ear0.96826614
74MP0003890_abnormal_embryonic-extraembry0.95937446
75MP0003221_abnormal_cardiomyocyte_apopto0.95014748
76MP0000490_abnormal_crypts_of0.94917616
77MP0003942_abnormal_urinary_system0.93509330
78MP0004264_abnormal_extraembryonic_tissu0.93466922
79MP0003091_abnormal_cell_migration0.92663107
80MP0001216_abnormal_epidermal_layer0.91796114
81MP0001293_anophthalmia0.90665396
82MP0004233_abnormal_muscle_weight0.89674507
83MP0002166_altered_tumor_susceptibility0.89627368
84MP0005397_hematopoietic_system_phenotyp0.89414678
85MP0001545_abnormal_hematopoietic_system0.89414678
86MP0002086_abnormal_extraembryonic_tissu0.89389180
87MP0002282_abnormal_trachea_morphology0.89275487
88MP0002116_abnormal_craniofacial_bone0.89017366
89MP0000383_abnormal_hair_follicle0.88550807
90MP0003935_abnormal_craniofacial_develop0.87811167
91MP0000372_irregular_coat_pigmentation0.87519349
92MP0003943_abnormal_hepatobiliary_system0.87041534
93MP0003950_abnormal_plasma_membrane0.86946885
94MP0003453_abnormal_keratinocyte_physiol0.86420566
95MP0009703_decreased_birth_body0.85374965
96MP0002009_preneoplasia0.85317920
97MP0003300_gastrointestinal_ulcer0.83818948
98MP0002932_abnormal_joint_morphology0.83817661
99MP0005076_abnormal_cell_differentiation0.83646683
100MP0005408_hypopigmentation0.83616868
101MP0000432_abnormal_head_morphology0.83592734
102MP0000313_abnormal_cell_death0.83474756
103MP0004134_abnormal_chest_morphology0.82837078
104MP0001188_hyperpigmentation0.82576915
105MP0002177_abnormal_outer_ear0.82570505
106MP0004147_increased_porphyrin_level0.80863258
107MP0001243_abnormal_dermal_layer0.80680787
108MP0003705_abnormal_hypodermis_morpholog0.80502097
109MP0004185_abnormal_adipocyte_glucose0.80429723
110MP0003279_aneurysm0.79263131
111MP0001727_abnormal_embryo_implantation0.78733600
112MP0000627_abnormal_mammary_gland0.78437118
113MP0005171_absent_coat_pigmentation0.78382408
114MP0005508_abnormal_skeleton_morphology0.78267491
115MP0002111_abnormal_tail_morphology0.78165736
116MP0001661_extended_life_span0.77786624
117MP0002796_impaired_skin_barrier0.77703965
118MP0005257_abnormal_intraocular_pressure0.77542667
119MP0001286_abnormal_eye_development0.76925705
120MP0003938_abnormal_ear_development0.76511871
121MP0001915_intracranial_hemorrhage0.75774273
122MP0003448_altered_tumor_morphology0.75629547
123MP0001879_abnormal_lymphatic_vessel0.75573686
124MP0001881_abnormal_mammary_gland0.75316838
125MP0000534_abnormal_ureter_morphology0.74646062
126MP0003763_abnormal_thymus_physiology0.74311745
127MP0008789_abnormal_olfactory_epithelium0.73443583
128MP0002210_abnormal_sex_determination0.72705275
129MP0003119_abnormal_digestive_system0.72281781
130MP0000858_altered_metastatic_potential0.71864155
131MP0010307_abnormal_tumor_latency0.71754446
132MP0000703_abnormal_thymus_morphology0.71604950
133MP0002925_abnormal_cardiovascular_devel0.71185516
134MP0001958_emphysema0.69915937
135MP0003718_maternal_effect0.69715710
136MP0002019_abnormal_tumor_incidence0.69665163
137MP0000647_abnormal_sebaceous_gland0.69574077
138MP0002092_abnormal_eye_morphology0.69021212
139MP0010678_abnormal_skin_adnexa0.68093885
140MP0005464_abnormal_platelet_physiology0.67554666
141MP0002081_perinatal_lethality0.67389738
142MP0000377_abnormal_hair_follicle0.65759064
143MP0000015_abnormal_ear_pigmentation0.65188574
144MP0002697_abnormal_eye_size0.63635742
145MP0004782_abnormal_surfactant_physiolog0.63455493
146MP0005197_abnormal_uvea_morphology0.62460914
147MP0001929_abnormal_gametogenesis0.62012008
148MP0005248_abnormal_Harderian_gland0.61576644
149MP0003186_abnormal_redox_activity0.61361585
150MP0001186_pigmentation_phenotype0.56902414
151MP0001346_abnormal_lacrimal_gland0.54123717
