MAPRE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.83240518
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.41426076
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.34764332
4synaptic vesicle exocytosis (GO:0016079)5.28162053
5locomotory exploration behavior (GO:0035641)5.23591681
6regulation of synaptic vesicle exocytosis (GO:2000300)5.03350638
7vocalization behavior (GO:0071625)4.89516896
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89426763
9glutamate secretion (GO:0014047)4.87162622
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.74106165
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.62915111
12neuron cell-cell adhesion (GO:0007158)4.50308690
13protein localization to synapse (GO:0035418)4.48810397
14regulation of synaptic vesicle transport (GO:1902803)4.47417866
15regulation of synapse structural plasticity (GO:0051823)4.42022416
16regulation of glutamate receptor signaling pathway (GO:1900449)4.32791635
17layer formation in cerebral cortex (GO:0021819)4.29739671
18exploration behavior (GO:0035640)4.23056258
19neurotransmitter secretion (GO:0007269)4.09601648
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.95081829
21regulation of neuronal synaptic plasticity (GO:0048168)3.82810725
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79941273
23neuronal action potential propagation (GO:0019227)3.74679878
24neurotransmitter-gated ion channel clustering (GO:0072578)3.71996860
25nucleobase catabolic process (GO:0046113)3.71766159
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69703465
27proline transport (GO:0015824)3.68349679
28synaptic transmission, glutamatergic (GO:0035249)3.62720773
29dendritic spine morphogenesis (GO:0060997)3.61775188
30glutamate receptor signaling pathway (GO:0007215)3.59784573
31neuron recognition (GO:0008038)3.58151075
32dendrite morphogenesis (GO:0048813)3.57447477
33negative regulation of microtubule polymerization (GO:0031115)3.56402764
34cellular potassium ion homeostasis (GO:0030007)3.53511117
35positive regulation of synapse maturation (GO:0090129)3.53485690
36activation of protein kinase A activity (GO:0034199)3.53139225
37neuron-neuron synaptic transmission (GO:0007270)3.50255633
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48619630
39detection of calcium ion (GO:0005513)3.48613989
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46926842
41gamma-aminobutyric acid transport (GO:0015812)3.44225115
42response to pheromone (GO:0019236)3.43918107
43postsynaptic membrane organization (GO:0001941)3.38970552
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36611779
45positive regulation of membrane potential (GO:0045838)3.35850139
46long-term memory (GO:0007616)3.34553995
47cerebellar Purkinje cell differentiation (GO:0021702)3.32849467
48synaptic vesicle endocytosis (GO:0048488)3.31392299
49axonal fasciculation (GO:0007413)3.30836161
50sodium ion export (GO:0071436)3.30122318
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29124217
52neurotransmitter transport (GO:0006836)3.28940258
53cell migration in hindbrain (GO:0021535)3.26584499
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25908814
55regulation of neurotransmitter secretion (GO:0046928)3.25895630
56protein K11-linked deubiquitination (GO:0035871)3.25317515
57serotonin receptor signaling pathway (GO:0007210)3.20380039
58cell communication by electrical coupling (GO:0010644)3.19382888
59regulation of postsynaptic membrane potential (GO:0060078)3.17060056
60auditory behavior (GO:0031223)3.16385870
61pyrimidine nucleobase catabolic process (GO:0006208)3.15023457
62cerebellar granule cell differentiation (GO:0021707)3.14447245
63regulation of synaptic plasticity (GO:0048167)3.11507684
64neuromuscular process controlling balance (GO:0050885)3.11384534
65response to auditory stimulus (GO:0010996)3.09050572
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03994262
67regulation of vesicle fusion (GO:0031338)3.02757040
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.01691793
69regulation of neurotransmitter levels (GO:0001505)3.01647535
70organelle transport along microtubule (GO:0072384)3.00968007
71startle response (GO:0001964)3.00903901
72regulation of neurotransmitter transport (GO:0051588)3.00867111
73long-term synaptic potentiation (GO:0060291)3.00673853
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00625025
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99803902
76synapse assembly (GO:0007416)2.98473772
77membrane depolarization during action potential (GO:0086010)2.98100423
