MAPRE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.62810296
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.37493746
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.29005060
4synaptic vesicle exocytosis (GO:0016079)4.97278430
5locomotory exploration behavior (GO:0035641)4.84483704
6glutamate secretion (GO:0014047)4.77395627
7regulation of synaptic vesicle exocytosis (GO:2000300)4.59664159
8cerebellar granule cell differentiation (GO:0021707)4.57850283
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.56465716
10vocalization behavior (GO:0071625)4.34788616
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17867678
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.16150592
13regulation of synaptic vesicle transport (GO:1902803)4.10438349
14neuronal action potential propagation (GO:0019227)4.08314569
15protein localization to synapse (GO:0035418)4.05475868
16neurotransmitter secretion (GO:0007269)4.02087431
17regulation of glutamate receptor signaling pathway (GO:1900449)3.98886642
18postsynaptic membrane organization (GO:0001941)3.91271105
19cellular potassium ion homeostasis (GO:0030007)3.90954673
20exploration behavior (GO:0035640)3.82632064
21sodium ion export (GO:0071436)3.81704348
22L-amino acid import (GO:0043092)3.79346467
23regulation of neuronal synaptic plasticity (GO:0048168)3.78968814
24regulation of synapse structural plasticity (GO:0051823)3.74313342
25layer formation in cerebral cortex (GO:0021819)3.68441660
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.67336001
27positive regulation of dendritic spine development (GO:0060999)3.63844745
28amino acid import (GO:0043090)3.63301380
29neuromuscular process controlling posture (GO:0050884)3.56517998
30gamma-aminobutyric acid transport (GO:0015812)3.50465145
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49940637
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.48892812
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48207029
34cell communication by electrical coupling (GO:0010644)3.47091508
35regulation of synapse maturation (GO:0090128)3.46016276
36neuron cell-cell adhesion (GO:0007158)3.44933905
37activation of protein kinase A activity (GO:0034199)3.40097611
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35517082
39auditory behavior (GO:0031223)3.32254236
40synaptic transmission, glutamatergic (GO:0035249)3.31514914
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28009207
42dendritic spine organization (GO:0097061)3.27486946
43neurotransmitter transport (GO:0006836)3.26465570
44cytoskeletal anchoring at plasma membrane (GO:0007016)3.24380123
45neurotransmitter-gated ion channel clustering (GO:0072578)3.24170342
46positive regulation of neurotransmitter transport (GO:0051590)3.23400799
47regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.23339296
48response to pheromone (GO:0019236)3.22869784
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.21330623
50positive regulation of neurotransmitter secretion (GO:0001956)3.20481186
51dendritic spine morphogenesis (GO:0060997)3.19971569
52central nervous system myelination (GO:0022010)3.19317373
53axon ensheathment in central nervous system (GO:0032291)3.19317373
54long-term memory (GO:0007616)3.19256987
55proline transport (GO:0015824)3.19034755
56glycine transport (GO:0015816)3.17200614
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15220022
58cerebellar Purkinje cell differentiation (GO:0021702)3.14721404
59glutamate receptor signaling pathway (GO:0007215)3.14055922
60neuron-neuron synaptic transmission (GO:0007270)3.14015627
61membrane depolarization during action potential (GO:0086010)3.12175977
62positive regulation of membrane potential (GO:0045838)3.12113373
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09305025
64neuromuscular synaptic transmission (GO:0007274)3.07934830
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06273762
66regulation of vesicle fusion (GO:0031338)3.05106588
67regulation of cell communication by electrical coupling (GO:0010649)3.05016604
68synaptic vesicle endocytosis (GO:0048488)3.04193302
69regulation of dendritic spine development (GO:0060998)3.03963169
70regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01606120
71positive regulation of synapse maturation (GO:0090129)3.00808785
72regulation of neurotransmitter secretion (GO:0046928)3.00451668
73regulation of neurotransmitter levels (GO:0001505)2.99538564
74neuromuscular process controlling balance (GO:0050885)2.99419667