152MP0001145_abnormal_male_reproductive0.53951013

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)3.20412674
2Birth length less than 3rd percentile (HP:0003561)3.13535539
3Orthostatic hypotension (HP:0001278)2.99472062
4Colon cancer (HP:0003003)2.96360399
5Hypoglycemic coma (HP:0001325)2.88328758
6Short 4th metacarpal (HP:0010044)2.83794494
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.83794494
8Symptomatic seizures (HP:0011145)2.76339520
9Upper limb muscle weakness (HP:0003484)2.67754088
10Asymmetry of the thorax (HP:0001555)2.58768400
11Deep philtrum (HP:0002002)2.58582126
12Cutaneous melanoma (HP:0012056)2.53756114
13Prominent metopic ridge (HP:0005487)2.44535082
14Premature rupture of membranes (HP:0001788)2.44486336
15Transitional cell carcinoma of the bladder (HP:0006740)2.42917953
16Breast hypoplasia (HP:0003187)2.41677496
17Microvesicular hepatic steatosis (HP:0001414)2.38584390
18Progressive hearing impairment (HP:0001730)2.37443875
19Papillary thyroid carcinoma (HP:0002895)2.37381947
20Unilateral renal agenesis (HP:0000122)2.36021303
21Multiple enchondromatosis (HP:0005701)2.35967058
22Facial hemangioma (HP:0000329)2.34748971
23Leiomyosarcoma (HP:0100243)2.32060701
24Uterine leiomyosarcoma (HP:0002891)2.32060701
25Hypokinesia (HP:0002375)2.31035705
26Urethral obstruction (HP:0000796)2.30421209
27Patellar aplasia (HP:0006443)2.30180057
28Spastic diplegia (HP:0001264)2.28109485
29Proximal placement of thumb (HP:0009623)2.25209683
30Pancreatic islet-cell hyperplasia (HP:0004510)2.24227362
31Abnormality of the pancreatic islet cells (HP:0006476)2.23040557
32Abnormality of endocrine pancreas physiology (HP:0012093)2.23040557
33Glossoptosis (HP:0000162)2.21051239
34Overlapping toe (HP:0001845)2.19353901
35Bladder neoplasm (HP:0009725)2.19101827
36Bladder carcinoma (HP:0002862)2.19101827
37Abnormality of the preputium (HP:0100587)2.18670033
38Deviation of the thumb (HP:0009603)2.17921398
39Aplasia/Hypoplasia of the patella (HP:0006498)2.17396660
40Hyperinsulinemic hypoglycemia (HP:0000825)2.16829671
41Shoulder girdle muscle weakness (HP:0003547)2.15849985
42Selective tooth agenesis (HP:0001592)2.15108902
43Pelvic girdle muscle weakness (HP:0003749)2.12156283
44Thyroid carcinoma (HP:0002890)2.11554712
45Progressive external ophthalmoplegia (HP:0000590)2.11266089
46Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.11182091
47Volvulus (HP:0002580)2.10902184
48Abnormalities of placenta or umbilical cord (HP:0001194)2.10166427
49Atresia of the external auditory canal (HP:0000413)2.08244856
50Shallow orbits (HP:0000586)2.08236462
51Termporal pattern (HP:0011008)2.07253305
52Insidious onset (HP:0003587)2.07253305
53Abnormality of the musculature of the pelvis (HP:0001469)2.06215217
54Abnormality of the hip-girdle musculature (HP:0001445)2.06215217
55Progressive muscle weakness (HP:0003323)2.06186066
56Cerebral hypomyelination (HP:0006808)2.05810001
57Uterine neoplasm (HP:0010784)2.05531013
58Sparse eyelashes (HP:0000653)2.05345780
59Increased nuchal translucency (HP:0010880)2.04079916
60Tetraparesis (HP:0002273)2.01043873
61Microglossia (HP:0000171)2.00956902
62Abnormality of methionine metabolism (HP:0010901)2.00580955
63Malignant gastrointestinal tract tumors (HP:0006749)1.95289329
64Abnormal gallbladder physiology (HP:0012438)1.95200636
65Cholecystitis (HP:0001082)1.95200636
66Ectopic kidney (HP:0000086)1.94071682
67Myelodysplasia (HP:0002863)1.93764231
68Abnormality of the metopic suture (HP:0005556)1.92686664
69Wrist flexion contracture (HP:0001239)1.91881384
70Soft skin (HP:0000977)1.91831853
71Short middle phalanx of the 5th finger (HP:0004220)1.90671070
72Abnormality of the anterior horn cell (HP:0006802)1.90138533