78glycosphingolipid biosynthetic process (GO:0006688)2.97613311
79vesicle transport along microtubule (GO:0047496)2.96534971
80gamma-aminobutyric acid signaling pathway (GO:0007214)2.96532095
81neurofilament cytoskeleton organization (GO:0060052)2.96435014
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96377246
83transmission of nerve impulse (GO:0019226)2.94828824
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94702097
85membrane hyperpolarization (GO:0060081)2.94195646
86axon cargo transport (GO:0008088)2.93803378
87axon ensheathment in central nervous system (GO:0032291)2.93384732
88central nervous system myelination (GO:0022010)2.93384732
89activated T cell proliferation (GO:0050798)2.93059520
90neuromuscular process controlling posture (GO:0050884)2.92113874
91presynaptic membrane assembly (GO:0097105)2.92111055
92regulation of dendritic spine morphogenesis (GO:0061001)2.90794598
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90087199
94neuronal ion channel clustering (GO:0045161)2.88988849
95membrane depolarization (GO:0051899)2.87960372
96innervation (GO:0060384)2.87837928
97regulation of voltage-gated calcium channel activity (GO:1901385)2.87587733
98positive regulation of potassium ion transmembrane transport (GO:1901381)2.87086606
99synaptic transmission (GO:0007268)2.85039453
100presynaptic membrane organization (GO:0097090)2.84172009
101nerve growth factor signaling pathway (GO:0038180)2.82302128
102positive regulation of neurotransmitter transport (GO:0051590)2.82052277
103synaptic vesicle transport (GO:0048489)2.81994206
104establishment of synaptic vesicle localization (GO:0097480)2.81994206
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81663520
106positive regulation of neurotransmitter secretion (GO:0001956)2.81240369
107neuromuscular synaptic transmission (GO:0007274)2.81180314
108establishment of mitochondrion localization (GO:0051654)2.80475566
109neurotransmitter uptake (GO:0001504)2.80139709
110regulation of synapse maturation (GO:0090128)2.79780915
111glycine transport (GO:0015816)2.79745912
112clathrin coat assembly (GO:0048268)2.79546815
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79189513
114dopamine receptor signaling pathway (GO:0007212)2.78782967
115regulation of ARF protein signal transduction (GO:0032012)2.78741223
116adult walking behavior (GO:0007628)2.76654227
117response to amphetamine (GO:0001975)2.73162592
118positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.71258417
119glycerophospholipid catabolic process (GO:0046475)2.70830069
120potassium ion import (GO:0010107)2.70781639
121negative regulation of heart rate (GO:0010459)2.69363508
122vesicle docking involved in exocytosis (GO:0006904)2.66665451
123neuronal action potential (GO:0019228)2.65867303
124mechanosensory behavior (GO:0007638)2.60110306
125positive regulation of dendritic spine development (GO:0060999)2.59478980
126regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.55381424
127regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.54006725
128potassium ion homeostasis (GO:0055075)2.53448593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01884594
2GBX2_23144817_ChIP-Seq_PC3_Human3.45677333
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07203553
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99282381
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96211502
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75425648
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65087660
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65087660
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54232941
10DROSHA_22980978_ChIP-Seq_HELA_Human2.50094407
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50082540
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49467667
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.49403499
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48092611
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47166838
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.46009792
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44278075
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.31676182
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.28005636
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24234904
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24132152
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22518859
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.16057771
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13765506
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.07796566