75regulation of synaptic plasticity (GO:0048167)2.98687405
76innervation (GO:0060384)2.98071074
77establishment of mitochondrion localization (GO:0051654)2.96600792
78negative regulation of dendrite morphogenesis (GO:0050774)2.94926375
79potassium ion homeostasis (GO:0055075)2.91823586
80regulation of postsynaptic membrane potential (GO:0060078)2.91637599
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91133838
82dendrite morphogenesis (GO:0048813)2.90646136
83potassium ion import (GO:0010107)2.89878713
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87460690
85neuron recognition (GO:0008038)2.84813281
86acidic amino acid transport (GO:0015800)2.84578765
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83316261
88long-term synaptic potentiation (GO:0060291)2.82902204
89synaptic vesicle transport (GO:0048489)2.80460886
90establishment of synaptic vesicle localization (GO:0097480)2.80460886
91vesicle transport along microtubule (GO:0047496)2.80087770
92regulation of ARF protein signal transduction (GO:0032012)2.80030767
93cellular sodium ion homeostasis (GO:0006883)2.79230490
94membrane hyperpolarization (GO:0060081)2.77281829
95mating behavior (GO:0007617)2.76473285
96regulation of neurotransmitter transport (GO:0051588)2.76289185
97transmission of nerve impulse (GO:0019226)2.75808175
98negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75663610
99regulation of dendritic spine morphogenesis (GO:0061001)2.75418841
100axonemal dynein complex assembly (GO:0070286)2.75070684
101neuronal ion channel clustering (GO:0045161)2.74988758
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.74383837
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.74380040
104cell differentiation in hindbrain (GO:0021533)2.74216643
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74174106
106chemosensory behavior (GO:0007635)2.73375025
107cerebellar Purkinje cell layer development (GO:0021680)2.72832574
108cell communication involved in cardiac conduction (GO:0086065)2.72111544
109membrane depolarization (GO:0051899)2.71253668
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.70949415
111response to auditory stimulus (GO:0010996)2.70670033
112detection of calcium ion (GO:0005513)2.70603737
113regulation of voltage-gated calcium channel activity (GO:1901385)2.70072895
114cell migration in hindbrain (GO:0021535)2.66996351
115calcium ion-dependent exocytosis (GO:0017156)2.66781286
116axonal fasciculation (GO:0007413)2.64596869
117membrane repolarization (GO:0086009)2.62516470
118organelle transport along microtubule (GO:0072384)2.61386430
119neuromuscular process (GO:0050905)2.60648687
120synaptic transmission (GO:0007268)2.60562100
121regulation of calcium ion-dependent exocytosis (GO:0017158)2.59860507
122axon cargo transport (GO:0008088)2.59524680
123prepulse inhibition (GO:0060134)2.59296502
124positive regulation of synaptic transmission (GO:0050806)2.56137298
125regulation of synaptic transmission (GO:0050804)2.55934519
126negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54749747
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54289946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.98603876
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83747330
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81322382
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62857034
5GBX2_23144817_ChIP-Seq_PC3_Human2.61798161
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.54834547
7DROSHA_22980978_ChIP-Seq_HELA_Human2.53821214
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52317084
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52238873
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52238873
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51198447
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46652932
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.41383523
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30846169
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30646629
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.30639565
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29548682
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26957822
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.26733099
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18807915
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.06839037
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.02913194
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96723391
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96577110