73Degeneration of anterior horn cells (HP:0002398)1.90138533
74Abnormality of the labia minora (HP:0012880)1.89953350
75Abnormality of oral frenula (HP:0000190)1.89804158
76Protrusio acetabuli (HP:0003179)1.89347018
77Rhabdomyosarcoma (HP:0002859)1.86148442
78Abnormal lung lobation (HP:0002101)1.85836364
79Increased density of long bones (HP:0006392)1.85189541
80Abnormal foot bone ossification (HP:0010675)1.84577993
81Increased mean platelet volume (HP:0011877)1.82698729
82Ankyloglossia (HP:0010296)1.82173801
83Entropion (HP:0000621)1.81316578
84Neoplasm of the adrenal gland (HP:0100631)1.80754864
85Slender long bone (HP:0003100)1.80684297
86Abnormality of the 4th metacarpal (HP:0010012)1.80503847
87Adrenal hypoplasia (HP:0000835)1.79367449
88Progressive sensorineural hearing impairment (HP:0000408)1.79201643
89Reticulocytopenia (HP:0001896)1.79061542
90Double outlet right ventricle (HP:0001719)1.77647913
91Congenital malformation of the right heart (HP:0011723)1.77647913
92Chromsome breakage (HP:0040012)1.77270774
93Abnormality of the calcaneus (HP:0008364)1.77150364
94Fatigue (HP:0012378)1.75945837
95Calcaneovalgus deformity (HP:0001848)1.74777967
96Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74540763
97Abnormality of the duodenum (HP:0002246)1.73838977
98Abnormality of the distal phalanges of the toes (HP:0010182)1.72593734
99Medulloblastoma (HP:0002885)1.72584888
100Abnormal auditory evoked potentials (HP:0006958)1.72177999
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.71803600
102Tongue fasciculations (HP:0001308)1.71579437
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.71461054
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71277308
105Hyperglycemia (HP:0003074)1.70483560
106Septate vagina (HP:0001153)1.66396896
107Trigonocephaly (HP:0000243)1.66246244
108Ovarian neoplasm (HP:0100615)1.65546140
109Limb-girdle muscle atrophy (HP:0003797)1.64688441
110Renal cell carcinoma (HP:0005584)1.63388114
11111 pairs of ribs (HP:0000878)1.62730385
112Absent radius (HP:0003974)1.60252296
113Abnormality of the umbilical cord (HP:0010881)1.59999860
114Neoplasm of the pancreas (HP:0002894)1.59196919
115Ankle contracture (HP:0006466)1.57763970
116Oligodactyly (HP:0012165)1.57405648
117Deformed tarsal bones (HP:0008119)1.56325844
118Absent forearm bone (HP:0003953)1.55512772
119Aplasia involving forearm bones (HP:0009822)1.55512772
120Premature graying of hair (HP:0002216)1.55437044
121Cortical dysplasia (HP:0002539)1.55332410
122Lissencephaly (HP:0001339)1.54115697
123Abnormal number of incisors (HP:0011064)1.53508959
124Increased serum pyruvate (HP:0003542)1.53361329
125Abnormality of glycolysis (HP:0004366)1.53361329
126Capillary hemangiomas (HP:0005306)1.53151763
127Aplastic anemia (HP:0001915)1.52916201
128Chin dimple (HP:0010751)1.52633080
129Rough bone trabeculation (HP:0100670)1.52377463
130High anterior hairline (HP:0009890)1.51476643
131Chromosomal breakage induced by crosslinking agents (HP:0003221)1.51303756
132Increased number of teeth (HP:0011069)1.46782912
133Abnormality of chromosome stability (HP:0003220)1.45260259
134Meckel diverticulum (HP:0002245)1.43663725
135Irregular epiphyses (HP:0010582)1.43473091
136Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.43266091
137Absent epiphyses (HP:0010577)1.43266091
138Small intestinal stenosis (HP:0012848)1.43229016
139Duodenal stenosis (HP:0100867)1.43229016
140Embryonal renal neoplasm (HP:0011794)1.42162578
141Secondary amenorrhea (HP:0000869)1.42133610
142Abnormal umbilical cord blood vessels (HP:0011403)1.42026704
143Single umbilical artery (HP:0001195)1.42026704
144Abnormality of the fetal cardiovascular system (HP:0010948)1.42026704
145Heterochromia iridis (HP:0001100)1.41783177