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01661892
27AR_21572438_ChIP-Seq_LNCaP_Human1.96555712
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94508363
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93539540
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91609176
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71806492
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68723188
33SMAD4_21799915_ChIP-Seq_A2780_Human1.60086122
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56334916
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53258086
36TAF15_26573619_Chip-Seq_HEK293_Human1.52952295
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50913930
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42953335
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40227703
40ZNF274_21170338_ChIP-Seq_K562_Hela1.39480182
41VDR_22108803_ChIP-Seq_LS180_Human1.38642010
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.37851146
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36973119
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.32754741
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32640186
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32034644
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.31925020
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31888983
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30515607
50P300_19829295_ChIP-Seq_ESCs_Human1.28735993
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28522822
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.28041916
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27355468
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26737514
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26471193
56IGF1R_20145208_ChIP-Seq_DFB_Human1.26382238
57FUS_26573619_Chip-Seq_HEK293_Human1.26231123
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25556134
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25523094
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25409910
61* AR_19668381_ChIP-Seq_PC3_Human1.24592825
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.23726915
63STAT3_23295773_ChIP-Seq_U87_Human1.22474031
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21534924
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.20060670
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19852625
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18774485
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17585420
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.17473545
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17120878
71AR_25329375_ChIP-Seq_VCAP_Human1.17054525
72HTT_18923047_ChIP-ChIP_STHdh_Human1.16471594
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15751357
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15581918
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13892588
76* KDM2B_26808549_Chip-Seq_K562_Human1.13819447
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12515366
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11791570
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11657347
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10892962
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.10844994
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10257252
83CBP_20019798_ChIP-Seq_JUKART_Human1.10257252
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09259640
85* CBX2_27304074_Chip-Seq_ESCs_Mouse1.08529825
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.07385772
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07192894
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06616382
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05906030
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05595637
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05184191
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04017601
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03837862
94ER_23166858_ChIP-Seq_MCF-7_Human1.03612999
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.03416478
96* TCF4_23295773_ChIP-Seq_U87_Human1.03013465
97P53_22387025_ChIP-Seq_ESCs_Mouse1.02210540
98JUN_21703547_ChIP-Seq_K562_Human1.02064217
99RNF2_27304074_Chip-Seq_NSC_Mouse1.01323246
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.01292761
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01086858
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99717719
103PIAS1_25552417_ChIP-Seq_VCAP_Human0.99596909
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.99197718