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90180445
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88825501
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86578258
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81022004
29AR_21572438_ChIP-Seq_LNCaP_Human1.62717263
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61255520
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59941750
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.58877421
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.45357988
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40192174
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39688516
36SMAD4_21799915_ChIP-Seq_A2780_Human1.36168320
37ZNF274_21170338_ChIP-Seq_K562_Hela1.34772038
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.29590779
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28331967
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27790599
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.27728359
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26945225
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26858471
44* SMC4_20622854_ChIP-Seq_HELA_Human1.26726541
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25599652
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25302326
47KDM2B_26808549_Chip-Seq_K562_Human1.24774356
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23528297
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23283491
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21636860
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20878344
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19331373
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19160143
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.18726281
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18038625
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17945317
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17265023
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15641395
59AR_19668381_ChIP-Seq_PC3_Human1.15576140
60* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15428318
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14205313
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10957815
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10546287
64CTCF_27219007_Chip-Seq_Bcells_Human1.10196177
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08683202
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07365764
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06744500
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05866410
69CREB1_26743006_Chip-Seq_LNCaP_Human1.03929297
70AR_25329375_ChIP-Seq_VCAP_Human1.02947609
71STAT3_23295773_ChIP-Seq_U87_Human1.01006199
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.00991366
73TAF15_26573619_Chip-Seq_HEK293_Human1.00931681
74P68_20966046_ChIP-Seq_HELA_Human1.00905147
75RING1B_27294783_Chip-Seq_NPCs_Mouse0.99969785
76* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99830666
77* OCT4_19829295_ChIP-Seq_ESCs_Human0.99303803
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99133109
79SMAD3_21741376_ChIP-Seq_EPCs_Human0.98634396
80* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97729132
81ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97708660
82SMAD4_21741376_ChIP-Seq_HESCs_Human0.96548371
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95838309
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.95052238
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94311121
86* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94175710
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93959248
88GATA1_26923725_Chip-Seq_HPCs_Mouse0.93387820
89P300_19829295_ChIP-Seq_ESCs_Human0.93246656
90AHR_22903824_ChIP-Seq_MCF-7_Human0.93081829
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92905486
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92895354
93* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92765683
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92686766
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91780789
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.90246814
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90081441
98KDM2B_26808549_Chip-Seq_DND41_Human0.89941118
99* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89185073
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.89108724
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88199467