146Delayed cranial suture closure (HP:0000270)1.41468246
147Aortic dissection (HP:0002647)1.41420678
148Abnormality of abdominal situs (HP:0011620)1.41399068
149Abdominal situs inversus (HP:0003363)1.41399068
150Mild short stature (HP:0003502)1.41309639
151Hypoplastic pelvis (HP:0008839)1.41300482
152Trismus (HP:0000211)1.41287638
153Optic nerve coloboma (HP:0000588)1.41156347
154Parakeratosis (HP:0001036)1.40102901
155Postnatal microcephaly (HP:0005484)1.40075986
156Aplasia/Hypoplasia of the earlobes (HP:0009906)1.39456909
157Stenosis of the external auditory canal (HP:0000402)1.38612779
158Abnormality of the peritoneum (HP:0002585)1.38286020
159Triphalangeal thumb (HP:0001199)1.37776984
160Nephroblastoma (Wilms tumor) (HP:0002667)1.37719728
161Disinhibition (HP:0000734)1.37558586
162Abnormality of the ileum (HP:0001549)1.35817717
163Microtia (HP:0008551)1.35806415
164Gastrointestinal carcinoma (HP:0002672)1.34799369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.65428278
2CDC73.12165306
3TESK23.04136036
4LIMK12.89298975
5NEK12.68237016
6MARK12.65417448
7WEE12.53258698
8ACVR1B2.52669146
9DYRK22.47479189
10NEK22.40925292
11MKNK12.34397272
12EIF2AK12.25910205
13IRAK32.04728779
14PLK42.01439883
15TESK11.88662720
16ERBB31.85708015
17TRIM281.82599870
18TGFBR11.74340379
19SRPK11.74306010
20BCR1.73600135
21TAF11.69761921
22STK101.60268773
23MAP3K141.59129839
24VRK21.54343819
25BMPR1B1.54038940
26TSSK61.52943256
27CDK121.49505688
28PLK31.49109412
29TTK1.44302944
30MKNK21.44225329
31NME21.43456451
32CSNK1G31.41893439
33DYRK31.40294964
34PLK11.37872827
35SMG11.33425474
36ERBB41.30657322
37AURKB1.30185797
38STK161.28969362
39PNCK1.26440059
40MELK1.21326503
41CDK81.20857591
42CHEK21.19980632
43SIK31.19753411
44CSNK1A1L1.17143214
45VRK11.16822808
46PIM21.15842193
47AURKA1.15682440
48MAP3K131.13116162
49BRSK21.13101547
50BRD41.12605602
51ATR1.12296742
52CLK11.11510648
53PASK1.05254719
54MAP3K81.05241371
55PAK41.04677142
56CSNK1G11.01410780
57EPHA21.00920041
58CCNB11.00690995
59STK38L1.00124726
60SCYL20.98331748
61MAPK130.98261754
62LATS20.96181073
63STK30.95488139
64EPHB20.95463744
65CDK140.95293291
66EIF2AK20.95280661
67CSNK1G20.93646192
68CDK70.92950469
69PBK0.91258647
70TLK10.89135772
71BRSK10.87197149
72EIF2AK30.86688714
73CHEK10.83050213
74MST40.81890038
75BRAF0.80635849
76STK390.80396968
77KDR0.77260261
78STK240.77055467
79ARAF0.76499031
80ILK0.75938237
81MOS0.74119775
82MAP3K120.73497291
83UHMK10.73411706
84LRRK20.72263624
85MAP3K90.71415161
86PAK10.71228089
87RPS6KA40.70903486
88CDK180.69894638
89PTK20.67935538
90CDK150.67683449
91PLK20.66709435
92RPS6KB20.63365173
93MET0.63243696
94PAK20.62962733
95BMPR20.62780437
96NEK90.62733041
97PDGFRA0.62640677
98CDK11A0.61962906
99CDK10.58139688
100NUAK10.57482335
101ICK0.57254893
102CDK60.57142275
103ROCK20.56784701
104ATM0.55463850
105MAP3K100.54639207
106MINK10.54142057
107STK40.54120405
108CDK20.53866762
109LATS10.52278190
110PDK20.51913145
111KSR10.50058586
112NLK0.47694409
113YES10.47607440
114TYRO30.45632636
115RAF10.44248316
116KSR20.43244484
117FGFR10.42414633
118AKT20.39796122
119ALK0.39622657
120CDK90.36913206
121DAPK10.36627477
122PKN20.36254154
123CSNK2A10.35465706
124FLT30.35048654
125TAOK20.35007400
126CSNK2A20.34534806
127EPHB10.33610535
128ROCK10.33083412
129DYRK1B0.31089783
130MAPK90.29010943
131PRKCI0.28462451
132PIM10.28053366
133DMPK0.27564633
134CDK40.27355066

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.00979923
2Proteasome_Homo sapiens_hsa030502.71059477
3Cell cycle_Homo sapiens_hsa041102.63874763
4Mismatch repair_Homo sapiens_hsa034302.49824856
5Spliceosome_Homo sapiens_hsa030402.43048551
6RNA transport_Homo sapiens_hsa030132.16092689