105BCAT_22108803_ChIP-Seq_LS180_Human0.99004472
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98439269
107AHR_22903824_ChIP-Seq_MCF-7_Human0.98385031
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.98175114
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97615763
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97489773
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.96905162
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96781068
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.96693708
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96472942
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96442650
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96383946
117TP53_22573176_ChIP-Seq_HFKS_Human0.95076512
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94794901
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92701429
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92468758
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92245689
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92015444
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90870788
124* EWS_26573619_Chip-Seq_HEK293_Human0.90799923
125* TET1_21490601_ChIP-Seq_MESCs_Mouse0.90731156
126* RUNX2_22187159_ChIP-Seq_PCA_Human0.90580309
127* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89035839
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86583430
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86583430
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85756939
131* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85561769
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83179476
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.82485646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.88000935
2MP0003880_abnormal_central_pattern4.20431726
3MP0003635_abnormal_synaptic_transmissio3.92445454
4MP0004270_analgesia3.91546925
5MP0002063_abnormal_learning/memory/cond3.17163826
6MP0009745_abnormal_behavioral_response3.04023313
7MP0005423_abnormal_somatic_nervous2.96148151
8MP0001968_abnormal_touch/_nociception2.94907648
9MP0002064_seizures2.91228274
10MP0009046_muscle_twitch2.88046669
11MP0002734_abnormal_mechanical_nocicepti2.78308211
12MP0002572_abnormal_emotion/affect_behav2.61253943
13MP0009780_abnormal_chondrocyte_physiolo2.46317519
14MP0002735_abnormal_chemical_nociception2.44389385
15MP0002272_abnormal_nervous_system2.41926595
16MP0001486_abnormal_startle_reflex2.35298215
17MP0002733_abnormal_thermal_nociception2.29312133
18MP0002736_abnormal_nociception_after2.24117316
19MP0001970_abnormal_pain_threshold2.11770463
20MP0000778_abnormal_nervous_system2.08576759
21MP0004858_abnormal_nervous_system2.04440829
22MP0002822_catalepsy2.04418796
23MP0003329_amyloid_beta_deposits2.03820624
24MP0002184_abnormal_innervation1.98415857
25MP0002067_abnormal_sensory_capabilities1.98015290
26MP0008569_lethality_at_weaning1.97422877
27MP0001440_abnormal_grooming_behavior1.94246397
28MP0004811_abnormal_neuron_physiology1.91314362
29MP0006276_abnormal_autonomic_nervous1.90373901
30MP0002909_abnormal_adrenal_gland1.90072147
31MP0001501_abnormal_sleep_pattern1.84469488
32MP0004924_abnormal_behavior1.80985668
33MP0005386_behavior/neurological_phenoty1.80985668
34MP0002557_abnormal_social/conspecific_i1.79357899
35MP0000955_abnormal_spinal_cord1.69718578
36MP0001984_abnormal_olfaction1.69405623
37MP0008877_abnormal_DNA_methylation1.64108284
38MP0002882_abnormal_neuron_morphology1.51811204
39MP0005646_abnormal_pituitary_gland1.50223024
40MP0003122_maternal_imprinting1.49474051
41MP0003787_abnormal_imprinting1.47294068
42MP0001529_abnormal_vocalization1.46692519
43MP0004885_abnormal_endolymph1.41512175
44MP0002066_abnormal_motor_capabilities/c1.40567108
45MP0003633_abnormal_nervous_system1.32213362
46MP0000751_myopathy1.29465556
47MP0001502_abnormal_circadian_rhythm1.27597023
48MP0002102_abnormal_ear_morphology1.27574606
49MP0000569_abnormal_digit_pigmentation1.27099882
50MP0003879_abnormal_hair_cell1.25312073
51MP0005645_abnormal_hypothalamus_physiol1.25217114
52MP0004147_increased_porphyrin_level1.23223848
53MP0005167_abnormal_blood-brain_barrier1.22933714
54MP0003121_genomic_imprinting1.19798406
55MP0002837_dystrophic_cardiac_calcinosis1.17337052
56MP0001905_abnormal_dopamine_level1.16546978
57MP0005464_abnormal_platelet_physiology1.16003263
58MP0002152_abnormal_brain_morphology1.14912030
59MP0004142_abnormal_muscle_tone1.14277315
60MP0003631_nervous_system_phenotype1.13544198
61MP0005551_abnormal_eye_electrophysiolog1.11846667