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88184628
103* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87169512
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86889803
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86738585
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86542957
107* TP53_20018659_ChIP-ChIP_R1E_Mouse0.85032616
108* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85023513
109* TP53_23651856_ChIP-Seq_MEFs_Mouse0.84685397
110TCF4_23295773_ChIP-Seq_U87_Human0.84552302
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84536024
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.84378925
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83020242
114DPY_21335234_ChIP-Seq_ESCs_Mouse0.82353707
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82161055
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81903868
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81869838
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81805931
119* KLF4_19829295_ChIP-Seq_ESCs_Human0.81622598
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80786335
121RNF2_27304074_Chip-Seq_NSC_Mouse0.79661110
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79074063
123LXR_22292898_ChIP-Seq_THP-1_Human0.79036278
124SA1_27219007_Chip-Seq_ERYTHROID_Human0.78364365
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78059245
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77491751
127IGF1R_20145208_ChIP-Seq_DFB_Human0.77044369
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.77016822
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76962850
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76682944
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76560877
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76538801
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.75558938
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.74855492
135EGR1_19032775_ChIP-ChIP_M12_Human0.73796688
136SA1_27219007_Chip-Seq_Bcells_Human0.73680953
137* SMAD4_21741376_ChIP-Seq_ESCs_Human0.72149504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77348643
2MP0003880_abnormal_central_pattern3.89325490
3MP0004270_analgesia3.74500786
4MP0003635_abnormal_synaptic_transmissio3.66794966
5MP0009745_abnormal_behavioral_response2.87795068
6MP0002063_abnormal_learning/memory/cond2.86031449
7MP0002064_seizures2.81159848
8MP0001968_abnormal_touch/_nociception2.78075898
9MP0009046_muscle_twitch2.74825244
10MP0005423_abnormal_somatic_nervous2.68028107
11MP0002734_abnormal_mechanical_nocicepti2.53867936
12MP0002272_abnormal_nervous_system2.41440391
13MP0002572_abnormal_emotion/affect_behav2.37763647
14MP0002822_catalepsy2.28603680
15MP0001486_abnormal_startle_reflex2.27232944
16MP0002909_abnormal_adrenal_gland2.15644284
17MP0002735_abnormal_chemical_nociception2.11533855
18MP0002736_abnormal_nociception_after2.08335334
19MP0003329_amyloid_beta_deposits2.04336114
20MP0009780_abnormal_chondrocyte_physiolo2.03825574
21MP0002733_abnormal_thermal_nociception2.00037910
22MP0004858_abnormal_nervous_system1.94633868
23MP0001970_abnormal_pain_threshold1.86590171
24MP0001501_abnormal_sleep_pattern1.80040110
25MP0008569_lethality_at_weaning1.79541809
26MP0001440_abnormal_grooming_behavior1.79288808
27MP0001984_abnormal_olfaction1.78582401
28MP0002067_abnormal_sensory_capabilities1.78320950
29MP0002837_dystrophic_cardiac_calcinosis1.71454785
30MP0005551_abnormal_eye_electrophysiolog1.71220889
31MP0002184_abnormal_innervation1.70567211
32MP0005646_abnormal_pituitary_gland1.67699537
33MP0000751_myopathy1.67152658
34MP0006276_abnormal_autonomic_nervous1.66534964
35MP0004811_abnormal_neuron_physiology1.64239268
36MP0004145_abnormal_muscle_electrophysio1.53545186
37MP0000955_abnormal_spinal_cord1.53141147
38MP0002557_abnormal_social/conspecific_i1.52817170
39MP0000013_abnormal_adipose_tissue1.51833686
40MP0004924_abnormal_behavior1.50795493
41MP0005386_behavior/neurological_phenoty1.50795493
42MP0001502_abnormal_circadian_rhythm1.48604851
43MP0005645_abnormal_hypothalamus_physiol1.44802417
44MP0004885_abnormal_endolymph1.42857535
45MP0000778_abnormal_nervous_system1.41918857
46MP0002882_abnormal_neuron_morphology1.41747719
47MP0003879_abnormal_hair_cell1.33363392
48MP0002066_abnormal_motor_capabilities/c1.32722588
49MP0003633_abnormal_nervous_system1.31451437
50MP0008961_abnormal_basal_metabolism1.26576422
51MP0004142_abnormal_muscle_tone1.22619307
52MP0002229_neurodegeneration1.22590902