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.15229969
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06293529
9Base excision repair_Homo sapiens_hsa034102.00734185
10Nucleotide excision repair_Homo sapiens_hsa034202.00444525
11RNA polymerase_Homo sapiens_hsa030202.00036732
12Homologous recombination_Homo sapiens_hsa034401.82787272
13Ribosome_Homo sapiens_hsa030101.79636416
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70802483
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70067696
16Basal transcription factors_Homo sapiens_hsa030221.64671251
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58740306
18p53 signaling pathway_Homo sapiens_hsa041151.58522965
19mRNA surveillance pathway_Homo sapiens_hsa030151.56477986
20Folate biosynthesis_Homo sapiens_hsa007901.53502533
21Fatty acid elongation_Homo sapiens_hsa000621.46904368
22Viral myocarditis_Homo sapiens_hsa054161.42822789
23Fanconi anemia pathway_Homo sapiens_hsa034601.35501531
24RNA degradation_Homo sapiens_hsa030181.33061137
25Colorectal cancer_Homo sapiens_hsa052101.31470957
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30755766
27Epstein-Barr virus infection_Homo sapiens_hsa051691.28652506
28Shigellosis_Homo sapiens_hsa051311.27855870
29MicroRNAs in cancer_Homo sapiens_hsa052061.26929800
30Non-homologous end-joining_Homo sapiens_hsa034501.24555915
31Oocyte meiosis_Homo sapiens_hsa041141.24201370
32Hippo signaling pathway_Homo sapiens_hsa043901.22236674
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19388980
34Pyrimidine metabolism_Homo sapiens_hsa002401.19060369
35TGF-beta signaling pathway_Homo sapiens_hsa043501.17745748
36Vibrio cholerae infection_Homo sapiens_hsa051101.13548345
37Vitamin B6 metabolism_Homo sapiens_hsa007501.12387474
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11350179
39Pentose phosphate pathway_Homo sapiens_hsa000301.09448248
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07803779
41Viral carcinogenesis_Homo sapiens_hsa052031.05179876
42Axon guidance_Homo sapiens_hsa043601.04803528
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03600516
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.02349666
45HTLV-I infection_Homo sapiens_hsa051661.01378926
46Small cell lung cancer_Homo sapiens_hsa052221.00774823
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97551908
48Basal cell carcinoma_Homo sapiens_hsa052170.94463140
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.92463767
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91839050
51Renal cell carcinoma_Homo sapiens_hsa052110.91225251
52Pancreatic cancer_Homo sapiens_hsa052120.89521647
53Adherens junction_Homo sapiens_hsa045200.89454225
54Chronic myeloid leukemia_Homo sapiens_hsa052200.88513470
55Biosynthesis of amino acids_Homo sapiens_hsa012300.87803338
56Protein export_Homo sapiens_hsa030600.84313554
57Carbon metabolism_Homo sapiens_hsa012000.82979729
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.82270543
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81809998
60Selenocompound metabolism_Homo sapiens_hsa004500.79552402
61Hedgehog signaling pathway_Homo sapiens_hsa043400.79530050
62Herpes simplex infection_Homo sapiens_hsa051680.78994188
63Antigen processing and presentation_Homo sapiens_hsa046120.78727589
64Tight junction_Homo sapiens_hsa045300.77836314
65Hepatitis B_Homo sapiens_hsa051610.77354894
66Apoptosis_Homo sapiens_hsa042100.75570943
67Focal adhesion_Homo sapiens_hsa045100.74979405
68ECM-receptor interaction_Homo sapiens_hsa045120.73669560
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73639718
70Pathways in cancer_Homo sapiens_hsa052000.72824916
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72217839