62MP0002229_neurodegeneration1.10196872
63MP0004145_abnormal_muscle_electrophysio1.09588252
64MP0001188_hyperpigmentation1.06261570
65MP0004215_abnormal_myocardial_fiber1.05252929
66MP0003634_abnormal_glial_cell1.01542071
67MP0004085_abnormal_heartbeat0.97772181
68MP0002638_abnormal_pupillary_reflex0.97420828
69MP0000013_abnormal_adipose_tissue0.97004852
70MP0003724_increased_susceptibility_to0.94181472
71MP0005394_taste/olfaction_phenotype0.94171613
72MP0005499_abnormal_olfactory_system0.94171613
73MP0003172_abnormal_lysosome_physiology0.92320738
74MP0000920_abnormal_myelination0.92169428
75MP0010386_abnormal_urinary_bladder0.91280788
76MP0000604_amyloidosis0.91016405
77MP0004742_abnormal_vestibular_system0.88535460
78MP0002069_abnormal_eating/drinking_beha0.87156529
79MP0003137_abnormal_impulse_conducting0.86074366
80MP0002752_abnormal_somatic_nervous0.84964628
81MP0004233_abnormal_muscle_weight0.83778610
82MP0003632_abnormal_nervous_system0.82692954
83MP0004130_abnormal_muscle_cell0.80673353
84MP0000631_abnormal_neuroendocrine_gland0.79601839
85MP0008961_abnormal_basal_metabolism0.79026289
86MP0002090_abnormal_vision0.78132136
87MP0004510_myositis0.78130882
88MP0005253_abnormal_eye_physiology0.77685230
89MP0004084_abnormal_cardiac_muscle0.77584723
90MP0003183_abnormal_peptide_metabolism0.76158992
91MP0000465_gastrointestinal_hemorrhage0.74734351
92MP0003283_abnormal_digestive_organ0.73907911
93MP0005535_abnormal_body_temperature0.73432242
94MP0000230_abnormal_systemic_arterial0.72672898
95MP0004484_altered_response_of0.72634280
96MP0001963_abnormal_hearing_physiology0.71794113
97MP0008874_decreased_physiological_sensi0.71603630
98MP0005084_abnormal_gallbladder_morpholo0.71442762
99MP0003646_muscle_fatigue0.71201495
100MP0006072_abnormal_retinal_apoptosis0.69952740
101MP0003690_abnormal_glial_cell0.67895910
102MP0000639_abnormal_adrenal_gland0.67014091
103MP0001299_abnormal_eye_distance/0.65477243
104MP0001986_abnormal_taste_sensitivity0.65352682
105MP0005187_abnormal_penis_morphology0.65310764
106MP0008872_abnormal_physiological_respon0.64074293
107MP0003075_altered_response_to0.63959599
108MP0001348_abnormal_lacrimal_gland0.62755129
109MP0003861_abnormal_nervous_system0.62471339
110MP0001177_atelectasis0.62013823
111MP0005409_darkened_coat_color0.61849906
112MP0004043_abnormal_pH_regulation0.61730029
113MP0004036_abnormal_muscle_relaxation0.60347264
114MP0002876_abnormal_thyroid_physiology0.59990934
115MP0002653_abnormal_ependyma_morphology0.58558711
116MP0005670_abnormal_white_adipose0.57682707
117MP0005671_abnormal_response_to0.56274792
118MP0008775_abnormal_heart_ventricle0.56097866

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.77679039
2Focal motor seizures (HP:0011153)5.76117927
3Visual hallucinations (HP:0002367)4.85596280
4Focal seizures (HP:0007359)4.83159006
5Epileptic encephalopathy (HP:0200134)4.34790300
6Supranuclear gaze palsy (HP:0000605)4.09234266
7Progressive cerebellar ataxia (HP:0002073)3.99317758
8Atonic seizures (HP:0010819)3.87833073
9Action tremor (HP:0002345)3.76694340
10Ankle clonus (HP:0011448)3.73323974
11Mutism (HP:0002300)3.69135656
12Febrile seizures (HP:0002373)3.68488831
13Absence seizures (HP:0002121)3.42817216
14Pheochromocytoma (HP:0002666)3.29745427
15Broad-based gait (HP:0002136)3.25084093
16Papilledema (HP:0001085)3.23462118
17Generalized tonic-clonic seizures (HP:0002069)3.21705873
18Depression (HP:0000716)3.16869455
19Poor eye contact (HP:0000817)3.15973006
20Dialeptic seizures (HP:0011146)3.14171786
21Limb dystonia (HP:0002451)3.08371428
22Abnormal eating behavior (HP:0100738)3.05486217
23Truncal ataxia (HP:0002078)3.02171064
24Urinary bladder sphincter dysfunction (HP:0002839)2.89585941
25Insidious onset (HP:0003587)2.88177852
26Termporal pattern (HP:0011008)2.88177852
27Neurofibrillary tangles (HP:0002185)2.86737606
28Abnormality of the corticospinal tract (HP:0002492)2.86477801
29Anxiety (HP:0000739)2.84127386
30Neuroendocrine neoplasm (HP:0100634)2.83563759
31Genetic anticipation (HP:0003743)2.83031805
32Impaired social interactions (HP:0000735)2.82826888
33Abnormal social behavior (HP:0012433)2.82826888
34Polyphagia (HP:0002591)2.81297956
35Dysmetria (HP:0001310)2.79480118
36Agitation (HP:0000713)2.75585357
37Drooling (HP:0002307)2.75209635
38Excessive salivation (HP:0003781)2.75209635
39Gaze-evoked nystagmus (HP:0000640)2.73954336
40Hyperventilation (HP:0002883)2.73623205
41Impaired vibration sensation in the lower limbs (HP:0002166)2.73513034
42Dysdiadochokinesis (HP:0002075)2.71799637
43Amyotrophic lateral sclerosis (HP:0007354)2.68618759