53MP0003122_maternal_imprinting1.20136698
54MP0002090_abnormal_vision1.14099243
55MP0004233_abnormal_muscle_weight1.10274054
56MP0003283_abnormal_digestive_organ1.09510888
57MP0006072_abnormal_retinal_apoptosis1.09092653
58MP0003631_nervous_system_phenotype1.07495883
59MP0003123_paternal_imprinting1.06423496
60MP0004043_abnormal_pH_regulation1.05488238
61MP0003634_abnormal_glial_cell1.02972900
62MP0001529_abnormal_vocalization0.99118291
63MP0002069_abnormal_eating/drinking_beha0.98459155
64MP0005535_abnormal_body_temperature0.97888266
65MP0004215_abnormal_myocardial_fiber0.96857123
66MP0004085_abnormal_heartbeat0.95397737
67MP0010386_abnormal_urinary_bladder0.94511738
68MP0002152_abnormal_brain_morphology0.94200151
69MP0000604_amyloidosis0.94131064
70MP0001905_abnormal_dopamine_level0.92254110
71MP0000747_muscle_weakness0.90198599
72MP0000920_abnormal_myelination0.88485763
73MP0005253_abnormal_eye_physiology0.88121660
74MP0003137_abnormal_impulse_conducting0.87022727
75MP0003690_abnormal_glial_cell0.86471630
76MP0004036_abnormal_muscle_relaxation0.84607882
77MP0002752_abnormal_somatic_nervous0.84060285
78MP0003075_altered_response_to0.83460602
79MP0004130_abnormal_muscle_cell0.83446750
80MP0002638_abnormal_pupillary_reflex0.83296643
81MP0003646_muscle_fatigue0.81743159
82MP0004147_increased_porphyrin_level0.81641115
83MP0002249_abnormal_larynx_morphology0.80321759
84MP0008874_decreased_physiological_sensi0.79666921
85MP0001348_abnormal_lacrimal_gland0.79649372
86MP0003787_abnormal_imprinting0.79377853
87MP0005167_abnormal_blood-brain_barrier0.79115683
88MP0003183_abnormal_peptide_metabolism0.78372836
89MP0003632_abnormal_nervous_system0.75387987
90MP0001346_abnormal_lacrimal_gland0.75119406
91MP0000749_muscle_degeneration0.74979140
92MP0008872_abnormal_physiological_respon0.74624213
93MP0001299_abnormal_eye_distance/0.71497229
94MP0005623_abnormal_meninges_morphology0.70103118
95MP0002653_abnormal_ependyma_morphology0.69867771
96MP0004510_myositis0.69436633
97MP0005410_abnormal_fertilization0.67798254
98MP0004742_abnormal_vestibular_system0.67726350
99MP0000631_abnormal_neuroendocrine_gland0.67482871
100MP0001188_hyperpigmentation0.67158582
101MP0001963_abnormal_hearing_physiology0.65835030
102MP0002234_abnormal_pharynx_morphology0.65498870
103MP0000003_abnormal_adipose_tissue0.65304686
104MP0002269_muscular_atrophy0.63592628
105MP0000759_abnormal_skeletal_muscle0.63510788
106MP0005409_darkened_coat_color0.62989958
107MP0003172_abnormal_lysosome_physiology0.62507193
108MP0005620_abnormal_muscle_contractility0.62186088
109MP0000579_abnormal_nail_morphology0.61656525
110MP0001177_atelectasis0.61403712
111MP0002078_abnormal_glucose_homeostasis0.60829321
112MP0000566_synostosis0.60686791
113MP0001943_abnormal_respiration0.56854826
114MP0005394_taste/olfaction_phenotype0.56369602
115MP0005499_abnormal_olfactory_system0.56369602
116MP0004087_abnormal_muscle_fiber0.56357353
117MP0010769_abnormal_survival0.52588769
118MP0002332_abnormal_exercise_endurance0.51967335
119MP0001485_abnormal_pinna_reflex0.50524983

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.24088129
2Focal motor seizures (HP:0011153)5.65816843
3Visual hallucinations (HP:0002367)4.74257426
4Focal seizures (HP:0007359)4.61843648
5Action tremor (HP:0002345)4.01180222
6Epileptic encephalopathy (HP:0200134)3.88664234
7Progressive cerebellar ataxia (HP:0002073)3.77819305
8Supranuclear gaze palsy (HP:0000605)3.74217505
9Diplopia (HP:0000651)3.71448116
10Abnormality of binocular vision (HP:0011514)3.71448116
11Atonic seizures (HP:0010819)3.68474134
12Obstructive sleep apnea (HP:0002870)3.55047811
13Ankle clonus (HP:0011448)3.48407688
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.45307037
15Absence seizures (HP:0002121)3.45088574
16Febrile seizures (HP:0002373)3.40465444
17Generalized tonic-clonic seizures (HP:0002069)3.30761873
18Depression (HP:0000716)3.15997509
19Dialeptic seizures (HP:0011146)3.10088650
20Abnormal respiratory motile cilium morphology (HP:0005938)3.04343106
21Abnormal respiratory epithelium morphology (HP:0012253)3.04343106
22Akinesia (HP:0002304)2.95535061
23Abnormal respiratory motile cilium physiology (HP:0012261)2.90531543
24Dynein arm defect of respiratory motile cilia (HP:0012255)2.89769616
25Absent/shortened dynein arms (HP:0200106)2.89769616
26Anxiety (HP:0000739)2.88855556
27Postural instability (HP:0002172)2.85490602
28Central scotoma (HP:0000603)2.84803556
29Abnormal ciliary motility (HP:0012262)2.81547376
30Dysdiadochokinesis (HP:0002075)2.81545179