72Proteoglycans in cancer_Homo sapiens_hsa052050.71823545
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71161104
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70678203
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69603617
76Prostate cancer_Homo sapiens_hsa052150.69220318
77Wnt signaling pathway_Homo sapiens_hsa043100.68701521
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68683389
79Salmonella infection_Homo sapiens_hsa051320.68543265
80Endometrial cancer_Homo sapiens_hsa052130.67915103
81Thyroid cancer_Homo sapiens_hsa052160.67595770
82T cell receptor signaling pathway_Homo sapiens_hsa046600.67069495
83Non-small cell lung cancer_Homo sapiens_hsa052230.67053855
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64127385
85Measles_Homo sapiens_hsa051620.62273178
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62130429
87Endocytosis_Homo sapiens_hsa041440.61514021
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.60343775
89Legionellosis_Homo sapiens_hsa051340.59773710
90Steroid biosynthesis_Homo sapiens_hsa001000.57330403
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57307986
92Melanoma_Homo sapiens_hsa052180.57159278
93Glutathione metabolism_Homo sapiens_hsa004800.56867428
94Hematopoietic cell lineage_Homo sapiens_hsa046400.56269008
95Notch signaling pathway_Homo sapiens_hsa043300.56130021
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55437423
97One carbon pool by folate_Homo sapiens_hsa006700.55108209
98Toxoplasmosis_Homo sapiens_hsa051450.54914304
99Purine metabolism_Homo sapiens_hsa002300.54417826
100Autoimmune thyroid disease_Homo sapiens_hsa053200.54403789
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53700981
102Phagosome_Homo sapiens_hsa041450.53567863
103Leishmaniasis_Homo sapiens_hsa051400.52871286
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52792628
105Systemic lupus erythematosus_Homo sapiens_hsa053220.52068338
106Platelet activation_Homo sapiens_hsa046110.51786029
107Malaria_Homo sapiens_hsa051440.51307684
108Alcoholism_Homo sapiens_hsa050340.50854513
109Sulfur metabolism_Homo sapiens_hsa009200.50786078
110VEGF signaling pathway_Homo sapiens_hsa043700.48424402
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48123896
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47972794
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.47482966
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.47423179
115Galactose metabolism_Homo sapiens_hsa000520.46695225
116Sphingolipid metabolism_Homo sapiens_hsa006000.45486892
117Bladder cancer_Homo sapiens_hsa052190.45369334
118Primary immunodeficiency_Homo sapiens_hsa053400.45285079
119N-Glycan biosynthesis_Homo sapiens_hsa005100.44328479
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43678232
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42682177
122Pyruvate metabolism_Homo sapiens_hsa006200.42639519
123B cell receptor signaling pathway_Homo sapiens_hsa046620.42590293
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42102170
125Pertussis_Homo sapiens_hsa051330.41517151
126Other glycan degradation_Homo sapiens_hsa005110.38358703
127Lysosome_Homo sapiens_hsa041420.38094531
128HIF-1 signaling pathway_Homo sapiens_hsa040660.37822908
129Collecting duct acid secretion_Homo sapiens_hsa049660.33163075
130Acute myeloid leukemia_Homo sapiens_hsa052210.29835544
131Influenza A_Homo sapiens_hsa051640.27550760
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26284155
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25840946
134mTOR signaling pathway_Homo sapiens_hsa041500.25211655
135Glioma_Homo sapiens_hsa052140.24594606
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24111369

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