44Urinary urgency (HP:0000012)2.68481581
45Cerebral inclusion bodies (HP:0100314)2.62713411
46Diplopia (HP:0000651)2.62638302
47Abnormality of binocular vision (HP:0011514)2.62638302
48Spastic gait (HP:0002064)2.62291047
49Progressive inability to walk (HP:0002505)2.61863589
50Torticollis (HP:0000473)2.53672698
51Stereotypic behavior (HP:0000733)2.49789741
52Postural instability (HP:0002172)2.48698487
53Impaired smooth pursuit (HP:0007772)2.47221959
54Amblyopia (HP:0000646)2.44378659
55Cerebral hypomyelination (HP:0006808)2.42685428
56Epileptiform EEG discharges (HP:0011182)2.40532566
57Prolonged bleeding time (HP:0003010)2.39938013
58EEG with generalized epileptiform discharges (HP:0011198)2.38183985
59Lower limb muscle weakness (HP:0007340)2.36499604
60Scanning speech (HP:0002168)2.34770618
61Hemiparesis (HP:0001269)2.34420946
62Spastic tetraplegia (HP:0002510)2.30398191
63Hypsarrhythmia (HP:0002521)2.29940953
64Peripheral hypomyelination (HP:0007182)2.29486473
65Abnormality of the lower motor neuron (HP:0002366)2.26687812
66Apathy (HP:0000741)2.26133683
67Focal dystonia (HP:0004373)2.25469951
68Inappropriate behavior (HP:0000719)2.23867833
69Megalencephaly (HP:0001355)2.23248967
70Neoplasm of the peripheral nervous system (HP:0100007)2.18593534
71Intention tremor (HP:0002080)2.17261475
72Ventricular fibrillation (HP:0001663)2.15502352
73Abnormality of ocular smooth pursuit (HP:0000617)2.14717544
74Delusions (HP:0000746)2.13882711
75Hypoplasia of the brainstem (HP:0002365)2.09293551
76Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09293551
77Dysmetric saccades (HP:0000641)2.08992407
78Bradykinesia (HP:0002067)2.07931323
79Craniofacial dystonia (HP:0012179)2.06919460
80Absent speech (HP:0001344)2.06887530
81Akinesia (HP:0002304)2.06596716
82Clonus (HP:0002169)2.05362980
83Hemiplegia (HP:0002301)2.04659920
84Status epilepticus (HP:0002133)2.04499366
85Failure to thrive in infancy (HP:0001531)2.03605917
86Inability to walk (HP:0002540)2.03579660
87Fetal akinesia sequence (HP:0001989)2.02944234
88Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02904275
89Medial flaring of the eyebrow (HP:0010747)2.02565615
90Central scotoma (HP:0000603)2.01212974
91Diminished motivation (HP:0000745)2.01125795
92Renal cortical cysts (HP:0000803)2.00937825
93Prolonged QT interval (HP:0001657)1.99843136
94Gait imbalance (HP:0002141)1.98296190
95Syncope (HP:0001279)1.97942592
96Neuronal loss in central nervous system (HP:0002529)1.97695705
97Tetraplegia (HP:0002445)1.97534236
98Obstructive sleep apnea (HP:0002870)1.97090100
99Abnormal EKG (HP:0003115)1.96863762
100Muscular hypotonia of the trunk (HP:0008936)1.95692248
101Hypothermia (HP:0002045)1.94115543
102Atrophy/Degeneration involving motor neurons (HP:0007373)1.93925035
103Nephrogenic diabetes insipidus (HP:0009806)1.93542154
104Congenital primary aphakia (HP:0007707)1.92183946
105Specific learning disability (HP:0001328)1.90263876
106Bundle branch block (HP:0011710)1.89411593
107Abnormality of salivation (HP:0100755)1.89087279
108Insomnia (HP:0100785)1.89037720
109Abolished electroretinogram (ERG) (HP:0000550)1.88318072
110Impaired vibratory sensation (HP:0002495)1.88208553
111Abnormality of the labia minora (HP:0012880)1.86514918
112Gait ataxia (HP:0002066)1.83955599
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.83913310
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83913310
115Lissencephaly (HP:0001339)1.83796395
116Postural tremor (HP:0002174)1.81998636
117Rapidly progressive (HP:0003678)1.81967842
118Morphological abnormality of the pyramidal tract (HP:0002062)1.81450312
119Psychosis (HP:0000709)1.80681843
120Sleep apnea (HP:0010535)1.79744162
121CNS hypomyelination (HP:0003429)1.79405824
122Autoamputation (HP:0001218)1.77236625
123Pachygyria (HP:0001302)1.77186284
124Paraplegia (HP:0010550)1.75507252
125Abnormality of the heme biosynthetic pathway (HP:0010472)1.73736313
126Hypoplasia of the corpus callosum (HP:0002079)1.73536513
127Poor suck (HP:0002033)1.68695168
128Sudden death (HP:0001699)1.68616005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.87939295
2MAP3K93.75283922
3NTRK33.62703583
4MINK13.00628133
5MAP3K42.99591397
6EPHA42.75125763
7TXK2.65269201
8MAP2K72.55548629
9MAP4K22.40299421
10NTRK22.21153483
11PAK62.19910151
12FRK2.15536142
13DAPK22.13965942
14MAP3K122.03626465
15NTRK12.01351722
16CASK1.90994528
17KSR21.88174756
18MAPK131.87418708
19PHKG21.86721833
20PHKG11.86721833
21CAMKK11.74851639
22MAP2K41.74728936
23PRKD31.64969423
24CDK51.58779699
25EPHA31.58500669
26TAOK31.55744296
27KSR11.50262412