31Tetraplegia (HP:0002445)2.80294212
32Neurofibrillary tangles (HP:0002185)2.79541081
33Ventricular fibrillation (HP:0001663)2.78365518
34Annular pancreas (HP:0001734)2.76723201
35Pheochromocytoma (HP:0002666)2.74575503
36Torticollis (HP:0000473)2.73599909
37Abnormality of the lower motor neuron (HP:0002366)2.72348991
38Abnormal eating behavior (HP:0100738)2.71672093
39Dysmetria (HP:0001310)2.70733540
40Sleep apnea (HP:0010535)2.66447108
41Impaired vibration sensation in the lower limbs (HP:0002166)2.66388025
42Truncal ataxia (HP:0002078)2.63078522
43Poor eye contact (HP:0000817)2.61950912
44Rhinitis (HP:0012384)2.58018427
45Impaired social interactions (HP:0000735)2.56801659
46Abnormal social behavior (HP:0012433)2.56801659
47Cerebral hypomyelination (HP:0006808)2.56564498
48Urinary bladder sphincter dysfunction (HP:0002839)2.55654644
49Hand muscle atrophy (HP:0009130)2.52791688
50Exercise-induced myalgia (HP:0003738)2.51530183
51Cerebral inclusion bodies (HP:0100314)2.50641051
52Focal dystonia (HP:0004373)2.49455108
53Spastic gait (HP:0002064)2.48177091
54Mutism (HP:0002300)2.46752666
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45826431
56Upper limb amyotrophy (HP:0009129)2.44429922
57Distal upper limb amyotrophy (HP:0007149)2.44429922
58Broad-based gait (HP:0002136)2.42777179
59Peripheral hypomyelination (HP:0007182)2.42412961
60Hemiparesis (HP:0001269)2.40744862
61Gaze-evoked nystagmus (HP:0000640)2.40508680
62Genetic anticipation (HP:0003743)2.39723045
63Bundle branch block (HP:0011710)2.39386128
64Urinary urgency (HP:0000012)2.38622173
65Intention tremor (HP:0002080)2.37111304
66Congenital stationary night blindness (HP:0007642)2.36791292
67EEG with generalized epileptiform discharges (HP:0011198)2.34893160
68Epileptiform EEG discharges (HP:0011182)2.34408985
69Neuroendocrine neoplasm (HP:0100634)2.34204068
70Craniofacial dystonia (HP:0012179)2.29824486
71Scanning speech (HP:0002168)2.29738663
72Agitation (HP:0000713)2.29658619
73Apathy (HP:0000741)2.28862592
74Megalencephaly (HP:0001355)2.27990146
75Lower limb amyotrophy (HP:0007210)2.27920612
76Hypsarrhythmia (HP:0002521)2.25760979
77Hyperventilation (HP:0002883)2.22376471
78Amblyopia (HP:0000646)2.20832617
79Bradykinesia (HP:0002067)2.17049006
80Status epilepticus (HP:0002133)2.15053687
81Hemiplegia (HP:0002301)2.13494543
82Termporal pattern (HP:0011008)2.11936141
83Insidious onset (HP:0003587)2.11936141
84Foot dorsiflexor weakness (HP:0009027)2.08138748
85Lower limb muscle weakness (HP:0007340)2.07531683
86Papilledema (HP:0001085)2.07524815
87Diminished motivation (HP:0000745)2.07188727
88Prolonged QT interval (HP:0001657)2.06448569
89Muscle fiber splitting (HP:0003555)2.06223951
90Abnormality of macular pigmentation (HP:0008002)2.06036432
91Clonus (HP:0002169)2.02886030
92Hyporeflexia of lower limbs (HP:0002600)2.01150478
93Abnormal EKG (HP:0003115)2.00563128
94Drooling (HP:0002307)1.99479574
95Excessive salivation (HP:0003781)1.99479574
96Heart block (HP:0012722)1.98730405
97Abnormality of the foot musculature (HP:0001436)1.98339020
98Rapidly progressive (HP:0003678)1.95283581
99Polyphagia (HP:0002591)1.95282855
100Impaired smooth pursuit (HP:0007772)1.94374656
101Fetal akinesia sequence (HP:0001989)1.93636526
102Limb dystonia (HP:0002451)1.93395162
103Hypercortisolism (HP:0001578)1.93347581
104Insomnia (HP:0100785)1.92574315
105Dysmetric saccades (HP:0000641)1.92211737
106Scotoma (HP:0000575)1.91788094
107Spastic tetraparesis (HP:0001285)1.91631969
108Rigidity (HP:0002063)1.89706689
109Neoplasm of the heart (HP:0100544)1.89187306
110Abnormal atrioventricular conduction (HP:0005150)1.88358504
111Progressive inability to walk (HP:0002505)1.87577499
112Failure to thrive in infancy (HP:0001531)1.85533784
113Hypoventilation (HP:0002791)1.83780213
114Generalized myoclonic seizures (HP:0002123)1.81541849
115Sudden death (HP:0001699)1.81477516
116Atelectasis (HP:0100750)1.81099314
117Postural tremor (HP:0002174)1.80160525
118Abnormality of the corticospinal tract (HP:0002492)1.79744900
119Impaired vibratory sensation (HP:0002495)1.79079289
120Exercise-induced muscle cramps (HP:0003710)1.79045580
121Syncope (HP:0001279)1.78738027
122Slow progression (HP:0003677)1.78327905
123Myotonia (HP:0002486)1.77804076
124Psychosis (HP:0000709)1.77000335
125Delusions (HP:0000746)1.76593386
126Incomplete penetrance (HP:0003829)1.76219679
127Hammertoe (HP:0001765)1.74192877
128Neuronal loss in central nervous system (HP:0002529)1.73843494
129Abnormality of ocular smooth pursuit (HP:0000617)1.73547161