28TRIM281.49742596
29PLK21.49016484
30UHMK11.47619223
31CAMKK21.46225154
32DAPK11.36321805
33CDK191.30207638
34SIK21.29026898
35TNIK1.23018777
36GRK51.16593930
37LATS21.15587308
38SGK4941.13922650
39SGK2231.13922650
40PRPF4B1.11061060
41PRKCG1.08877423
42RIPK41.04960193
43FES1.04924258
44LMTK21.04438033
45CDK141.02306381
46DYRK21.02043038
47RET1.00652459
48MAP3K20.98911185
49CDK180.98735310
50CSNK1A1L0.98240813
51MARK20.95372749
52CDK150.94568074
53TAOK10.94462460
54ARAF0.90353305
55PAK30.90329869
56TYRO30.89801649
57CSNK1G10.89713584
58SYK0.89545330
59ITK0.88060016
60PRKCH0.87791191
61CSNK1G20.87279410
62CAMK2A0.86881802
63STK380.85479529
64SIK30.83668994
65FER0.83658799
66ADRBK20.81809531
67CDK11A0.81248609
68SGK20.79461163
69DYRK1A0.78638995
70LIMK10.77372298
71CAMK10.75208863
72ERBB30.74879781
73PNCK0.73145663
74SGK30.72995438
75DMPK0.72517321
76BCKDK0.71437717
77STK110.70446112
78TIE10.70355076
79TEC0.68579777
80RIPK10.67387964
81ALK0.63662033
82OXSR10.63635582
83CAMK2B0.60965091
84PRKCE0.60469559
85RPS6KA20.59907746
86CCNB10.58912200
87CAMK1G0.58412439
88FYN0.57695343
89PRKCZ0.57629251
90PRKG10.57516985
91WNK10.57374969
92SGK10.57238703
93GRK70.57220723
94MAP3K130.56057538
95TNK20.50173365
96CAMK2G0.50087755
97MAPK120.49874678
98MAPKAPK50.49555362
99CDC42BPA0.49249060
100MAP3K10.48841672
101PRKACA0.48351000
102PKN10.47575706
103SCYL20.47228110
104FGFR20.47054292
105PDK10.47035106
106WNK30.46114713
107CAMK2D0.46033854
108RAF10.45488774
109CAMK40.44395162
110TESK20.44257992
111PDPK10.43396175
112BCR0.42574665
113NEK10.42432295
114PTK2B0.42188071
115ROCK20.41489384
116PRKCA0.41136382
117RPS6KA30.40924785
118PRKCQ0.40749818
119PINK10.40672936
120PRKCB0.39732101
121CDK30.38770276
122OBSCN0.38742779
123MAPK100.38011004
124MAP3K50.37436595
125CSNK1D0.36599642
126BMPR20.36542303
127MAP3K60.35818006
128CSNK1G30.34922960
129PRKACG0.34743124
130CSNK1A10.34715495
131PRKD10.33142772
132ADRBK10.31955307

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.24487670
2Nicotine addiction_Homo sapiens_hsa050333.06841065
3Olfactory transduction_Homo sapiens_hsa047402.59802689
4Circadian entrainment_Homo sapiens_hsa047132.55247718
5GABAergic synapse_Homo sapiens_hsa047272.52693221
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46286702
7Long-term potentiation_Homo sapiens_hsa047202.37615227
8Glutamatergic synapse_Homo sapiens_hsa047242.35479255
9Morphine addiction_Homo sapiens_hsa050322.32384113
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22917279
11Dopaminergic synapse_Homo sapiens_hsa047282.19738685
12Amphetamine addiction_Homo sapiens_hsa050312.08423373
13Cholinergic synapse_Homo sapiens_hsa047251.98132472
14Insulin secretion_Homo sapiens_hsa049111.96665157
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88061671
16Salivary secretion_Homo sapiens_hsa049701.80813552
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80207829
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72133289
19Gastric acid secretion_Homo sapiens_hsa049711.67847997
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66479531
21Taste transduction_Homo sapiens_hsa047421.66011390
22Serotonergic synapse_Homo sapiens_hsa047261.65371324
23Long-term depression_Homo sapiens_hsa047301.62980231
24Cocaine addiction_Homo sapiens_hsa050301.59014838
25Renin secretion_Homo sapiens_hsa049241.56960917
26Oxytocin signaling pathway_Homo sapiens_hsa049211.51774520
27Gap junction_Homo sapiens_hsa045401.40426548
28Collecting duct acid secretion_Homo sapiens_hsa049661.36795052
29GnRH signaling pathway_Homo sapiens_hsa049121.34102408
30Type II diabetes mellitus_Homo sapiens_hsa049301.32431552
31Axon guidance_Homo sapiens_hsa043601.29782385
32Phototransduction_Homo sapiens_hsa047441.29307521
33Calcium signaling pathway_Homo sapiens_hsa040201.29272635
34Butanoate metabolism_Homo sapiens_hsa006501.28767807
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24486585
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24270642
37cAMP signaling pathway_Homo sapiens_hsa040241.19222908
38Regulation of autophagy_Homo sapiens_hsa041401.14237471
39Estrogen signaling pathway_Homo sapiens_hsa049151.14075732
40Glioma_Homo sapiens_hsa052141.11562269
41Vibrio cholerae infection_Homo sapiens_hsa051101.08719297
42ErbB signaling pathway_Homo sapiens_hsa040121.04521791
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03549418
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03136559
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97692311
46Cardiac muscle contraction_Homo sapiens_hsa042600.96512884
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.92934792