130Stereotypic behavior (HP:0000733)1.73107249
131Gait ataxia (HP:0002066)1.72127614
132Neoplasm of the peripheral nervous system (HP:0100007)1.69351813
133Anosmia (HP:0000458)1.66507378
134Absent speech (HP:0001344)1.66145690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.92448147
2MAP3K93.57369708
3EPHA43.35867804
4PRKD32.64463777
5PAK62.59166529
6MINK12.57911581
7MAP3K42.52757804
8MARK12.52621349
9KSR22.34121881
10DAPK22.27491991
11NTRK11.95283485
12MAP2K41.86375456
13MAP2K71.82619601
14PHKG21.82303261
15PHKG11.82303261
16NTRK21.76613098
17CAMKK11.75483353
18ARAF1.65366575
19STK381.52794977
20CDK51.46692701
21KSR11.41967822
22UHMK11.38678387
23PINK11.34291455
24MAP3K121.34176664
25LMTK21.33680782
26MAP3K21.31060274
27GRK51.29884989
28TESK11.25522709
29PRPF4B1.22703901
30PAK31.21294986
31MAPK121.13403783
32PRKCG1.13236166
33TAOK11.11593660
34WNK31.07023029
35SGK2231.06922175
36SGK4941.06922175
37PRKCH1.04478185
38TYRO31.04133029
39CDK191.03412721
40MAP3K131.03201519
41CAMKK21.02753915
42RET1.00371204
43DAPK11.00117184
44MAP3K10.98170790
45LATS20.97865464
46RIPK10.96652049
47RIPK40.94402176
48NEK60.92394227
49MAPK130.91585058
50CAMK2A0.88581449
51CDK140.87828109
52CDK180.86959863
53WNK40.85700838
54CDK150.85689666
55FER0.85052692
56CAMK10.84772128
57TNIK0.83875575
58SIK20.83699412
59CASK0.83625818
60PLK20.83329088
61WNK10.81215351
62FES0.80511888
63INSRR0.78869722
64PNCK0.78588716
65NEK10.78522826
66PKN10.78250417
67MAP3K110.77154252
68OBSCN0.74557586
69STK110.74405523
70CDK11A0.74288392
71PDPK10.73592356
72PTK2B0.73422214
73MARK20.71930729
74ICK0.71671443
75SGK30.69445367
76CAMK2B0.69189467
77OXSR10.67456327
78MAPK150.66824179
79CAMK1G0.65908592
80PDK10.65554960
81DYRK1A0.65302575
82SGK20.64646637
83CAMK2D0.63752528
84CAMK2G0.62356796
85CDC42BPA0.61826704
86MAP3K70.61154717
87PRKCZ0.58625714
88DAPK30.58338416
89ROCK20.58316978
90MAP2K10.57196815
91RAF10.56665969
92TRIB30.56477529
93SGK10.56282431
94TNK20.53604872
95PRKCE0.51122336
96DMPK0.50523827
97RPS6KA30.49348858
98CSNK1G20.48987979
99ROCK10.48150369
100ALK0.47055356
101PDK30.44970516
102PDK40.44970516
103EEF2K0.44888089
104BRSK10.43627779
105MAPK100.43057896
106NME10.42695677
107RPS6KA20.42138584
108CAMK40.41634511
109DYRK1B0.41490512
110STK390.40771917
111BRAF0.40161496
112BMPR20.39749972
113LIMK10.39130496
114FYN0.38558709
115MOS0.37788695
116PRKAA10.35567271
117MAP2K60.34744659
118TAOK20.33341234
119ERBB20.31656033
120CCNB10.31594560
121PRKD10.31263526

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.22921671
2Nicotine addiction_Homo sapiens_hsa050332.87529750
3GABAergic synapse_Homo sapiens_hsa047272.57578085
4Olfactory transduction_Homo sapiens_hsa047402.43573022
5Circadian entrainment_Homo sapiens_hsa047132.40246980
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37037607
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25828362
8Insulin secretion_Homo sapiens_hsa049112.24307962
9Glutamatergic synapse_Homo sapiens_hsa047242.15184288
10Morphine addiction_Homo sapiens_hsa050322.13437538
11Long-term potentiation_Homo sapiens_hsa047202.07197728
12Amphetamine addiction_Homo sapiens_hsa050312.00386382
13Nitrogen metabolism_Homo sapiens_hsa009101.96986218
14Dopaminergic synapse_Homo sapiens_hsa047281.89411767
15Salivary secretion_Homo sapiens_hsa049701.80882778
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77976773
17Cholinergic synapse_Homo sapiens_hsa047251.72803222
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68533961
19Gastric acid secretion_Homo sapiens_hsa049711.67283140
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62842826
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61552877
22Phototransduction_Homo sapiens_hsa047441.61459855
23Taste transduction_Homo sapiens_hsa047421.50552123
24Cocaine addiction_Homo sapiens_hsa050301.49640009
25Oxytocin signaling pathway_Homo sapiens_hsa049211.45904766
26Renin secretion_Homo sapiens_hsa049241.42919585
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39853114
28Serotonergic synapse_Homo sapiens_hsa047261.35880768
29Collecting duct acid secretion_Homo sapiens_hsa049661.29947938
30Long-term depression_Homo sapiens_hsa047301.28963598
31Calcium signaling pathway_Homo sapiens_hsa040201.27541818
32GnRH signaling pathway_Homo sapiens_hsa049121.26150083
33Type II diabetes mellitus_Homo sapiens_hsa049301.25870600
34Cardiac muscle contraction_Homo sapiens_hsa042601.20990298
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18450150
36Gap junction_Homo sapiens_hsa045401.12384322