48Melanogenesis_Homo sapiens_hsa049160.90243538
49Oocyte meiosis_Homo sapiens_hsa041140.89624488
50Dilated cardiomyopathy_Homo sapiens_hsa054140.88805604
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.84142586
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.83457543
53Dorso-ventral axis formation_Homo sapiens_hsa043200.81091955
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81047330
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79765020
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78225866
57Pancreatic secretion_Homo sapiens_hsa049720.78113943
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77480302
59MAPK signaling pathway_Homo sapiens_hsa040100.76817219
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75821397
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75751980
62Parkinsons disease_Homo sapiens_hsa050120.74377720
63VEGF signaling pathway_Homo sapiens_hsa043700.74193421
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74113194
65Ether lipid metabolism_Homo sapiens_hsa005650.73689719
66Renal cell carcinoma_Homo sapiens_hsa052110.71882045
67Choline metabolism in cancer_Homo sapiens_hsa052310.71278315
68Endocytosis_Homo sapiens_hsa041440.70898113
69Endometrial cancer_Homo sapiens_hsa052130.70808858
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70178042
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.69139578
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67281308
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67178005
74Ras signaling pathway_Homo sapiens_hsa040140.66237363
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64891527
76mTOR signaling pathway_Homo sapiens_hsa041500.63702109
77Colorectal cancer_Homo sapiens_hsa052100.63110515
78Oxidative phosphorylation_Homo sapiens_hsa001900.62274719
79Thyroid hormone synthesis_Homo sapiens_hsa049180.62146974
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61725173
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60927181
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57950837
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56548601
84Rap1 signaling pathway_Homo sapiens_hsa040150.56397198
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56066265
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55007511
87Insulin signaling pathway_Homo sapiens_hsa049100.54438619
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53822569
89Circadian rhythm_Homo sapiens_hsa047100.53764572
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52215091
91Chemokine signaling pathway_Homo sapiens_hsa040620.51592654
92Glucagon signaling pathway_Homo sapiens_hsa049220.51536950
93Ovarian steroidogenesis_Homo sapiens_hsa049130.50616930
94Primary immunodeficiency_Homo sapiens_hsa053400.50389561
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50371748
96Alcoholism_Homo sapiens_hsa050340.50360006
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50124795
98Type I diabetes mellitus_Homo sapiens_hsa049400.50040600
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.48683937
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48651468
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47970586
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46975403
103Non-small cell lung cancer_Homo sapiens_hsa052230.46773216
104Linoleic acid metabolism_Homo sapiens_hsa005910.45629885
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44865717
106Inositol phosphate metabolism_Homo sapiens_hsa005620.44221908
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42666070
108Wnt signaling pathway_Homo sapiens_hsa043100.42358395
109Rheumatoid arthritis_Homo sapiens_hsa053230.41436205
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40284654
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40044075
112Alzheimers disease_Homo sapiens_hsa050100.37870811
113T cell receptor signaling pathway_Homo sapiens_hsa046600.37203953
114Prolactin signaling pathway_Homo sapiens_hsa049170.36868329
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35686814
116Prion diseases_Homo sapiens_hsa050200.35058838
117Platelet activation_Homo sapiens_hsa046110.34036990
118Nitrogen metabolism_Homo sapiens_hsa009100.33673286
119Peroxisome_Homo sapiens_hsa041460.28841846
120beta-Alanine metabolism_Homo sapiens_hsa004100.28671393
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23387704
122Fatty acid elongation_Homo sapiens_hsa000620.23163414
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22267035

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