37cAMP signaling pathway_Homo sapiens_hsa040241.10423067
38Vitamin B6 metabolism_Homo sapiens_hsa007501.06941416
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05263872
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02162827
41Estrogen signaling pathway_Homo sapiens_hsa049150.99326797
42Vibrio cholerae infection_Homo sapiens_hsa051100.96723691
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95835024
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92490251
45Bile secretion_Homo sapiens_hsa049760.91908956
46Dilated cardiomyopathy_Homo sapiens_hsa054140.91494540
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88239553
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.87850665
49Glioma_Homo sapiens_hsa052140.85932714
50Axon guidance_Homo sapiens_hsa043600.85295148
51Melanogenesis_Homo sapiens_hsa049160.84423625
52Glucagon signaling pathway_Homo sapiens_hsa049220.83370951
53Pancreatic secretion_Homo sapiens_hsa049720.82616162
54ErbB signaling pathway_Homo sapiens_hsa040120.81992483
55Dorso-ventral axis formation_Homo sapiens_hsa043200.81882125
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80814117
57Thyroid hormone synthesis_Homo sapiens_hsa049180.79227611
58Phenylalanine metabolism_Homo sapiens_hsa003600.78047803
59Arginine biosynthesis_Homo sapiens_hsa002200.76478271
60Butanoate metabolism_Homo sapiens_hsa006500.71779989
61Circadian rhythm_Homo sapiens_hsa047100.71185455
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71015515
63Histidine metabolism_Homo sapiens_hsa003400.69451722
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.69390487
65Arginine and proline metabolism_Homo sapiens_hsa003300.68226269
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66261838
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63233824
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62823764
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61371905
70Prion diseases_Homo sapiens_hsa050200.60469881
71Insulin signaling pathway_Homo sapiens_hsa049100.58219226
72Choline metabolism in cancer_Homo sapiens_hsa052310.56594284
73AMPK signaling pathway_Homo sapiens_hsa041520.56297157
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56225792
75beta-Alanine metabolism_Homo sapiens_hsa004100.55846534
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54524111
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54085749
78MAPK signaling pathway_Homo sapiens_hsa040100.52231794
79VEGF signaling pathway_Homo sapiens_hsa043700.51984672
80Tight junction_Homo sapiens_hsa045300.51332759
81Oocyte meiosis_Homo sapiens_hsa041140.50937259
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50873823
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50429036
84Endocytosis_Homo sapiens_hsa041440.49839360
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.49534202
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48140188
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47913732
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.46942111
89mTOR signaling pathway_Homo sapiens_hsa041500.43995192
90Ras signaling pathway_Homo sapiens_hsa040140.43307145
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42526789
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.40998774
93Renal cell carcinoma_Homo sapiens_hsa052110.38209007
94Fatty acid biosynthesis_Homo sapiens_hsa000610.37900093
95Inositol phosphate metabolism_Homo sapiens_hsa005620.37440642
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36273865
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36262336
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36022477
99Ovarian steroidogenesis_Homo sapiens_hsa049130.35079148
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.34692294
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34340975
102Rap1 signaling pathway_Homo sapiens_hsa040150.32858998
103Endometrial cancer_Homo sapiens_hsa052130.32219567
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.29057367
105Type I diabetes mellitus_Homo sapiens_hsa049400.28810327
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28381408
107Alzheimers disease_Homo sapiens_hsa050100.28096919
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.27879109
109Alcoholism_Homo sapiens_hsa050340.27067588
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26748847
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24749569
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24724521

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